85 results about "Baicalin" patented technology

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention is applicable to the technical field of biomedical materials, and provides an anti-inflammatory hemostatic composite gel microsphere and a preparation method and application thereof, and the preparation method comprises the following steps: mixing sodium alginate and baicalin, dissolving in deionized water to obtain a mixed solution, spraying the mixed solution into a calcium chloride solution by utilizing electrospinning and electrospraying, and carrying out electrostatic spinning and electrospraying to obtain the anti-inflammatory hemostatic composite gel microsphere. Gel microspheres are formed through ionic crosslinking; washing the gel microspheres with a calcium chloride solution, and soaking the gel microspheres in a chitosan acetic acid solution to obtain chitosan-encapsulated gel microspheres; placing the gel microspheres in a copper sulfate solution, and performing low-temperature calcium-copper ion exchange to obtain baicalin / copper alginate composite gel microspheres; and filtering, washing and freeze-drying the composite gel microspheres. The electrospray technology is combined with ionic crosslinking, the size and morphology of the microspheres are accurately controlled, the antibacterial effect on escherichia coli and staphylococcus aureus is remarkable, the in-vitro blood coagulation time is shortened by 30%, the cytotoxicity is low, and good biocompatibility is achieved.

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.

A composite membrane comprises a membrane matrix formed by the stable cross-linking of silk fibroin with β-sheets, and baicalin uniformly dispersed between the segments of the silk fibroin molecular chain, wherein the mass ratio of silk fibroin to baicalin is 100:3-4. The preparation method includes the following steps: 1) taking silkworm cocoons, boiling them several times with sodium carbonate solution, washing them, and drying them to 60°C; 2) dissolving them in a ternary solution, centrifuging and filtering to obtain a clear silk fibroin solution, and drying it to obtain silk fibroin; 3) preparing a silk fibroin solution with a concentration of 1-30 mg / ml, and adjusting the pH to 7.4; 4) adding baicalin to the silk fibroin solution, forming a film, drying it, and annealing it to obtain the composite membrane. The composite membrane of this invention has superior biocompatibility, hemostatic properties, and controllable biodegradability, and can promote M2 polarization of macrophages, shorten the inflammatory period, and effectively promote skin wound healing.

This invention relates to diselenylene-bridged mesoporous silica nanoparticles loaded with baicalin and their applications. The invention constructs a ROS-responsive, microglia-inspired Ba@Se-MSN&BV2 nanoplatform targeting the secondary phase of spinal cord injury. The BV2 cell membrane-mediated enrichment at the injury site, combined with the diselenylene-triggered, on-demand release of baicalin, enables targeted intervention in a highly oxidative and pro-inflammatory microenvironment. In vitro and in vivo studies show that Ba@Se-MSN&BV2 can alleviate oxidative stress and mitochondrial dysfunction, inhibit apoptosis, promote axonal and neuronal survival, and improve motor circuit function. This invention provides a new therapeutic target and research direction for neuroinflammatory injuries driven by redox homeostasis disruption, with significant clinical application prospects and social value.

The application discloses a baicalin ternary co-amorphous drug and a preparation method and application thereof, and the amorphous substance can effectively improve the solubility and dissolution of puerarin and baicalin. The application mixes metformin hydrochloride, puerarin and baicalin according to a molar ratio of 1:1:1, and obtains the baicalin ternary co-amorphous drug through a ball milling method or a solvent-assisted milling method, the preparation method is green and efficient, the co-amorphous substance has high light stability and thermal stability, the solubility is increased by 1.7 times compared with that of a puerarin raw drug crystal, the solubility is increased by 46.8 times compared with that of a baicalin raw drug crystal, and the solubility is reduced by 14.8 times compared with that of a metformin hydrochloride raw drug crystal. The baicalin ternary co-amorphous drug has certain application prospects in liver protection, blood sugar reduction, treatment of damp-heat type colitis and cervical cancer.

