4 results about "ASIATIC ACID" patented technology

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method.The asiatic acid derivative provided by the present application has R which is a straight chain or a branched chain with 1-24 carbon atoms, or a saturated or unsaturated monohydric alcohol alkyl formed by removing a hydroxyl group.The R group of the asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility compared with asiatic acid, is easily dissolved in natural oil, alkane and other ester solvents, and has obviously enhanced biological activity, so that the asiatic acid derivative of the present application has high availability, improves the inhibition effect of the asiatic acid derivative on EDNRA and TRPV1, and further improves the anti-tumor effect, and the asiatic acid derivative has no safety risk.

The application provides a skin bacteriostatic repair emulsion and a preparation method thereof, and relates to the field of cosmetics. The skin bacteriostatic repair emulsion comprises an oil phase, an aqueous phase and an emulsifier, the components of the oil phase are dispersed in the aqueous phase in the form of droplets under the action of the emulsifier, and the particle size of the droplets is not more than 200 nm; the components of the oil phase comprise at least one of cinnamaldehyde octadecylamine complex, paeonol octadecylamine covalent coupling compound and asiatic acid. The embodiment of the application can well improve the physicochemical properties of cinnamaldehyde, paeonol and asiatic acid, so that the cinnamaldehyde, the paeonol and the asiatic acid can exist stably and in a large amount in actual use, and have a good treatment effect on acne.

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method. The asiatic acid derivative provided by the present application has R which is an alkyl group formed by removing a hydroxyl group from a saturated or unsaturated monohydric alcohol, and the saturated or unsaturated monohydric alcohol includes one of ethanol, octanol, hexadecanol, stearyl alcohol, 2-hexyl-1-decanol, decyltetradecin, oleyl alcohol, cis,cis-9,12-octadecadienol and bisabolol. The asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility, is easily soluble in natural oil, alkane and other ester solvents, and has a significant inhibitory effect on EDNRA and TRPV1 and obviously enhanced bioactivity. The asiatic acid derivative of the present application has high availability, and the asiatic acid derivative has no safety risk.

This invention discloses a microcapsule with time-released baicalein and asiatic acid nanoparticles, its preparation method, and its application. The preparation method of the microcapsule includes: firstly, synthesizing baicalein nanoparticles and asiatic acid liposomes separately; then, using microfluidic electrospray technology, preparing core-shell structured microdroplets with a sodium alginate solution loaded with baicalein nanoparticles as the outer phase and a sodium alginate solution loaded with asiatic acid liposomes as the inner phase; finally, solidifying with calcium chloride solution to obtain core-shell microcapsules. The microcapsule of this invention utilizes its unique core-shell structure to preferentially release baicalein nanoparticles in the shell layer in a physiological environment to achieve early antibacterial effects, followed by the release of asiatic acid liposomes in the core layer to promote later cell migration and tissue repair, achieving time-sequential drug release that matches the wound healing process. This microcapsule significantly improves the bioavailability and delivery controllability of poorly soluble traditional Chinese medicine active ingredients, and has broad application prospects in the field of wound repair.