149results about How to "Therapeutic" patented technology

The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an immunosuppressant, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an immunosuppressant in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an immunosuppressant. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an immunosuppressant and subsequently treated with a dose of an HSP90 inhibitor.

The invention discloses pig-chicken excrement fermenting compound bacteria, a preparation method and a method of utilizing the compound bacteria to ferment and prepare an organic fertilizer. The fermenting compound bacteria comprise the following raw material bacteria: bacillus subtilis, bacillus licheniformis, bacillus coagulans, bacillus megatherium and trichoderma viride. The method for preparing the organic fertilizer comprises the following steps: mixing pig-chicken excrement with crushed straws, adding the fermenting compound bacteria to the mixture according to a dosage of 1-2 Kg per ton, mixing uniformly, the moisture being 50-65 wt%, stacking the mixed raw materials, keeping the temperature at 55-65 DEG C to conduct fermentation, two days after the fermentation, turning the stacked materials for the first time, and then turning the materials once every one or two days, keeping the moisture at 50-65 wt% during the fermentation phase, and after fermentation, obtaining the organic fertilizer with a moisture content of 20-30 wt%. The pig-chicken excrement fermenting compound bacteria disclosed by the invention can be used for fermenting the pig and chicken excrement; compared to the prior art, the method for preparing the organic fertilizer is low in productive investment and production cost, convenient to use, free of odor, and good in the fermentation and decomposing effect.

The invention discloses a probiotics fermentation Chinese medicinal herb composite feed additive used for preventing and treating diarrhea of delivery room suckling piglets and weaning conservation piglets. According to laboratory repeated fermentation experiments and actual using effect of products at a plurality of scaled pig farms, a screened and determined formula is as follows: bacillus cereus inoculum size 2-4%, bacillus subtilis inoculum size 2-4%, Chinese medicinal herb inventory 8-20% (main ingredients of which are the root of Chinese pulsatilla, myrobalan, liquorice and schisandra chinensis), and performing liquid state fermentation and then drying. The probiotics fermentation Chinese medicinal herb composite feed additive used for preventing and treating diarrhea of delivery room suckling piglets and weaning conservation piglets can effectively resolve the problem of piglet diarrhea during scaled pig farming process, effectively improve organism immunity and disease resistance capability of piglets, adjust animal enteric micro-ecology balance and repair intestine mucosa damage, and has the effects of improving weaning piglet daily gain by 6%-12% and feed use ratio by 10%-15% and lowering diarrhea rate by 25%-35%. The probiotics fermentation Chinese medicinal herb composite feed additive used for preventing and treating diarrhea of delivery room suckling piglets and weaning conservation piglets is an ideal green environment-friendly safe and novel feed addictive for replacing antibiotic medicines in diarrhea controlling.

The invention discloses a lactobacillus plantarum UA-416 strain and application thereof, and belongs to the field of functional food microbes. Blanks of lactobacillus plantarum in the effects of lowering uric acid and resisting gout are filled up. According to the lactobacillus plantarum (Lactobacillus plantarum) UA-416 strain provided by the invention, the bacterial strain is already collected inthe China Center for Type Culture Collection (CCTCC) on July 25, 2017; the collection number is CCTCC NO: M2017419. The lactobacillus plantarum UA-416 strain provided by the invention can be used foreffectively lowering the level of blood uric acid, is used for improving the levels of urea nitrogen and creatinine and inhibiting the activity of xanthine oxidase in serum, and has prevention and treatment effects on uricemia or the gout.

The invention relates to a traditional Chinese medicine agricultural fungicide for preventing and treating diseases of vegetables and fruits. The traditional Chinese medicine agricultural fungicide has the characteristics of high efficiency, low toxicity, no public nuisance, no pollution, no toxic or side action, wide antibacterial spectrum and long drug effect to vegetable grey mold, sclerotinia sclerotiorum, downy mildew, colletotrichum lagenarium, fruit ring spot, valsa mali and the like. The traditional Chinese medicine agricultural fungicide has dual functions of preventing and treating various diseases caused by fungi, virus and bacteria and can be widely used for preventing and treating the diseases of vegetables and fruits.