The application discloses a preparation method of a hydrocolloid dressing for oral cavity, and relates to the technical field of medical supplies. Baicalin extract and a polyvinyl pyrrolidone solution are mixed to obtain a baicalin extract solution; chitosan fibers, hydroxymethyl cellulose and the baicalin extract solution are mixed to obtain a mixed solution; vacuum degassing: the prepared mixed solution is vacuumized, pressure is maintained, and primary degassing is performed; ultrasonic degassing: the mixed solution after primary degassing is subjected to ultrasonic degassing; static degassing: the solution after ultrasonic degassing is sealed by using a preservative film, and is subjected to secondary degassing at room temperature; a PU film is fixed in a film laying frame, the degassed mixed solution is poured into the film laying frame, and the film laying frame is placed into an air-blowing drying box to solidify and form a protective layer, so that the hydrocolloid dressing is obtained. The hydrocolloid dressing prepared by the method has good adhesion, can be used on a wound for a long time, and can effectively promote the repair of damaged cells and wounds, so that the healing of the wound in the oral cavity is promoted.

This invention belongs to the field of baicalin crystallization technology, and relates to a leaf-shaped baicalin crystal, its preparation method, and its application. The crystal has a leaf-like microstructure with a length ranging from 1 μm to 17 μm; the bulk density of the crystal is 0.1-0.2 g / mL, and the compactness is 0.2-0.4 g / mL. The leaf-shaped baicalin crystals provided by this invention are easy to compress into tablets and have a high surface area / volume ratio, which is beneficial for its adsorption and dissolution in vivo. The preparation process is simple to operate and can directionally prepare leaf-shaped baicalin crystals. The purity of the obtained leaf-shaped baicalin crystals can reach 93% or higher, significantly improving the chemical purity and forming a unique low bulk density physical property.

To provide a skin cosmetic composition that exhibits excellent anti-inflammatory effects on the skin by increasing the production of IL-1ra, which prevents inflammatory signaling to cells. [Solution] (A) Curcumin and, (B) Contains baicalin, The skin cosmetic composition is characterized in that the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less.

The application aims to provide a preparation method and application of a photocrosslinking zinc-doped baicalin carbon dot-based hydrogel, and belongs to the field of biomedical technology.The baicalin and zinc acetate solution are used as precursors to prepare zinc-doped CDs at 180 DEG C.Meanwhile, a methacrylated gelatin precursor solution is prepared, the carbon dots are added in a certain proportion, and the zinc-doped baicalin carbon dot-based hydrogel is obtained under ultraviolet crosslinking.The carbon dot hydrogel combines the advantages of carbon dots and hydrogels, and has a certain application prospect in wound infection treatment.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a pharmaceutical composition for recurrent urinary tract infection and a preparation method thereof. According to the invention, a compound extract for warming yang, promoting diuresis and activating blood and baicalin are synergistically compounded in an ion composite network formed by sodium alginate and chitosan, and are subjected to shear dispersion or homogenization treatment to form ion composite nanoparticles, and then the ion composite nanoparticles are subjected to calcium chloride cross-linking solidification and chitosan coating to prepare a multi-layer synergistic carrier design of the pellet; the dispersion uniformity, the forming strength, the pH response release and the storage stability of the ionic composite nanoparticles under the condition of high drug loading capacity are realized, and the core contradiction that the mechanical strength, the in-vivo swelling response release and the low-water-content storage and transportation stability are difficult to consider at the same time in the existing calcium alginate carrier system is solved; the method has wide clinical application value in comprehensive prevention and treatment of recurrent urinary tract infection.

The invention relates to a fingerprint construction method of a pharmaceutical composition for preventing and treating throat diseases, which comprises the following steps: weighing the pharmaceutical composition, adding the pharmaceutical composition into a 50-100% methanol solution, performing ultrasonic or reflux extraction, complementing the reduced weight, and filtering to obtain a test solution, the pharmaceutical composition being composed of scutellaria baicalensis, radix scrophulariae, platycodon grandiflorum, fructus chebulae, mint and liquorice; weighing baicalin and wogonoside, and adding the baicalin and wogonoside into a methanol solution to obtain a reference substance solution; and respectively injecting the test solution and the reference solution into a high performance liquid chromatograph, performing chromatographic analysis, recording corresponding chromatograms, and constructing the fingerprint spectrum of the pharmaceutical composition for preventing and treating throat diseases. The fingerprint spectrum constructed by the invention has characteristics, reproducibility and operability, and can be used for quality control of the pharmaceutical composition for preventing and treating throat diseases.

