215results about How to "Efficient synthesis" patented technology

The invention relates to the technical field of artificial intelligence, in particular to a charging pile construction planning method and system based on artificial intelligence. The method comprises the following steps: acquiring existing power infrastructure data and multi-source heterogeneous data, wherein the multi-source heterogeneous data comprises traffic data, geographic data, vehicle data and charging behavior data; performing time sequence feature extraction on the multi-source heterogeneous data, and performing cross-time scale fusion on different data source features by using a preset hierarchical attention network model to obtain factor weight data; and constructing a long-term charging demand prediction model through a sequence-to-sequence model according to the factor weight data and the multi-source heterogeneous data. According to the site selection method based on the risk minimum set coverage problem, initial site selection scheme data is generated by combining multi-objective optimization of the coverage rate, the service radius and the accessibility, and more scientific charging pile layout is achieved.

The invention relates to the technical production field of metabolic engineering and genetic engineering, and particularly provides a uracil production strain as well as a construction method and application thereof. According to the strain, a uridine kinase gene udk is knocked out on an E.coli W3110 genome, and meanwhile, a T7RNA polymerase gene is integrated; the uridine monophosphate kinase gene pyrH is weakened; the method comprises the following steps: overexpressing a carbamyl phosphate synthetase gene carAB, a ribose phosphate pyrophosphate kinase gene prsA, a pyrimidine-5 '-nucleoside enzyme gene ppnN, UMP phosphohydrolase genes umpH and umpG, a ribonucleoside hydrolase 1 gene rihA and a glutamine synthetase gene glnA; an orotic acid nucleoside monophosphate decarboxylase gene pyrF and an orotic acid ribosyltransferase gene pyrE of wild type bacillus subtilis B.subtilis 168 are introduced in a heterologous manner, so that an orotate nucleoside monophosphate decarboxylase gene pyrF and an orotate ribosyltransferase gene pyrE are obtained. The safe, efficient and low-cost production of the uracil is realized.

The invention discloses an indole sophocarpidine derivative photoaffinity active molecular probe which is formed by connecting an active group and a reactive group, the active group is a sophocarpidine derivative, the reactive group is a substance containing a diaziridine group and an alkyne group, and the chemical formula of the sophocarpidine derivative is as shown in the formula I. The invention further discloses a preparation method of the indole sophocarpidine derivative photoaffinity active molecular probe. After Spodoptera frugiperda Sf9 cells are treated by the indole sophocarpidine derivative photoaffinity active molecular probe for 72 hours, the inhibition rate can reach 86.33%, potential target protein when the sophocarpidine derivative acts on the Sf9 cells can be determined by utilizing the indole sophocarpidine derivative photoaffinity active molecular probe, targeted modification of sophocarpidine is facilitated, and the application range of the indole sophocarpidine derivative photoaffinity active molecular probe is widened. Further, matrine pesticides with excellent insecticidal activity are efficiently synthesized, and agricultural pests are better prevented and controlled.

According to the multi-domain perceptual contrast enhanced computed tomography image synthesis method and system and the electronic equipment, efficient synthesis from non-contrast enhanced images to high-quality contrast enhanced images is successfully achieved by adopting the 3D auto-encoder and the de-noising diffusion probability model, the calculation process is optimized, and the image quality is improved. Due to the introduction of multi-domain perceptual regularization, fine-grained enhancement is carried out on the image at different frequency bands, and the detail expressive force and texture consistency of the synthesized image are remarkably improved. Besides, automation of an image synthesis process is realized through a deep learning framework, manual operation is reduced, processing time is shortened, and a rapid, accurate and reliable technical solution is provided for the field of medical image processing. The technical innovation provides a new path for the generation of the CECT image, and promotes the development of the medical imaging technology.

The invention discloses a synthesis method of an aryl bidentate phosphine compound, which comprises the following steps of: (1) reacting benzene or alkylbenzene with benzyl chloride or 4-alkyl benzyl chloride at 0-100 DEG C for 0.5-5 hours in the absence of oxygen and under the condition of a lewis acid catalyst to prepare a first intermediate; (2) dropwise adding an alkyl lithium reagent into tetramethylethylenediamine at the temperature of-30 to 40 DEG C under the conditions of no water, no oxygen and a solvent, stirring for 1 to 3 hours, dropwise adding the first intermediate into the mixed solution at normal temperature, and reacting for 4 to 20 hours at the temperature of-20 to 40 DEG C to prepare a second intermediate; and (3) under anhydrous and anaerobic conditions, adding diphenyl phosphine chloride into the second intermediate obtained in the step (2), and reacting at-20 to 80 DEG C for 5-60 hours to obtain the aryl bidentate phosphine compound. The synthesis method disclosed by the invention is simple in process, mild in condition and high in product yield, and has a relatively good industrial prospect.

