205 results about "Oligopeptide" patented technology

The invention relates to the technical field of food, in particular to geobacillus stearothermophilus cKM-Geo, application of the geobacillus stearothermophilus cKM-Geo, a shrimp shell oligosaccharide peptide compound and a preparation method of the shrimp shell oligosaccharide peptide compound. The invention provides geobacillus stearothermophilus cKM-Geo, the strain can grow in an oxygen-free environment, ventilation is not needed in the process, and proteolytic enzyme, cellulase, lipase and chitin deacetylase can be highly secreted and expressed; the invention further provides a preparation method for preparing the shrimp shell oligosaccharide peptide by utilizing geobacillus stearothermophilus cKM-Geo fermentation coupling steam explosion treatment, chitin and protein in the shrimp shell are converted into water-soluble oligopeptide and oligosaccharides, the water-soluble oligopeptide and oligosaccharides are separated from calcium carbonate in the shrimp shell, acid and alkali do not need to be used, in the process, waste water is little, pollution is little, and the method is suitable for industrial production. The resource utilization rate is high.

The invention discloses a freeze-dried essence with a repairing effect and a preparation method, and belongs to the field of skin care products, and the freeze-dried essence is composed of freeze-dried powder and an independent solvent liquid. The freeze-dried powder contains 0.5-3 parts of palmitoyl oligopeptide, 3-8 parts of I-type collagen, 1-5 parts of III-type collagen, 0.1-1 part of chitosan, 1-3 parts of secondary variable-temperature fermentation liquor of betula platyphylla and 2-8 parts of a freeze-drying protective agent; the solvent liquid is prepared from 0.5 to 3 parts of hyaluronic acid and 0.05 to 0.5 part of sodium polyglutamate. The preparation method comprises the following steps: a, adding fermentation liquor after dissolving; b, adding nano liposome and a protective agent; c, quickly freezing to-55 + / -2 DEG C by liquid nitrogen, and preserving heat for 2.5-3.5 hours; d, drying for 9-11 hours under the vacuum of 15-25 Pa and at the temperature of-18 + / -2 DEG C; and e, the temperature is increased to 15 + / -2 DEG C in a stepped mode, vacuum is smaller than or equal to 20 Pa, and drying is conducted for 18- Through scientific formula design, multiple effects of efficient repairing, anti-aging and relieving are achieved.

The invention discloses a composite combined preparation for synergistically treating and conditioning diabetes, relates to the technical field of foods, health foods or dietary supplements for adjuvant therapy and health care of diabetes, and in particular relates to a composite combined preparation for synergistically treating and conditioning diabetes. The preparation comprises albumin peptide, saussurea involucrata culture, vitamin B1, vitamin B2, wheat oligopeptide, corn oligopeptide, collagen peptide, mulberry leaf extract, rhizoma polygonati extract, sea-buckthorn extract, isomaltitol, maltodextrin, ginseng extract and bitter gourd extract. Through the synergistic effect of all the components, comprehensive auxiliary conditioning on diabetes is realized from multiple targets of maintaining colloid osmotic pressure and nutrition, regulating glycolipid metabolism in multiple ways, protecting pancreatic beta cell functions, enhancing insulin sensitivity, preventing nerve and blood vessel complications, meeting special diet requirements and the like. The composition can be prepared into food, health-care food or dietary supplement and other dosage forms.

The invention relates to repairing essence and a preparation method thereof, and belongs to the technical field of cosmetics. The repairing essence disclosed by the invention contains a repairing composition, wherein the repairing composition is prepared from oligopeptide-215, Ectoine, a codium tomentosum extract, a liquorice root extract and a purple coneflower extract; the purple coneflower extract is prepared by taking purple coneflower as a raw material, performing mixed fermentation through bacillus amyloliquefaciens and lactobacillus plantarum and then performing ultrasonic extraction, and the obtained purple coneflower extract has an improved anti-inflammatory effect. The five components in the repair composition can synergistically promote expression of skin barrier repair related proteins, and the repair essence containing the repair composition can significantly improve the skin TEWL value and the skin moisture content of a subject and improve the redness condition, and has significant moisturizing, soothing and barrier repair capabilities.

