57 results about "Enyne" patented technology

The application provides a kind of sodium sulfide nine hydrate and activated olefin / acetylene preparation polyether and its method, belong to sulfur-containing polymer technical field.The structural formula of polyether in the application, R 1 And R 2 Independently be substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;The number of carbon atoms of the alkyl is 1-10, the number of carbon atoms of alkoxy is 1-10, the number of carbon atoms of aryl is 1-30, the number of carbon atoms of heteroaryl is 3-30;Substituted alkyl and substituted alkoxy independently are one or more;N is an integer of 2-4000.The application is used as sulfur source sodium sulfide nine hydrate, under the condition of no metal catalyst, polyether is synthesized by polymerization reaction;Reaction condition is mild, reaction is efficient, economic and environmental protection, meet the current green production concept and can avoid the use of dangerous reagent.

This invention discloses a method for preparing sulfonamide-modified benzo[a]fluorene-5-one derivatives, using 1,7-enyne and N Using sulfonylaminopyridine salts as raw materials, a series of sulfonated benzo[a]fluorene-5-one compounds were successfully synthesized by catalyzing the sulfonation / cyclization tandem reaction of 1,7-enynes under photocatalytic conditions. This method has excellent functional group tolerance and high economic applicability.

Provided are an enyne compound and a use thereof. Specifically, provided are a compound represented by Formula I, or a pharmaceutically acceptable salt thereof, functional groups being as defined in the text. Also provided are a method for preparing the compound of Formula I, a pharmaceutical composition containing the compound, a use thereof as a therapeutic, in particular a use thereof as an SMARCA2 inhibitor, and a use thereof in the preparation of a medicament for preventing and / or treating cancer.

The invention discloses a tetra-coordinated boron-oxygen heterocyclic compound and a preparation method thereof, and belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry. The method comprises the following steps: by taking a bis (pentafluorophenyl) borane dimethyl sulfide complex [(C6F5) 2BHSMe2] as a boron source, firstly carrying out hydroboronation reaction on the bis (pentafluorophenyl) borane dimethyl sulfide complex [(C6F5) 2BHSMe2] and an eneyne compound to generate a three-coordination alkenyl boron dienophile intermediate in situ, and then carrying out reverse electron demand Diels-Alder reaction on the three-coordination alkenyl boron dienophile intermediate and an acetylenic ketone compound to synthesize a series of tetra-coordination boron-oxygen heterocyclic compounds. The method has the advantages of mild reaction conditions, good selectivity, high yield, wide substrate application range, environmental friendliness, simplicity and convenience in operation and the like, opens up a new way for synthesis of the tetra-coordinated organoboron compound, and has higher application value and social and economic benefits.

Inhibitors of hydrogen embrittlement, which can include a terminal alkene or a terminal alkyne, such as an enyne are described. Compositions, such as treated fluid compositions, that include an inhibitor of hydrogen embrittlement, such as a terminal alkyne or a terminal alkene are described herein. Methods of treating a fluid, generating energy, transporting, or storing a treated fluid are also provided.

An oxidation strategy of benzyl C-H compounds, halides, alkenes, alkynes or alcohols mediated by butanedione, which can efficiently prepare alcohol, aldehyde, ketone or carboxylic acid compounds by using 1o, 2oor 3obenzyl C-H compounds, halides, alkenes, alkynes or alcohols as raw materials, adding butanedione, acid and solvent, and then irradiating under oxygen condition by visible light. The method provides an oxidation method for many natural products, drugs and materials, which does not need traditional oxidants, does not use transition metal catalysts, uses cheap butanedione as photosensitizer, uses water as solvent, and efficiently oxidizes 1o, 2oor 3obenzyl C-H compounds, halides, alkenes, alkynes or alcohols to prepare alcohol, aldehyde, ketone and carboxylic acid compounds under the induction of visible light. The whole production process is green, low-cost, wide-substrate applicability, high-yield, simple operation, no explosion risk, and has very significant advantages compared with the previous production process.

