49 results about "Baicalin" patented technology

This invention relates to diselenylene-bridged mesoporous silica nanoparticles loaded with baicalin and their applications. The invention constructs a ROS-responsive, microglia-inspired Ba@Se-MSN&BV2 nanoplatform targeting the secondary phase of spinal cord injury. The BV2 cell membrane-mediated enrichment at the injury site, combined with the diselenylene-triggered, on-demand release of baicalin, enables targeted intervention in a highly oxidative and pro-inflammatory microenvironment. In vitro and in vivo studies show that Ba@Se-MSN&BV2 can alleviate oxidative stress and mitochondrial dysfunction, inhibit apoptosis, promote axonal and neuronal survival, and improve motor circuit function. This invention provides a new therapeutic target and research direction for neuroinflammatory injuries driven by redox homeostasis disruption, with significant clinical application prospects and social value.

The application discloses a baicalin ternary co-amorphous drug and a preparation method and application thereof, and the amorphous substance can effectively improve the solubility and dissolution of puerarin and baicalin. The application mixes metformin hydrochloride, puerarin and baicalin according to a molar ratio of 1:1:1, and obtains the baicalin ternary co-amorphous drug through a ball milling method or a solvent-assisted milling method, the preparation method is green and efficient, the co-amorphous substance has high light stability and thermal stability, the solubility is increased by 1.7 times compared with that of a puerarin raw drug crystal, the solubility is increased by 46.8 times compared with that of a baicalin raw drug crystal, and the solubility is reduced by 14.8 times compared with that of a metformin hydrochloride raw drug crystal. The baicalin ternary co-amorphous drug has certain application prospects in liver protection, blood sugar reduction, treatment of damp-heat type colitis and cervical cancer.

The application discloses a preparation method of a hydrocolloid dressing for oral cavity, and relates to the technical field of medical supplies. Baicalin extract and a polyvinyl pyrrolidone solution are mixed to obtain a baicalin extract solution; chitosan fibers, hydroxymethyl cellulose and the baicalin extract solution are mixed to obtain a mixed solution; vacuum degassing: the prepared mixed solution is vacuumized, pressure is maintained, and primary degassing is performed; ultrasonic degassing: the mixed solution after primary degassing is subjected to ultrasonic degassing; static degassing: the solution after ultrasonic degassing is sealed by using a preservative film, and is subjected to secondary degassing at room temperature; a PU film is fixed in a film laying frame, the degassed mixed solution is poured into the film laying frame, and the film laying frame is placed into an air-blowing drying box to solidify and form a protective layer, so that the hydrocolloid dressing is obtained. The hydrocolloid dressing prepared by the method has good adhesion, can be used on a wound for a long time, and can effectively promote the repair of damaged cells and wounds, so that the healing of the wound in the oral cavity is promoted.

This invention belongs to the field of baicalin crystallization technology, and relates to a leaf-shaped baicalin crystal, its preparation method, and its application. The crystal has a leaf-like microstructure with a length ranging from 1 μm to 17 μm; the bulk density of the crystal is 0.1-0.2 g / mL, and the compactness is 0.2-0.4 g / mL. The leaf-shaped baicalin crystals provided by this invention are easy to compress into tablets and have a high surface area / volume ratio, which is beneficial for its adsorption and dissolution in vivo. The preparation process is simple to operate and can directionally prepare leaf-shaped baicalin crystals. The purity of the obtained leaf-shaped baicalin crystals can reach 93% or higher, significantly improving the chemical purity and forming a unique low bulk density physical property.

