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Polydopamine-covered magnetic mesoporous silica nano-material as well as preparation and application thereof

A technology of mesoporous silica and polydopamine, applied in preparations for in vivo experiments, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc., to achieve simple preparation methods, improve radiotherapy effects, and reduce costs. low effect

Active Publication Date: 2018-09-28
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] A search of domestic and foreign literature found that there is no relevant report on the preparation method of magnetic mesoporous silica nanomaterials wrapped with a polydopamine

Method used

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  • Polydopamine-covered magnetic mesoporous silica nano-material as well as preparation and application thereof
  • Polydopamine-covered magnetic mesoporous silica nano-material as well as preparation and application thereof
  • Polydopamine-covered magnetic mesoporous silica nano-material as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation of HMSs-Fe 3 o 4 The specific process of / PD NPs nanomaterials is as follows: figure 1 shown.

[0049] (1) Dissolve 100mg of hollow mesoporous silica (HMSs) in 50mL of ethanol, add propyltriethoxysilane (APTES) dropwise, reflux in 70-80°C oil bath for 4h, and centrifuge at 8500r / min collected, washed 3 times with ultrapure water, and obtained amino-modified hollow mesoporous silica (HMSs-NH 2 ). Zeta potential test results show that the surface of hollow mesoporous silica is successfully modified with amino groups ( figure 2 ).

[0050] (2) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / N-hydroxysuccinimide activated ultra-small ferric oxide Fe 3 o 4 Adding HMSs-NH to NPs solution 2 solution, stirred and reacted for 3 days, collected by centrifugation and washed to obtain ultra-small hollow mesoporous silica nanoparticles HMSs-Fe 3 o 4 NPs. TEM test results show that: Fe with a diameter of about 3nm 3 o 4 NPs loading to HMSs-NH 2...

Embodiment 2

[0053] Take the product obtained in (3) in Example 1 and use ultrapure water to prepare a mother solution with a concentration of 200 μg / mL, then gradiently dilute it to nanomaterials of 100, 50, 20 and 10 μg / mL, and irradiate a series of concentration materials at 808nm laser (output power 1.2W / cm 2 , irradiated for 5 min), and an equal volume of ultrapure water was used as a blank control. HMSs-Fe 3 o 4 / PD NPs nanomaterials temperature rise performance test results show that: within the test concentration range, HMSs-Fe 3 o 4 / PD NPs nanomaterials exhibit excellent photothermal conversion effect, and with the increase of nanomaterial concentration, the temperature increases more obviously ( Image 6 ). At the same concentration (200μg / mL), the output power was 0.2, 0.4, 0.6, 0.8, 1.0 and 1.2W / cm 2 The laser was irradiated for 5 minutes, and the temperature change was observed. The results showed that: with the increase of the output power, the temperature increased mo...

Embodiment 3

[0055] Prepare ultra-small Fe with Fe concentrations of 0, 0.3, 0.6, 1.2 and 2.4mM, respectively 3 o 4 NPs and HMSs-Fe 3 o 4 / PD NPs aqueous solution 1mL, the T of the material at different Fe concentrations was measured by a magnetic resonance imaging analyzer 1 relaxation effect ( Figure 8 ). By calculating the Fe 3 o 4 NPs and HMSs-Fe 3 o 4 r of PD NPs 1 values ​​of 0.64 and 1.27mM, respectively -1 the s -1 . It shows that ultra-small iron oxide nanoparticles have enhanced r after being coated with mesoporous silica 1 relaxation rate, which can be used for enhanced T 1 Magnetic resonance imaging.

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Abstract

The invention relates to a polydopamine-covered magnetic mesoporous silica nano-material as well as a preparation and an application thereof. The polydopamine-covered magnetic mesoporous silica nano-material is prepared by the following steps: ultrasonically dispersing HMSs in a solvent, and adding APTES, so as to obtain HMSs-NH2; then, adding an activated Fe3O4NPs solution, and conducting stirring and centrifuging so as to obtain HMSs-Fe3O4NPs; and then, dispersing the HMSs-Fe3O4NPs in a trimethylaminomethane hydrochloride buffer solution Tris-HCl containing dopamine hydrochloride, implementing open stirring at room temperature, and conducting centrifuging and washing, so that the polydopamine-covered magnetic mesoporous silica nano-material HMSs-Fe3O4 / PD NPs is obtained. The preparationmethod provided by the invention is broad in raw material source, low in cost and easy for operation and separation; the prepared nano-material is uniform in grain size distribution and excellent in water solubility and bio-compatibility, and the nano-material is applied to magnetic resonance imaging and photo-thermal and radiotherapy combined treatment; and a broad application prospect is achieved.

Description

technical field [0001] The invention belongs to the field of core / shell structure nanomaterials and their preparation and application, in particular to a magnetic mesoporous silicon dioxide nanomaterial wrapped by polydopamine and its preparation and application. Background technique [0002] Worldwide, cancer is the leading cause of human death. The current methods of treating cancer include surgery, radiotherapy and chemotherapy, but these traditional treatment methods still have defects. Photothermal therapy is a new technology for treating cancer with precision, controllability and high efficiency. The method selectively irradiates tumor tissue with near-infrared light, causing the tumor area to generate heat, which increases the temperature and leads to the death of cancer cells. The development of new and efficient photothermal therapy materials is of great significance in tumor treatment. At the same time, the clinical synergistic effect of hyperthermia combined wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K41/00A61K9/51A61P35/00
CPCA61K9/5146A61K41/0052A61K49/1857A61P35/00
Inventor 史向阳史梦晗范钰孙文杰彭琛
Owner DONGHUA UNIV
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