704 results about "One pot reaction" patented technology

Applicant has discovered an in situ method of preparing quaternary ammonium methocarbonate salts and quaternary ammonium alkylcarbonate salts in high yield from tertiary amines, methanol, and at least one of a cyclic carbonate, an aliphatic polyester (such as a polycarbonate), or an ester (such as a carbonate ester), and their subsequent conversion to quaternary ammonium bicarbonates, quaternary ammonium carbonates or both in a one-pot reaction. According to one embodiment of the invention, the method includes reacting an amine and methanol with at least one of a cyclic carbonate and an aliphatic polyester to yield a quaternary ammonium methocarbonate. This method does not produce or require the handling of corrosive quaternary ammonium hydroxides. Another embodiment is a method of preparing quaternary ammonium alkylcarbonate salts by reacting tertiary amines, methanol, and an ester. The quaternary ammonium methocarbonate or alkylcarbonate can be converted to the corresponding bicarbonate, carbonate, or mixture thereof by methods known in the art.

Process for preparing polymer-reinforced silica aerogels which comprises a one-pot reaction of at least one alkoxy silane in the presence of effective amounts of a polymer precursor to obtain a silica reaction product, the reaction product is gelled and subsequently subjected to conditions that promotes polymerization of the precursor and then supercritically dried to obtain the polymer-reinforced monolithic silica aerogels.

The present invention relates to a process of reducing sulfur- or nitrogen-containing compounds and also producing oxygenates, which can be used as an excellent octane booster in the reformulated gasoline and as a cetane booster for the future oxygenated diesel in a one-pot reaction.

The invention discloses an enzyme-chemocatalysis racemization removing preparation method for L-glufosinate-ammonium. According to the method, a one-pot reaction manner is adopted, under the molecular oxygen, immobilization D-amino acid oxidase catalyzes D-enantiomer in an enantioselectivity mode into 2-imino-4-(hydroxy methyl phosphonyl) butyric acid in a dehydrogenation mode, and palladium-ammonium formate catalyzes 2-imino -4-(hydroxy methyl phosphonyl) butyric acid into DL-glufosinate-ammonium in an in-situ reduction mode. Hydrogen peroxide produced in the process is efficiently decomposed into water and oxygen through catalase. Complete reacemization removing of DL-glufosinate-ammonium and efficient preparing of L-glufosinate-ammonium are achieved through biological oxidation-chemical reduction circulation. The method has the advantages that the process is simple, cost is low, environmental friendliness is achieved, and energy is saved. High-concentration DL-glufosinate-ammonium can be converted into L-glufosinate-ammonium. The yield is 90%, the optical purity of the product is 99%, and the method is suitable for industrial production of L-glufosinate-ammonium.

The invention discloses a method for preparing a cellulose ester grafted aliphatic polyester copolymer. The method comprises the following steps: 1) preparing a cellulose / ionic liquid solution by using cellulose as a raw material; 2) conducting a homogeneous acylation reaction of cellulose in the cellulose / ionic liquid solution to obtain partially substituted cellulose ester; and 3) further grafting aliphatic polyester to the partially substituted cellulose ester to obtain cellulose ester grafted aliphatic polyester copolymer. Compared with the existing method, the method has obvious advantages that cellulose with wide source is directly used as raw material to prepare the cellulose ester grafted aliphatic polyester copolymer by a one-pot reaction, without separation and purification of intermediate cellulose ester, and that the entire production process is greatly simplified, and has simple production process and easy operation. The cellulose ester grafted aliphatic polyester copolymer product produced by the method provided by the invention can be used for spinning, film making and molding parts, and also can be used as a compatibilizer for coating, paint, polymer and composite material.

