77results about How to "Efficient synthesis" patented technology

The invention relates to the technical field of polypeptide biosynthesis, in particular to a method for biosynthesizing acetyl tetrapeptide-5, a composition containing the acetyl tetrapeptide-5 and application of the composition. According to the method, low-cost natural amino acid is used as a substrate, specific aminopeptidase or a mutant thereof is used as a biocatalyst, amino acid ligase and polyphosphatase are combined, and acetyl tetrapeptide-5 can be efficiently synthesized through a one-step enzymatic reaction. Compared with a traditional chemical synthesis method, the method has the advantages of low raw material cost, no use of an organic solvent, mild reaction conditions, high regioselectivity, environmental friendliness, low production cost and the like. The invention also provides a composition containing acetyl tetrapeptide-5 and dipeptide-15, the inhibition effect of the composition on grease secretion is obviously better than that of a single component, and the composition has a synergistic oil control effect under a specific ratio.

The invention discloses a bimetallic asymmetric reduction Schiff base catalyst for synthesizing ethylene carbonate and a preparation method of the bimetallic asymmetric reduction Schiff base catalyst. According to the catalyst, a diamine compound is subjected to selective single-side protection, the imine reduction position is controlled, and a bimetallic active center is introduced; the controllable synthesis of a product for reducing the outer side imine and a product for reducing the inner side imine is realized; the obtained product is recrystallized to obtain a monoimine-monoamine type ligand with a clear asymmetric structure, the monoimine-monoamine type ligand and metal salt form a bimetallic catalyst, and the catalyst generates a synergistic effect through double active sites and shows high catalytic activity and excellent product selectivity.

The invention relates to the technical field of bacterial cellulose preparation, in particular to a composite flora for producing bacterial cellulose and a preparation method thereof, and the preparation method comprises the following steps: screening gluconobacter oxydans, obtaining culture medium preparation materials and preparation tools, preparing a slant culture medium set, preparing an enriched liquid culture medium set, and preparing composite flora mixed inoculation liquid. The method comprises the following steps: preparing a waste tobacco leaf leaching solution, extracting a proportional leaching solution from the waste tobacco leaf leaching solution according to a preset proportion, obtaining a mixed fermentation culture medium based on a preparation tool and the proportional leaching solution, and carrying out inoculation operation on a composite flora mixed inoculation solution by using the mixed fermentation culture medium to obtain a dry cellulose membrane; calculating the yield of the bacterial cellulose based on the dry cellulose membrane, and completing the preparation of the composite flora for producing the bacterial cellulose based on the yield of the bacterial cellulose. The method can be used for scientifically, efficiently and stably preparing the composite flora.

The invention relates to the field of organic synthesis, in particular to a synthesis method of gamma-aminophosphine oxide compounds and derivatives thereof. According to the synthesis method disclosed by the invention, alpha, beta-unsaturated amide, diaryl phosphine oxide or phosphite ester is taken as raw materials, and under the action of acid, the gamma-aminophosphine oxide compound can be rapidly and efficiently synthesized by a one-pot method. The preparation method comprises the following steps of: generating conjugated nitrile positive ions or imine salt intermediates with strong electrophilicity from alpha, beta-unsaturated amide under the activation of acid, converting diaryl phosphine oxide or phosphite ester into strong nucleophilic three-coordination phosphorus species under the action of alkali, and further performing phosphorus-doped Michael addition reaction on the conjugated intermediates to finally generate the gamma-aminophosphine oxide compounds. According to the method disclosed by the invention, diaryl phosphine oxide or phosphite which is cheap, easy to obtain and stable in structural property is used as a phosphorus source, the substrate applicability is wide, and the economic cost is relatively low; in addition, the method realizes synthesis of a target product without participation of a metal catalyst, and is rapid and efficient.

This invention relates to a juglansin and lipoic acid conjugate, its preparation method, and its applications. The juglansin and lipoic acid conjugate is named CL-1. CL-1 exhibits significant protective effects in models of oxidative and inflammatory damage in nerve cells, with a significantly greater reduction in TNF-α and IL-6 levels than the monomeric juglansin and lipoic acid, indicating that CL-1 has superior anti-inflammatory and anti-neural damage effects compared to the monomeric drugs, and possesses the potential to treat neurodegenerative diseases such as Alzheimer's disease. The provided preparation method is designed specifically for the structural characteristics of juglansin and lipoic acid, enabling efficient and large-scale synthesis of CL-1.

