913 results about "Baicalin" patented technology

This invention relates to new safe natural drug, which is prevention of cancer and control of cancer cells. Specifically, this invention provides methods for producing of Berberine and Baicalin.Also, the present invention proved a new radioimmunoassay (RIA) method for precise determination of Berberine and Baicalin. The RIA is an efficient analytical method for large clinical programs including double blind analysis (DBA), and good clinical practice (GCP).

The invention discloses a novel preparation method for a pinellia stomach-harmonizing Chinese patent medicine. The Chinese patent medicine is prepared by performing microwave heating and ultrasonic mixing on ginger processed pinellia, Baikal skullcap root, honey-fried licorice root, jujube, dried ginger, coptis and pilose asiabell root to extract active ingredients in the medicinal materials. The method radically overcomes the defect of low extraction rate of active ingredients extracted by common methods such as water extraction and ethanol extraction in most conventional Chinese medicines. The method avoids discomfort caused by decocting the Chinese medicaments, and can greatly extract the active ingredients of the medicaments such as baicalin, saponin and various trace elements particularly by organically combining the processes of microwave and ultrasonic mixing extraction and the like. Moreover, the extraction purity is high, the loss of the active ingredients is low, and the problem of preventing the active ingredients of the extracts from being volatilized in the industry is solved. The prepared medicine has a remarkable treatment effect, has the effects of soothing liver and regulating qi, harmonizing stomach and reducing heat, tonifying stomach and nourishing yin, harmonizing stomach and dispersing blood stasis, has good compliance, and is suitable for various stomach disease patients to administrate.

The invention relates to a plant active component composition with slow anti-allergic action. The plant active component composition is mainly prepared from natural plant active components: 0.1-5wt% of glycyrrhetinic acid, 0.05-1wt% of apigenin, 0.05-1% of table gallic catechin gallic acid ester, 0.1-3wt% of asiaticoside, 0.1-5wt% of baicalin and 0.1-10wt% of fucus serratus extract. The composition is used for preparing cosmetics or personal care products with a plurality of effects of resisting skin allergy, diminishing inflammation, relieving itching, resisting oxidation, moisturizing and the like. The composition is safe and free of toxic and side effects, and can be compounded with a plurality of components, sensitive skin and dry skin are effectively improved, and the barrier function of the skin is reinforced.

This is a kind of baicalin total flavones glucoside distillation, baicalin monomer flavones glucoside and its preparation method and application, belonging to the Chinese native medicine drugs manufacturing technology field. The invention obtains the baical in total flavones glucoside distillation mainly containing biacalein, or baical in flavones glucoside monomer compound mainly containing biacalein or wogonoside or oroxylin; comminute baixcal, add water, have alcoholysis reaction at 41 -46 Deg. C, the baialinase and baicalin flavones glucoside naturally existing in baixcal directly have alcoholysis reaction without distillation and separation. The pharmacy preparation includes various pharmacy preparations comprised of officinal auxiliary materials with baicalin total flavones glucoside distillation or monomer flavones glucoside as pharmacy active components, and are used to prepare drugs for curing liver diseases and AIDS. The reaction condition of the invention is mild, and it has high distilling rate, good product quality, low energy waste simple craft, no pollution and low production cost.

The invention discloses a baicalin thermosensitive gelatin and a preparation method and use thereof. The baicalin thermosensitive gelatin is prepared by the following steps: (1) taking the following components in percentage by weight: 0.6 to 15 percent of baicalin, 10 to 24 percent of poloxamer 407, 1 to 10 percent of poloxamer 188, 55.8 to 81.17 percent of solvent, 0 to 5 percent of viscosity modifier, and 0 to 0.2 percent of preservative; and (2) dissolving the baicalin and the preservative into the solvent, slowly adding the poloxamer 407 and the poloxamer 188 with stirring, mixing uniformly, adding the viscosity modifier, mixing uniformly, and placing the mixture into freely flowable semitransparent solution to prepare the baicalin thermosensitive gelatin. The baicalin thermosensitive gelatin is flowable liquid at normal temperature, which generates reversible phase change if affected by the body temperature after contacting with a mucous membrane or body fluid. Therefore, the medicament is tightly attached to the mucosal tissue, which is hard to leak. After the phase change is generated in the body fluid, the release rate of the medicament can be controlled.

