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499 results about "Triterpenoid saponin" patented technology
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Triterpenoid saponins are triterpenes which belong to the group of saponin compounds. Triterpenes are a type of terpene containing 30 carbon atoms. Triterpenes are assembled from a five-carbon isoprene unit through the cytosolic mevalonate pathway to make a thirty-carbon compound. Some triterpenes are steroidal in nature. Cholesterol, phytosterols and phytoecdysteroids are triterpenes. The triterpenes are subdivided into some 20 groups, depending on their particular structures. Some triterpenoid compounds are found as saponin glycosides which refers to the attachment of various sugar molecules to the triterpene unit. These sugars can be cleaved off in the gut by bacteria, sometimes allowing the aglycone (triterpene) to be absorbed into the bloodstream or to insert into cell membranes.
Highly durable high slump loss resistant no-bleeding concrete pump delivering agent
InactiveCN101244909AImprove appearance qualityEffectively change performanceCarboxymethyl celluloseMetallurgy
The invention relates to a non-bleeding concrete pumping admixture with high durability and high slump retaining, the raw material weight percentage composition of which is: 25 to 45 percent of naphthalene series water reducer, 2 to 6 percent of polycarboxylic series of water reducer, 1 to 4 percent of sodium lignosulfonate, 0.5 to 2 percent of sodium gluconate, 0.2 to 2 percent of triterpenoid saponin, 0.5 to 3 percent of carboxymethyl cellulose, 0.2 to 1 percent of silicon oil, and 40 to 65 percent of water; the non-bleeding concrete pumping aid with high durability and high slump retaining has the advantages of low slump loss and low cost, no bleeding, restraining the shrinkage of concrete, and controlling the fissure of concrete.
Owner:HUNAN CONSTR ENG GRP COR
Liquid cement grinding aid
InactiveCN101318792AEasy to measureChange the production processSodium phosphatesTriterpenoid saponin
The invention relates to a liquid cement grinding aid which can obviously reduce the dosage of trolamine and does not contain urea. The grinding aid comprises the following compositions in weight percentage: 1 to 10 percent of trolamine, 5 to 10 percent of diglycol, 1 to 10 percent of trimeric sodium phosphate, 10 to 30 percent of molasses, 0 to 20 percent of sodium thiosulfate, 0 to 10 percent of air entraining component and the balance being water, wherein the air entraining compositions are triterpenoid saponin air entraining agent, sodium lignin sulfonate or a mixture of the triterpenoid saponin air entraining agent and the sodium lignin sulfonate at any proportion. The invention obviously reduces the dosage of the trolamine, does not contain the urea, lowers product cost and simultaneously facilitates the environmental protection. The sodium thiosulfate has the function of exciting mixed materials of cement and can improve the initial strength and the later strength of the cement, thereby effectively improving the service performance of the cement grinding aid. The triterpenoid saponin air entraining agent and the sodium lignin sulfonate have the action of the auxiliary aided grinding and simultaneously properly entrain air to reduce the water consumption of the cement standard consistence.
Owner:NANJING YONGNENG MATERIALS
Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine
InactiveCN1593436ASignificant effectLower doseOrganic active ingredientsBlood disorderWhite blood cellMedicine
The invention discloses the use of ursane type triterpenoid saponin in preparing medicine for increasing leucocyte and / or platelet which has a general formula (I), the invention also provides a pharmaceutical composition having the action of increasing human leucocyte and / or platelet, which contains ursane type triterpenoid saponin composition having a general formula (I), and pharmaceutically acceptable salts.