This invention relates to the field of cosmetics, and more particularly to active oligopeptides and their application in the preparation of anti-aging products. This invention provides an active oligopeptide with anti-aging activity, the amino acid sequence of which is shown in SEQ ID NO:1 and / or SEQ ID NO:4. This invention also provides an active oligopeptide (β1 and β1c) designed based on computational structural biology, targeting the β-Klotho FGF19 / / FGF21 and receptor-binding arm (RBA) region, and optimized for physicochemical properties, for use in skin anti-aging.

The application discloses a kind of earthworm protein with twelve 3 peptides, which is prepared by degrading earthworm protein with catalytic amount of Pro-Ala-Lys. The application also discloses the preparation method of the earthworm protein with twelve 3 peptides and the application of the earthworm protein with twelve 3 peptides in removing ·OH free radicals and DPPH free radicals. Experimental results show that the earthworm protein with twelve 3 peptides has excellent effects in removing ·OH free radicals and DPPH free radicals. Therefore, the earthworm protein with twelve 3 peptides provides an effective technical means for preparing ·OH free radical scavenger and DPPH free radical scavenger.

The present invention relates to a cosmetic composition comprising galactomyces, having skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving properties, and more specifically, comprises a galatomyces fermentation filtrate, a rice lees distillate, sh-oligopeptide-1, a plant extract, a skin conditioning agent, a pH regulator, a surfactant, an emollient, a sequestering agent, a film-forming agent, and a thickener. The cosmetic composition comprising said ingredients is less likely to cause skin irritation by having a large amount of natural ingredients, is eco-friendly by upcycling rice lees, exhibits skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving effects by containing an abundant amount of galactomyces, vitamins, minerals, and organic acid ingredients, and improves skin health by preventing skin aging and skin damage and promoting skin cell regeneration.

This application discloses a seaweed oligopeptide fertilizer for promoting root growth and seedling development, and its production process, belonging to the field of fertilizer technology. The fertilizer, by weight, comprises: 2-10 parts seaweed oligopeptide complex, 1-8 parts seaweed extract, 10-30 parts compound amino acids, 1-10 parts blueberry pomace, 20-50 parts oxytetracycline waste decomposition products, and 30-60 parts recycled organic matter from kitchen waste. By combining seaweed oligopeptides with chitosan to form a complex, the stability of the active ingredients is improved; simultaneously, the synergistic utilization of oxytetracycline fermentation waste, kitchen waste, and blueberry pomace achieves resource utilization. Experiments show that this fertilizer significantly promotes crop root growth and seedling development.

The invention belongs to the technical field of protein peptide preparation, and particularly relates to wheat oligopeptide with an anti-fatigue effect and a preparation method of the wheat oligopeptide. According to the method, the raw materials are subjected to enzymolysis by using the first compound enzyme containing bacillus subtilis protease and bromelain and the second compound enzyme containing trypsin, flavourzyme and papain step by step, and treatment of centrifugation, ultrafiltration and the like is combined, so that the yield and the taste of the product are improved, and the proportion of small molecular weight peptide in the product is high. Therefore, the wheat oligopeptide prepared by the method is high in yield and good in taste, not only is beneficial to improving the endurance of the body and prolonging the exercise time, but also can improve the energy metabolism condition in the body, delay the accumulation of lactic acid, urea nitrogen and creatine kinase in the body after exercise and increase the glycogen storage amount, and macroscopically shows certain anti-fatigue ability. The technical scheme of the invention has strong practicability, is beneficial to industrial production, and can be applied to preparation of anti-fatigue functional food.

