Compound terbinafine emulsifiable paste and preparation method thereof
The technology of terbinafine and terbinafine hydrochloride is applied in the directions of pharmaceutical formulations, emulsion delivery, medical preparations containing active ingredients, etc., and can solve the problems of low patient compliance, large side effects and high recurrence rate, To achieve the effect of low recurrence rate, fast onset and short course of treatment
Inactive Publication Date: 2008-05-21
林华清
View PDF0 Cites 4 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Griseofulvin and others are effective in the treatment of athlete's foot in the early stage, but they have large side effects; later, azole drugs such as miconazole nitrate, ketoconazole, bifonazole, etc. are used, which can only inhibit bacteria under normal circumstances, but cannot kill bacteria , so the use cycle is 2-4 weeks longer, the recurrence rate is high, and the patient's compliance is low
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0022] Embodiment 1: 1000 grams of cream is made of the following raw materials in parts by weight: 5 grams of terbinafine hydrochloride, 0.2 grams of clobetasol propionate, and the rest is an O / W type emulsion matrix.
Embodiment 2
[0023] Example 2: 1000 grams of cream is made from the following raw materials in parts by weight: 8 grams of terbinafine hydrochloride, 0.4 grams of clobetasol propionate, and the rest are O / W emulsion bases.
Embodiment 3
[0024] Example 3: 1000 grams of cream is made of the following raw materials in parts by weight: 10 grams of terbinafine hydrochloride, 0.5 grams of clobetasol propionate, and the rest are O / W emulsion-type bases.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention discloses a terbinafine compound preparation for treating eczema, dermatitis, body ringworm, tinea cruris, tinea manus and pedis and the preparation method; the invention mainly uses terbinafine hydrochloride and clobetasol propionate or triamcinolone acetonide acetate, which is further matched with O / W emulsion matrix for the preparation of cream. The invention is characterized by fast onset of action, short treatment course and low recurrence rate for treating skin fungal infection with local inflammatory or chronic eczema.
Description
technical field [0001] The invention relates to a cream for external use, in particular to a compound terbinafine cream mainly used for treating skin fungal infection accompanied by local inflammation or chronic eczema and a preparation method thereof. Background technique [0002] Among the patients, tinea pedis has the highest incidence rate of skin fungal infection. According to the survey, in every 10 people, at least 3 people suffer from mild or severe tinea pedis. Especially modern people like to wear leather shoes, sneakers, so that athlete's foot takes place throughout the year. Griseofulvin and others are effective in the treatment of athlete's foot in the early stage, but the side effects are large; later, azole drugs such as miconazole nitrate, ketoconazole, bifonazole, etc. are used, which can only inhibit bacteria under normal circumstances, but cannot kill bacteria , so the use cycle is 2-4 weeks long, the recurrence rate is high, and the patient's compliance ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): A61K31/58A61K31/573A61K9/107A61K47/34A61P17/00A61P31/10A61K31/137A61K47/26
Inventor 林华清
Owner 林华清