The invention relates to the technical field of preparation of extracting agents and deep-eutectic solvents, and relates to application of an extracting agent and a deep-eutectic solvent in determining of effective ingredients in traditional Chinese medicine, in particular to application in determining of flavonoid ingredient in radix scutellariae, and application of an extracting agent and a deep-eutectic solvent in determining of effective ingredients of baicalin, baicalein, wogonoside, wogonin and scutellarin in radix scutellariae. The application is characterized in that the radix scutellariae is used as the raw material, the deep-eutectic solvent, especially choline deep-eutectic solvent, is used as the extracting agent, the water is used as a thinner for reducing the system viscosity, and the flavonoid compound is forcibly extracted under the ultrasonic condition. An extracting method has the advantages that the extracting efficiency of the flavonoid ingredient is higher, the extracting conditions are moderate, and the operation is simple and convenient. The extracting agent has the characteristics of no burning explosion and volatizing, small loss, low energy consumption andthe like. The extracting method is also suitable for extracting the flavonoid-containing traditional Chinese medicines, such as radix astragali seu hedysari, liquorice root, radix puerariae and radixsophorae flavescentis.

The invention provides a facial make-up with excellent effect on moisturizing, whitening and nourishing and small irritation to skin. The facial make-up consists of make-up substrate and make-up active substances, wherein the make-up active substances comprise glycolic acid, kojic acid, arbutin, aloin, baicalin, paeoniflorin, glycyrrhizic acid, squalane, hyaluronic acid and chitin to be prepared into toner, facial cream, facial cleanser, facial mask, gel and external soft capsule preparations.

The process for extracting baicalin from scutellaia root includes the following steps: breaking scutellaria root into small blocks, according to the weight of scutelliaria root adding 3-10 times boiling water, decocting for 3 times, every time for 1-3 hr. straining, combining colatures, standing still for removing impurities, using hydrochloric acid to regulate pH value of colature to 1-2, heat-insulating for 30-60 min. at 70-80 deg.C, separating out baicalin precipitate, using acidic water or water to wash baicalin precipitate for several times, heat-insulating and standing still for above 12 hr. at 70-80 deg.C, filtering and precipitating, then drying to obtain baicalin crude product. The baicalin crude product content is above 80%, and the extraction rate of baicalin is above 80%.

The invention discloses a sun cream made of Chinese medicinal composition and a method for producing the same. The sun cream is finely made of the essential component consisting of rutoside and baicalin, and added cream substrate. The effective components of the product can absorb ultraviolet of UVA UVB wavebands, consequently, effects of skin protecting and sunburn preventing are generated.

The invention discloses a new traditional Chinese medicine composite for treating cough disease and a preparation method thereof. In the invention, the traditional Chinese medicine composite is mainly prepared from the following pharmaceutical products: baicalin, perillaseed, hogfennel root, honeysuckle, radix sileris, notopterygium root, Schizonepeta, radix bupleuri, mint, dandelion, radix rehmanniae, moutan bark, radix paeoniae alba, angelica sinensis, rheum officinale, mangnolia officinalis, lily, tangerine peel, medicated leaven, fruit of immature citron, semen raphani, Platycodon grandiflorum, bulbus fritillariae cirrhosae, almond, loquat leaf, Acorus gramineus, borneol, radix ophiopogonis, radix trichosanthis, fructus forsythiae and chrysanthemum and can be prepared into any one of oral preparations in common use according to the general traditional Chinese medicine preparation method. The invention has the following remarkable improvements: cough, expectoration, shortness of breath, asthma, chest stuffiness and labored breathing all are disappeared, the symptoms, such as fever, palpitation, circulation of vital energy in the wrong direction and the like, are released, the clinic curative effect is definite, and the curative effect is remarkable and fast. Because the traditional Chinese medicine composite is basically composited from medicines in which drugs and foods have the same source stated by National Formulary, the composite has the advantages of low cost, no toxic or side effect basically and the like.

