21 results about "Oxyresveratrol" patented technology

The present application relates to a preparation method of high-efficiency stable mulberry root extract containing oxyresveratrol and its application in relieving skin itching, and belongs to the technical field of cosmetics. The preparation method of the mulberry root extract containing oxyresveratrol comprises the following steps: drying and crushing the root of a mulberry tree, adding the crushed root into an aqueous solution of a eutectic solvent to perform ultrasonic extraction, centrifuging the product to obtain the mulberry root extract containing oxyresveratrol. The present application is based on a green solvent system composed of betaine and 1,3-propanediol / ethyl lactate, and combines with mild ultrasonic conditions to realize the efficient extraction of oxyresveratrol from the mulberry root, so that the extraction rate is improved and the risk of high-temperature oxidation is avoided. Moreover, the obtained extract can not only long-acting inhibit the itch receptor MRGPX1, but also is suitable for sensitive skin due to the removal of irritating components, and has high efficiency and biocompatibility, thereby breaking through the environmental pollution and technical bottleneck of the traditional method and having a wide market application prospect.

The present invention provides the use of 4,3',5'-trihydroxy resveratrol compounds in the preparation of coronavirus 3CL protease inhibitors. The present invention discovers that 4,3',5'-trihydroxy resveratrol and its analogs have the activity of inhibiting coronavirus 3CL protease, and can play an anti-coronavirus role by inhibiting the activity of coronavirus 3CL protease. Among them, piceatannol, oxyresveratrol, physcion, 2,6,3',5'-tetrahydroxy stilbene, cis-tartriloside, 4-hydroxy resveratrol, and 4,3',5'-trihydroxy resveratrol have a half-maximal inhibitory concentration (IC50) against SARS-CoV and SARS-CoV-2 3CL proteases lower than 10 μM, showing good anti-coronavirus 3CL protease effect, effectively inhibiting the activity of coronaviruses, and can potentially be used for the prevention and / or treatment of coronavirus infections, and further for the preparation of drugs for the prevention and / or treatment of coronavirus infections.

The invention discloses a multi-dimensional firming and anti-wrinkle composition containing oxyresveratrol as well as a preparation method and application of the multi-dimensional firming and anti-wrinkle composition, and relates to the technical field of cosmetics. The invention provides a multi-dimensional firming and anti-wrinkle composition containing oxyresveratrol, which is characterized by comprising the following components in parts by weight: 0.1 to 5 parts of oxyresveratrol eutectic, 0.1 to 3 parts of albizia bark extract, 0.1 to 3 parts of nasturtium officinale extract and 0.01 to 1 part of eryngium maritimum extract. The invention provides a composition which comprises oxidized resveratrol eutecticum, albizia bark extract, watercress extract and eryngium maritimum L. The composition is prepared by reasonably compounding the oxidized resveratrol eutecticum with the albizia bark extract, the watercress extract and the eryngium maritimum L. extract. The skin aging problem caused by exogenous factors such as ultraviolet rays, life pressure and environmental pollution can be effectively relieved.

The invention relates to a soothing and repairing composition containing high-purity oxyresveratrol and application of the soothing and repairing composition. The composition is prepared from the following components: high-purity oxyresveratrol, a ganoderma lucidum extract, a hop extract, a cynara scolymus leaf extract and a vegetarian flower extract, the weight ratio of the high-purity oxidized resveratrol to the ganoderma lucidum extract to the humulus lupulus extract to the Huangfang flower extract is (0.05-0.5): (0.1-1): (0.1-0.8): (0.1-1). Through reasonable compounding of the four components of the high-purity oxidized resveratrol, the ganoderma lucidum extract, the humulus lupulus extract and the parsley flower extract, the soothing and repairing effects are achieved in the aspects of promoting collagen regeneration, promoting barrier protein, activating bitter receptors, inhibiting inflammatory factors and the like.

The invention relates to construction of a chinaroot greenbrier medicinal material fingerprint spectrum and application of the chinaroot greenbrier medicinal material fingerprint spectrum in medicinal material quality control. The HPLC fingerprint spectrum of the chinaroot greenbrier medicinal material has 23 characteristic fingerprint chromatographic peaks, the peak 6 is chlorogenic acid, the peak 7 is epicatechin, the peak 9 is 5-O-caffeoylshikimic acid, the peak 10 is polydatin, the peak 11 is oxyresveratrol, the peak 12 is neoastilbin, the peak 13 is astilbin, the peak 14 is neoiso-astilbin, the peak 15 is resveratrol, the peak 16 is engeletin, and the peak 17 is quercitrin. The peak 20 is kaempferol.