The invention relates to the technical field of medicines, in particular to a preparation method and application of a baicalin self-microemulsifying preparation taking ginsenoside as an effective auxiliary. The baicalin self-microemulsifying preparation is prepared by innovatively adding the natural medicine ginsenoside with various known pharmacological activities as one of the effective auxiliary agents, so that the problem of low solubility of the baicalin can be improved, and the oral availability of the baicalin is improved by 4.38 times; and compounding of two natural medicine components with definite biological activity on preparations is realized, and a basis is provided for clinical application of baicalin as a medicine.

The invention discloses a construction method and application of a scutellaria baicalensis stem and leaf fingerprint spectrum, and belongs to the technical field of medicine quality control. The method comprises the following steps: preparing standard substance solutions of scutellarin, baicalin, taxifolin and isoschaftoside; preparing a scutellaria baicalensis stem and leaf sample solution; detection is carried out under specific conditions through high performance liquid chromatography, a standard fingerprint spectrum of the stems and leaves of scutellaria baicalensis is made by taking a standard chromatographic peak as a reference, and the relative standard deviation of the relative retention time does not exceed + / -20%. The method disclosed by the invention is high in precision, good in stability and excellent in repeatability, effective separation of four flavonoid components can be realized within 35 minutes, and the quality characteristics of stems and leaves of scutellaria baicalensis are comprehensively reflected. The invention further provides application of the fingerprint spectrum in quality analysis of the scutellaria baicalensis stem and leaf medicinal material and the extract thereof, and reliable technical support is provided for resource development and quality control of the scutellaria baicalensis stem and leaf.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for simultaneously determining the contents of various components in Shuanling antidiarrheal granules based on a UPLC-QQQ-MS / MS. The contents of 18 components in the Shuanling antidiarrheal granules are simultaneously determined by using an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. The 18 components comprise adenosine, gallic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, liquiritin, ellagic acid, kaempferitrin, narirutin, hesperidin, baicalin, oroxylin A-7-O-beta-D-glucuronide, wogonin, baicalein, wogonin, pachymic acid B and pachymic acid A. The invention further discloses a preparation method of the pharmaceutical composition. Through the UPLC-QTRAP-MS / MS combined technology, the technical prejudice that single component depends on in quality control of the traditional Chinese medicine compound preparation is broken through, the key problems that multiple components in a complex matrix are difficult to separate, low-content components are difficult to detect and the like are solved, efficient, accurate and synchronous determination of 18 components is achieved, and the method is suitable for large-scale popularization and application. A new reference path is opened up for modernized quality control of the traditional Chinese medicine compound preparation.

A composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. A method for preventing, treating, or ameliorating a bone defect or a dental defect comprising administering the composition to a subject in need thereof. A method for producing the composition, comprising: cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and at least one selected from the group consisting of baicalin and bone morphogenetic protein 6 to obtain a cell culture.

The invention discloses a nano drug-loaded nasal spray composition for treating nasosinusitis. The nano drug-loaded nasal spray composition is prepared from the following raw materials: nano silver, PVP (Polyvinyl Pyrrolidone), baicalin, flos magnoliae volatile oil, chitosan, PLGA (Poly (Lactic-co-Glycolic Acid), sodium hyaluronate, a citrate buffer solution and the balance of sterile normal saline. The invention also discloses a preparation method of the nano drug-loaded nasal spray composition for treating nasosinusitis, the preparation method comprises the following steps: firstly preparing PVP modified nano silver suspension, then preparing baicalin nanoparticles and magnolia flower volatile oil nanoparticles by adopting an emulsification-solvent evaporation method, and PVP is used as a stabilizer of nano silver to ensure the long-term dispersion stability of nano silver, so that the stability of the nano silver is ensured, and the stability of the nano silver is ensured. Finally, all the components are mixed in a sterile operation table, the pH is adjusted, filtration sterilization is conducted through a 0.22-micron sterile filter membrane, terminal sterilization is conducted through gamma-ray irradiation after split charging is conducted, and the final product can be prepared into quantitative spray or sterile nose drops to meet different clinical requirements.