To provide a skin cosmetic composition that exhibits excellent anti-inflammatory effects on the skin by increasing the production of IL-1ra, which prevents inflammatory signaling to cells. [Solution] (A) Curcumin and, (B) Contains baicalin, The skin cosmetic composition is characterized in that the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a pharmaceutical composition for recurrent urinary tract infection and a preparation method thereof. According to the invention, a compound extract for warming yang, promoting diuresis and activating blood and baicalin are synergistically compounded in an ion composite network formed by sodium alginate and chitosan, and are subjected to shear dispersion or homogenization treatment to form ion composite nanoparticles, and then the ion composite nanoparticles are subjected to calcium chloride cross-linking solidification and chitosan coating to prepare a multi-layer synergistic carrier design of the pellet; the dispersion uniformity, the forming strength, the pH response release and the storage stability of the ionic composite nanoparticles under the condition of high drug loading capacity are realized, and the core contradiction that the mechanical strength, the in-vivo swelling response release and the low-water-content storage and transportation stability are difficult to consider at the same time in the existing calcium alginate carrier system is solved; the method has wide clinical application value in comprehensive prevention and treatment of recurrent urinary tract infection.

The invention relates to the technical field of medicines, in particular to a preparation method and application of a baicalin self-microemulsifying preparation taking ginsenoside as an effective auxiliary. The baicalin self-microemulsifying preparation is prepared by innovatively adding the natural medicine ginsenoside with various known pharmacological activities as one of the effective auxiliary agents, so that the problem of low solubility of the baicalin can be improved, and the oral availability of the baicalin is improved by 4.38 times; and compounding of two natural medicine components with definite biological activity on preparations is realized, and a basis is provided for clinical application of baicalin as a medicine.

The invention discloses a construction method and application of a scutellaria baicalensis stem and leaf fingerprint spectrum, and belongs to the technical field of medicine quality control. The method comprises the following steps: preparing standard substance solutions of scutellarin, baicalin, taxifolin and isoschaftoside; preparing a scutellaria baicalensis stem and leaf sample solution; detection is carried out under specific conditions through high performance liquid chromatography, a standard fingerprint spectrum of the stems and leaves of scutellaria baicalensis is made by taking a standard chromatographic peak as a reference, and the relative standard deviation of the relative retention time does not exceed + / -20%. The method disclosed by the invention is high in precision, good in stability and excellent in repeatability, effective separation of four flavonoid components can be realized within 35 minutes, and the quality characteristics of stems and leaves of scutellaria baicalensis are comprehensively reflected. The invention further provides application of the fingerprint spectrum in quality analysis of the scutellaria baicalensis stem and leaf medicinal material and the extract thereof, and reliable technical support is provided for resource development and quality control of the scutellaria baicalensis stem and leaf.

A composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. A method for preventing, treating, or ameliorating a bone defect or a dental defect comprising administering the composition to a subject in need thereof. A method for producing the composition, comprising: cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and at least one selected from the group consisting of baicalin and bone morphogenetic protein 6 to obtain a cell culture.

The present application relates to the field of cosmetic technology, and discloses an anti-inflammatory soothing cosmetic composition, which comprises the following components in percentage by weight: a barrier repair component: 0.5-4%, an immunomodulatory component: 0.5-3%, a nerve soothing component: 0.3-2.5%, an anti-inflammatory plant complex: 0.3-3%, a moisturizing soothing enhancer: 1-10%, and a balance of auxiliary materials. The above components significantly enhance anti-inflammatory soothing and barrier repair through a five-dimensional synergistic mechanism of 'barrier repair-immune tolerance-nerve desensitization-anti-inflammatory itching-moisturizing stability maintenance'; the introduction of ceramides, rare ginsenosides, plant sterol esters, and free fatty acids synergistically constructs 'bionic liposomes', which are closer to the lipid composition of human stratum corneum, enhance transdermal absorption and stability, and significantly improve repair efficiency; the synergistic effect of dipotassium glycyrrhizinate, tamarix flower extract, spilanthes extract, dinoxanthin, and baicalin suppresses rapid anti-inflammatory itching, strengthens barrier repair, and is suitable for highly sensitive skin.