The invention relates to a tightening and relieving composition containing oxyresveratrol and application, and belongs to the technical field of cosmetics. The invention firstly provides a firming and relieving composition containing oxyresveratrol. The firming and relieving composition containing oxyresveratrol is prepared from oxyresveratrol particles, leontopodium alpinum extract, achillea millefolium extract and artemisia capillaris extract according to the mass ratio of (0.05-2): (1-5): (0.01-2): (0.01-2). Wherein the oxidized resveratrol particles are obtained by loading oxidized resveratrol with lignin as a carrier, and the light stability of oxidized resveratrol is greatly improved. In addition, through the synergistic effect of the four components, the composition can meet the firming and anti-aging effects in multiple aspects of promoting generation, inhibiting decomposition, accelerating cell renewal and the like of the collagen and the elastin.

The invention provides a skin whitening, maintaining and freckle removing essence formula based on plant extracts, and relates to the technical field of skin care, and the skin whitening, maintaining and freckle removing essence formula is characterized by comprising the following raw materials by weight: 3-8 parts of a peony root extract, 1.5-4 parts of oxyresveratrol, 0.5-2 parts of a coleus forskohlii root extract, and 1-3 parts of a Chinese wolfberry fruit extract. The composition is prepared from the following components in parts by weight: 2 to 5 parts of nicotinamide, 1 to 3 parts of acetylchitosamine, 2 to 6 parts of bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate, 4 to 8 parts of glycerol, 0.5 to 2 parts of panthenol, 0.1 to 0.3 part of sodium hyaluronate, 1.5 to 3 parts of polyglycerol-10 laurate, 0.1 to 0.3 part of xanthan gum, 0.8 to 1.5 parts of 1, 2-hexanediol, 0.3 to 0.7 part of caprylyl glycol and 0.1 to 0.5 part of citric acid. The whitening mask has the advantages that the whitening mask can fully act on generation and transfer of melanin, and the protection effect on the skin is improved while full whitening is achieved.

The invention discloses an application of an oxyresveratrol derivative in preparation of a whitening or freckle-removing product in the technical field of cosmetics, and particularly relates to any one of the following applications: (1) an application of the oxyresveratrol derivative as a tyrosinase inhibitor; (2) application of the oxidized resveratrol derivative as a PAR-2 inhibitor; and (3) application of the oxidized resveratrol derivative as an MNT-1 melanin synthesis inhibitor. The oxidized resveratrol derivative provided by the invention shows a core advantage far superior to that of a parent compound oxidized resveratrol in the field of whitening skin care products, efficient whitening regulation and control are realized from melanin synthesis and transport whole links, meanwhile, the problem of stability pain points of traditional whitening components is solved, and the oxidized resveratrol derivative is more prominent in effect, more excellent in stability and better in application prospect. The requirements of industrial production and marketization application of skin care products are better met.

The invention provides a mild resident whitening composition suitable for a wash-off product as well as a preparation method and application of the mild resident whitening composition, and the mild resident whitening composition is prepared from the following components in parts by weight: 0.01 to 1 part of oxyresveratrol, 1 to 8 parts of bentonite, 0.1 to 10 parts of polyquaternium-7, 0.1 to 10 parts of 1, 3-propylene glycol and 0.1 to 5 parts of tocopheryl acetate. Through bentonite interlayer confinement adsorption and a polyquaternium-7 hydrogen bond-cation synergistic anchoring mechanism and in combination with a 1, 3-propylene glycol-tocopheryl acetate double-effect stabilizing system, the whitening and brightening effects of efficient active matter residence are achieved, and the whitening and brightening composition is stable, non-degradable, mild and non-irritant in a weakly acidic environment and a surfactant system and has a good application prospect. The composition is suitable for people with sensitive skin.

