180 results about "Growth retardant" patented technology

The present invention discloses compositions and methods for enhancing the effect (e.g., duration) of a neurotoxin treatment. The compositions herein include neurotoxins and neuron growth inhibitors. Such compositions are administered locally to treat or prevent conditions, such as dermatological conditions, urological conditions, thyroid conditions, optical conditions, and neurological conditions.

A medical device for drug delivery is provided which includes a stent structure and a biologically active structure attached to the stent structure. The biologically active structure is comprised of a plurality of layers, including a first layer having a first biologically active compound, such as an anti-proliferative, cytostatic or cytotoxic drug, for delivery at a first target site, such as the vascular tissue; a second layer having a second biologically active compound, such as a growth factor, for delivery into the arterial lumen and capable of promoting engraftment and differentiation of hematopoietic stem cells and / or endothelial progenitor cells at a second site of myocardial injury; and a third, middle layer which is substantially or selectively impermeable to both the first and second biologically active compounds.

The invention provides a super hard and tough, nano-crystal austenite steel bulk material having an improved corrosion resistance, and its preparation process. The austenite steel bulk material comprises an aggregate of austenite nano-crystal grains containing 0.1 to 2.0% (by mass) of a solid solution type nitrogen, wherein an oxide, nitride, carbide or the like of a metal or semimetal exists as a crystal grain growth inhibitor between and / or in said nano-crystal grains. For preparation, fine powders of austenite steel-forming components, i.e., iron and chromium, nickel, manganese, carbon or the like are mixed with a substance that becomes a nitrogen source. Mechanical alloying (MA) is applied to the mixture, thereby preparing nano-crystal austenite steel powders having a high nitrogen concentration. Finally, the austenite steel powders are consolidated by sintering by means of spark plasma sintering, rolling or the like.

The present invention provides a mesothelioma therapeutic agent containing an interleukin-6 (IL-6) antagonist such as antibody to IL-6 receptor (IL-6R), and a mesothelioma cell growth inhibitor containing an IL-6 antagonist such as antibody to IL-6R.

The present invention features methods and formulations or compositions for the treatment of colon cancer, and particularly for the inhibition, prevention and / or reduction of cancerous cell growth, as well as the destruction of early stage cancerous cells within the colon region of a mammal, wherein the formulations and compositions comprise an identified amount or concentration of a processed Morinda citrifolia product or an active ingredient there from, as obtained from the Indian Mulberry plant.

Disclosed is a method for recovering and re-employing ionic surfactants from solutions, dispersions and emulsions of water and liquid hydrocarbons, by the addition of a second non-aqueous polar phase and an inorganic salt which changes the ionic strength of the surfactant and causes the surfactant to partition principally into the non-aqueous second polar phase. More specifically, the method applies to recovering hydrate growth inhibitor / modifying compounds, with cationic surfactants such as ammonium, phosphonium and sulphonium alkylated compounds from the effluent of hydrocarbon production wells; the effluent including water, hydrate inhibitor compound, at least one additional polar solvent and inorganic salt. Sufficient additional ions of inorganic salt, and if necessary, an alcohol / glycol are added to the effluent to form a second polar phase that is less polar than the aqueous phase, into which the hydrate inhibitor can then dissolve and be separated from the effluent.

The present invention provides a method of producing a solid oxide fuel cell, comprising the steps of: forming an anode support layer; applying an anode layer on the anode support layer; applying an electrolyte layer on the anode layer; and sintering the obtained structure; wherein the anode support layer and / or the anode layer comprises a composition comprising doped zirconia, doped ceria and / or a metal oxide with an oxygen ion or proton conductivity, NiO and at least one oxide selected from the group consisting of AI2O3, TiO2, Cr2O3, Sc2O3, VOx, TaOx, MnOx, NbOx, CaO, Bi2O3, LnOx, MgCr2O4, MgTiO3, CaAI2O4, LaAIO3, YbCrO3, ErCrO4, NiTiO3, NiCr2O4, and mixtures thereof. According to the invention, a combination of nickel coarsening prevention due to specific Ni-particle growth inhibitors, and, at the same time, a strengthening of the ceramic structure of the anode support layer and / or the anode layer is achieved.

