A soothing repair efficacy composition and use thereof

Abstract

This invention discloses a soothing and repairing composition and its application, comprising the following raw materials: phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, tocopherol, ceramide NP, triethanolamine, lactobacillus, macadamia seed oil, magnolia alcohol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, inulin root juice, arginine / lysine polypeptide, squalane, jojoba seed oil, scutellaria baicalensis root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylate / C10-30 alkanol acrylate crosspolymer, α-glucan oligosaccharide, 1,2-hexanediol, and water as the balance. Compared with the prior art, the soothing and repairing composition prepared by this invention has the effects of rapidly rebuilding the skin barrier, regulating skin immune function, improving skin microecology, synergistic effect, and rapid skin repair.

Description

Technical Field

[0001] This invention relates to the field of skincare technology, and in particular to a soothing and repairing composition and its application. Background Technology

[0002] Due to various external and internal factors, people's skin becomes fragile and easily invaded by irritants, causing various uncomfortable reactions such as dryness, itching, stinging, redness, swelling, and aging. Common products with soothing and repairing effects mainly rely on adding various anti-allergic ingredients to block inflammation. Although they can temporarily eliminate itching and other discomforts, their mechanism is limited to relieving symptoms by inhibiting the release of inflammatory factors, resulting in a relatively simple pathway of action. Furthermore, these pharmacologically based products have limited repair and care effects on the skin, with insufficient transdermal penetration. They can only temporarily solve skin problems and cannot restore the skin to a healthy state by fundamentally regulating barrier function and microecological balance. Therefore, it is particularly important to develop a composition that can thoroughly cleanse the skin without damaging the skin barrier, while also providing repair and soothing effects.

[0003] Chinese patent application CN115177570A discloses a composition with soothing and repairing effects, its preparation method, and its application. The composition includes the following raw materials: peony root extract, kava leaf / root / stem extract, gentian extract, moringa seed extract, and butylene glycol. The composition obtained by this invention achieves significant anti-allergic, soothing, anti-aging, and skin-repairing effects through the interaction between its components. Furthermore, this composition requires no preservatives, effectively reducing the irritation of preservatives to human skin and significantly improving the safety of its use. However, the composition prepared by this invention has insufficient transdermal effect and cannot address skin health problems at their root. Summary of the Invention

[0004] In view of the shortcomings of existing soothing and repairing compositions, such as insufficient transdermal effect and inability to address the root cause of skin health issues, the technical problem to be solved by the present invention is to provide a soothing and repairing composition with good transdermal effect and long-lasting therapeutic effect, and its application.

[0005] To achieve the above-mentioned objectives, the present invention adopts the following technical solution:

[0006] A soothing and repairing composition comprising the following ingredients: phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, tocopherol, ceramide NP, triethanolamine, lactobacillus, macadamia seed oil, magnolol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, chicory root juice, arginine / lysine peptide, squalane, jojoba seed oil, scutellaria root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylates / C10-30 alkanol acrylate crosspolymer, α-glucan oligosaccharide, 1,2-hexanediol, and water as the balance.

[0007] Preferably, the composition with soothing and repairing effects comprises the following ingredients in percentage: 0.002-5% phytosterols, 0.01-2% chamomile extract, 0.05-2% hydrolyzed sodium hyaluronate, 0.003-3% tocopherol, 0.005-5% ceramide NP, 0.1-2% triethanolamine, 0.005-5% lactobacillus, 0.5-10% macadamia seed oil, 0.001-0.1% magnolol, 0.005-2% chamomile extract, 0.005-1% maltodextrin, 0.005-0.5% lecithin, 0.001-0.5% phosphatidylcholine, and ascorbic acid palmitate. Palmitate 0.005–0.5%, Ipomoea root juice 0.001–5%, arginine / lysine polypeptide 0.0001–5%, squalane 0.5–20%, jojoba seed oil 1–15%, Scutellaria baicalensis root extract 0.04–0.08%, Polygonum cuspidatum root extract 0.04–0.08%, fructose 0.01–1%, glycerol 0.1–8%, p-hydroxyacetophenone 0.1–1%, butylene glycol 0.5–10%, acrylates / C10-30 alkanol acrylate crosspolymer 0.1–2%, α-glucan oligosaccharide 0.05–5%, 1,2-hexanediol 0.1–1%, water balance to 100%.

[0008] A composition with soothing and repairing effects is prepared as follows:

[0009] Weigh each ingredient by weight percentage, including phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, triethanolamine, macadamia seed oil, magnolol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, inosinum root juice, squalane, jojoba seed oil, scutellaria root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylates / C10-30 alkanol acrylate crosspolymer, and α-glucan. Oligosaccharides, 1,2-hexanediol, and water are added to a mixing tank, heated to 60–80°C, maintained for 10–40 minutes, and then stirred for 10–40 minutes at a speed of 100–300 rpm. The mixture is then cooled to 5–20°C, and tocopherol, ceramide NP, lactobacillus, and arginine / lysine peptides are added. The mixture is then stirred at 100–300 rpm for 10–40 minutes, allowed to stand for 20–40 hours, filtered, and the filtrate is collected to obtain a composition with soothing and repairing effects.

