461 results about "Tyrosinase" patented technology

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

The invention relates to the technical field of carbon black, in particular to a preparation process of high-adsorbability carbon black, which comprises the following steps: performing pore-forming treatment on carbon black to obtain a porous carbon black material, then treating the porous carbon black material with a first mixed amino acid solution to obtain a carbon black material loaded with a first mixed amino acid adsorption layer, and drying the carbon black material to obtain the high-adsorbability carbon black. And treating the carbon black material with a second mixed amino acid solution to obtain a carbon black material loaded with a second mixed amino acid adsorption layer, and treating the carbon black material loaded with mixed amino acids with laccase and tyrosinase. The carbon black product obtained by the preparation process has high adsorbability, and is used for treating metal ions in wastewater, so that the removal rate of the metal ions is greatly improved.

Provided are a whitening and freckle-removing composition, a gel, a preparation method therefor, and a use thereof, relating to the technical field of skin-care products. The whitening and freckle-removing composition comprises tranexamic acid, nicotinamide, 4-butylresorcinol, licorice extract, 3-o-ethyl ascorbic acid, and glutathione. For the whitening composition, by inhibiting the activity of tyrosinase, blocking the transfer of melanin from melanocytes to keratinocytes, and inhibiting the formation and accumulation of melanin by means of multiple mechanisms including oxidation resistance, and by means of the synergistic action of all components, cosmetic benefits of whitening and freckle-removing are achieved. The whitening and freckle-removing gel has a simple preparation method, has a mild and non-sensitizing formula, is safe and non-irritating, and is suitable for large-scale production and application.

The utility model provides a micro-fluidic chip and a micro-fluidic system, a micron-sized main channel is arranged in the micro-fluidic chip, and a sample to be detected is introduced into a generation area of the main channel to form a large number of micro-droplets. The micro-droplets serve as a reaction container to react with tyrosine and tyrosinase which are guided into the reaction area of the main channel, and finally absorbance testing can be conducted on the micro-droplets in the detection area of the main channel. The micro-droplets are small in volume, have high surface area to volume ratio, and can form a reaction container for efficient reaction. The microfluidic system can rapidly and accurately measure to-be-detected samples with different concentrations, and has the advantages of low reagent consumption, energy conservation, environmental protection, small required detection space, large-scale parallel operation and the like.

The invention relates to a multi-effect bionic liposome transdermal repair carrier and a preparation method and application thereof.The multi-effect bionic liposome transdermal repair carrier comprises active ingredients and a nano-carrier, and the active ingredients comprise sialic acid, saccharomycetes / rice fermentation product filtrate, arginine / lysine polypeptide and vitamin E in the mass ratio of (1-10): (2-8): (0.1-1): (0.5-4); the nano-carrier is prepared from the following raw materials: phospholipid, an emulsifier, polyhydric alcohol and water. Compared with the prior art, the anti-aging, whitening and moisturizing composition has the advantages of enhancing skin moisturizing and anti-oxidation effects, promoting collagen synthesis and inhibiting tyrosinase to achieve remarkable anti-aging, whitening and moisturizing effects and the like.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention belongs to the technical field of cosmetics, and discloses a whitening composition, application thereof and cosmetics. The whitening composition is prepared from the following active ingredients in parts by mass: 16 to 24 parts of coix seed fermentation liquor, 8 to 12 parts of Chinese herbaceous peony extract combined factors, 22 to 38 parts of 4-butylresorcinol solution and 2 to 8 parts of zinc gluconate, through the synergistic effect of the four components, the activity of tyrosinase can be effectively inhibited, synthesis of cell melanin can be effectively inhibited, and the whitening effect is good.

