110 results about "Propionates" patented technology

An artificial synthesis method for malonyl-CoA and use thereof are provided. By means of heterologous expression of an aminotransferase and a malonyl-CoA reductase, an artificial synthesis pathway for synthesizing malonyl-CoA by using β-alanine (β-ala) as a precursor is constructed as follows: firstly, under catalysis of a transaminase, β-ala transfers amino groups to α-ketonic acid (such as pyruvic acid, oxaloacetic acid, or α-ketoglutaric acid, etc.), to form an intermediate product 3-oxopropanoate and a corresponding amino acid; the 3-oxopropanoate generates malonyl-CoA under the action of the malonyl-CoA reductase. This pathway addresses the defects of the natural malonyl-CoA synthesis pathway, such as low carbon utilization, consumption of energy substance ATP, release of greenhouse gas CO2, and strict regulation of pathway enzymes, a pyruvate dehydrogenase (PDH) and an acetyl-CoA carboxylase (ACC), thereby achieving high yielding of products using malonyl-CoA as a precursor, including flaviolin, octanoic acid, phloroglucinol, pentadecaheptaene, natamycin, and spinosad.

An electrochemical device, including a cathode, an anode and an electrolytic solution. The anode includes a carbon material and hydroxyalkyl methylcellulose. The electrolytic solution includes propionate. The electrolytic solution further includes one or more of the following: LiPF6, LiBF4, LiPO2F2, LiSbF6, LiAsF6, LiC4F9SO3, LiClO4, LiB(C2O4)2, or LiN(CxF2x+1SO2)(CyF2y+1SO2). x and y are integers from 1-5.in

The invention relates to the technical field of tackifiers, and discloses a preparation method and application of an organic silicon tackifier. Vinyl isophthalic acid and epoxy chloropropane are subjected to an esterification reaction under catalysis of tetraethylammonium bromide to obtain vinyl epoxypropyl isophthalate; and carrying out polymerization reaction on the modified rosin, allyl propionate modified rosin and alkenyl silicone oil under the initiation of azodiisobutyronitrile to obtain the organic silicon tackifier. And adding the organic silicon tackifier into the base material, and uniformly mixing to obtain the silicone rubber adhesive. The organic silicon tackifier prepared by the invention contains ester groups, carboxyl groups and epoxy groups with relatively strong polarity, and is easy to chemically react with a base material or form secondary valence bonds, so that the adhesion of a silicon rubber adhesive is enhanced, and the organic silicon tackifier is easy to tangle with each other after being added into silicon rubber to form a network structure, so that the mechanical property of the silicon rubber is enhanced. The tackifier prepared by the invention has excellent mechanical property and adhesive property when being applied to silicone rubber.

The invention discloses a method for synthesizing loxoprofen sodium by using a resin catalyst, and belongs to the field of medical chemical synthesis. The preparation method comprises the following steps: synthesizing 2-methylene cyclopentanone through methylenation reaction of cyclopentanone, paraformaldehyde and amine; the preparation method comprises the following steps: reacting 4-halogenated phenylacetate with methyl iodide to synthesize 2-(4-halogenated phenyl) propionate; a target intermediate 2-(4-((5-oxocyclopentyl-1-alkenyl) methyl) phenyl) propionate is generated through a Heck coupling reaction; further reducing to 2-(4-((2-oxygen cyclopentyl) methyl) phenyl) propionate through a catalytic hydrogenation reaction; and finally, carrying out a salt forming reaction to obtain loxoprofen sodium. The method adopts the self-made resin catalyst, is efficient and environment-friendly, has good yield and purity, and is suitable for industrial production.

The invention discloses a preparation method of (R)-2-(4-chloro-2-methylphenoxy) propionate compounds, which comprises the following steps: providing compounds with structures shown in formulas I and II: R-OH formula I, in the formula I, R is selected from C1-C18 alkyl substituted or unsubstituted by hydroxyl,-(R1-O) m-R1-OH,-(R4-O-CO-O) n-R4-OH,-(R4-O-CO-R10) w-OH,-R7-O (-CO-O-(R6-O-) p) q-R7-OH, R1 is alkylene of C2-C4, m is an integer of 4-28, and R2 is an integer of 4-28; r4 is a C3-C15 alkylene group or # imgabs0 # n is an integer from 1 to 20; r10 is # imgabs1 # w which is an integer from 1 to 15; r < 6 > is isopropylidene, R < 7 > is C2-C5 alkylene, p is an integer of 1-5, and q is an integer of 5-30; in the formula II, R2 and R3 are independently selected from H, C1, Br and I, and at least one of R2 and R3 is C1 or Br or I; compounds shown in the formula I and the formula II react under the catalytic condition to generate a compound shown in the formula III, wherein R, R2 and R3 are defined as above; the compound shown in the formula III and 4-chloro-o-cresol are catalyzed by an etherification catalyst to generate a compound shown in a formula IV, and in the formula IV, R is defined as above; # imgabs2 #