[0010] Preferably, the composition with soothing and repairing effects comprises the following ingredients in percentage: 0.002-5% phytosterols, 0.01-2% chamomile extract, 0.05-2% hydrolyzed sodium hyaluronate, 0.003-3% tocopherol, 0.005-5% ceramide NP, 0.1-2% triethanolamine, 0.005-5% lactobacillus, 0.5-10% macadamia seed oil, 0.001-0.1% magnolol, 0.005-2% chamomile extract, 0.005-1% maltodextrin, 0.005-0.5% lecithin, 0.001-0.5% phosphatidylcholine, and 0.0% ascorbyl palmitate. 0.5-0.5%, Ipomoea root juice 0.001-5%, arginine / lysine polypeptide 0.0001-5%, squalane 0.5-20%, jojoba seed oil 1-15%, Scutellaria baicalensis root extract 0.04-0.08%, Polygonum cuspidatum root extract 0.04-0.08%, fructose 0.01-1%, glycerin 0.1-8%, p-hydroxyacetophenone 0.1-1%, butylene glycol 0.5-10%, acrylates / C10-30 alkanol acrylate crosspolymer 0.1-2%, α-glucan oligosaccharide 0.05-5%, 1,2-hexanediol 0.1-1%, complex transdermal penetration enhancer 1-5%, water balance to 100%.

[0011] Preferably, the composition with soothing and repairing effects is prepared by the following method:

[0012] Weigh each ingredient by weight percentage, including phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, triethanolamine, macadamia seed oil, magnolol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, inosinum root juice, squalane, jojoba seed oil, scutellaria root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylates / C10-30 alkanol acrylate crosspolymer, α-glucan oligosaccharides, and 1... Add 2-hexanediol and water to a mixing tank, heat to 60-80℃, maintain for 10-40 minutes, then stir for 10-40 minutes at a stirring speed of 100-300 rpm. Cool to 5-20℃, add tocopherol, ceramide NP, lactobacillus, arginine / lysine peptide, and a complex transdermal penetration enhancer, then stir at 100-300 rpm for 10-40 minutes. Let stand for 20-40 hours, filter, and collect the filtrate to obtain a composition with soothing and repairing effects.

[0013] Preferably, the phytosterols are at least one of β-sitosterol, stigmasterol, and campesterol.

[0014] Preferably, the butanediol is at least one of 1,2-butanediol, 1,3-butanediol, and 1,4-butanediol.

[0015] Preferably, the lactobacillus is Lactobacillus plantarum.

[0016] Phytosterols: have a soothing and repairing effect on the skin.

[0017] Chrysanthemum extract: has antioxidant and anti-inflammatory effects, which can relieve skin allergies and irritation.

[0018] Hydrolyzed sodium hyaluronate: a moisturizer that can improve the skin's ability to retain moisture.

[0019] Tocopherol (Vitamin E): An antioxidant that can protect against free radical damage and reduce skin inflammation and redness.

[0020] Ceramides: can enhance the skin barrier function and protect the skin from external stimuli.

[0021] Triethanolamine: Regulates skin pH and improves formula stability and transdermal absorption.

[0022] Lactobacillus: a probiotic that can regulate the skin's microecology and enhance its immunity.

[0023] Macadamia ulmoides seed oil: It has moisturizing and hydrating properties and can improve dry and rough skin.

[0024] Magnolioside: It has antioxidant and anti-inflammatory effects and can reduce skin allergies and irritation.

[0025] Chamomile extract: has anti-inflammatory and soothing properties, which can relieve skin allergies and redness.

[0026] Maltodextrin: a moisturizer that can improve the skin's ability to retain moisture.

[0027] Lecithin: It has moisturizing and hydrating properties and can improve dry and rough skin.

[0028] Phosphatidylcholine: It has moisturizing and hydrating effects and can improve dry and rough skin.

[0029] Ascorbyl palmitate: A stabilizer of vitamin C, it can protect against free radical damage and reduce skin inflammation and redness.

[0030] Chicory root juice: a moisturizer that can improve the skin's ability to retain moisture.

[0031] Arginine / Lysine peptides: have moisturizing and hydrating effects, and can improve dry and rough skin.

[0032] Squalane: A skin protectant that can strengthen the skin.

[0033] The transdermal penetration enhancer A is prepared as follows, in parts by weight:

[0034] Add 0.01–0.03 parts of chitosan to 30–50 parts of 0.5–2 wt% acetic acid aqueous solution, adjust the pH to 4.0–5.0 with 0.05–0.2 mol / L NaOH aqueous solution, stir at 100–300 rpm for 10–30 min, filter through a 100–500 mesh sieve to remove impurities, and obtain a chitosan mixture. Add 0.01–0.03 parts of crosslinking agent and 0.04–0.06 parts of farnesin to 40–60 parts of water, and add to the chitosan mixture while stirring at 100–300 rpm. Continue stirring for 40–80 min, then transfer to a centrifuge tube, add 40–60 parts of propylene carbonate, control the temperature at 10–30℃, centrifuge at 15000–25000 rpm for 10–30 min, collect the lower layer particles, wash with water, and dry at 10–25℃ for 5–30 h to obtain transdermal penetration promoter A.

[0035] Preferably, the crosslinking agent is sodium tripolyphosphate.