The invention discloses a pyrazolo [5, 1-a] isoindole derivative as well as a synthesis method and application thereof, and belongs to the technical field of organic chemical synthesis. The invention solves the problems of harsh reaction conditions, limited substrate range and the like of continuous multi-step synthesis of a precursor in the existing pyrazolo [5, 1-a] isoindole compound synthesis process. According to the invention, a polarity reversal strategy is adopted, a cyano group is introduced into 1, 5-enyne to change the electronic characteristics of 1, 5-enyne, diazo, olefin and ethynyl benzene are reacted under mild conditions, two rings and three new chemical bonds are constructed through a series of intermolecular [3 + 2] cycloaddition, intramolecular cycloaddition and elimination reactions, and pyrazolo [5, 5-a]-1, 5-a-phenanthrene is efficiently synthesized. According to the present invention, the 1, 1-a] isoindole derivative has characteristics of good synthesis yield, simple operation of the synthesis method, easily available raw materials, good substrate universality and step economy, and provides the effective strategy for the drug design synthesis.

The invention belongs to the technical field of organic synthesis, and discloses a preparation method for trifluoromethylation of a 1, 6-enyne substrate. The preparation method comprises the following steps: in a protective gas atmosphere, mixing a 1, 6-eneyne substrate, NaSO2CF3, an oxidant, N-bromosuccinimide and an organic solvent, heating to react, cooling, separating an organic phase, drying and purifying to obtain a product after trifluoromethylation of the 1, 6-eneyne substrate, the organic solvent is selected from any one of dimethoxyethane and 1, 2-dichloroethane. The preparation method is mild in reaction condition, simple and convenient to operate, good in substrate applicability, good in substrate selectivity in reaction and high in target product yield, and a new way is provided for trifluoromethylation of the 1, 6-eneyne compound.

The invention discloses a novel porous carbon / ordered carbon composite material and a preparation method and application thereof, and the method comprises the following steps: S1, dispersing porous carbon to form a porous carbon dispersion liquid; s2, adjusting the porous carbon dispersion liquid to be acidic, then adding a micromolecule monomer and an initiator into the porous carbon dispersion liquid, promoting in-situ polymerization coating of the micromolecule monomer, and forming a layer of ordered carbon precursor on the surface of the porous carbon; s3, performing solid-liquid separation, calcining the porous carbon of which the surface is coated with the ordered carbon precursor in a protective atmosphere, and carbonizing the ordered carbon precursor into an ordered carbon layer coated on the surface of the porous carbon to obtain a porous carbon / ordered carbon composite material; wherein the micromolecule monomer is selected from one or more of an alkene / alkyne micromolecule monomer, a styrene micromolecule monomer, an acrylate micromolecule monomer, a bifunctional acid / alcohol micromolecule monomer, a cyclic micromolecule monomer, a polymer micromolecule monomer, a biocompatibility micromolecule monomer, a crosslinking micromolecule monomer and a natural source micromolecule monomer.

This invention relates to a method for synthesizing aromatic carbon-10 sulfur-containing compounds from isoprene. Specifically, using disulfide, isoprene, and 2-methyl-1-buten-3-yne as raw materials, aromatic carbon-10 sulfur-containing compounds are constructed under cobalt catalyst and iodine tandem catalysis. This invention has the following advantages: the raw materials are simple and readily available, the synthesis is simple, it is environmentally friendly, the conditions are mild, and it has high atom economy. The compounds obtained from the bulk chemical isoprene have structures similar to natural terpenes and represent an important class of terpenes.

The application discloses a synthesis method of (2E,4Z)-2,4-decadienoic acid ethyl ester, and belongs to the technical field of perfume synthesis. The method comprises the following steps: 3-octyn-1-ol is subjected to the oxidation of Akira Yoshide to obtain 2-octynal; after the aldol condensation and decarboxylation reaction of 2-octynal and malonic acid, E-dec-2-en-4-ynoic acid is obtained; the esterification reaction of the obtained carboxylic acid is carried out to obtain E-dec-2-en-4-ynoic acid ethyl ester; and the enynoic acid ester is subjected to cis-reduction to obtain (2E,4Z)-2,4-decadienoic acid ethyl ester. The synthesis method has the advantages of simpler operation, less waste, high selectivity, guaranteed yield and product quality, and is more suitable for industrialized scale production.