A method comprising incorporation of an inorganic polymer precursor of a grain growth inhibitor into nanostructured materials or intermediates useful for the production of nanostructured materials. The precursor / nanostructured material composite is optionally heat treated at a temperature below the grain growth temperature of the nanostructured material in order to more effectively disperse the precursor. The composites are then heat treated at a temperature effective to decompose the precursor and to form nanostructured materials having grain growth inhibitors uniformly distributed at the grain boundaries. Synthesis of the inorganic polymer solution comprises forming an inorganic polymer from a solution of metal salts, filtering the polymer, and drying. Alloying additives as well as grain growth inhibitors may be incorporated into the nanostructured materials.

The invention discloses a multifunctional seedling cultivation substrate which comprises the components of EM fermented maize straws, perlite, vermiculite and prohexadione calcium, wherein the volume ratio of the EM fermented maize straws, the perlite and the vermiculite is 6: 3: 1, and the amount of the prohexadione calcium is 10-20g / m<3>. The multifunctional seedling cultivation substrate can control excessive growth of seedlings and can effectively prevent side effects of sprayed conventional growth inhibitors, and cultivated seedlings are superior to existing conventional seedling cultivation substrates in root activity, strong seedling index, yield and other aspects. Meanwhile, using amount of grass carbon is reduced, grass carbon resource saving is facilitated, and the purposes of resource utilization of agricultural wastes and environment pollution reduction are achieved.

Methods and compositions are provided which contains preparations of calcium chelators, bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective against calcium phosphate-crystal nucleation and crystal growth, and / or a combination of supportive agents and which may be used for treating and or reducing pathological calcifications, the growth of Nanobacterium and calcification-induced diseases including, but not limited to, Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke, Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome, Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma, Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma), Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus), Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications in vivo.

The invention relates to a nonmagnetic hard alloy material and a preparation method thereof. The alloy comprises (wt %) tungsten carbide 75-90, nickel powder 8-20, chromium carbide 0.5-3.0, and vanadium carbide 0.3-2.5. The preparation method comprises compounding, wet grinding, drying, pressing, sintering and checking, wherein in the wet grinding step, a nonmagnetic alloy lining board wet grinder is used, alcohol or acetone is added as grinding medium, nonmagnetic hard alloy balls is used as grinding material, the ratio of grinding medium to material is 5:1, the solid-to-liquid ratio is 350ml / Kg, and the wet grinding time is 48-56 hours; and pressure sintering is adopted. In the inventive nonmagnetic hard alloy material, fine-particle tungsten carbide powder (1.0-1.5 mum) is used as hard phase, so as to improve the hardness and abrasion resistance of the alloy. The nickel is used as binder, and a small amount of chromium carbide and vanadium carbide are added as tungsten carbide grain growth inhibitor, so as to refine tungsten carbide crystal grains, and further improve the hardness and abrasion resistance of the alloy. The pressure sintering technique accelerates densification speed during sintering process, effectively reduces porosity of the alloy, and remarkably improves the strength of the alloy.

The invention provides an agent for preventing or treating arthritis, a cartilage protecting agent, a joint destruction inhibitor and a synovial membrane growth inhibitor comprising an anti-FGF-8 neutralizing antibody as an active ingredient, as well as a diagnostic agent of arthritis comprising an anti-FGF-8 antibody as an active ingredient and a method for judging arthritis using the antibody.

The invention belongs to the field of plant tissue cultivation, and particularly relates to a method of cutting propagation of a peony immature stem. The method includes the steps of material selection, cutting cultivation, indoor management, oversummer maintenance, overwinter management and strong seedling cultivation. By using low-frequency ultrasonic waves to conduct processing, rooting can be promoted, plant cell division can be remarkably accelerated and induced, the cell growth is stimulated, protein synthesis of protoplast can be accelerated, and the adventitious bud reproducibility can be improved. Due to the fact that intermittent irradiation is adopted, no drastic cavitation effect can be produced, and partial damage to cells caused by the ultrasonic waves can be avoided. Due to the fact that cultivation and rooting are conducted in the dark cultivation process, growth inhibitor is greatly reduced, and rooting is facilitated. The complete and specific method including the steps of oversummer maintenance, auxiliary bud inducing, overwinter management and strong seedling cultication is provided, and therefore application of the peony rapid cutting propagation technology in actual production is promoted, and the method has significance in large-scale production of peony seedlings.