The invention discloses an ethylene-vinyl acetate copolymer, an ethylene-vinyl alcohol copolymer and a preparation method thereof, and belongs to the field of polymers. Comprising the following steps: putting a mixture containing an initiator, a chain transfer agent, a solvent and vinyl acetate into a closed container, introducing ethylene gas, and carrying out pressurized polymerization to obtain the ethylene-vinyl acetate copolymer, the initiator is selected from at least one of lauroyl peroxide, benzoyl peroxide, azodiisobutyronitrile and azobisisoheptonitrile; the chain transfer agent is selected from the group consisting of 2-dimethylaminoethyl acetate and / or 2-dimethylaminoethyl propionate. The preparation method of the low-branching-degree EVA has the characteristics of mild conditions, strong controllability, simplicity in operation and large-scale application prospect. The invention also provides an ethylene-vinyl alcohol copolymer prepared from the prepared EVA through alcoholysis reaction, and the ethylene-vinyl alcohol copolymer has the characteristics of high molecular weight, narrow distribution, good appearance and the like, and meets the application requirements of commercial EVOH.

The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and / or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to new crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

A non-aqueous electrolyte solution for a lithium secondary battery and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution for a lithium secondary battery includes a lithium salt, an organic solvent containing a carbonate compound and a propionate compound, a first additive containing a compound represented by the following Formula 1, and a second additive containing 1,3,6-hexanetricarbonitrile, wherein the first additive and the second additive are present in a weight ratio of 1:1.1 to 1:5.5,NC—R—CH═CH—R—CN  [Formula 1]wherein, in Formula 1,R is an unsubstituted or substituted alkylene group having 1 to 5 carbon atoms.

The present invention discloses a process for preparing compound of Lifitegrast of Formula (I) or a salt thereof. Briefly, The present invention discloses a process for the preparation of Lifitegrast of Formula I from alkyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6- carboxamido)-3-(3 (methylsulfonyl)phenyl)propanoate a compound of Formula V via 5 transesterification of Phenyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6- carboxamido)-3-(3)(methylsulfonyl)phenyl) propanoate of Formula IV.

The invention relates to phosphine ligands and their use in the carbonylation of acetylene / ethylene for the synthesis of acrylate / propionate. The phosphine ligands according to the invention are represented by formulas I to VIII. The invention describes the use of these phosphine ligands in combination with palladium catalysts for carbonylation reactions of acetylene or ethylene for the production of acrylate or propionate compounds. The processes are characterized by high catalytic efficiency, excellent product yields, outstanding selectivity, and ease of implementation. Particular advantages include improved reaction kinetics due to the optimized ligand structures, economical process control due to high catalyst productivity, and a broad range of applications for various acrylate and propionate derivatives. The invention is particularly suitable for industrial synthesis processes in fine chemical production.

The invention relates to 2-[({3-amino-5H-pyrrolo[2,3-b]pyrazin-2-yl}formamido) methyl]-6- (4-{bis[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino}piperidine-1-carbonyl)-1,3- diethyl-1H-1,3-benzodiazol-3-ium chloride hydrochloride. The invention further relates to a method for preparing this salt, to pharmaceutical compositions containing it and to its 5 use in methods for treating a respiratory disease or condition.

The invention provides polysulfydryl-containing alkyl silane as well as a preparation method and application thereof, and relates to the technical field of sulfydryl alkyl silane preparation. The preparation method of the polymercapto-containing alkyl silane comprises the following steps: mixing pentaerythritol tetra (3-mercapto alkyl propionate) and a catalyst under a stirring condition, preheating a mixed solution, dropwise adding isocyanate group-containing silane into the mixed solution, heating, preserving heat and stirring to obtain the polymercapto-containing alkyl silane. The alkyl silane containing multiple sulfydryl groups prepared by the method contains multiple sulfydryl groups, and the preparation method is simple, mild in reaction condition, easy to obtain raw materials, low in cost and suitable for industrial large-scale production. Meanwhile, the reaction process is easy to control, the operation safety is high, the product has no obvious foul smell, and the problem of unpleasant smell commonly accompanied by the traditional sulfydryl alkyl compound is solved.

The invention discloses a method for refining a crude halobetasol propionate, and belongs to the technical field of drug purification. The method for refining a crude halobetasol propionate comprises the following steps: mixing the crude halobetasol propionate with a single organic solvent, then heating and stirring, then filtering while hot, and then cooling to precipitate crystals to obtain a fine halobetasol propionate. The content of a single impurity in the fine halobetasol propionate obtained by the method is less than 0.1%.

