23 results about "Paraben" patented technology

The invention provides a teak camel moth artificial feeding feed and a teak camel moth artificial feeding method, the feed comprises the following components by weight: 8% of wheat germ powder, 4% of soybean meal, 4% of yeast powder, 2% of casein, 2% of sucrose, 1.8% of agar powder, 1.5% of cellulose, 0.8% of Webster salt, 0.6% of vitamin C, 0.2% of sorbic acid, 0.3% of methyl p-hydroxybenzoate, 0.1% of cholesterol, 0.1% of choline chloride, 0.05% of inositol, 0.01% of folic acid, and the balance of water. And the balance of deionized water. The invention further provides an artificial feeding method of teak camelmoths, and the artificial feeding method comprises the steps of 1, adult mating and egg laying, 2, egg disinfection and incubation and 3, larva rearing. The feed does not contain host material teak leaves, and full-artificial continuous large-scale feeding of the teak camelmoths can be achieved.

A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer containswater at 65 to 85% by mass based on a total mass of the adhesive agent layer,polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer,polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer,polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, anda parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, anda mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.

The disclosure relates to methods for amplifying a target nucleic acid. The methods include performing an amplifying step comprising contacting the nucleic acid with a polymerase, dNTPs, one or more set of primers specific for the nucleic acid, and an amplification enhancer that is methyl paraben or a derivative thereof. Also described are kits and reaction mixtures for the amplification of a target nucleic acid in the presence of the amplification enhancer, as well as methods for enhancing nucleic acid amplification.

The present disclosure provides an oral liquid composition comprising potassium chloride, free of alcohol, free of parabens, and with enhanced stability. The present disclosure further provides methods of using the oral liquid compositions comprising potassium chloride, and which are free of alcohol and parabens, for the treatment of hypokalemia in patients with or without metabolic alkalosis.

Provided herein are substantially crystalline solid forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pen-t-2-enenitrile (identified herein as Compound (I), and also known as PRN 1008 or rilzabrutinib) as a pharmaceutically-acceptable salt selected from an HCI, oxalate, and / or a maleate salt or alternatively, as a pharmaceutically-acceptable methyl paraben co-crystal, and pharmaceutical compositions comprising the substantially crystalline forms.

Disclosed is a thickener dispersion including a thickener including at least one among carboxymethyl cellulose and metal salt of the carboxymethyl cellulose, a change-over-time inhibitor, and an aqueous solvent. The change-over-time inhibitor includes at least one selected from the group consisting of phenoxyethanol, sodium azide, paraben, formaldehyde, 5-chloro-2-methyl-4-isothiazolin-3-one, sodium benzoate, ethylhexylglycerin, and 1,2-hexanediol. The thickener is included in an amount of 0.05 wt % to 3.5 wt % in the thickener dispersion, and the change-over-time inhibitor is included in an amount of 0.05 wt % to 3.0 wt % in the thickener dispersion.

To provide a dispersion liquid containing a paraben, which ensures excellent dispersion of the paraben in water and is capable of maintaining a dispersed state over an extended period of time.SOLUTION: The present invention relates to a dispersion liquid containing: a component (A), a benzyl 4-hydroxybenzoate represented by formula (1) or a salt thereof in an amount of 0.0001-70 mass%; a component (B), a surfactant having an aromatic group in an amount of 0.0001-10 mass%; and water, wherein the average particle diameter of the component (A) is 0.01-20 μm.SELECTED DRAWING: None

The present invention aims at the formulation and manufacture of a new natural shampoo without sulfates and without parabens based on laurel hydrosol which will purify the scalp, eliminate oils and combat the proliferation of bacteria. The shampoo composition provided by the invention contains the following components in mass percentage: 72% laurel hydrosol, 8.5% geranium hydrosol, 9% Sodium Lauroyl Sarcosinate surfactant, 8% Coco Betaine surfactant, 0.2% preservative, 0.7% thickening stabilizer Xanthan Gum, 1% laurel oil macerate and 0.5% laurel essential oil. The physicochemical analysis of the prepared shampoo shows that its pH is 6.90, its density is 0.91, and its foaming power is 210 ml. It is rheologically stable and does not cause skin irritation.

The invention belongs to the technical field of pigment red preparation, and particularly provides a high crystal transformation quality-based quinacridone pigment red surface treatment process, which comprises the following steps: 1) taking a pigment crude product, and carrying out grinding and salt milling to obtain a primary treatment material; and 2) adding a solvent and a MA-HBA derivative into the primary treatment material, stirring for pigmentation, and then filtering and drying to obtain the pigment red, the MA-HBA derivative is prepared by synthesizing methyl p-hydroxybenzoate and 1, 11-undecanediol, and the prepared pigment red has the advantages of good pigmentation effect and good covering power.