The invention provides a method for co-producing baicalin, baicalein and wogonin from scutellaria baicalensis extraction waste residues, which comprises the following steps: firstly, extracting the waste residues by adopting an ethanol solution, heating an extracting solution, adjusting the pH value, crystallizing to obtain a crude baicalin product, and refluxing and purifying by using ethanol to obtain the baicalin; the method comprises the following steps: respectively adjusting the pH value of mother liquor, concentrating, combining, extracting by using a water-saturated ethyl acetate-n-butyl alcohol mixed solvent, concentrating an extract phase, diluting by using ethanol, heating, adjusting the pH value, and crystallizing to obtain baicalein; and further adjusting the pH value of the residual filtrate, dealcoholizing, concentrating, cooling and crystallizing, and refining the obtained solid to obtain wogonin. According to the method disclosed by the invention, extraction, fractional precipitation and solvent extraction are combined for use, and the process conditions of each stage are optimized, so that high-purity baicalin, baicalein and wogonin are prepared from the scutellaria baicalensis extraction waste residues, and the utilization value of the waste residues is improved.

The present application relates to the technical field of traditional Chinese medicine analysis, and particularly relates to a quality control method of a traditional Chinese medicine composition. The quality control method comprises the following steps: (1) preparing reference substance solutions: preparing baicalin reference substance solutions and chlorogenic acid reference substance solutions respectively; (2) preparing test sample solutions: preparing a traditional Chinese medicine solution from the traditional Chinese medicine composition, precisely taking 2 mL of the traditional Chinese medicine solution into a 50 mL brown volumetric flask, adding methanol to the calibration mark, and mixing; (3) determining HPLC conditions: optimizing and determining the high performance liquid chromatography (HPLC) conditions of baicalin and chlorogenic acid respectively; and (4) determining methods: precisely taking 20 μL of each of the above reference substance solutions and test sample solutions, and injecting into a HPLC instrument for determination. The method can effectively and quickly control the quality of the traditional Chinese medicine composition.

This invention discloses a method for determining the content of a traditional Chinese medicine compound containing honeysuckle, isatis root, and scutellaria. The method includes the following steps: taking a test solution of the traditional Chinese medicine compound, a first reference solution, and a second reference solution for detection. The chromatographic conditions are as follows: using a chromatographic column packed with octadecyl-bonded silica gel; mobile phase A selected from one or more of acetonitrile, methanol, and tetrahydrofuran; and mobile phase B being an acidic aqueous solution, an alkaline aqueous solution, and / or a buffer salt aqueous solution. The traditional Chinese medicine compound includes honeysuckle, isatis root, scutellaria, indigo leaf, forsythia, platycodon, patchouli, and licorice. The reference standards are baicalin, ammonium glycyrrhizate, honeysuckle saponin B, and dipsacus saponin B. The detection method of this invention is simple, accurate, efficient, stable, precise, reproducible, convenient, and easy to master. It can effectively save energy and reduce analytical costs, while this technology is not disclosed in existing technologies.

This invention discloses a tooth powder with whitening, stain removal, and anti-inflammatory effects, and its preparation method. The tooth powder is a compound of a whitening system, an antibacterial and anti-inflammatory system and a microbiome regulation system, a repair and abrasion system, and a taste-correcting and preservative system. Its core utilizes a specifically formulated biofilm complex enzyme, which can efficiently decompose dental plaque biofilm. Combined with sodium phytate and niacinamide, it achieves gentle whitening and stain removal; with epigallocatechin gallate and baicalin, it achieves targeted antibacterial and anti-inflammatory effects; with probiotic components, it regulates the oral microbiome; and with hydroxyapatite and 45S5 bioactive glass, it repairs tooth enamel. This invention employs customized embedding technology and a graded low-temperature preparation process, significantly improving the storage stability of the active ingredients. The tooth powder of this invention is gentle and non-irritating, does not damage tooth enamel, does not disrupt the oral microecological balance, and has multiple oral care effects with long-lasting and non-rebounding results, making it suitable for large-scale industrial production and long-term use by various population groups.

The invention provides a method for detecting the contents of multiple index components of a coughing oral liquid, which comprises the following steps of: determining the contents of nine key pharmacodynamic index components, namely ephedrine hydrochloride, pseudoephedrine hydrochloride, apiose liquiritin, isoliquiritin, baicalin, huperzin A glycoside, wogonin, baicalein and wogonin; the detection method has the advantages of simplicity and convenience in operation, high stability, high pertinence and high practicability, can be used as a detection and evaluation method for production and internal quality components of the coughing oral liquid, and has a good market application prospect.

