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Application of asiatic acid in preparation of medicine for preventing hepatitis virus

A technology of asiatic acid, hepatitis virus, applied in the field of medicine

Inactive Publication Date: 2015-07-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the anti-hepatitis C virus effect of Asiatic acid

Method used

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  • Application of asiatic acid in preparation of medicine for preventing hepatitis virus
  • Application of asiatic acid in preparation of medicine for preventing hepatitis virus
  • Application of asiatic acid in preparation of medicine for preventing hepatitis virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Asiatic acid anti-hepatitis C virus experiment

[0018] 1. Experimental drugs, reagents and materials

[0019] 1. Compound: asiatic acid.

[0020] 2. Cell line Huh7, human liver cancer cell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY, 2011; 85(6):2793–2802; Jin Zhong, Pablo Gastaminza, Guofeng Cheng, et al. Robust hepatitis C virus infection in vitro, PNAS, 2005; 102(26):9294-9299).

[0021] 3. Cell line 293T, human embryonic kidney cell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY. 2011; 85(6):2793–2802; Graham, F.L., Smiley, J., Russell, W.C. & Nairn, R.J. Gen. Virol 1977; 36:59–74).

[0022] 4. Cell culture medium, prepared, it contains 10% fetal calf serum, 0.03% glutamine, non-essential amino acid, ampicillin an...

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Abstract

The invention discloses application of asiatic acid in preparation of a medicine for preventing hepatitis virus. The chemical structure of the asiatic acid is as shown in formula I. Through in vitro building a hepatitis c virus (HCV cc) model derived from cell culture, and using an HCV susceptible cell human liver cancer Huh7 cell line, an in-vitro experiment on the anti-HCV activity of the asiatic acid is performed. The result shows that the asiatic acid has obvious anti-HCV activity, particularly is capable of inhibiting the HCV invading the target cell and can be used for preparing the anti-hepatitis c virus medicine. A novel path for the asiatic acid is provided and a novel source for finding the anti-hepatitis c virus medicine is also provided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of asiatic acid in the preparation of medicines for preventing and treating hepatitis viruses. Background technique [0002] Asiatic acid (AA) is a ursane-type pentacyclic triterpene acid, which exists in many plants, such as Centella asiatica. The structure of asiatic acid is as follows: [0003] [0004] Centella asiatica is a commonly used traditional Chinese medicine recorded in the "Chinese Pharmacopoeia". There are about 20 species of Centella L. plants in the world, mainly distributed in tropical and subtropical regions. Asiatic acid is the main component of Centella asiatica triterpene extract, it can also be obtained by hydrolysis of asiaticoside, and it can also be extracted from many other natural products, so the resource is very rich. Asiatic acid has a wide range of pharmacological effects, such as anti-inflammatory skin care, liver and lung p...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P31/14A61P1/16A23L1/30A23L33/11
Inventor 金永生钱汐晶刘洪川陈海生戚中田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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