[0036] The transdermal penetration enhancer B is prepared as follows, in parts by weight:

[0037] 0.2–0.4 parts of ceramide NP, 0.2–0.4 parts of polypropylene glycol diglycidyl ether, and 0.05–0.2 parts of lecithin were added to 8–12 parts of dipropylene glycol at 70–95°C and stirred at 100–300 rpm for 0.5–2 h to obtain solution A. 0.4–0.6 parts of retinol were added to 4–6 parts of anhydrous ethanol to obtain solution B. Solution B was added to solution A, followed by 15–25 parts of water and 0.05–0.2 parts of sodium dodecyl sulfate, and stirred at 30 rpm for 5 min at room temperature to obtain transdermal penetration enhancer B.

[0038] The transdermal penetration enhancer C is prepared as follows, in parts by weight:

[0039] 0.3–0.4 parts coconut oil, 0.03–0.04 parts sorbitan monostearate, and 0.05–0.2 parts polycaprolactone were added to a mixed solvent consisting of 20–30 parts acetone and 1–3 parts anhydrous ethanol. Then, 0.001–0.003 parts phloretin were added to obtain an organic solution. The organic solution and 0.07–0.08 parts polysorbate 80 were then added to 40–60 parts water to obtain a suspension. The suspension was concentrated by evaporation under reduced pressure until the suspension was reduced to 5–15 parts, thus obtaining transdermal penetration enhancer C.

[0040] The preparation method of the composite transdermal penetration enhancer is as follows, in parts by weight:

[0041] Mix 0.5–2 parts of transdermal penetration enhancer A, 15–25 parts of transdermal penetration enhancer B, and 5–15 parts of transdermal penetration enhancer C and stir for 10–30 minutes at a stirring speed of 100–300 rpm. Then, evaporate and concentrate under reduced pressure to a volume of 1 / 1.5–3 of the original volume to obtain a composite transdermal penetration enhancer.

[0042] The present invention relates to the application of a soothing and repairing composition in the preparation of cosmetics, wherein the dosage form of the cosmetics includes any one of the following: aqueous solution, emulsion, cream, serum, mask, and spray.

[0043] This invention, by adding arginine / lysine peptides, can directly protect and activate mitochondria, promote ATP production, enhance cell activity, eliminate ROS, strengthen tight junction proteins and the skin's mechanical barrier, and tighten the skin. Simultaneously, it comprehensively inhibits inflammatory factors, reduces inflammation and redness, soothes sensitive skin, resists streptococcal invasion, repairs the skin barrier, and protects the balance of the skin's microbiome. Furthermore, imbalance of the skin's surface microecology is a significant factor leading to skin damage. By increasing beneficial bacteria (such as lactobacillus) and prebiotics (maltodextrin, inulin extract, α-glucan oligosaccharides), the number of beneficial bacteria can be rapidly increased, improving the skin's microecology, restoring skin health, and the soothing and repairing effects persist even after discontinuation of the medication. The novel sebum-like combination (ceramide NP, squalane, lecithin, phosphatidylcholine, phytosterols) can mimic the components of human sebum, rapidly repairing the skin barrier, reducing skin moisture loss, and promoting the repair of damaged skin; therefore, the skin shows good soothing and repairing effects after use, and these effects persist even after discontinuation of the medication.

[0044] This invention describes a transdermal penetration enhancer A obtained by modifying and grafting chitosan with sodium tripolyphosphate and farnesin. Transdermal penetration enhancer B is prepared by adding ceramide NP, polypropylene glycol diglycidyl ether, and lecithin to dipropylene glycol and stirring to obtain solution A, adding retinol to anhydrous ethanol to obtain solution B, adding solution B to solution A, and then adding water and sodium dodecyl sulfate and stirring. Transdermal penetration enhancer C is prepared by adding coconut oil, sorbitan monostearate, and polycaprolactone to a mixed solvent of acetone and ethanol, adding phloretin, and then adding polysorbate 80, followed by evaporation and concentration. The three transdermal penetration enhancers are mixed, evaporated, and concentrated to obtain a composite transdermal penetration enhancer. By inducing the molecular binding of ceramide NP with polypropylene glycol diglycidyl ether and lecithin, the crystallization of ceramide NP is successfully prevented. A stable system with excellent high-temperature and high-salinity resistance is constructed. Modifying the lecithin layer by binding hydrophobic molecules between ceramide NP and lecithin can enhance the transdermal performance of transdermal transdermal enhancer B. Phloretin is safe for use in cosmetics and also possesses anti-tumor activity. Transdermal transdermal enhancer C, prepared using phloretin, enhances the permeability of the stratum corneum and exhibits excellent penetration on the skin surface. Furthermore, the adhesion of transdermal transdermal enhancer C to the skin is also enhanced, prolonging the contact time between functional substances and skin tissue. Modified grafting of chitosan with sodium tripolyphosphate and farnesin prepares positively charged spherical nanoparticles with a smooth surface, possessing the ability to depolarize cell membranes to deliver functional ingredients into the skin, and is non-toxic to cells. The combination of these three substances facilitates synergistic effects, further promoting the transdermal performance of functional molecules, thereby improving the efficacy during use and post-discontinuation, and enhancing the skin feel.

[0045] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0046] 1) This invention adds arginine / lysine peptides, which can directly protect and activate the number of mitochondria, promote ATP production, enhance cell activity, eliminate ROS, strengthen tight junction proteins and skin mechanical barrier, tighten the skin, and at the same time comprehensively inhibit inflammatory factors, reduce inflammation and redness, soothe sensitive skin, resist streptococcal invasion, repair the barrier, and protect the balance of flora.

