82 results about "Phosphatidylcholine" patented technology

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The invention relates to a pharmaceutical composition consisting of a liposomal formulation of a phospholipid component and an aqueous phase, wherein the phospholipid component is selected from the group consisting of phosphatidylcholine, and sphingomyelin, and wherein the phospholipid component comprises a saturated or mono-unsaturated (Z / cis) fatty acid having 14 to 20 carbon atoms. The invention further relates to the use of the pharmaceutical composition in treatment of a condition associated with presence of lipopolysaccharide (LPS), particularly endotoxemia.

The application belongs to the technical field of anti-aging skin care product preparation, and discloses a composition containing a composite exosome-polypeptide, a preparation method thereof and application of the composition in cosmetics. The composition contains, in terms of mass fraction, 3.0%-7.0% of an exosome-polypeptide composite wrapped by a biomimetic liposome, 4%-9% of a plant active synergistic extract, 15%-20% of a temperature-sensitive moisturizing sustained-release system, 3%-6% of a lipid barrier repair agent, 0.3%-0.8% of an antioxidant stabilizer, and the rest is a basic base; the exosome is composed of membrane pod huangqi root exosome, salvia miltiorrhiza exosome and long life flower exosome; the polypeptide is composed of palmitoyl tripeptide-5 and acetyl hexapeptide-8; and the biomimetic liposome is composed of phosphatidylcholine, ceramide NP and phytosteryl oleate. The application is compounded by the composite exosome-polypeptide-multiple effect component, hierarchical synergy is achieved, multiple-dimensional aging targets are covered, the transdermal rate is improved, the activity is retained for a long time, the barrier repair and skin quality adaptation are considered, and the anti-aging performance is excellent.

The invention discloses a compound grease feed additive for improving breeding quality of channa maculata and application. The method comprises the following steps: (1) preparing experimental feed; the method comprises the following steps: respectively preparing an experimental group ARA 1.5 added with 1.5% of arachidonic acid and an experimental group ARA + PC added with 1.5% of arachidonic acid and 1.5% of phosphatidylcholine; (2) feeding; (3) after the culture experiment is finished, treating and detecting the channa maculata; (4) carrying out an artificial propagation test; (5) carrying out ovarian steroid synthesis related gene expression detection; and (6) carrying out data statistical analysis. By adding arachidonic acid (ARA) and phosphatidylcholine (PC) into the feed, the breeding performance of channa maculata and the quality of fry are improved, and the feed has very important significance for improving the aquatic product efficiency of high-quality fry of channa maculata in aquaculture.

The present invention provides a nutritional composition comprising milk phospholipids and egg phospholipids, particularly suitable as a nutritional composition for infants, also as a nutritional support product for pregnant women and as a nutritional supplement for the elderly, in which phosphatidylcholine and sphingomyelin and hence choline are also highly correlated. The invention provides a nutritional composition containing choline with high bioavailability.

The application provides a nanoemulsion and a preparation method and application thereof. The total amount of raw materials for preparing the nanoemulsion is 100%, and the raw materials include the following components: 1-40% of a composite surfactant, 1-25% of an oil phase, 1-30% of a co-surfactant, and the balance of a water phase; wherein the mass of the composite surfactant is 100%, and the composite surfactant includes the following components: 5-25% of a biological surfactant, 35-65% of a fatty alcohol polyoxyethylene ether surfactant, 1-20% of dodecyl benzene sulfonic acid and / or sodium salt thereof, 1-20% of oleic acid, and 1-5% of citric acid; the biological surfactant includes one or more than two combinations of sophorolipid, rhamnolipid, trehalose lipid, surfactin, alkyl polyglycoside, phosphatidylcholine, amino acid lipid, saponin, phospholipid, or derivatives thereof; and the average particle size of the emulsion droplets in the nanoemulsion is 1.5-5 nm. The nanoemulsion has excellent recovery performance.

