66 results about "Propionates" patented technology

The invention discloses an ethylene-vinyl acetate copolymer, an ethylene-vinyl alcohol copolymer and a preparation method thereof, and belongs to the field of polymers. Comprising the following steps: putting a mixture containing an initiator, a chain transfer agent, a solvent and vinyl acetate into a closed container, introducing ethylene gas, and carrying out pressurized polymerization to obtain the ethylene-vinyl acetate copolymer, the initiator is selected from at least one of lauroyl peroxide, benzoyl peroxide, azodiisobutyronitrile and azobisisoheptonitrile; the chain transfer agent is selected from the group consisting of 2-dimethylaminoethyl acetate and / or 2-dimethylaminoethyl propionate. The preparation method of the low-branching-degree EVA has the characteristics of mild conditions, strong controllability, simplicity in operation and large-scale application prospect. The invention also provides an ethylene-vinyl alcohol copolymer prepared from the prepared EVA through alcoholysis reaction, and the ethylene-vinyl alcohol copolymer has the characteristics of high molecular weight, narrow distribution, good appearance and the like, and meets the application requirements of commercial EVOH.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

A non-aqueous electrolyte solution for a lithium secondary battery and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution for a lithium secondary battery includes a lithium salt, an organic solvent containing a carbonate compound and a propionate compound, a first additive containing a compound represented by the following Formula 1, and a second additive containing 1,3,6-hexanetricarbonitrile, wherein the first additive and the second additive are present in a weight ratio of 1:1.1 to 1:5.5,NC—R—CH═CH—R—CN  [Formula 1]wherein, in Formula 1,R is an unsubstituted or substituted alkylene group having 1 to 5 carbon atoms.

The present invention discloses a process for preparing compound of Lifitegrast of Formula (I) or a salt thereof. Briefly, The present invention discloses a process for the preparation of Lifitegrast of Formula I from alkyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6- carboxamido)-3-(3 (methylsulfonyl)phenyl)propanoate a compound of Formula V via 5 transesterification of Phenyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6- carboxamido)-3-(3)(methylsulfonyl)phenyl) propanoate of Formula IV.

The invention relates to phosphine ligands and their use in the carbonylation of acetylene / ethylene for the synthesis of acrylate / propionate. The phosphine ligands according to the invention are represented by formulas I to VIII. The invention describes the use of these phosphine ligands in combination with palladium catalysts for carbonylation reactions of acetylene or ethylene for the production of acrylate or propionate compounds. The processes are characterized by high catalytic efficiency, excellent product yields, outstanding selectivity, and ease of implementation. Particular advantages include improved reaction kinetics due to the optimized ligand structures, economical process control due to high catalyst productivity, and a broad range of applications for various acrylate and propionate derivatives. The invention is particularly suitable for industrial synthesis processes in fine chemical production.

The invention relates to 2-[({3-amino-5H-pyrrolo[2,3-b]pyrazin-2-yl}formamido) methyl]-6- (4-{bis[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino}piperidine-1-carbonyl)-1,3- diethyl-1H-1,3-benzodiazol-3-ium chloride hydrochloride. The invention further relates to a method for preparing this salt, to pharmaceutical compositions containing it and to its 5 use in methods for treating a respiratory disease or condition.

A method for controlling phytopathogenic pests on cereals, wherein the pest, their habitat, breeding grounds, their locus or the plants to be protected against pest attack, the soil or plant propagation material are treated with an effective amount of a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one as compound I, and 2) one fungicidal compound II selected from [2, 2-bis(4-fluorophenyl)-1-methyl-ethyl]2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound 11-1) and [(1S)-2,2-bis(4-fluorophenyl)-1-methyl-ethyl](2S)-2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound II-2).

The present technology is directed to polypropionate lactone stereotetrads of Formula (I) (or a pharmaceutically acceptable salt and / or solvate thereof) which are significant intermediates for multiple synthetic applications.

The present disclosure provides a method of treating hair loss in a subject in need thereof, comprising administering to the surface of the subject an effective amount of picosterone-17a-propionate and an effective amount of minoxidil. The present disclosure also provides surface pharmaceutical formulations comprising picosterone-17a-propionate, minoxidil, and one or more pharmaceutically acceptable carriers.