The present application relates to the field of cosmetic technology, and discloses an anti-inflammatory soothing cosmetic composition, which comprises the following components in percentage by weight: a barrier repair component: 0.5-4%, an immunomodulatory component: 0.5-3%, a nerve soothing component: 0.3-2.5%, an anti-inflammatory plant complex: 0.3-3%, a moisturizing soothing enhancer: 1-10%, and a balance of auxiliary materials. The above components significantly enhance anti-inflammatory soothing and barrier repair through a five-dimensional synergistic mechanism of 'barrier repair-immune tolerance-nerve desensitization-anti-inflammatory itching-moisturizing stability maintenance'; the introduction of ceramides, rare ginsenosides, plant sterol esters, and free fatty acids synergistically constructs 'bionic liposomes', which are closer to the lipid composition of human stratum corneum, enhance transdermal absorption and stability, and significantly improve repair efficiency; the synergistic effect of dipotassium glycyrrhizinate, tamarix flower extract, spilanthes extract, dinoxanthin, and baicalin suppresses rapid anti-inflammatory itching, strengthens barrier repair, and is suitable for highly sensitive skin.

The invention discloses an indwelling scalp care pomade composition and a preparation method thereof, and relates to the technical field of daily chemical products, the indwelling scalp care pomade composition comprises the following components by mass: 7-26% of a wax / fat phase, and 0.5-3% of an emulsification system; 0.5% to 4% of a touch powder; 0.05% to 0.8% of a cationic conditioner; the compound comprises at least three mass markers selected from the group consisting of cnidium lactone, glycyrrhizic acid or a mono-ammonium salt thereof, total flavonoids of rhizoma smilacis glabrae, berberine, baicalin, salvianolic acid and indirubin, and through the cooperation of the added herbal components and the taste control module in the process, the stability of the active components is maintained, and the taste of the active components is improved. The overall smell characteristic of the product is effectively controlled, and finally the matte pomade product with good performance in the aspects of shaping durability, visual attractiveness, scalp friendliness and use comfort is obtained.

The invention relates to the technical field of medicine preparation, and discloses a preparation method of radix asparagi and radix asparagi decoction granules with high baicalin extraction rate, which comprises the following steps: mixing raw medicinal materials, extractant microspheres and water, decocting under the condition of pH lower than the isoelectric point of carboxymethyl chitosan, magnetically separating the extractant microspheres adsorbed with baicalin, and filtering to obtain dregs and filtrate; the extractant microsphere comprises a Fe3O4 core, a carboxymethyl chitosan layer and a poly (N-isopropylacrylamide) layer, the Fe3O4 core is sequentially coated with the carboxymethyl chitosan layer and the poly (N-isopropylacrylamide) layer, the isoelectric point of carboxymethyl chitosan is 6.5-7.0, and the poly (N-isopropylacrylamide) layer takes baicalin as a template agent and is formed at the temperature not lower than 35 DEG C; and mixing the extractant microspheres adsorbed with baicalin with the filtrate, carrying out desorption and magnetic separation under the conditions that the temperature is 15-25 DEG C and the pH value is higher than the isoelectric point of carboxymethyl chitosan, and preparing the obtained extracting solution into the Eupatorium japonicum and Danhuang decoction granules. By adopting the preparation method disclosed by the invention, the extraction effect of the baicalin can be improved, so that the content of the baicalin in the radix asparagi decoction granules is increased.

The invention provides a method for co-producing baicalin, baicalein and wogonin from scutellaria baicalensis extraction waste residues, which comprises the following steps: firstly, extracting the waste residues by adopting an ethanol solution, heating an extracting solution, adjusting the pH value, crystallizing to obtain a crude baicalin product, and refluxing and purifying by using ethanol to obtain the baicalin; the method comprises the following steps: respectively adjusting the pH value of mother liquor, concentrating, combining, extracting by using a water-saturated ethyl acetate-n-butyl alcohol mixed solvent, concentrating an extract phase, diluting by using ethanol, heating, adjusting the pH value, and crystallizing to obtain baicalein; and further adjusting the pH value of the residual filtrate, dealcoholizing, concentrating, cooling and crystallizing, and refining the obtained solid to obtain wogonin. According to the method disclosed by the invention, extraction, fractional precipitation and solvent extraction are combined for use, and the process conditions of each stage are optimized, so that high-purity baicalin, baicalein and wogonin are prepared from the scutellaria baicalensis extraction waste residues, and the utilization value of the waste residues is improved.