The present invention relates to peptide conjugates that comprise a plant-derived oligopeptide capable of crossing the blood-brain barrier (BBB) and a therapeutic or diagnostic agent. The BBB-penetrating oligopeptide is an oligopeptide according to Formula I, Asp–R2–Gly–Leu–R5–R6–R7–Leu–Gly–R10–R11–R12, wherein R2 represents Arg, Lys, Cyt, D-Arg or Orn; R5 represents Phe, Arg, Lys, His, Trp, Tyr, D-Tyr, D-Phe, Orn, 4-aminophenylalanine or 3-phenylpropionate; R6 represents Pro, Leu, Glu or Lys; R7 represents Phe or Trp; R10, R11 and R12 each independently represent Lys, Arg or Orn; or an oligopeptide according to Formula II, Glu–R2'–R3'–Gly–R5'–R6'–Glu–R8'–R9'–R10'–Glu–R12'–Leu–Pro–Gly, wherein R2', R3', R8', R10' and R12' each independently represent Lys, Arg or Orn; R5' represents Phe, Ile, Arg, Lys, His, Trp, Tyr, D-Tyr, D-Phe, 4-aminophenylalanine, or 3-phenylpropionate; R6' represents Met, Leu, Ile, Asn, norleucin, D-norleucin, seleno- methionine or D / L-2-hydroxy-(4-methylseleno)butanoic acid; and R9' represents Leu or Ile. The conjugates comprising a BBB-penetrating oligopeptide compound and a therapeutic agent can be used in treatments for diseases of the central nervous system (CNS). Furthermore, conjugates with a BBB-penetrating oligopeptide compound and a diagnostic agent can be used in both in vivo and in vitro diagnostic methods.

The invention discloses a sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition and a preparation method thereof, the sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition is of a core-shell double-phase structure, and the sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition comprises an aqueous phase core, an aqueous phase core and a composite material, the active ingredient of the aqueous phase core is a covalent bond of carboxymethylated recombinant human collagen III and eclipta oligopeptide; the oil-phase layer wraps the water-phase core and comprises a sebum-imitating three-phase film as well as an antioxidant active matter and a slow-release carrier which are dispersed in the sebum-imitating three-phase film; wherein the volume ratio of the water-phase core to the oil-phase layer is 1: 2-1: 4, a core-shell double-phase structure with the carboxymethylated recombinant collagen-eclipta oligopeptide covalent bond as the water-phase core and the sebum-imitating three-phase membrane functional carrier as the oil-phase layer is constructed, and the limitation that active ingredients in a traditional formula are simply mixed is broken through. According to the structure, the stability of the water phase core is ensured through a chemical covalent bond, and the percutaneous permeability and biocompatibility of the composition are remarkably improved by utilizing the high similarity of a sebum-imitating film and skin lipid.

The invention belongs to the crossing field of marine biotechnology and bioinformatics, and particularly relates to a method for high-throughput identification of natural functional oligopeptides. At present, bottlenecks still exist in development and application of various functional oligopeptides such as penetrating peptides and antibacterial peptides in non-model species, and the high adaptability of the existing functional oligopeptides in complex and diverse non-model organisms is limited mainly due to differences (amino acid preference and receptor specificity) among species. Therefore, the invention provides a method for high-throughput identification of functional oligopeptides from natural sequences of organisms by means of machine learning. According to the method, based on a biological natural protein sequence, an oligopeptide sequence set meeting a preset length condition is generated through a sliding window strategy system, a deep machine learning model is utilized to perform high-throughput functional prediction on the oligopeptide sequence, and on the basis of performing'interruption-prediction-re-comparison 'on existing functional oligopeptides, the functional oligopeptide sequence set meeting the preset length condition is obtained. The comparison threshold value for accurately identifying the functional oligopeptide can be determined, and the natural functional oligopeptide existing in the protein sequence can be effectively identified based on the threshold value. The functional oligopeptide obtained by the method has strict screening of physicochemical properties of a machine learning model and high-adaptability biological characteristics formed in species evolution. According to the method, the direct application capability of the functional oligopeptide in non-model species is remarkably improved, and an accurate and high-throughput technical means is provided for efficient development and application of the functional oligopeptide in non-model organisms.

The application discloses a SIRT protein promoter and application thereof, and belongs to the technical field of cosmetics, and particularly relates to a SIRT protein promoter; the active ingredient of the SIRT protein promoter is oligopeptide-6; the oligopeptide-6 can not only activate an AMPK signal path, up-regulate NAMPT gene expression, and improve intracellular NAD + level, thereby activating SIRT protein in dependence on NAD + ; and can effectively promote collagen production, and realize the effects of anti-wrinkle and skin tightening.