The invention belongs to the technical field of biological medicines, and provides a method for synthesizing testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside through two-step enzymatic coupling. Mainly relates to an intermediate compound testosterone 17-O-beta-D-glucosyl-(1-> 4)-beta-D-glucoside for synthesizing the molecule, mutant amino acid and nucleotide sequences of glycosyl transferase OsSGT2 for synthesizing the intermediate, and synthesis application. In addition, the invention also provides an application of the testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside in liver protection.

The application belongs to the technical field of biological medicine, and discloses a synthesis method of aryl F-18 labeled sulfuryl chloride and application of the aryl F-18 labeled sulfuryl chloride in amine compound labeling. The method takes thiophenol derivative as a labeling precursor, obtains F-18 labeled thiophenol intermediate through photocatalytic aryl F-18 fluorination reaction, and then obtains aryl F-18 labeled sulfuryl chloride through N-chlorosuccinimide oxidation chlorination. The obtained aryl F-18 labeled sulfuryl chloride (4-[ 18 F] fluorobenzenesulfonyl chloride) can occur sulfurylization reaction with various amine compounds at room temperature, and the radiochemical conversion rate is as high as 98%. The application is successfully applied to novel synthesis of AMPA receptor PET imaging agent[ 18 F]2 (the conversion rate is 96%, which is much higher than 13% reported in the literature). The application has the advantages of mild reaction condition, high conversion rate and wide substrate application range, and provides an efficient method for innovative preparation of F-18 labeled PET probes.

The invention discloses a pyrazolo [5, 1-a] isoindole derivative as well as a synthesis method and application thereof, and belongs to the technical field of organic chemical synthesis. The invention solves the problems of harsh reaction conditions, limited substrate range and the like of continuous multi-step synthesis of a precursor in the existing pyrazolo [5, 1-a] isoindole compound synthesis process. According to the invention, a polarity reversal strategy is adopted, a cyano group is introduced into 1, 5-enyne to change the electronic characteristics of 1, 5-enyne, diazo, olefin and ethynyl benzene are reacted under mild conditions, two rings and three new chemical bonds are constructed through a series of intermolecular [3 + 2] cycloaddition, intramolecular cycloaddition and elimination reactions, and pyrazolo [5, 5-a]-1, 5-a-phenanthrene is efficiently synthesized. According to the present invention, the 1, 1-a] isoindole derivative has characteristics of good synthesis yield, simple operation of the synthesis method, easily available raw materials, good substrate universality and step economy, and provides the effective strategy for the drug design synthesis.

The invention relates to a method for preparing a hydroxyl naphthaldehyde derivative by using a cobalt complex, which comprises the following step: by taking naphthol and paraformaldehyde as raw materials and the cobalt complex containing an ortho-carborane benzothiazole structure as a catalyst, reacting at room temperature to synthesize the hydroxyl naphthaldehyde derivative. Compared with the prior art, the cobalt complex containing the ortho-carborane benzothiazole structure is applied to the reaction for catalytically synthesizing the hydroxyl naphthaldehyde derivative through the one-pot method, the use equivalent of the catalyst is low, the reaction condition is mild, the substrate universality is high, and the yield is high.

The application discloses a kind of nanoclusters with golgi targeting and its preparation method and application, the nanocluster is zinc sulfide nanocluster, the surface of the zinc sulfide nanocluster is coupled with targeting ligand, the targeting ligand can actively target RA synovial activated macrophage, and can target golgi subcellular organelle, the nanocluster can release H2S gas in inflammatory weak acid microenvironment.The application can realize "inflammatory joint enrichment-> macrophage active uptake-> lysosome escape-> golgi deep anchoring" multi-level precise delivery, release H2S gas in inflammatory weak acid microenvironment, fundamentally reshape intracellular Ca 2+ Steady state, relieve endoplasmic reticulum, golgi and mitochondria triple stress, block inflammatory signal pathway, realize the efficient, safe treatment of RA.