This invention discloses a soothing and repairing composition and its application, comprising the following raw materials: phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, tocopherol, ceramide NP, triethanolamine, lactobacillus, macadamia seed oil, magnolia alcohol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, inulin root juice, arginine / lysine polypeptide, squalane, jojoba seed oil, scutellaria baicalensis root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylate / C10-30 alkanol acrylate crosspolymer, α-glucan oligosaccharide, 1,2-hexanediol, and water as the balance. Compared with the prior art, the soothing and repairing composition prepared by this invention has the effects of rapidly rebuilding the skin barrier, regulating skin immune function, improving skin microecology, synergistic effect, and rapid skin repair.

The invention discloses a cell membrane vesicle self-assembly body loaded with spirulina PDRN and a preparation method of the cell membrane vesicle self-assembly body, and belongs to the technical field of cosmetics. The preparation method comprises the following steps: homogenizing and crushing spirulina at low temperature and high pressure, and performing graded filtration to prepare spirulina vesicle suspension; mixing with auxiliary materials such as spirulina platensis source PDRN, hydrogenated soybean phosphatidylcholine and the like to prepare a medicine-carrying vesicle premixed solution; and carrying out pre-homogenization, low-temperature fine homogenization and graded filtration to obtain the target self-assembly body. According to the invention, the spirulina natural cell membrane vesicles are taken as a core carrier, efficient encapsulation of PDRN is realized through membrane fusion recombination, the encapsulation efficiency of the obtained product can reach 55% or more, the transdermal absorption performance is excellent, UVB-induced skin light injury cells can be remarkably repaired, and the product has the effects of resisting aging, tightening, resisting wrinkles and whitening, and can be widely applied to preparation of skin care products.

The invention provides powdery phospholipid with good free-running property and rich phosphatidylcholine as well as a preparation method and application of the powdery phospholipid, and belongs to the technical field of deep processing of phospholipid. According to the method, the crude phospholipid is sequentially subjected to absolute ethyl alcohol purification and acetone refining, the refining frequency is controlled, it is guaranteed that the PC content is 40 wt% or above, meanwhile, the isomaltitol is added in the last time of refining, and the isomaltitol serves as sugar alcohol which is low in hygroscopicity and easy to crystallize, so that the purity of the product is greatly improved. At the moment, a special co-dispersion system which can form with phospholipid in an acetone medium is added, and in the subsequent drying process, the phospholipid particles can be accurately filled and an isolation layer is formed, so that the physical structure of the product is fundamentally changed, and particle adhesion is prevented from internal anti-caking and internal isomaltitol is used as a skeleton; an anti-caking agent is arranged outside to serve as a'ball 'to further reduce friction, and the dual-action mechanism ensures that the final product has extremely excellent flowability and long-term storage stability.

The invention provides a phospholipid composition and an edible oil anhydrous degumming method. The phospholipid composition is separated from cakes or residues obtained by squeezing oil materials to prepare oil, the mass of phospholipid accounts for 70-100% of the total mass of the phospholipid composition, and the mass of phosphatidylcholine accounts for 25% or below of the total mass of the phospholipid composition. According to the degumming method, the phospholipid composition is used for degumming. By using the degumming method disclosed by the invention, the phosphorus content in the edible oil can be reduced, and the flavor is not influenced.

The application belongs to the technical field of cosmetics, and discloses an enzyme moisturizing composition, a preparation method and application thereof, and aims to solve the problem that the existing enzyme-containing mask is limited in enzyme efficacy due to skin residual grease blocking. The enzyme moisturizing composition comprises a yeast / rice fermentation product filtrate, an amphiphilic compound (consisting of phosphatidylcholine, PEG-10 stearate and lipase), sodium hyaluronate and the like; the mask has a face a and a face b, the face a is coated with the enzyme moisturizing composition, and the face b is coated with a supplementary moisturizing composition containing trehalose; step-by-step drying is adopted in the mask preparation, and the water content of each face of the mask is controlled to be 20-25%. The application can break through the grease blocking, fully exert the moisturizing and repairing efficacy of the yeast / rice fermentation product filtrate, and the mask is stable and has good skin feel.