The invention belongs to the technical field of fertilizer, and particularly relates to biological-envelope organic and inorganic microbial fertilizer and a preparation method thereof. The fertilizer is prepared from, by weight, 10-30% of compound microorganism bacterium agents, 10-50% of major elements, 2-15% of medium trace elements, 5-50% of organic matter, 10-40% of calcium carbonate, 10-40% of kieselguhr and 1-10% of lactate, wherein the organic matter comprises one or more of molasses, polyaspartic acid and humic acid. According to the biological-envelope organic and inorganic microbial fertilizer and the preparation method thereof, the compound microorganism bacterium agents are used, so that the microorganism bacterium agents and the major elements can be applied together and the activity of the major elements cannot be lowered, the strain survival rate is high, the chemical fertilizer applying quantity is reduced, soil is improved, the soil fertility is enhanced, the soil ecology environment is improved, and the crop quality and yield are improved.

The invention provides queen bee wine and a brewing method thereof. The queen bee wine contains bees and over 50-degree distilled spirits, wherein the bees can be honeybees and preferably are drone pupae, and can also be bee products such as royal jelly; and the ratio of the bees and / or the bee products to the distilled spirits is 1:2-1:10, preferably 1:3-1:7. The queen bee wine brewed by the method of the invention has the advantages of pure chroma and good mouthfeel.

The invention discloses a compound dihydromyricetin oral aerosol and a preparation method thereof. The aerosol is prepared by mixing the following raw materials in percentage by weight: 98 percent of water extract of dihydromyricetin, 0.05 to 1 percent of deodorant and 0.1 to 1.5 percent of flavoring agent; and the preparation method comprises the following steps of: mixing the water extract of dihydromyricetin, the deodorant and the flavoring agent, uniformly stirring, performing nanofiltration and filling, wherein the deodorant comprises sodium copper chlorophyllin and a tea extract; the flavoring agent comprises natural menthol or 1 to 3 kinds of fruity flavors; and the tea extract is tea polyphenol or catechin. The dihydromyricetin extract is refined through a modern extraction, separation and purification process, and is compounded into the oral aerosol which has the effects of inhibiting bacteria, diminishing inflammation, stopping bleeding, wetting throat, deodorizing and the like and has good mouthfeel without peculiar smell or side effect. Moreover, the oral aerosol has health care effect on the mouth, teeth and throat, and has the effects of preventing and treating pharyngitis, periodontitis, gingivitis, dental ulcer, tooth decay and the like.

The invention discloses a crosslinking agent and a cross-linked polymer as well as a preparation method and an application thereof. The crosslinking agent comprises two or more acetal groups, is small in toxicity, high in stability, safe to use, and can be applied to crosslinking of a plurality of macromolecules or polymers comprising ortho-dihydroxy, meta-dihydroxy, amino, sulfydryl or the combined structural units of the ortho-dihydroxy, the meta-dihydroxy, the amino, and the sulfydryl; the cross-linked polymer is prepared by crosslinking the plurality of macromolecules or polymers comprising the ortho-dihydroxy, the meta-dihydroxy, the amino, the sulfydryl or the combined structural units of the ortho-dihydroxy, the meta-dihydroxy, the amino, and the sulfydryl using the crosslinking agent; a cross-linked material is stable in structure for long time, non-degradable, has good biocompatibility, is simple in preparation method, is low in cost, and is suitable for industrialized production. The cross-linked polymer material can be used as medical health materials, including an embolizing agent and a soft tissue repair filling agent.

The invention relates to aquilaria agallocha leaf tea, as well as a preparation and an application thereof. The aquilaria agallocha leaf tea disclosed by the invention is obtained by languishing, moistening with a liquorice water solution, performing secondary fermentation and baking. The aquilaria agallocha leaf tea prepared by the process disclosed by the invention has the advantages of excellent taste, no bitterness, no toxicity, a certain detoxification role, and double effects of health care and treatment, and can be taken for a long time.

