100 results about "Research findings" patented technology

The invention belongs to the technical field of microalga biology, and particularly relates to a microalga strain with high CO2 tolerance and high fixation rate and a breeding method thereof. The microalga is named Chlorella sp.Y-1, and is collected into Common Microorganism Center of China General Microbiological Culture Collection Committee; and collection number is CGMCC No.5429. The invention has the following characteristics: the initial strain is separated from natural environment; after high-CO2-concentration enrichment culture, gene cloning, induced mutation breeding and other operations, the carbon content of the target strain is increased to 56.981%, the optimal fixation concentration is up to 20% (v / v), the fixation rate is up to 5.762g / (L.d), and the maximum tolerance concentration is 100% (v / v); and the target strain has high adaptability to a series of physical and chemical culture conditions, has high culture transfer stability, and high better overall properties than the like research findings at present. The invention aims to solve the bottleneck problem in high concentration CO2 biological fixation technology, cultures an efficient organism capable of efficiently fixing high concentration CO2, implements effective fixation of CO2 in high concentration flue gas and other complex environments, and meanwhile, generates beneficial biological substances.

The invention relates to a continuous type low-temperature boiling-off and bleaching pretreatment process of full-cotton woven fabric. At present, the low-temperature boiling-off and bleaching of pre-treatment process exists, but are only the pre-treatment processing process for cotton and blended knitted fabric; research findings or patent documentation of pre-treatment process taking low-temperature boiling-off and bleaching of full-cotton woven fabric are not found at present. In the invention, hot water pre-treatment processing, biological enzyme processing, hot water washing and enzyme blanching and water washing process are firstly preformed on the full-cotton woven fabric, and then the low-temperature scouring and bleaching processing, the low-temperature steam bleaching processingand the water washing process are then performed to finish the pre-treatment of the cotton woven fabric. In the invention, the cotton woven fabric is pre-treated in combination with biological enzymedesizing and the low-temperature scouring and bleaching; the technology in the invention has a good effect without sizing agent residuals and residual cotton seed hulls, and the brightness achieves the effect of the traditional soda boiling and oxygenation bleaching technology.

The invention belongs to the technological field of the Chinese medicine, particularly relating to an extraction and separation processes of the active ingredients with the active function of treating the chronic glomerulonephritis. The mullein indican is the active compound researched and developed for many years in our research institute; the mullein indican is extracted, separated and refined from the digitalis leaf and is an active compound with the function of treating the chronic glomerulonephritis. The invention is the research result of many years held and developed by the Chinese Medicine Research Department of the Chinese Medicine Research Institute of China and is supported by the special fund of the Central Institute of the National Science and Technology Department; now the compound has been approved by the State Food and Drug Administration Bureau as the novel drug and the mechanism research of the treatment of the chronic nephritis has been completed; the pre-clinical research work includes the main pharmacodynamic experiment, the production technology experiment (including the industrialized extraction and separation processes), the quality control standard, the experiment of the affecting factors of the quality, the experiment of the long-term stability, the acute toxicity of the rat, the experiment of the long-term toxicity, the teratogenic and mutagenic experiment, the general pharmacological experiment, the pharmacokinetics experiment, and so on. The digitalis leaf is mainly produced in the Huaiqing area of the Henan province, and is also grown wild and cultivated in the Shaanxi, Hebei and other places of China.

The invention discloses a novel method for preparing and modifying a polyimide nanofiltration membrane used for a benzol-ketone dewaxing lubricating oil solvent organic-solvent-resisting polyimide nanofiltration membrane through an inorganic salt pore-forming agent. Research findings show that if a small amount of inorganic salt ZrCl4 is added to polyimide materials, proper chemical cross-linking modification is conducted on the inorganic salt ZrCl4 and the polyimide materials, and the nanofiltration membrane which is good in solvent resistance performance and has high reject rate and flux to ketone-benzol dewaxing lubricating oil is obtained. Under the operation pressure of 3MPa, the reject rate of the polyimide nanofiltration membrane to the benzol-ketone dewaxing lubricating oil can reach up to 99% and the flux of the polyimide nanofiltration membrane to the benzol-ketone dewaxing lubricating oil can reach up to 44L*m<-2>*h<-1>.