The invention relates to the technical field of ultraviolet light analysis, and particularly discloses a qualitative and quantitative method of phosphatidylcholine, which is used for solving the problems that phosphatidylcholine multi-carbon-chain components are difficult to stably separate, retention drift is caused by different batches of mobile phase A solvent strength and selectivity fluctuation, integral mismatch is caused by acromion and co-elution, and the stability of the components is poor. Different carbon chain reference substances are difficult to prepare, so that qualitative and quantitative deviation is caused. The method comprises the following steps: preparing a test solution, performing HPLC gradient separation and mobile phase A closed-loop calibration, performing marker time axis correction and acromion MS resolution quantification, and performing QTOF-MS molecular weight qualitative and qualitative and quantitative contrast output. A mobile phase A is calibrated in a closed-loop manner through a marker alpha to stabilize the strength and selectivity of a batch of solvents, correction is performed according to a marker time axis, an integral window is generated automatically, a UV area is split according to an acromion EIC proportion to inhibit misintegration caused by drifting and peak stacking, and qualitative and quantitative detection of a to-be-detected sample is achieved without using a whole set of multi-carbon-chain PC reference substances.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The invention relates to the technical field of anti-tumor bionic nanomaterials, and discloses a preparation method and application of tumor-bacterial membrane chimeric nanoparticles, and the preparation method comprises the following steps: carrying out rotary evaporation on dimyristoyl phosphatidylcholine and cholesterol oleate to obtain an HDL rotary evaporation film; mixing the tumor cell membrane with the bacterial membrane to obtain a tumor-bacterial mixed membrane; pre-mixing apolipoprotein ApoA-1 with the tumor-bacteria mixed membrane, and adding the mixed solution into a container containing an HDL rotary evaporation membrane for hydration and reconstruction to obtain a crude suspension; and carrying out ultrafiltration purification on the crude suspension to obtain the tumor-bacterial membrane chimeric nanoparticles. The tumor cell membrane and the bacterial membrane are co-loaded on the high-density lipoprotein, so that the two membrane components can be co-delivered to the dendritic cells to induce maturation of the dendritic cells, are accumulated in tumors and drainage lymph nodes in vivo, activate CD8 + T cell response and have an inhibition effect on tumor growth.

The invention belongs to the technical field of skin care products, and provides an anti-skin-aging bovine-derived protein peptide composition and a preparation method thereof. The preparation method comprises the following steps: preparing bovine-derived protein peptide with the molecular weight of 300-800Da by adopting a sequential enzymolysis technology, directionally enriching active peptide fragments with arginine and lysine content of more than or equal to 18% through cation exchange chromatography, constructing an antioxidant synergistic network with ascorbyl sodium phosphate, tocopheryl acetate and phytic acid, preparing a bionic liposome carrier by utilizing phosphatidylcholine, cholesterol and ceramide 3, and preparing the bovine-derived protein peptide biomimetic liposome. The surface of a carrier is sequentially coated with a poly L-histidine layer, a hyaluronic acid layer and a polycaprolactone outer layer by adopting a multi-layer response coating design, and is grafted with hyaluronic acid oligosaccharide to form a stable multi-layer structure. The average particle size of the prepared composition is 120-280 nm, the drug loading efficiency is larger than or equal to 82%, the 24-hour cumulative release rate is 58-82%, and the composition shows excellent controlled release performance and anti-aging activity and is suitable for development and application of high-end anti-aging skin care products.

The invention relates to tricholoma matsutake endophytic fungus fermented oil with a whitening effect and a preparation method and application thereof. The preparation method comprises the following steps: (1) inoculating a tricholoma matsutake endophytic fungus seed solution into a fermentation culture medium for fermentation culture to obtain a primary fermentation solution; and (2) mixing the primary fermentation liquor with vegetable oil and a phosphatidylcholine-based eutectic solvent, continuing fermentation culture, and centrifugally collecting an upper-layer oil phase to obtain the tricholoma matsutake endophytic fungus fermentation oil. The tricholoma matsutake endophytic fungus fermentation oil prepared by the invention has high-level transdermal capabilities of oil-soluble functional components and water-soluble functional components, and has an excellent whitening effect.