[0047] 2) This invention uses tea saponins to increase the number of beneficial bacteria (such as lactobacillus) and prebiotics (maltodextrin, inulin extract, α-glucan oligosaccharides), which can rapidly increase the number of beneficial bacteria, improve the skin microecology, restore skin health, and the soothing and repairing effects still exist after discontinuation of the medication.

[0048] 3) The novel sebum-like combination in this invention (ceramide NP, squalane, lecithin, phosphatidylcholine, and phytosterols) can mimic the components of human sebum, quickly repair the skin barrier, reduce skin moisture loss, and promote the repair of damaged skin; therefore, the skin has a good soothing and repairing effect after medication and still has a certain soothing and repairing effect after discontinuation of medication.

[0049] 4) By combining three transdermal penetration enhancers, this invention facilitates the complementary effects of different functions, enhances synergistic effects, further promotes the transdermal properties of functional molecules, thereby improving the efficacy of use and the effects after discontinuation of the drug, and enhances the skin feel.

[0050] 5) The composition with soothing and repairing effects prepared by the present invention can quickly rebuild the skin barrier, regulate the skin's immune function, improve the skin's microecology, synergistically enhance the effect, and quickly repair the skin. Detailed Implementation

[0051] Main source of materials:

[0052] Acrylic (ester) crosslinked polymer / C10-30 alkanol acrylate: Guangzhou Bailijia Technology Co., Ltd., viscosity: 40000 (S), model: U20.

[0053] Arginine / Lysine Peptide: Guangzhou Qianzi Biotechnology Co., Ltd., Product No.: WH-001879.

[0054] Lactobacillus plantarum: Shandong Junle Biotechnology Co., Ltd., Product No.: 027.

[0055] Macadamia ulmoides seed oil: Guangzhou Qianzi Biotechnology Co., Ltd., Product No.: WH-000243.

[0056] Ceramide NP: Guangzhou Baiyu Biotechnology Co., Ltd., Product No.: 2019.

[0057] α-Glucan oligosaccharide: pH value: 6.3~6.8, chitosan oligosaccharide content %: 15±2, monosaccharide content %: ≤0.5, ash content %: ≤0.3.

[0058] Polypropylene glycol diglycidyl ether: Jiangsu Maoyun Chemical New Materials Co., Ltd., Model: xy207.

[0059] Polycaprolactone: Wuhan Lanabai Pharmaceutical Chemical Co., Ltd., Product No.: EF234243.

[0060] Chrysanthemum indicum extract: Xi'an Jiahe Biotechnology Co., Ltd., Product No.: JH-183.

[0061] Hydrolyzed sodium hyaluronate: Shandong Baolijia Biotechnology Co., Ltd., Product No.: 20220819.

[0062] Matricaria extract: Shaanxi Sihai Biotechnology Co., Ltd., flavonoid content ≥3%, model: Matricaria extract.

[0063] Scutellaria baicalensis root extract: Xi'an Xinlu Biotechnology Co., Ltd., Model: XL.

[0064] Polygonum cuspidatum root extract: Xi'an Mixianer Biotechnology Co., Ltd., model: T583.

[0065] Example 1

[0066] A composition with soothing and repairing effects is prepared as follows:

[0067] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg *Chrysanthemum indicum* extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg *Macadamia ulmoides* seed oil, 0.05 kg magnolol, 0.02 kg *Chaenomeles speciosa* flower extract, 0.05 kg maltodextrin, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 0.02 kg *Ipomoea nil* root juice, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg *Scutellaria baicalensis* root extract, 0.06 kg *Polygonum cuspidatum* root extract, 0.05 kg fructose, 3 kg glycerin, 0.3 kg p-hydroxyacetophenone, and 5 kg 1... 3-Butanediol, 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.8 kg of α-glucan oligosaccharide, 0.3 kg of 1,2-hexanediol, and 74.69 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, 0.2 kg of Lactobacillus plantarum, and 1 kg of arginine / lysine peptide were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0068] Example 2

[0069] A composition with soothing and repairing effects is prepared as follows:

[0070] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg *Chrysanthemum indicum* extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg *Macadamia oleracea* seed oil, 0.05 kg magnolol, 0.02 kg *Chaenomeles speciosa* flower extract, 0.05 kg maltodextrin, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 0.02 kg *Ipomoea purpurea* root juice, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg *Scutellaria baicalensis* root extract, 0.06 kg *Polygonum cuspidatum* root extract, 0.05 kg fructose, 3 kg glycerin, and 0.3 kg p-hydroxyacetophenone. 5 kg of 1,3-butanediol, 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.8 kg of α-glucan oligosaccharide, 0.3 kg of 1,2-hexanediol, and 75.69 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, and 0.2 kg of Lactobacillus plantarum were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0071] Example 3

[0072] A composition with soothing and repairing effects is prepared as follows:

[0073] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg chamomile extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg macadamia seed oil, 0.05 kg magnolol, 0.02 kg matricaria flower extract, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg Scutellaria baicalensis root extract, 0.06 kg Polygonum cuspidatum root extract, 0.05 kg fructose, 3 kg glycerin, 0.3 kg p-hydroxyacetophenone, and 5 kg 1 3-Butanediol, 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.3 kg of 1,2-hexanediol, and 75.76 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, and 1 kg of arginine / lysine peptide were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0074] Example 4