The invention provides a coordination nano assembly of chiral cyclopeptide and manganese ions as well as a preparation method and application of the coordination nano assembly. According to the method, a manganese superoxide dismutase protein structural domain and a unique tumor microenvironment of melanoma high tyrosinase are combined, and polypeptide sequences L-YD-hL-DD-h, L-YL-HL-DL-H and D-yD-hD-dD-h with different chirality are designed for the first time; the chirality of the polypeptide is regulated and controlled, the in-vivo circulation stability and the cell entry efficiency of the nano assembly are improved, the coordination self-assembly of manganese and different chiral cyclopeptides is realized, and the in-situ oxidation of an in-vivo tumor microenvironment is simulated for photo-thermal therapy and cell membrane coating. The method disclosed by the invention is simple, mild in experimental condition and easy to operate, the prepared cell membrane coated nano assembly not only has long circulation stability and high cell entry efficiency, but also can realize mild photo-thermal therapy through in-situ oxidation, releases manganese ions to activate a CGAS-STING pathway for immunotherapy of tumors, and has a wide application prospect. The potential application value is realized in the field of combined treatment of tumors.

The invention relates to a white tomato fermentation extract and a whitening tablet candy containing the white tomato fermentation extract. The white tomato fermentation extract is prepared by the following steps: mixing fresh white tomatoes with pleurotus citrinopileatus powder to prepare a fermentation raw material; inoculating saccharomycetes into the fermentation raw material to obtain a fermentation product; and drying the fermentation product to obtain the white tomato fermentation extract. The white tomato fermentation extract prepared by the preparation method disclosed by the invention has relatively good stability and is not easy to decompose in air and under strong light irradiation, so that the white tomato fermentation extract is relatively easy to store and transport, the antioxidant efficiency is not easy to reduce when the white tomato fermentation extract is used for preparing whitening products, and the prepared whitening tabletted candies containing the white tomatoes have relatively high antioxidant effects and can be used for preparing the whitening tabletted candies containing the white tomatoes. The whitening mask can be used for removing oxygen free radicals and inhibiting the formation of tyrosinase, and is an excellent whitening product.

The invention belongs to the technical field of cosmetics, and particularly relates to a skin-color-uniformizing whitening composition derived from plant extracts and application of the skin-color-uniformizing whitening composition. The whitening composition provided by the invention is prepared from the following components in parts by weight: 10 to 15 parts of saussurea involucrata extract, 1 to 8 parts of dendrobium officinale extract, 1 to 5 parts of wood apple extract and 0.5 to 5 parts of banana fruit extract. The four plant extracts are synergistically compounded, transdermal absorption of active ingredients can be promoted, the tyrosinase inhibition rate is effectively increased, and the skin glossiness and whiteness are improved, so that the effects of whitening, brightening and uniformizing the skin color are achieved, the whitening composition is mild and non-irritant, the preparation method is simple and convenient to operate, and the whitening composition has large-scale production capacity and industrial feasibility. When the whitening composition is applied to skin care products such as face cream, the whitening and brightening effects of the face cream can be effectively improved, and the whitening composition has wide market application value.

The invention belongs to the technical field of microorganisms, and discloses a Lactobacillus paracasei B20 for inhibiting melanin from a plateau area and application of the Lactobacillus paracasei B20, the Lactobacillus paracasei B20 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.32434, and the preservation date is October 31, 2024. Metabolite of the lactobacillus paracasei B20 comprises phenylalanine, p-hydroxycinnamic acid and the like, has strong tyrosinase inhibition effect and anti-ultraviolet ability, and can significantly reduce generation of melanin in skin. In addition, the lactobacillus paracasei B20 also has relatively strong oxidation resistance, has good tolerance in artificial gastric juice and artificial intestinal juice, and can smoothly reach the intestinal tract of a human body. In addition, the lactobacillus paracasei B20 has a relatively obvious growth inhibition effect on skin conditioned pathogens such as staphylococcus aureus and enterococcus faecalis.