The invention belongs to the department of otolaryngology-head and neck and field of washing and therapeutic apparatus for nasal cavity, which aims at recovering the physiological function of nasal mucosa cilium system. The washing and therapeutic apparatus for nasal cavity comprises a forming system of bionic massage washing stream with adjustable pressure and an intelligent constant temperature system; the core of the main body is controlled by an 892051 single chip microcomputer which also carries out digital control for the temperature of washing stream and for the frequency as well as pressure of the bionic massage washing stream, while the flow rate is controlled and regulated manually. The constant temperature ranges between 35 and 42 DEG C; the frequency of the bionic massage washing stream ranges from 15 to 25 times per second; the pressure of water columns is regulated between 10 and 15 cmH2O(0.98 to 1.47KPa); and the regulation range of the flow rate is fixed between 70 and 100ml per minute. A liquid medicine container and an insulated heating container with heat transfer are combined to be a 'dual-container structure' so as to avoid electric leakage and denaturation and going-bad of the washing liquid medicine after being heated directly. The positive-pressure bionic massage washing stream from the washing and therapeutic apparatus can effectively recover the physiological function of nasal mucosa cilium system and realize the therapy of nasal diseases, thus having wide potential application and high clinical value.

The invention discloses compounds having virus resistance and a composition thereof. The composition comprises one or more of the 13 compounds comprising 6'-O-caffeoyl deacetyl asperulosidic acid methyl ester. The compounds having virus resistance and the composition thereof can be extracted from plants and can also be prepared by synthesis. The composition comprising the compounds having virus resistance can prevent and treat viral infection-caused diseases such as influenza, myocarditis, conjunctivitis, viral pneumonia, encephalitis, leukemia, hepatitis B, hepatitis C, AIDS, genitourinary system infection, EB virus infection, human papillomavirus infection and cytomegalovirus infection. The composition can be prepared into an oral preparation, an injection, a spray, a subcutaneous injection and an anus suppository.

The invention relates to a drug-loaded mesoporous-silica-reinforced dental binder and a preparation method thereof. The binder comprises following components by weight: 40-60% of a resin component, 35-50% of a dilution component, 2-10% of an acid monomer, 0.2-0.5% of a photoinitiator, 0.1-0.3% of a promoter, a trace amount of a polymerization inhibitor and 1-10% of mesoporous silica. The binder has high strength and drug releasing property, and therefore the binder is advantaged by loading and performing controlled releasing of antibacterial agents, anti-inflammatory drugs, hemostatics, etc.. The binder not only has a binding function, but also has certain functions of treating and preventing bacterial infection, and can be used as a dentine binder in clinic.

The invention discloses a toothpaste for stopping bleeding, brightening and refreshing breath and a preparation method thereof. The toothpaste for stopping bleeding, brightening and refreshing breath contains the following materials: olive oil, palm oil, grape seed oil, silica, a universal self emulsified composite emulsifier, a general emulsifier, polyethylene glycol 6000, sodium dodecyl sulfate, sorbitol, a coconut extract, a bletilla striata extract, an Eclipta alba extract, a peppermint extract, a pyracantha fortuneana extract, glycerin, saturated salt water, sodium cyclamate, propylene glycol, distilled water and ethylparaben. Compared with the prior art, the toothpaste contains additional natural plant extracts, has mild property, high safety, powerful effects of removing bad breath, making the mouth breath fragrant and refreshing oral cavity, good foamability and good hemostatic effect; in addition, the toothpaste also has anti-inflammatory effect to prevent inner heat and control inflammation, and can repair mucous membrane tissue wound and enhance the oral mucosal resistance.

The invention relates to a polydopamine-covered magnetic mesoporous silica nano-material as well as a preparation and an application thereof. The polydopamine-covered magnetic mesoporous silica nano-material is prepared by the following steps: ultrasonically dispersing HMSs in a solvent, and adding APTES, so as to obtain HMSs-NH2; then, adding an activated Fe3O4NPs solution, and conducting stirring and centrifuging so as to obtain HMSs-Fe3O4NPs; and then, dispersing the HMSs-Fe3O4NPs in a trimethylaminomethane hydrochloride buffer solution Tris-HCl containing dopamine hydrochloride, implementing open stirring at room temperature, and conducting centrifuging and washing, so that the polydopamine-covered magnetic mesoporous silica nano-material HMSs-Fe3O4 / PD NPs is obtained. The preparationmethod provided by the invention is broad in raw material source, low in cost and easy for operation and separation; the prepared nano-material is uniform in grain size distribution and excellent in water solubility and bio-compatibility, and the nano-material is applied to magnetic resonance imaging and photo-thermal and radiotherapy combined treatment; and a broad application prospect is achieved.

