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705 results about "Phosphatidylcholine" patented technology
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Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using hexane. They are also a member of the lecithin group of yellow-brownish fatty substances occurring in animal and plant tissues. Dipalmitoyl phosphatidylcholine (a.k.a. lecithin) is a major component of pulmonary surfactant and is often used in the L/S ratio to calculate fetal lung maturity. While phosphatidylcholines are found in all plant and animal cells, they are absent in the membranes of most bacteria, including Escherichia coli. Purified phosphatidylcholine is produced commercially.
Methods of delivering stable topical drug compositions
InactiveUS20060127469A1Easy and administration routeNot to wasteOrganic active ingredientsPeptide/protein ingredientsRoom temperatureTopical drug
A method of delivering a drug composition comprises providing a carrier having a phosphatidylcholine component and a drug entrapped therein, and applying the composition to the skin for transdermal delivery of the drug, wherein the composition is stable at room temperature.
Owner:TRANSDERMAL BIOTECHNOLOGY INC
Biodegradable biocompatible implant and method of manufacturing same
InactiveUS20050208122A1Reduce dosing frequencyEliminate side effectsBiocidePharmaceutical non-active ingredientsLipid formationActive agent
Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel, paste, solution, film, implant or barrier depending on the intended application. The polymer component of the matrix is the naturally occurring biomaterial, chitosan, or a mixture of chitin and chitosan. The lipid component may include phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidyl or a mixture thereof. The delivery system may be used for delivery of hydrophilic agents, hydrophobic agents or combinations thereof. The therapeutically active agents may be formulated within the matrix as free agents or incorporated into particles. In a preferred embodiment the agents are incorporated into polymeric particles that are dispersed throughout the matrix.
Owner:ALLEN +2
Topically applied Glucosamine Sulfate and all its related, precursor, and derivative compounds significantly increases the skin's natural produciton of hyaluronic acid for the rejuvenation of healthier younger-looking skin; while PhosphatidylCholine is required to replace its deficiency caused by topical Dimethylaminoethanol (DMAE)
InactiveUS20070092469A1Reducing eczemaReducing psoriasisBiocideCosmetic preparationsWrinkle skinPhysiology
A topical skin rejuvenation preparation to relieve wrinkles, increase the skin's natural production of hyaluronic acid, reverse the lack of suppleness, hydrate from within, erase spider veins, reduce varicose veins, lighten aging dark blotches (“liver spots” / Lentigos, Senile Lentigines), decrease acne, and reduce under eye puffiness includes Glucosamine (2-amino-2-deoxy-alpha-D-glucose), a hexosamine (6 carbon amino sugar), including its derivative and precursor compounds: Glucosamine Sulfate, Glucosamine Hydrochloride, Glucose-6-Phosphate, Acetyl Glucosamine, Fructose-6-phosphate, Glucosamine-6-Phosphate, to increase production of Hyaluronic acid and collagen from Glucosamine Sulfate, its precursors and derivatives and to increase skin muscle tone by Dimethylaminoethanol (DMAE) while over coming deficiency it creates in each cell's production of PhosphatidylCholine, whose deficiency damages cell membranes, as well as mitochondrial and lysosome membranes.
Owner:JACOBS ERIC
Methods for formulating stabilized insulin compositions
A method of formulating insulin compositions comprises preparing a carrier having a phosphatidylcholine component which entraps insulin, stabilizing insulin compositions at room temperatures.
Owner:TRANSDERMAL BIOTECHNOLOGY INC
Topical drug delivery using phosphatidylcholine
InactiveUS20060105955A1Topical deliveryEasier and pleasanterOrganic active ingredientsPeptide/protein ingredientsTopical drugTransdermal medication
The present invention relates to compositions and methods for transdermal drug delivery comprising formulating a phosphatidylcholine carrier composition containing the drug and applying the composition to the skin.
