77 results about "Trans configuration" patented technology

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

A novel process for the selective elimination of fatty acid compounds containing carbon-carbon double bonds in trans configuration from a substrate containing cis- and trans-isomers of said fatty acid compounds, by selective adsorption by a microporous zeolite material is disclosed. The pore size and shape of usable zeolite materials enable differentiation between cis- and trans-isomers of unsaturated fatty acid chains. The zeolite materials used have a selectivity ratio alphatrans / cis higher than 1.00; this ratio is defined based on the elution properties of cis and trans double bond containing fatty acid methylesters dissolved in n-hexane during a column chromatography experiment with the zeolite material as the stationary phase and n-hexane as the mobile phase. Besides selective adsorption of trans-unsaturated fatty acid compounds, simultaneous or subsequent total or partial hydrogenation of the double bonds in said compounds can be carried out while using the same or similar zeolite material, containing finely dispersed catalytic active metals. The majority of these catalytic active sites must be inside the pores.

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula Iwherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

Processes for the production of polymers by emulsion polymerization of olefinically unsaturated monomers, in which olefinically unsaturated esters corresponding to formula (I):HOOC—CH═CH—COO—(BO)z(PO)y(EO)xR1  (I)in which R1 is an alkyl group or alkenylphenol group containing 8 to 24 carbon atoms, BO is a butylene oxide unit, PO is a propylene oxide unit and EO is an ethylene oxide unit and the indices x, y and z independently of one another stand for 0 or for numbers of 1 to 50, with the proviso that at least one of the indices x, y and z is not 0, the carboxyl group of the compounds (I) being completely or partly present in neutralized form and the C═C double bond being cis- or trans-configured; are used as copolymerizable emulsifiers.

A thin film transistor comprises a layer of organic semiconductor that comprises an N,N′-1,4,5,8-naphthalenetetracarboxylic acid diimide having at least one cycloalkyl group having a fluorinated substituent at its 4-position that adopts an equatorial orientation in the trans configuration of the cycloalkyl group and an axial orientation in the cis configuration of the cycloalkyl group. Such transistors can be a field effect transistor having a dielectric layer, a gate electrode, a source electrode and a drain electrode. The gate electrode and the thin film of organic semiconductor material both contact the dielectric layer, and the source electrode and the drain electrode both contact the thin film of organic semiconductor material.

The invention discloses a method for synthesizing (trans)-4-alkyl-3-alkene biphenyl derivative monomer liquid crystals, and belongs to the field of the preparation of monomer liquid crystal materials. The method comprises the following steps of: performing condensation of para-bromo cinnamaldehyde or 3-(4-bromo-phenyl)-propionaldehyde serving as a raw material and alcohol to prepare acetal, and performing a cross-coupling reaction of the acetal and 4-alkylbenzene borate in solvent under the catalytic action of palladium to obtain a biphenyl intermediate; and removing protective group alcohol of the biphenyl intermediate to produce an intermediate, performing a witting reaction of the intermediate and alkyltriphenylphosphonium halide in the presence of potassium tert-butoxide to produce a (cis, trans)-4-alkyl-3-alkene biphenyl derivative, and performing the inversion of cis and trans configuration to obtain the (trans)-4-alkyl-3-alkene biphenyl derivative monomer liquid crystals. The method has the advantages of low cost, high quality of products and mild reaction condition, and the expanded production is easy to perform. Therefore, the method is particularly suitable for the industrial production of the (trans)-4-alkyl-3-alkene biphenyl derivative monomer liquid crystals.

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula Iwherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

A thin film transistor comprises a layer of organic semiconductor that comprises an N,N′-1,4,5,8-naphthalenetetracarboxylic acid diimide having at least one cycloalkyl group having a fluorinated substituent at its 4-position that adopts an equatorial orientation in the trans configuration of the cycloalkyl group and an axial orientation in the cis configuration of the cycloalkyl group. Such transistors can be a field effect transistor having a dielectric layer, a gate electrode, a source electrode and a drain electrode. The gate electrode and the thin film of organic semiconductor material both contact the dielectric layer, and the source electrode and the drain electrode both contact the thin film of organic semiconductor material.

Methods and compositions for stimulating the growth of hair are disclosed wherein emulsions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula Iwherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal.

A hair growth applicator system and method includes a squeezable container, an application device, and a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula:wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification.

The invention discloses a method for preparing a diphenyl ethylene compound through a decarboxylic reaction. The method comprises the following steps of: performing a microwave radiation reaction on a 2,3-diaryl acrylic acid compound in polyethylene glycol by taking cuprous iodide and phenanthroline as catalysts; and purifying to obtain a diphenyl ethylenes compound. A substrate used in the method has the advantages of wide application range, predictability of the cis-trans configurations of raw materials, simple process, environment friendliness, low cost and high yield.