The invention relates to the technical field of deep processing of paeonia ostii, in particular to paeonia ostii peptide capable of whitening, moisturizing, tightening and promoting collagen synthesis as well as a preparation method and application of the paeonia ostii peptide. The paeonia ostii flower peptide capable of whitening, moisturizing, tightening and promoting collagen synthesis is prepared through water bath, homogenization, alkali extraction and acid precipitation pretreatment, three times of enzymolysis through compound enzyme of acid protease, cellulase and pectinase and alkaline protease and solid-liquid separation, operation is easy, the requirement for equipment is low, and the paeonia ostii flower peptide is suitable for industrial large-scale production. The prepared paeonia ostii flower peptide has good inhibition capability on tyrosinase, hyaluronidase and elastinase, and also has excellent anti-saccharification and anti-inflammatory effects. Besides, five paeonia ostii active peptide fragments are screened out, are high in activity and non-toxic, can be combined with tyrosinase, hyaluronidase, MMP-1, MMP-3 and COX-2 receptor protein, and have the effects of whitening, moisturizing, tightening and promoting collagen synthesis.

The invention discloses a preparation method of high-purity recombinant mussel mucoprotein, and belongs to the technical field of recombinant protein preparation, the idea of improving target protein expression by adopting fusion protein is adopted, and fusion expression is performed on partial peptide fragments of an amino acid sequence of mytilus coruscus Mfp-3 and an amino acid sequence of common mussel preCol-D to obtain the high-purity recombinant mussel mucoprotein. The recombinant mussel mucin which is high in purity, low in endotoxin content and good in adhesion performance is obtained by combining improvement of induction, tyrosinase modification and separation and purification processes, a new thought is provided for industrial production of the recombinant mussel mucin through successful preparation of the recombinant mussel mucin, raw material support is provided for multi-field application of the recombinant mussel mucin, and the method is suitable for industrial production of the recombinant mussel mucin. The customized sequence recombinant mussel mucoprotein is prepared according to application requirements, and the application of the mussel mucoprotein in different fields is promoted.

The invention discloses an oligopeptide from undaria pinnatifida and application thereof. The amino acid sequence of the oligopeptide is YRKD, and the molecular weight is 580.63 g / mol. The polypeptide is identified from undaria pinnatifida through a high performance liquid chromatography technology for the first time, and an unreported oligopeptide capable of inhibiting tyrosinase and cooperating with vitamin C to synergistically inhibit tyrosinase is screened out. The oligopeptide derived from undaria pinnatifida is synthesized by a solid phase method, has the characteristics of safety, no toxicity, good water solubility and good stability, and is combined with vitamin C to generate a synergistic effect and synergistically increase the inhibition effect on tyrosinase, so that the oligopeptide can achieve a better tyrosinase inhibition effect at a lower and more stable concentration; the use concentration of the oligopeptide can be greatly reduced, the stability is enhanced, and the oligopeptide can be widely applied to preparation of cosmetics, medicines, health-care products or food additives, and has important economic value and social significance.

The invention discloses recombinant silk fibroin peptide as well as a preparation method and application thereof, and belongs to the technical field of cosmetic raw material development. The amino acid sequence of the recombinant silk fibroin peptide SFHR6 disclosed by the invention is as shown in SEQ ID NO. 1. Soluble expression of the recombinant silk fibroin peptide is achieved through prokaryotic expression and eukaryotic expression, the high-purity soluble recombinant silk fibroin peptide SFHR6 is obtained through nickel column affinity chromatography, hydrophobic chromatography, cation chromatography and anion chromatography technologies, and the recombinant silk fibroin peptide SFHR6 is high in purity, high in tyrosinase inhibition rate and strong in whitening effect. The purification process provided by the invention is simple and convenient, has good repeatability, effectively solves the quality control problem of naturally extracted protein products, has the advantages of high efficiency, high-purity heterologous expression and low large-scale production cost, and has relatively high industrial application potential.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus plantarum fermentation liquor and application thereof. The lactobacillus plantarum fermentation liquor provided by the invention is obtained by taking roses as a substrate and fermenting screened plant milk stalks under specific conditions. Experimental results show that the content of effective active ingredients such as total polyphenol, total polysaccharide and superoxide dismutase in rose fermentation liquor fermented by the lactobacillus plantarum is relatively high, and the fermentation effect of the rose fermentation liquor is far superior to that of commercially available common lactobacillus plantarum and other strains; besides, the rose fermentation liquor also shows obvious DPPH free radical and hydroxyl free radical scavenging ability, can effectively inhibit the activity of tyrosinase and improve the cell viability, has anti-aging and whitening effects, and can be widely applied to various foods and skin care products.

