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2531 results about "Propionate" patented technology

The propionate /ˈproʊpiəneɪt/, or propanoate ion, is C₂H₅COO⁻ (the conjugate base of propionic acid). A propionic, or propanoic, compound is a small salt or ester of propionic acid. In these compounds, propionate is often written in shorthand, as CH₃CH₂CO₂ or simply EtCO₂.

Gene products of bacillus licheniformis which form odorous substances and improved biotechnological production methods based thereon

The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and / or isobutyric acid (as part of the catabolism of valine and / or isoleucine), 3) butanol and / or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and / or 5) cadaverine and / or putrescine (as parts of the catabolism of lysine and / or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
Owner:BASF AG

Human sweat malodor counteractant composition and process for using same

InactiveUS6379658B1Increase in level of perceived pleasantnessMalodor-reducing concentrationBiocideCosmetic preparationsFuranPropionate
Described is a process and compositions for counteracting human sweat malodor. The compositions containing at least 10 weight percent of either 3,7-dimethyl-2,6-nonadienenitrile or 3,7-dimethyl-2,6-octadienenitrile. Additional ingredients may be added including napthyl methyl ether, methyl beta-naphthyl ketone, benzyl acetone, methanoinden propionates, methyl ionone, tetramethylnaphtho furan, ethylene glycol cyclic ester of dodecanedioic acid, 1-cyclohexadecen-6-one, 1-cycliheptadecen- 10-one, and corn mint oil. These compositions are applied to either fabric or a defined surface area of the human epidermis.
Owner:INTERNATIONAL FLAVORS & FRAGRANCES

Melamine-formaldehyde microcapsule slurries for fabric article freshening

Described is a method for freshening fabric articles by means of spraying the articles with an aqueous slurry of microcapsules having rupturable melamine-formaldehyde polymeric walls, containing substantive and efficacious functional substances, e.g., malodour counteractants and / or fragrances. The slurry may optionally contain non-confined functional substances, e.g. malodour counteractants and / or fragrances. The method is effective for the deposition of effectively-rupturable malodour suppressant and / or fragrance emitting microcapsules onto fabrics wherein the resulting emitted fragrance activity and / or malodour counteractant activity is long-lasting and where the resulting substantive aroma is aesthetically pleasing over the long period of time for which it is effective. Also described are efficacious and substantive malodour counteractant compositions useful for the aforementioned process containing a malodour composition composed of zinc ricinoleate and at least one of: 1-cyclohexylethan-1-yl butyrate; 1-cyclohexylethan-1-yl acetate; 1-cyclohexylethan-1-ol; 1-(4′-methylethyl)cyclohexylethan-1-yl propionate; and / or 2′-hydroxy-1′-ethyl(2-phenoxy)acetate. In addition, described are efficacious microcapsule slurries useful for the aforementioned process containing microcapsules having melamine-formaldehyde polymeric capsule walls with the microcapsules being in contact with one or more polymeric silicone phospholipids.
Owner:INTERNATIONAL FLAVORS & FRAGRANCES

Anhydrous insect repellent composition

There is provided a topical composition that comprises (a) a substantially anhydrous insect repellent selected from the group consisting of ethyl 3-(N-butylacetylamino) propionate or a derivative thereof, p-menthane-3,8-diol, hydroxyethyl isobutyl piperidine carboxylate (1-piperidine carboxylic acid), and mixtures thereof, and (b) a non-volatile solvent. A second embodiment of the present composition includes the same insect repellent, and a volatile solvent, and, optionally, a film former. A third embodiment includes the same insect repellent, a non-volatile solvent, a volatile solvent, and, optionally, a film former.
Owner:AVON PROD INC

Prepn process of 3-hydroxy propionate and propylene glycol

The present invention is process of preparing 3-hydroxy propionate and 1, 3-propylene glycol with epoxide as material. The present invention prepares 3-hydroxy propionate with epoxide, CO and alcohol under the action of cobalt catalyst and co-catalyst, and prepares 1, 3-propylene glycol under the action of 3-hydroxy propionate hydrogenating catalyst. The present invention has the advantages of simple reaction apparatus, simple operation, mild reaction condition, high catalyst activity, no environmental pollution, low production cost, etc.
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Compounds containing S-N-valeryl-N-{[2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and cations