The invention belongs to the technical field of disease and insect pest prevention and control for fruit trees, and particularly relates to a fruit tree insect prevention technology by the aid of covers. The fruit tree insect prevention technology is characterized in that according to research findings on fruit setting characteristics of different varieties of fruit trees and activity rules of injurious insects on the fruit trees, when single fruit trees or in-line fruit trees or vast fruit trees which have different fruit setting characteristics and the injurious insects with different activity rules are specifically protected by the covers in proper periods, fruits can be isolated from the injurious insects and are effectively prevented from being harmed by the injurious insects, the photosynthesis of the fruit trees is hardly affected by selected cover materials, obvious influence of the selected cover materials on the temperature and the humidity required by each fruit tree is prevented, and a physical protection layer can be provided for each single fruit tree, the in-line fruit trees or the vast fruit trees; simple supports of the covers comprise upright columns (timber piles or steel tubes) and drawn steel wires, and the covers can be shifted as needed, can be operated easily and conveniently and are economical and durable. The fruit tree insect prevention technology has the advantages that dependence on pesticides for pest control and corresponding pesticide and labor cost input can be greatly reduced for fruit growers, the commodity rate of the fruits is increased, and the safety of the fruits is improved.

The invention discloses an application of miR-3613 as a miRNA marker in distinguishing metastasis and non-metastasis of lung squamous carcinoma. Accordingly, the miR-3613 can be used for developing products for diagnosing lung squamous carcinoma metastasis and drugs for treating lung squamous carcinoma metastasis. The research result of the invention provides a theoretical basis for making individual-based treatment schemes by clinical physicians and can provide a new drug target for developing lung squamous carcinoma drugs.

The invention provides a weight-reducing meal replacement powder for obesity patients. The formula of the powder is developed, combined with the physical characteristics of obesity patients, combinedwith the present advanced research findings of Harvard University of U.S. on physiology, medicine, nutriology and clinical application, and according to quintessence theories of "relieving stomach heat for supplementing" and "balanced recuperating" (a main principle is that three organs including the liver, spleen and kidney are simultaneously conditioned) of traditional Chinese medical science. The product is prepared by using main raw materials of more than ten new resource foods, medicinal and edible traditional Chinese medicine extract essence and probiotics, and auxiliary materials of short chain polypeptides, water-soluble dietary fibers, mixed fruit powder, coarse cereal powder, compound vitamins and compound minerals. The powder can not only meet the nutritional requirements of obesity patients as a single nutrient source, but also has the effects of burning fat for reducing weight, moistening intestines, relaxing bowels, clearing heat and toxic materials, expelling toxins, beautifying skins and preventing and treating obesity.

The invention relates to a multifunctional type high-temperature-resistant composite well control fluid. The well control fluid comprises the following components in parts by weight (the weight part sum of all components is 100): 3-5 parts of quaternary ammonium salt cationic polymer, 1-3 parts of thickener, 2-4 parts of high-temperature-resistant leak-off agent, 15-60 parts of density modifier, 1-3 parts of auxiliaries, and the balance of water. The invention further provides a preparation method of the multifunctional type high-temperature-resistant composite well control fluid. Research findings prove that the well control fluid has multiple excellent effects, can be used for petroleum exploration and development, and has good industrial application potential and market values in industry.

The invention relates to the technical field of pharmaceuticals, and more particularly to application of a propolis ethanol extract in preparation of medicaments, food and health care products for prevention or treatment of inflammatory bowel diseases. The propolis ethanol extract is obtained by extraction by using 80 to 95% ethanol as a solvent. Research findings show that the propolis ethanol extract can inhibit the health state of a body during the development course of ulcerative colitis, reduce the shortening of the length of the colon, and improve the pathological structure of a colon tissue; therefore, the propolis ethanol extract can be applied to development of medicaments, health care products and food for prevention or treatment of the ulcerative colitis.