Owner:TRANSDERMAL BIOTECHNOLOGY INC
Topical skin treatment composition
InactiveUS20100311696A1Easy and administration routeNot to wasteBiocidePeptide/protein ingredientsSkin treatmentsDermatology
The present invention relates to compositions and methods for transdermal drug delivery comprising formulating a phosphatidylcholine carrier composition containing the drug and applying the composition to the skin. The present invention further relates to the topical application to the skin of such compositions, and / or preparations containing them, for the prevention and / or treatment of damage to skin.
Owner:PERRICONE NICHOLAS V
Methods and compositions for the non-surgical removal of fat
ActiveUS7622130B2Easy to disassembleReduces blood lossOrganic active ingredientsCosmetic preparationsSurgical removalCellulite
Compositions and methods useful in the non-surgical removal of localized fat deposits in patients in need thereof using pharmacologically active detergents are disclosed. The pharmacologically active detergent compositions can additionally include anti-inflammatory agents, analgesics, dispersion agents and pharmaceutically acceptable excipients but do not contain phosphotidylcholine. The pharmacologically active detergent compositions are useful for treating localized accumulations of fat including lower eyelid fat herniation, lipodystrophy and fat deposits associated with cellulite and do not require surgical procedures such as liposuction.
Owner:RGT UNIV OF CALIFORNIA +1
Lipid bilayer carrier for drugs or imaging agents
InactiveUS20130108551A1Better addressMaximize MR contrast enhancementOrganic active ingredientsDispersion deliveryChain lengthImaging agent
Disclosed are carriers for drugs and / or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long / short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Immune modulation using peptides and other compositions
The present invention generally relates to compositions and methods for topical or transdermal delivery for immune modulation. In some cases, the composition may include nitric oxide and / or peptides. The nitric oxide and / or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
Owner:TRANSDERMAL BIOTECHNOLOGY INC
Wound healing using topical systems and methods
ActiveUS9295636B2Promote wound healingInorganic active ingredientsOintment deliveryWound healingNitric oxide
The present invention generally relates to compositions and methods for topical or transdermal delivery and treatment of wounds and / or promoting wound healing. In some cases, the composition may include nitric oxide and / or peptides. The nitric oxide and / or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., wounded skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
Owner:TRANSDERMAL BIOTECHNOLOGY INC
Emollient lotion for moisturizing skin and controlling oil and preparation method of emollient lotion
InactiveCN103565673AReduce potential irritationGood anti-inflammatory effectCosmetic preparationsToilet preparationsPreservativeDistilled water
The invention discloses an emollient lotion for moisturizing skin and controlling oil. The emollient lotion is prepared from the following components in percentage by mass: 0.1-5% of hydrogenated phosphatidylcholine, 0.1-5% of phytosterol, 0.001-1% of ceramide, 0.1-5% of silica, 2-20% of humectant, 2-20% of grease, 0.1-1% of thickening agent, 0.5-5% of emulsifying agent, 0.1-0.6% of preservative and the balance of distilled water. The emollient lotion has efficient moisture retention and can be used for enhancing the protection mechanism of the skin, promoting the metabolism of cell membranes of the skin and achieving the aims of improving dry skin as well as relieving and repairing the skin.
Owner:广州品赫化妆品有限公司
Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location with acne, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
Owner:TRANSDERMAL BIOTECHNOLOGY INC
Compositions for enhanced epithelial permeation of peptide yy for treating obesity
InactiveUS20070275893A1Promote absorptionImprove bioavailabilityBiocideOrganic active ingredientsPYY PeptidePYY receptors
Pharmaceutical compositions comprising PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the PYY(3-36) is present in an amount effective to alleviate one or more symptom(s) of obesity in a subject, and the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation.
Owner:NASTECH PHARMA
Human embryo kidney 293 cell amplifying protein-free medium
The invention relates to a culture medium and the usage thereof, which particularly relates to a human embryonic kidney 293 cell amplification culture medium and the usage thereof. The invention pertains to the field of biological products. The human embryonic kidney 293 cell amplification protein-free culture medium includes a basic culture medium and further includes a phosphatidylcholine and trace elements. The human embryonic kidney 293 cell protein-free culture medium does not contain any animal serum or protein, and consists of amino acids, vitamins, inorganic salts, sugars, phosphatidyl choline and trace elements. The human embryonic kidney 293 cell serum-free culture medium can directly replace the conventional culture medium which contains serum, and the human embryonic kidney 293 cell does not need an adaptation process.