A compound of an angiotensin receptor antagonist (ARB), a neutral endopeptidase inhibitor (NEPi) and one or more monovalent cations are useful for the treatment of hypertension and / or heart failure. ARB includes S—N-valeryl-N-{[2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine in the anion form, NEPi includes (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester in the anion form and cation includes monovalent cations such as Na+. The compound includes trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate] hemipentahydrate.
Owner:NOVARTIS PHARM CORP

Stabilized insulation composition

A composition comprising:(a) polyethylene;(b) as a first antioxidant, a thiobisphenol;(c) as a second antioxidant, a compound containing 3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate in the molecule;(d) as a third antioxidant, distearyl thiodipropionate; and(e) an organic peroxide,with the proviso that each antioxidant is present in an amount of about 0.01 to the about 0.2 part by weight and the organic peroxide is present in an amount of about 0.5 to about 3 parts by weight, all per 100 parts by weight of polyethylene.
Owner:NIPPON YUNIKAA

Preparation method and application of nano-modified PTFE and polyester-based composite film for preventing fan blades from icing

ActiveCN106313811ASolving non-adhesive technical problemsConvenient engineering constructionSynthetic resin layered productsLaminationPolyesterComposite film
The invention provides a preparation method and application of a nano-modified PTFE and polyester-based composite film for preventing fan blades from icing. The method includes the steps of PTFE film modification, lamination complexing and photo-crosslinked adhesive application. A modifier is prepared from antimony-doped tin oxide nano-crystals, nano-titanium dioxide, nano-silicon carbide, an organic fluorine waterproofing agent and pentaerythritol tri-(3-aziridinyl)-propionate; in lamination complexing, a bonding complexing agent is prepared from 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, vinyl acetate, ethyl carbamate, alpha-linolenic acid, (2)ethoxylated bisphenol A dimethacrylate, trimethylolpropane triacrylate and benzoyl peroxide; a photo-crosslinked adhesive is prepared from a poly[butyl acrylate-glycidyl methacrylate-n-butoxy methacrylamide]copolymer, vinyl acetate, butyl acrylate, an acrylate derivative, a photoinitiator and dimethylformamide. The method and the composite film solve the non-adhesion problem that a PTFE film can not be pasted on the surfaces of fan blades with an adhesive directly.
Owner:NANJING HAOHUI HI TECH CO LTD

Photoresist stripper compositions

A photoresist stripper composition is made up of a mixture of an acetic acid ester, gamma-butyrolactone (GBL), and a non-acetate ester or a poly alkyl alcohol derivative. The acetic acid ester may be at least one of n-butyl acetate, amyl acetate, ethyl aceto-acetate, and isopropyl acetate. The non-acetate ester may be at least one of ethyl lactate (EL), ethyl-3-ethoxy propionate (EEP) and methyl-3-methoxy (MMP). The poly alkyl alcohol derivative may be at least one of propylene glycol monomethyl ester (PGME) and propylene glycol monomethyl ester acetate (PGMEA).
Owner:SAMSUNG ELECTRONICS CO LTD

Non-aqueous electrolyte lithium secondary battery

A lithium secondary battery has a cathode made of carbon material capable of occluding or emitting a lithium ion, a cathode made of lithium-contained oxide, and a non-aqueous electrolyte. The non-aqueous electrolyte includes a lithium salt containing LiPF6 and LiBF4; and a non-linear carbonate-based mixed organic solvent in which (a) a cyclic carbonate having ethylene carbonate or a mixture of ethylene carbonate and propylene carbonate and (b) a propionate-based ester such as ethyl propionate are mixed at a volume ratio (a:b) in the range from about 10:90 to about 70:30. This lithium secondary battery ensures excellent high-rate charging / discharging characteristics and improved life cycle and low-temperature discharging characteristics since it includes a predetermined mixed organic solvent not including a linear carbonate. Also, since gas generation is restrained at a high temperature, a battery set may be mounted in a more improved way.
Owner:LG CHEM LTD

Alcohol-soluble aqueous composite plastic ink for gravure and making method thereof

The invention discloses a gravure alcohol aquosity composite plastic ink, which comprises the following parts: polybasic allyl propionate copolymerized resin, polyketone resin, dye, dispersant, adhesion accelerating and chelant and alcohol. The invention makes ink possess excellent alcohol solubility and solvent releasing property, which improves ink fluidity and adhesion effectively.
Owner:CHENGDU XINJIN TUOZHAN PRINTING INK