Disclosed herein are a method for preparing zinc oxide (ZnO) nanoparticles and a method for preparing ZnO nanorods. The method for preparing ZnO nanoparticles may include: preparing a growth solution containing a zinc salt, a precipitator, and a growth inhibitor; and applying heat to the growth solution to prepare ZnO nanoparticles. Moreover, the method for preparing ZnO nanorods may include: forming a ZnO seed layer on a substrate; forming a pattern layer including a plurality of holes on the ZnO seed layer; preparing a growth solution containing a zinc salt, a precipitator, and a growth inhibitor; and immersing the substrate including the pattern layer in the growth solution such that ZnO nanorods are grown in the holes.

[OBJECT] To provide an agricultural chemical and the like with the use of an effect of inducing systemic acquired resistance in a plant. To provide a growth inhibitor of not only a plant pathogenic bacterium but also a harmful microorganism.[MEANS FOR RESOLUTION] Utilization of a rare sugar for inducing systemic acquired resistance in a plant or inhibiting the growth of a microorganism. Utilization thereof as an agricultural chemical with the use of the effect of inducing systemic acquired resistance in a plant, a plant disease inhibitor, an inducer of a plant growth regulatory factor (i.e., an inducer of plant hormone-like actions consisting of disease resistance, insect resistance, fruit maturation, breaking of dormancy, regulation of germination, drying resistance, and other than this, resistance to environmental stresses such as low temperature resistance, high temperature resistance, salt resistance and heavy metal resistance and promotion of flowering) and a microorganism growth inhibitor. The rare sugar is an aldose (D-allose, D-altrose or L-galactose) or a ketose (D-psicose or a mixture of D-psicose and D-fructose).

The present invention relates to a cemented carbide comprising WC grains, 3- 20 wt. % binder selected from Co or Co and Ni and grain growth inhibitors wherein the WC mean grain size lies in the range of 180 nm and 230 nm, at least 10+ / -2 % WC grains are finer than 50 nm and 7+ / -2% WC grains have a size from 50 to 100 nm. The invention further relates to a process for production the cemented carbide including the stages of milling WC powder with specific surface area (BET) of 3.0 m<2> / g or higher with binder and grain- growth inhibitors; pressing green parts; pre-sintering the green parts in H2 at 400 DEG C to 900 DEG C for 5 to 30 min; sintering in vacuum at temperatures of 1340 DEG C to 1410 DEG C for 3 min to 20 min; and HIP-sintering in Ar at pressures of 40 to 100 bar at temperatures of 1340 DEG C to 1410 DEG C for 1 to 20 min.

Superfine ceramic thermal spray feedstock compositions and methods of making and using such compositions are provided. In an embodiment, a thermal spray feedstock composition comprises: a superfine ceramic material comprising grains having an average longest dimension of about 100 nanometers to about 500 nanometers; and a grain growth inhibitor comprising a ceramic oxide different from the superfine ceramic material.

The present invention is a method of preventing crystallization of pesticidal compositions during applications by adding a lactate ester as a crystallization preventing agent.

Disclosed is a cholangiocarcinoma cell growth inhibitor comprising an anti-glypican-3 antibody as an active ingredient. Preferably, the anti-glypican-3 antibody has a cytotoxic activity such as an antibody-dependent cytotoxic (ADCC) activity and a complement-dependent cytotoxic (CDC) activity. Also disclosed is a diagnostic agent for diagnosis of cholangiocarcinoma comprising an anti-glypican-3 antibody.