Owner:天津百若克医药生物技术有限责任公司
Liquid-filled cartridge for electronic device that produces an aerosol for inhalation by a person
A disposable cartridge is disclosed for use with an electronic device for producing an aerosol for inhalation by a person. The cartridge comprises a liquid container containing a liquid which when aerosolized is intended for inhalation by a person; and a transducer that, when actuated, causes the liquid from the container to be aerosolized such that the aerosol may be inhaled by a person. In various embodiments, the liquid comprises: a liposomal carrier; a liquid mixture having an active agent entrapped by liposomes; and a liquid mixture comprising a nanodispersion. The liquid may include nicotine, tetrahydrocannabinol, cannabidiol, or nanoparticles formed by an oil droplet covered by a monolayer of phosphatidylcholine. The transducer preferably comprises a mesh material with the transducer and the mesh material forming a piezo mesh disk for aerosolizing the liquid.
Owner:QNOVIA INC
Injectable phosphatidylcholine preparations
InactiveUS20060222673A1Reduce and remove localized fatLower Level RequirementsOrganic active ingredientsCosmetic preparationsFat padPhosphatidylcholine
The present invention relates to viscous injectable phosphatidylcholine preparations and their use for the reduction or removal of localized adipose tissue (fat) deposits, and to intra-fat pad injection and implant methods of administering such preparations for the non-surgical removal or reduction of localized fatty deposits.
Owner:AVENTIS PHARMA INC
Process of extracting phosphatidylcholine from soybean phosphatide
The extraction process of phosphatidylcholine from soybean phosphatide includes multistage countercurrent extraction of soybean phosphatide with double-liquid phase mixed solvent comprising saturated alkane, acetonitrile and low carbon alcohol and the vacuum exsolution of ultimate extracted liquid to obtain the product with phosphatidylcholine content over 80 % in the yield over 80 %. The said technological process is simple, less investment in the apparatus, and suitable for continuous and automatic industrial production.
Owner:RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
Dietetic food composition for losing weight
ActiveCN103719852AControl intakeControl ingredientSugar food ingredientsFood ingredient functionsBiotechnologyVegetable oil
The invention discloses a dietetic food composition for losing weight. The composition comprises the following ingredients: fresh meat and aquatic product, vegetables, fruits, dried mushroom products, cereals, beans, nut meat, edible vegetable oil, eggs, protein hydrolysate powder, dietary fiber powder, konjac powder, guar gum, polyols, phosphatidylcholine, fruit polyphenols, L-carnitine, vitamin A, vitamin E, vitamin C, thiamine hydrochloride, riboflavin, nicotinamide, pyridoxine hydrochloride, folic acid, cyanide-containing cobalt and pantothenic acid. By adopting the dietetic food composition disclosed by the invention, the total energy intake is reduced under the premise of ensuring normal basic metabolic rate, the requirements of the body on protein at a low-energy diet period are improved, and related nutrients are replenished to facilitate body fat, visceral fat and blood lipid metabolism, so as to achieve the target of losing weight. Meanwhile, the invention also discloses a preparation method of the dietetic food composition and use of the dietetic food composition in preparation of a medicament for preventing or treating an obesity disease.
Owner:GUANGZHOU CINJEP BIOTECH
Amphoteric liposomes
ActiveUS20110076322A1Improve stabilityIncrease serum stabilityOrganic active ingredientsBiocideAmphiphileSerum ige
A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug / lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
Owner:BIONTECH DELIVERY TECH GMBH
Process for extracting phosphatidecholine from powdered soybean phosphatide
A process for extracting phosphatidylcholine from the powdered soybean phosphatide incldues multi-stage counter-current extracting with the mixed solvent of acetonitrile and low-carbon alcohol, and vacuum removing of solvent. Its advantages are high purity (more than 70%), and high output rate (more than 70%).
