35 results about "Oxyresveratrol" patented technology

Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.

The invention discloses a preparation method and an application of a mulberry twig effective part with a tyrosinase inhibiting effect and belongs to the technical field of medicine and food. The mulberry twig effective part with the tyrosinase inhibiting effect contains five polyphenol compounds which are extracted from mulberry twigs and have tyrosinase inhibiting activity, and the five polyphenol compounds include oxyresveratrol, Steppogenin, Moracin M, 2,4,2',4'-tetrahydroxychalcone and mole Morachalone A. The mulberry twig effective part with the tyrosinase inhibiting effect can be effectively applied to inhibition for enzymatic browning of fruits and vegetables and skin whitening of cosmetics, used for preventing and treating human pigmentation diseases and melanoma caused by excessive melanin, and applied to various preparations of drugs for treating diseases requiring inhibition of tyrosinase activity.

The invention discloses an oxyresveratrol microemulsion, and a preparation method and application thereof, belonging to the technical field of food, medicine and cosmetics. The microemulsion is composed of the following components in percentage by mass: 10-15% of surfactant, 5-10% of cosurfactant, 1-5% of oil phase, 70-80% of water phase and a right amount of oxyresveratrol. The microemulsion can be diluted into different concentrations according to actual demands. The target substance can not precipitate. The microemulsion can not stratify by centrifuging, is in the thermodynamically stable state, can be stored for a long time, does not have toxic or side effect on the human body, and can be used for fruit/vegetable enzymatic browning, preparation of whitening cosmetics and the like.

The invention discloses a whitening and freckle-fading composition and application thereof. The whitening and freckle-fading composition is prepared from the following raw materials: egg yolk oil andshea butter, pterostilbene and vitamin E, hydrolyzed ceramide III, an orange peel extract, a yeast extract, a thyme extract, a white willow bark extract, a verbascose flower extract, a sea lily nerveactivity whitening factor, a scutellaria baicalensis extract, oxyresveratrol, a lactobacillus fermentation lysate, tranexamic acid, VC ethyl ether, water-soluble fullerene, 4-butyl resorcinol and Ectoin; the invention also discloses application of the whitening and freckle-fading composition in cosmetics. The whitening and freckle-fading composition is good in safety and free of toxic and side effects, the whitening active ingredients are compounded, generation of melanin is inhibited from two ways of inhibiting saccharification and tyrosinase activity, and the whitening and freckle-fading effects are remarkable.

The invention relates to a whitening composition and a preparation method as well as application thereof. The whitening composition is prepared from the following components in percentage by mass: 0.01 to 10 percent of oxyresveratrol, 0.01 to 20 percent of radix scutellariae extract, 0.01 to 10 percent of herba thymi mongolici extract, 0.01 to 10 percent of fructus chebulae extract, 0.01 to 15 percent of hydrolyzed prunus domestica, 0.5 to 20 percent of nicotinamide and 0.01 to 10 percent of radix glycyrrhizae glabrae extract. According to the whitening composition disclosed by the invention,a balanced whitening effect can be achieved, i.e., all links of skin whitening can be comprehensively considered, and specifically, all links of melanogenesis incentives (inflammation), a melanogenesis process, a process of blocking transfer of melanin, a process of inhibiting phagocytosis of keratinocyte on the melanin, preventing the melanin from entering the stratum corneum, inhibiting color development and finally digesting and discharging the melanin and the like can be comprehensively considered.

The invention discloses a preparation method of oxyresveratrol microcapsules and products thereof. The method comprises the following steps: (1) selecting beta-cyclodextrin, chitosan, Arabic gum, and maltodextrin as split timbers, adding water for preparing a split timber aqueous solution, heating the split timber aqueous solution so as to completely dissolve the split timbers, and carrying out sterilization and homogenization on the obtained object so as to obtain an emulsion; (2) adding oxyresveratrol into a small amount of ethyl acetate and petroleum ether mixed solvent, heating for dissolving so as to obtain an oxyresveratrol solution; (3) cooling the emulsion obtained in the step (1) to 45-50 DEG C, stirring the emulsion to completely uniformly mix the emulsion, so that an emulsion with a solid content of 25-50% is obtained, and adding the oxyresveratrol solution to re-homogenize, so that an oxyresveratrol and split timber emulsion is obtained; and (4) carrying out spray drying on the oxyresveratrol and split timber emulsion obtained in the step (3), so that oxyresveratrol microcapsule powder is obtained. The method disclosed by the invention has the advantages of high embedding rate, high sample loading quantity, good water solubility, high stability and not easiness for discoloration, and the like.