The invention relates to the technical field of lung cancer gene detection, in particular to an ANXA3 gene or an ANXA3 protein as a biomarker of lung adenocarcinoma. Research findings, ANXA3 gene wasabnormally expressed in lung adenocarcinoma in both Xuanwei and non-Xuanwei areas. The expression of ANXA3 gene was lower or higher than normal level. ANXA3 gene or protein could be used as biomarkerof lung adenocarcinoma to diagnose lung adenocarcinoma, judge lymph node metastasis, assist TNM staging and prognosis. The invention provides an ANXA3 gene and an expression product thereof in preparation for prejudging whether lymph node metastasis of lung adenocarcinoma, The present invention provides a new diagnostic method for clinically diagnosing metastasis of lung adenocarcinoma and provides a new candidate drug for treating metastasis of lung adenocarcinoma. The present invention relates to a method for treating metastasis of lung adenocarcinoma and a pharmaceutical composition for treating lung adenocarcinoma.

The invention provides a medical formula food capable of neutralizing the effect of alcoholic drinks and dispelling the effects of alcoholic drinks, which is suitable for patients suffering from alcoholic diseases to eat. According to the requirements of the ''General Rules for Formula Foods for Special Medical Purposes'', through combination of the constitution characteristics of the patients suffering from alcoholic diseases, integration of research findings of advanced physiology, medicine, nutriology, clinical application and the like of Harvard University in the United States at present,and based on conventional traditional Chinese medical science quintessence theories of combining supplementing with eliminating, and balancing and regulating (regulating three organs of the liver, thespleen and the kidney at the same time), the medical formula food is developed. Various medicinal and edible traditional Chinese medicine extract essences, various probiotics and short chain polypeptides are used as main raw materials of the medical formula food, prebiotics, carbohydrate, amino acids, multivitamins and minerals are used as auxiliary materials, and the medical formula food is prepared by mixing the main raw materials with the auxiliary materials. The medical formula food not only can be used as a single nutrition source to meet nutrient requirements of the patients suffering from alcoholic diseases, but also have the efficacy of invigorating the liver and the spleen, clearing heat, removing toxicity, promoting the circulation of qi, regulating the function of the stomach,eliminating alcoholic dampness, removing alcoholic heat, relieving alcoholism and enhancing immunity.

The invention discloses an SNP (single-nucleotide polymorphism) marker of a wheat grain weight gene TaGS5-3A and an application of the SNP marker. The application specifically refers to the application of the SNP at a following SNP locus in a wheat genome to identification or auxiliary identification of related traits (grain weight and / or grain length and / or grain width and / or grain thickness) of to-be-detected wheat grains, wherein the SNP locus refers to the 718th nucleotide from 5' end of an amplification product obtained through PCR (polymerase chain reaction) amplification performed with DNA (deoxyribonucleic acid) of the wheat genome as a template and with adoption of a primer pair, and the nucleotide at the SNP locus is T or G; the primer pair is formed by a single-stranded DNA shown in a sequence 1 in a sequence table and a single-stranded DNA shown in a sequence 2 in the sequence table. Research findings show that a TaGS5-3A-T allele has significant or very significant positive correlation with the wheat grain weight, grain length, grain width and grain thickness; meanwhile, the SNP marker is a codominant marker, has good repeatability and low cost and has broader application prospect in wheat assisted selection and molecular design breeding.

The invention discloses researches on mechanism of action of polyether compounds in anti-tumor. The drug is used for acting on at least one of the following signal pathways through induced apoptosis by affecting calcium, mediated apoptosis by affecting intracellular reactive oxygen species (ROS) level and mediated apoptosis by affecting cytochrome C level of cell mitochondria. The polyether compounds can cause death of tumor cells through controlling multiple signal pathways, and thus, the anticancer effects can be better achieved.

The invention provides a traditional Chinese medicine for curing constipation and a preparation method thereof. The medicine is an oral administration medicine, preferably a capsule prepared from astragalus root, semen plantaginis, rhubarb (wine processing), desertliving cistanche, seabuckthorn oil, radix cyathulae and semen cassiae by combining a traditional Chinese medicine theory and a latest pharmacological research result and using a modern technology means. A pharmacodynamic experimental study indicates that the medicine has a good function of curing the constipation. Because raw materials adopted by the medicine are all derived from a natural medicinal plant with homologous functions on medicines and foods, the medicine is safe and reliable to take, has high clinical application value and is greatly suitable for the current market demand.

