37 results about "Propionates" patented technology

The invention discloses an ethylene-vinyl acetate copolymer, an ethylene-vinyl alcohol copolymer and a preparation method thereof, and belongs to the field of polymers. Comprising the following steps: putting a mixture containing an initiator, a chain transfer agent, a solvent and vinyl acetate into a closed container, introducing ethylene gas, and carrying out pressurized polymerization to obtain the ethylene-vinyl acetate copolymer, the initiator is selected from at least one of lauroyl peroxide, benzoyl peroxide, azodiisobutyronitrile and azobisisoheptonitrile; the chain transfer agent is selected from the group consisting of 2-dimethylaminoethyl acetate and / or 2-dimethylaminoethyl propionate. The preparation method of the low-branching-degree EVA has the characteristics of mild conditions, strong controllability, simplicity in operation and large-scale application prospect. The invention also provides an ethylene-vinyl alcohol copolymer prepared from the prepared EVA through alcoholysis reaction, and the ethylene-vinyl alcohol copolymer has the characteristics of high molecular weight, narrow distribution, good appearance and the like, and meets the application requirements of commercial EVOH.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

The invention provides an immunochromatography test strip for detecting clobetasol propionate in cosmetics and a method for quantitatively detecting clobetasol propionate in cosmetics. According to the invention, a hollow gold nano-labeled material is applied to immunodetection of glucocorticoid clobetasol propionate for the first time, and an immunochromatography test strip with high sensitivity, quantitative function and strong specificity is constructed. The test strip can complete detection within 15 minutes, has high detection sensitivity, and realizes accurate quantification in a range of 0.01-25 ng / mL; meanwhile, the method is high in anti-interference capacity, the detection recovery rate of actual cosmetic samples reaches up to 89%-107%, the false positive rate and the false negative rate are both 0, reliability is good, and a powerful screening analysis tool is provided for rapid screening and quantitative detection of clobetasol propionate addition in cosmetics.

The invention relates to an adhesive composition comprising: a) At least one polymer P, b) A stabilizer S comprising b1) At least one first stabilizer S1 and b2) At least one second stabilizer S2, which is different from the at least one stabilizer S1 wherein the first stabilizer S1 is a non-sulfur containing compound having at least two phenolic groups selected from ethylenebis(oxyethylene) bis[3-(5-tert-butyl-4-hydroxy-m- tolyl)propionate] and pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4- hydroxyphenyl)propionate)the second stabilizer S2 is a sulfur containing compound selected from thiodiethylene bis[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)propionate] and dilauryl 3,3'-thiodipropionate; wherein the at least one polymer P is selected from at 25 °C solid non-functionalized and functionalized polyolefins;

The present disclosure provides a method of treating hair loss in a subject in need thereof, comprising topically administering to the subject an effective amount of cortexolone-17α-propionate and an effective amount of minoxidil. The present disclosure further provides a topical pharmaceutical formulation comprising cortexolone-17α-propionate, minoxidil, and one or more pharmaceutically acceptable carriers.

The invention discloses zwitter-ion-based hydrogel and a preparation method and application thereof.The preparation method includes the steps that zwitter-ion monomers are stirred and dissolved in water under the ice-water bath condition, and a zwitter-ion monomer solution is obtained; injecting the obtained zwitter-ion solution into a mold, and placing in a water bath kettle at 37-60 DEG C for 24-72 hours to obtain zwitter-ion-based hydrogel; wherein the zwitter-ions are selected from at least one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfonic acid propyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-[[2-(methacryloyloxy) ethyl] dimethyl ammonium] propionate. The zwitter-ion hydrogel material provided by the invention has a compression elastic modulus of 22.2-47.8 kPa, which is matched with the elastic modulus of breast tissues, and the hydrogel material has good self-repairing property, and it is found that the compression modulus after compression is equivalent to an initial state value; in addition, the hydrogel also has good tensile property and can bear the action of tensile force.

The present invention relates to fungicidal compositions comprising as component 1) the compound (I) methyl (2Z)-3-methoxy-2-[(4-methylbiphenyl-3-yl)oxy]prop-2-enoate) and as active component 2) as active component 2) (I-1) methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2- hydroxy-3-(1,2,4-triazol-1-yl)propanoate or (I-2) 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2- hydroxy-3-(1,2,4-triazol-1-yl)propanoic acid.