The present application relates to a kind of oxyresveratrol-containing firming soothing composition and application, belong to the field of cosmetics.The present application first provides a kind of oxyresveratrol-containing firming soothing composition, including mass ratio (0.05-2) :(1-5) :(0.01-2) :(0.01-2) oxyresveratrol particle, high mountain fire-moss extract, yarrow extract, artemisia capillaris extract;Wherein oxyresveratrol particle is with lignin as carrier and is loaded oxyresveratrol, which greatly improves the light stability of oxyresveratrol.In addition, by the synergistic effect of the above four components, the composition can meet the firming anti-aging effect from the promotion of collagen and elastin, inhibition of decomposition, accelerate cell renewal and so on.

A method of reducing fat or treating obesity in a subject comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound of formula (A) :or a pharmaceutically acceptable complex thereof, and a pharmaceutically acceptable carrier; wherein formula (1), X1, X2, X3, X4, X5, L1, L2, L3, L4, L5, R1, R2, R3, R4, and R5 are each described herein.

The present application relates to a kind of multi-dimensional soothing care composition containing oxyresveratrol microcapsule and application, the composition includes the following components: oxyresveratrol microcapsule, kava leaf / root / stem extract, Tokyo sakura leaf extract and flaxseed extract;Oxyresveratrol microcapsule in the composition of the present application, using inulin as wall material, oxyresveratrol is wrapped, increase its solubility in water, and inulin can also improve the moisturizing effect of composition.The composition of the present application can achieve the effect of soothing and repairing from multiple aspects through the synergy of the four ingredients of oxyresveratrol microcapsule, kava leaf / root / stem extract, Tokyo sakura leaf extract and flaxseed extract.

The present disclosure relates to novel methods for producing resveratrol-type compounds (e.g., oxyresveratrol), salts thereof, hydrates thereof, and physical compositions thereof without the use of protecting group chemistry.

The invention relates to a moisturizing and anti-aging composition for improving skin barrier and a preparation method of the moisturizing and anti-aging composition, and particularly discloses a composition which is prepared by scientifically matching active ingredients such as oxyresveratrol and oat kernel protein and acceptable carriers in cosmetics, preferably further compounding phytosterol and nicotinamide, and through the synergistic effect of all the ingredients, the moisturizing and anti-aging effects of the composition are improved. The multiple effects of moisturizing, resisting aging, resisting oxidation and enhancing skin tolerance are achieved, and the technical problems that an existing skin care product is large in irritation, poor in moisturizing effect, weak in skin barrier repairing capacity and the like are solved.

Separator (12) for an electrochemical cell (10) that cycles lithium ions, wherein the separator (12) comprises: a microporous layer (28) with a first side (30) and an opposing second side (32), and one or more fire-retardant layers (34, 36) arranged on at least one of the first side (30) or the second side (32) of the microporous layer (28), wherein the one or more fire-retardant layers (34, 36) comprise cross-linked cyclopolyphosphazene particles, wherein the cross-linked cyclopolyphosphazene particles are formed by a nucleophilic polycondensation polymerization reaction between a cyclophosphazene and a comonomer, where cyclophosphazene is an organophosphorus compound with the following chemical formula: where X 1 , X 2 , X 3 , X 4 , X 5 , and X 6Each is a halid, and wherein the comonomer comprises 4,4'-(hexafluoroisopropylidene)diphenol, 4,4'-(9-fluorenylidene)diphenol, phenolphthalein, oxyresveratrol, resveratrol, dopamine, 4,4'-(hexafluoroisopropylidene)dianiline, 4,4'-sulfonyldianiline, 4,4'-(9-fluorenylidene)dianiline, anilinephthalein or a combination thereof.

A. A plant component complex extracted from young shoots and / or twigs of Morus alba L., containing 25. oxyresveratrol and 26. mulberoside A; B. A liquid extract in which the plant component complex A is dissolved, containing a solvent mixture containing i. 1,3-propanediol, ii. erythritol, and iii. water, wherein I) mixed solvent B) is an extraction solvent; II) the concentration of component a of plant component A is 0.01 to 0.1 wt %, preferably 0.02 to 0.05 wt %, based on the total weight of the liquid extract; and III) the concentration of component b of plant component A is 0.01 to 0.1 wt %, preferably 0.02 to 0.05 wt %, based on the total weight of the liquid extract. a liquid extract having a concentration of 0.007-0.07% by weight, preferably 0.01-0.04% by weight, relative to the total weight of the liquid extract, IV) the weight ratio (i.+ii.) / iii. in solvent mixture B is between 2.00 and 2.50, preferably 2.33, V) the weight ratio i. / ii. in solvent mixture B is between 7.75 and 16.50, preferably 10.66 to 13.00, and VI) the weighted sum of i.+ii.+iii.=100. This extract may be added directly to a composition for cosmetic use having a broad spectrum of anti-aging activity.