The invention relates to a processing technology and processing equipment for improving stability of baicalin in a liquid preparation, and the processing technology comprises the following specific operation steps: optimizing a prescription: controlling the pH value of the preparation to be 5.5-6.0 by adopting a phosphate buffer system, and meanwhile, adding vitamin E as an antioxidant; improving the process: sterilizing by adopting a two-stage filtration sterilization technology; during filling, nitrogen is filled through the filling device to replace oxygen; packaging improvement: selecting an oral liquid medicinal high-density polyethylene bottle containing an opacifying agent as a packaging material; quality control: monitoring the pH value of the preparation in real time in the production process, and setting that the baicalin content is reduced to 90% of the labeled amount as a quality warning line; the pH is accurately controlled within the optimal stable interval of 5.5-6.0, and vitamin E is supplemented for resisting oxidation, so that hydrolysis and oxidation pathways of baicalin are chemically and essentially inhibited.

The invention relates to the technical field of medical dressings, in particular to an anti-inflammatory liquid dressing and a preparation method thereof.The anti-inflammatory liquid dressing is prepared from, by mass, natural anti-inflammatory ingredients including 1-3% of baicalin, 1-2% of honeysuckle extract and 0.5-2% of asiaticoside; a synthetic anti-inflammatory component: 0.1 to 0.5% of chlorhexidine digluconate; film forming materials: 5%-10% of carboxymethyl chitosan and 2%-5% of polyvinylpyrrolidone (PVP); a humectant: 1-3% of hyaluronic acid and 2-5% of glycerin; the pH regulator is 0.5-1% of lactic acid or citric acid and is used for regulating the pH of the system to 4.5-5.5; the traditional Chinese medicine composition has the effects of combining natural components with synthetic components (efficient bacteriostasis), reducing the risk of drug resistance and inhibiting bacterial proliferation.

The invention provides a baicalin carbon dot / silver-based metal organic framework composite material and a drug delivery system. The composite material B-CDs (at) Ag-MOF comprises a silver-based metal organic framework and baicalin carbon dots loaded on the silver-based metal organic framework; the drug delivery system comprises hydrogel and a composite material dispersed in the hydrogel, and the composite material is the B-CDs (at) Ag-MOF. According to the composite material and the drug delivery system provided by the invention, the problems that pure baicalin carbon dots are difficult to release in a controllable manner and the targeting property is insufficient can be solved.

The present application relates to a composition for topical application comprising baicalin and / or at least one derivative thereof or an extract containing baicalin and / or at least one derivative thereof and at least one acrylic polymer, and the use of said composition in the fields of cosmetics and dermatology and in particular for caring for, protecting and / or making up the body or facial skin, or for hair care, preferably for caring for the body or facial skin. Also subject of the present invention is a method for the cosmetic treatment of a keratin material, comprising the application to the keratin material of a composition as defined above, and also the use of said composition in the fields of cosmetics or dermatology and in particular for caring for, protecting and / or making up the body or facial skin, or for hair care, preferably for caring for the body or facial skin.

The invention discloses a sunscreen synergistic supramolecule as well as a preparation method and application thereof, and belongs to the technical field of supramolecules. The sunscreen synergistic supramolecule comprises a sunscreen synergistic substance and a ligand, and the sunscreen synergistic substance is connected with the ligand through an intermolecular acting force; the sunscreen synergistic substance is a ferulic acid substance, a 4-hydroxycinnamic acid substance, a baicalin substance, a chlorogenic acid substance or a rutin substance; the ligand is tranexamic acid, nicotinamide, arbutin, tartaric acid or ascorbic acid. The sunscreen synergistic supramolecule provided by the invention has relatively good biocompatibility and mildness, after the sunscreen synergistic supramolecule is added, the stability and the sunscreen effect of the sunscreen agent are remarkably improved, and the biological activity and the effect of the sunscreen agent are improved.