Cement concrete superplasticizer and method for preparing same

The invention discloses a concrete superplasticizer and a preparation method. Based on weight proportion, 1-50% of nitrogen-containing functional monomer a, 5-50% of unsaturated carboxylic acid and the derivative b of the unsaturated carboxylic acid, 15-94% of polyoxyethylene vinyl propionate ester ene single-ether and the derivative c of the polyoxyethylene vinyl propionate ester ene single-ether, as well as 0-50% of allyl sulfonate d are mixed to prepare a mixed monomer solution; the initiator which takes up 0.5-15% of the total weight of the mixed monomer, and the chain transfer agent which takes up 0-15% of the total weight of the mixed monomer are added into the mixed monomer solution so as to prepare the concrete super plasticizer through ternary or quaternary copolymerization. Without going through analysis purification, the invention can directly obtain the product and has simple synthetic process, less equipment investment, simple operation and easily controlled reaction conditions; the obtained product has better compatibility with cement and good adaptability with other additives, and is free from segregation and bleeding phenomena; the product also has good concrete slump retentivity and high water reduction rate.
Owner:SHENZHEN OCEANPOWER NEW MATERIALS TECH

Beta (3,4-dihydroxyphenyl)-alpha-hydroxyisopropyl propionate and its synthesis

The invention relates to effective components of root of red-rooted salvia to treat disease and its chemical structure and synthesize technique. It is used to treat heart and blood vessel of brain diseases. Filter the main metabolite-beta(-3,4- dihydric phenyl)-alpha hydric propionic acid isopropyl ester in human blood serum after taking medicine. The purity is 98.0%. The results demonstrate the medicine to have varies function in blood vessel dilatation, anti cerebral ischemia, oxidation resisting in vitro, and protect heart and brain and remission the diabetes caused miocardial infarction.
Owner:NORTHWEST UNIV

Method for preparing high-efficiency water-reducing agent of poly-carboxylic acid

The invention discloses a preparation method for a polycarboxylate high-performance water reducer, comprising the following steps: based on weight proportion, mixing 5-50% of unsaturated carboxylic acid, a derivative a of the unsaturated carboxylic acid, 45-95% of polyoxyethylene vinyl propionate ester, a derivative b of the polyoxyethylene vinyl propionate ester, as well as 0-30% of propyl sulfonate c to prepare a mixed monomer solution; then adding the initiator which takes up 0.5-15% of the total weight of the mixed monomer solution, and the chain transfer agent which takes up 0-15% of thetotal weight of the mixed monomer solution into the mixed monomer solution so as to prepare the polycarboxylate high-performance water reducer through binary or ternary copolymerization. The polycarboxylate high-performance water reducer disclosed in the invention can be widely applied to grout, mortar, concrete, gypsum and coal-water slurry, so that the mixed material can have higher mobility tosignificantly reduce the actual water consumption in the mixing process and effectively improve the concrete strength and durability, thereby showing the advantages of low mixing amount, high dispersion and high slump retaining performance.
Owner:SHENZHEN OCEANPOWER NEW MATERIALS TECH

Synergistically-effective composition of zinc ricinoleate and one or more substituted monocyclic organic compounds and use thereof for preventing and/or suppressing malodors

InactiveUS20050106192A1Eliminate perceptionReduction of perceptionCosmetic preparationsToilet preparationsPolymer scienceEthyl group
Described are synergistically-effective compositions consisting essentially of zinc ricinoleate or solutions thereof and one or more of the substituted monocyclic organic compounds: 1-cyclohexylethan-1-yl butyrate; 1-cyclohexylethan-1-yl acetate; 1-cyclohexylethan-1-ol; 1-(4′-methylethyl)cyclohexylethan-1-yl propionate; and / or 2′-hydroxy-1′-ethyl(2-phenoxy)acetate and uses of same and compositions containing same for preventing and / or suppressing malodors. Also described for the purpose of application to an inanimate laminar substantially solid surface are malodor-suppressing composition-containing stick articles containing an ester-terminated polyamide or an amide-terminated polyamide structural support polymer in combination with the aforementioned synergistically-effective zinc ricinoleate-substituted monocyclic organic compound composition. Also described is a package for conveniently handling the aforementioned stick article.
Owner:INTERNATIONAL FLAVORS & FRAGRANCES