The invention discloses a method for synthesizing 1, 3-conjugated diene carboxylate by palladium-catalyzed conjugated eneyne hydrogen esterification reaction, and belongs to the field of organic synthesis. Under the protection of nitrogen, conjugated eneyne and formic acid aryl ester are used as raw materials and react in an organic solvent system containing a palladium catalyst and a ligand to obtain the 1, 3-conjugated diene carboxylic ester. The one-step method is adopted, under the combined action of the ligand and the palladium catalyst, preparation and synthesis of the 1, 3-conjugated diene carboxylic ester with good selectivity are achieved, the system is simple, and the target product can be obtained without additional treatment. The method is easy to operate, mild in condition, wide in substrate range and good in functional group compatibility, different types of conjugated enyne show good tolerance, amplification is easy, atom economy is high, and the method is superior to a traditional synthesis method in multiple aspects.

The invention discloses a method for preparing imide through a multi-component reaction of olefin and 1, 3-eneyne with peroxybenzoate and acetonitrile under the catalysis of copper, which is characterized by comprising the following steps: in the presence of a copper catalyst, a ligand and peroxyaryl carboxylic acid tert-butyl ester and under the heating condition, carrying out a reaction on 1, 3-eneyne and 1, 3-eneyne in an acetonitrile organic solvent to prepare the imide. Reacting the compound in the formula (1) with a compound in a formula (2) and acetonitrile to generate imides in a formula (3) and a formula (4); and reacting the compound in the formula (5) with the compound in the formula (2) and acetonitrile to generate imides in a formula (6) and a formula (7). The preparation method provided by the invention can be suitable for various aryl olefins, drug-derived olefins, alkyl-substituted 1, 3-enyne, aryl-substituted 1, 3-enyne and silicon-substituted 1, 3-enyne, and has the advantages of simple and easily available substrate and wide universality. The method has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide reaction substrate application range, easy reaction amplification, mild reaction conditions and the like, and can realize industrial production and application.

The invention discloses a method for synthesizing functional pyrrole through photocatalysis of N-arylglycine and 1, 3-eneyne. According to the method, N-arylglycine is decarboxylated through photocatalysis to form an alpha-amino alkyl free radical, and the free radical and 1, 3-eneyne are subjected to free radical addition, cyclization and oxidative aromatization reaction to construct polysubstituted pyrrole. Pyrrole serves as a heterocyclic compound with great importance, widely exists in numerous drug compounds and bioactive molecules, shows electronic characteristics with great prospects in organic photovoltaic devices (OPVs) and organic field effect transistors (OFETs), is also a key structural unit in synthesis of pesticides, natural products and dyes, and has a broad application prospect. Powerful support is provided for multi-industry development, and the application prospect is wide. The polysubstituted pyrrole compound is synthesized through a one-pot method, and a new method is provided for preparing the novel polysubstituted pyrrole compound.

The invention provides a conjugated enyne compound, a preparation method and application thereof, a pharmaceutical composition and application thereof, and relates to the technical field of biological medicines. The conjugated enyne compound provided by the invention has the structural characteristics that the positions 5 and 6 and the positions 9 and 10 are acetylenic bonds, the C-12 position is substituted with acetylcysteine residues, the conjugated enyne compound is a derivative of endiyne biosynthesis precursor 1, 3, 5, 7, 9, 11, 13-pentadecene, the biosynthesis route of endiyne relates to an actinomycete mercaptan (MSH) detoxification mechanism, and the conjugated enyne compound can be used for preparing an actinomycete thiol compound. It is revealed that an MSH-dependent enzymatic detoxification mechanism participates in biosynthesis of endiyne, plays an important role in antibiotic resistance and environmental adaptation of endiyne strains, and also brings brand new reference and thinking for analysis of biosynthesis pathways of endiyne. In addition, the conjugated enyne compound provided by the invention has good anti-tumor activity.

The invention provides a method for synthesizing a series of substituted 1, 3-enyne compounds by carrying out coupling reaction on 2-alkynyl allyl ether compounds and hydrazone compounds under the conditions of palladium catalysis and alkali promotion. The method has the characteristics of mild reaction conditions, good functional group tolerance, simple post-treatment, low pollution, high economic benefit and the like.