Owner:CHENGDU DIAO PHARMA GROUP
Triterpene saponin in camellia seeds, preparation method and medical use thereof
InactiveCN101392015AHigh yieldHigh purityOrganic active ingredientsMetabolism disorderHplc methodAdemetionine
The invention pertains to the field of medical technology and provides triterpenoid saponin in camellia seeds, and a preparation method and medical application thereof. The triterpenoid saponin is shown in a general formula (1), wherein, R1 is hydrogen or oxhydryl or acyloxy; R2 is the hydrogen or the acyloxy; R3 is the hydrogen or the acyloxy; R4 is the hydrogen or the acyloxy; R5 is methyl or methylol or aldehyde group or carboxyl or metheyl carboxyl; R6 is the hydrogen or orglycosyl; the preparation method comprises the following steps: macroporous resins are degreased, extracted by ethanol, decocted in water, desugared and decolored to obtain crude total saponins and then go though an opened ODS chromatographic column and repeated HPLC method to obtain the total saponins of camellia seeds and monomer theasaponin. The triterpenoid saponin compounds in the camellia seeds have the functions of protecting gastric mucosa, being antineoplastic, reducing blood sugar and blood fat and thelike and are used for preparing medicaments or health-care foods having the functions of protecting gastric mucosa, being antineoplastic and reducing blood sugar and blood fat.
Owner:SHENYANG PHARMA UNIVERSITY
Concrete air-entrainer
The preparation method for a concrete air-entrainer comprises: 1) putting the rosin, tallol, triterpenoid saponin and lignin by weight ratio into a reaction kettle to heat and fuse while stirring evenly to prepare the mixed resin A; 2) adding the maleic anhydride and quinone to modify the resin A and obtain the resin B; 3) dripping the carbowax or the mixture of carbowax and pentaerythrite for graft esterification reaction at 180~250Deg to obtain the product C; 4) cooling the kettle temperature to 50~100Deg, adding foam stabilizer D and E; 5) cooling the temperature to 20~95Deg, dripping lye and water to control the solid material in solution as 29~31% and pH value as 9~11, and obtaining the final product. This invention has wide application.
Owner:BOTE NEW MATERIALS TAIZHOU JIANGYAN CO LTD +1
Saponins Derived from Ilex Pubescens and Method of Purifying the same
Two hitherto unreported novel triterpene saponins were isolated in substantially pure form from the root of Ilex pubescens. The chemical structures and some properties of the triterpene saponin fraction have been elucidated to possess anti-inflammatory and analgesic activity. These two novel triterpene saponins and the triterpene saponin fraction may be used as pharmaceutical compositions in humans and mammals in need of such treatment.
Owner:HONG KONG BAPTIST UNIV
Triterpene saponins, methods of synthesis, and uses thereof
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
Owner:SLOAN KETTERING INST FOR CANCER RES
Oleanane triterpene saponin compounds which are effective on treatment of dementia and mild cognitive impairment(MCI), and improvement of cognitive function
InactiveCN101528209AOrganic active ingredientsNervous disorderPharmaceutical drugTriterpenoid saponin
Owner:SK CHEM CO LTD
Cement concrete antifreezer
The invention discloses a cement concrete antifreezer, which comprises the following components in part by weight: 15 to 30 parts of high-performance polycarboxylate water reducer, 20 to 30 parts of low molecular weight alcohol, 0.1 to 0.15 part of triterpenoid saponins, 10 to 30 parts of calcium formate, 2 to 5 parts of organic alkylol amine and 50 to 70 parts of water, wherein the triterpenoid saponins is used for entraining air to form a large number of superfine air bubbles and improve the frost heaving stress of concrete. By the cement concrete antifreezer, the concrete can be subjected to construction at the temperature of between -20 and -30 DEG C.
Owner:河北智胜工程技术有限公司
Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
InactiveUS7727561B2Preventing cerebral agingEnhance memoryBiocideSugar derivativesRheumatismArthritis
Owner:PACIFIC ARROW
Anti-flaming antisepsis leather coating and preparation method thereof
InactiveCN105925099AImprove water resistancePrevent penetrationFireproof paintsAntifouling/underwater paintsDecabromodiphenyl etherTriterpenoid saponin
The invention discloses an anti-flaming antisepsis leather coating which is composed of, by weight, 2-3 parts of hydrous zinc borate, 1-1.5 parts of linoleic acid calcium soap, 0.1-0.2 part of triterpenoid saponin, 0.7-1 part of calcium naphthenate, 1.7-2 parts of polyvinylpyrrolidone, 0.8-1 part of polyacrylamide, 1.6-2 parts of stannous chloride, 0.1-0.13 part of triethanolamine, 190-200 parts of methyl methacrylate, 3-4 parts of lauryl sodium sulfate, 0.1-0.2 part of urotropine, 0.2-0.3 part of ammonium persulfate, 6-7 parts of a 20%-25% formaldehyde solution, 16-20 parts of zinc acetate, 4-7 parts of silver nitrate, 1-2 part of decabromodiphenyl ether and 0.4-1 part of sodium lauryl sulfate. The anti-flaming antisepsis leather coating has a good antibacterial property and excellent moisture permeability and water resistance. Leather coated with the obtained emulsion is good in antibacterial property and excellent in hygiene property.