A liquid extract comprising: A. a plant complex extracted from branchlet and / or branchlet of white mulberry, the plant complex comprising 1. Oxyresveratrol, 2. Mulberroside AB, a solvent mixture in which the plant complex A is dissolved, the mixture comprising: i. 1, 3-propylene glycol, ii. Erythritol, iii. Water, where i. 1, 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, i. 3-propylene glycol, and i. 3-propylene glycol; i) mixed solvent B) for extraction solvent II) the concentration of a. Of the plant complex A is between 0.01 wt% and 0.1 wt%, preferably between 0.02 wt% and 0.05 wt%, based on the total weight of the liquid extract III) the concentration of b. Of the plant complex A is between 0.007 wt% and 0.07 wt%, based on the total weight of the liquid extract, preferably between 0.01 wt% and 0.05 wt%, based on the total weight of the liquid extract III) the concentration of b. Of the plant complex A is between 0.01 wt% and 0.1 wt%, preferably between 0.02 wt% and 0.05 wt%, based on the total weight of the liquid extract. The invention relates to an extract for cosmetic use, preferably between 0.01% by weight and 0.04% by weight, IV) the weight ratio of solvent mixture B (i. + i.) / i. Is comprised between 2.00 and 2.50, preferably 2.33, V) the weight ratio of solvent mixture B (i. / ii. Is comprised between 7.75 and 16.50, preferably it is comprised between 10.66 and 13.00, VI) the total weight of i. + i. + i. Is equal to 100, which can be added as such to a composition for cosmetic use with comprehensive anti-aging activity.

The invention relates to a preparation method of an efficient and stable mulberry root extract containing oxyresveratrol and application of the mulberry root extract in relieving skin itching, and belongs to the technical field of cosmetics. The preparation method of the mulberry root extract containing oxyresveratrol comprises the following steps: drying and crushing mulberry roots and stems, adding the crushed mulberry roots and stems into an aqueous solution of a deep-eutectic solvent, carrying out ultrasonic extraction, collecting a product, centrifuging, and taking supernate, so as to obtain the mulberry root extract containing oxyresveratrol. According to the method, on the basis of a green solvent system composed of betaine and 1, 3-propylene glycol / ethyl lactate and in combination with mild ultrasonic conditions, oxyresveratrol is efficiently extracted from mulberry roots, so that the extraction rate is increased, and the risk of high-temperature oxidation is avoided. And the obtained extract not only can inhibit the itch receptor MRGPX1 for a long time, but also is suitable for sensitive skin due to removal of irritant components, has high efficiency and biocompatibility, breaks through environmental pollution and technical bottlenecks of a traditional method, and has a wide market application prospect.

A method of reducing fat or treating obesity in a subject comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound of formula (A):or a pharmaceutically acceptable complex thereof, and a pharmaceutically acceptable carrier; wherein “”, X1, X2, X3, X4, X3, L1, L2, L3, L1, L5, R1, R2, R3, R4, and R5 are each described herein.

The present invention relates to a composition for alleviating, preventing, or treating Alzheimer's disease, the composition comprising apigenin and oxyresveratrol. A composition according to the present invention is highly effective in reducing Alzheimer's disease pathology caused by β-amyloid, which is increased by aging and oxidative stress, and improving β-amyloid-induced memory loss and cognitive function.

Methods for producing nanoparticles of hydrophobic compounds, such as EGCG-palmitate, Cannabidiol (CBD), Delta-9-tetrahydrocannabinol (THC-9), quercetin, ivermectin, retinoic acid, curcumin, resveratrol, lycopene, lutein, CoQ10, procyanidin B2, oxyresveratrol, tetrahydropiperine, rapamycin, forskolin, and tetrahydrocurcumin, are described. In some forms, one or more water soluble compounds are used with at least one hydrophobic compound to form the nanoparticles. Nanoparticles produced using the disclosed methods have tightly packed structures assembled by the hydrophobic compounds themselves, without the need for other components, such as surfactant, polymer, encapsulation, or metals. These nanoparticles can significantly increase the water solubility of hydrophobic compounds, allowing increased solubility and bioavailability in their own nanoparticle form.