The invention discloses application of stilbenoids in a quorum sensing system for inhibiting chromobacterium violaceum. The stilbenoids comprise three stilbenoids, namely, resveratrol, piceatannol and oxyresveratrol. In the chromobacterium violaceum, generation of purple pigment is controlled by quorum sensing. The three stilbenoids of resveratrol, piceatannol and oxyresveratrol can all significantly inhibit quorum sensing of the chromobacterium violaceum under the sublethal concentration condition, namely, the condition without influencing growth of the chromobacterium violaceum, wherein the activity of resveratrol is the highest. The three stilbenoids of resveratrol, piceatannol and oxyresveratrol can be prepared into a quorum sensing inhibitor to the chromobacterium violaceum, can effectively inhibit quorum sensing and prevent bacteria infection and has an important practical value in clinic bacteriostasis application.

The invention provides an oxyresveratrol synthesis method which comprises the following steps: firstly performing a reflux reaction between raw materials 3,5-dimethoxybenzyl alcohol and phosphorus oxychloride; after the reaction is complete, pressurizing and recycling the solvent; filtering, washing to neutrality and drying to obtain 3,5-dimethoxybenzyl chloride; performing a reflux reaction between the obtained 3,5-dimethoxybenzyl chloride and trimethyl phosphite in a solvent DMF (dimethyl formamide); after the reaction is complete, adding a catalyst sodium methylate solution, and adding a mixed solution of 2,4-dimethoxy benzaldehyde and DMF to obtain tetramethoxy diphenyl ethylene; and finally, performing a reflux reaction between the obtained tetramethoxy diphenyl ethylene and aluminum trichloride and xylene, wherein oxyresveratrol is obtained after the reaction is complete. According to the method provided by the invention, a Witting-Homer reaction is adopted, the raw materials are easily available, the yield is high, the cost is low, and the method is suitable for industrial production.

The invention relates to an oxyresveratrol synthesis method. The method concretely comprises the following steps: reacting 3,5-dimethoxybenzyl alcohol with an aqueous solution of hydrogen bromide to obtain 3,5-dimethoxybenzyl bromide, carrying out a reflux reaction of 3,5-dimethoxybenzyl bromide and triethyl phosphite in toluene, carrying out a Witting-Horner reaction of the obtained substance and 2,4-dimethoxybenzaldehyde under the action of an alkali to obtain 2,3',4,5'-tetramethoxystilbene, and demethylating 2,3',4,5'-tetramethoxystilbene by a Grignard reagent within a very short period of time to obtain oxyresveratrol. The oxyresveratrol synthesis method has the advantages of easily available raw materials, strong maneuverability of reaction conditions, and high yield.

The invention discloses an application of oxyresveratrol in preparing an ovary aging resistant medicine. The oxyresveratrol has significant treatment effects on various ovary aging diseases such as polycystic ovarian syndrome, dysfunctional uterine bleeding, premature ovarian failure and climacteric syndrome. The oxyresveratrol is prepared into the oral, transdermal or injection medicine for treating the ovary aging diseases.

The invention discloses an application of three stilbene compounds, namely resveratrol, piceatannol and oxyresveratrol, in inhibiting a pseudomonas aeruginosa quorum sensing system. Pseudomonas aeruginosa is one of the most common opportunistic pathogens which can cause serious acquired infection, and the quorum sensing system of the pseudomonas aeruginosa can regulate and control the generation of various virulence factors. In a sub-lethal concentration, the three stilbene compounds, namely the resveratrol, the piceatannol and the oxyresveratrol, can significantly inhibit the swarming of the pseudomonas aeruginosa and the generation of the virulence factor, namely pyocyanine, under the precondition of avoiding influence on the growth of the bacterium (the pseudomonas aeruginosa). The three stilbene compounds, namely the resveratrol, the piceatannol and the oxyresveratrol, can be prepared into pseudomonas aeruginosa quorum sensing inhibitors so as to effectively inhibit quorum sensing and prevent bacterium infection; and the inhibitors have an important practical value in clinical bacteriostatic application.

The invention relates to a whitening and freckle-removing composition, a whitening and freckle-removing soluble microneedle patch and a preparation method of the whitening and freckle-removing solublemicroneedle patch. The whitening and freckle-removing composition is prepared from oxyresveratrol, resveratrol and small molecular substances, wherein the micromolecular substance is prepared from the following components in parts by weight: 40 to 50 parts of alpha-arbutin, 40 to 50 parts of glutathione and 1 to 3 parts of soy isoflavone, and the ratio of the total mass of the oxyresveratrol andthe resveratrol to the mass of the micromolecular substance is 1 to (1 to 10). The whitening and freckle-removing soluble microneedle patch is prepared from viscous liquid composed of oxidized resveratrol and inclusion liquid of resveratrol, small molecular substances, a microneedle framework material and a first solvent, wherein the inclusion liquid of the oxidized resveratrol and the resveratrolis prepared from the oxidized resveratrol, the resveratrol, hydroxypropyl-beta cyclodextrin and a second solvent. The whitening and freckle-removing soluble microneedle patch has excellent mechanicalproperties and good whitening and freckle-removing effects.