Engineering bacteria for expressing an alpha-glucose phosphate mutase gene, a glucose phosphate mutase gene, a difunctional enzyme glucose phosphate isomerase / mannose 6-phosphate isomerase gene and a mannose 6-phosphate phosphatase gene are used as a whole-cell catalyst, starch or a starch derivative is used as a substrate, phosphate and Mg < 2 + > are added, and the whole-cell engineering bacteria are obtained. A whole-cell catalysis system is constructed, and starch or starch derivatives can be efficiently catalyzed to synthesize D-mannose. According to the method, the D-mannose is prepared through whole-cell catalysis, and the method has the advantages of being low in cost, low in pollution, high in yield and the like and is suitable for industrial production of the D-mannose.

The invention discloses efficient synthesis of ursodesoxycholic acid by improving the positive enzyme activity of 7 beta-hydroxysteroid dehydrogenase through directed evolution, and belongs to the field of biological catalysis engineering. According to the invention, the 7beta-hydroxysteroid dehydrogenase mutant TEAE / F152L / W101N with improved positive reaction activity and improved affinity with a substrate is obtained. Compared with TEAE, the forward enzyme activity of the mutant enzyme is improved by 2.9 times, the reverse activity of the mutant enzyme is reduced by 3.6 times, the catalytic efficiency kcat / Km of the mutant enzyme to 7K-LCA is improved by 4.3 times, and compared with a wild type mutant TEAE / F152L / W101N, the enzyme activity of the mutant enzyme is improved by 206.23 times, and the catalytic efficiency of the mutant enzyme to 7K-LCA is improved by 58.56 times. The invention provides a universal technical platform for directed evolution of hydroxysteroid dehydrogenase, provides an excellent mutant enzyme for biological efficient synthesis of ursodesoxycholic acid, and lays a solid research foundation for efficient and low-cost preparation of ursodesoxycholic acid.

The invention discloses isosorbide type block copolycarbonate as well as a preparation method and application thereof, and belongs to the technical field of organic polymer materials. The problems that isosorbide polycarbonate in the prior art is low in molecular weight, deep in color and luster, fragile in material and the like are solved. The preparation method comprises the following steps: carrying out melt ester exchange polycondensation reaction on dihydric alcohol and isosorbide carbonate serving as raw materials to obtain dihydroxyl-terminated isosorbide ester glycol; rigid amorphous dihydroxyl-terminated isosorbide ester glycol and oligomeric flexible chain dihydric alcohol are connected together, and a molecular chain is reformed, arranged and branched to a certain extent, so that the isosorbide type block copolycarbonate is effectively synthesized. According to the method, the oligomeric flexible chain dihydric alcohol can be effectively introduced to improve the molecular weight and the mechanical property of the isosorbide polycarbonate, so that the problems that the isosorbide polycarbonate is too strong in structural rigidity, fragile in material, deep in color and the like in production and application are solved.

The invention provides a method for constructing planar chiral [2, 2] paracyclophane by cobalt-catalyzed asymmetric carbon-hydrogen bond activation-kinetic resolution, which comprises the following steps: by using a cobalt catalyst, a chiral ligand and an additive, taking a graphite felt electrode as an anode and taking a platinum sheet electrode as a cathode, carrying out racemization on [2, 2] paracyclophane under the condition of direct-current electrolysis, so as to obtain the planar chiral paracyclophane. The preparation method comprises the following steps: carrying out asymmetric carbon-hydrogen bond dehydrogenation coupling / kinetic resolution on 2, 2] paracyclophane formamide and aryl acid, and after the reaction is finished, carrying out corresponding post-treatment to obtain planar chiral [2, 2] paracyclophane formamide and planar chiral oxopara-[2, 2] paracyclophane; according to the method, electrochemical synthesis of planar chiral oxara-[2, 2] paracyclophane is realized through a method for catalyzing asymmetric carbon-hydrogen bond activation by virtue of a crustal high-yield transition metal, a reaction substrate is wide in universality and excellent in stereoselectivity, and a product and a split and recycled raw material can have an excellent ee value (up to gt; 99% ee) and a splitting factor (up to 1057).