The present invention relates to a method for preparing a trans-1,4-disubstituted cyclohexane compound with at least one benzene-derived residue at 1- or 4- position. The method comprises an isomerization step for converting one or a plurality of cis-configured cyclohexane ring to trans configuration in the presence of additional compound which forms carbocations while a strong acid is used.

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

Cyclobutane-1,2-dicarboxylic esters of the formula: in which R1 is a C1-8-alkyl group, an optionally substituted mono- or bicyclic cycloaliphatic group having 3 to 10 ring carbon atoms, an optionally substituted aryl or arylalkyl group or an optionally substituted saturated heterocyclic group and R2 is either C1-4-alkyl or both radicals R2 together form a group of the formula -(CH2)n-(n is 2 to 4), are prepared from the corresponding maleic or fumaric esters and ketene acetals in the presence of a Lewis acid and a sterically hindered base. The reaction is stereoselective when optically active maleic or fumaric esters are employed. The cyclobutane-1,2-dicarboxylic esters (I), in particular those having trans configuration, are intermediates in the synthesis of pharmaceutically active compounds.

Gold(III) complexes having mixed ligands as anticancer agents. The atom is coordinated by bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and an ethylenediamine ligand. These complexes can exist in both cis- and trans-configurations. Also described are pharmaceutical compositions incorporating the gold(III) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis.

The present invention relates to compounds of the formula I in which substituents R<2> and R<3> are arranged in trans-configuration, Formula (I), wherein: R<1> is H or C1-C6 alkyl; C3-C7 cycloalkyl; R<2> is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6 -alkyl, halogen, nitro, cyano, SH, SR<4>, trihalo-C1-C6-alkyl, C1-C6 -alkoxy and phenyl, wherein R<4> is C1-C6 alkyl;R<3> is phenyl substituted with OR<5> wherein R<5> has the Formula (II), (III) or (IV) , wherein Y is chosen from NHR<4>, NR<4>2, NHCOR<4>, NHSO2R<4>, CONHR<4>, CONR<4>, CONR<4>2, COOH, COOR<4>, SO2R<4>, SOR<4>, SONHR<4>, SONR<4>2, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR<4>, trihalo-C1-C6- alkyl, C1-C6-alkyl and C1-C6 -alkoxy, preferably NHR<4>, NR2<4>, or a nitrogen heterocycle, wherein R<4> is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and / or treating estrogen-related disease conditions in a subject using compounds of formula (I), or its salts, optionally along with pharmaceutically acceptable excipients.

The invention discloses a detection method of EGFR cis mutation. Based on a Blocker PCR technology, different to-be-detected mutation sites are separately selected on a sense strand and antisense strand of a wild-type EGFR gene to design a corresponding Blocker, and the Blocker can be separately combined with the to-be-detected mutation sites of the sense strand and antisense strand of the wild-type EGFR gene to form a stable hybrid to prevent an upstream primer and a downstream primer from amplifying the wild-type EGFR gene which is subjected to monotonous mutation or trans-mutation. The method is simple and convenient, EGFR cis-configuration mutation can be effectively distinguished from trans-configuration mutation, the sensitivity is high, even 0.1% mutation in a peripheral blood sample can still be detected, and the detection method has a very high application value in clinical diagnosis of drug-resistant mutation of TKI.

Gold(III) complexes with mixed ligands as anticancer agents. The gold(III) cations are coordinated to bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and a 1,3-propylenediamine ligand. The diaminocyclohexane ligand can exist in both cis- and trans-configurations, resulting in isomeric gold(III) complexes. Also described are pharmaceutical compositions incorporating the gold(III) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis.

A synthetic method of the all trans long chain terpene primary alcohol is provided, which belongs to the technology field of the organic synthesis. The invention uses the cheap and easily gained geraniol, 2-allylic alcohol or the long chain terpene primary alcohol synthesized by the method as initial materials and uses the ethylenic chlorination reaction happened between the terpene primary alcohol acetate and the lime chlorite to form double bonds and the coupling reaction between the benzene sulphinate ester and the allyl chloride under alkali condition as the key steps, and gain the products through the hydrolysis reaction of the benzene removal sulphinate group and ester of the coupling product. The invention fully utilizes the complete framework of the primary alcohol and adds one or a plurality of isopentene units via coupling and synthesizes series of long chain terpene primary alcohol, which fully embodies the synthesis conception of the atomic economy; only a novel double bonds is formed in the reaction and other double bonds are the all trans double bonds in the raw materials, thereby ensures the trans configuration of the double bonds in the generated long chain terpene primary alcohol to the greatest extent. The invention has moderate reaction condition, simple synthetic route, simple operation, good reaction selectivity, high productive rate, easy separation and purification of the products and small environmental pollution.