A method for controlling phytopathogenic pests on cereals, wherein the pest, their habitat, breeding grounds, their locus or the plants to be protected against pest attack, the soil or plant propagation material are treated with an effective amount of a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one as compound I, and 2) one fungicidal compound II selected from [2, 2-bis(4-fluorophenyl)-1-methyl-ethyl]2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound 11-1) and [(1S)-2,2-bis(4-fluorophenyl)-1-methyl-ethyl](2S)-2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound II-2).

The present technology is directed to polypropionate lactone stereotetrads of Formula (I) (or a pharmaceutically acceptable salt and / or solvate thereof) which are significant intermediates for multiple synthetic applications.

The present disclosure provides a method of treating hair loss in a subject in need thereof, comprising administering to the surface of the subject an effective amount of picosterone-17a-propionate and an effective amount of minoxidil. The present disclosure also provides surface pharmaceutical formulations comprising picosterone-17a-propionate, minoxidil, and one or more pharmaceutically acceptable carriers.

The combined use of biomarkers for cancer diagnosis, and in particular, the combined use of (a) 3-oxopropanoate and at least one of (b) a ketone body selected from beta-hydroxybutyrate, acetoacetate and combinations thereof, or (c) a medium chain fatty acid selected from octanoate, decanoate and combinations thereof, as a biomarker for the diagnosis of cancer. An in vitro method for diagnosing cancer in a subject based in the particular biomarker combination.

The invention provides an immunochromatography test strip for detecting clobetasol propionate in cosmetics and a method for quantitatively detecting clobetasol propionate in cosmetics. According to the invention, a hollow gold nano-labeled material is applied to immunodetection of glucocorticoid clobetasol propionate for the first time, and an immunochromatography test strip with high sensitivity, quantitative function and strong specificity is constructed. The test strip can complete detection within 15 minutes, has high detection sensitivity, and realizes accurate quantification in a range of 0.01-25 ng / mL; meanwhile, the method is high in anti-interference capacity, the detection recovery rate of actual cosmetic samples reaches up to 89%-107%, the false positive rate and the false negative rate are both 0, reliability is good, and a powerful screening analysis tool is provided for rapid screening and quantitative detection of clobetasol propionate addition in cosmetics.

The invention relates to an adhesive composition comprising: a) At least one polymer P, b) A stabilizer S comprising b1) At least one first stabilizer S1 and b2) At least one second stabilizer S2, which is different from the at least one stabilizer S1 wherein the first stabilizer S1 is a non-sulfur containing compound having at least two phenolic groups selected from ethylenebis(oxyethylene) bis[3-(5-tert-butyl-4-hydroxy-m- tolyl)propionate] and pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4- hydroxyphenyl)propionate)the second stabilizer S2 is a sulfur containing compound selected from thiodiethylene bis[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)propionate] and dilauryl 3,3'-thiodipropionate; wherein the at least one polymer P is selected from at 25 °C solid non-functionalized and functionalized polyolefins;

The present disclosure provides a method of treating hair loss in a subject in need thereof, comprising topically administering to the subject an effective amount of cortexolone-17α-propionate and an effective amount of minoxidil. The present disclosure further provides a topical pharmaceutical formulation comprising cortexolone-17α-propionate, minoxidil, and one or more pharmaceutically acceptable carriers.

The present invention relates to a kind of C3 trifluoropropionyloxylation reaction of N substituted indole, 3 trifluoropropionyloxy 2 oxindole and its preparation method and application, belong to the field of heterocyclic compound synthesis technology, solve the existing method using transition metal catalyst, unfriendly to the environment, limited substrate range, harsh reaction conditions, many by-products, low yield of target product, low purity and other problems. The inventive method adopts bis(trifluoropropionate) iodobenzene as oxidant and fluorine source, reacts in an organic solvent, and is applicable to various N substituted indoles, including N methyl, N ethyl, N propyl, N butyl and N benzyl indole. The inventive method does not need to use transition metal catalyst, has higher environmental protection and operational safety, mild reaction conditions, high yield, good selectivity, few by-products, can efficiently and environmentally friendly prepare 3 trifluoropropionyloxy 2 oxindole and its derivatives, for drug development and organic synthesis provide important technical means.

The invention discloses zwitter-ion-based hydrogel and a preparation method and application thereof.The preparation method includes the steps that zwitter-ion monomers are stirred and dissolved in water under the ice-water bath condition, and a zwitter-ion monomer solution is obtained; injecting the obtained zwitter-ion solution into a mold, and placing in a water bath kettle at 37-60 DEG C for 24-72 hours to obtain zwitter-ion-based hydrogel; wherein the zwitter-ions are selected from at least one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfonic acid propyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-[[2-(methacryloyloxy) ethyl] dimethyl ammonium] propionate. The zwitter-ion hydrogel material provided by the invention has a compression elastic modulus of 22.2-47.8 kPa, which is matched with the elastic modulus of breast tissues, and the hydrogel material has good self-repairing property, and it is found that the compression modulus after compression is equivalent to an initial state value; in addition, the hydrogel also has good tensile property and can bear the action of tensile force.