[0075] A composition with soothing and repairing effects is prepared as follows:

[0076] The following ingredients were added: 0.5 kg of chamomile extract, 0.8 kg of hydrolyzed sodium hyaluronate, 0.8 kg of triethanolamine, 2 kg of macadamia seed oil, 0.05 kg of magnolia alcohol, 0.02 kg of matricaria flower extract, 0.05 kg of maltodextrin, 0.1 kg of ascorbyl palmitate, 0.02 kg of Ipomoea purpurea root juice, 4 kg of jojoba seed oil, 0.06 kg of Scutellaria baicalensis root extract, 0.06 kg of Polygonum cuspidatum root extract, 0.05 kg of fructose, 3 kg of glycerin, 0.3 kg of p-hydroxyacetophenone, 5 kg of 1,3-butanediol, and 0.5 kg of propylene. Acid (ester) compounds / C10-30 alkanol acrylate crosspolymer, 0.8 kg α-glucan oligosaccharide, 0.3 kg 1,2-hexanediol, and 80.19 kg water were added to a mixing tank, heated to 70°C, maintained for 30 min, and then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg tocopherol, 0.2 kg Lactobacillus plantarum, and 1 kg arginine / lysine peptide were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0077] Example 5

[0078] A composition with soothing and repairing effects is prepared as follows:

[0079] The following ingredients were added: 0.5 kg of chamomile extract, 0.8 kg of hydrolyzed sodium hyaluronate, 0.8 kg of triethanolamine, 2 kg of macadamia seed oil, 0.05 kg of magnolia alcohol, 0.02 kg of matricaria flower extract, 0.1 kg of ascorbyl palmitate, 4 kg of jojoba seed oil, 0.06 kg of scutellaria root extract, 0.06 kg of polygonum cuspidatum root extract, 0.05 kg of fructose, 3 kg of glycerin, 0.3 kg of p-hydroxyacetophenone, and 5 kg of 1,3-butanediol. 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.3 kg of 1,2-hexanediol, and 82.26 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at a stirring speed of 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol was added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0080] Example 6

[0081] A composition with soothing and repairing effects is prepared as follows:

[0082] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg *Chrysanthemum indicum* extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg *Macadamia ulmoides* seed oil, 0.05 kg magnolol, 0.02 kg *Chaenomeles speciosa* flower extract, 0.05 kg maltodextrin, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 0.02 kg *Ipomoea purpurea* root juice, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg *Scutellaria baicalensis* root extract, 0.06 kg *Polygonum cuspidatum* root extract, 0.05 kg fructose, 3 kg glycerin, 0.3 kg p-hydroxyacetophenone, and 5 kg 1,3-butanediol. 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.8 kg of α-glucan oligosaccharide, 0.3 kg of 1,2-hexanediol, and 71.69 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, 0.2 kg of Lactobacillus plantarum, 1 kg of arginine / lysine peptide, and 3 kg of a complex transdermal penetration enhancer were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0083] The preparation method of the composite transdermal penetration enhancer is as follows:

[0084] Mix 1 kg of transdermal permeation accelerator A, 20 kg of transdermal permeation accelerator B and 10 kg of transdermal permeation accelerator C and stir for 20 min at a stirring speed of 200 rpm. Then, evaporate and concentrate under reduced pressure to half the original volume to obtain a composite transdermal permeation accelerator.

[0085] The preparation method of the transdermal penetration enhancer A is as follows:

[0086] 0.02 kg of chitosan was added to 40 kg of 1 wt% acetic acid aqueous solution. The pH was adjusted to 4.5 with 0.1 mol / L NaOH aqueous solution. The mixture was stirred at 200 rpm for 20 min and filtered through a 400-mesh sieve to remove impurities, resulting in a chitosan mixture. 0.02 kg of sodium tripolyphosphate and 0.05 kg of farnesin were added to 50 kg of water and then added to the chitosan mixture while stirring at 200 rpm. The mixture was stirred for another 60 min and then transferred to a centrifuge tube. 50 kg of propylene carbonate was added, and the temperature was controlled at 20 °C. The mixture was centrifuged at 20,000 rpm for 25 min. The lower layer of particles was collected, rinsed with water, and dried at 20 °C for 12 h to obtain transdermal penetration promoter A.

[0087] The preparation method of the transdermal penetration enhancer B is as follows:

[0088] 0.3 kg of ceramide NP, 0.3 kg of polypropylene glycol diglycidyl ether, and 0.1 kg of lecithin were added to 10 kg of dipropylene glycol at 90 °C and stirred at 200 rpm for 1 h to obtain solution A. 0.5 kg of retinol was added to 5 kg of anhydrous ethanol to obtain solution B. Solution B was added to solution A, followed by the addition of 20 kg of water and 0.1 kg of sodium dodecyl sulfate, and stirred at 30 rpm for 5 min at room temperature to obtain transdermal penetration enhancer B.