Owner:TSINGHUA UNIV
Method for preparing phosphatidylserine and phosphatidylcholine
ActiveCN102964379ASimple extraction methodLow costPhosphatide foodstuff compositionsBiotechnologyDietary supplement
The invention relates to a method for preparing phosphatidylserine and phosphatidylcholine, and belongs to the field of food health-care products. The method comprises the following steps of: extracting soybean meal phospholipid which is used as a raw material by an organic solvent, and then distilling and drying to respectively obtain a phosphatidylcholine crude product and a phosphatidylserine crude product; and separating and purifying the phosphatidylcholine crude product and the phosphatidylserine crude product through a silica gel column of 200-300 meshes, eluting with a mixed organic solvent, concentrating the eluant, and drying to obtain phosphatidylserine and phosphatidylcholine. According to the method, the purities of the phosphatidylserine and the phosphatidylcholine meet requirements of new resource foods, so that the phosphatidylserine and the phosphatidylcholine can be used as new resource dietary supplements and have high economic added values; and the phosphatidylserine and the phosphatidylcholine are prepared at the same time by effectively combining simple extraction of the phosphatidylserine and the simple extraction of the phosphatidylcholine. By the method, the production time is shortened, the production cost is reduced, the production rate is improved, the operation is simple, and the products have safety.
Owner:成都圆大生物科技有限公司
Liposome oxaliplatin compositions for cancer therapy
The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-70 mol % of a phosphatidylcholine lipid, 25-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and oxaliplatin. Oxaliplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the oxaliplatin weight is from about 20:1 to about 65:1. Methods for the preparation of liposomal oxaliplatin and the treatment of cancer are also disclosed.
Owner:MALLINCKRODT INC
Method for finishing fabric through plant essential oil thermosensitive liposomes
The invention discloses a method for finishing fabric through plant essential oil thermosensitive liposomes. The method comprises the following steps: mixing and stirring tea tree essential oil, menthol and artemisia vulgaris oil to obtain a natural fragrant antibacterial agent; dissolving the natural fragrant antibacterial agent in a phosphate buffered solution; mixing natural phosphatide, phosphatidylcholine, glyceryl phosphatide, phosphatidyl ethanolamine, phosphatidylserine and phosphatidic acid, adding cholesterol, dissolving the mixture into chloroform, pouring into a container, and evaporating at the room temperature until a layer of uniform thin film is formed on the container wall; adding the phosphate buffered solution of the natural fragrant antibacterial agent into the container coated with the thin film in ultrasonic water bath, and performing ultrasonic oscillation to obtain a thermosensitive liposome suspension liquor; adding an adhesive into the thermosensitive liposome suspension liquor, and stirring at the room temperature until the adhesive agent is completely dissolved, so as to obtain a thermosensitive fragrant antibacterial finishing agent; immersing and rolling fabric into the finishing liquid, immersing and rolling for the second time, and finally finishing and shaping the fabric by adopting a freezing and drying method.
Owner:新诚达时装(安徽)有限公司
Adsorption method for preparing soybean lecithin
InactiveCN102146094AHigh adsorption selectivityAdsorption will notPhosphatide foodstuff compositionsAlcoholSeparation technology
The invention relates to an adsorption method for preparing soybean lecithin. Granulesten is taken as a raw material, C1-C4 alcohol is taken as a solvent, an adsorbent is added, the mixture is stirred, adsorbed and filtered, filtrate is subjected to desolvation under reduced pressure and vacuum drying to form a soybean lecithin product with over 80 percent of phosphatidylcholine, and the yield is over 85 percent. Compared with the conventional preparation method, the direct adsorptive separation technology has the advantages of simple process, short production period, high product purity, low consumption of solvent, simple equipment, low investment cost and the like, and is suitable for large-scale industrial production.