The invention relates to the technical field of waste plastic recycling, and discloses a method for converting waste plastic into a high-value MOF material based on a continuous process. The method comprises the following steps: firstly, crushing the waste PET plastic, mixing the crushed waste PET plastic with betaine, and carrying out a heating reaction in ethylene glycol to form a ligand carrier solution; then, alkaline earth metal salt is dissolved in dimethylformamide (DMF) to prepare a metal salt solution, sodium hydroxide (NaOH) is added into the ligand carrier solution at the temperature of 110-130 DEG C, and a turbid ligand salt solution is formed; then, adding the metal salt solution into the ligand salt, and promoting a coordination reaction to obtain a solid-liquid mixture; finally, the MOF material with excellent performance is prepared through the steps of washing, drying and the like. The obtained MOF material has a uniform porous structure and a relatively large specific surface area, and shows a wide potential of high-value utilization of waste PET plastic resource. The method is simple in process and suitable for industrial continuous production.

The invention relates to a methyltransferase gene for catalyzing methylation of resveratrol and application of the methyltransferase gene, and belongs to the technical field of biology. The invention provides a gene of methyltransferase capable of catalyzing resveratrol to generate pinostilbene and pterostilbene. The gene of the methyltransferase is a gene YC26, a gene SS15 or a gene HS97-5. The methyltransferase gene provided by the invention has the advantages of high substrate conversion rate, rich products, high activity and the like, the conversion rate of resveratrol can be increased and synthesis of pterostilbene can be promoted when the methyltransferase gene is combined with other methyltransferase genes to express in different strains, additional addition of expensive methyl donors is avoided, and the production cost is reduced. Only a small amount of substrate resveratrol needs to be added or no substrate resveratrol is added.

The invention provides a key enzyme for synthesizing butanediamine and application of the key enzyme, and belongs to the technical field of bioengineering. The invention provides a gene for synthesizing ornithine decarboxylase. The nucleotide sequence of the ornithine decarboxylase is shown as SEQ ID NO. 7. By further optimizing the reaction system, the butanediamine synthesis capability is improved, and butanediamine can be synthesized more efficiently.

The invention discloses geranyl and geranyl diphosphate synthetase for high yield of beta-carotene and application of the geranyl and geranyl diphosphate synthetase. Specifically, the invention discloses a method for producing beta-carotene, and the method comprises the following steps: overexpressing a CrtE gene, a CarRP gene and a CarB gene in a chassis strain; wherein the CrtE gene is a CrtE gene from Sulfolobus sp. And / or Sulfolobus sp. Acidophilus (Sulfolobus sp. Acidophilus), and the CrtE gene is a CrtE gene from Sulfolobus sp. Acidophilus (Sulfolobus sp. Acidophilus) and / or Sulfolobus sp. Acidophilus. According to the method, the lycopene substrate inhibition effect can be effectively relieved, and the yield of beta-carotene in a chassis strain is effectively increased.

The invention relates to the technical field of polypeptide biosynthesis, in particular to a method for biosynthesizing acetyl tetrapeptide-5, a composition containing the acetyl tetrapeptide-5 and application of the composition. According to the method, low-cost natural amino acid is used as a substrate, specific aminopeptidase or a mutant thereof is used as a biocatalyst, amino acid ligase and polyphosphatase are combined, and acetyl tetrapeptide-5 can be efficiently synthesized through a one-step enzymatic reaction. Compared with a traditional chemical synthesis method, the method has the advantages of low raw material cost, no use of an organic solvent, mild reaction conditions, high regioselectivity, environmental friendliness, low production cost and the like. The invention also provides a composition containing acetyl tetrapeptide-5 and dipeptide-15, the inhibition effect of the composition on grease secretion is obviously better than that of a single component, and the composition has a synergistic oil control effect under a specific ratio.

According to the invention, by optimizing the expression of related genes in the production path of recombinant microorganism 5-hydroxytryptophan and screening and strengthening the gene expression of 5-hydroxytryptophan to extracellular transport protein, the toxicity of product accumulation on thallus growth is greatly reduced. According to the present invention, the efficient synthesis of 5-hydroxytryptophan using glucose or glycerol as the carbon source is achieved, the 5-hydroxytryptophan is co-produced under the action of tryptophan hydroxylase by adding a part of tryptophan in the fermentation system as the substrate, and the conversion from the low-value carbon source to the high-added-value product is achieved.

