25 results about "Structural isomer" patented technology

The objective is to provide a plant activator for soybeans that can increase soybean yield. [Solution] A plant activator for soybeans comprising at least one compound selected from ketooctadecadienoic acid or its derivatives, structural isomers, or salts thereof.

The invention discloses a bimetallic-Salen photocatalyst based on an isomerism effect as well as a preparation method and application of the bimetallic-Salen photocatalyst. The catalyst is synthesized through a solvothermal method, a diamine compound (such as 3, 3 '-diaminobenzidine or 1, 2-diaminobenzene) and a polyaldehyde compound (such as 2, 6-diformyl phenol or 3, 3', 5, 5 '-tetraformyl-4, 4'-biphenol) are used as organic ligands, a plurality of metal acetates (including Sc, In, Zn, Cu and the like) are used as metal sources, and the catalyst is synthesized through a solvothermal method. And the bimetallic-Salen isomer with a one-dimensional chain structure is prepared under a mild condition. The obtained material can form two isomers with zigzag (Z type) and linear (L type) structures according to different coordination orientations. The concept of'coordination oriented isomerization 'provided by the invention realizes accurate regulation and control of photoelectric properties on the molecular level, and provides a new theory and technical route for designing a multi-metal synergistic efficient artificial photosynthesis system. The catalyst material provided by the invention has wide application prospects in the fields of photocatalytic oxygen production, green oxidation reaction, sustainable energy conversion and the like.

Aspects of the invention include a nanoadditive comprising a synthetic melanin-inspired nanoparticle, wherein: the synthetic melanin-inspired nanoparticle comprises a plurality of covalently-linked artificial melanin precursors, and each artificial melanin precursor independently comprises an artificial allomelanin precursor, an artificial eumelanin precursor, or a structural isomer thereof. Aspects of the invention include methods of generating polymer nanocomposites and methods of enhancing a mechanical property of a polymeric material.

A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components (A) and (B) in a synergistically effective amount, wherein component (A) is a compound of formula Icompound of formula IwhereinR is hydrogen or methoxy;Q isR1 is hydrogen, halogen or C1-C6alkyl;R2 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, C3-C6alkinyl, C3-C6cycloalkyl-C3-C6alkinyl, halophenoxy, halophenyl-C3-C6alkinyl, C(C1-C4alkyl)=NO—C1-C4alkyl, C1-C6haloalkyl,C1-C6haloalkoxy, C2-C6haloalkenyl, or C2-C6haloalkenyloxy;R3 is hydrogen, halogen, C1-C6alkyl;R4, R5 and R6, independently from each other, are hydrogen, halogen or -≡-R7; with the proviso that at least one of R4, R5 and R6 is different from hydrogen;R7 is hydrogen, C1-C6alkyl, C1-C6haloalkyl or C1-C4alkoxyalkyl; andR8 is hydrogen or methoxy;and agrochemically acceptable salts / isomers / structural isomers / stereoisomers / diastereoisomers / enantiomers / tautomers and N-oxides of those compounds; and component (B) is a compound selected from compounds known for their fungicidal and / or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.

The invention provides a method for detecting N-(2-alanyl)-L-glutamine tetramer impurities in a compound amino acid liquid preparation by adopting a liquid chromatography-mass spectrometry technology, and the conditions of liquid chromatography are as follows: a chromatographic column taking amide bonded silica gel as a filler is adopted, a formic acid aqueous solution with the volume ratio concentration of 0.05%-0.3% is taken as a mobile phase A, a mobile phase B is taken as a mobile phase C, a mobile phase D is taken as a mobile phase C, a mobile phase D is taken as a mobile phase C, and a mobile phase D is taken as a mobile phase C; the method comprises the following steps: by taking a chromatographic column as a mobile phase A and a formic acid acetonitrile solution with the volume ratio concentration of 0.05-0.3% as a mobile phase B, eluting by adopting a gradient elution procedure, and the conditions of mass spectrometry are as follows: the ionization form is ESI < + >, and the detection mass-to-charge ratios are 418.1 / 218.1 and 418.1 / 147.1. The method can be used for effectively separating and detecting two alanyl-glutamine tetramer structure isomer impurities in the alanyl-glutamine liquid preparation.

