4 results about "TETRAHYDROPIPERINE" patented technology

The invention relates to an alkaloid liposome, a preparation process thereof and an application of the alkaloid liposome in an external preparation, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology which is higher in stability, safe and non-irritating. According to the scheme, the alkaloid liposome technology is characterized in that raw materials comprise alkaloid, hydrogenated lecithin, grease, polyhydric alcohols and water; the alkaloid is selected from at least three of piperine, tetrahydropiperine, tetrahydropalmatine, dihydrooat alkaloid D, caffeine and leonurine; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON80H or PhoslipTM HPC (Hydroxyethyl Propyl Phosphatidylcholine). The liposome is good in stability and low in irritation, and has the effects of promoting local tissue microcirculation, reducing choked flow rate, increasing local body temperature, enhancing tissue metabolism and improving local inflammation when being externally applied to skin.

The present disclosure relates to a dexmedetomidine microneedle patch, a method for preparing the same, and application thereof. The dexmedetomidine microneedle patch includes a substrate and a needle body disposed on a surface of the substrate, wherein the needle body includes dexmedetomidine hydrochloride, a matrix material, and a permeation enhancer. The permeation enhancer includes one or more of dodecyl-β-D-maltoside, ethylenediaminetetraacetic acid, and tetrahydropiperine.

The application discloses an alkaloid liposome and a preparation process and application thereof in external preparations, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology with higher stability and safety and no irritation. The scheme points are that raw materials include alkaloids, hydrogenated lecithin, oil, polyhydric alcohol and water; the alkaloids are selected from at least three kinds of piperine, tetrahydropiperine, fumarine, dihydroavenanthramide D, caffeine and leonuride; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON 80H or Phoslip HPC. The liposome has good stability and low irritation, and has the effects of promoting local tissue microcirculation, reducing resistance, improving local inflammation, improving local body temperature, enhancing tissue metabolism and the like when being used externally on the skin.

Methods for producing nanoparticles of hydrophobic compounds, such as EGCG-palmitate, Cannabidiol (CBD), Delta-9-tetrahydrocannabinol (THC-9), quercetin, ivermectin, retinoic acid, curcumin, resveratrol, lycopene, lutein, CoQ10, procyanidin B2, oxyresveratrol, tetrahydropiperine, rapamycin, forskolin, and tetrahydrocurcumin, are described. In some forms, one or more water soluble compounds are used with at least one hydrophobic compound to form the nanoparticles. Nanoparticles produced using the disclosed methods have tightly packed structures assembled by the hydrophobic compounds themselves, without the need for other components, such as surfactant, polymer, encapsulation, or metals. These nanoparticles can significantly increase the water solubility of hydrophobic compounds, allowing increased solubility and bioavailability in their own nanoparticle form.