Owner:NANJING TECH UNIV
Solid preparation of sodium aspirin and sodium pravastatin medicinal composition
InactiveCN102204920AGood effectOvercome deficienciesPill deliveryEster active ingredientsAspirinLiposome
Owner:HAINAN YONGTIAN PHARMA INST
Compositions containing phosphatidylcholine and essential fatty acids
The invention discloses pharmaneutical compositions comprising a phospholipid formulation that is fluidized with an oil composition containing a pre-determined ratio of omega 6 and omega 3 fatty acids. In particular the invention discloses phosphatidylcholine compositions that are fluidized with a pre-determined ratio of linoleic acid and alpha linolenic acid.
Owner:BODYBIO INC
Method for preparing lecithin in high purity
A process for preparing the high-purity phosphatidylcholine from vegetative phosphatide includes extracting, separating alcohol-soluble components, vacuum centrifugal concentrating, adding it to chromatographic Al2O3 column, eluting with the mixture of water and low-carbon alcohol, vacuum concentrating and drying. Its advantages are high purity and quality, high output rate and no poison and pollution.
Owner:HENAN UNIVERSITY OF TECHNOLOGY
Special diluent for swine mycoplasmal pneumonia vaccines and preparation method of special diluent
ActiveCN103071151AStrengthen cellsEnhance humoral immune stimulationAntibacterial agentsBacterial antigen ingredientsCholesterolVaccine antigen
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Metabonomics-based early diagnosis marker for chronic obstructive pulmonary disease and application thereof
InactiveCN111289736AExpand clinical applicationHigh promotional valueComponent separationDisease diagnosisDihydrouracilDimethylaniline N-oxide
The invention discloses a metabonomics-based diagnosis marker for chronic obstructive pulmonary disease and application thereof. The diagnosis marker comprises the following 28 blood plasma metabolismmarkers: phosphatidylcholine PC 16:1-36:3, phosphatidylcholine PC 26:0-22:4, phosphatidylcholine PC 26:0-22:3, phosphatidylcholine PC 47:5e, phosphatidylcholine PC 44:11e, phosphatidylcholine PC 16:0-24:5, phosphatidylcholine PC 20:2-20:3, phosphatidylcholine PC 40:10, phosphatidylcholine PC 38:9e, phosphatidylcholine PC 18:1-20:4, phosphatidylcholine PC 16:0-20:3, phenylacetaldehyde, dihydrouracil, nicotinamide, 4-methoxycinnamic acid, ketovaline, threonine, DL-3-aminoisobutyric acid, pyruvic acid, stachyose, caffeic acid, N, N-dimethylaniline, maltotriose, D(-)-gulonate-gamma-lactone, and L-asparaginase. The marker provided by the invention has good classification on metabolome data of patients suffering chronic obstructive pulmonary disease and healthy people, and can accurately distinguish the patients suffering chronic obstructive pulmonary disease from the healthy people.
Owner:PEKING UNIV +1
Extraction process of phosphatidylcholine with antarctic krill as source and preparation method of phosphatidylserine
InactiveCN103509047AReduce dosageEmission reductionPhosphatide foodstuff compositionsFermentationAlcoholFreeze-drying
The invention provides an extraction process of phosphatidylcholine with antarctic krill as a source. The extraction process comprises the following steps: collecting heads of the antarctic krill, adding water for decoction, stirring, sending the krill head decoction liquid to a cold pressing machine for solid-liquid separation, to obtain an oily liquid rich in phospholipid and krill heads and other solids; adding absolute ethyl alcohol into the krill heads and other solids, carrying out high shearing extraction, carrying out centrifugal separation, and concentrating to obtain an oily liquid; merging the oily liquids, drying under a reduced pressure, then filtering through a plate frame filter to remove insoluble substances, followed by carrying out membrane separation and concentration, carrying out column chromatography separation and purification, carrying out freeze drying, and thus obtaining the phosphatidylcholine product. The invention also provides a preparation method for phosphatidylserine with the antarctic krill as the source. The preparation method comprises the steps of hydrolyzing the extracted phosphatidylcholine by phospholipase D, and extracting to obtain phosphatidylserine rich in DHA and EPA. The extraction process and the preparation method are environmentally friendly, and are low in cost; and the obtained products have high content and good activity, and can be industrially produced.
Owner:ACERCHEM INT
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