The invention discloses application of SPARCL1 to a diagnosis and treatment marker of endometrial cancer. The SPARCL1 can be used for developing a product for diagnosing the endometrial cancer and developing a medicine for treating the endometrial cancer. A research result of the invention provides a theoretical foundation for formulating personalized treatment programs by clinical doctors and provides a new medicine target spot for developing endometrial cancer medicines.

A household amblyopia pleoptic therapy and an apparatus thereof are based on the traditional vision stimulation therapy and combines the modern vision physiological study result; under the technical level of light, sound, electricity and digital control, the present invention integrates the direct stimulation of a characteristic light source towards the vision and the indirect stimulation of a sound signal towards the visual cortex organically by the united space sensing exercising action of the eye-hand-pallium of the patient, which ensures that the synchronized activity of the cortical cell input by the amblyopia eye is increased, so as to release the level restriction of the vision at the pallium, promote the vision growth and realize the effective treatment of the amblyopia finally. The clinical observation for a plurality of years shows that the amblyopia pleoptic therapy and the apparatus of the present invention are safe and reliable and the curative effect is good.

The invention discloses a modification method for in situ polymerization of pyrrole on surfaces of carbon fibers. The method comprises the following steps of: 1) at the temperature of 10 DEG C below zero to 60 DEG C, mixing the carbon fibers with a pyrrole aqueous dispersing liquid, wherein the mass ratio of the carbon fibers to pyrrole is (2-2000): 1 and the mass ratio range of water to carbon fibers is 2-10; putting the mixture which is mixed, wherein the surfaces of the carbon fibers are in full contact with pyrrole monomers and the pyrrole monomers are adsorbed to the surfaces of the carbon fibers; 2) adding a solution of an oxidant to realize chemical oxidizing polymerization, wherein the molar ratio of the oxidant and the pyrrole monomers is 1: (0.05-3), and performing a continuo reaction at the temperature of 10 DEG C below zero to 30 DEG C; 3) after reaction, adjusting the pH value till the mixture is neutral; and 4) taking the carbon fibers out of a reaction liquid, rinsing the carbon fibers with clean water, draining off moisture, and drying to obtain a carbon fiber / polypyrrole composite material. The polypyrrole has very good biocompatibility, and through research finding, polypyrrole combined with a carrier has a very good adsorption characteristic due to a doping-de-doping characteristic, so that the composite material has broad spectrum adsorption on pollutants in sewage.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of polyacetylene to lowering of uric acid. A polyacetylene compound has a structure shown in a formula (I): R1 and R2 are defined as in the specification. According to the new application of the polyacetylene to lowering of the uric acid, as for research findings, the polyacetylene compound separated from coreopsis tinctoria has the characteristics of lowering the activity of the uric acid and no obvious toxic and side effects, and can be used for treating hyperuricemia and gout orgout complications caused by hyperuricemia.

The invention relates to an amblyopia vision increase treatment method and the system, which combines the modern visual physiology research results on the basis of the traditional after-image vision increase therapy, the invention can allow patients to organically integrate the direct stimulation of a characteristic light source on the vision and the indirect stimulation of the sound signal on the visual cortex by the eyes-hands-brain cortex combined space perception and the central vision fixation training actions on the light, sound, electric and data controlled technical lever, so as to strengthen the synchronous activities of the input cortex cells of the amblyopia eye, further to relieve the suppression of the vision on the brain cortex level, promote vision development and finally realize the effective treatment of amblyopia. The clinical observations of 2 years show that the improved after-image vision increase therapy is an amblyopia treatment method which is safe, reliable and good in efficacy, and the invention especially has the treatment effect which is significantly better than other methods for the non-center watch type and other refractory amblyopia. The system can not only greatly improve efficacy, but also improve the working conditions of the medical staff and enhance working efficiency.