The invention relates to a T7RNA polymerase mutant and application thereof. Compared with a wild type T7RNA polymerase, the T7RNA polymerase mutant has the following mutations: P266L, S430P, N433T, S633P, Y639F, V689Q, V783M, F849I and F880Y, and the T7RNA polymerase mutant has the following mutations: P266L, S430P, N433T, S633P, Y639F, V689Q, V783M, F849I and F880Y. Or, on the basis of the mutation, at least one of the following mutations: S43Y, G47A and S641A can also exist. The T7RNA polymerase mutant provided by the invention can be used for identifying and doping one or more nucleotide substrates in rNTPs, 2 '-F-dNTPs and dNTPs, so that a single-stranded DNA molecule, a fluorinated RNA molecule and a perfluorinated DNA molecule are efficiently synthesized in vitro.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a method for preparing peroxy acid. The method comprises the following steps: S1, carrying out reaction on organic acid, hydrogen peroxide, a catalyst and a solvent in a first pre-reactor, and introducing a product obtained by the reaction into a first reactive distillation tower for reaction; s2, reacting the product obtained in the step S1 in a second pre-reactor, and introducing the product into a second reactive distillation tower for reaction after the reaction is finished; s3, the product obtained in the step S2 and a stabilizer are subjected to a reaction in a mixer, the stabilizer is a nitrogen-containing alkaline compound, lone pair electrons exist on N atoms, and the catalyst is selected from one or two or more of sulfuric acid, nitric acid, isopolyacid and heteropolyacid. By adopting the method to prepare the peroxy acid solution, the selectivity and yield of peroxy acid can be improved, and the total conversion rate of hydrogen peroxide is gt; the selectivity of peroxy acid is gt; meanwhile, caprolactone is prepared by using the peroxy acid to dissolve cyclohexanone oxide liquid, and the conversion rate of cyclohexanone is gt; the selectivity of the obtained caprolactone is gt; 85%.

The invention discloses a method for preparing a silicon monoxide material through photovoltaic silicon waste regeneration and application, and belongs to the field of secondary resource recycling. According to the method, photovoltaic cutting waste silicon sludge and silicon dioxide are taken as raw materials, silicon monoxide (SiO) gas is generated through vacuum disproportionation reaction, and a uniform high-purity SiO material is formed by controlling the temperature of a condensation thermal field. According to the preparation method, by utilizing the characteristics of fine granularity, high purity and high activity of the cut waste silicon sludge, the conversion efficiency and uniformity of the SiO product can be remarkably improved, and the SiO product obtained by the preparation method has the characteristics of high purity, good uniformity and the like, and has excellent long-cycle stability when being used as the anode of the lithium ion battery. According to the preparation method, the waste silicon powder is directly regenerated to prepare the SiO product, so that the production cost of SiO can be reduced, value-added cyclic utilization of the waste silicon powder can be realized, the raw material cost is low, the process operation is simple, the practicability is high, and meanwhile, the preparation method also has huge economic benefits and wide application prospects.

The invention discloses a bimetallic asymmetric reduction Schiff base catalyst for synthesizing ethylene carbonate and a preparation method of the bimetallic asymmetric reduction Schiff base catalyst. According to the catalyst, a diamine compound is subjected to selective single-side protection, the imine reduction position is controlled, and a bimetallic active center is introduced; the controllable synthesis of a product for reducing the outer side imine and a product for reducing the inner side imine is realized; the obtained product is recrystallized to obtain a monoimine-monoamine type ligand with a clear asymmetric structure, the monoimine-monoamine type ligand and metal salt form a bimetallic catalyst, and the catalyst generates a synergistic effect through double active sites and shows high catalytic activity and excellent product selectivity.

The present invention relates to the field of genetic engineering technology, and in particular to a CsCCD2 mutant, gene and application of saffron, and a recombinant model organism for producing crocetin. The protein sequence of the CsCCD2 mutant of the present invention is compared with the protein sequence of the wild-type CsCCD2, and it has a 14-amino acid deletion at the second amino acid. The present invention improves its binding ability and cleavage ability with zeaxanthin by protein modification of the CsCCD2 enzyme derived from saffron, and has the advantages of being more environmentally friendly and low-cost for the biosynthesis of crocetin, and provides a feasible method for the production of crocetin. And the efficiency of the engineering bacteria provided by the present invention in producing crocetin is high, and the concentration of crocetin can reach 1.20mg / g after fermentation for 72h.

