4 results about "Terbinafine" patented technology

The invention discloses an application of celecoxib or a pharmaceutical salt thereof in preparation of an antifungal drug synergist. An antifungal drug is selected from an azole antifungal drug, an allylamine antifungal drug or an echinocandin antifungal drug. The azole antifungal drug is selected from the group consisting of fluconazole, voriconazole, itraconazole, posaconazole and isavuconazole; the allylamine antifungal drug is selected from terbinafine; the echinocandin antifungal drug is selected from caspofungin. In-vivo and in-vitro experiments prove that when the celecoxib is combined with the azole antifungal drug and the allylamine antifungal drug terbinafine, a synergistic antifungal effect is shown, and when the celecoxib is combined with the echinocandin antifungal drug caspofungin, an additive effect is shown. Celecoxib and fluconazole are combined for use, so that the survival rate of fungal infected animals can be increased, and toxicity to wax moth larvae and mammalian cells is low.

The invention discloses an application method for controlling cotton verticillium wilt by utilizing terbinafine to target verticillium dahliae sterol binding protein VdPBP1, and relates to the technical field of cotton control, and the method comprises the following application steps: S1, confirming the characteristics of a terbinafine medicament; s2, formulating a terbinafine application scheme; and S3, verification and guarantee of prevention and control effects. According to the method, theoretical support is provided for precise prevention and control; the EC50 of the terbinafine is 10.8 ng / mL, the dosage of the medicament can be greatly reduced, the monovalence of the terbinafine is 30.4 yuan / g, so that the large-scale application cost is lower, the terbinafine is only combined with verticillium dahliae VdPBP1 and blocks mediated electron transfer of the verticillium dahliae VdPBP1, and the existing medicaments such as phenazino-1-carboxylic acid can inhibit histone acetylation and benomyl has wide action targets of interfering microtubulin, so that the application range of the medicament is widened. Non-target organisms are easily influenced; moreover, an ergosterol synthesis pathway is an essential pathway for fungi, and the VdERG1 is a single copy gene in verticillium dahliae, so that pathogenic bacteria are difficult to generate drug resistance through gene mutation, and prevention and control nodes widely cover the whole growth period.

The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a marbofloxacin, terbinafine and / or clotrimazole and dexamethasone.

The present invention relates to a composition for use in the treatment of a fungal infection comprising a polymer capable of forming nanoparticles and terbinafine, or derivative or salt thereof, wherein the nanoparticles are formed with and / or in the presence of terbinafine, or derivative or salt thereof, and where the composition comprises: a) a ratio of terbinafine, or derivative or salt thereof, to polymer in the range of about 1:2 to 1:4; and b) up to about 30% (v / v) alcohol. The composition is particularly suited as a topical treatment for fungal nail or skin infections. The invention also relates to methods of producing such compositions and combinations which can be used to produce said same.