[0089] The preparation method of the transdermal penetration enhancer C is as follows:

[0090] 0.33 kg of coconut oil, 0.038 kg of sorbitan monostearate, and 0.1 kg of polycaprolactone were added to a mixed solvent consisting of 24 kg of acetone and 3 kg of anhydrous ethanol. Then, 0.002 kg of phloretin was added to obtain an organic solution. The organic solution and 0.077 kg of polysorbate 80 were then added to 54 kg of water to obtain a suspension. The suspension was concentrated by evaporation under reduced pressure until the mass of the suspension was 10 kg, thus obtaining transdermal penetration enhancer C.

[0091] Example 7

[0092] The preparation method of the composition with soothing and repairing effects is basically the same as that of Example 6, the only difference being that the preparation method of the composition with soothing and repairing effects is different.

[0093] The composition with soothing and repairing effects is prepared as follows:

[0094] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg *Chrysanthemum indicum* extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg *Macadamia oleracea* seed oil, 0.05 kg magnolol, 0.02 kg *Chaenomeles speciosa* flower extract, 0.05 kg maltodextrin, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 0.02 kg *Ipomoea purpurea* root juice, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg *Scutellaria baicalensis* root extract, 0.06 kg *Polygonum cuspidatum* root extract, 0.05 kg fructose, 3 kg glycerin, 0.3 kg p-hydroxyacetophenone, and 5 kg 1,3-butanediol. 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.8 kg of α-glucan oligosaccharide, 0.3 kg of 1,2-hexanediol, and 71.69 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, 0.2 kg of Lactobacillus plantarum, 1 kg of arginine / lysine peptide, and 3 kg of transdermal penetration enhancer A were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0095] The preparation method of the transdermal penetration enhancer A is the same as that in Example 6.

[0096] Example 8

[0097] The preparation method of the composition with soothing and repairing effects is basically the same as that of Example 6, the only difference being that the preparation method of the composition with soothing and repairing effects is different.

[0098] The composition with soothing and repairing effects is prepared as follows:

[0099] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg *Chrysanthemum indicum* extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg *Macadamia oleracea* seed oil, 0.05 kg magnolol, 0.02 kg *Chaenomeles speciosa* flower extract, 0.05 kg maltodextrin, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 0.02 kg *Ipomoea purpurea* root juice, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg *Scutellaria baicalensis* root extract, 0.06 kg *Polygonum cuspidatum* root extract, 0.05 kg fructose, 3 kg glycerin, 0.3 kg p-hydroxyacetophenone, and 5 kg 1,3-butanediol. 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.8 kg of α-glucan oligosaccharide, 0.3 kg of 1,2-hexanediol, and 71.69 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, 0.2 kg of Lactobacillus plantarum, 1 kg of arginine / lysine peptide, and 3 kg of transdermal penetration enhancer B were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0100] The preparation method of the transdermal penetration enhancer B is the same as that in Example 6.

[0101] Example 9

[0102] The preparation method of the composition with soothing and repairing effects is basically the same as that of Example 6, the only difference being that the preparation method of the composition with soothing and repairing effects is different.

[0103] The composition with soothing and repairing effects is prepared as follows:

[0104] The following ingredients were added: 0.2 kg β-sitosterol, 0.5 kg *Chrysanthemum indicum* extract, 0.8 kg hydrolyzed sodium hyaluronate, 0.8 kg triethanolamine, 2 kg *Macadamia oleracea* seed oil, 0.05 kg magnolol, 0.02 kg *Chaenomeles speciosa* flower extract, 0.05 kg maltodextrin, 0.05 kg lecithin, 0.2 kg phosphatidylcholine, 0.1 kg ascorbyl palmitate, 0.02 kg *Ipomoea purpurea* root juice, 5 kg squalane, 4 kg jojoba seed oil, 0.06 kg *Scutellaria baicalensis* root extract, 0.06 kg *Polygonum cuspidatum* root extract, 0.05 kg fructose, 3 kg glycerin, 0.3 kg p-hydroxyacetophenone, and 5 kg 1,3-butanediol. 0.5 kg of acrylate / C10-30 alkanol acrylate crosspolymer, 0.8 kg of α-glucan oligosaccharide, 0.3 kg of 1,2-hexanediol, and 71.69 kg of water were added to a mixing tank. The mixture was heated to 70°C and maintained for 30 min, then stirred for 20 min at 200 rpm. The mixture was then cooled to 15°C, and 0.2 kg of tocopherol, 0.05 kg of ceramide NP, 0.2 kg of Lactobacillus plantarum, 1 kg of arginine / lysine peptide, and 3 kg of transdermal penetration enhancer C were added. The mixture was then stirred at 200 rpm for 20 min, allowed to stand for 24 h, filtered, and the filtrate was collected to obtain a composition with soothing and repairing effects.

[0105] The preparation method of the transdermal penetration enhancer C is the same as that in Example 6.

[0106] Test Example 1

[0107] Soothing and Repairing Effect Test

[0108] One hundred volunteers aged 20-40 years with acne inflammation were selected and randomly divided into 10 groups of 10 volunteers each. Each group corresponded to the compositions prepared in the test example and comparative example, respectively. Water was used as a blank control group. After washing their face morning and evening, volunteers applied the test sample at a dosage of 1±0.05g / time to their face for 7 consecutive days without using other skin care products or products with similar effects. After 7 days of continuous use, the efficacy of the product was evaluated using a scoring system. The efficacy was evaluated again using a scoring system 7 days after discontinuation of the product. The improvement of various symptoms (including stinging, burning, itching, and redness) was used as the basis for evaluation, with a maximum score of 10. The higher the score, the better the symptom relief and repair effect. The average score was calculated, and the average score of each symptom was then calculated to calculate the overall effect of the test sample. The test results are shown in Table 1.