The invention provides a remediation method of alkaline soil, and relates to the technical field of soil improvement. The method comprises the steps of (1), soil preparation; (2), soil loosening agentapplication; (3), soil improving fertilizer application. According to the method, the alkaline soil is restored through the steps of soil preparation, soil loosening agent application, soil improvement fertilizer application and the like to reduce soil alkalinity, improve soil characteristics, loosen soil, increase soil fertility to gradually improve soil alkalinization, soil sterilization and fertilizer addition are conducted while the soil alkalinity is reduced, and the method is a remediation method which has the effects of alkaline soil conditioning agent and value improving and synergism.

The invention relates to a preparation method of a hollow silicon-star gold core / shell nano material for wrapping adriamycin. The preparation method comprises the following steps of dissolving an HMSs (Hollow Mesoporous Silica Sphere), ultrasonically dispersing the dissolved HMSs, adding MPTMS (Mercaptopropyltrimethoxysilane) into the dispersed HMSs, introducing nitrogen into an obtained first mixture, refluxing the obtained first mixture in an oil bath, so as to obtain HMSs-SH (Hollow Mesoporous Silica Sphere-Sulfhydryl), afterwards, dissolving the HMSs-SH in water, adding an Au NPs (Aurum Nanoparticles) solution into an obtained second mixture, agitating the obtained second mixture, so as to obtain an HMSs / Au seed, dissolving the HMSs / Au seed in water, ultrasonically dispersing an obtained third mixture, adding a chloroauric acid solution into the dispersed third mixture, agitating an obtained fourth mixture, adding a silver nitrate solution and an ascorbic acid solution into the agitated fourth mixture, continuously agitating an obtained fifth mixture, so as to obtain an HMSs / Au NSs (Normal Saline Solution), dispersing the HMSs / Au NSs in water, adding an HS-PEG-RGD (Hassium-Polyethylene Glycol-Arginine-Glycine-Aspartic Acid) aqueous solution into an obtained sixth mixture, agitating an obtained seventh mixture, so as to obtain an HMSs / Au-PEG-RGD NSs, afterwards, dispersing the HMSs / Au-PEG-RGD NSs into ultrapure water, adding a DOX*HCL aqueous solution into an obtained eighth solution, agitating an obtained ninth mixture in a light-shielding manner, so that the hollow silicon-star gold core / shell nano material for wrapping the adriamycin is obtained. The nano material provided by the invention owns a specific targeting effect and excellent biocompatibility on a U87MG cell, has a synergistic enhancement effect on chemical therapy and photothermal therapy, and is wide in application prospect.

The invention discloses a production technology for vinegar-soaked walnuts, which belongs to the technical field of brewing of vinegar. The production technology comprises the following process that: mature basic blending vinegar is taken as foundation vinegar; food stuff, comprising 4.6% of walnut kernel, 1.8% of sharpleaf glangal fruit, 1.8% of gastrodia elata and 1.8% of ligusticum wallichii in weight percentage, is soaked in rice wine; then the mature basic blending vinegar accounting for 90% of the total weight is poured into the food stuff to immerse the food stuff; and the immersed mature basic blending vinegar and the food stuff are packaged and fermented. The invention further provides walnut vinegar and the vinegar walnuts produced by the production technology. The production technology is simple, and the walnut vinegar and the vinegar walnuts produced by adopting the technology have the effects of brain fitness, health care and treatment.

The invention relates to a moist towelette capable of preventing and curing rhinitis and a preparation method for the moist towelette and application of the same. The moist towelette consists of a carrier material and liquid medicine, the liquid medicine contains one or a plurality of types of magnolia flower, wrinkled giant hyssop and radix angelicae. The liquid medicine further can contain a pH (potential of hydrogen) regulating agent, an osmotic pressure adjusting agent, a preservative agent, a stabilizing agent, a viscosity regulating agent or surfactant. The invention further relates to the preparation method for the moist towelette and application of the moist towelette in the aspect of preparation of medical materials for preventing and / or curing the rhinitis and relevant symptoms. The moist towelette has the advantages of simplicity in manufacture, convenience in use and effectiveness in treatment.

