18 results about "Carborane" patented technology

The invention belongs to the technical field of organic light-emitting materials, and particularly relates to a carborane derivative as well as a preparation method and application thereof. According to the invention, carborane with great application potential is combined with an imine structure which is widely applied to obtain a series of novel carborane imine compounds, so that the blank of carborane ketimine is filled, and the preparation method of the carborane imine compounds is obtained by research; nested carborane formed after boron removal of the compound has a good fluorescent effect and is expected to be used in the technical field of organic light-emitting materials.

The present disclosure provides a carborane-phospholipid conjugate which incorporates a carborane group at the end of one of the lipid arms of a phospholipid. The present disclosure also provides liposomal compositions comprising such carborane-phospholipid conjugates and their use for the delivery of at least one therapeutic agent and / or at least one diagnostic agent.

The invention discloses a carborane hybridized cobalt cluster-based metal organic framework capable of selectively adsorbing C2HF5 from a mixture containing C2HF5 and C2F6, a preparation method of the carborane hybridized cobalt cluster-based metal organic framework and application of the carborane hybridized cobalt cluster-based metal organic framework in the aspect of hexafluoroethane purification. The carborane hybridized cobalt cluster-based metal organic framework is composed of para-carborane dicarboxylate ions, metal ions Co < 2 + >, chloride ions and organic nitrogen-containing ligands N1, N1, N3, N3, N5, N5-hexa (pyridine-4-yl) benzene-1, 3, 5-triamine, two Co < 2 + > and four oxygen atoms of two para-carborane dicarboxylate ions are bridged with one mu-Cl to form a cobalt binuclear cluster, and the cobalt binuclear cluster is used for preparing the metal organic framework. The cobalt binuclear cluster is coordinated and connected with an organic nitrogen-containing ligand to form a three-dimensional framework with a double-cage structure.

The invention discloses a sulfonium sulfonate photoacid generator containing a carborane structure and application of the sulfonium sulfonate photoacid generator, and particularly provides a compound which is composed of anions and cations, the structure of the anions is shown as a formula (I) or a formula (II), and the structure of the cations is shown as a formula (I) or a formula (II). The photoacid generator provided by the invention is novel in structure, high in exposure energy and good in application prospect.

This invention discloses a near-infrared anthocyanin derivative based on boron cluster modification. The anthocyanin unit in the molecular structure of this derivative serves as a near-infrared fluorescence imaging and photothermal conversion unit, possessing not only near-infrared fluorescence imaging capabilities but also the ability to target tumor cells via an organic anion transport peptide-mediated pathway, enhancing selective accumulation in cancerous tissue. The nested carborane structure in the anthocyanin derivative molecular structure utilizes its strong electron-donating properties to induce photo-induced electron transfer with the anthocyanin unit, significantly improving photothermal conversion efficiency while reducing fluorescence quantum yield. The resulting molecule possesses tumor targeting, near-infrared imaging capabilities, and highly efficient photothermal and boron neutron capture therapy functions, achieving synergistic diagnostic and combined therapeutic effects of boron neutron capture therapy (BNCT) and photothermal therapy (PTT) in a single system.

The invention discloses a carborane fluorescent material as well as preparation and application thereof, and belongs to the technical field of photoelectric functional materials. The structural formula of the carborane fluorescent material is shown in the specification, and R comprises a fused ring aromatic group. The carborane fluorescent material provided by the invention has the characteristic of excitation dependence, the fluorescence emission spectrum of the carborane fluorescent material is remarkably changed along with the change of the wavelength of incident excitation light, and the carborane fluorescent material forms a distinct contrast with a traditional fluorescent material with a single emission wavelength; in addition, the carborane fluorescent material shows high fluorescence quantum yield, the technical defect that the fluorescence quantum yield of a traditional organic excitation dependent material is low is effectively overcome, and the fluorescence performance and the practical value are improved. Meanwhile, the material can be used for preparing carborane excitation dependent crystals and carborane excitation dependent fluorescent films with light activation characteristics, and the application range of the material in the field of photoelectric information is expanded.

The invention relates to the technical field of chiral self-assembly materials, and discloses a novel achiral fluorescent material which is characterized in that a D-A type conjugated skeleton is constructed by taking a spirofluorene unit as an electron donor (D) and carborane and triazine as electron acceptors (A); carborane has an AIE effect, triazine is an important six-membered heteroaromatic ring, has three nitrogen atoms, generates three regioisomers, and is widely used for preparing thermal delay fluorescent materials due to good thermal stability, light stability and thermal delay performance; a triazine derivative is used as a hub to be respectively connected with spirofluorene-o-carborane; a three-dimensional space structure of an o-carborane molecule and a rigid structure of a triazine molecule are combined, so that unique photoelectric properties are achieved; the invention provides a basis for the design of the boron cluster material in the aspects of photoelectric application and the like; and a new thought is provided for the research of the light-emitting boron cluster in circularly polarized light emission.