The present application relates to the technical field of traditional Chinese medicine analysis, and particularly relates to a quality control method of a traditional Chinese medicine composition. The quality control method comprises the following steps: (1) preparing reference substance solutions: preparing baicalin reference substance solutions and chlorogenic acid reference substance solutions respectively; (2) preparing test sample solutions: preparing a traditional Chinese medicine solution from the traditional Chinese medicine composition, precisely taking 2 mL of the traditional Chinese medicine solution into a 50 mL brown volumetric flask, adding methanol to the calibration mark, and mixing; (3) determining HPLC conditions: optimizing and determining the high performance liquid chromatography (HPLC) conditions of baicalin and chlorogenic acid respectively; and (4) determining methods: precisely taking 20 μL of each of the above reference substance solutions and test sample solutions, and injecting into a HPLC instrument for determination. The method can effectively and quickly control the quality of the traditional Chinese medicine composition.

This invention discloses a method for determining the content of a traditional Chinese medicine compound containing honeysuckle, isatis root, and scutellaria. The method includes the following steps: taking a test solution of the traditional Chinese medicine compound, a first reference solution, and a second reference solution for detection. The chromatographic conditions are as follows: using a chromatographic column packed with octadecyl-bonded silica gel; mobile phase A selected from one or more of acetonitrile, methanol, and tetrahydrofuran; and mobile phase B being an acidic aqueous solution, an alkaline aqueous solution, and / or a buffer salt aqueous solution. The traditional Chinese medicine compound includes honeysuckle, isatis root, scutellaria, indigo leaf, forsythia, platycodon, patchouli, and licorice. The reference standards are baicalin, ammonium glycyrrhizate, honeysuckle saponin B, and dipsacus saponin B. The detection method of this invention is simple, accurate, efficient, stable, precise, reproducible, convenient, and easy to master. It can effectively save energy and reduce analytical costs, while this technology is not disclosed in existing technologies.

According to the screening method of the natural antibiotic-free medicine for preventing and treating methicillin-resistant staphylococcus aureus, the provided screening method can screen out the optimal medicine composition and proportion, and the screened medicine serves as an alternative scheme of antibiotic treatment; and a medicine screening and research and development foundation is laid for treating infection of methicillin-resistant staphylococcus aureus. The method for rapidly screening the natural drug monomer composition aiming at the methicillin-resistant staphylococcus aureus is provided by comprehensively applying a minimum inhibitory concentration experiment and an orthogonal method, and the method is low in cost, less in time consumption and simple to operate. The method provided by the invention verifies that the three natural drug monomers of baicalin, emodin and caffeic acid have a synergistic effect, and meanwhile, when the three drug monomers of baicalin, emodin and caffeic acid are screened according to the method provided by the invention and are combined according to the mass ratio of 2: 1: 4, the antibacterial effect on methicillin-resistant staphylococcus aureus is the best.

The invention relates to the technical field of drug detection, in particular to a fingerprint construction and multi-index component content determination method based on high performance liquid chromatography for a scutellaria baicalensis, manchurian lilac root and safflower cough-relieving preparation, which comprises the following steps: (1) preparation of a test solution: taking a sample of the scutellaria baicalensis, manchurian lilac root and safflower cough-relieving preparation, adding a methanol solution, performing ultrasonic treatment, and filtering to obtain the test solution; (2) preparation of a reference substance solution: dissolving a baicalin and / or syringin reference substance in a methanol solution to obtain the reference substance solution; (3) high performance liquid chromatography detection: injecting the test solution and the reference solution into a high performance liquid chromatograph, wherein the chromatographic conditions are as follows: a chromatographic column is an octadecylsilane chemically bonded silica packed column; the mobile phase A is methanol; the invention effectively solves the problem that a quantitative or qualitative detection method for the scutellaria baicalensis, manchurian lilac root and safflower cough-relieving mixture is lacked in the prior art, so that a method for constructing the fingerprint spectrum of the scutellaria baicalensis, manchurian lilac root and safflower cough-relieving preparation and determining the content of multiple index components based on high performance liquid chromatography is provided.