Fresh-keeping method for fresh wet noodle

The invention relates to a method for keeping raw wet noodle fresh, which includes the steps that: (1) before dough making, ultraviolet lamp is switched on to irradiate the dough for 30min to 1.5h; (2)during the dough making, purified water or sterile water with an amount controlled between 25 to 32 percent is added to the dough and at least one of the three antistaling agents, salt, sodium dehydroacetate and calcium propionate in proportions respectively of 2 to 7 percent, 0.02 to 0.05 percent and 0.1 to 0.3 percent, is added to the water; additionally, 0.1 to 0.3 percent of phosphate, 0.1 to 0.3 percent of sucrose ester, 0 to 0.3 percent of guar gum and 0 to 0.3 percent of edible alkali as well as 5 to 10 percent of wheat gluten powder are added; (3) sterilization treatment is applied to cooking equipment, strip press and the like and noodle strip after pressing is thermally insulated and cooked; (4) asepsis treatment is applied to wet noodle strip and the moisture of the product is controlled between 18 to 28 percent; (5) sterilization is applied to the product before packaging. The method of the invention does not affect the flavor and color of products and the raw wet noodle is characterized by bright appearance, cream white color and strong tenacity and has a shelf life of two months at normal temperature and as long as six months at the temperature below 10 DEG C (cold storage).
Owner:CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY

Controlled release composition

InactiveUS20080254124A1Easy for to follow prescribed regimenConstant of releasePowder deliverySolution deliveryEthyl(hydroxyethyl)celluloseCellulose acetate
A composition for controlled delivery of at least one active substance into an aqueous medium by erosion at a preprogrammed rate of at least one surface of the composition, comprising a matrix comprising the active substance, the matrix being erodible in the aqueous medium in which the composition is to be used, and a coating having at least one opening exposing at least one surface of said matrix, the coating comprising a first cellulose derivative which has thermoplastic properties and which is substantially insoluble in the aqueous medium in which the composition is to be used, and at least one of a second cellulose derivative which is soluble or dispersible in water, a plasticizer, and a filler. The coating is a coating which crumbles and / or erodes upon exposure to the aqueous medium such as a body fluid. The first cellulose derivative may be, e.g., ethylcellulose, cellulose acetate, cellulose propionate or cellulose nitrate, and the second cellulose derivative may be, e.g. methylcellulose, carboxymethylcellulose or salts thereof, cellulose acetate phthalate, microcrystalline cellulose, ethylhydroxyethylcellulose, ethylmethylcellulose, hydroxyethylcellulose, hydroxyethylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylcellulose or hydroxymethylpropylcellulose.
Owner:EGALET LTD

Cellulose acetate film for use in liquid crystal displays

A liquid crystal device having a plurality of pixel electrodes for transmitting light, a first panel having an activation portion for selectively activating the plurality of pixel electrodes, an orientation layer formed on the activation portion, a light shielding pattern formed on the orientation layer, a second panel having a second orientation layer, a liquid crystal formed between the first and second panels, a polarizing plate or a color filter and a protective film on at least one of the aforementioned surfaces wherein the protective layer includes a cellulose ester selected from the group consisting of cellulose acetate, cellulose formate, cellulose propionate, cellulose butyrate, ethyl cellulose, methyl cellulose and benzyl cellulose having an inherent viscosity of from about 1.0 to less than 2.0 dl / g.
Owner:EASTMAN CHEM CO

Electrolyte for rechargeable battery

An electrolyte for a rechargeable battery includes 20-70% by volume of at least two cyclic carbonates selected from ethylene carbonate, propylene carbonate, vinylene carbonate or butylenes carbonate, 30-80% by volume of an ester selected from propyl propionate, propyl acetate, butyl acetate or a mixture thereof, and a lithium salt.
Owner:EXA ENERGY TECH +1

Cake and processing process thereof

The invention relates to a cake and a processing process thereof. The cake comprises, by weight, 100 parts of low-gluten flour, 80-100 parts of egg white, 70-75 parts of egg yolk, 80-100 parts of sugar, 15-20 parts of milk, 15-20 parts of salt, 15-20 parts of whole milk powder, 5-10 parts of baking powder, 25-30 parts of honey, 8-10 parts of baking soda, 40-50 parts of oil, 5-10 parts of calcium propionate, 0.1-0.2 part of potassium sorbate and 10-15 parts of water. The cake is formed by fermentation, filling, primary baking, decapping, demolding, cooling, slicing, secondary baking, cooling, quick freezing, sterilization and packaging. The secondary baking process is added in the processing process so that the cake is crisp in taste from outside to inside and is a novel cake. Besides, thecake is attractive in appearance and good in taste, the grease content is low, dosage of a preservative is little, and compounding of calcium propionate and potassium sorbate enables the dosage of the preservative to be reduced and enables a shelf life to be prolonged.
Owner:邱万来