Owner:CHUZHOU VOCATIONAL & TECHN COLLEGE
Polycarboxylic acid type special additive for lightweight aggregate concrete
The invention relates to a polycarboxylic acid type special additive for lightweight aggregate concrete, which is formed by uniformly mixing 40-50 parts by weight of polycarboxylic acid type water reducing agent, 0.5-6 parts by weight of sodium gluconate, 0.1-0.4 part by weight of triterpenoids saponin, 0.05-0.2 part by weight of defoamer BYK-024 and 0.005-0.02 part by weight of cellulose ether with 50-60 parts by weight of water. The adoption of the special additive can lead lightweight aggregate to be difficult to float, avoid causing great impacts on the working performance of concrete, further avoid increasing the loss of slump constant, well control the performances of workability and homogeneity of the concrete, simplify the production process of the lightweight aggregate concrete, improve the production efficiency, simultaneously improve the construction working efficiency and obtain obvious economic benefits and social benefits.
Owner:GUANGDONG PROVINCIAL CHANGDA HIGHWAY ENG
Liquid cement grinding aid and preparation method thereof
InactiveCN101318791AReduce water consumption for standard consistencyIncrease late strengthTriterpenoid saponinSodium nitrite
The invention discloses a liquid cement grinding aid. The grinding aid consists of the following compositions in weight percentage: 5 to 20 percent of trolamine, 5 to 20 percent of diglycol, 10 to 30 percent of lactose, 1 to 5 percent of triterpenoid saponin air entraining agent, 1 to 5 percent of sodium lignosulphonate and the balance being water. The technical proposal has a function of properly entraining air to reduce the water consumption of the cement standard consistence. The further optimum proposal of the invention is to add sodium nitrite with a mass ration of between 5 and 20 percent based on the technical proposal. The technical proposal can improve the later strength of cement and enhance the corrosion-inhibiting capability of reinforced concrete; meanwhile, the invention also discloses a preparation method of the liquid cement grinding aid.
Owner:NANJING YONGNENG MATERIALS
Anticracking waterproof agent
The present invention discloses one kind of anticracking waterproof agent, which is prepared with anhydrite, aluminum ore powder, lime, naphthalene water reducing agent, magnesium stearate, calcium glyconate, sodium tripolyphosphate, migrating antirust agent, methyl cellulose and triterpenoid saponin powder. The anticracking waterproof agent can raise the compactibility, antiseep function, antirust function and durability of concrete greatly.
Owner:SHANDONG DAYUAN IND
Total triterpene of garden burnet root with anti-inflammatory and analgesic effects and preparation method thereof
InactiveCN101590134ASimple preparation processThe mechanism of action is clearAntipyreticAnalgesicsUlcerative colitisChronic pyonephrosis
The invention belongs to the technical field of medicaments, and provides a method for preparing total triterpene of Chinese medicament garden burnet root. The total triterpene is mainly obtained by performing reflux extraction by 70 percent ethanol, absorbing by a macroporous absorbent resin, using water to wash off impurities, using ethanol solution for elution, then decolorizing an eluent by daiamid powder, using the ethanol solution for elution, and recovering the ethanol through pressure reduction. The total triterpene mainly contains triterpenic acid active components such as arjunic acid, 1beta-euscaphic acid, euscaphic acid, tormentic acid and the like, and triterpenoid saponin active components such as sanguisorbin I, sanguisorbin II, sanguisorbin III, niga-ichigoside, kaji-ichigoside F1 and the like. Experimental results show that the total triterpene has remarkable anti-inflammatory and analgesic effects. The total triterpene has definite action substance basis and action mechanism as well as simple preparation technology, is suitable for industrialized production, can be taken as medicinal raw materials for treating inflammatory diseases such as burn and scald, rectitis, ulcerative colitis, pyelonephritis and the like, and is prepared into clinically acceptable dosage forms such as tablets, capsules, granules or compound preparations according to the prior process.