The invention relates to an HLH transcriptional regulator BmHLH2 applied to special expression of domestic silkworm silk gland. The HLH transcriptional regulator BmHLH2 is obtained by a series of biotechnology clones such as analyses of an expression profile of silk gland genes, manufacturing, hybridization and data analysis of genetic chips and the like. The HLH transcriptional regulator obtained in the invention is a novel transcriptional regulator applied to the special expression of the domestic silkworm silk gland, fluorescent quantitative PCR experiment indicates that the transcriptional regulator has important links with the development of the silk gland and differentiation of silk gland cells; an intervention study on the BmHLH2 gene indicates that the HLH transcriptional regulator plays a very important role in regulating and controlling cell differentiation, specialization of organs and the special expression of genes. The research findings are of great significance in improving silk qualify and quantity of domestic silkworms and promoting the development of silk industry.

The invention provides food, health care product or medicine composition. The composition comprises raw materials in parts by weight as follows: 1-3 parts of Morchella and 4-10 parts of kudzuvine root starch or kudzuvine roots, wherein the Morchella is selected from Morchella fruiting bodies or Morchella mycelia. The invention further provides a preparation method and an application of the composition. According to research findings, the yang tonifying effect of the Morchella is improved after the Morchella is combined with the kudzuvine root starch for use, so that the kudzuvine root starch plays a role in promoting the yang tonifying effect of the Morchella; besides, the two raw materials can be used as food and are extremely high in safety, and a new choice is provided for clinical medication.

The present invention discloses a specific full-nutrient formula food for consumption by stroke patients. The formula is developed according to the requirements of Food for Special Medical Purpose, according to the physical characteristics of stroke patients, according to the present research findings of American Harvard University on advanced physiology, medicine, nutriology and clinical application in USA Harvard University, and according to a quintessence theory (a main principle is that three organs including liver, spleen and kidney are simultaneously conditioned) of traditional Chinese medical science that "relieving stomach heat for supplementing" and "balanced recuperating". The product is prepared by mixing a plurality of medicinal and edible traditional Chinese medicine extract essence, a plurality of probiotics and short chain polypeptides as main raw materials, and prebiotics, carbohydrates, amino acids, fat powder, multivitamins and minerals as auxiliary materials. In addition, the present invention also provides a method for preparing the specific full-nutrient formula food for consumption by stroke patients. The food can not only meet the nutritional requirements ofstroke patients as a single nutrient source, but also has the functions of inhibiting neuronal apoptosis, improving immunity and regulating gastrointestinal tracts.

The invention discloses a sterilization method of fruit and vegetable juice. The sterilization method comprises the following steps: subjecting fruit and vegetable raw materials to pretreating, stripping and slicing and cold pressing: selecting fresh, moderately-ripe and non-damaged fruit and vegetable materials, carrying out cleaning, stripping and slicing the cleaned materials into 1-3 cm<3> insize, and carrying out cold pressing at 0-8 DEG C with pulp temperature controlled at 15 DEG C or below; carrying out a high-pressure homogenization treatment: pressure 120-200 MPa, feeding temperature 25-40 DEG C and homogenization times 1-3 times, and cooling the materials to 4 DEG C after the high-pressure homogenization treatment; carrying out thermosonication treatment: power 200-600 W, temperature 45-58 DEG C and time 5-30 minutes. According to the invention, research findings show that the high-pressure homogenization treatment can synergize with the thermosonication treatment, with thewhole processing temperature being 52 DEG C or below and the total processing time being only 5 minutes, so that the sterilization method ensures sensory characteristics, quality, solid matter contents, betacyanins, total sugar, fruit grain suspension stability and other characteristics of the fruit and vegetable juice, and has a good sterilizing effect to completely kill pathogenic bacteria at the same time.

The invention provides an imidafenacin film-coated tablet. The imidafenacin film-coated tablet comprises raw and auxiliary materials in parts by weight as follows: 1-5 parts of imidafenacin, 700-850 parts of pregelatinized starch, 600-700 parts of microcrystalline cellulose, 3-6 parts of lubricants and appropriate coating agents. The invention further provides a preparation method of the film-coated tablet. According to research findings, the imidafenacin can dissolve completely even in 5min in a specific prescription ratio of the tablet; meanwhile, a specific fluidized bed granulation process is adopted, so that the uniformity of the content of the imidafenacin in the preparation can be remarkably improved; and the content of main drugs in the imidafenacin tablet is quite low, so that the quality uniformity of drugs is well guaranteed with the preparation method.

