9 results about "ASIATIC ACID" patented technology

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method.The asiatic acid derivative provided by the present application has R which is a straight chain or a branched chain with 1-24 carbon atoms, or a saturated or unsaturated monohydric alcohol alkyl formed by removing a hydroxyl group.The R group of the asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility compared with asiatic acid, is easily dissolved in natural oil, alkane and other ester solvents, and has obviously enhanced biological activity, so that the asiatic acid derivative of the present application has high availability, improves the inhibition effect of the asiatic acid derivative on EDNRA and TRPV1, and further improves the anti-tumor effect, and the asiatic acid derivative has no safety risk.

The present application provides a kind of epidermis repair gel dressings and its preparation method, it is related to dressing field.The epidermis repair gel dressings includes repair liquid, 100 parts of the repair liquid includes composite sodium hyaluronate 0.1-0.3 parts, carbomer 0.02-0.06 parts, glycerol 1-4 parts, pentanediol 1-3 parts, composite acid 0.05-0.1 parts, composite peptide 0.01-0.03 parts and the balance purified water by weight parts;The composite sodium hyaluronate is composed of sodium hyaluronate, hydrolyzed sodium hyaluronate and sodium hyaluronate crosslinked polymer;The composite acid is prepared from ursolic acid, hydroxyl asiatic acid, lipoic acid;The composite peptide is prepared from thirteen peptides and palmitoyl pentapeptide-3.The epidermis repair gel dressing of the present application has better repair effect on acne lesions, not only inhibits active propionibacterium acnes, but also can reduce the expression of inflammatory factors, can deeply repair damaged basal structure, maximumly reduce the degree of acne lesions, and restore to close normal skin.

The invention discloses an asiatic acid saponin compound and medical application thereof. The asiatic acid saponin compound comprises a compound with a structural formula as shown in a formula (I), and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula (I) has anti-inflammatory and anti-ulcer activity, so that the compound can be used for preparing medicines for preventing or treating inflammatory diseases or ulcerative diseases.

The application provides a skin bacteriostatic repair emulsion and a preparation method thereof, and relates to the field of cosmetics. The skin bacteriostatic repair emulsion comprises an oil phase, an aqueous phase and an emulsifier, the components of the oil phase are dispersed in the aqueous phase in the form of droplets under the action of the emulsifier, and the particle size of the droplets is not more than 200 nm; the components of the oil phase comprise at least one of cinnamaldehyde octadecylamine complex, paeonol octadecylamine covalent coupling compound and asiatic acid. The embodiment of the application can well improve the physicochemical properties of cinnamaldehyde, paeonol and asiatic acid, so that the cinnamaldehyde, the paeonol and the asiatic acid can exist stably and in a large amount in actual use, and have a good treatment effect on acne.

The invention discloses an asiatic acid saponin compound and medical application thereof. The asiatic acid saponin compound comprises a compound with a structural formula as shown in a formula (I), and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula (I) has anti-inflammatory and anti-ulcer activity, so that the compound can be used for preparing medicines for preventing or treating inflammatory diseases or ulcerative diseases.

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method. The asiatic acid derivative provided by the present application has R which is an alkyl group formed by removing a hydroxyl group from a saturated or unsaturated monohydric alcohol, and the saturated or unsaturated monohydric alcohol includes one of ethanol, octanol, hexadecanol, stearyl alcohol, 2-hexyl-1-decanol, decyltetradecin, oleyl alcohol, cis,cis-9,12-octadecadienol and bisabolol. The asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility, is easily soluble in natural oil, alkane and other ester solvents, and has a significant inhibitory effect on EDNRA and TRPV1 and obviously enhanced bioactivity. The asiatic acid derivative of the present application has high availability, and the asiatic acid derivative has no safety risk.

The invention discloses a composition containing ganoderma sinensis fermented filtrate and application of the composition in skin repairing and whitening. The invention belongs to the technical field of cosmetics, and provides a composition which comprises ganoderma sinensis fermentation filtrate, tocopheryl acetate, ascorbyl glucoside, bisabolol, madecassic acid and ferulic acid. The natural multi-effect Ganoderma sinensis fermentation filtrate is taken as a core basis, two core pain points of skin barrier damage and melanin deposition are solved in a targeted manner, specific components are compounded, and multi-dimensional synergistic interaction of skin repair'anti-inflammation-infiltration promotion-active reconstruction 'and whitening'enzyme inhibition-reduction-stabilization-antioxidation' is realized, so that the skin care effect is improved, and the skin care effect is achieved. Meanwhile, the skin microenvironment and the stability of active ingredients are optimized, a synergistic effect is achieved through multiple channels, multi-directional repairing is achieved, the obvious effects of promoting skin barrier repairing, reducing inflammatory hyperpigmentation and inhibiting melanogenesis are achieved, and the composition can be used for preparing more cosmetics for repairing skin and whitening and brightening the skin.

This invention discloses a microcapsule with time-released baicalein and asiatic acid nanoparticles, its preparation method, and its application. The preparation method of the microcapsule includes: firstly, synthesizing baicalein nanoparticles and asiatic acid liposomes separately; then, using microfluidic electrospray technology, preparing core-shell structured microdroplets with a sodium alginate solution loaded with baicalein nanoparticles as the outer phase and a sodium alginate solution loaded with asiatic acid liposomes as the inner phase; finally, solidifying with calcium chloride solution to obtain core-shell microcapsules. The microcapsule of this invention utilizes its unique core-shell structure to preferentially release baicalein nanoparticles in the shell layer in a physiological environment to achieve early antibacterial effects, followed by the release of asiatic acid liposomes in the core layer to promote later cell migration and tissue repair, achieving time-sequential drug release that matches the wound healing process. This microcapsule significantly improves the bioavailability and delivery controllability of poorly soluble traditional Chinese medicine active ingredients, and has broad application prospects in the field of wound repair.

The invention provides non-animal-derived carboxyethyl chitosan hydrogel for injection as well as a preparation method and application of the non-animal-derived carboxyethyl chitosan hydrogel, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: modifying bacterial source chitosan with acrylic acid, and coupling the modified bacterial source chitosan with silk fibroin peptide to prepare silk fibroin peptide / non-animal source carboxyethyl chitosan; oligomeric hyaluronic acid is oxidized, cholesterol is modified and used for coating bisabolol, squalene and asiatic acid, and oxidized hyaluronic acid modified lipidosome is prepared; the non-animal-derived carboxyethyl chitosan hydrogel for injection is prepared by mixing the non-animal-derived carboxyethyl chitosan with carbohydrazide modified gelatin, silk fibroin peptide / non-animal-derived carboxyethyl chitosan and oxidized hyaluronic acid, has good moisturizing, antibacterial and hemostatic properties, provides a moist environment for wound surfaces, prevents microbial infection, promotes granulation tissue formation, and has a good application prospect. The drug release rate is changed by matching with the change of the pH value of the skin surface, the wound healing process is shortened, and the high water content of the hydrogel is combined with the moisturizing property of the chitosan to prevent secondary injury caused by wound adhesion.