The invention relates to the technical field of biological catalysis, and discloses a mutant enzyme for preparing rebaudioside I. The enzyme is a UGT76G1 mutant, and the mutation points of the mutant are L379V and L126A. The mutated enzyme realizes efficient in-vitro enzymatic synthesis of RI (the conversion rate is 45-60%), the problem of low efficiency (-7%) of an existing path is solved, and the production process has economic feasibility; secondly, the catalytic efficiency is improved by 6-9 times compared with the original level, and the fundamental improvement means that the raw material utilization rate and the production flux are greatly improved; and meanwhile, the seamless connection capability from a laboratory to large-scale production is realized, and a key technical foundation is laid for constructing a stable and controllable industrial production line.

The invention discloses an optical monomer and a preparation method thereof, a resin mixture and application, the molecular structure of the optical monomer takes an aromatic skeleton or an aliphatic skeleton as a center and extends outwards to form a branched chain with a hexa-mercapto functional group, the aromatic skeleton has certain rigidity, the aliphatic skeleton has flexibility, and the molecular structure is uniform. Therefore, the optical monomer has ultrahigh refractive index, high light transmittance and good heat resistance.

The invention discloses a near-neutral synthesis method of high-aluminum-content mesoporous aluminosilicate, which comprises the following steps: firstly, dissolving a template agent in deionized water, and fully stirring to obtain a uniform template agent solution; the preparation method comprises the following steps: uniformly mixing a silicon source with an inorganic salt, and uniformly mixing an aluminum source with a dilute sulfuric acid solution in deionized water to prepare a silicate solution and an aluminum salt solution; synchronously dripping the silicate solution and the aluminum salt solution into the template agent solution to form an aluminosilicate precursor; and performing crystallization, suction filtration, washing, drying and roasting treatment on the precursor to finally obtain the mesoporous aluminosilicate material. In the process of synthesizing the mesoporous aluminosilicate by using the inorganic salt under the near-neutral condition, anions and aluminum ions form a soluble complex (such as Al (HCO3) 2 +), hydrolytic precipitation of aluminum species in a neutral environment is effectively inhibited, and it is ensured that the aluminum element participates in the reaction in an active form; the efficient synthesis of the mesoporous aluminosilicate material with high aluminum content and high order degree is realized.

This invention discloses a method for the selective synthesis of 4-amino-N-(hetero)arylsulfonamide compounds. Using bipyridine as a ligand and nickel as a catalyst, and inexpensive and readily available low-activity (hetero)aryl chlorides and 4-aminobenzenesulfonamides as substrates, 1,8-diazabicycloundec-7-ene and other organic bases are used, along with sodium iodide and other additives. The synthesis of various 4-amino-N-(hetero)arylsulfonamide compounds is achieved through a photo-driven nickel-catalyzed selective C-N coupling reaction of (hetero)aryl chlorides and 4-aminobenzenesulfonamides under an argon atmosphere. This invention features a simple reaction system, convenient operation, mild reaction conditions, and simple post-processing. It exhibits good selectivity for target compounds and high yields, avoiding the problems of complex catalytic systems and poor functional group compatibility caused by the use of traditional expensive metal catalysts and inorganic bases. Therefore, it has significant application value and market prospects.

The application provides a genetically engineered bacterium, a preparation method and application thereof. The genetically engineered bacterium contains an exogenous introduced orfZ gene; the genetically engineered bacterium is selected from luminous bacillus LN01. When the genetically engineered bacterium is fermented by using sucrose and gamma-butyrolactone as precursors, P3HB4HB can be efficiently synthesized, and the content of 4HB in the P3HB4HB is high. The genetically engineered bacterium is expected to be applied to industrialized production of bio-based plastics, and high-efficiency production of P3HB4HB with high content of 4HB is realized. The genetically engineered bacterium has important significance for promoting wide application of biopolyesters and reducing negative influences of petroleum-based plastics on the environment.