The invention relates to a high-yield technology for producing baicalin from a raw material, namely, baical skullcap roots, with a biological enzyme fermentation technology. According to the technical scheme, the technology comprises steps as follows: reflux extraction of the baicalin is performed on a raw material with boiling water containing a solubilizing agent firstly, a complex enzyme is added to an extract for hydrolysis, after refined filtration, a filtrate is heated to the temperature ranging from 70 DEG C to 100 DEG C, the baicalin precipitates by the aid of hydrochloric acid, is washed with water for acid removal and then is dried, the prepared baicalin content exceeds 85%, the baicalin conforms to national standard requirements, and indexes such as the solubility, the color and the like of the baicalin reach the high-quality level. With the adoption of the technology, the production process of the baicalin is simplified, the yield is increased, the production efficiency is improved, the cost is low, and the technology is suitable for large-scale production.

The invention discloses a mycotoxin toxin adsorbent of a livestock and poultry feed and a preparation process. The mycotoxin toxin adsorbent is prepared from modified montmorillonite, yeast extract, lactobacillus acidophilus, lactobacillus amylovorus, sialic acid lactobacillus, streptococcus thermophilus, bacillus subtilis, honeysuckle extract, camellia oil extract, glycyrrhizic acid, echinacea extract, eugenol, cinnamic aldehyde, baicalin, vitamin C, vitamin E and zinc methionine. The mycotoxin toxin adsorbent provided by the invention can realize efficient adsorption on a plurality of types of common mycotoxin and the conversion rate of the feed is improved; meanwhile, the balance of intestinal flora of livestock and poultry can be promoted, and the added zinc methionine in the formula also has the effect of protecting livers; and the selected raw materials are natural and pollution-free and have a very good application value in feed and cultivation industries.

Belonging to the technical field of disinfection, the invention discloses a skin disinfection gel to solve the disadvantages of existing disinfection technologies, especially preoperative disinfection technologies. The skin disinfection gel is composed of the following active components by mass: 1.5%-6% of chitosan, 1.5-10% of chitosan oligosaccharide, 2%-8% of baicalin, 0.5%-2% of chlorhexidine, 0.5%-1.5% of sodium alginate, 2%-5% of agarose, and 1.5%-5% of a mint extract. And the disinfection effect is good. The disinfection gel disclosed in the invention can be used for hand disinfection or skin disinfection in sanitary disinfection or preoperative disinfection, and with excellent disinfection effects and lasting function, it has very good application prospects and economic benefits.

The invention relates to a fresh-cut processing method of a baical skullcap root slice. The invention is characterized in that the picked or dug fresh baical skullcap root is directly cut into slices after the impurities such as soil, etc. are removed, the baical skullcap root is cut into transverse section slices with the thickness of 2 to 3 mm, and are heated for 20 minutes under 60 DEG C, and are then dried naturally or dried at low temperature. After the raking, if the baical skullcap root is not processed timely, the oxidation greening at the wounds can be caused. The fresh-cut processing technique of the invention realizes the purpose of enzyme elimination through directly cutting the fresh baical skullcap root into slices, and steaming for a short time (20 minutes), and thereby the production efficiency is improved by 90 times, the energy consumption is greatly saved, the production cost is lowered, and the retaining of the effective component (baicalin) can be kept to the greatest extent.

A method of inhibiting premature aging of human skin caused by exposure to infrared radiation comprising contacting the skin with a composition containing a therapeutically-effective amount of at least one protective compound chosen from baicalin, phloretin and neohesperidin dihydrochalcone, as well as combinations thereof.

A flavonoid solubilization agent capable of highly solubilizing flavonoids such as isoflavone, baicalin, rutin and naringin whose solubility is generally low; and a method of effecting the above solubilization. Flavonoids can be solubilized by causing a flavonoid and soybean saponin and/or malonyl isoflavone glycoside to be co-present in an aqueous medium.