This invention discloses a porous framework material based on a carborane framework, its preparation method, and its applications. The porous framework material is obtained by coordinating a metal ion M with a carboxylated carborane to form a two-dimensional planar structure, and then using an organic nitrogen-containing ligand as a pillar to form a three-dimensional framework structure; the metal ion M is selected from Cu. 2+ Zn 2+ Ni 2+ Co 2+ At least one of the following: the carboxycarborane is selected from at least one of para-carboxycarborane and meta-carboxycarborane; the organic nitrogen-containing ligand is selected from at least one of 1,4-diazabicyclo[2.2.2]octane, pyrazine, 4,4'-bipyridine, and piperazine. Preparation method: The salt containing metal ion M, the carboxycarborane, and the organic nitrogen-containing ligand are reacted in a solvent at 50-100℃ to obtain a solid product; the solid product is placed in methanol for one or more solvent exchanges to remove solvent molecules, and then vacuum degassing and activation are performed to remove methanol molecules from the channels to obtain a porous framework material.

This invention relates to the field of synthetic chemistry, and discloses a carborane amino acid derivative, its preparation method, and its applications. The structural formula of the carborane amino acid derivative is shown below: ; where is C, is BH; o, m, and p are each independently selected from C, R, and C, respectively. 3 Or BH; and when o is selected from CR 3 When m and p are selected from BH; when m is selected from CR 3 When o and p are selected from BH; when p is selected from CR 3 At that time, o and m were selected from BH; R 1 R 2 and R 3 Each of the following groups is independently derived from one or more of H, OH, SH, NH2, halogen, trimethylsilyl, substituted or unsubstituted alkyl groups of 1-15 carbon atoms, substituted or unsubstituted benzyl, substituted or unsubstituted aryl groups of 6-20 carbon atoms, boric acid, and borate ester groups. This invention provides an efficient and practical synthetic route to overcome the bottleneck in the preparation of carborane amino acid compounds, yielding novel boron carrier candidates with significantly superior performance compared to existing clinical drugs.

The invention relates to the technical field of crystal materials, in particular to a bimetallic fluorescent nanocluster based on a sulfydryl carborane ligand and a preparation method and application of the bimetallic fluorescent nanocluster. The preparation method comprises the following steps: mixing a solution containing a carborane derivative ligand with two noble metal precursors or one noble metal precursor and one transition metal precursor to obtain a first mixed solution; stirring the first mixed solution and tetraphenylphosphine bromide in a dark place to obtain a second mixed solution; and stirring the second mixed solution and a reducing agent in a dark place to obtain the bimetallic fluorescent nanocluster. By introducing a carborane derivative ligand into a protection system of a noble metal bimetallic cluster, the ligand has strong metal binding capacity and electronegativity regulation and control characteristics of a carborane cage structure, and can control reduction kinetics under a low-temperature condition, so that synchronous nucleation and assembly of two noble metals or noble metals and transition metals are realized; therefore, the bimetallic cluster with a uniform structure and a clear atomic ratio is obtained.

This invention relates to the application of an iron complex containing an ortho-carborane Schiff base ligand in the synthesis of 2,4,6-trisubstituted pyrimidine compounds, characterized in that the 2,4,6-trisubstituted pyrimidine compounds have the following general structural formula: ; wherein Ar1, Ar2, and Ar3 are independently selected from phenyl or substituted phenyl groups, and the substituents in the substituted phenyl groups are selected from C 1‑10 Saturated alkyl, C 1‑10 Unsaturated alkyl groups, halogens, methoxy groups, ethoxy groups, nitro groups, and hydroxyl groups are used. The synthesis method of the 2,4,6-trisubstituted pyrimidine compounds is as follows: an iron complex, a 1,3-dione, an aromatic aldehyde, and ammonium acetate are dissolved in an organic solvent and reacted. After separation and purification, the 2,4,6-trisubstituted pyrimidine compounds are obtained. Compared with the prior art, the iron complex obtained by this invention can catalyze the reaction of a 1,3-dione, an aromatic aldehyde, and ammonium acetate at room temperature to synthesize triarylpyrimidine derivatives, exhibiting high reaction efficiency and being environmentally friendly.