The invention belongs to the technical field of bioengineering, and particularly relates to an activity-improved tyrosinase mutant obtained by site-directed mutagenesis through an overlapping PCR technology, and preparation and application thereof. The tyrosinase mutant is obtained by mutation containing F337I / F352I on the basis of wild type tyrosinase as shown in SEQ ID NO.1, the enzyme activity of the tyrosinase mutant is obviously improved compared with that of the wild type tyrosinase, the F337I / F352I mutant gene is used for constructing a recombinant vector, and the recombinant vector is successfully expressed in bacillus subtilis WB600, bacillus amyloliquefaciens CGMCC No.11218 and bacillus licheniformis 2709, so that the tyrosinase mutant is obtained. The recombinant strain with improved enzyme production activity is further optimized through a fermentation process to obtain the novel tyrosinase.

The invention discloses a five-membered heterocyclic compound as well as a preparation method, an intermediate, a composition and application thereof. Specifically provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound provided by the invention has excellent biological activity; on one hand, free radicals can be removed, so that activation of tyrosinase is reduced; on the other hand, the activity of activated tyrosinase can be inhibited, and generation of melanin is reduced from multiple aspects; besides, the compound can reduce skin pigmentation induced by ultraviolet (UVB), has no obvious stimulation and inflammatory cell infiltration during administration, is safe and good in tolerance, has better solubility and preparation performance, is good in skin feeling, and is expected to be widely applied in the industries of medicine, cosmetics and beauty. # imgabs0 #

The application provides a tyrosinase-based transdermal delivery system for treating vitiligo, which is a core-shell structure, the core is tyrosinase, and the shell is a polymer shell layer. The application coats a polymer protective layer on the surface of the tyrosinase through in-situ polymerization reaction on the double bond of the tyrosinase, can effectively protect the activity of the tyrosinase and promote the transdermal delivery of the tyrosinase, and can control the targeted delivery of the tyrosinase nanogel to melanocytes in the deep part of the skin and hair follicle by adjusting the polymerization conditions of the polymer shell, so as to promote the in-situ synthesis of melanin. The transdermal delivery system of the application can also load active small molecules with anti-inflammatory function in the center of the tyrosinase, and the small molecules are released after being targeted and delivered to the inflammation area of vitiligo along with the tyrosinase nanogel, so as to relieve inflammation and protect melanocytes from damage.

The invention discloses glabridin liposome, a whitening product, a preparation method and application, and relates to the technical field of cosmetics. The glabridin liposome is prepared from the following components in percentage by mass: 0.5%-2.5% of glabridin, 1%-8% of phospholipid, 0%-1% of cholesterol, 10%-15% of liquid grease, 0.5%-1.5% of an emulsifier, 0.5%-1.5% of an antioxidant, 0.2%-1% of trehalose, 10%-30% of glycerol and the balance of water. Through innovation of the process and formula, the problems of instability of glabridin, non-uniformity of lipidosome and the like are solved, the encapsulation efficiency can be improved, the transdermal absorption capacity and stability can be improved, and the inhibitory activity on cell tyrosinase and melanin can be improved.

The invention discloses a chemical labeling system (HIM-IP) for detecting interaction between cells. According to the system, tyrosinase and phenol are respectively modified on the surfaces of two to-be-detected cells to construct capturing cells and prey cells, and then biotin or single-stranded DNA with nucleophilic groups is used as a molecular tag for labeling. The system not only can perform detection through traditional flow cytometry, but also can be compatible with a commercialized single cell transcriptome sequencing platform to realize association of intercellular interaction information and transcriptome information on a single cell level. The system does not need to carry out complex gene engineering modification on cells, the whole modification and marking process is simple, convenient and efficient, the detection sensitivity of intercellular interaction is high, and the biological mechanism of intercellular interaction regulation and control can be deeply excavated by integrating the single cell sequencing technology.