The invention discloses a method for preparing propionate through ethylene hydrogen esterification reaction, which is characterized in that raw materials ethylene, carbon monoxide and low-carbon alcohol are subjected to hydrogen esterification reaction in the presence of a catalyst by taking propionate as a solvent to synthesize propionate, the catalyst is composed of a palladium compound, a naphthyl bidentate phosphine ligand and an acidic auxiliary agent, and the structure of the naphthyl bidentate phosphine ligand is shown in the following formula. Wherein m is 0 or 1, and n is 1 or 2; r1 is selected from phenyl, tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl, and R2 is selected from tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl. According to the method, the naphthyl bidentate phosphine is used as the ligand, the product propionate is used as the reaction solvent, the catalyst activity is high, the yield of the target product propionate is high, and byproducts are few.

The invention discloses a synthetic method of an aromatic heterocyclic propionic acid compound, which comprises the following steps: selecting a methyl aromatic heterocyclic compound as a raw material, and finally extending two carbon chains by using the acidity of heterocyclic methyl through hydrogen extraction by strong base and reaction with a halogen acetate compound to obtain the aromatic heterocyclic propionic acid ester compound. And further hydrolyzing the heteroaromatic propionate compound to obtain the heteroaromatic propionic acid compound. According to the method, raw materials are easy to obtain, the route is reasonable, simple and convenient, operation is easy, a series of novel aromatic heterocyclic propionic acid compounds can be synthesized through substrate expansion, important intermediate fragments are provided for medicine research and development, and the method has good process amplification feasibility.

The invention discloses an aryloxy phenoxy propionate compound containing straight-chain sulfur and application, the compound is shown as a general formula (I), and substituent groups are selected in the specification. The compound provided by the invention has excellent herbicidal activity.

The invention discloses an aryloxy phenoxy propionate compound and application thereof, the compound is shown as a general formula (I), and substituent groups are selected in the specification. The compound provided by the invention not only has excellent herbicidal activity, but also is safe to crops.

This invention discloses a pharmaceutical composition and its application, characterized by comprising tebufenozide-7-propionate (W6) and a CDK4 / 6 inhibitor. The pharmaceutical composition is used in the preparation of drugs for treating drug-resistant tumors, specifically breast cancer. Low concentrations (0.1 µM–1.0 µM) of W6 alone have no significant antitumor activity against breast cancer. However, W6 can significantly enhance the anti-breast cancer activity of CDK4 / 6 inhibitors when used in combination with them by inhibiting the drug efflux protein P-glycoprotein and regulating apoptosis and survival / proliferation signaling pathways.

The present invention relates to the grinding aid used in the cement industry, in the clinker grinding phase of cement production and in the preparation of cementitious systems. In particular, the present invention relates to the grinding aid and synthesis method consisting of the Triisopropanol amine monopropanoate composition obtained as a result of the esterification reaction of Triisopropanol amine with propanoic acid.

The disclosure relates to pharmaceutical formulations comprising of lidocaine and halobetasol propionate, methods of making such formulations, and methods of using such formulations in the treatment of hemorrhoids.

The invention discloses a duloxetine hydrochloride key intermediate synthesis method, which comprises: in a hydrogen atmosphere, under the action of a compound represented by a formula V, carrying out an asymmetric catalytic hydrogenation reaction on a compound represented by a formula I to obtain a compound represented by a formula II, the method has the advantages of mild reaction conditions, simple operation, high catalytic efficiency, high yield, high product purity and high ee value, and is very suitable for industrialization.

The invention provides high polymer material modified organic oleophylic and hydrophobic bentonite and a preparation method thereof, and belongs to the technical field of coating materials, the bentonite is a propylene glycol methyl ether acetate hydrophobization product of sodium bentonite subjected to intercalation modification by a high polymer modifier; the macromolecular modifier is prepared by reacting methacryloyloxyethyl trimethyl ammonium chloride, caprolactone acrylate, gamma-methacryloyloxypropyl trimethoxy silane, bis (dodecyl)-3, 3 '-thiodipropionate, ammonium thioglycolate and an ammonium persulfate initiator. The preparation method of the bentonite comprises the following steps: pre-synthesis of a polymer modifier, preparation and purification of bentonite slurry, intercalation modification of a polymer, and post-treatment and hydrophobization of a modifier. The problems that natural bentonite is high in hydrophilicity and poor in dispersion and early organic bentonite is weak in interface bonding and insufficient in thixotropy are solved from the molecular level, and performance upgrading of lipophilicity, hydrophobicity, dispersion stability and long-acting protection is achieved.

This invention discloses an adhesive for membrane switches and a membrane switch. The adhesive is made from the following components in parts by weight: 45-70 parts of 2-ethylhexyl acrylate, 20-55 parts of hydrogenated styrene-isoprene-styrene block copolymer, 10-20 parts of solvent, 5-10 parts of filler, 5-10 parts of tackifier, and 3-10 parts of curing agent. The combination of 60 parts of 2-ethylhexyl acrylate and hydrogenated styrene-isoprene-styrene block copolymer in the adhesive improves the peel strength; the combination of modified C5 petroleum resin and maleic anhydride grafted modified rosin resin improves the initial tack; and the combination of trimethylolpropane-tris[3-(2-methylacridinyl)propionate] and 2-amino-2-ethyl-1,3-propanediol improves the tensile strength.

