The invention discloses a multi-
omics data integration and classification method,
system and device based on hierarchical attention, and is applied to the field of precise medical
big data analysis. The method comprises the following steps: firstly, generating feature embedding and feature importance scores through a plurality of parallel feature-level attention modules; then, embedding and inputting all the characteristics of the
omics into a unified
omics-level attention module, and generating omics embedding and omics importance scores; and finally, a classification prediction task is executed based on omics embedding, and a
classification result is output for
disease classification. The invention completely abandons a traditional
dependency graph convolutional network and an integration normal form of variants of the
dependency graph convolutional network, and provides a universal hierarchical attention integration architecture. The framework supports classification tasks of any complex diseases, is not limited by
omics data types and combination
modes, not only is remarkably superior to a traditional integration normal form in classification performance, but also shows a unique negative generalization distance, and proves that the framework has excellent generalization ability. Meanwhile, features and omics importance scores automatically output by the model provide a powerful analysis tool for
biomarker discovery and precise diagnosis and treatment of complex diseases.