The invention discloses a preparation method of 1T-phase molybdenum disulfide. The preparation method comprises the step of performing a hydrothermal reaction on an aqueous solution comprising a molybdenum source, a sulfur source and an ammonia source at 160-220 DEG C to prepare the 1T-phase molybdenum disulfide. The ammonia source is organic quaternary ammonium salt and/or inorganic ammonia salt. According to the preparation method disclosed by the invention, under the synergistic effect of the ammonia source and the hydrothermal reaction temperature, the 1T-phase molybdenum disulfide can be prepared through a one-pot reaction. The preparation method is simple, high in production efficiency and safe in preparation process.

This invention provides one-pot reaction for digesting polycarbonate waste with alkylene glycol in the presence of a basic catalyst at 180° C. under normal atmospheric pressure. The digested product mixture was found to consist of bisphenol A (BPA) and monoalkoxylated and bisalkoxylated diols of BPA. Alkoxylation of BPA and monoalkoxylated diols of BPA is performed by adding urea or urea derivative (or carbonic acid ester or amine ester) to the digested product mixture at a high temperature under normal atmospheric pressure to obtain the final product, i.e., bisalkoxylated diols of BPA in high yield. The bisalkoxylated diols of BPA may be used as raw materials to synthesize polymer such as polyurethane (PU) or polyester.

A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7, 10 and attaching a side chain at C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and intermediates used therein.

The invention discloses a method for synthesizing a flame retardant hexaphenoxy cyclotriphosphazene. The method is characterized by comprising the following steps of: performing a one-pot reaction on hexachlorocyclotriphosphazene, phenol, alkali metal hydroxides and other raw materials in a solvent system consisting of aromatic hydrocarbon or aryl halide and water by adopting noncyclic polyether as a catalyst at the temperature of between 20 and 30 DEG C for 3 to 5 hours; heating to the temperature of between 80 and 100 DEG C, reacting for 3 to 5 hours; reclaiming hydrated aromatic hydrocarbon or aryl halide through cooling, separation, washing and depressed pressure distillation after the reaction is completed; and cooling and coagulating the residues to obtain a white crystal solid powder product, wherein the yield is over 95 percent. The method has the characteristics of short reaction time, low cost, good quality and the like, is simple and safe in operation, and is environmentally-friendly and suitable for industrial production and application.

The invention relates to a preparation method for ionic liquid, especially to a one-step method for synthesis of a quaternary ammonium or quaternary phosphonium compound. According to the method, a nitrogen compound or phosphorus-containing compound, a proton compound and carbonic ester are added into a reactor together for a one-step reaction so as to synthesize corresponding quaternary ammonium or quaternary phosphonium ionic liquid, wherein the reaction is a one-pot reaction involving three reactants. The invention also provides a lithium ion secondary battery of the ionic liquid prepared by using the preparation method. The preparation method for the ionic liquid can broaden the selection scope of preparation raw materials for the ionic liquid, so the varieties of synthesized ionic liquid are enriched; and the preparation method utilizes nontoxic and harmless raw materials, has mild reaction conditions, low requirements on production equipment and low production cost, and meets demands of green industry and large-scale industrial production.

The invention relates to a simple and quick method for synthesizing an improved vitamin B1 intermediate 2-methyl-4-amino-5-aminomethylpyrimidine. The method comprises the following steps: condensing 3-alkyl (aryl) formamido-propionitrile serving as a raw material with acetamidine in the catalytic action of lewis acid; cyclizing with trimethyl orthoformate, and hydrolyzing under an alkaline condition to prepare the vitamin B1 key intermediate 2-methyl-4-amino-5-aminomethylpyrimidine. The four reacting processes are performed in sequence by a one-pot reaction, and the product in each step does not need to be separated and purified. According to the method, highly carcinogenic o-chloroaniline or other small molecular aniline compounds are not used, residues of o-chloroaniline compounds in the vitamin B1 product can be eliminated. Furthermore, the preparation process is short and convenient in flow, small in wastewater amount and high in yield.