The invention relates to a detection method for simultaneously determining the metabolic products of seven CYP450 enzyme probe substrate in human liver microsomes, and belongs to the technical field of biological detection. The detection method comprises the following steps: performing incubation on specificity probe substrates of CYP450 enzyme and the human liver microsomes for different periods of reaction time to generate corresponding metabolic products, using Zaltoprofen as an interior label, adopting a high performance liquid chromatography-tandem mass spectrometry after protein precipitation pretreatment, and thus simultaneously detecting the concentrations of the metabolic products of seven probe substrates. The method disclosed by the invention is high in specificity, high in sensitivity and simple and convenient in operation, and has already successfully been applied to the research of baicalin on CYP450 enzyme inhibiting action of the human liver microsomes.

The invention relates to a simple and effective method for preparing high-purity baicalin, and relates to an extraction method of medicinal herb. The method comprises the steps of: extracting the medicinal herb with aqueous solution to obtain extract, adsorbing the extract with screened macroporous adsorbent resin, eluting with 0-30% ethanol water solution to remove impurities, then eluting with 40-60% ethanol water solution, concentrating the eluate under reduced pressure, then carrying out freeze drying to obtain a crude product with baicalin content more than 80%, and recrystallizing the crude product with ethanol/water/acetic acid solvent system to obtain the light yellow product, the purity of which is more than 98% detected by high-performance liquid chromatography. The method provided by the invention is simple in process, low in cost, mild in condition and environment-friendly, and is more suitable for industrial production of high-purity baicalin.

The invention relates to a sun cream formula based on natural plant components and a preparation method of the sun cream formula. The sun cream formula based on natural plant components is characterized in that the sun cream comprises glycerol, xanthan gum, isopropyl myristate, rutin extract, C14-22 alcohol, bisabolol, green tea extract, methyl glucoside sesqui-stearate, methyl glucoside sesqui-stearate polyoxyethylene (20) ether, vitamin E, titanium dioxide, phenoxyethanol, aloe extract, baicalin, bayberry extract, daily fragrance compound, imidazolidinyl urea and water. The chemical composition is abandoned, and the sun cream is produced from natural, green and safe plant extracts, so that the sun cream does not influence the body, is natural and sun-resistant and can effectively prevent ultraviolet rays from hurting the human body and protect the skin.

The invention discloses a washing and disinfecting solution for household tableware, belonging to the field of commodity chemicals. The washing and disinfecting solution comprises, by weight, 2% to 5% of trisodium phosphate, 1% to 5% of sodium carbonate, 0.1% to 1% essence, 0.1% to 1% of an antiseptic, 0.5% to 1% of a handguard factor and 10% to 5% of AES; the washing and disinfecting solution further comprises Chinese herbal extractants, i.e., paeonol and baicalin. The washing and disinfecting solution provided by the invention has both functions of washing and disinfecting, enables washing and disinfection to be completed at the same time and has the advantages of conservation of water, easy utilization and no harmful ingredients to a human body.

The invention discloses a pharmaceutical composition with the effects on eliminating heat, reducing fire and detoxifying, a preparation method and a quality control method thereof. The crude drugs of the pharmaceutical composition of the invention comprise coptis, Chinese rhubarb and scutellaria; the preparation method comprises the steps that: the three raw materials are respectively added with water and decocted for 2 to 3 times; for each time, 6 to 9 times of water is added and decoction is done for 1 to 2 hours; the decoction solutions of each raw material are mixed and filtered; the filtrate is condensed till obtaining an approximate relative density of 1.25 (measured under 65 to 75 DEG C), and then sprayed and dried to obtain dry extract; the three dry extracts are added with proper amount of cane sugar and dextrin, well mixed, pelletized and then dried so as to obtain 1000g of granules, and finished product is obtained. The invention adopts high performance liquid chromatography to determine the content of baicalin. The pharmaceutical composition of the invention has good effect on eliminating heat, reducing fire and detoxifying.