This invention discloses a method for preparing a highly stable polydopamine-lipid bilayer membrane. On one side of a porous Teflon membrane scaffold, dopamine and polyethyleneimine self-polymerize at the interface of an alkaline buffer and air to form a porous polymer monolayer membrane. Simultaneously, on the other side, diaphytylphosphatidylcholine self-assembles at the solution / air interface to form a lipid monolayer membrane. A solution-lifting method is used to spontaneously fuse the Teflon pores to form a polymer / lipid bilayer composite membrane. This asymmetric composite membrane exhibits excellent mechanical strength, stability, and high sealing performance. Membrane proteins, protein channels, or protein nanopores can spontaneously and rapidly insert into the composite membrane to form channels, enabling single-molecule pA-level current or optical measurements. Furthermore, protein biomolecules such as enzymes, antigens, or antibodies can be sandwiched and sealed between the composite membranes, utilizing spatial effects to achieve label-free single-molecule detection.

The present application discloses PLPC-DB, an ultrapurified phospholipoproteomic composition derived from the supernatant of peripheral blood mononuclear cells (PBMCs). It comprises essential phospholipids, bioactive proteins, regulatory peptides, and intercellular signaling factors. The composition exceeds 99% purity through a multi-stage purification process combining high-speed centrifugation and selective ultrafiltration (1-50 kDa), followed by lyophilization. This process ensures structural stability for ≥24 months and inter-batch variability <2%. PLPC-DB supports reproducibility and molecular integrity in research and diagnostic settings. Key components include phosphatidylcholine and phosphatidylserine for membrane stabilization and intracellular signaling; structural and regulatory lipids for membrane biogenesis and immune-relevant components involved in antigen presentation, cytokine modulation, and membrane-associated signaling. These may include structurally defined molecules compatible with immunological evaluation in experimental and non-therapeutic settings. The composition is formulated for bioaccessible delivery via sublingual, endonasal, transdermal, and injectable routes, and is intended exclusively for non-therapeutic use in experimental and translational models.

The invention relates to the technical field of sterilization and antifogging, in particular to a microsphere-based antibacterial and antifogging additive, a preparation method thereof, a multifunctional coating and application. The microsphere-based antibacterial and antifogging additive is a liposome vesicle microsphere, and the liposome vesicle microsphere is prepared from an oil-phase raw material and a water-phase raw material; the oil phase raw material comprises one or more of distearoyl phosphatidylcholine, hydrogenated lecithin and cholesterol; the water-phase raw material is a mixture of polyhexamethylene biguanide, polyethyleneimine and benzalkonium chloride; in the water phase raw material, the content of the polyhexamethylene biguanide is 25wt%-45wt%. By optimizing the formula of the microspheres, the efficiency and effect of killing nucleic acid can be remarkably improved, and the fog-resistant and anti-fog effects are achieved.

Disclosed is a sustained-release formulation of semaglutide. The sustained-release formulation of semaglutide comprises semaglutide or a pharmaceutically acceptable salt thereof, triacylglycerol, phosphatidylcholine, absolute ethanol, a solubilizer, and a pH regulator.

The invention relates to the technical field of feed additives, and provides a feed additive which is composed of an organic trace element group, a medicinal and edible plant group, a functional nutrition group and a compound vitamin group according to specific parts by weight, wherein the organic trace element group comprises 550-650 g of organic selenium, 250-350 g of zinc methionine and 150-250 g of glycine iron; the medicinal and edible plant group comprises 35-45 kg of astragalus membranaceus powder, 25-35 kg of Chinese wolfberry fruit powder and 20-30 kg of Chinese yam powder; and the functional nutrition group comprises 45-65kg of spirulina powder of 100-200 meshes and 1.0-1.5 kg of soybean lecithin with the phosphatidylcholine content of more than or equal to 20%. Medicinal and edible plants and organic trace elements are combined, risk raw materials such as inorganic selenium are abandoned, and scientific synergistic matching is combined, so that the selenium content and the calcium content of egg products are stably increased, heavy metal and antibiotic residues are not detected, the cholesterol content is remarkably reduced, and the egg products completely meet the food safety standard; the core problems that a traditional additive is insufficient in safety and unstable in nutrition enrichment are solved.