The invention relates to a compound method of nourishing health wine in the health wine field. The technology proposal goes as follows: schizandra sinensis is 30g, white atractylodes rhizome is 30g, membranous milkvetch root is 30g, indian bread is 30g, rhizoma ligustici wallichii is 30g, licorice root is 30g, white peony root is 30g, Indianmulberry is 30g, nourishing the liver and the kidney is 30g, pulp of dogwood fruit is 30g, asparagus root is 30g, congron is 30g, cyathula officinalis kuan is 30g, tangerine peel is 30g, phellodendron bark is 30g, anemarrhena rhizome is 30g, eucommia ulmoies is 30g, Chinese wam is 30g, rehmannia root is 120g, fox glove is 120g, dwarf lilyturf tuber is 120g, ginseng is 120g, chinese angelica is 90g and barbary wolfberry fruit is 90g. The materials are soaked in the wine with the alcoholic strength of 45-65 for 15 days, and the weight of the wine is between 10-20kg, and invention is gained by filtering the wine which is soaked with materials. The medicine ordinance is that the blood is enriched by the supplementing of the medicine, .the kidney is nourished and the spleen is strengthened and yin and yang is balanced, the medicine has a good treatment effect for the people with weak qi-blood and sexual under-function, at the same time, the cost of the Chinese medicine is low, and the medicine has dual functions of nourishing health care and curing.

The invention provides application of decidua NK cells and decidua NK cell exosomes from cell subsets in preparing drugs and auxiliary therapeutic agents for treating diseases related to infertility.Experiments prove that the exosomes treat endometrium growth disorders by promoting endometrial thickness increasing, improving endometrial cell activity, reducing endometrial cell damage, promoting VEGF expression, maintaining stem features of endometrium matrix cells and stimulating proliferation, so that the pregnancy success rate of endometrium damage model mice is increased to 50-70% from 20%; and the exosomes treat diseases related to maternal-fetal immunologic tolerance disorders by playing a role of immunologic tolerance, reducing a spontaneous abortion rate and improving a help T lymphocyte level. Besides, the exosomes can effectively increase the developmental rate of zygotes fertilized no matter in vitro or in vivo in a multiple mode, meanwhile, an in-vitro fertilization rate, an implantation rate of implantation and a birth rate are also increased, and positive assisting effects on infertility treatment are achieved.

The invention discloses a pyrazolo[3,4-d]pyrimidine derivative that is represented as the formula (I), which has significant growth inhibiting effect, apoptosis promoting effect and cell proliferation alleviating effect on tumor cells, can be used for preventing and / or treating tumor related diseases, and has wide application prospect.

The invention discloses a preparation technique for fungus vinegar with Chinese sorghum, bran, brain coat, sorghum husk, vinegar dreg, vinegar and rice hull as material. Wherein, steaming material with traditional technique, alcoholic fermentating, acetous fermentating, smoking, pouring vinegar, allocating and sterilizing to obtain the Shanxi old mature vinegar; then, preparing fungus vinegar by dipping Shaggy Mane of 20-30 weight share and Giant Clitocybe of 10-20 weight share in base vinegar of 100-150 weight share. Thereby, the product also has health care function, contains a plurality mineral matter, such as Fe, Mn, Cu, Zn, Ca, and Mg, and belongs to the fourth-generation functional spice.

The present invention relates to a Chinese medicine composition with the functions of promoting blood circulation, stopping pain, freeing channels and strengthening sinew and bone for curing various osteopathies fracture, necrosis of femoral head, protrusion of cervical intervertebral disc, prolapse of lumbar intervertebral disc, hyperosteogeny and traumatic injury, etc. Said Chinese medicine is made up by using (by weight portion) 30-50 portions of myrrh, 30-50 portions of frankincense, 60-100 portions of pyrite, 23-40 portions of earthworm, 20-30 portions of wingless cockroach and 20-30 portions of notoginseng.