Owner:SHENYANG PHARMA UNIVERSITY
Detection method for dammarane type four-ring triterpenoid saponin
The invention relates to a method for detecting dammarane tetracyclic triterpenoid saponin and secondary aglycone. The inventive method uses high-efficiency liquid color spectrum-mass spectrum coupled device, wherein the conditions of high-efficiency liquid color spectrum comprises: color spectrum column is ODSC18 column; the column temperature is 20-38Deg. C; the conditions of mass spectrum comprise: the ion source is Turbo Ionspray source; the ejecting voltage is 3000-5000V; the Tem is 250-300Deg. C; the detector uses triplicate four-electrode serial mass spectrum detection and positive ion detection; the scanning method uses multi-reaction detection (MRM); CE is 17-36V; DP is 8-110V; the ion detection comprises: processing impact induce dissociation on the quasi-molecule ion peak of said saponin of first-stage scanning mass spectrum, to obtain the second-stage fragment ion; and uses multi-reaction detection (MRM) scanning method to analyze the ion reaction quantitatively, to represent the blood drug density of monomer saponin and secondary aglycone.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Triterpene saponins, methods of synthesis, and uses thereof
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
Owner:SLOAN KETTERING INST FOR CANCER RES
Compound microorganism silage additive and application to preparation of grain amaranth silage
InactiveCN106173246APromote growthIncrease daily weight gainFood processingClimate change adaptationTriterpenoid saponinDomestic animal
The invention discloses a compound microorganism silage additive and an application to preparation of grain amaranth silage. The compound microorganism silage additive comprises an enzyme and bacteria compound and an amaranth root extract, enzyme in the enzyme and bacteria compound comprises cellulase, hemicellulose, amylase, pectinase, protease and the like, bacteria in the enzyme and bacteria compound comprise a lactobacilli flora, a bacillus thuringiensis group, photosynthetic bacteria, a yeast flora, an actinomycete group, filamentous bacteria and the like, and main components of the amaranth root extract include plant sterol, polysaccharide, oleanolic acid, flavonoid, triterpenoid saponins, organic acid and the like. Compared with a conventional silage additive, the compound microorganism silage additive is good in fermentation effect and palatability. The grain amaranth silage is prepared from the compound microorganism silage additive, the potential advantage of raw materials serving as green feed can be effectively improved, daily gain can be remarkably increased, feed-meat ratio is increased, animal growth is promoted, and the grain amaranth silage can be widely used for livestock and poultry breeding and aquaculture.
Owner:陈日远
Methods of identifying genes for the manipulation of triterpene saponins
The invention provides methods for the isolation of plant genes and their regulatory sequences involved in the biosynthesis of triterpene saponins. Also provided by the invention are genes involved in the biosynthesis of triterpenes, including squalene synthase, squalene epoxidase and beta-amyrin synthase from Medicago truncatula. The identification of triterpene biosynthesis genes allows genetic modification of the content and composition of triterpene saponins in plants for crop improvement and the development of drugs, nutriceuticals and functional foods.