The invention discloses a method for synthesizing an important intermediate 4-amino-3-(4-phenoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine of Ibrutinib. The method comprises the following steps: step one, condensing malononitrile and triethyl orthoformate and then carrying out a one-pot reaction with hydrazine hydrate to obtain 5-amino-4-cyano-pyrazole; step two, condensing the 5-amino-4-cyano-pyrazole with formamide to prepare a compound of formula (II) 4-amino-1H-pyrazolo[3,4-d]pyrimidine; step three, carrying out a bromination reaction of the compound of formula (II) and brominating agent to obtain a compound of formula (III) 4-amino-3-bromine-1H-pyrazolo[3,4-d]pyrimidine; step four, carrying out a Stille reaction on the compound of formula (III) and trimethyl p-phenoxy phenyltin under the catalyst effect of metal palladium to prepare a compound of formula (I) 4-amino-3-(4-phenoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine. According to the method for synthesizing the important intermediate 4-amino-3-(4-phenoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine of Ibrutinib provided by the invention, raw materials are low in price and easily obtained, the reaction conditions are moderate, the operation is simple and convenient, the method is suitable for industrial production, and a new way is provided for preparing Ibrutinib and intermediate.

The invention relates to a preparation method and an application of a hydrophobic starch sulfate ester in a cement water-reducing agent, and belongs to the fields of chemistry and chemical engineering. The preparation method comprises the following steps: adding a sulfamic acid, starch, urea, aliphatic tertiary alcohol or aryl methyl alcohol and water into a reactor under the conditions that the molar ratio of the sulfamic acid to the starch is (0.5-3.0):1, the molar ratio of the urea to the starch is (0.1-3.0):1, the molar ratio of the aliphatic tertiary alcohol or the aryl methyl alcohol to the starch is (0.1-1) and the adding amount of the water accounts for 10% to 30% of the dry weight of the starch; and reacting for 1 to 10 hours at a temperature of 80 DEG C to 150 DEG C, thereby obtaining the hydrophobic starch sulfate ester in which the sulfonyl substitution degree is between 0.04 and 0.89 as well as the alkyl substitution degree is between 0.01 and 0.2. The hydrophobic starch sulfate ester is applied to the cement water-reducing agent, wherein the mass percent of the hydrophobic starch sulfate ester accounts for 0.1% to 1.0% of that of cement. According to the method, a dry method and one-pot reaction are adopted, so that the environmental pollution caused by the application of an organic solvent is avoided. Thus, the production cost is decreased.

The invention relates to the field of covalent organic framework materials, and particularly provides a covalent organic framework material and a preparation method and application thereof. Accordingto the method, firstly, a COF material containing an imidazole structural unit is simply synthesized by adopting a three-component one-pot Povarov reaction, and then a structure of strong protonic acid polyion liquid is introduced into a porous framework by cooperating with a one-step post-synthesis modification strategy, so that the COF catalyst with high stability, high-density sulfonic acid group content and quinoline ring points is obtained and is used for efficiently catalyzing a Biginelli reaction. The invention provides a new way for the construction of the high-stability crystalline porous catalytic material.

A method for template-directed sequencing-by-synthesis of an array of target polynucleotide can include:

• • (a) providing an array of target polynucleotides in a fluidic vessel;
  • (b) contacting the array of polynucleotides with a solution comprising (i) polymerization complex and (ii) reversibly terminating and differently labeled A,C,G, and T/U nucleotides;
  • (c) incorporating one of the differently labeled nucleotides, using the polymerization complex, into a chain complementary to at least one of the array of polynucleotides;
  • (d) binding imaging tags to the differently labeled nucleotides of step (c);
  • (e) imaging and storing the identity and position of the imaging tags of step (d);
  • (f) reversing termination (b)-(e);
  • (g) repeating steps (b)-(e) and assembling a sequence for each of the array of target polynucleotides from the stored identity and position of the imaging tags, optionally as a homogeneous or one pot reaction. Additional methods of sequencing target polynucleotides are described herein.