The invention provides an immunochromatography test strip for detecting clobetasol propionate in cosmetics and a method for quantitatively detecting clobetasol propionate in cosmetics. According to the invention, a hollow gold nano-labeled material is applied to immunodetection of glucocorticoid clobetasol propionate for the first time, and an immunochromatography test strip with high sensitivity, quantitative function and strong specificity is constructed. The test strip can complete detection within 15 minutes, has high detection sensitivity, and realizes accurate quantification in a range of 0.01-25 ng / mL; meanwhile, the method is high in anti-interference capacity, the detection recovery rate of actual cosmetic samples reaches up to 89%-107%, the false positive rate and the false negative rate are both 0, reliability is good, and a powerful screening analysis tool is provided for rapid screening and quantitative detection of clobetasol propionate addition in cosmetics.

The invention relates to an adhesive composition comprising: a) At least one polymer P, b) A stabilizer S comprising b1) At least one first stabilizer S1 and b2) At least one second stabilizer S2, which is different from the at least one stabilizer S1 wherein the first stabilizer S1 is a non-sulfur containing compound having at least two phenolic groups selected from ethylenebis(oxyethylene) bis[3-(5-tert-butyl-4-hydroxy-m- tolyl)propionate] and pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4- hydroxyphenyl)propionate)the second stabilizer S2 is a sulfur containing compound selected from thiodiethylene bis[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)propionate] and dilauryl 3,3'-thiodipropionate; wherein the at least one polymer P is selected from at 25 °C solid non-functionalized and functionalized polyolefins;

The present disclosure provides a method of treating hair loss in a subject in need thereof, comprising topically administering to the subject an effective amount of cortexolone-17α-propionate and an effective amount of minoxidil. The present disclosure further provides a topical pharmaceutical formulation comprising cortexolone-17α-propionate, minoxidil, and one or more pharmaceutically acceptable carriers.

The present invention relates to a kind of C3 trifluoropropionyloxylation reaction of N substituted indole, 3 trifluoropropionyloxy 2 oxindole and its preparation method and application, belong to the field of heterocyclic compound synthesis technology, solve the existing method using transition metal catalyst, unfriendly to the environment, limited substrate range, harsh reaction conditions, many by-products, low yield of target product, low purity and other problems. The inventive method adopts bis(trifluoropropionate) iodobenzene as oxidant and fluorine source, reacts in an organic solvent, and is applicable to various N substituted indoles, including N methyl, N ethyl, N propyl, N butyl and N benzyl indole. The inventive method does not need to use transition metal catalyst, has higher environmental protection and operational safety, mild reaction conditions, high yield, good selectivity, few by-products, can efficiently and environmentally friendly prepare 3 trifluoropropionyloxy 2 oxindole and its derivatives, for drug development and organic synthesis provide important technical means.

The invention discloses zwitter-ion-based hydrogel and a preparation method and application thereof.The preparation method includes the steps that zwitter-ion monomers are stirred and dissolved in water under the ice-water bath condition, and a zwitter-ion monomer solution is obtained; injecting the obtained zwitter-ion solution into a mold, and placing in a water bath kettle at 37-60 DEG C for 24-72 hours to obtain zwitter-ion-based hydrogel; wherein the zwitter-ions are selected from at least one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfonic acid propyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-[[2-(methacryloyloxy) ethyl] dimethyl ammonium] propionate. The zwitter-ion hydrogel material provided by the invention has a compression elastic modulus of 22.2-47.8 kPa, which is matched with the elastic modulus of breast tissues, and the hydrogel material has good self-repairing property, and it is found that the compression modulus after compression is equivalent to an initial state value; in addition, the hydrogel also has good tensile property and can bear the action of tensile force.

The present invention relates to fungicidal compositions comprising as component 1) the compound (I) methyl (2Z)-3-methoxy-2-[(4-methylbiphenyl-3-yl)oxy]prop-2-enoate) and as active component 2) as active component 2) (I-1) methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2- hydroxy-3-(1,2,4-triazol-1-yl)propanoate or (I-2) 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2- hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid.