The invention relates to a mussel bionic adhesive material based on oligopeptide modified polyglutamic acid, and a preparation method and application thereof, and belongs to the field of bionic bio-based materials. The preparation method comprises the following steps: firstly, synthesizing tyrosine-containing oligopeptide through protease catalysis, and modifying the oligopeptide onto a polyglutamic acid skeleton to obtain a bionic polymer precursor; meanwhile, polyglutamic acid is modified by cysteine groups, so that a bionic high polymer material with reducibility is synthesized, and a required reducibility reaction environment is provided. The preparation method comprises the following steps: uniformly mixing the polyglutamic acid and the precursor, activating tyrosine in the precursor in a reducing environment by using tyrosinase, converting the tyrosine into dopa to finally obtain a bionic adhesive material solution, and adjusting the pH value of the solution to be close to an isoelectric point of the polyglutamic acid to realize self-assembly to form the adhesive. The adhesive prepared by the preparation method disclosed by the invention shows excellent adhesion performance and also shows good biocompatibility.

The invention relates to the field of cosmetics, in particular to application of tomato callus extract in preparation of anti-aging cosmetics and the cosmetics. According to the application of the tomato callus extract in preparation of the anti-aging cosmetics, the tomato callus extract is an aqueous extract of tomato calluses. The aqueous extract of the tomato callus can effectively reduce the concentration of inflammatory factors, can effectively promote healing of cell scratches, and can effectively improve the free radical scavenging rate of ABTS and DPPH (1, 1-diphenyl-2-picrylhydrazyl); the aqueous extract of the tomato calluses can effectively improve the tyrosinase inhibition effect, so that the aqueous extract of the tomato calluses can be applied to anti-aging cosmetics to achieve the anti-inflammatory, repairing, anti-oxidation and whitening effects, and the anti-aging effect can be achieved from the aspects of anti-inflammatory, repairing, anti-oxidation and whitening.

The invention provides a fish collagen peptide with a whitening effect and a preparation method thereof, and the method comprises the following steps: performing glycosylation modification treatment on fish collagen by using glucose, and then sequentially treating the fish collagen with gastric juice and intestinal juice to obtain the fish collagen peptide with a polypeptide sequence with glycosylation sites on a peptide chain. According to the invention, the fish collagen peptide with a remarkable inhibition effect on tyrosinase is obtained.

The invention discloses a strain of Blastococcus atamensis YC-1 and application of the strain of Blastococcus atamensis YC-1, and belongs to the field of microbial strains. The streptococcus sp. YC-1 provided by the invention has high antioxidant activity and also has the capability of producing DHHB (docosahexaenoic acid); meanwhile, the YC-1FLE is prepared by adopting absolute ethyl alcohol as a solvent, has no toxicity to HaCaT cells, is relatively high in reducing capacity, has a scavenging effect on DPPH free radicals, ABTS cation free radicals and hydroxyl free radicals, has a tyrosinase inhibition effect and shows good antioxidant and whitening effects; when the YC-1FLE is applied to the sunscreen lotion, the sunscreen coefficient of the sunscreen lotion containing the YC-1FLE is obviously higher than that of a blank control group, which shows that the YC-1FLE has better ultraviolet resistance. Therefore, the strain and the lysate extract of the fermentation product of the strain have huge application potential in the field of cosmetics.

The invention belongs to the technical field of functional food and health food, and particularly relates to a composition with skin whitening and brightening effects and a preparation method thereof. The composition comprises rice peptide, orange osmanthus pollen, white tomato powder, tremella polysaccharide, pomegranate concentrated powder and nicotinamide. Experimental results show that the composition reduces synthesis of melanin by inhibiting the activity of tyrosinase and achieves the effects of whitening and brightening the skin.

