5 results about "Endothelial progenitor cell" patented technology

This invention relates to an intravascular blood flow guiding device with an endothelialization-promoting coating. After the coating is applied to the surface of the blood flow guiding device, it can regulate the biological functions of circulating endothelial progenitor cells within the blood vessel, including promoting oriented extracellular matrix formation, promoting cell-extracellular matrix adhesion, and promoting endothelial cell proliferation and maturation. This results in: enhanced adhesion, proliferation, and migration capabilities of endothelial progenitor cells; significantly improved acceleration of the endothelialization process; excellent anti-platelet and anti-SMC adhesion properties; and, combined with the hemodynamic optimization effect of the blood flow guiding device, accelerated functional remodeling of the tumor-bearing artery.

This invention discloses the application of induced pluripotent stem cell (EPC) derived from induced pluripotent stem cell differentiation in the preparation of stroke therapeutic agents. Through intravenous injection of EPCs into an animal model of stroke, this invention demonstrates that this method can treat stroke by inhibiting atherosclerosis, reducing cerebral infarction levels, promoting angiogenesis in lesioned brain tissue, improving inflammatory responses in lesioned brain tissue, and repairing nerve damage and brain injury. The above research results of this invention provide a new treatment method for stroke in clinical practice.

The application relates to the technical field of biological medicine, and discloses an engineered exosome, a preparation method and purposes thereof. The method comprises the following steps: introducing an exogenous nucleic acid coding a human TIMP3 protein into endothelial progenitor cells to construct engineered cells, and obtaining exosomes by separating and purifying the supernatant after culture. The engineered exosome is secreted by the endothelial progenitor cells and is efficiently loaded with the TIMP3, and has both cell homing characteristics and protease inhibition functions. The exosome can significantly inhibit matrix metalloproteinase 3 (MMP3) activity, reduce extracellular matrix degradation, and improve the structural stability of a blood vessel wall. The application provides a novel and efficient cell-free delivery strategy for treating aortic dissection, aneurysm and other vascular remodeling diseases.

Method for producing a three-dimensional human multiple myeloma model. The present invention relates to a method for producing a three-dimensional (3D) model of multiple myeloma (MM), in the form of spheroids, by co-culturing mesenchymal stem / stromal cells, endothelial progenitor cells, and primary plasma cells from MM patient(s). The present invention also relates to the spheroids obtained by said method and their uses. Figure for abstract: none

The application belongs to the technical field of medical devices, and discloses a tibial periosteum embedded air bag stimulation device and method, which comprises a stimulation air bag, a gas storage and driving assembly and a power supply assembly. The stimulation air bag is implanted between the tibia and the periosteum, and the surface of the stimulation air bag is provided with ribs in the same direction as the long axis of the stimulation air bag. The stimulation air bag is respectively provided with an air inlet pipe and an air outlet pipe for air intake and exhaust. The gas storage and driving assembly comprises a gas storage bag and a gas pump. The gas storage bag is in communication with the air inlet pipe and the air outlet pipe. The air inlet pipe is connected in series with the gas pump and a first electromagnetic valve. The air outlet pipe is provided with a second electromagnetic valve. The power supply assembly, the gas pump, the first electromagnetic valve and the second electromagnetic valve are electrically connected with a main control board and are all packaged in a packaging assembly. The stimulation air bag is placed between the tibia and the periosteum to directly stimulate the inner layer of the periosteum rich in vascular endothelial progenitor cells and activate the potential of neovascularization through mechanical stimulation. The mechanical stimulation effect is enhanced through the convex ribs. The main control board is used for control without the intervention of the patient.