The invention discloses a construction method of a common goldenrop particle extract fingerprint spectrum and a determination method of index component content, the construction method of the fingerprint spectrum comprises the following steps: taking a common goldenrop particle extract test sample solution, and carrying out ultra-high performance liquid chromatography detection, the ultra-high performance liquid chromatography conditions are as follows: the filler of a chromatographic column is C18, the column temperature is 20-30 DEG C, and the column temperature is 20-30 DEG C; the particle size of a chromatographic column is 1.9 microns, and the column temperature is 25 DEG C; and after an ultra-high performance liquid chromatogram is obtained, calculating the contents of the baicalin, the glycyrrhizic acid, the saikoside b1 and the saikoside b2 according to the peak areas of the baicalin, the ammonium glycyrrhizinate, the saikoside b1 and the saikoside b2. The method is easy and convenient to operate, high in efficiency, accurate and good in reproducibility, the quality of the common goldenrop particle extract can be efficiently and accurately controlled, and the stability and uniformity of the quality of a finished product are guaranteed.

The present disclosure provides a composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. The present disclosure further provides a method for preventing, treating, or ameliorating a bone defect or a dental defect comprising administering the composition of the present disclosure to a subject in need thereof. The present disclosure also provides a method for producing the composition. The method comprises cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and at least one selected from the group consisting of baicalin and bone morphogenetic protein 6 to obtain a cell culture.

The invention provides a construction method and application of a fingerprint spectrum of kidney-tonifying, blood-enriching and fetus-consolidating pills, and belongs to the technical field of medicines. The method comprises the following steps: extracting the kidney-tonifying, blood-enriching and fetus-consolidating pill by adopting a methanol aqueous solution, and taking the kidney-tonifying, blood-enriching and fetus-consolidating pill extracting solution as a test solution; taking a methanol solution of paeoniflorin, ferulic acid, liquiritin, baicalin, quercetin, baicalein and schizandrin as a reference substance solution; respectively carrying out high performance liquid chromatography analysis on the reference substance solution and the test solution, and taking the chromatographic peak of the reference substance solution as the reference to obtain the fingerprint spectrum of the kidney-tonifying, blood-enriching and fetus-consolidating pill. The fingerprint spectrum of the kidney-tonifying, blood-enriching and fetus-consolidating pills is constructed by adopting the high performance liquid chromatography, the quality of the kidney-tonifying, blood-enriching and fetus-consolidating pills can be comprehensively reflected, and the method can be used for quality control of the kidney-tonifying, blood-enriching and fetus-consolidating

The application discloses a process method for simultaneously preparing baicalein, baicalin and baicalin flavones, relates to the technical field of plant extraction, and is characterized in that after baicalin root is crushed and extracted, the extract is concentrated and extracted under different pH values, and after the two extraction phases and the raffinate phases are respectively desolventized, acid precipitated and concentrated, baicalein, baicalin and baicalin flavones are obtained, the utilization rate of raw materials is greatly improved, waste is reduced, the content of baicalin polysaccharide products obtained after the secondary raffinate phases are adsorbed, resolved and concentrated is between 35 wt% and 50 wt%, economic benefits are further improved, waste discharge is small, the environment is friendly, the process and equipment are simple, the cost of raw materials is low, economic benefits are high, and the method is suitable for industrialized production.

The invention discloses a detection method for simultaneously determining the content of multiple components in a lip and tooth stomach clearing pill, and belongs to the technical field of quality control of traditional Chinese medicine compound preparations. According to the detection method, the six components including gentiopicroside, geniposide, berberine hydrochloride, hesperidin, baicalin and chrysophanol can be simultaneously determined through an HPLC wavelength switching method; the method gives consideration to the index components of monarch drugs, ministerial drugs and adjuvant drugs in the lip and tooth stomach clearing pills, has the advantages of simplicity and convenience in operation, high specificity, high accuracy and good repeatability and tolerance, and has positive significance in quality control and comprehensive evaluation of the lip and tooth stomach clearing pills.