The invention discloses an internal pressure type polyether sulfone hollow fiber ultrafiltration membrane as well as a preparation method and application thereof. The internal pressure type polyethersulfone hollow fiber ultrafiltration membrane is provided with multistage pore channels; the inner surface of the internal pressure type polyethersulfone hollow fiber ultrafiltration membrane is modified by a natural phenolic compound, and the outer surface and pore channel walls are modified by soybean phosphatidylcholine. The internal pressure type polyether sulfone hollow fiber ultrafiltration membrane provided by the invention has ultrahigh water flux and excellent anti-pollution performance, and is especially suitable for high-risk pollution scenes such as reclaimed water deep treatment and the like.

The invention relates to the use of empty liposomes of defined lipid composition or mixtures of empty liposomes of defined lipid composition and to the use of other lipid bilayers or monolayers of defined lipid composition for the treatment and prevention of bacterial infections. It has been found that such liposomes, in particular a two- and a four-component mixture of liposomes comprising cholesterol and sphingomyelin, liposomes consisting of sphingomyelin, liposomes comprising sphingomyelin and phosphatidylcholine, and liposomes comprising cholesterol and phosphatidylcholine efficiently sequestrate a variety of toxins secreted by bacteria, thus preventing binding of bacterial toxins to target cells and toxin-induced lysis of the target cells. Injected intravenously, liposome mixtures prevented death of laboratory mice infected with lethal doses of Staphylococcus aureus or Streptococcus pneumoniae.

The invention provides a liposome composition with stable stomach and a preparation method thereof. The lipidosome composition comprises 1-40 parts by weight of phospholipid, 0.5-18 parts by weight of protein, 0.5-18 parts by weight of edible gum, 0.1-30 parts by weight of functional components and 8-70 parts by weight of water, the phosphatidylcholine content of the phospholipid is 15-70%, the edible gum is one or two of xanthan gum and gellan gum, and the functional components are one or two of functional components and water. The protein is one or more of whey protein isolate, whey protein concentrate, soy protein isolate, casein, oat protein, lactoferrin and pea protein isolate. The lipidosome successfully solves the problem that a lipidosome system containing nutritional ingredients and protein precipitates in the gastrointestinal tract environment, and the micelle conversion rate can be increased.

Provided are a sustained-release preparation and a preparation method therefor. The sustained-release preparation comprises a pharmaceutically active ingredient, triacylglycerol, phosphatidylcholine, a solvent, a solubilizer, and a pH regulator. The preparation method comprises: thoroughly mixing the pharmaceutically active ingredient, triacylglycerol, phosphatidylcholine, the solvent, the solubilizer, and the pH regulator.

The invention relates to the technical field of pharmaceutical preparations, and discloses a doxorubicin and cyclophosphamide liposome compound injection which is prepared from doxorubicin hydrochloride, cyclophosphamide, hydrogenated soybean phosphatidylcholine, cholesterol, polyethylene glycol derivative phospholipid, anhydrous magnesium sulfate, L-arginine and a sucrose octasulfate ammonium solution. Magnesium ions introduced into an inner water phase participate in competitive binding, doxorubicin and sucrose octasulfate are induced to form a loose co-precipitation structure with lattice defects, hydrophilic cyclophosphamide is physically filled and cured by using micro gaps, and efficient encapsulation of non-gradient dependent drugs is realized. Meanwhile, an in-situ pH buffer system is constructed by using L-arginine, protons generated in a drug loading process are neutralized, an internal water phase is maintained in a neutral environment, and acid-catalyzed hydrolysis of cyclophosphamide is effectively inhibited. According to the invention, the double-drug encapsulation efficiency and storage stability of the compound liposome are obviously improved.