[0109] Table 1: Results of the soothing and repairing effect test after 7 days of continuous use

[0110]

[0111]

[0112] Table 2: Results of the soothing and repair effects 7 days after discontinuation of medication

[0113] Test Plan stinging sensation burning sensation itching Redness and swelling Overall score Example 1 5.5 5.4 5.8 5.9 5.65 Example 2 4.6 4.4 4.7 4.4 4.525 Example 3 4.3 4.2 4.0 4.0 4.125 Example 4 4.1 4.2 4.1 4.0 4.1 Example 5 2.1 2.0 1.9 1.8 1.95 Example 6 7.8 7.4 7.7 7.9 7.7 Example 7 6.3 6.2 6.1 6.0 6.15 Example 8 6.0 6.1 6.1 6.0 6.05 Example 9 6.3 6.2 6.2 6.1 6.2 Blank control group 0.3 0.2 0.2 0.2 0.225

[0114] Test Example 2

[0115] Skin feel test

[0116] Test method: 100 volunteers aged 20-40 years were randomly selected and randomly divided into 10 groups of 10 people each. 1 mL of the sample from the example and comparative test was applied to the back of the left and right hands (blind test, the type of sample liquid was not disclosed). Water was used as a blank control group. The sample was applied evenly until absorbed. The skin feel effect was statistically analyzed by asking about indicators such as stickiness and absorption. The test results are shown in Table 3.

[0117] Table 3: Results of Skin Feel Test

[0118] Test Plan Skin feel effect Example 1 Sticky and slow to absorb Example 2 Sticky and slow to absorb Example 3 Sticky and slow to absorb Example 4 Sticky and slow to absorb Example 5 Sticky and slow to absorb Example 6 Non-sticky and absorbs quickly Example 7 Slightly sticky, absorbs quickly Example 8 Sticky, poorly absorbed Example 9 Slightly sticky, absorbs quickly Blank control group Non-sticky, absorbs slowly

[0119] The test results of Examples 1 and 2 show that Example 1 has the best efficacy both in use and after discontinuation among Examples 1-5. This may be because the present invention adds arginine / lysine peptides, which can directly protect and activate mitochondria, promote ATP production, enhance cell activity, eliminate ROS, strengthen tight junction proteins and the skin's mechanical barrier, tighten the skin, and comprehensively inhibit inflammatory factors, reducing inflammation and redness, soothing sensitive skin, resisting streptococcal invasion, repairing the barrier, and protecting the balance of the skin flora. Therefore, the efficacy of Example 1 in use and after discontinuation is better than that of Example 2. Furthermore, the imbalance of the skin's surface microecology is one of the important factors leading to skin damage. By increasing beneficial bacteria (such as lactobacillus) and prebiotics (maltodextrin, inulin extract, α-glucan oligosaccharides), the number of beneficial bacteria can be rapidly increased, improving the skin's microecology, restoring skin health, and the soothing and repairing effects remain even after discontinuation. The novel sebum-like combination (ceramide NP, squalane, lecithin, phosphatidylcholine, and phytosterols) can mimic the components of human sebum, quickly repair the skin barrier, reduce skin moisture loss, and promote the repair of damaged skin. Therefore, the skin has a good soothing and repairing effect after the medication is used, and it still has a certain soothing and repairing effect after the medication is stopped. Thus, Example 1 has better efficacy and discontinuation effect than Example 4.

[0120] Of Examples 1 and 6-9, Example 6 showed better results, possibly because the transdermal penetration enhancer A of this invention is prepared by modifying and grafting chitosan with sodium tripolyphosphate and farnesin to create positively charged spherical nanoparticles with a smooth surface. These nanoparticles have the ability to depolarize cell membranes, thus delivering functional ingredients to the skin, and are non-toxic to cells. By inducing the molecular binding of ceramide NP with polypropylene glycol diglycidyl ether and lecithin, the crystallization of ceramide NP was successfully prevented. A stable system with excellent high-temperature and high-salinity resistance was constructed. Modifying the lecithin layer through hydrophobic molecular binding between ceramide NP and lecithin enhances the transdermal performance of transdermal penetration enhancer B. Phloretin is safe for use in cosmetics and also possesses antitumor activity. Transdermal penetration enhancer C, prepared using phloretin, enhances the permeability of the stratum corneum and exhibits excellent permeability on the skin surface. Furthermore, the adhesion of transdermal penetration enhancer C to the skin is also enhanced, prolonging the contact time between functional substances and skin tissue. The three transdermal penetration enhancers were mixed, evaporated, and concentrated to obtain a composite transdermal penetration enhancer. The combination of the three enhances their respective functions, complementing each other and synergistically improving their effects, further promoting the transdermal properties of the functional molecules, thereby improving the efficacy during use and after discontinuation of the drug, and enhancing the skin feel. Therefore, Example 6 showed the best test results.