The invention provides a prinsepia utilis royle extract as well as a preparation method and application thereof, and the preparation method comprises the following steps: picking prinsepia utilis royle seeds, removing epicarp from the prinsepia utilis royle seeds, dehydrating to obtain dried kernels, preparing prinsepia utilis royle crude oil from the kernels by a subcritical extraction method, refining the crude oil by a deodorization vacuum process to obtain refined non-winterized prinsepia utilis royle oil, and drying the refined non-winterized prinsepia utilis royle oil to obtain the prinsepia utilis royle extract. And performing cold tank winterization treatment on the refined non-winterized prinsepia utilis royle oil to obtain the refined winterized prinsepia utilis royle oil. The prinsepia utilis royle extract obtained by the embodiment of the invention has good effects of resisting oxidation, inhibiting tyrosinase, inhibiting hyaluronidase, inhibiting elastinase, repairing zebra fish and the like.

The invention provides a preparation method of collagen yeast peptide, and belongs to the technical field of collagen biology. The preparation method comprises the following steps: adding collagen into water, uniformly stirring, then adding a nutrition enhancer accounting for 8-12wt% of the mixed system, and adjusting the pH value to 5.8-6.2 to obtain a fermentation substrate; and inoculating lactobacillus rhamnosus and lactobacillus plantarum into the fermentation substrate, controlling the dissolved oxygen to be 20-30% in the first 24 hours, reducing the dissolved oxygen to be 5-10% in the later 48 hours, and filtering and drying the fermented product to obtain the collagen fermented peptide. Through synergistic fermentation of composite strains, the product is rich in 300-1500Da bioactive peptide, Pro-Hyp-Gly and gamma-aminobutyric acid and has the functions of inhibiting tyrosinase, resisting oxidation, whitening and regulating intestinal flora, the melanin reduction rate reaches 22% in clinical 8 weeks, and the shelf life is prolonged to 18 months.

The invention relates to a modified superoxide dismutase pH response type nano-liposome and a synergistic anti-photoaging after-sun repair composition capable of achieving accurate targeting. The modified superoxide dismutase pH response type nano-liposome is obtained by modifying a superoxide dismutase nano-liposome with hyaluronic acid, and the modified superoxide dismutase pH response type nano-liposome has the advantages that the modified superoxide dismutase pH response type nano-liposome can be accurately targeted by the aid of the synergistic anti-photoaging after-sun repair composition; the superoxide dismutase nano-liposome is of a core-shell structure, a core layer is superoxide dismutase, a shell layer is a ternary composite liposome, and the ternary composite liposome is formed by compounding HSPC, DSPC and cholesterol. By constructing a pH response type nano delivery system, the pH drop characteristic of an ultraviolet damage area can be accurately recognized, controlled release of SOD at a target site is triggered, O2 <-> and H2O2 are synchronously removed, an oxidative stress chain reaction is blocked, and in cooperation with the inhibition of tetrahydrocurcumin on a tyrosinase signal channel and the anti-inflammatory repair effect of the aloe extract, the anti-inflammatory repair effect of the aloe extract on the tyrosinase signal channel is achieved. A three-dimensional action network of targeted removal-activity regeneration-barrier reconstruction is formed, and the photoaging prevention and treatment effect is improved.

The invention discloses preparation and application of a whitening and repairing composition containing temperature-sensitive oxidized resveratrol hydrogel, and relates to the technical field of cosmetics. The composition comprises the following components in parts by weight: 1-5 parts of temperature-sensitive oxidized resveratrol hydrogel, 4-6 parts of a peucedanum praeruptorum dunn extract, 1-3 parts of a willowleaf swallowwort rhizome extract and 0.1-0.5 part of a tephrosia rubescens seed extract. The combination of the peucedanum praeruptorum dunn extract, the cynanchum wilfordii extract, the tephros glauca seed extract and the oxyresveratrol finds that the composition has a synergistic interaction effect, and the composition formed by the components through specific compatibility has the effects of whitening, repairing and improving skin elasticity. The oxidized resveratrol is wrapped by the temperature-sensitive hydrogel, so that the oxidized resveratrol is kept in a gel state at an epidermal cuticle layer, and after the oxidized resveratrol permeates into a skin basal layer, the oxidized resveratrol can be released at the skin basal layer, acts on melanocytes more effectively, inhibits tyrosinase and further affects generation of melanin.