The invention discloses a method for preparing propionate through ethylene hydrogen esterification reaction, which is characterized in that raw materials ethylene, carbon monoxide and low-carbon alcohol are subjected to hydrogen esterification reaction in the presence of a catalyst by taking propionate as a solvent to synthesize propionate, the catalyst is composed of a palladium compound, a naphthyl bidentate phosphine ligand and an acidic auxiliary agent, and the structure of the naphthyl bidentate phosphine ligand is shown in the following formula. Wherein m is 0 or 1, and n is 1 or 2; r1 is selected from phenyl, tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl, and R2 is selected from tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl. According to the method, the naphthyl bidentate phosphine is used as the ligand, the product propionate is used as the reaction solvent, the catalyst activity is high, the yield of the target product propionate is high, and byproducts are few.

The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and / or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to now crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.

A compound of formula (I), or a pharmaceutically acceptable salt thereof, or a tautomer thereof, or a meracemate thereof, or a raceme thereof, or an enantiomer thereof, or a diastereoisomer thereof, or a mixture of these isomers, or a solvate (e.g., hydrate) thereof, or a clathrate thereof, or a co-crystal thereof, or an isotope label thereof, or a nitrogen oxide thereof. The compound has good anti-inflammatory activity, and can effectively treat and / or prevent inflammation, pain and fever. The invention also provides a preparation method, a pharmaceutical composition and application of the compound.

The invention discloses a synthetic method of an aromatic heterocyclic propionic acid compound, which comprises the following steps: selecting a methyl aromatic heterocyclic compound as a raw material, and finally extending two carbon chains by using the acidity of heterocyclic methyl through hydrogen extraction by strong base and reaction with a halogen acetate compound to obtain the aromatic heterocyclic propionic acid ester compound. And further hydrolyzing the heteroaromatic propionate compound to obtain the heteroaromatic propionic acid compound. According to the method, raw materials are easy to obtain, the route is reasonable, simple and convenient, operation is easy, a series of novel aromatic heterocyclic propionic acid compounds can be synthesized through substrate expansion, important intermediate fragments are provided for medicine research and development, and the method has good process amplification feasibility.

The application provides a synthesis method of 2-(phenyl sulfonamide)-3-oxo-3-heterocyclic propionic acid ester compounds and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: adding heterocyclic formyl acetic acid ethyl ester compounds, sulfonamide compounds and a photosensitizer into a solvent to configure a reaction solution, performing reaction under blue light irradiation, and preparing a target product after the reaction is completed. The application avoids the problem of a large amount of by-products caused by various oxidants in a traditional method; the organic photosensitizer 4CzIPN is used as a catalyst, the reaction time is greatly shortened, the reaction can be completed in only 10 minutes, the reaction efficiency is improved, and the product does not have metal residues; the reaction condition is mild, and the reaction can occur at room temperature in an air atmosphere.

The invention discloses an aryloxy phenoxy propionate compound containing straight-chain sulfur and application, the compound is shown as a general formula (I), and substituent groups are selected in the specification. The compound provided by the invention has excellent herbicidal activity.

The invention discloses an aryloxy phenoxy propionate compound and application thereof, the compound is shown as a general formula (I), and substituent groups are selected in the specification. The compound provided by the invention not only has excellent herbicidal activity, but also is safe to crops.

The present invention provides a catalyst for preparing 1,4-pentanediol by hydrogenating levulinate, and its preparation method and application, belonging to the technical field of catalytic hydrogenation. The present invention provides a catalyst comprising Al2O3 nanosheets and metal nanoparticles supported on the Al2O3 nanosheets. Al2O3 nanosheets are a two-dimensional material with a high degree of chemical bond unsaturation on the surface of the sheet, thus containing many oxygen defects and unsaturated five-coordinated Al 3+ sites. Oxygen vacancies and pentacoordinated Al 3+ The sites are conducive to anchoring metal nanoparticles and improving the dispersion of metal nanoparticles, thereby increasing the contact area with the reaction raw materials and improving catalytic activity. In addition, there is a strong metal-support interaction between the metal and the Al2O3 nanosheets to form a metal-Al2O3 interface, so the catalyst has excellent stability.