The application discloses a method for selectively preparing quinolin-2-ketone or 3,4-dihydroquinolin-2-ketone compounds by regulating a photocatalyst, and the method is characterized in that quinolin-2-ketone or 3,4-dihydroquinolin-2-ketone compounds are prepared by intramolecular cyclization of 1,7-alkenyl alkynes under a photocatalytic condition; the selectivity of the product is controlled by the photocatalyst; when a Cu(I) photocatalyst with strong reducing capacity is used, 3,4-dihydroquinolin-2-ketone compounds are obtained; when a Cu(I) photocatalyst with weak reducing capacity is used, quinolin-2-ketone compounds are obtained; the raw material is simple and easy to obtain, the reaction condition is mild, the substrate has good universality, and the method is suitable for industrial production.

The invention belongs to the technical field of complex enyne preparation, and particularly relates to a method for synthesizing complex enyne through selective alpha / beta C-H alkynylation of aryl olefin and application of the complex enyne, and the method comprises the following steps: under relatively mild conditions, adopting a transition metal salt catalyst, enabling the aryl olefin and an alkynylation reagent to be subjected to selective alpha / beta C-H alkynylation reaction, and obtaining the complex enyne through selective alpha / beta C-H alkynylation. Complex alkyne is prepared; wherein the molar ratio of the aryl olefin to the alkynylation reagent to the transition metal salt catalyst to the additive is 1 to (1.5 to 2.5) to (0.05 to 0.15) to (1.5 to 3.0); according to the method for synthesizing the complex alkyne through selective alpha / beta C-H alkynylation of the aryl olefin and the application of the complex alkyne, the synthesis efficiency is high, the E / Z selectivity is excellent, the method is environmentally friendly, the production environmental protection pressure is small, the substrate application range of the method is wide, and individual substrates can be used for preparing luminescent layer materials of photoelectric devices or preparing anti-counterfeit labels and the like.

The application relates to a method for synthesizing dihydropyrrolo[2,3-c]pyrazole analogs. Specifically, under the catalysis of a transition metal and a bidentate ligand, dihydropyrrolo[2,3-c]pyrazole analogs can be obtained in high selectivity by using the bidentate ligand synergy, taking pyrazolinone as raw material and reacting with 1,3-alkyne under the action of triethylenediamine. The application uses cheap and commercially available 1,3-alkyne and easily obtained pyrazolinone, and a series of heterocyclic compounds with potential medicinal value are obtained in high selectivity under simple and mild conditions.

The invention discloses a method for preparing propargyl ester through 1, 3-enyne 1, 2-carbon esterification reaction based on a polarity matching strategy and application, and the method comprises the following steps: in the presence of a copper catalyst, a ligand and tert-butyl peroxybenzoate and under the heating condition, reacting a compound in a formula (1) with a compound in a formula (2) in an organic solvent to generate the propargyl ester in a formula (3). The preparation method provided by the invention can be suitable for alkyl-substituted 1, 3-enyne, aryl-substituted 1, 3-enyne, silicon-substituted 1, 3-enyne, an electron-rich C-H substrate, an electron-deficient C-H substrate, a Si-H substrate and a Ge-H substrate, and has the advantages that the substrates are simple and easy to obtain, and the universality is wide. The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide application range of reaction substrates, easy amplification of reaction, mild reaction conditions and the like, and can realize industrial production and application.