The invention provides a candidate medicine for promoting the embryo implantation efficiency of an endometritis type RIF patient, and belongs to the technical field of embryo implantation. In order to solve the problem of how to discover potential intervention drugs aiming at the endometritis type RIF pathological mechanism, a five-step efficient drug screening strategy based on an in-vitro implantation model of the endometritis type RIF is adopted, so that the reliability and function correlation of a screening result are ensured. According to the invention, a candidate drug screened by adopting a five-step method efficient drug screening strategy comprises any one of the following drugs: evocamide, choline, nitrendipine, megestrol acetate, pranoprofen, oxaliplatin, adenine, ensorizole, baicalin and diacerein. Evocamide, choline and nitrendipine in the candidate drugs are three drugs with the best implantation promotion efficiency for patients with endometritis type RIF.

The present application relates to the technical field of biomedical materials, in particular to a non-viral gene carrier and a preparation method and application thereof. The non-viral gene carrier prepared by EDC / NHS cross-linking reaction of baicalin and polyethyleneimine can be used for gene delivery and preparation of a gene therapy drug. The present application further provides a nano-complex composed of the non-viral gene carrier and nucleic acid, which can be used for gene delivery and preparation of a gene therapy drug. The nano-complex can not only effectively deliver target genes into cells, but also synergize miR-34a and baicalin to jointly exert an anti-tumor effect, greatly enhancing the anti-tumor treatment efficacy.

This invention discloses a method for co-loading baicalin and Ca 2+ This paper describes a ROS-responsive in-situ photosensitive gel, its preparation method, and its applications, including a phospholipid membrane-encapsulated composite of baicalin and calcium carbonate nanoparticles, and a ROS-responsive gel matrix. This photosensitive gel exhibits high adhesion, ROS-responsive drug release, in-situ photosensitized curing, and the ability to release baicalin and calcium carbonate nanoparticles. 2+ Its advantages, such as synergistic therapy, have significantly improved the treatment effect of periodontitis, providing new drug carriers and treatment options for the clinical treatment of periodontitis.

The present application is suitable for Scutellarein detection technical field, especially relates to a method for detecting the content of Scutellarein in traditional Chinese medicinal materials, comprising the following steps: step S1: selecting a predetermined amount of the to-be-tested traditional Chinese medicinal material, crushing it, mixing it with a predetermined amount of quartz sand, and then using a first pre-set concentration of ethanol solution for first extraction to obtain a preliminary extraction solution; step S2: performing solid-liquid separation on the preliminary extraction solution to separate out the ethanol extraction solution and retain the dregs; step S3: weighing a certain amount of the dregs, using a second pre-set concentration of ethanol solution for second extraction, and taking a proper amount of the second extraction solution as a sample solution. The present application realizes efficient and accurate detection of Scutellarein by optimizing the extraction conditions and the liquid chromatography detection steps. First, 70% ethanol solution is used for first extraction, which effectively dissolves Scutellarein in the traditional Chinese medicinal material, reduces impurity interference, and improves the purity of the preliminary extraction solution.

The invention relates to the technical field of biological medicine, and particularly discloses a traditional Chinese medicine compound based on iPSC exosomes and a preparation method and application of the traditional Chinese medicine compound. The invention discloses a traditional Chinese medicine compound based on an iPSC exosome. The traditional Chinese medicine compound is prepared by loading a fat-soluble component and a hydrophilic component on the iPSC exosome, the diameter of the iPSC exosome is 30-150 nm, and the total drug loading capacity of the iPSC exosome is 40-60 [mu] g / mg protein; the fat-soluble component is selected from pachymic acid and curcumin; and the hydrophilic component is selected from ginsenoside Rg1 and baicalin. The traditional Chinese medicine compound provided by the invention realizes synchronous delivery of traditional Chinese medicine micromolecules of fat-soluble components and hydrophilic components on the basis of the iPSC exosome; the problem that the exosome is single in drug loading variety is solved, the drug loading rate and the encapsulation rate are improved, and the application prospect in depression treatment drugs is wide.