Owner:SAMUEL ROBERTS NOBLE FOUND
Loquat scented tea drink preparing method and its product
InactiveCN1640316AHigh nutritional valueTea extractionUnknown materialsMedicinal herbsAdditive ingredient
The present invention relates to a loquat flower tea beverage product and its preparation method. Said invention uses loquat flower and Chinese medicinal herbs with refreshing effect or tea as raw material and adopts the following processes: soaking the above-mentioned raw materials in boiling water to make extraction, mixing extracted filtrate with sweetening agent and water according to a certain ratio, fine filtering, UHT sterilization and sterile hot-filling so as to obtain the invented product. Said product comprises medicinal components of triterpenoid saponin, etc. and at the same time contains amino acids necessary for human body, nucleic acid, vatmins and various mineral components of Ca, Zn and Fe, etc. Besides, said beverage also has various health-care functions.
Owner:FUJIAN AGRI & FORESTRY UNIV
Method for analyzing effective components of astragali radix and poria preparation with effects of warming spleen and eliminating cysts
The invention relates to a method for analyzing effective components of a drug, in particular to a method for analyzing effective components of an astragali radix and poria preparation with effects of warming the spleen and eliminating cysts. The method comprises the steps as follows: (1) preparation of a control solution; (2) preparation of a test article solution; (3) analysis method of the effective components including flavonoids, phenolic acids, triterpenoid saponins, sesquiterpene glycosides and alkaloids.
Owner:TIANJIN TASLY PHARMA CO LTD
Panax notoginseng saponins ST-4, and medicinal composition, preparation and use thereof
ActiveCN101323635AWith preventionTherapeuticOrganic active ingredientsAntiviralsPANAX NOTOGINSENG ROOTMedicine
The invention discloses a notoginsenoside ST-4 which is a new dammarane type triterpenoid saponin compound shown in the structural formula (I), and a preparation method thereof. The invention also provides applications of the notoginsenoside ST-4 in the preparation of drugs against HSV-1. An HSV-1 strain and HELF (MRC-5) are used as cell experimental subjects to carry out the experiment of antiviral activity of the new compound which is the notoginsenoside ST-4. The results show that the notoginsenoside ST-4 has therapeutical effect for cells infected by HSV-1 and can reduce the infectivity of HSV-1 for MRC-5 cells and be applied to the preparation of drugs against HSV-1.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Salvia miltrorrhiza squalene synthase (SmSQS) gene and encoding protein and application thereof
InactiveCN101928717AIncrease contentHigh substance contentBacteriaTransferasesSalvia miltiorrhizaNucleotide
The invention discloses a squalene synthase gene and an encoding protease and application thereof. The gene is cloned from salvia miltrorrhiza by the homology cloning technology for the first time, and fills a gap of cloning and separating the squalene synthase gene from the traditional precious Chinese herbal medicine salvia miltrorrhiza in China. The provided squalene synthase gene has a nucleotide sequence shown in SEQ ID NO.1, a homologous sequence in which one or more nucleotides are added, substituted, inserted or deleted or a nucleotide sequence of allele thereof and derivatives. The protein encoded by the gene has an amino acid sequence shown in SEQ ID NO.2, or a homologous sequence in which one or more amino acids are added, substituted, inserted or deleted. The provided squalene synthase gene can improve the content of triterpenoid saponin components in plants through biotechnology, and can improve the content of diterpene (tanshinone) substances in the salvia miltrorrhiza by the RNAi technology simultaneously. The squalene synthase gene has good application prospect on research and industrialization of medicinal plant secondary metabolic engineering.
Owner:INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Sea cucumber saponin, preparation method thereof and application thereof in food or medicine
InactiveCN102150851AInhibit weight gainGood for weight lossMetabolism disorderEchinodermata material medical ingredientsOrganic solventHolothurin B
The invention discloses a sea cucumber saponin, a preparation method thereof and the application thereof in food or medicines. A sea cucumber saponin mixture comprises multiple sea cucumber alkyl-type triterpenoid saponins. Preferentially, the sea cucumber saponin mixture comprises holothurin A and / or echinoside A. The sea cucumber saponin mixture can also comprise one or more in holothurin A, holothurin B, echinoside A, echinoside B, 24-dehydroechinoside A and stichoposide E. The sea cucumber saponin can be applied to preparing weight-losing food or medicines, and animal experimental resultsshow that the sea cucumber saponin can be used for remarkably inhibiting weight increment and reducing internal fat accumulation so as to realize a good weight-losing effect. The preparation method of the sea cucumber saponin is low in cost, simpler in steps and less in the pollution of organic solvents on the environment; and through animal experiments, the prepared sea cucumber saponin is proved to have a good weight-losing effect so as to be used for developing safe and effective weight-losing food or medicines.