The invention discloses a moringa flower cake which comprises, in weight percent, 5-50wt% of moringa, 10-60wt% of moringa stem leaf powder, 10-50wt% of flour, 0-20wt% of white sugar, 5-20wt% of lard and 10-20wt% of drinking water. The moringa flower cake is unique in taste, crispy and delicious, the taste of the flower cake is enriched, and the moringa flower cake has the functions of treating hypertension, resisting tumor and treating arthritis and can serve as diabetic healthcare and prevention food. The invention further discloses a preparation method of the moringa flower cake, and the preparation method is simple in step and easy to operate.

The invention discloses a traditional Chinese medicine lotion for treating acne, which is composed of licorice, wild chrysanthemum, angelica, rehmannia glutinosa, rose, plantago seed and acacia fruit, and the weight proportion of each component is calculated as follows: licorice 5- 15 parts, 8-17 parts of wild chrysanthemum, 4-16 parts of angelica, 10-25 parts of rehmannia, 6-14 parts of rose, 5-14 parts of plantago and 8-13 parts of acacia fruit. This product is antibacterial and anti-inflammatory, regulates qi and blood circulation, enhances immunity, is mild in nature, has a fragrant smell, and has dual functions of cleansing and curing. It is the first choice for daily skin care products for acne patients.

The invention relates to Chinese and western medicament compound cream for preventing and treating onychomycosis infected by candidiasis albrican and a preparation method thereof. The cream is yellow cream formed by evenly dispersing mixture of a Chinese medicament extract and a western medicament in a substrate by use of the action of a mixed emulsifying agent. The cream prepared by the method has the advantages of even dispersed main medicament, even and smooth cream, proper viscosity, as long as easily coating on skin, mucous membrane and wound surface, and meeting the requirement of Chinese pharmacopoeia with controllable quality. Pharmacodynamic research proves that the cream has actions of preventing and treating the onychomycosis infected by Candida albicans, and has assistant treatment action on secondary inflammation because of mycotic infection, such as whitlow.

The invention provides a pesticide for preventing and treating the root knot nematode disease, and belongs to the technical field of pesticides. The pesticide for preventing and treating the root knot nematode disease is prepared from, by weight, 10-30 parts of Chinese honeylocust fruits, 10-30 parts of rhizoma arisaematis, 10-30 parts of manyleaf paris rhizomes, 10-30 parts of lilac, 5-20 parts of cortex cinnamomi, 5-20 parts of dianthus caryophyllus, 5-20 parts of officinal magnolia bark, 5-15 parts of holy basil, 3-12 parts of cacumen biotae, 3-12 parts of pinellia ternate, 3-12 parts of banana roots, 1-10 parts of liquorice roots, 1-5 parts of pyroligneous liquid and 1-5 parts of biological fungicide. The biological fungicide is prepared from, by mass, 30%-40% of bacillus cereus and 60%-70% of trichoderma harzianum. The pesticide is obtained through scientific compounding, the raw materials cooperate to prevent and treat the root knot nematode disease, the pesticide effect can reach 97% or above, the effect is stable, and pesticide resistance is avoided.

The present invention relates to an oligosaccharide milk chocolate, and is characterized by that it is composed of (by weight portion) 10-20 portions of oligomeric isomaltose, 10-30 portions of granulated sugar, 25-35 portions of cocoa butter, 10-20 portions of cocoa powder, 10-25 portions of milk powder and 0.5-1.5 portions of lecithin. Said invention is suitable for all people, and has the health-care functions of preventing and curing constipation and raising immunity of human body, and its taste is luscious.

A fat composition o high purity diglyceride containing conjugated linoleic acid and a preparation method thereof are provided. The fat composition comprises 85% to 99.9% by weight of diglyceride containing 0.1 to 80% by weight of conjugated linoleic acid, and the balance being monoglyceride, triglyceride or a mixture thereof. The fat composition can be used in highly functional food additives owing to conjugated linoleic acid having various functions of effecting anti-cancer activity, reducing human body fat, enhancing immunogenicity, and preventing and / or treating diabetes, and can be simply prepared at a high production yield.