The invention provides a pharmaceutical composition containing picosterone-17 alpha-propionate, which is prepared from the following raw materials in parts by weight: 0.25 to 15 parts of picosterone-17 alpha-propionate, 1 to 5 parts of medicinal matrix, 8.75 to 80 parts of pharmaceutically acceptable solvent and 20 to 90 parts of pharmaceutically acceptable water, and the pH value of the pharmaceutical composition is 3.0 to 5.0. The pharmaceutically acceptable solvent is isopropanol or a composition of isopropanol and other solvents, and the weight percentage of the pharmaceutically acceptable water is greater than 20%. The invention further provides a preparation method and application of the pharmaceutical composition containing the picosterone-17alpha-propionate, the pharmaceutical composition is more beneficial to the active ingredients to play roles, and irritation and side effects caused by pharmaceutical auxiliary materials in the pharmaceutical composition are reduced.

This invention discloses a pharmaceutical composition and its application, characterized by comprising tebufenozide-7-propionate (W6) and a CDK4 / 6 inhibitor. The pharmaceutical composition is used in the preparation of drugs for treating drug-resistant tumors, specifically breast cancer. Low concentrations (0.1 µM–1.0 µM) of W6 alone have no significant antitumor activity against breast cancer. However, W6 can significantly enhance the anti-breast cancer activity of CDK4 / 6 inhibitors when used in combination with them by inhibiting the drug efflux protein P-glycoprotein and regulating apoptosis and survival / proliferation signaling pathways.

The present invention relates to the grinding aid used in the cement industry, in the clinker grinding phase of cement production and in the preparation of cementitious systems. In particular, the present invention relates to the grinding aid and synthesis method consisting of the Triisopropanol amine monopropanoate composition obtained as a result of the esterification reaction of Triisopropanol amine with propanoic acid.

The disclosure relates to pharmaceutical formulations comprising of lidocaine and halobetasol propionate, methods of making such formulations, and methods of using such formulations in the treatment of hemorrhoids.

The application belongs to the technical field of carbon neutralization and environmental protection, and particularly relates to a trimethylolpropane tris(2-piperazinyl propionate) and application thereof as a CO2 absorbent. The trimethylolpropane tris(2-piperazinyl propionate) provided by the application has the following advantages when applied to the capture of CO2 in a mixed gas as a CO2 absorbent: (1) high absorption capacity and fast speed; (2) fast desorption rate and high efficiency; (3) low desorption temperature and low regeneration energy consumption; (4) low volatility, less loss and strong cycle stability. The trimethylolpropane tris(2-piperazinyl propionate) provided by the application has a wide application prospect in the field of carbon neutralization and CO2 capture.

The present invention belongs to the field of pharmaceutical synthesis technology, and in particular to a tirofiban intermediate compound and a preparation method thereof. The present invention uses 4-pyridine butanol and p-toluenesulfonyl chloride as starting materials to react and obtain a new tirofiban intermediate compound. At the same time, the present invention provides a new intermediate compound and N-n-butylsulfonyl-L-tyrosine ethyl ester to react and prepare a key tirofiban intermediate (S)-2-(butylsulfonylamino)-3-(4-(4-(pyridine-4-yl)butoxy)phenyl)propionic acid (ester), and the intermediate is further reacted to obtain tirofiban hydrochloride. The new intermediate synthesis method provided by the present invention is simple, and the new intermediate is used to prepare a short synthetic route for tirofiban, with high yield, mild reaction conditions, stable process, and is suitable for a large number of industrialized production.

The invention discloses a duloxetine hydrochloride key intermediate synthesis method, which comprises: in a hydrogen atmosphere, under the action of a compound represented by a formula V, carrying out an asymmetric catalytic hydrogenation reaction on a compound represented by a formula I to obtain a compound represented by a formula II, the method has the advantages of mild reaction conditions, simple operation, high catalytic efficiency, high yield, high product purity and high ee value, and is very suitable for industrialization.