Owner:OCEAN UNIV OF CHINA
High performance grouting addition for concrete with post-tensioning binding prestressing force
The invention is a special additive for post-tensioned cohesive prestressed concrete structure, prepared of the following components in weight percent: phenyl sulfonate formaldehyde high-grade condensation compound 2-10%, aluminum powder 0.005-0.05%, anhydrite 50-70%, calcined kaoline 10-20%, kaoline 10-20%, linear high-molecular anion polysaccharide 0.05-1.5%, and triterpenoid saponin 0.05-0.1%. It has multiple functions of improving both the rheological property of grouting material and the bulk stability, and after doped, it is unnecessary to compound other materials to effectively improve the rheological property of grout, largely reducing seepage water and avoiding high separation and stratification, and it can effectively compensate shrinkage in plastic and hardening state, enhancing the bulk stability of the grout. The fluidity is basically not lost in 2 hours, the grout is full and dense in the pipeline and has strong adaptability to temperature, and the economic benefits of the technique are obvious. After doped in the cement, it adopts ordinary pressure grouting technique to be able to effectively ensure the grout basal body does not seep water after grouted and the bulk of the grout does not shrink and corrode steels.
Owner:JIANGSU SOBUTE NEW MATERIALS
Method for performing qualitation and quantification on triterpenoid saponin in traditional Chinese medicine by utilizing electrospray protonation pyrolysis-mass spectrum multi-reaction detection mode
The invention discloses a method for performing qualitation and quantification on triterpenoid saponin in traditional Chinese medicine by utilizing an electrospray protonation pyrolysis-mass spectrummulti-reaction detection mode. The triterpenoid saponin can form a stable [M+H]<+> and / or [M+NH4)<+> molecular ion peak in a flow phase containing formic acid or ammonium formate. According to the method disclosed by the invention, a liquid chromatogram-tandem quadrupole mass spectrometry combined instrument is utilized, an electrospray positive ion tandem mass spectrum detection mode is utilized,and mass spectrum parameters of declustering potential, impact energy, impact chamber injection voltage and the like can be quickly optimized in an online mode by a single factor and response surfacemethod; thus, high-strength triterpenoid saponin protonation pyrolysis MRM target ion pairs can be formed; a Q1 calculation formula is [M+H]<+> or [M+NH4]<+>, and a Q3 calculation formula is [aglycone +H-nH2O]<+>. By means of the series of characteristic MRM target ion pairs, the purpose of quick qualitative and quantitative detection on the triterpenoid saponin in the traditional Chinese medicine is realized. The method disclosed by the invention provides an effective technology method for the qualitative and quantitative detection on the triterpenoid saponin in the traditional Chinese medicine and has been successfully applied to content measurement on the triterpenoid saponin of caulophyllum robustum and aralia elata.
Owner:匡海学 +2
Dammarane type triterpenoid saponin compound, preparation method thereof and application thereof in preparation of anti-inflammatory drugs
ActiveCN110746474AReduce expressionGood anti-inflammatory activityOrganic active ingredientsSugar derivativesSilica columnChemical compound
The invention discloses a dammarane type triterpenoid saponin compound, a preparation method thereof and application thereof in preparation of anti-inflammatory drugs. The dammarane type triterpenoidsaponin compound is obtained by separation of cyclocarya paliurus leaves. The preparation method comprises steps of S1, extracting the cyclocarya paliurus leaves by using an alcohol solvent to obtainan extract, wherein the mass ratio of the cyclocarya paliurus leaves to the alcohol solvent is 1: (10-15); S2, separating the extract prepared in the step S1) sequentially by using silica gel column chromatography, MCI gel column choromatography, reversed-phase column choromatography, gel column choromatography and preparation type high performance liquid chromatography to obtain the compound. Thenew compound prepared by the method can suppress release of NO, TNF-alpha, PGE2 and IL-6 in LPS induced RAW264.7 cells, can reduce expression of iNOS, COX-2 and NF-KB / P65 protein, can take on good anti-inflammatory activity and can be used for developing related anti-inflammatory drugs.