The invention belongs to the technical field of chemical synthesis, and discloses a method for synthesizing 3-hydroxy-3-alkyl propionate based on a continuous flow reaction technology. According to the method, a continuous flow reaction device is adopted for synthesis, acetate, lithium diisopropylamide and an aldehyde compound are taken as raw materials, and 3-hydroxy-3-alkyl propionate is synthesized through lithium-hydrogen exchange and alkyl aldehyde addition reaction. According to the method provided by the invention, the reaction process is easy to control, the danger coefficient of the reaction operation and process is greatly reduced, and the safety and reliability of the reaction are improved. Meanwhile, by the method, the reaction efficiency is remarkably improved, and the synthesis time is shortened from dozens of hours to dozens of minutes, even dozens of minutes; in addition, different 3-hydroxy-3-alkyl propionate products can be prepared by introducing different substrates and switching, the applicability is high, and the industrial application value is high.

The present invention relates to fungicidal compositions comprising as component 1) the compound (I) methyl (2Z)-3-methoxy-2-[(4-methylbiphenyl-3-yl)oxy]prop-2-enoate) and as active component 2) as active component 2) (I-1) methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2- hydroxy-3-(1,2,4-triazol-1-yl)propanoate or (I-2) 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2- hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid.

The invention discloses a method for preparing propionate through ethylene hydrogen esterification reaction, which is characterized in that raw materials ethylene, carbon monoxide and low-carbon alcohol are subjected to hydrogen esterification reaction in the presence of a catalyst by taking propionate as a solvent to synthesize propionate, the catalyst is composed of a palladium compound, a naphthyl bidentate phosphine ligand and an acidic auxiliary agent, and the structure of the naphthyl bidentate phosphine ligand is shown in the following formula. Wherein m is 0 or 1, and n is 1 or 2; r1 is selected from phenyl, tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl, and R2 is selected from tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl. According to the method, the naphthyl bidentate phosphine is used as the ligand, the product propionate is used as the reaction solvent, the catalyst activity is high, the yield of the target product propionate is high, and byproducts are few.

A method for preparing 1,3-propanediol with a high space-time yield, in which A methyl 3-hydroxypropionate solution is pumped into a tubular fixed-bed reactor loaded with a surface modifier-coated nano-Cu-based catalyst for continuous hydrogenation to obtain a reaction mixture, where the catalyst includes Cu as active component, a metal oxide XOn / 2 as additive and a SiO2—SnO2 composite carrier. The reaction mixture is subjected to rectification to separate light components from heavy components, where the light components include methanol, n-propanol, methyl propionate, methyl 3-hydroxypropionate and 1,3-propanediol, and the heavy components include 1,3-propanediol mono-propionate and 1,3-propanediol mono-3-hydroxypropionate. The heavy components are fed back to the tubular fixed-bed reactor for secondary hydrogenation, and the light components are separated to obtain 1,3-propanediol.

The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and / or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to now crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.

A compound of formula (I), or a pharmaceutically acceptable salt thereof, or a tautomer thereof, or a meracemate thereof, or a raceme thereof, or an enantiomer thereof, or a diastereoisomer thereof, or a mixture of these isomers, or a solvate (e.g., hydrate) thereof, or a clathrate thereof, or a co-crystal thereof, or an isotope label thereof, or a nitrogen oxide thereof. The compound has good anti-inflammatory activity, and can effectively treat and / or prevent inflammation, pain and fever. The invention also provides a preparation method, a pharmaceutical composition and application of the compound.

The present invention discloses a preparation method of chiral 3-(N-methyl-1,2,3,4-tetrahydroisoquinoline) propionate benzenesulfonate, which comprises the following steps: (1) firstly, carrying out a nitrogen alkylation reaction on compound 4 and 3-chloropropionate, then carrying out an asymmetric reduction reaction under the action of a chiral catalyst, trichlorosilane and an auxiliary agent, and finally forming a salt with oxalic acid to obtain compound 5; (2) alkalizing compound 5 and then carrying out a quaternization reaction with methyl benzenesulfonate, and purifying the reaction product in a purification solvent to obtain the target compound 1. The method of the present invention has easily available raw materials, mild reaction conditions, low production cost, high purity of the obtained quaternary ammonium salt with a cis configuration, and can be used to prepare qualified cis-atracurium besylate.