The present invention pertains to methods (a) Inhibition of adenosine deaminase by resveratrol products including botanical extracts containing resveratrol and/or oxyresveratrol; (b) Biochemical Standardization of these products as Enzyme Inhibitory Units (EIU) per mg or gram; and (c) Their uses thereof.

The present invention relates to a process for separation of oxyresveratrol molecule from the extracted solution of Artocarpus lakoocha Roxb. through membrane application. The product can be obtained in excellent yield upto 81% in case of extraction using water as solvent and can be separated from the extracted mixture upto 98% using indigenously developed nanofiltration membrane. Only the desired Trans isomer is obtained and no cis isomerisation takes place during the extraction process.

The invention discloses mulberry bark powder, as well as a preparation method and application of the mulberry bark powder. The preparation method comprises the following steps: cleaning mulberry branches, and selecting the bast parts of the cleaned mulberry branches; drying the bast parts in the sun or in an oven, carrying out coarse grinding to obtain chippings, and then carrying out secondary grinding with a high-speed grinder; finally, carrying out ultrafine grinding with a high-speed grinder of which the sieve pore size is 100 meshes, thereby obtaining the mulberry bark powder of which the particle size is 100-150 micrometers. The mulberry bark powder contains 20-40% of a crude fiber, is rich in amino acids, phenolic acids, alkaloids, oxyresveratrol glucosides, flavonoid glycosides and other active substances, has a fine texture and a natural plant fragrance, can be utilized as an additive for preparation of flour food, tastes good and helps to promote gastrointestinal motility and change a diet structure, is low in fat and calorie, and has the functions of preventing diabetes and related complications, improving the self antioxidant capability, reducing the hyperglycemia risks caused by the circumstance that a diabetes patient eats too much high-sugar food like rice and bread, eliminating the sense of hunger, and effectively lowering blood sugar.

The invention relates to a process for extracting oxyresveratrol from mulberry twigs which serve as raw materials. The process comprises the steps of (1) extracting mulberry twigs by using an alcohol-water solution to obtain crude extracts; (2) conducting degreasing treatment on crude extracts to obtain semi-finished products; (3) dissolving semi-finished products with an alcohol-water solution to produce a loading solution with the turbidity lower than 0.5 degree, using a macroporous resin D101 separation column, conducting wet method loading, standing till resin reaches adsorption equilibrium, conducting gradient elution or isocratic sectional elution with the alcohol-water solution serving as an elution solution, collecting the elution solution with the oxyresveratrol mass fraction larger than 40%, combining, concentrating, and drying to obtain crude products; and (4) repeating purification in Step (3) for crude products, collecting the elution solution with the oxyresveratrol mass fraction larger than or equal to 96.97%, combining, concentrating, and drying to obtain the oxyresveratrol. By the aid of the process, the oxyresveratrol can be extracted from mulberry twigs efficiently, and the process is simple to operate, low in cost and applicable to large-scale production.

The invention relates to a synthetic method of oxyresveratrol. The synthetic method specifically comprises the following steps: carrying out Heck reaction on 4-idodine m-dihydroxybenzene and acrylic acid under the action of a palladium catalyst; then carrying out decarboxylation to generate an intermediate 2, 4-dyhydroxyl styrene without purification; enabling the unpurified 2, 4-dyhydroxyl styrene and 5-idodine m-dihydroxybenzene to directly react under the action of the palladium catalyst to obtain the oxyresveratrol. The synthetic method is simple in raw materials, high in the operability of the reaction condition, few in steps, short in reaction time and high in yield.

The invention discloses low-calorie fermented fruit and vegetable juice and a preparation method thereof. The juice consists of the following components in parts by weight: pullulan, stamen and pistilsugar, D-mannose, fructo-oligosaccharide, L-tagatose, L-fucose monosaccharide, beta-benzpyrole propanoic acid benzyl ester, 3-sieboldin, oxyresveratrol, beta-methyl escultin, dihydrocoriandrin, fruits and vegetables, aleppo avens, twig of winged euonymus, yerbadetajo herb, stabilizers, emulsifiers and antioxidants. The fruits and vegetables include passion fruits, avocado, naseberries, lychee, hawthorn fruits, spinach, celery, carrots, taro and lettuce. The fruits and vegetables are subjected to pulping, enzymolysis, enzyme inactivation and sterilization so as to obtain fruit and vegetable juice; then low-calorie sugar is added for fermentation treatment so as to obtain fermentation liquor; and then stirring, concentration and homogenization treatment are carried out to obtain the fermented fruit and vegetable juice with low calorie. The juice has good nutrients, a pure taste and strong stability, and can balance blood sugar.