Fexofenadine zwitterionic dihydrate form I of formula (I) Paraben-free aqueous pharmaceutical suspension formulations and uses thereof are provided, including JPEG2026501487000031.jpg4390. In certain embodiments, the formulations include polypropylene glycol, edetate disodium, potassium sorbate, xanthan gum, poloxamer 407, titanium dioxide, sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate, artificial raspberry cream flavor, sucrose, xylitol, and purified water. The disclosure also includes methods of making such formulations.

An immediate-release liquid oral suspension of Eslicarbazepine Acetate, containing between about 5 to about 10 g of active ingredient per 100 mL, along with carbomer homopolymer and microcrystalline cellulose as viscosity modifying agents. It may further comprise, parabens as antimicrobial agent, sucralose as a sweetener, and polyethylene glycol 8 stearate as a surfactant. The suspension is designed to provide bioequivalence to marketed Eslicarbazepine Acetate tablets, ensuring rapid drug release and stability over extended storage periods. The pH is adjusted to 3.0-6.5 to maintain stability, with impurities remaining under 0.05% of the eslicarbazepine content after stress storage conditions. This formulation offers an alternative to solid dosage forms for patients with partial-onset seizures.

Provided is a paraben-free aqueous pharmaceutical suspension formulation comprising fexofenadine zwitterionic dihydrate Form I of formula (I)and uses thereof. In certain embodiments, the formulation comprises polypropylene glycol, edetate disodium, potassium sorbate, xanthan gum, poloxamer 407, titanium dioxide, sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate, artificial raspberry cream flavor, sucrose, xylitol, and purified water. The disclosure also includes methods of making such formulations.

The invention discloses a butylparaben cation salt derivative, the structural general formula of which is shown as a formula P. In the formula, R is selected from C1-C12 straight chain or branched chain alkyl with substituent groups, five-membered or six-membered cycloalkyl or aryl with substituent groups, and the C1-C12 straight chain or branched chain alkyl with substituent groups, the five-membered or six-membered cycloalkyl or aryl with substituent groups, the C1-C12 straight chain or branched chain alkyl with substituent groups, the five-membered or six-membered cycloalkyl or aryl with substituent groups, the five-membered or six-membered cycloalkyl or aryl with substituent the substituent group in the five-membered or six-membered naphthenic base or aryl with the substituent group is at least one of hydrogen, halogen and C1-C6 alkyl; a is selected from-CO <-> or-CH2 <->; q is selected from nitrogen or phosphine; x is selected from chlorine or bromine; n is equal to 0-10. According to the invention, the antibacterial property and antibacterial spectrum of the butylparaben are improved, and the butylparaben has the advantages of rapid sterilization and long-acting sterilization, and also has efficient and broad-spectrum sterilization effects.

The utility model discloses a crystallization device for producing methylparaben, which comprises a crystallization barrel, an outer cover plate is arranged on the crystallization barrel, a gear ring is movably connected inside the outer cover plate through a bearing, and an inner cover plate is movably connected inside the gear ring through a bearing. A stirring assembly is movably connected to the bottom of the inner cover plate, the bottom of the stirring assembly extends to the bottom end in the crystallization barrel, a plurality of stirring rods are fixedly connected to the outer side of the stirring assembly, a first gear and a second gear are driven to rotate through rotation of a main shaft, and finally a gear ring, a differential part and a stirring assembly body are driven to rotate; a stirring assembly and a circulating rod are utilized, the stirring rod stirs internal liquid and sucks liquid at the bottom to form circulation at the same time, heating is conducted in the circulation process, the liquid making contact with the inner wall of an electric heating pipeline is continuously changed in the circulation process, and therefore the situation that local overheating is not uniform in temperature can be avoided; and the heating process is relatively smooth and does not influence the crystallization quality.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a methimazole tablet and a preparation process thereof. The methimazole tablet comprises methimazole serving as a main drug, a compound stabilizer, a filling agent, an adhesive, a disintegrating agent and a lubricating agent, and optionally comprises a coating material, wherein the compound stabilizer is a combination of gold paraben acid, phosphatidylcholine and tragacanth gum. The preparation process comprises the steps of adhesive pretreatment, compound stabilizer preparation, mixing and granulation, drying and size stabilization, and total mixing and tabletting, and if the coated tablets are prepared, a coating step is added after tabletting. Through the synergistic effect of the compound stabilizer, degradation of methimazole caused by environmental factors is effectively inhibited, and the stability of the tablet is remarkably improved; the preparation process does not need a multi-layer coating structure, the steps are simplified, the cost is controllable, the medication safety and effectiveness can be guaranteed, the preparation method is suitable for industrial large-scale production, and the stability of the coated tablet can be further enhanced.