The invention discloses a protein nanoparticle-nanofiber composite material and a preparation method thereof, and belongs to the technical field of food processing and functional protein materials. The method comprises the following steps: (1) taking fresh egg white, diluting and stirring to obtain uniform egg white protein dispersion liquid; (2) performing acylation modification on the egg white protein dispersion liquid to increase surface negative charges and improve conformation flexibility; (3) performing controllable enzymolysis on the acylated egg white protein, so that part of peptide chains of the acylated egg white protein are broken and oligopeptide with self-assembly capability is formed; and (4) carrying out heat treatment on the enzymolysis product, inducing the peptide fragment to be self-assembled to form nano-particles while inactivating the protease through heat treatment, further forming a nano-fiber network dominated by a beta-folding structure, and finally obtaining the protein nano-particle-nano-fiber composite system. Through the synergistic effect of acylation, enzymolysis and heat treatment, accurate conversion of protein from a natural spherical conformation to a functional nanostructure is achieved, and the obtained composite material has the dispersion stability of particles and the network enhancement effect of fibers and has excellent foamability, emulsibility and gelling property.

The invention discloses an anti-cancer oligopeptide designed based on threonine and analogues thereof and application of the anti-cancer oligopeptide, the anti-cancer oligopeptide is obtained by taking KLLKKLLKKLLKKKLLKW as a structural basis, replacing amino acids at different sites with hydroxyl-containing threonine or analogues thereof, and then amidating a C terminal; the structural general formula of the compound is as follows: KXmLKKLLKKLLKW-NH2, wherein X = T, pT, F, Y or pY, and p represents phosphorylation; and m is 2, 3, 6, 7, 10, 11 or 13. The anti-cancer oligopeptide has the advantages of high efficiency, low toxicity, short sequence and the like. In-vitro anti-tumor activity and toxicity experiment results show that the compound has a relatively strong killing effect on various tumor cells, and is low in hemolytic toxicity and high in therapeutic index. Serum stability experiments further show that the protein has relatively high enzymolysis stability. A scanning electron microscope experiment shows that the anti-cancer oligopeptide can quickly kill tumor cells through an effective membrane rupture mechanism. Therefore, the compound has a good application prospect in the aspects of research on novel high-efficiency low-toxicity polypeptide anti-cancer drugs, resistance to multidrug resistance and preparation of anti-cancer drugs.

This invention provides an oligopeptide cyclic peptide and its applications. The cyclic peptide is obtained by truncating the linear Hst1 sequence to the shortest possible sequence that retains Hst1 activity. Then, a triazole ring-containing oligopeptide is prepared by a cycloaddition reaction under specific conditions targeting this shortest sequence. Its molecular weight is only 1 / 3 that of linear histamine, and its biological activity is 15 times that of linear histamine. To achieve the same activity, the cost of the oligopeptide cyclic peptide is only 1 / 100 that of linear histamine, and the yield is significantly higher than that of cyclic peptides directly cyclized with amide bonds. It also exhibits significantly improved stability and resistance to biodegradation. The entire cyclization process of this oligopeptide cyclic peptide is mild, simple, and efficient, and can produce high-purity oligopeptide cyclic peptides. It can be used to prepare anti-aging and repairing skincare products, health products, or pharmaceuticals, and has excellent prospects for large-scale industrialization.

The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).

The invention discloses a composition for removing acne marks and inhibiting acne scar formation as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides a composition for removing acne marks and inhibiting acne scar formation. The composition is prepared from the following components in parts by weight: 0.01 to 4 parts of white willow bark extract, 0.01 to 1 part of tephrosia chinensis seed extract and 0.01 to 3 parts of oligopeptide, the oligopeptides comprise an oligopeptide A and an oligopeptide B; the oligopeptide A is tripeptide-1 copper, and the oligopeptide B comprises at least one of palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, acetyl hexapeptide-8 and decapeptide-4. The composition prepared from the white willow bark extract, the tephrosia glauca seed extract and the oligopeptide synergistically plays a role in three stages of post-acne repair, and the prepared composition has the effects of removing acne marks and inhibiting acne scar formation.