The invention belongs to the technical field of genetic engineering, and particularly relates to construction and application of genetically engineered bacteria for producing PQQ. According to the invention, Escherichia coli K-12 MG1655 is used as a chassis cell, and genes pqqA and pqqBCDE, which are used for controlling the source of Gluconobacter oxydans 621H by a PT7 promoter, are integrated on a genome; performing copy number and promoter optimization on the pqqA gene, the pqqB gene, the pqqC gene, the pqqD gene and the pqqE gene in the pqq gene cluster; the method comprises the following steps: overexpressing and coding a metalloproteinase subunit TldD gene tlDd, and knocking out a coding DNA (Deoxyribose Nucleic Acid) to combine with a transcription dual-regulatory factor IscR gene iscR; enhancing the coding of the outer membrane protein A gene ompA; overexpressing a quinone protein glucose dehydrogenase coding gene gcd; the S-adenosylmethionine synthetase coding gene metK is integrated, and the efficient synthesis of the PQQ is realized through the method.

The invention relates to the technical field of bacterial cellulose preparation, in particular to a composite flora for producing bacterial cellulose and a preparation method thereof, and the preparation method comprises the following steps: screening gluconobacter oxydans, obtaining culture medium preparation materials and preparation tools, preparing a slant culture medium set, preparing an enriched liquid culture medium set, and preparing composite flora mixed inoculation liquid. The method comprises the following steps: preparing a waste tobacco leaf leaching solution, extracting a proportional leaching solution from the waste tobacco leaf leaching solution according to a preset proportion, obtaining a mixed fermentation culture medium based on a preparation tool and the proportional leaching solution, and carrying out inoculation operation on a composite flora mixed inoculation solution by using the mixed fermentation culture medium to obtain a dry cellulose membrane; calculating the yield of the bacterial cellulose based on the dry cellulose membrane, and completing the preparation of the composite flora for producing the bacterial cellulose based on the yield of the bacterial cellulose. The method can be used for scientifically, efficiently and stably preparing the composite flora.

The invention discloses a supported polymeric ionic liquid based on [TMGH] Br dication and a preparation method and application thereof. According to the method, five starting raw materials which are easy to obtain are used, the supported polymeric ionic liquid based on [TMGH] Br dication is prepared through a one-pot method, and cyclic carbonate can be efficiently synthesized under the conditions of the temperature of 60 DEG C, normal pressure, no solvent and no cocatalyst. The polymeric ionic liquid is simple and efficient in synthesis method, has multiple active centers and high ion density, shows excellent catalytic activity and has good cycle performance.

The invention relates to the field of organic synthesis, in particular to a synthesis method of gamma-aminophosphine oxide compounds and derivatives thereof. According to the synthesis method disclosed by the invention, alpha, beta-unsaturated amide, diaryl phosphine oxide or phosphite ester is taken as raw materials, and under the action of acid, the gamma-aminophosphine oxide compound can be rapidly and efficiently synthesized by a one-pot method. The preparation method comprises the following steps of: generating conjugated nitrile positive ions or imine salt intermediates with strong electrophilicity from alpha, beta-unsaturated amide under the activation of acid, converting diaryl phosphine oxide or phosphite ester into strong nucleophilic three-coordination phosphorus species under the action of alkali, and further performing phosphorus-doped Michael addition reaction on the conjugated intermediates to finally generate the gamma-aminophosphine oxide compounds. According to the method disclosed by the invention, diaryl phosphine oxide or phosphite which is cheap, easy to obtain and stable in structural property is used as a phosphorus source, the substrate applicability is wide, and the economic cost is relatively low; in addition, the method realizes synthesis of a target product without participation of a metal catalyst, and is rapid and efficient.

This invention relates to a juglansin and lipoic acid conjugate, its preparation method, and its applications. The juglansin and lipoic acid conjugate is named CL-1. CL-1 exhibits significant protective effects in models of oxidative and inflammatory damage in nerve cells, with a significantly greater reduction in TNF-α and IL-6 levels than the monomeric juglansin and lipoic acid, indicating that CL-1 has superior anti-inflammatory and anti-neural damage effects compared to the monomeric drugs, and possesses the potential to treat neurodegenerative diseases such as Alzheimer's disease. The provided preparation method is designed specifically for the structural characteristics of juglansin and lipoic acid, enabling efficient and large-scale synthesis of CL-1.