This invention discloses the establishment and application of a method for melanin synthesis using *Escherichia coli*, belonging to the fields of genetic engineering, enzyme engineering, and biocatalysis. The invention involves the artificial synthesis of a target gene, the sequence of which is shown in SEQ ID NO:1. Based on this gene sequence, a recombinant vector pCDFDuet-1-melC is constructed and transformed into *E. coli* BL21(DE3) to obtain a recombinant genetically engineered bacterium. A whole-cell catalytic system is then constructed based on this recombinant genetically engineered bacterium for melanin synthesis, achieving a melanin yield of 7.46 g / L. This recombinant genetically engineered bacterium possesses advantages such as high catalytic activity and easy heterologous expression, providing a new pathway for the industrial-scale green production of melanin. The enzyme prepared from this recombinant genetically engineered bacterium exhibits the characteristics of tyrosinase and requires low concentrations of Cu. 2+ It can significantly activate enzyme activity.

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

The invention relates to the technical field of biology, in particular to construction and application of a recombinant strain for synthesizing veratrazine and steroid precursors of the veratrazine, and the steroid precursors comprise squalene, ergosterol, lanosterol, 22R-hydroxy cholesterol, 22R, 26-dihydroxy cholesterol and 22-hydroxy-26-amino-cholesterol. The recombinant strain provided by the invention can efficiently express steroid precursors, for example, the content of lanosterol reaches 172mg / L and is increased by about 170 times compared with that of an original strain, the yield of 22R-hydroxycholesterol reaches 3482.83 mu g / L, the yield of 22R, 26-dihydroxycholesterol reaches 1003.05 mu g / L, veratrazine can be efficiently synthesized, and the yield of veratrazine reaches 265.38 mu g / L.

The application relates to an industrialized preparation method and application of high-purity alpha-amino nitrile. The application belongs to the technical field of fine chemical synthesis. The purpose of the application is to solve the technical problems of low yield and purity, high cost and unsuitability for industrialized production of the existing alpha-amino nitrile synthesis method. The method of the application is as follows: taking imine as a substrate, alpha-amino nitrile is synthesized by reacting with acetone cyanohydrin under the action of an ionic liquid. The method of the application synthesizes a nucleophilic addition cyanyl product of a carbon-nitrogen double bond in one step at room temperature. By selecting the ionic liquid and reasonably controlling the proportioning of various substances, the reaction process is greatly accelerated, the high-efficiency synthesis of alpha-amino nitrile is realized, the purity of alpha-amino nitrile is remarkably improved, the substrate adaptability is good, and the method can be widely applied to the synthesis in the fields of medicines and the like in the industry and the academia.

This invention discloses a method for preparing dehydroevodiamine and its salt, relating to the field of organic synthesis technology. The method involves dissolving evodiamine in an organic solvent and subjecting it to a dehydrogenation reaction under light irradiation to obtain dehydroevodiamine; or dissolving evodiamine in an organic solvent and reacting it with an acid under the action of a catalyst to obtain dehydroevodiamine salt. This invention not only solves the problems of cumbersome processes, long cycles, low production efficiency, and poor environmental friendliness in the extraction and separation of dehydroevodiamine from plants, but also overcomes the defect of demethylation side reactions that easily occur during the synthesis of dehydroevodiamine, achieving efficient synthesis of dehydroevodiamine and its salt.

The application belongs to the technical field of photocatalytic materials, and particularly relates to a surface oxygen vacancy-containing tungsten trioxide and a preparation method and photocatalytic acetonitrile oxidation application thereof. The application adds a sodium tungstate solution dropwise into a hydrochloric acid solution under stirring, stirs after the dropwise addition is completed, centrifuges, washes and dries the precipitate after the reaction is completed, and obtains monoclinic tungsten trioxide; the obtained monoclinic tungsten trioxide is annealed to obtain the surface oxygen vacancy-containing tungsten trioxide. The surface oxygen vacancy-containing tungsten trioxide prepared by the application can photocatalyze the selective oxidation of acetonitrile to formic acid with high activity and high selectivity, realizes efficient degradation of acetonitrile and conversion into formic acid product which also has economic value. The application can degrade acetonitrile wastewater by means of photocatalysis, obtain formic acid product with high added value at the same time, greatly reduce the treatment cost, and the catalyst does not decrease in performance in a catalytic test of five cycles for 30 hours, and has wide application prospects in practical application.