The invention discloses a panchromatic organic room temperature phosphorescence (RTP) material system constructed based on a molecular isomerization strategy, and a preparation method and application thereof. The positions of nitrogen atoms in a tricyclic fused aromatic skeleton are accurately regulated and controlled to construct structural isomers including benzoindole [g], [e] and [f] and carbazole, and red, yellow, green and blue panchromatic RTP emission is realized. The compound can be efficiently synthesized by a one-pot solvent-free mechanochemical method, is doped in polymers such as PVA (Polyvinyl Alcohol) to construct a stable phosphorescent composite material, and shows a phosphorescent life as long as 4.23 seconds, an efficient TSFRET effect and adaptability to various matrixes. Theoretical and crystallographic analysis reveals a regulation and control mechanism of a heterogeneous structure on luminescence performance. The method is suitable for the fields of anti-counterfeiting, underwater imaging, security identification and the like, and a new path for constructing the panchromatic phosphorescent material is provided.

The invention provides a high-precision intelligent down feather separation method and system based on structural difference driving, and relates to the technical field of down feather separation. Dynamic humidification treatment is conducted on down feather raw materials, so that the water content of the surface layer of a material curtain is stabilized within a target range, then down feather in the material curtain is blown up through a high-speed air knife with a fixed angle, and the down feather separation efficiency is improved. The down feather flocculus moves upwards close to the upper wall and finally hovers in a channel above a wind field, a main wind flow in the center directly blows out feather stems, a hologram of a material curtain is shot through polarization laser, high-structure heterogeneous particles with the calculated confidence coefficient larger than a preset threshold value serve as candidate stem classes, a three-dimensional space coordinate point set of the candidate stem classes is output, and the high-structure heterogeneous particles with the confidence coefficient larger than the preset threshold value serve as the candidate stem classes. Quantitative high-voltage pulses are loaded according to the three-dimensional space coordinate point set, the candidate stems are made to deflect and taken away by airflow of the high-speed air knife, quality data of the down flowers are summarized into a report in real time to be transmitted back to a front-end control system, the atomized water amount, the air knife air pressure and the electrostatic voltage are fed back and adjusted, and closed-loop quality control from feeding to finished products is achieved.

The present application provides a method for preparing 5-hydroxy-1-methylpyrazole, which comprises the following steps: S1: subjecting N,N-dimethylamino alkyl acrylate and methylhydrazine to a Michael addition reaction in a two-phase solvent system consisting of water and a non-polar organic solvent in the presence of a phase transfer catalyst and a polymerization inhibitor to obtain a β-hydrazino ester intermediate; S2: subjecting the β-hydrazino ester intermediate to an internal cyclization reaction, and removing dimethylamine and low-carbon alcohol byproducts to obtain 5-hydroxy-1-methylpyrazole. This method can effectively improve the site selectivity of 5-hydroxy-1-methylpyrazole, significantly inhibit the formation of structural isomers, and particularly avoid the common 3-hydroxy-1-methylpyrazole byproduct in the prior art, thereby improving the purity and yield of the main product and having good reaction stability and scale-up adaptability.

Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein:wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

The present application relates to the technical field of dissolved organic matter, and particularly relates to a method for analyzing molecular structure information of dissolved organic matter based on high-resolution tandem mass spectrometry. The method for analyzing molecular structure information of dissolved organic matter based on high-resolution tandem mass spectrometry comprises the following steps: obtaining tandem mass spectrometry data; tracking fragmentation path and identifying functional groups, identifying possible functional group combinations based on neutral loss mass difference between starting point molecules and fragment ions, and tracking fragmentation path; identifying and quantifying isomers, identifying and quantifying isomers of target molecules based on fragmentation path; algorithm evaluation and parameter optimization; structure evolution and statistical analysis. The method for analyzing molecular structure information of dissolved organic matter based on high-resolution tandem mass spectrometry establishes an analysis process from parent ions to structural isomers by constructing fragmentation path, identifying neutral loss combinations and extracting isomer characteristics, and significantly improves the depth and accuracy of molecular structure analysis of dissolved organic matter.