The invention relates to a multi-functional peanut growth inhibitor which is composed by the weight ratio of following components, paclobutrazol to prohexadione calcium to uniconazole is 3: 1.2-1.5: 0.8-1.2. The invention not only can effectively control the growth of the vegetative part of the peanut on the ground, can prevent the peanut from overgrowing and lodging, but also can effectively avoid the side effect brought by general growth inhibitor (e.g. paclobutrazol). At the same time, in the growth anaphase of the peanut, the invention can remarkably improve LAI (leaf area index), effective LAI, leaves membrane-lipid protective enzymatic activity (SOD, POD, CAT), Pr (soluble protein) content and so on, can reduce MDA content and can postpone the senescence rate of peanut leaves. More importantly, the invention can remarkably improve the output of pods. The production can be increased by 16.6 percent- 23.0 percent more than the production without spraying any inhibitor, and can be increased by 7.6 percent- 13.7 percent more than the production only spraying paclobutrazol. The invention solves the problem that the overgrowth and presenility can not be prevented synchronously in the production process of the peanuts.

The invention relates to a method for stunting potted osmanthus fragrans. According to the method, osmanthus fragran varieties with multiple branches and dense internodes are sieved as potted varieties based on the characteristics of indoor pot culture, and the growth potential, branch incidence, branch length, plant shapes and the like of the osmanthus fragrans are controlled effectively by picking bud, pruning and applying a growth inhibitor, so that apical growth is inhibited, the germination of branches is promoted, and the lengths of internodes are controlled; and osmanthus fragran container seedlings of which the height is between 30 and 40 centimeters and the crown diameter is between 35 and 50 centimeters and which bloom are cultivated after three years by reasonable fertilizer and water management, so that the potted osmanthus fragrans are stunted.

The present disclosure relates to bioactive biomatrix compositions. In one embodiment, the biomatrix composition is derived from human amniotic membrane. This biomatrix is ​​called HuBiogelTM. The HuBiogel™ composition precisely mimics the composition of naturally occurring basement membranes and is capable of supporting a variety of cell types in vitro and in vivo. The disclosed HuBiogel™ biomatrix contains laminin, collagen I, and collagen IV in one embodiment, and may further contain any combination of the following: nestin, tenascin, fibronectin, and proteoglycans . The biomatrix composition is substantially free of endogenous growth factors and proteolytic enzymes. The present invention also describes two-dimensional and three-dimensional culture systems and physiological / pathological model systems using HuBiogel™ compositions. HuBiogel(TM) compositions may be modified to contain desired growth stimulators, such as growth factors, polypeptides and small organic molecules, and may also contain growth inhibitory and / or therapeutic agents.

A solid ceramic electrolyte may include an ion-conducting ceramic and at least one grain growth inhibitor. The ion-conducting ceramic may be a lithium metal phosphate or a derivative thereof The grain growth inhibitor may be magnesia, titania, or both. The solid ceramic electrolyte may have an average grain size of less than about 2 microns. The grain growth inhibitor may be between about 0.5 mol. % to about 10 mol. % of the solid ceramic electrolyte.

The invention relates to an environment-friendly lightweight vegetation block, belonging to environment-friendliness and resource recycling. The vegetation block is made by adding mesh-shaped organic plants, waste slurry of a paper-making factory and a growth retardant PP333 to agricultural wastes, urban organic solid garbage and Chinese medicine slag, coal ash and furfural mushroom residues of a factory and water retaining materials recovered from the garbage; and the vegetation block is mainly used for container factory lightweight seedling culture of a forestry flower industry, desertification governance, sand vegetation recovery, landslide vegetation recovery, urban roof greening, cell high-salt field greening and planting of a football field and a golf course. According to the invention, not only raw material resources is protected, the function of ecosystem balance is increased, and the efficiency of plantation is improved, but also an effective resource recycling path for urban household garbage, agriculture and forestry wastes and factory organic garbage is found out so that renewable resources are subjected to highly economic optimization combination and are more utilized effectively and reasonably.