The invention provides an oligopeptide, and a lentiviral expression vector and a recombinant cell for expressing the oligopeptide. The invention further provides application of the compound in tumor treatment. After the oligopeptide is delivered to HT1080 cells through a lentivirus system, the intracellular SLC7A11 protein level is reduced, the intracellular Fe < 2 + > and lipid peroxidation level is remarkably increased, and the oligopeptide has a remarkable inhibition effect on cell proliferation and has the tumor treatment potential.

The active oligopeptide TDGLTSLD and the astragalus polysaccharide which can improve the resistance or the immunity or the growth capacity of animals are separated from the astragalus seedlings serving as a natural source, the feed containing the oligopeptide and the polysaccharide can effectively improve the immunity of the animals, the growth capacity such as the feed conversion ratio of the animals can be improved, and the feed has a wide application prospect.

The application discloses an oligopeptide targeting VEGFR2 and application thereof, and belongs to the technical field of biological medicines. The oligopeptide targeting VEGFR2 is intercepted from ramucirumab, and the applicant finds that the intercepted oligopeptide is specifically targeted to VEGFR2, and a tracer prepared by using the oligopeptide has higher tumor uptake, has ideal distribution in the body, meets the imaging requirement of clinical nuclear medicine, and has the potential of diagnosing or treating diseases related to VEGFR2 expression.

The invention belongs to the technical field of biology, and discloses a process for improving the fermentation rate of glutamic acid, which comprises the following steps: a fermentation medium containing oligopeptide is used for fermentation, and the amino acid sequence of the oligopeptide contains PSGPR. By optimizing the components of the fermentation culture medium, the density and activity of the strain are improved, so that the glutamic acid fermentation efficiency is promoted to be improved.

The present disclosure relates to an oligopeptide. The oligopeptide comprises an amino acid sequence. The amino acid sequence comprises a binding motif, and the binding motif has a specific amino acid sequence. The present disclosure also relates to a test kit comprising an oligopeptide and a pharmaceutical composition comprising an oligopeptide.

The application discloses a biological additive for promoting poultry feather development and application thereof, and belongs to the technical field of animal breeding. The biological additive is prepared from scallop skirt oligopeptide and cantharides polypeptide at a mass ratio of 1:1. Animal experiments show that, when meat chickens are fed with 60 mg of the biological additive per 1 kg of basic feed, the growth of the meat chickens can be promoted, and more importantly, the feather development of the meat chickens can be significantly and synergistically promoted, and the length of the main wing feathers is obviously increased. Cytological studies further prove that the biological additive can synergistically promote the proliferation of poultry hair follicle epidermal stem cells, and the effect is better than that of an EGF positive control. Therefore, the biological additive developed by the application is safe, efficient and green, effectively solves the problems of drug residues and drug resistance possibly caused by traditional chemical additives, provides a sustainable solution for poultry breeding, and has important economic and application values.

This invention relates to the field of biomaterial synthesis technology, specifically disclosing a method for preparing a class of catechol derivatives and their applications, administration, and preparation apparatus. The methods include: preparing dopa or carbidopa derivatives using a sodium sulfite-boric acid-argon protective system in an organic-aqueous mixture; or using dopa as a raw material, performing a methyl esterification reaction with SOCl2 and anhydrous methanol, followed by an exchange reaction with methyl trifluoroacetate to achieve a one-pot synthesis of Tfa-DOPA-OMe; or preparing acetal-protected tanshinone derivatives based on dopa derivatives or tanshinone and its derivatives; or using acetal-protected tanshinone and its esters to prepare natural catechol compounds such as Shimobashiric acid C, and preparing non-natural catechol compounds through coupling reactions with organic acids, amino acids and their derivatives, oligopeptides and polypeptides, alcohols, or sugars. Highly selective deprotection conditions achieve the goal of completely and thoroughly removing the acetal protection of catechols without destroying the ester bonds within the molecular structure.