The application belongs to the technical field of organic synthesis chemistry, and discloses a rhodium-catalyzed diversity-oriented synthesis method of asymmetric 1,3-diynes and conjugated enynes compounds. The asymmetric 1,3-diynes and conjugated enynes compounds have structures shown in the following formula (I) and formula (II) respectively. The two types of target compounds are prepared according to the following steps: alkynol (1 equivalent), silver trifluoromethanesulfonate (1.5 equivalents) and 5 mol% dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer ([Cp*RhCl2]2) are sequentially added into a dry Schlenk flask, DMF (N,N-dimethylformamide) is used as a solvent, and the reaction is stirred at room temperature in an argon atmosphere for 4 hours (the reaction process is monitored by TLC or LC-MS). After the reaction is completed, ethyl acetate (15 mL*3) is added for extraction three times, the organic phase is combined and washed with saturated brine (10 mL*2) twice. The organic phase is collected and dried with anhydrous sodium sulfate, filtered, and the filtrate is rotary dried and then separated and purified by silica gel column chromatography, so that the asymmetric 1,3-diynes and conjugated enynes compounds are finally obtained. The asymmetric 1,3-diynes and conjugated enynes compounds are synthesized by the diversity-oriented synthesis method, and the method has the characteristics of mild conditions and simple operation.

The application discloses a phosphine-containing oxypentacyclic compound and a preparation method thereof, relates to the technical field of organic synthesis, and discloses a high-efficiency radical hydrophosphonylation reaction of 1,6-alkenyl alkyne and a secondary phosphine oxide compound through visible light oxidation-reduction catalysis. Under simple operation and mild conditions without alkali, various pentacyclic compounds containing a secondary phosphine oxide group are obtained. The preparation method has good regioselectivity, is easy to expand, and the prepared phosphine-containing oxypentacyclic compound has a good inhibitory effect on mouse colon cancer cells MC38.

The invention provides a carbonyl substituted alkenyl furan compound and a preparation method thereof. The carbonyl-substituted alkenyl furan compound has a furan ring and a carbonyl substituent in structure, olefin can be derived and converted in multiple directions, and the carbonyl-substituted alkenyl furan compound has structural novelty. The preparation method comprises the following step: reacting an eneyne ketone compound with alkenyl azide under the catalysis of zinc to generate the carbonyl-substituted alkenyl furan compound. The synthesis method is simple and rapid in preparation process, mild in catalytic condition and free of assistance of strong acid and strong alkali. The catalyst zinc is a high-yield metal, is cheap and easily available, and has no heavy metal residue risk in reaction conversion. Therefore, the method is expected to be used for industrial production.

The invention provides a preparation method of a succinimide derivative containing sulfone and carbonyl units, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, alkali, 1, 6-enyne, amine, p-toluenesulfonyl iodide and formic acid into an organic solvent, reacting at 80 DEG C for 20-24 hours, and performing post-treatment to obtain the succinimide derivative containing sulfone and carbonyl units. The preparation method is easy to operate, and post-treatment is simple and convenient; the method has the advantages of cheap and easily available reaction starting raw materials, wide tolerance range of substrate functional groups, high reaction efficiency, one-step efficient and rapid synthesis of the succinimide derivative containing sulfone and carbonyl units, and strong practicality.

The invention discloses a method for synthesizing a marine natural product Soldelalactone A, which comprises the following steps of: adding Soldelalactone A into a reaction kettle; the method comprises the following steps: by taking 6-triisopropyl siloxyhexyl-1-alkyne (2) as a raw material, firstly, carrying out asymmetric ethynylation reaction to obtain (S, E)-4-hydroxy-10-triisopropyl siloxydecan-2-ene-5-ethynoic acid ethyl ester (4); the preparation method comprises the following steps: preparing (R)-7-((1R, 2R)-2-formyl cyclopropyl)-heptyl-1, 7-lactone (11) by virtue of a multi-step reaction, such as DIBAL-H reduction, Simmons-Smith reaction, Yamagguchi esterification and the like, so as to obtain (R)-7-((1R, 2R)-2-formyl cyclopropyl)-heptyl-1, 7-lactone (11); the preparation method comprises the following steps: reacting Soldelalactone A with (S, 1E, 5Z)-1-iodoundecane-1, 5-diene-3-alcohol (12), and finally reacting with (S, 1E, 5Z)-1-iodoundecane-1, 5-diene-3-alcohol (12) to obtain According to the method, asymmetric ethynylation is applied to synthesis of Soldelalactone A for the first time, and the method has the advantages of being easy to operate, simple in route and the like.