The present invention discloses the prodrugs of hexahydro-β-acid compounds, feed composition and use thereof, and a prodrug of hexahydro-β-acid compound of formula (I), or solvates thereof, or feed-acceptable salts thereof, wherein R1 is selected from a substituted or unsubstituted C1-C2 alkyl, and each of R2 and R3 is independently selected from H and a linear or branched C2-C4 carbonyl, wherein the C2-C4 carbonyl is substituted or unsubstituted. Disclosed herein is that the prodrug of a hexahydro-β-acid compound from esterification by aliphatic acid exhibits excellent stability at high temperature to overcome the problem resulting from the degradation of hexahydro-β-acid compound in a high-temperature pelleting process. Furthermore, disclosed herein is that, both propionate and butyrate, the prodrugs of a hexahydro-β-acid compound from esterification by aliphatic acid, and feed-acceptable salt thereof and solvate thereof, are stable in high-temperature feed processing and achieve effects substantially equal to the hexahydro-β-acid compound in farm breeding.

The present invention relates to the topical pharmaceutical composition comprising about 0.001% w / w to about 1% w / w latanoprost and about 1% w / w to about 15% w / w cortexolone-17α-propionate and a pharmaceutically acceptable vehicle comprising one or more solvent and process of its preparation. The invention further relates to the method wherein the composition is suitable for preventing and / or treating hair loss and / or stimulating hair growth. in patients suffering from alopecia, in particular androgenic alopecia (AGA).

The invention discloses a directional preparation process of B crystal form dexamethasone. The process comprises the following steps: by taking 16-dehydropregnanone propionate as a starting material, sequentially performing catalytic dehydrogenation by using steroid 1, 4-dehydrogenase from bacillus subtilis, performing catalytic dehydrogenation by using potassium methyltrifluoroborate / copper acetate / 2, 4-dihydroxyprogesterone propionate as a starting material, and performing catalytic hydrogenation by using potassium methyltrifluoroborate / The preparation method comprises the following steps: preparing dexamethasone free alkali by key steps of stereoselective methylation of a 2, 2 '-bipyridine system, catalysis of 11 beta-hydroxylation by immobilized CYP11B1 monooxygenase, epoxidation of peroxybenzoic acid, ring opening of hydrogen fluoride-ethanol and the like, and finally directionally crystallizing in a system solution consisting of 0.5% malic acid and isopropanol-water in a volume ratio of 3: 1 to obtain the high-purity B crystal form dexamethasone.

A secondary battery includes a non-aqueous electrolyte. The non-aqueous electrolyte includes: fluoroethyl propionate, where the fluoroethyl propionate is selected from the group consisting of 2,2-difluoroethyl propanoate, 2,2,2-trifluoroethyl propionate, and a combination thereof, and based on a total mass of the non-aqueous electrolyte, a mass percentage of the fluoroethyl propionate is 5% to 65%; and ethylene carbonate (EC) and propylene carbonate (PC), where based on the total mass of the non-aqueous electrolyte, the sum of the mass percentages of the ethylene carbonate (EC) and the propylene carbonate (PC) is less than or equal to 15%.

The present application relates to a kind of easily removable self-adhesive and its preparation method and application, belong to self-adhesive technical field.The self-adhesive includes the surface material layer, adhesive layer and release layer arranged in sequence;The adhesive layer is composed of the following weight parts of raw materials: soft monomer 4-8 parts, hard monomer 22-30 parts, functional monomer 22-30 parts, crosslinking aid 10-20 parts, plasticizing aid 1-3 parts, solvent 30-40 parts, initiator 0.8-1.3 parts, catalyst 1-3 parts and antioxidant 1-1.5 parts;Wherein, the crosslinking aid is the composition of oxazoline functional MPEG-MA copolymer, pentaerythritol tri (3-aziridinyl) propionate and linear vinyl silicone oil with mass ratio (0.5-0.8) :1: (1.2-1.5), crosslinking aid balances the initial adhesion, peel strength and no glue residue performance of self-adhesive by synergistic effect when preparing adhesive, improves the easy removal of adhesive layer in self-adhesive.

The present invention relates to a treatment of vaso-occlusive crisis (VOC) associated with Sickle cell disease by administering a therapeutically effective amount of 4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl) propanoate.