The present application relates to the technical field of petroleum chemical industry, in particular to a kind of heterogeneous synthesis device and method of cyclohexanone oxime.The synthesis device of the present application includes vortex reactor, rotating rod and stirrer;By inserting rotating rod in vortex reactor, annular reaction zone with gap size of 0.5mm-5mm is formed, under the dual action of microscale effect and rotating field, mass transfer resistance is reduced, reaction liquid and catalyst particles are fully contacted, and reaction liquid can be broken into smaller droplets under the shear force provided by rotating field, so that the contact area of oil-water two phases is increased, fully emulsified, uniformly mixed, and the flow distribution of catalyst particles is more uniform, the efficiency of catalytic reaction is improved;At the same time, the concentration distribution of hydrogen peroxide in annular reaction zone is controlled by cooperating with multi-stage feeding mode of hydrogen peroxide, so that the concentration of hydrogen peroxide is matched with the rate of catalytic reaction, thereby improving the utilization rate of hydrogen peroxide, and realizing the efficient synthesis of cyclohexanone oxime.

The invention discloses an insect-resistant and antibacterial pyrrole alkaloid compound and a biosynthetic gene cluster thereof. The structure of the pyrrole alkaloid compound is shown as a formula (I), wherein compounds 2, 3, 4, 14 and 15 are new compounds. The gene cluster of the pyrrole alkaloid compound is disclosed for the first time, and each gene function is confirmed for the first time. PasA and PasD act together to form a pyrrolidone skeleton intermediate 8, and then the compound 8 is converted into a final product 1 by PasB. The invention discloses the inhibitory activity of the compounds on chitinase, lepidoptera pests, namely plutella xylostella and agricultural pathogenic fungi, and a biosynthetic pathway of a lead compound 1 for the first time. The fatality rate of the compound 1 on lepidoptera pest plutella xylostella reaches 100%, the effect of the compound 1 is better than that of DFB, and the compound 1 also has good inhibition potential on agricultural pathogenic fungi. The invention provides a new alternative compound for pesticide development, and lays a solid foundation for realizing green and efficient synthesis of the compound 1.

The application discloses a continuous synthesis method of 2-chloromethyl thiophene and belongs to the technical field of chemical industry. The method comprises the following steps: adding a mixed solution of paraformaldehyde and concentrated hydrochloric acid into a decanter in initial reaction; adding formaldehyde into water phase output from the decanter and heating to 20-30 DEG C during reaction, and then sending to the top of a rectifying column; introducing HC1 gas into the bottom of the rectifying column and controlling the introduction speed to make the top of the rectifying column not discharge HC1 or discharge a small amount of HC1; adding a mixed solution of thiophene and a solvent into the upper part of the rectifying column; the reaction temperature in the rectifying column is 10-30 DEG C, and the reaction liquid at the bottom of the rectifying column is refluxed to the decanter; cooling to -5-0 DEG C in the decanter and carrying out three-phase separation, the organic phase is 2-chloromethyl thiophene mother liquor, and the water phase is continuously output to the rectifying column. The continuous production is realized by combining the principle of gas-liquid reactor design and reaction rectification, and the production efficiency is improved.

The invention relates to the technical field of polymer synthesis and functional materials, in particular to polyvinyl butyral resin as well as a preparation method and application thereof. Through a continuous flow reaction method, reaction parameters are precisely controlled to realize extreme uniformity of a reaction microenvironment, and a specific catalytic system is further combined to realize precise'customization 'of the microstructure of the polyvinyl butyral resin, so that the stereoregularity of the polyvinyl butyral resin is stabilized in a better and narrower'gold' range, and the stability of the polyvinyl butyral resin is improved. The isotactic proportion is 8-10 mol%, the isotactic proportion is 3.5-4.5 mol%, and the beneficial stereoregularity is better. By utilizing the excellent mixing, heat transfer and residence time control capabilities of the continuous flow reaction method, the defects of extensive control of the tacticity of the stereotacticity and poor repeatability of the traditional batch method are overcome, excellent batch repeatability is obtained, and the standard deviation between batches is reduced from more than 1 mol% to less than 0.3 mol%.