This invention discloses a tooth powder with whitening, stain removal, and anti-inflammatory effects, and its preparation method. The tooth powder is a compound of a whitening system, an antibacterial and anti-inflammatory system and a microbiome regulation system, a repair and abrasion system, and a taste-correcting and preservative system. Its core utilizes a specifically formulated biofilm complex enzyme, which can efficiently decompose dental plaque biofilm. Combined with sodium phytate and niacinamide, it achieves gentle whitening and stain removal; with epigallocatechin gallate and baicalin, it achieves targeted antibacterial and anti-inflammatory effects; with probiotic components, it regulates the oral microbiome; and with hydroxyapatite and 45S5 bioactive glass, it repairs tooth enamel. This invention employs customized embedding technology and a graded low-temperature preparation process, significantly improving the storage stability of the active ingredients. The tooth powder of this invention is gentle and non-irritating, does not damage tooth enamel, does not disrupt the oral microecological balance, and has multiple oral care effects with long-lasting and non-rebounding results, making it suitable for large-scale industrial production and long-term use by various population groups.

The invention provides a method for detecting the contents of multiple index components of a coughing oral liquid, which comprises the following steps of: determining the contents of nine key pharmacodynamic index components, namely ephedrine hydrochloride, pseudoephedrine hydrochloride, apiose liquiritin, isoliquiritin, baicalin, huperzin A glycoside, wogonin, baicalein and wogonin; the detection method has the advantages of simplicity and convenience in operation, high stability, high pertinence and high practicability, can be used as a detection and evaluation method for production and internal quality components of the coughing oral liquid, and has a good market application prospect.

The invention relates to a processing technology and processing equipment for improving stability of baicalin in a liquid preparation, and the processing technology comprises the following specific operation steps: optimizing a prescription: controlling the pH value of the preparation to be 5.5-6.0 by adopting a phosphate buffer system, and meanwhile, adding vitamin E as an antioxidant; improving the process: sterilizing by adopting a two-stage filtration sterilization technology; during filling, nitrogen is filled through the filling device to replace oxygen; packaging improvement: selecting an oral liquid medicinal high-density polyethylene bottle containing an opacifying agent as a packaging material; quality control: monitoring the pH value of the preparation in real time in the production process, and setting that the baicalin content is reduced to 90% of the labeled amount as a quality warning line; the pH is accurately controlled within the optimal stable interval of 5.5-6.0, and vitamin E is supplemented for resisting oxidation, so that hydrolysis and oxidation pathways of baicalin are chemically and essentially inhibited.

The present application relates to a kind of preservative solution for prolonging the in vitro storage period of platelet and its preparation method, containing baicalin 4.50~6.00g, baicalein 3.00~3.40g, sodium citrate 1.50~2.00g, citric acid 0.20~0.50g, glucose 7.90~8.50g per liter of preservative solution, and the remaining component is distilled water.The preservative solution of the present application adds a certain proportion of baicalin and baicalein, and the composition has a synergistic effect on inhibiting platelet activation, protection and inhibition of platelet aggregation, can prolong the in vitro platelet normal temperature storage time, and the normal temperature storage time can reach 16d.

This invention discloses a soothing and oil-controlling composition, its preparation method, and its application. The aim is to provide a composition that effectively increases bioavailability, promotes skin penetration of baicalin, reduces the dosage of baicalin, and possesses soothing and oil-controlling properties. It also provides a method for preparing the extract of the composition that improves extraction rate, promotes mutual solubility, is easily implemented on a production line, facilitates large-scale production, and produces a high-clarity and highly stable extract. The technical solution includes 150-200 parts of Scutellaria baicalensis and 40-80 parts of Corydalis yanhusuo; it belongs to the field of cosmetic technology.