The invention relates to new compounds of the formula, wherein R and R¹ are each independently hydrogen, a linear or branched C_1-40 alkyl, C_2-40 alkenyl or C_2-40 alkynyl group, an aryl or C_1-40 alkylaryl group or an optionally complex metal ion Mⁿ⁺/n wherein n is an integer from 1 to 8; the free valences of the silicate oxygen atoms are saturated by one or more of: silicon atoms of other groups of the formula, hydrogen, a linear or branched C_1-12 alkyl group or by cross-linking bridge members R³_qM¹(OR²)_mO_k/2 or Al(OR²)_3-pO_p/2 or R³Al(OR²)_2-rO_r/2; where M¹ is Si or Ti; R² is linear or branched C_1-12 alkyl group; and R³ is a linear or branched C_1-6 alkyl group; k is an integer from 1 to 4 and q and m are integers from 0 to 2; such that m+k+q=4; and p is an integer from 1 to 3; and r is an integer from 1 to 2; or other known oxo metal bridging systems; x, y and z are integers such that the radio of x:y+z, varies from 0.00001 to 100,000 with the fragments [O_3/2SiCH(CH₂PO(OR)(OR¹))CH₂CH₂SiO_3/2]_X and [O_3/2SiCH₂CH₂PO(OR)(OR¹)]_Y always present whilst the integer z varies from 0 to 200y. The compounds are useful as catalysts for a wide variety of reactions and have the advantages that they can be prepared in a one-pot reaction and have functional group losding can be tailored to be at a required level. In addition, the compounds have high chemical and thermal stability, fixed and rigid structures, are insoluble in organic solvents, high resistance to ageing, and can easily be purified and reused.

The invention discloses a method for catalytically preparing a spiral [cyclopropane-1,3'- indole] compound. According to the method, silicon amino rare earth compounds of [(Me3Si)2N]3Ln(mu-Cl)Li(THF)3 is used as a catalyst for catalytically replacing isatin, phosphite ester and olefin to prepare a product through one-pot reaction; in the catalyst, (Me3Si)2N represents trimethyl silicon amino; Ln represents positive trivalent rare earth metal irons and are one kind of metal irons selected from lanthanum, samarium, gadolinium, erbium or ytterbium; mu- represents a bridge key; THF represents tetrahydrofuran. In the method, the synthesis method of the catalyst is simple; the reaction raw materials are simple and can be easily obtained; the application range of a substrate is wide; the efficiency of the one-pot reaction method is high; the reaction conditions are mild; the yield of most target products can reach 85 percent or higher.

The invention discloses a 2-methacroyloxyethyl phosphorylcholine synthesizing method. The 2-methacroyloxyethyl phosphorylcholine synthesizing method comprises the following steps that ethanediol reacts with phosphorus oxychloride in the presence of catalysts to obtain 2-chlorine-2oxo-1, 3, 2-dioxaphospholane, and 2-methacroyloxyethyl phosphorylcholine is obtained by one-pot reaction of the 2-chlorine-2oxo-1, 3, 2-dioxaphospholane, hydroxyethyl methylacrylate and trimethylamine in a stress reaction flask. The 2-methacroyloxyethyl phosphorylcholine synthesizing method is simple in synthetic route, novel, simple and convenient in process, high in product yield and purity, and suitable for industrial production; the catalysts are low in price and easy to obtain; the environment is not affected.

A process for the preparation of a 5,5'-bi-1H-tetrazole diammonium salt by dropwisely adding the aqueous hydrogen peroxide to which a small amount of weakly acidic substance has been added, to a starting aqueous solution containing hydrogen cyanide or sodium cyanide or potassium cyanide, sodium azide and a catalytic amount of copper sulfate preferably at a low temperature to maintain the pH of the reaction solution over a range of from 5 to 6, heating the reaction solution to effect the oxidation and cyclization reaction, reacting the reaction product with ammonium chloride or an aqueous solution thereof, and recovering the formed ammonium salt in the form of sparingly soluble crystals. The desired product is obtained in a high yield and in a high purity from the starting materials which are cheaply available and are easy to handle through a decreased number of steps, i.e., through a one-pot reaction without requiring cumbersome after-treatment.