The utility model discloses an efficient mixing esterification kettle for methylparaben production, which comprises an esterification kettle, a jacket is mounted outside the esterification kettle, a vertical rotating shaft is rotatably mounted at the top end of the esterification kettle, the bottom end of the vertical rotating shaft extends into the esterification kettle, a buffer container is fixed outside the vertical rotating shaft, and a stirrer is fixed at the bottom end of the vertical rotating shaft. The vertical rotating shaft is hollow and is communicated with the buffer container, the top end of the vertical rotating shaft is connected with the methanol introduction pipe through a rotating joint, and the bottom end of the buffer container is connected with a liquid distributor. The liquid distributor comprises the distribution pipe and the liquid spraying pipe, and the horizontal movable rod with the reset spring and the sealing plug are arranged in the distribution pipe, so that intermittent spraying of methanol can be realized; the pressurizing piston and the elastic telescopic rod in the buffer container can pressurize methanol, so that the mixing effect can be improved, and the production efficiency can be improved.

This invention relates to a gel preparation with pistachio shell extract as the active ingredient which has the effect of inhibiting Staphylococcus aureus bacteria. The gel consists of pistachio shell extract made from a maceration process using 70% alcohol, 5% CMC-Na gel base, 5.0% glycerin humectant, 3.0% propylene glycol, 0.25% methyl paraben preservative and aquades solvent added up to 100%. The gel has antibacterial activity which is characterized by the formation of an inhibition zone against Staphylococcus aureus bacteria. The emergence of this inhibition zone is due to the active compound contained in the gel base diffusing through the media so that it is able to inhibit the growth of Staphylococcus aureus bacteria. The positive control used in this antibacterial test is 1.2% clindamycin phosphate gel.From the results of the antibacterial effectiveness test that has been carried out, it was found that 10% to 25% pistachio shell extract gel can inhibit ≥15mm-24mm of Staphylococcus aureus bacterial growth with Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values ​​of 80% and 100%, respectively.

A hair cleansing composition, comprising: i) 0.2 to 2.5 wt %, preferably from 0.5 to 2 wt %, of a glutamate salt, preferably sodium glutamate, most preferably monosodium glutamate; and ii) a cleansing surfactant; wherein the pH is in the range of from 4.1 to 6, preferably 4.1 to less than 5; and wherein the composition is free from parabens.

The invention relates to the technical field of traditional Chinese medicine gel preparation, in particular to asiaticoside gel and a preparation method and application thereof. The asiaticoside gel is used for preparing a preparation for wound healing and comprises the following components in parts by weight: 0.2-2 parts of an asiaticoside extract or lipidosome with the content of total asiaticoside in an active ingredient being 70-80wt%, 0.2-2 parts of a p-hydroxybenzoate compound, 2-10 parts of glycerol and 5-20 parts of carbomer. The preparation method comprises the following steps: S1, swelling carbomer, and adjusting the pH value to obtain carbomer gel; s2, dissolving the asiaticoside extract or lipidosome and a p-hydroxybenzoate compound into glycerol to obtain a glycerol solution; and S3, adding a glycerol solution into the carbomer gel, and uniformly stirring to obtain the asiaticoside gel. The asiaticoside gel prepared by the invention has the advantages of no toxic or side effect, freshness, transparency, no greasiness and good wound healing effect in the wound healing process.

The embodiment of the invention discloses a preparation method of a gel dressing. A specific embodiment of the method comprises the following steps: preparing a carbomer glue solution in a first preset concentration range; preparing an anhydridized bovine beta-lactoglobulin solution in a second preset concentration range; preparing a nipagin lipid alcohol solution; and preparing the gel dressing according to the prepared carbomer solution, the prepared anhydridized bovine beta-lactoglobulin solution, the prepared nipagin lipid alcohol solution, triethanolamine with a fifth preset weight, glycerol with a second preset volume and purified water. According to the embodiment, the stability and safety of the prepared gel dressing are improved, the irritation to the skin is reduced, the situations that the skin is prone to allergy and the skin barrier is prone to damage are reduced, and then the HPV virus inhibiting effect of the prepared gel dressing is improved.

An objective is to provide an antibacterial hot-melt adhesive that does not undergo phase separation even when heated for a long time, has high safety for the human body, and is able to maintain stable antibacterial properties even when heated for a long time. The objective is achieved by a hot-melt adhesive that includes: a base polymer; a adhesive; and an antibacterial agent that has a paraben structure and that has a 10% weight loss temperature of not lower than 200°C in thermogravimetric measurement, the hot-melt adhesive having a melting viscosity at 140°C of not greater than 20,000 mPa·s.

The present invention relates to a syrup composition comprising paracetamol (I), chlorpheniramine (II), ascorbic acid (III) and one or more pharmaceutically acceptable excipient wherein the syrup composition is particularly free of paraben.

Provided is a paraben-free aqueous pharmaceutical suspension formulation comprising fexofenadine zwitterionic dihydrate Form I of formula (I) and uses thereof. In certain embodiments, the formulation comprises polypropylene glycol, edetate disodium, potassium sorbate, xanthan gum, poloxamer 407, titanium dioxide, sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate, artificial raspberry cream flavor, sucrose, xylitol, and purified water. The disclosure also includes methods of making such formulations.