The invention provides a method for preparing 5-hydroxy-1-methylpyrazole, which comprises the following steps: S1, carrying out Michael addition reaction on N, N-dimethylamino alkyl acrylate and methylhydrazine in a two-phase solvent system formed by water and a non-polar organic solvent in the presence of a phase transfer catalyst and a polymerization inhibitor to obtain 5-hydroxy-1-methylpyrazole; a beta-hydrazino ester intermediate is obtained; s2, the beta-hydrazino ester intermediate is subjected to an internal cyclization reaction, dimethylamine and low-carbon alcohol by-products are removed, and the 5-hydroxy-1-methylpyrazole is obtained. According to the method, the site selectivity of the 5-hydroxy-1-methylpyrazole can be effectively improved, generation of structural isomers is remarkably inhibited, particularly, common 3-hydroxy-1-methylpyrazole by-products in the prior art are avoided, the purity and yield of main products are improved, and the method has good reaction stability and amplification adaptability.

To provide a method for analyzing a wax or rubber composition that allows components such as structural isomers to be easily visualized, and to provide a rubber composition excellent in ozone resistance.SOLUTION: The method for analyzing a wax or rubber composition is a method using chromatography for analyzing a wax or rubber composition, the method being characterized in that an RI-plot method is used for analysis of the chromatography.SELECTED DRAWING: None

Methods for partial or full-surface sealing of drivable concrete traffic surfaces comprising the following work steps: 1. Substrate treatment with a primer based on aliphatic polyisocyanates and polyaspartic acid ester mixtures 2. Application of a liquid sealing layer based on aliphatic polyisocyanates and polyaspartic acid ester mixtures 3. Application of an adhesive layer based on aliphatic polyisocyanates and polyaspartic acid ester mixtures 4. Sprinkle quartz sand into the bonding layer 5. Application of at least one mastic asphalt wearing course characterized in that polyaspartic acid ester mixtures are used, containing at least i) a polyaspartic acid ester of the structure ii) at least one further amino-functional polyaspartic acid ester of the general structural formula in which R1 and R2 independently represent a methyl group or an ethyl group and X represents a divalent organic residue formed by removing the amino groups from an amino polyether of the general structural formula, which also includes corresponding constitutional isomers and n represents a number from 2 to 8, preferably 2.5 to 6.5 and particularly preferably 2.5 to 4.5.

A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components (A) and (B) in a synergistically effective amount, wherein component (A) is a compound of formula Icompound of formula IwhereinR is hydrogen or methoxy;Q isR1 is hydrogen, halogen or C1-C6alkyl;R2 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, C3-C6alkinyl, C3-C6cycloalkyl-C3-C6alkinyl, halophenoxy, halophenyl-C3-C6alkinyl, C(C1-C4alkyl)=NO-C1-C4alkyl, C1-C6haloalkyl,C1-C6haloalkoxy, C2-C6haloalkenyl, or C2-C6haloalkenyloxy;R3 is hydrogen, halogen, C1-C6alkyl;R4, R5 and R6, independently from each other, are hydrogen, halogen or -≡-R7; with the proviso that at least one of R4, R5 and R6 is different from hydrogen;R7 is hydrogen, C1-C6alkyl, C1-C6haloalkyl or C1-C4alkoxyalkyl; andR8 is hydrogen or methoxy;and agrochemically acceptable salts / isomers / structuralisomers / stereoisomers / diastereoisomers / enantiomers / tautomers and N-oxides of those compounds; and component (B) is a compound selected from compounds known for their fungicidal and / or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.

The application discloses a kind of negative electrode slurry for lithium ion battery and its preparation method, the preparation method of the negative electrode slurry includes the following steps: 1) with 3,4'-ODA or 3,4'-ASD and alpha-ODPA as raw material preparation solid component content≤5wt% with amino-terminated polyamic acid prepolymer solution;2) the polyamic acid prepolymer obtained is mixed with negative electrode active material and conductive agent uniformly, add or not add polar solvent, mix evenly to obtain slurry precursor;3) in slurry precursor, add asymmetric structure isomerization dianhydride end-capping agent, stir polymerization reaction, namely obtained;The asymmetric structure isomerization dianhydride end-capping agent is preferably MPDA, 3,3'-ODPA or alpha-ODPA, and the molar ratio of the total amount of all dianhydride in the entire preparation process to diamine is 1:1.The negative electrode slurry can effectively inhibit the expansion effect of negative electrode material, thereby improving the initial efficiency and cycle stability of the battery.