Disclosed are activators of the phosphatase PHLPP1 (PH domain and Leucine rich repeat protein phosphatase 1), a widely conserved enzyme involved in the regulation of two signaling networks, mTOR and AMPK, the balance and coordination of which controls the cellular response to either ample or restricted fuel supply to cells. These activators are referred to as SNAP (Snail-derived Activators of PHLPP) compounds as they are based on the structure of a Dormancy Inducing factor (DIF) discovered in hibernating snails. SNAP compounds are demonstrated to increase the activity of both human recombinant PHLPP, and mouse PHLPP1. One such example of a SNAP compound is 3-(2-methyl-8- (2-((oxidanidylsulfonyl)oxy) ethyl)-3,4-dihydro-2H-chromen-2-yl) propanoate-pyridine.

The invention relates to the technical field of coatings, in particular to a multiband synergistic camouflage coating and a preparation method thereof. The invention discloses a multiband synergistic camouflage coating. The wave-absorbing coating is prepared from the following raw materials: acrylic acid modified polyurethane resin, polysilane modified epoxy resin, acrylic acid modified organic silicon resin, wave-absorbing particles, nano titanium dioxide, filler, activated boron nitride nanosheets, graphene oxide, hollow carbon microspheres, pyrrole monomers, an oxidizing agent, nano vanadium dioxide, a dispersing agent, a flatting agent, a defoaming agent, an anti-settling agent, extinction powder and trimethylolpropane tris [ 3-(2-methyl aziridinyl) propionate]. The obtained coating is good in wave absorbing effect, can realize multiband wave absorbing, has the function of reflecting solar radiation, is good in heat stability and scratch-resistant in paint film, and obviously enhances stealth stability; meanwhile, the process is simple and suitable for large-scale popularization and application.

Disclosed is a personal care composition comprising: (a) rosemary extract and (b) retinoid, wherein the weight ratio of the rosemary extract to the retinoid is at least 1:1 and the retinoid is retinyl propionate.

The invention discloses an aryloxy phenoxy propionate compound and application thereof, the compound is shown as a general formula (I), and substituent groups are selected in the specification. The compound provided by the invention not only has excellent herbicidal activity, but also is safe to crops.

The invention discloses a low-sensitivity early-strength polycarboxylate superplasticizer and a preparation method thereof, and belongs to the technical field of concrete admixtures. The water reducing agent is prepared from ethylene glycol monovinyl polyoxyethylene ether, maleoyl chitosan oligosaccharide, 3-[[2-(methacryloyloxy) ethyl] dimethylammonium] propionate, unsaturated carboxylic acid and other raw materials through low-temperature copolymerization in a redox system. Maleoyl chitosan oligosaccharide and a specific cationic monomer are introduced to generate a synergistic effect: the cationic monomer preferentially anchors clay, and a chitosan oligosaccharide derivative provides a rigid skeleton and dynamic dispersion compensation, so that excellent mud resistance, low sensitivity and early strength are jointly realized. The product has strong adaptability to cement, can significantly improve the early strength and workability retention ability of mud-containing aggregate concrete, and is suitable for high-performance concrete engineering under complex raw material conditions.

The invention belongs to the technical field of oil exploitation, and particularly relates to a foaming agent for nitrogen foam fracturing and a preparation method and application thereof. The preparation method comprises the following steps: (1) sequentially adding trimethylolpropane tri (3-aziridinyl propionate), an organic solvent and 1-amino-3, 6, 9, 12, 15, 18-hexaoxaheneicosan-21-acid into a reactor, adjusting the pH value to 2-3 by using hydrochloric acid, and carrying out heat preservation reaction; (2) adding alkyl halide into the reactor, adjusting the pH value to 8-9 by using sodium hydroxide, carrying out heat preservation reaction, irregularly detecting the pH value in the reaction process, and maintaining the pH value to 8-9 by using sodium hydroxide; and (3) carrying out reduced pressure distillation on the mixed solution in the step (2) to obtain a viscous solid, and drying to obtain the foaming agent for nitrogen foam fracturing. The foaming agent for nitrogen foam fracturing has the advantages of good foaming and foam stabilizing effects and large liquid carrying capacity.

The invention belongs to the technical field of organic synthesis and pesticides, and particularly discloses a phenyl-1, 3, 4-oxadiazole-thiopropionate derivative as well as a preparation method and application thereof. The phenyl-1, 3, 4-oxadiazole-thiopropionate compound provided by the invention has a structural general formula as shown in a formula I in the specification, wherein Rx is one or more of H, CH3, Br, Cl or F. The phenyl-1, 3, 4-oxadiazole-thiopropionate compound provided by the invention has excellent herbicidal activity, and has the advantages of high safety, small dosage, low cost and the like. The invention also provides a preparation method and application of the compound.