The invention belongs to the technical field of heterocyclic compounds, and particularly relates to a fluorine-containing indole derivative and a preparation method thereof. The method comprises the following steps: adding a solvent and difluoroalkyl bromide into an eneyne derivative, a catalyst, a ligand and alkali, and stirring to obtain a mixture; under the illumination condition, stirring and reacting the mixture, adding coarse silica gel, removing the solvent, and separating to obtain the fluorine-containing indole derivative. Palladium free radical reaction and photocatalysis are combined, difluoroalkyl bromide serves as a reaction starting point, difluoroalkyl free radicals are initiated at the room temperature, the free radicals and eneyne derivatives are subjected to cross coupling / series cyclization reaction, two fluorine atoms are introduced, meanwhile, a polycyclic molecular skeleton is efficiently constructed, and the polycyclic molecular skeleton is synthesized. And the method has the remarkable advantages of high atom economy and mild reaction conditions, conforms to a green synthesis concept, and has a wide application prospect in industrial production.

The invention provides a preparation method of nitrogen-containing tricyclic quinolinone, and belongs to the technical field of heterocyclic compounds. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, alkali, 1, 7-enyne, perfluoroiodobutane and hydroxylamine into an organic solvent, reacting at 70-90 DEG C for 20-24 hours, and performing post-treatment to obtain the nitrogen-containing tricyclic quinolinone. The preparation method is simple and convenient to operate, the initial raw materials are cheap and easy to obtain, the reaction efficiency is high, the substrate compatibility is good, and nitrogen-containing tricyclic quinolinone can be efficiently and rapidly synthesized in one step.

The application discloses a preparation method of a tetrahydrobenzo[f]isoindole compound. The tetrahydrobenzo[f]isoindole compound is prepared by taking 1,6-alkynyl compound as raw material, taking alkaline substance as additive, and performing a cyclization reaction in an organic solvent. The structural formula of the 1,6-alkynyl compound is R is one of phenyl, p-fluorophenyl, p-chlorophenyl, p-bromophenyl, p-tert-butylphenyl, p-benzophenyl, p-methoxyphenyl, p-trifluoromethylphenyl, m-chlorophenyl, m-methoxyphenyl, m-cyanophenyl, m-formylphenyl, 3,5-dimethoxyphenyl, o-methoxyphenyl, o-methylphenyl, 1-naphthyl, 2-thienyl, 3-thienyl and p-methylphenyl. The preparation method of the tetrahydrobenzo[f]isoindole compound is characterized by using cheap and easily obtained alkaline substance as additive, using green and low-toxicity solvent, simple and mild reaction condition, high regioselectivity and the ability to be used for the development of heterocyclic drug molecules.

The application belongs to the technical field of photodegradable polymers, and discloses a light-responsive degradable polymer and a preparation method thereof. The method comprises the following steps: performing an ene-yne metathesis reaction on monomers containing a photodegradable group, or performing a reaction on monomers containing a photodegradable group and ene-yne monomers without a light-responsive fragment through block copolymerization or random copolymerization to obtain the light-responsive degradable polymer; and the monomers containing the photodegradable group are acyclic strain monomers. The application successfully obtains a light-responsive degradable polymer with a relatively high molecular weight and controllable polymerization effect through ene-yne cascade metathesis reaction, and the method has good effects.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing five-membered cyclobutene lactone through palladium catalysis of formic acid. The method comprises the following steps: adding 1, 4-enyne into a mixed solution composed of 1, 4-bis (diphenylphosphine) butane, palladium trifluoroacetate, formic acid, acetic anhydride and benzonitrile in an inert atmosphere, carrying out a reaction, and after the reaction is completed, carrying out purification treatment to obtain the five-membered cyclobutene lactone. According to the present invention, the design is reasonable, the olefins with different structures are adopted as the raw materials, the palladium trifluoroacetate is adopted as the catalyst, the 1, 4-bis (diphenylphosphine) butane is adopted as the ligand, the formic acid is adopted as the carbonyl source, and the acetic anhydride is adopted as the auxiliary agent so as to effectively achieve the 1, 4-eneyne series carbonylation reaction process; the method has the advantages of easily available raw materials, mild reaction conditions, simple operation and high yield of 76%; the method has positive effects on organic synthesis, natural product synthesis and the like.