The invention relates to the technical field of soluble organic matters, in particular to a soluble organic matter molecular structure information analysis method based on high-resolution tandem mass spectrometry. The dissolved organic matter molecular structure information analysis method based on high-resolution tandem mass spectrometry comprises the following steps: acquiring tandem mass spectrometry data; fragmentation path tracking and functional group identification: identifying possible functional group combinations based on neutral mass loss difference between starting point molecules and fragment ions, and tracking fragmentation paths of the functional groups; isomer identification and quantification: identifying and quantifying the isomer of the target molecule based on the fragmentation path; evaluating an algorithm and optimizing parameters; and carrying out structural evolution and statistical analysis. According to the dissolved organic matter molecular structure information analysis method based on the high-resolution tandem mass spectrometry, the disintegration path is systematically constructed, the neutral loss combination is recognized, the isomer characteristics are extracted, the analysis process from parent ions to structural isomers is established, and the dissolved organic matter molecular structure analysis depth and precision are remarkably improved.

The invention relates to a preparation method of bis (mercaptomethyl)-3, 6, 9-trithia-n-undecane-1, 11-dimercaptan and a raw material composition of a modified polyurethane optical material containing the bis (mercaptomethyl)-3, 6, 9-trithia-n-undecane-1, 11-dimercaptan. The preparation method comprises three steps of nucleophilic substitution, chain extension reaction and thioetherification and chain extension, the prepared compound comprises two structural isomers of 5, 7-bis (mercaptomethyl)-3, 6, 9-trithia-n-undecane-1, 11-dimercapto alcohol (I) and 4, 8-bis (mercaptomethyl)-3, 6, 9-trithia-n-undecane-1, 11-dimercapto alcohol (II), the two structural isomers serve as a core monomer of a modified polyurethane optical material, and the two structural isomers of the modified polyurethane optical material can be used for preparing the modified polyurethane optical material. A modified polyurethane optical material can be prepared from a raw material composition composed of the monomer, polyisocyanate and a flexible hydroxyl bisphenol A glycidyl ether epoxy compound (formula A), and the optical material has the advantages of high light transmittance, high refractive index, excellent mechanical properties and the like. (I) (II) (A)

The invention discloses a cellobiose epimerase mutant with improved lactulose synthesis capability. The mutant CsCE-Q371E of the cellobiose epimerase (CsCE) is taken as a research object, the mutant CsCE-Q371E is constructed through random mutation, the mutant with the structural isomerization catalytic activity remarkably improved is obtained, and the structural isomerization catalytic activity is improved by about 263% compared with the structural isomerization catalytic activity of the CsCE-Q371E. The half-life period (t1 / 2) of the CsCE-IV reaches 478 min and is increased by about 10 times compared with the half-life period (t1 / 2) of CsCE-Q371E (42.68 min). The invention provides a feasible scheme for improvement of cellobiose epimerase, and has important significance for promoting enzymatic industrial synthesis of lactulose.

The invention discloses a mutant CE-FA with improved structural isomerization catalytic activity, and belongs to the field of enzyme engineering. According to the invention, a mutant CsCE-Q371E of cellobiose epimerase (CsCE) derived from Caldicellosipurtor schcharlyticus is taken as a research object, and a mutant CsCE-FA of which the structural isomeric activity is improved by 3.37 times compared with that of the CsCE-Q371E is obtained; under a buffer system with the temperature of 80 DEG C, the pH value of 7.5 and 50 mM of HEPEs, the half-life period (t1 / 2) of CsCE-FA reaches 545 min and is increased by about 10 times and about 8.37 h compared with the half-life period (t1 / 2) (42.68 min) of CsCE-Q371E, a feasible scheme is provided for CE enzyme improvement, and the CsCE-FA has important significance in promoting enzymatic industrial synthesis of lactulose.