The invention relates to a method of statistically analyzing protein peptide bond cis and trans structures, and belongs to the fields of protein structure analysis, structure prediction and cis and trans configuration isomerism research. The method is mainly characterized in that protein peptide planar carbon, nitrogen and oxygen atoms are used for setting up a coordinate frame, the longitude and latitude angles, in the unit sphere, of the atoms to be inspected are calculated, and all the atoms to be inspected are projected to the unit sphere to obtain a three-dimensional statistic distribution diagram of the atoms to be inspected. The visual protein structure analysis method can effectively express difference in peptide bond cis and trans structures and disclose the distribution characteristics of the atoms in the peptide bond cis and trans structures. The method is more novel than the existing method based on the structural chemistry, is capable of analyzing the structural characteristics of any side chain atoms and visually expressing geometric structure characteristics of certain atom or certain kinds of atoms in protein and is of important significance in protein structure predicting, structure optimizing, structure constraining and cis and trans configuration isomerism analyzing.

Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation / inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

The invention belongs to the technical field of rubber tires, and particularly relates to a preparing method for reducing the porosity of tire tread rubber. The preparing method comprises the following steps that 1, polyisoprene rubber containing trans-azobenzene groups in side chains, carbon black, zinc oxide, stearic acid, an accelerant, an anti-aging agent, sulphur and a scorch retarder are mixed in an internal mixer to obtain a rubber compound; 2, the rubber compound is extruded through an extruder, and the tire tread is produced; 3, the tire tread is placed below an ultraviolet lamp and irradiated. By the adoption of the preparing method for reducing the rubber porosity of the tire tread, the rubber mixing technology does not need to be changed, and steps are easy to implement; cis-trans configuration transformation occurs by utilizing the trans-azobenzene groups on the side chains of polyisoprene rubber under irradiation of the ultraviolet lamp, so that molecular chains are movedand arrayed more compactly, and thus the porosity of the tire tread rubber is reduced; by reducing the porosity, mechanical properties such as tensile strength, elongation at break, tear strength andabrasion resistance of a rubber material are improved, and thus the service life of the tire tread rubber is effectively prolonged.

A compound for an organic thin film transistor having a structure shown by the following formula (1):X1-L-Ar-L-X2   (1)wherein L is —C≡C—, or —CH═CH— in a trans configuration, X1 and X2 are independently an alkyl group having 2 to 30 carbon atoms or a haloalkyl group having 1 to 30 carbon atoms, and Ar is a substituted or unsubstituted aromatic hydrocarbon group having 14 to 60 ring carbon atoms which is a condensed ring of three or more rings, or a substituted or unsubstituted aromatic heterocyclic group having 11 to 60 ring atoms which is a condensed ring of three or more rings.

The invention discloses a new method of synthesizing polyhydrostilbene compound (E)-4-hydroxy-3, 5-dimethoxy stilbene, which is characterized in that: Lewis acid is used as catalyst; metallic zinc powder is used for promoting the reaction for the 4-hydroxy-3, 5-dimethoxy benzaldehyde and benzyl bromide for one pot reaction at ambient temperature, thereby realizing one-step synthesis upon 4-hydroxy-3, 5-dimethoxy stilbene with short synthesis line, high efficiency and high reaction yield (reaching more than 70%). The new method of synthesizing polyhydrostilbene compound (E)-4-hydroxy-3, 5-dimethoxy stilbene has the advantages that: the carbonyl of the 4-hydroxy-3, 5-dimethoxy benzaldehyde is directly converted to relative carbon-carbon double bond and all are trans configuration, thereby showing good stereo selectivity; functional group at the substrate can be reserved and can be completely guided into addition products without needing protection and de-protection of the functional group, thereby showing good chemical selectivity; the synthesizing method does not need any solvent but use cheap and nontoxic metallic zinc powder, thereby avoiding pollution of organic solvent on environment and being friendly upon environment.

A molecular manipulator includes a light-sensitive molecule, including a double bond, which changes a cis-trans configuration of the double bond in response to illumination by light of a selected wavelength, and a probe, for example, a probe of a scanned-proximity probe microscope, to which the light-sensitive molecule is attached. A method of making the molecular manipulator includes covalently bonding the light-sensitive molecule to the probe. A method of moving a nanostructure includes controllably grasping, moving, and releasing the nanostructure with the molecular manipulator.

The use in preparation of a medicament for treating and preventing the side effects of anti-cancer chemotherapy of a polyunsaturated fatty acid with a carbon chain length of 14 to 26 and with 2 to 6 double bonds in the molecule in cis or trans configuration, and a method of such treatment or prevention wherein said fatty acid is used as an active.

The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 alkyl; C3-C7 cycloalkyl; R2 is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6-alkyl, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkoxy and phenyl, wherein R4 is C1-C6 alkyl; R3 is phenyl substituted with OR5 wherein R5 has the formula (II), (III) or (IV) wherein Y is chosen from NHR4, NR42, NHCOR4, NHSO2R4, CONHR4, CONR4, CONR42, COOH, COOR4, SO2R4, SOR4, SONHR4, SONR42, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR4, NR24, or a nitrogen heterocycle, wherein R4 is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and / or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.