The invention belongs to the technical field of biological medicines, and discloses an anti-skin aging composition containing ginseng plant cell exosomes and a preparation method thereof. The composition comprises a purified ginseng plant cell exosome, a pH response type anionic polyelectrolyte, a phosphatidylcholine and cholesterol mixture, a polyol humectant and deionized water, wherein the pH response polymer forms a dynamic charge shielding layer under a storage condition to prevent aggregation, and the active exosome is rapidly dissociated and released under a slightly acid skin environment. According to the invention, the defect that the exosome in the existing water-based matrix is inactivated due to charge interference is fundamentally overcome, meanwhile, an organic solvent, a surfactant or a complex nano-carrier does not need to be introduced, and the conciseness and safety of the formula are kept. The composition is suitable for essence, emulsion, face cream and other dosage forms, can be widely applied to anti-wrinkle, tightening, brightening and other functional skin care products, and has remarkable industrialization prospects and clinical application value.

The invention belongs to the technical field of medical materials, and particularly relates to a phosphatidylserine modified EGCG liposome, a preparation method and application of the phosphatidylserine modified EGCG liposome in bone infection resistance. The epigallocatechin gallate is entrapped in the liposome, a lipid bilayer of the epigallocatechin gallate comprises phosphatidylserine, phosphatidylcholine and cholesterol, and the molar ratio of the phosphatidylserine to the phosphatidylcholine to the cholesterol is controlled to be (1-2): 2: 1. The PS-EGCG liposome is prepared based on a film hydration method, the process is simple and convenient, and the obtained liposome is uniform in particle size, good in dispersity and stable in Zeta potential, can be effectively ingested by macrophages, plays the functions of inhibiting bacterial proliferation and regulating immune response, and is expected to be applied to treatment of infectious bone defects.

The invention relates to the technical field of medical materials, and particularly discloses a non-absorbable suture with excellent biocompatibility and a preparation method of the non-absorbable suture. The non-absorbent suture provided by the invention comprises a core layer, a transition layer and a surface functional layer, the core layer and the transition layer are interwoven and fixed through electrostatic spinning, and the surface functional layer is fixed on the surface of the transition layer through vapor deposition polymerization; the diameter of the core layer is 20-50 microns, and the porosity of the core layer is less than 5%; the transition layer is made of polyether-ether-ketone of which the mesh aperture is 10-15 microns and the thickness is 5-10 microns; the surface functional layer is a zwitterionic polymer covalently grafted with phosphorylcholine, and the thickness of the zwitterionic polymer is 0.5-1.2 [mu] m; the invention further provides a preparation method of the non-absorbent suture. The non-absorbable suture has the advantages of being good in biocompatibility, good in long-term mechanical stability and the like, and is suitable for medical suture scenes needing lasting support.

The invention particularly relates to a cabozantinib and osimertinib co-loaded targeting liposome and application thereof in overcoming EGFR-TKI drug resistance, and belongs to the technical field of biological medicine. The co-drug-loaded targeting liposome disclosed by the invention is coated with osimertinib and cabozantinib at the same time, and a GE11 peptide targeting ligand is connected to a membrane material of the co-drug-loaded targeting liposome; wherein the mass ratio of osimertinib to cabozantinib is 1: (0.5-2), preferably 1: 1; the membrane material comprises hydrogenated soybean phosphatidylcholine, cholesterol and DSPE-PEG2000, and the mass ratio of the hydrogenated soybean phosphatidylcholine to the cholesterol to the DSPE-PEG2000 is (2.5-3.5): 1: 1. According to the co-drug-loading targeting liposome disclosed by the invention, a drug can be synergistically delivered to a tumor site through active targeting mediated by GE11 peptide, an EGFR main pathway and key drug-resistant bypasses such as MET are efficiently inhibited, and the co-drug-loading targeting liposome shows a remarkable synergistic interaction effect in the aspect of reversing acquired drug resistance of osimertinib.