The present disclosure addresses the problem of providing a novel compound or a novel agrochemical. Provided is a pyrazole compound represented by general formula (1) (where: A represents iodine, optionally substituted alkynyl, or the like; Z represents an optionally substituted divalent carbocyclic ring or the like; X represents an oxygen atom or carbonyl (C=O); T represents an oxygen atom or a sulfur atom; L represents optionally substituted alkyl or the like; R1 represents a hydrogen atom or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom or the like). Also provided is a structural isomer of the pyrazole compound, or a salt of the pyrazole compound or of the structural isomer.

To achieve an increase in the relative yield of a specific structural isomer in a liquid crystal compound having structural isomers.SOLUTION: The method for producing reaction mixture composition includes a step of reacting a compound represented by Formula (1) with a compound represented by Formula (2) using an organic solvent having a dielectric constant of 30 or more in the presence of a basic compound, thereby obtaining a reaction mixture composition containing a compound represented by Formula (3) and a compound represented by Formula (4), wherein, in area percentage values measured by liquid chromatography for the compounds represented by Formula (3) and Formula (4) in the reaction mixture composition, a value of Formula (3) / (Formula (3)+Formula (4)) is 0.75 or more and less than 0.95, or a value of Formula (4) / (Formula (3)+Formula (4)) is 0.75 or more and less than 0.95. A-Ar-A (1), HO-Ar-OH (2), A-Ar-OH (3), HO-Ar-A (4)SELECTED DRAWING: None

The application discloses a method for detecting triglyceride double bond structural isomers. The method comprises the following steps: based on the molecular ion peak [M+N]+, the fragment ion [M+N-R]+ and the fragment ion [M+N-2R]+ in the primary mass spectrum result and the secondary mass spectrum result of a triglyceride sample, comparing with a lipid compound database, so as to obtain the structure type of each branched chain of the triglyceride sample and determine the mass-to-charge ratio range of the fragment ion [M+N-R]+; based on the abundance of the acyl chain fragment ion between the molecular ion peak [M+N]+ and the fragment ion [M+N-R]+, the ratio of the abundance and the difference from the adjacent mass-to-charge ratio of the characteristic acyl chain fragment ion, so as to determine the position and cis-trans structure of each branched chain double bond. The method discloses the fine fragmentation rule of TAG double bond isomers, and constructs a comprehensive TAG double bond isomer characterization strategy.

The invention relates to a method for producing a reaction mixture composition, a mixture composition, and a method for producing a mixture composition. The present invention addresses the problem of relatively improving the yield of a specific structural isomer for a liquid crystal compound in which a structural isomer is present. The solution of the present invention is a method for producing a reaction mixture composition comprising a step for obtaining a reaction mixture composition containing a compound represented by formula (3) and a compound represented by formula (4) by reacting a compound represented by formula (1) and a compound represented by formula (2) in the presence of a basic compound using an organic solvent having a dielectric constant of 30 or more, in the reaction mixture composition, the value of formula (3) / (formula (3) + formula (4)) is 0.75 or more and less than 0.95, or the value of formula (4) / (formula (3) + formula (4)) is 0.75 or more and less than 0.95, among the area percentage values measured by liquid chromatography of the compound represented by formula (3) and the compound represented by formula (4) in the reaction mixture composition. A-Ar-A (1) HO-Ar-OH (2) A-Ar-OH (3) HO-Ar-A (4)

This invention provides a method for producing novel antigen-binding molecules that have the activity to regulate interactions between antigen molecules. [Solution] A method for producing an antibody preparation, comprising the steps of contacting an antibody solution with a reducing agent and, following the contact step, re-oxidizing the antibody, wherein the antibody comprises a first antigen-binding domain and a second antigen-binding domain linked to each other by at least one disulfide bond, the at least one disulfide bond being formed between amino acid residues at EU numbering position 191 in the CH1 region of each of the first and second antigen-binding domains, and the antibody solution comprises two structural isoforms of antibodies differing only by the at least one disulfide bond.