Claims

1. A soothing repair efficacy composition characterized in that, The composition comprises the following raw materials in percentage by weight: phytosterols 0.002-5%, feverfew extract 0.01-2%, hydrolyzed sodium hyaluronate 0.05-2%, tocopherol 0.003-3%, ceramide NP 0.005-5%, triethanolamine 0.1-2%, lactobacillus 0.005-5%, macadamia integrifolia seed oil 0.5-10%, magnolia alcohol 0.001-0.1%, mother chamomile flower extract 0.005-2%, malt dextrin 0.005-1%, lecithin 0.005-0.5%, phosphatidylcholine 0.001-0.5%, ascorbyl palmitate 0.005-0.5%, jatropha multifida root juice 0.001-5%, arginine / lysine polypeptide 0.0001-5%, squalane 0.5-20%, jojoba seed oil 1-15%, radix scrophulariae extract 0.04-0.08%, radix polygoni multiflori extract 0.04-0.08%, fructose 0.01-1%, glycerol 0.1-8%, p-hydroxyacetophenone 0.1-1%, butylene glycol 0.5-10%, acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer 0.1-2%, alpha-glucan oligosaccharide 0.05-5%, 1,2-hexanediol 0.1-1%, composite transdermal enhancer 1-5%, and water to make up the balance to 100%; The phytosterols are beta-sitosterol; The preparation method of the composite transdermal enhancer is as follows: 0.5-2 parts of transdermal enhancer A, 15-25 parts of transdermal enhancer B, and 5-15 parts of transdermal enhancer C are mixed and stirred for 10-30 min at a stirring speed of 100-300 rpm, and then concentrated under reduced pressure to a volume of 1 / 1.5-3 of the original volume to obtain the composite transdermal enhancer; The preparation method of the transdermal enhancer A is as follows: 0.01-0.03 parts of chitosan is added to 30-50 parts of 0.5-2 wt% acetic acid aqueous solution, 0.05-0.2 mol / L NaOH aqueous solution is used to adjust the pH to 4.0-5.0, and stirring is performed at 100-300 rpm for 10-30 min, and then impurities are removed by filtration through a 100-500 mesh screen to obtain a chitosan mixture; 0.01-0.03 parts of a cross-linking agent and 0.04-0.06 parts of farnesol are added to 40-60 parts of water, and the chitosan mixture is added under stirring at a speed of 100-300 rpm, and stirring is continued for 40-80 min, and then transferred to a centrifuge tube, 40-60 parts of propylene carbonate is added, the temperature is controlled at 10-30°C, and centrifugation is performed at 15000-25000 rpm for 10-30 min, and then the lower layer of particles is collected, washed with water, and dried at 10-25°C for 5-30 h to obtain the transdermal enhancer A; The cross-linking agent is sodium tripolyphosphate. The preparation method of the transdermal enhancer B is as follows: 0.2-0.4 parts of ceramide NP, 0.2-0.4 parts of polypropylene glycol diglycidyl ether and 0.05-0.2 parts of lecithin are added into 8-12 parts of dipropylene glycol at 70-95°C, and stirred at 100-300 rpm for 0.5-2 h to obtain solution A; 0.4-0.6 parts of retinol is added into 4-6 parts of anhydrous ethanol to obtain solution B; solution B is added into solution A, then 15-25 parts of water and 0.05-0.2 parts of sodium dodecyl sulfate are added, and stirred at room temperature at 30 rpm for 5 min to obtain the transdermal enhancer B; The preparation method of the transdermal enhancer C is as follows: 0.3-0.4 parts of coconut oil, 0.03-0.04 parts of sorbitan monostearate and 0.05-0.2 parts of polycaprolactone are added into a mixed solvent composed of 20-30 parts of acetone and 1-3 parts of anhydrous ethanol, and then 0.001-0.003 parts of phloretin is added to obtain an organic solution; then the organic solution and 0.07-0.08 parts of polysorbate 80 are added into 40-60 parts of water to obtain a suspension, and the suspension is concentrated by evaporation under reduced pressure until the suspension is 5-15 parts to obtain the transdermal enhancer C.

2. A method of making a soothingly repairing composition according to claim 1, characterized in that, The steps are as follows: the raw materials are weighed according to the percentage by weight, and then the plant sterols, feverfew extract, hydrolyzed sodium hyaluronate, triethanolamine, macadamia integrifolia seed oil, magnolia oil, mother chamomile flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, jatropha gossypiifolius root juice, squalane, jojoba seed oil, scutellaria baicalensis root extract, polygonum cuspidatum root extract, fructose, glycerol, p-hydroxyacetophenone, butanediol, acrylates / C10-30 alkyl acrylate crosspolymer, alpha-glucan oligosaccharide, 1,2-hexanediol and water are added into a stirring pot, heated to 60-80°C, kept for 10-40 min, then stirred for 10-40 min at a stirring speed of 100-300 rpm, cooled to 5-20°C, and then added with tocopherol, ceramide NP, lactobacillus, arginine / lysine polypeptide and the composite transdermal enhancer, stirred at 100-300 rpm for 10-40 min, left to stand for 20-40 h, filtered, and the filtrate is collected to obtain the composition having soothing and repairing effects.

3. Use of a soothing and repairing efficacy composition as claimed in claim 1, for the preparation of a cosmetic product, characterized in that, The dosage form of the cosmetic includes any one of water, emulsion, cream, mask and spray.

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