Extruded hard pellet feed for lactating sows and preparation method thereof

The invention discloses an extruded hard pellet feed for lactating sows, which is prepared by the following raw materials in parts by weight: 50-55 parts of corn, 3-4.5 parts of imported super steam fish meal, 3-5 parts of fermented soya bean meal, 8-10 parts of flour, 10-15 parts of wheat, 13.5-15.1 parts of non-transgenic soya bean, 2-4 parts of rapeseed meal, 5-10 parts of extruded-soybean, 1-2 parts of mineral substance premix, 0.2-0.3 parts of vitamins premix, 1.0-2.0 parts of calcium hydrogen phosphate, 2.5-4 parts of soybean oil, 1-2 parts of calcium propionate and 0.1-0.2 parts of oligosaccharide. The extruded hard pellet feed is prepared by tempering the raw materials in the formula by using a double-shaft squeezing well-done extruder under a certain condition and then curing under a certain curing condition. The crude protein of the extruded hard pellet feed is greater than 16.2%, the curing degree is above 80%, the extruded hard pellet feed has comprehensive nutrition and extrusion, the anti-nutrition factors are destroyed, and after the extruded hard pellet feed is used for feeding pregnant sows, the birth weights of piglets are above 1.6 kg in average.
Owner:安徽天邦饲料科技有限公司

High-toughness polylactic acid resin and preparation method thereof

The invention provides a high-toughness polylactic acid resin and a preparation method thereof. The high-toughness polylactic acid resin is prepared from polylactic acid, methyl methacrylate-butadiene-styrol copolymer as toughener, citrate plasticizer and a mixture of pentaerythrite tetra[beta-(3,5-di-tert-butyl-4-hydroxy)propionate) and tris(2,4-di-tert-butylphenyl)phosphite as antioxidant. The preparation method comprises the following steps: mechanically mixing the polylactic acid, the toughener, the plasticizer and the antioxidant, and melting and processing by using a double screw extruder. The invention has the advantages of simple process and easy acquisition of materials, and obviously overcomes serious defects of the toughness and brittleness of polylactic acid. Compared with the material prepared on the basis of pure polylactic acid, the breaking elongation of the material of the invention is increased form 5.7% to 315%, and the impact strength is increased from 4.7KJ / m<2> to 104.2KJ / m<2>. The prepared high-toughness polylactic acid resin can be used for preparing films, plates, sheets and foam and injection molding parts and used in automobiles, writing materials, toys, household appliances and the like.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Low-smell vehicle polypropylene composite material and its preparation method

The invention discloses a low-smell vehicle polypropylene composite material and its preparation method and is characterized in that the low-smell vehicle polypropylene composite material comprises the following components: by weight, 50-85% of polypropylene resin, 5-25% of a mineral filler, 0-20% of glass fiber, 0.6-4.5% of a smell absorption masterbatch, 0-1.5% of zinc ricinoleate, 0-2% of abietate, 5-15% of a flexibilizer, 0-1% of an anti-oxidant 1010, 0-5% of a toner, and other auxiliary agents. The polypropylene is one or a combination of co-polypropylene or high-crystallized homo-polypropylene with the crystallization degree being 50%-70%. The mineral filler is one or more of powdered steatile, calcium carbonate or mica powder. The anti-oxidant 1010 is tetra[beta-(3,5-di-t-butyl-4-hydroxyphenyl)propionate]pentaerythritol ester. The composite material provided by the invention has excellent comprehensive properties and has a characteristic of low smell grade.
Owner:SUZHOU SUNWAY POLYMER

Non-aqueous electrolyte lithium secondary battery

A lithium secondary battery has an anode, a cathode, a separator between the anode and the cathode and a non-aqueous electrolyte. The non-aqueous electrolyte includes a lithium salt; and a non-linear carbonate-based mixed organic solvent in which (a) a cyclic carbonate compound, and (b) a propionate-based compound are mixed at a volume ratio (a:b) in the range from about 10:90 to about 70:30. The cathode has a current density in the range from about 3.5 to about 5.5 mAh / cm2 and a porosity in the range from about 18 to about 35%. This battery may be manufactured as a high-loading lithium secondary battery.
Owner:LG ENERGY SOLUTION LTD