The invention provides a memory promotion health-improving food and its preparation method in the technical field of health-improving food. The invention relates to the oral health-improving food that is prepared with ingredients such as rhizoma gastrodiae and asiatic centella in the mode of capsule, tablet and pill by utilizing traditional Chinese medical principles, latest pharmacological research achievement and modern technique. After the pharmacodynamic experiment, it is proved that the health-improving food functions well in improving memory. Besides, because natural medical plant is adopted in the health-improving food, the invention realizes excellent security, reliability and clinic application value after being taken for a long time. Therefore, the invention meets well with the market demand at present.

The invention provides application of antibacterial peptide in preparing drugs for treating helicobacter pylori and a drug composition, and relates to the field of drugs. According to research findings, the inventor discovers that antibacterial peptide with the amino acid sequence being shown as SEQ ID NO:1 has the strong killing activity on helicobacter pylori, and can serve as an active ingredient to prepare the drugs for treating helicobacter pylori diseases. The drug composition is prepared from the antibacterial peptide and honey, because honey can enhance the activity of the antibacterial peptide in killing helicobacter pylori, and thus the drug composition has a more prominent effect on resisting helicobacter pylori.

On the basis of analysis on the existing research findings of the traffic volume forecasting method, the invention provides a combination forecasting method for urban road section traffic flow characteristics. The method comprises the following steps: 1) actually-measured data of the urban road section traffic volume are gathered, sorted and analyzed, according to a forecasting time interval inter, an actually-measured traffic volume fluctuation index ind(i,j) at each time interval opn each day in history is calculated, and the mean value ind(i) is calculated; 2) according to the actually-measured recent daily traffic volume of the urban road section, a gray forecasting model GM(1,1) is used to forecast the daily traffic volume on a (q+1)th day; and 3) according to actually-measured data of former p time intervals on the (q+1)th day, a time series forecasting method is used to forecast the section traffic volume at a (p+1)th time interval. Based on long-term actually-measured data, theforecasting method makes full use of the urban traffic flow change law and multiple forecasting methods are used; and the forecasting result can reflect the urban road traffic dynamic change trend and can also flexibly respond to short term fluctuation of the traffic flow.

The invention belongs to the technical field of a network information platform, and particularly relates to a research finding transformation platform structure which is perfect in function, good in informatization and strong in timeliness. The structure comprises clients, a data end and a background management server. The clients are portal servers. The data end comprises a memorizer, an exchanger, a data base server, an application program server and a backup server. One end of the background management server is connected with a first portal server and a second portal server, and the other end of the background management server is connected with the data base server, the application program server and the backup server. The data base server, the application program server and the backup server are connected at one end of the exchanger together, and the other end of the exchanger is connected with the memorizer.

The invention provides an identification method for liver cancer stem cells. According to research finding, LCSC (liver cancer stem cells) can express the unique protective proteins intracellularly orextracellularly under the certain induction condition; based on the beneficial finding, the invention further studies the specificity and the sequence signature of the proteins, and obtains two protein segments which have the good specificity on liver cancer cells and common liver cells through screening, and the test verifies that the proteins are only stably expressed in LCSC while do not existin common liver cancer cells, therefore the proteins can serve as a marker for identifying LCSC. On the basis, the invention optimizes the cell induction method aiming at ensuring the expression quantity and the stability of the protein segments, and by using the method to induce cell samples, not only can the stable expression of the marker protein be ensured, but also the expression quantity and the LCSC cell content present a good linear relation; and based on the rule, relative quantitative analysis of the LCSC cell content can be achieved.

The invention provides application of LINC01703 as a molecular marker for liver cancer diagnosis. Researches of the invention shows that LINC01703 has significant differences in expression in liver cancer tissue and para-carcinoma tissue; it is considered accordingly that LINC01703 may serve as a molecular marker for the diagnosis of liver cancer. Products suitable for early diagnosis of liver cancer can be developed according to the results of the researches above; the products have high detection rate and are suitable for clinical popularization.