The invention belongs to the technical field of biological medicines, and provides a method for synthesizing testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside through two-step enzymatic coupling. Mainly relates to an intermediate compound testosterone 17-O-beta-D-glucosyl-(1-> 4)-beta-D-glucoside for synthesizing the molecule, mutant amino acid and nucleotide sequences of glycosyl transferase OsSGT2 for synthesizing the intermediate, and synthesis application. In addition, the invention also provides an application of the testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside in liver protection.

The invention provides an efficient synthesis method of biomass calcium formate. Biological calcium carbonate is ground into powder, the powder and formic acid are subjected to a chemical reaction, under the action of organic matter, generation of a large amount of regular orthogonal-beta calcium formate is induced, the crystal form is P41212, and the yield of calcium formate is greatly increased. The method for synthesizing calcium formate provided by the invention has the advantages of simple and easily available raw materials, low production cost, high synthesis yield, catalyst induction of the raw materials and the like, the synthesis process is efficient and environment-friendly, no pollutant is generated, and the economic profit and sustainability of the process are further improved. The synthesis process does not pollute the environment, a by-product carbon dioxide is generated in the reaction process, and the carbon dioxide can be reused. The generated calcium formate is of a very regular octahedral structure, and has important reference significance for efficiently synthesizing the calcium formate in industry.

The application belongs to the technical field of biological medicine, and discloses a synthesis method of aryl F-18 labeled sulfuryl chloride and application of the aryl F-18 labeled sulfuryl chloride in amine compound labeling. The method takes thiophenol derivative as a labeling precursor, obtains F-18 labeled thiophenol intermediate through photocatalytic aryl F-18 fluorination reaction, and then obtains aryl F-18 labeled sulfuryl chloride through N-chlorosuccinimide oxidation chlorination. The obtained aryl F-18 labeled sulfuryl chloride (4-[ 18 F] fluorobenzenesulfonyl chloride) can occur sulfurylization reaction with various amine compounds at room temperature, and the radiochemical conversion rate is as high as 98%. The application is successfully applied to novel synthesis of AMPA receptor PET imaging agent[ 18 F]2 (the conversion rate is 96%, which is much higher than 13% reported in the literature). The application has the advantages of mild reaction condition, high conversion rate and wide substrate application range, and provides an efficient method for innovative preparation of F-18 labeled PET probes.

The invention provides a method for preparing high-yield allyl alcohol, comprising mixing acetaldehyde, an organic chloride and a phase transfer catalyst, reacting under alkaline conditions, extracting to obtain an aqueous phase; sequentially dehydrating and acidifying the aqueous phase and performing reduced pressure distillation to obtain acrylic acid; finally, mixing the acrylic acid with a reducing agent for reaction, and performing atmospheric distillation to obtain allyl alcohol. The invention selects acetaldehyde and an organic chloride capable of synthesizing carbene as raw materials, and fully and effectively converts them into a target product under the action of a phase transfer catalyst and a carbene substrate, thereby avoiding the generation of by-products. At the same time, molecular distillation technology is used to make the reaction and separation more efficient, and the obtained allyl alcohol has high purity and high yield. The preparation method is carried out under normal pressure and relatively low temperature, and no harmful waste is generated during the reaction. The method has the characteristics of simple process, low energy consumption, economy, environmental protection, and suitability for industrial large-scale production, and overcomes the technical defects in the traditional allyl alcohol preparation method, thereby providing a new method for the industrial production of allyl alcohol.

The invention discloses a bio-based graded porous adsorbent as well as a preparation method and application thereof, and belongs to the technical field of material science and environmental engineering. The preparation method comprises the following steps: S1, dissolving metal salt in a CaCl2 solution, and carrying out ultrasonic treatment to obtain a metal salt solution I; s2, adding terephthalic acid into deionized water, then adding NaOH, carrying out ultrasonic treatment, adding the bio-based natural polymer after complete dissolution, and continuously stirring for 2 hours to obtain a ligand solution II; s3, slowly dropwise adding the ligand solution II obtained in the step S2 into the metal salt solution I, standing and aging, centrifugally collecting precipitates, washing, freeze-drying and grinding to obtain the bio-based graded porous adsorbent. The bio-based hierarchical porous adsorbent prepared by the invention shows excellent adsorption performance on various organic dye molecules, and has important application potential in the aspect of treating industrial wastewater and printing and dyeing wastewater.