Waterproof rubber material

The invention discloses a waterproof rubber material. The waterproof rubber material is prepared from the following raw materials by weight: 7 to 8 parts of polyethylene glycol terephthalate, 3 to 4 parts of trioctyl citrate, 1 to 2 parts of rosin, 24 to 27 parts of polyacrylonitrile, 1 to 2 parts of sodium diacetate, 12 to 13 parts of graphite, 3 to 4 parts of fly ash bead, 0.7 to 1 part of sodium dodecyl sulfate, 42 to 55 parts of liquid acrylonitrile-butadiene rubber, 0.6 to 1 part of methacrylic acid, 52 to 60 parts of acrylonitrile-butadiene rubber, 20 to 255 parts of butadiene styrene rubber, 5 to 6 parts of nanometer silica sol, 3 to 4 parts of tetramethyl-thiuram disulfide, 2 to 3 parts of diglycol, 6 to 8 parts of VAE emulsion, 14 to 16 parts of activated clay, 5 to 7 parts of barium titanate, 7 to 9 parts of magnesium hydroxide and 0.2 to 0.3 part of calcium propionate. The waterproof rubber material prepared in the invention has good waterproof performance and acid resistance, oil resistance and flame retardation performance, can perfectly meet requirements of production and is worth popularization.
Owner:安徽创奇乐智能游乐设备有限公司

Preparation method of 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribo-gamma-lactone

The invention provides a preparation method of 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribo-gamma-lactone (sofosbuvir). The method comprises the following steps: adding alkali into a mixed solution of L-alanine isopropyl ester or an acid salt thereof and phenyl dichlorophosphate for reacting to obtain (S)-2-phenoxy-chloro-phosphoryl amino isopropyl propionate, reacting the (S)-2-phenoxy-chloro-phosphoryl amino isopropyl propionate with 4-trifluoromethylphenol in the presence of alkali at the temperature of 0-10 DEG C to obtain racemic (S)-2-[(4-trifluoromethyl-phenoxyl)-phenoxy-phosphoryl amino)]alanine isopropyl ester, dissolving the racemic (S)-2-[(4-trifluoromethyl-phenoxyl)-phenoxy-phosphoryl amino)]alanine isopropyl ester into an ether or alkane solvent at the normal temperature, cooling to 50-10 DEG C below zero, and separating (S)-2-[(S)-(4-trifluoromethyl-phenoxy)]-phenoxy-phosphoryl amino)]alanine isopropyl ester out; and reacting the (S)-2-[(S)-(4-trifluoromethyl-phenoxy)]-phenoxy-phosphoryl amino)]alanine isopropyl ester with (2'R)-2'-deoxy-2'-fluoro-2'-methyluridine in the presence of organic alkali with high steric hindrance to obtain the 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribo-gamma-lactone. The method has the advantages of simple steps, mild reaction and suitability for industrial production.
Owner:苏州东南药业股份有限公司

Microorganism bacterium agent for processing thick oil sewage and preparation method thereof

The invention relates to the biological treatment for oil extraction wastewater, which in detail relates to a bacterial agent for treating thick oil wastewater and the method for preparing the same. The comprised components and their proportion by weight are as follows: pseudomonas aeruginosa 5-10%, bacillus subtilis 10-15%, lichen bacilli 5- 15%, Citrobacter propionate tumefaciens 10- 15%, liquid gold tumefaciens 10- 20%, annular gemma bacillus 5- 10%, wilting Bacillus pumilus 5- 10%, spherical arthrobacter 5- 10%, crabstick tumefaciens 5- 10%, and hot ground anaerobic rod baceria 10- 15%. It is prepared by activating bacteria, shake-flask culturing, expanding propagating and mixing. The cooperation action is strong, the biological surface activating agent generating- bacteria can enlarge the dissolution of hydrocarbon petroleum in water and make it is easier for hydrocarbon petroleum to contact with bacteria; the anaerobic bacteria can improve the biodegradation of thick oil wastewater; the degradation perfomace of aerobic bacteria is good and suitable for biological treatment for thick oil wastewater.
Owner:SHENYANG INST OF APPL ECOLOGY CHINESE ACAD OF SCI
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