The invention discloses a composite multi-oligopeptide composition for skin repair and an application of the composite multi-oligopeptide composition. The multi-oligopeptide composition comprises the following components in parts by weight: 1 to 5 parts of acetyl hexapeptide-8, 0.1 to 1.5 parts of acetyl tetrapeptide-3, 1 to 20 parts of acetyl tetrapeptide-9, 0.1 to 1.5 parts of acetyl tetrapeptide-11, 10 to 190 parts of carnosine, 10 to 100 parts of decarboxylated carnosine hydrochloride, 10 to 120 parts of tripeptide-1, 1 to 50 parts of tetrapeptide-4, 1 to 20 parts of hexapeptide-9, 1 to 10 parts of palmitoyl pentapeptide-4, 1 to 5 parts of palmitoyl tetrapeptide-7, 1 to 10 parts of palmitoyl tripeptide-1, 1 to 35 parts of palmitoyl tripeptide-8, 0.1 to 2.5 parts of oligopeptide-1, 0.1 to 0.5 part of oligopeptide-2 and 0.1 part of carnosine. And 1 part of oligopeptide-5. The multi-oligopeptide composition has excellent anti-wrinkle and anti-aging effects, has the effects of promoting tissue repair and wound healing, strengthening skin barrier and resisting inflammation and relieving, is applied to skin medicine and skin beauty, and has the effects of promoting regeneration and remodeling of an extracellular matrix (ECM), regulating inflammation, blocking inflammatory aging and strengthening a dermis-epidermis joint (DEJ).

This application relates to the field of health product technology, specifically disclosing a facial mask with whitening, moisturizing, and freckle-removing functions and its preparation method. This facial mask with whitening, moisturizing, and freckle-removing functions comprises the following components in parts by weight: 15-25 parts of peach blossom Bletilla striata polysaccharide complex, 5-12 parts of silkworm pupae enzymatically hydrolyzed oligopeptides, 10-20 parts of biomimetic membrane-modified starch microspheres, 35-50 parts of winter melon juice lactic acid bacteria fermentation supernatant, and 1-3 parts of antioxidant complex. This application uses peach blossom Bletilla striata polysaccharide complex, silkworm pupae enzymatically hydrolyzed oligopeptides, biomimetic membrane-modified starch microspheres, winter melon juice lactic acid bacteria fermentation supernatant, and antioxidant complex in a compounded manner according to their weight proportions. The complex and oligopeptides exist in a molecular-level dispersion state, the microspheres act as carriers to uniformly carry the active components, and the antioxidant complex maintains the stability of the system. Therefore, it achieves the effects of highly dispersed active ingredients, sufficient contact with the skin during application, and improved retention rate of active substances after washing.

The invention discloses flaxseed and wheat oligopeptide mixed powder with an effect of improving sarcopenia, and belongs to the field of biological medicines. The invention relates to a composition with an effect of improving sarcopenia. The composition comprises active ingredients including wheat oligopeptide and flaxseed meal, wherein the flaxseed powder contains secoisolariciresinol diglucoside, and a mixture of small molecules with the molecular weight smaller than 1000 Da in the wheat oligopeptide accounts for 90% or above. The invention discloses a differentiated molecular path on which the two components play roles, the wheat oligopeptide has outstanding effects in the aspects of remarkably activating a PI3K / Akt pathway and promoting FOXO3a phosphorylation inactivation, the mechanism complementarity of'upstream regulation 'and'downstream blocking' lays a solid theoretical foundation for realizing a more comprehensive anti-atrophy effect through combined use, and the wheat oligopeptide has a good application prospect. And a composite scheme with a fuzzy mechanism in the prior art is exceeded. In addition, the formula disclosed by the invention can also improve the in-vivo environment which is not beneficial to muscle maintenance from the source by relieving chronic inflammation and oxidative stress.

The application discloses a dry-cured ham source oligopeptide and application thereof. The dry-cured ham source oligopeptide comprises at least one of the following amino acid sequences: ELIDQDARDLY, YHEHRSDLN, YKATEPVIAF, INKVEELKKKY and GEKLKRQKY. The dry-cured ham source oligopeptide is applied to preparation of a drug for treating a glycolipid metabolism disorder disease. The extracted and verified oligopeptide can be specifically combined with an AdipoR2 receptor, has stronger glycolipid metabolism regulation activity than a KRQKYD polypeptide, can significantly improve various glycolipid metabolism disorder diseases, and has a good application prospect.