Owner:GUANGXI NORMAL UNIV
Compound with wrinkle removing function and application of compound
InactiveCN105287310AImprove repair effectCosmetic preparationsToilet preparationsTriterpenoid saponinBULK ACTIVE INGREDIENT
The invention discloses a compound with a wrinkle removing function. The compound comprises triterpenoid saponin and triterpene acid, wherein the triterpenoid saponin and the triterpene acid are active ingredients from centella. The triterpenoid saponin comprises one or two of asiaticoside and hydroxy asiaticoside, and the triterpene acid comprises one or two of asiatic acid and madasiatic acid. By compounding any one or two of the triterpenoid saponin with any one or two of the triterpene acid, human skin fibroblast secretes type I collagen, and the like can be remarkably improved, the obvious effect of aging skin regeneration is realized, and the compound can be used for the development of wrinkle removing cosmetics.
Owner:JIANGSU LONGLIQI BIOSCIENCE CO LTD
Concrete composite water reducing agent
The invention discloses a concrete composite water reducing agent which is prepared by mixing the following raw materials in parts by weight: 35 to 45 parts of para amino benzene sulfonate-sulfonated acetone-formaldehyde condensates, 25 to 35 parts of Beta-naphthalene sulfonate formaldehyde condensates, 15 to 20 parts of mahogany petroleum sulfonate, 10 to 15 parts of calcium lignosulphonate, 5 to 10 parts of triethanolamine, 8 to 14 parts of sulfonate-type waterborne polyurethane, 6 to 12 parts of zinc phosphate, 5 to 10 parts of ash calcium powder, 5 to 10 parts of polyvinylpyrrolidone, 3 to 6 parts of sodium metasilicate, 4 to 8 parts of coal residue, 3 to 6 parts of triterpenoid saponin, 2 to 4 parts of allylthiourea, 2.5 to 4.5 parts of rhamnolipid, 2 to 3 parts of isooctyl triethoxy silane and 4 to 7 parts of auxiliaries. The adding amount of the water reducing agent is low, i.e., the adding amount of the water reducing agent only accounts for 0.4% to 0.8% of the mass of concrete. The water-reducing rate of the water reducing agent can reach up to 20% to 25%. The water reducing agent has a good plasticizing effect, so that the slump of the concrete is obviously increased, and the cohesiveness and the workability of the concrete are improved, wherein the slump of the concrete can be increased by above 180mm, thereby conforming to the requirement of concrete pumping.
Owner:江苏金海宁新型建材科技有限公司
Method for adopting pH gradient elution method to synchronously separate triterpenoid saponins and licorice flavonoid
The invention relates to a method for adopting a pH gradient elution method to synchronously separate triterpenoid saponins and licorice flavonoid. Eluent taking triterpenoid saponins as a main ingredient and eluent containing licorice flavonoid and other useful ingredients are obtained respectively through preparation of a sample loading solution, pretreatment of macroporous resin, loaded sample adsorption, preheating and application interlayer chromatography for pH gradient elution and adopting sodium carbonate solution, sodium bicarbonate solution or sodium hydroxide solution which are different in alkalinity. Yield of glycyrrhizic acid can be increased by 2-4 times when compared with that of a method taking ethanol solution as eluant, ethanol consumption and consumption caused by ethanol recovery are lowered, yield of glycyrrhizic acid can be increased by more than 60% to greatest extent when compared with that of a normal-temperature elution process, an experimental device which is simple, convenient and easy is provided for non-normal-temperature column separation of temperature-sensitive special ingredients in the field of chemistry, chemical engineering and pharmaceuticals, and the method has popularization value.
Owner:TIANJIN UNIV
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