This invention relates to the fields of genetic engineering and enzyme engineering, and particularly to glucose dehydrogenase mutants, their preparation methods, and their use in the synthesis of NMNH. The glucose dehydrogenase mutants are obtained by mutation at one or more sites at positions 39, 51, 75, 93, 157, 195, 208, or 236 of the amino acid sequence of the wild-type glucose dehydrogenase. The glucose dehydrogenase mutants of this invention exhibit high catalytic activity and can efficiently catalyze the synthesis of NMNH from NMN. Using the constructed glucose dehydrogenase mutants to catalyze the synthesis of NMNH from NMN, the yield of NMNH can reach 41.2 g / L.

The present application relates to controllable preparation of nanocarbon composite material, and particularly to a method for preparing a welded carbon nanotube@hexagonal boron nitride coaxial heterostructure. A carbon nanotube network is used as a template, and the volatilization amount of boron and nitrogen precursors is controlled during a normal pressure chemical vapor deposition process, so that an amorphous boron nitride welding structure is first grown at the network lap joint, and then hexagonal boron nitride is grown on the surface of the carbon nanotube and the amorphous welding structure, to obtain a welded carbon nanotube@hexagonal boron nitride coaxial hetero-network structure. By changing the volatilization temperature of the boron and nitrogen precursors and the chemical vapor deposition conditions, the microstructure (crystallinity, layer number, curling degree, etc.) of the amorphous welding structure and the coated hexagonal boron nitride is regulated. The welded coated structure can be directly used to construct a film, a fiber, a sponge and other macroscopic bodies, the welding structure at the lap joint in the network can enhance the binding force between carbon nanotube bundles, improve the mechanical properties of the film, and reduce the phonon scattering at the contact, thereby enhancing the heat conduction capacity of the network.

The application belongs to the technical field of hydrogen storage materials, and specifically discloses a rapid preparation method of magnesium borohydride. First, magnesium hydride and rare earth borate (yttrium borate, lanthanum borate, etc.) are uniformly mixed and then subjected to solid-phase ball milling treatment to obtain a solid-phase ball milling product, namely, magnesium borohydride; then, the solid-phase ball milling product is uniformly mixed in a solvent, and high-purity magnesium borohydride can be obtained after purification. The raw material, rare earth borate, used in the application can be synthesized by a simple hydrothermal method, and the process is simple and low in cost. The yield of nearly 50% can be achieved in only 2 hours, which has the industrial production potential of rapidly synthesizing magnesium borohydride and can ensure the high purity of the prepared magnesium borohydride.

This invention discloses a thermophilic recombinant *Yersinia lipolytica* strain producing carotenoids, its construction method, and its applications. The recombinant strain exogenously expresses thermophilic precursor fatty acid desaturase (FAD3) and isocitrate dehydrogenase (IDH2) mutants from *Rhodotorula rubrum*, achieving efficient synthesis at 30°C. Secondly, the metabolic pathway of the recombinant strain is optimized based on a metabolic flux push-pull strategy, overexpressing isopentenyl pyrophosphate isomerase (IDI), farnesyl pyrophosphate synthase (ERG20), phytene dehydrogenase (CarB), and bifunctional phytene synthase (CarRP) to increase precursor throughput. Finally, multiple copies of the genes for astaxanthin synthase (crtS) and cytochrome P450 reductase (crtR) from *Rhodotorula rubrum* are performed to further enhance the carotenoid production capacity of *Yersinia lipolytica*. The thermophilic *Yersinia lipolytica* construction method of this invention is simple, can achieve more efficient carotenoid synthesis at higher temperatures, significantly reduces fermentation costs, and has potential for industrial production.

This invention relates to the use of a transition metal ion-doped graphene oxide membrane catalytic material in the synthesis of 4-phenylmorpholine antibacterial derivatives, belonging to the field of membrane materials and catalytic application technology. The transition metal ion-doped graphene oxide membrane catalytic material retains the intrinsic acidic catalytic sites of graphene oxide nanosheets while introducing transition metal ions that can induce the orientation of reactant molecules. Utilizing the two-dimensional nano-confined channels provided by the interlayer of the graphene oxide membrane and the synergistic effect between the transition metal ions and reactant molecules, rapid and long-lasting catalytic synthesis of 4-phenylmorpholine antibacterial derivatives can be achieved at room temperature (22.3 ± 0.1 ℃) under pressure-driven continuous flow reaction conditions.