Methods for modulating immune responses in a subject using carboranes and carborane analogs are disclosed. The carboranes and carborane analogs can selectively inhibit T cell activation and / or proliferation, reducing circulating T cell levels in a subject without significantly affecting circulating levels of neutrophils, monocytes, or B cells. As a result, the carboranes and carborane analogs can be used for therapeutic and / or prophylactic purposes, including treating or preventing chronic heart failure (CHF) in a subject following a myocardial infarction (MI), and treating or preventing graft-versus-host disease (GVHD), multiple sclerosis (MS), and / or experimental autoimmune encephalomyelitis (EAE) in a subject.

The invention discloses a synthesis method of a boron vertex perdeuterated carborane compound, and belongs to the field of organic chemistry. Polyhedral borane is used as a raw material, B-H activation is catalyzed by Pd (II), and cheap and easily available D2O is used as a deuterium source to synthesize boron vertex perdeuterated carborane. The method does not need additional additives, can be smoothly carried out in an inert gas atmosphere at 50-80 DEG C, has the advantages of simplicity in operation, high yield, wide substrate application range, easiness in large-scale production and the like, and can be used for rapidly and efficiently synthesizing the boron vertex perdeuterated carborane and the derivative of the boron vertex perdeuterated carborane.

This invention discloses a method for synthesizing and applying a nested carborane B-N coupling derivative with optical properties. The specific synthesis process is as follows: under anhydrous and oxygen-free conditions, nonborane (CH3)3N·B9H is synthesized... 13 Nested carboranes were prepared by reflux reaction of alkynes in toluene, followed by further reaction of the intermediate with alkali metal hydroxide (MOH) and purification. The nested carboranes were then subjected to a Brønsted-N coupling reaction with 8-aminoisoquinoline, and the crude product was purified to obtain the target product, the nested carborane Brønsted-N coupling derivative. This invention features a simple, safe, and high-yield synthetic process, avoiding the use of expensive ortho-carboranes as raw materials, thus significantly reducing the synthesis cost of nested carboranes. The synthesized nested carborane derivatives exhibit a significant positive solvation colorimetric effect, providing a new synthetic strategy for the design of boron cluster-based functional molecules and the development of luminescent materials.

To provide a boron nanocarrier that enables treatment of a primary tumor by boron neutron capture therapy and also enables treatment of a metastatic lesion through immunostimulation.SOLUTION: There is provided a boron cluster which is capable of encapsulating a water-soluble protein and to which boron neutron capture therapy (BNCT) is applicable, wherein ortho-, meta-, or para-carborane derivatives represented by formulae (I-I) to (I-III) form a spherical, rod-like, or plate-like aggregate. In the formulae, a small black dot represents BH, and R1 and R2 each independently represent a hydrogen atom, a linear, branched, or cyclic saturated or unsaturated alkyl group, a phenyl group, a benzyl group, a naphthyl group, an anthracenyl group, a phenanthryl group, or the like, and may be the same as or different from each other.SELECTED DRAWING: None

This invention relates to a silver complex containing a bisphosphine ortho-carborane ligand, its preparation method, and its applications. The structural formula of the silver complex is shown below: [Structure formula would be inserted here], where R is one of [variable name], [variable name], [variable name], or [variable name], and "•" represents a boron-hydrogen bond. The silver complex is used to catalyze the reaction of 1-bromophenylacetylene with aromatic carboxylic acids to synthesize (Z)-β-bromo-1-arylvinyl aryl esters. Compared with existing technologies, this invention has advantages such as a simple and green preparation method, high yield of the silver complex obtained in a one-pot reaction, high yield, simple product separation, insensitivity to air and water, and stable properties.

Acyclic boryl anions, such as bis(1-methyl-ortho-carboranyl)boryl anions, disclosed herein feature two bonding pairs and one lone pair of electrons on a boron center. The boryl anions include a counter cation of a Group I metal and are reactive as nucleophiles. The boryl anions can be generated in situ and used as reagents.

This invention discloses a carborane derivative, its preparation method, and its applications. Specifically, it involves the reaction of carborane with indole or pyrrole derivatives to prepare carborane-indole / pyrrole quinoxaline compounds. This invention combines a carborane derivative with a 3D structure with a nitrogen-containing heterocyclic quinoxaline with a special 2D electronic structure to obtain compounds with a 3D+2D structure. The synthesis method is simple, mild, and efficient. These compounds avoid aggregation-induced fluorescence quenching caused by 2D structure π-π stacking in the aggregated state, exhibiting good aggregation-induced emission effect. They also have good optical effects, displaying full-color light under 365nm ultraviolet light, and have applications in organic light-emitting materials.