The invention relates to a method for regulating flowers and spikes of Feizixiao litchis, belonging to the field of application of litchi production technology. The best method for gaining high and stable yields is to reduce the number of flowers and delay the time of flowering as the Feizixiao litchi variety is easy to flower, the number of flowers is great, the flowering needs to consume a great deal of nutrition and influence the rate of bearing fruit, and the fruit bearing is influenced by weather; the method comprises the steps: when spikes of Feizixiao litchis grows by differentiation to be 10-15 cm long in January and February, a growth retardant uniconazol with concentricity of 50-100ppm is used for postponing the growth of the spikes and restraining the premature growth of the spikes of Feizixiao litchis; after the method is adopted to treat the spikes, the premature growth of the spikes can be restrained to lead the spikes to become short and strong and greatly reduce the number of flowers, thus omitting heavy and nervous work for flower thinning for the Feizixiao litchis; and the flowering time of the Feizixiao litchis is postponed at about spring equinox, thus achieving the purpose of one-time flowering and bearing fruit, greatly improving rate of bearing fruit, and being compact in spikes, uniform in size of fruits and consistent in mature period.

The invention provides a regulation and control method enabling potted Arabian jasmine to bloom during the Spring Festival. The method comprises the steps of trimming potted Arabian jasmine 50-60 days before the Spring Festival, keeping the lowest 1-2 stem nodes of 1-2-year old branches and cutting the rest; cultivating the trimmed Arabian jasmine in an environment meeting the conditions of daytime temperature of 28 DEG C-32 DEG C, illumination intensity of 35-50 micromole / m<2> / s<1>, illumination time of 12-14 hours and night temperature of 18 DEG C-22 DEG C; applying thin cake fertilizer water or compound fertilizer once 5-10 days before trimming and 5-10 days after trimming to improve the growth vigor, spraying a growth retardant PP333 once 7-14 days after trimming to prevent spindling of young spouts, and spraying a monopotassium phosphate water solution once 21-28 days after trimming to promote flower bud differentiation and growth. The method solves the problem that Arabian jasmine cannot bloom in winder under natural conditions, can reliably and effectively regulate and control the flower phase of potted Arabian jasmine and enables the potted Arabian jasmine to bloom normally during the Spring Festival.

The present invention provides a method of forming particles using supercritical fluid (SCF). In accordance with the method, one or more growth retardant compounds having both SCF-philic and SCF-phobic groups are present when one or more solute materials reach a supersaturation point and begin to form particle nuclei. The growth retardant compounds can reduce the particle growth rate, increase the nucleation rate and also prevent particle agglomeration. Preferred growth retardant compounds include sugar acetates and fluorocarbons.

The invention discloses a green preparation method of sea urchin shaped nanogold and application of the nanogold in tumor imaging and treatment. Chloroauric acid is mainly used as a gold source, a stabilizer, a reducing agent and a growth inhibitor are successively added, and the nanogold is prepared by adopting a one-step synthesis method. The method is simple, mild, green and friendly to the environment. The synthesized sea urchin shaped nanogold can serve as a contrast agent to be applied to multiple medical imaging modes such as opto-acoustic imaging (PA), positron emission computed tomography imaging (PET) and infrared thermal imaging (TI), patients can obtain multiple diagnostic effects only by needing to bear one contrast agent for dose, the dosage of contrast agent can be reduced, and the toxic and side effects are thus reduced. In addition, the material can achieve conversion of light and heat under near-infrared light irradiation of 808 nm, can absorb a large number of X rays, has higher light-heat conversion efficiency, and can be used for the preparation of a therapeutic agent for light and heat treatment (PTT), radiotherapy (RT), or combined therapy of PTT / RT of tumor cells.

The present invention revealed that AT-264 suppresses cell growth through its inhibitory effect on PepT1 activity. Furthermore, as a result of examining whether AT-264 comprises the effect of inhibiting the cell growth of human pancreatic cancer cell line AsPC-1, the present invention revealed that cell growth is similarly suppressed. These findings show that cell growth can be suppressed by inhibiting the activity of peptide transporters. Suppression of peptide transporter activity can be considered to be an important indicator in the development of growth inhibitors for cancer cells and such.