18 results about "One pot reaction" patented technology

The application discloses a kind of S-delta-substituted caprolactam chemical / enzyme series preparation method, and the specific preparation method is: 1-substituted high allyl amine occurs dynamic kinetic resolution reaction with acrylic ester compound under the catalysis of alkaline protease (special treatment) and generates S-acryl (1-substituted high allyl) amine, then the product occurs intramolecular olefin metathesis under the catalysis of Grubbs reagent and finally generates S-delta-substituted caprolactam shown in formula (1), wherein, substituent R is phenyl, halogenated phenyl or C2-C12 alkyl.The application has mild reaction condition, is conducive to reducing the equipment requirement of preparation process, improves synthesis safety and economy;Secondly, the reaction course of the method is simple, and single configuration S-delta-substituted caprolactam can be obtained by one-pot reaction, with very high atom economy.

The invention relates to the technical field of preparation of fluorine-containing intermediates, and discloses a synthesis method for preparing 4, 4 '-difluorobenzophenone through a one-pot domino reaction. The invention aims to solve the problems of expensive raw materials, complex process, serious pollution, low yield and purity and the like in the prior art. According to the method, 4-fluorobenzoic acid and fluorobenzene are taken as raw materials, any one or more of trifluoromethanesulfonic anhydride, phosphorus pentoxide, trifluoroacetic anhydride or paraformaldehyde is taken as an acid catalyst under a solvent-free condition, and a target product is directly prepared through a one-pot reaction. After the reaction is finished, excessive fluorobenzene is recovered, a high-purity product is obtained through extraction, alkali washing, drying and concentration, and unreacted 4-fluorobenzoic acid can be recovered by acidifying a water phase. The method has the advantages of simple process, easily available raw materials, mild conditions and environmental protection, realizes the excellent effects that the conversion rate of 4-fluorobenzoic acid is greater than 99%, the product yield is greater than 95% and the purity is greater than 99%, and is suitable for industrial production.

The invention belongs to the technical field of high polymer materials, and provides a slip ring grafted polyrotaxane multi-block topological copolymer as well as a preparation method and application thereof. The topological copolymer comprises a multi-block copolymerized main chain and a plurality of cyclic molecules grafted with polyester side chains, the cyclic molecules and the main chain form a mechanically interlocked polyrotaxane topological structure, and the cyclic molecules are limited by block steric hindrance outside the main chain and freely slide along blocks inside the main chain; and the main chain outer block and the slip ring grafted polyester side chain are incompatible chain segments with different polarity and / or crystallization thermodynamics. According to the preparation method, polyether, cyclodextrin or a derivative thereof and a polymeric monomer are used as raw materials, and the preparation method is completed through a one-pot reaction of assembling and step-by-step polymerization. The topological copolymer can respectively form physical interpenetration in two phases of a microphase separation system through an incompatible chain segment, and utilizes a slidable mechanical interlocking structure to buffer external force and dissipate energy, so that the bonding strength and stability of a phase interface are remarkably improved, and the topological copolymer can be used as a high-performance blending compatilizer and a strengthening and toughening additive.

The present invention relates to innovative process conditions for the preparation of formula (I) and in particular N-(diphenylmethylene)-2-(3-chloro-5-trifluoromethyl-2-pyridyl) glycinate via the contact of benzophenone glycine imine ethyl ester and substituted halogenated pyridines in the presence of novel solvent systems and bases. Furthermore, the present invention provides a one-pot reaction for the preparation of pyridyl benzamides using the preparation process of the compound of formula (I). (I)

The present disclosure provides enzymes and methods of using those enzymes to transfer sugar moieties to substrate steviol glycosides. Specifically, designed beta-1,2-glycosyltransferases and sucrose synthases are used in one-pot reactions to convert stevioside and Reb A to Reb E and Reb D. Additionally, designed beta-1,2-glycosyltransferases can be used in one-pot reactions with sucrose synthases and beta-1,3-glycosyltransferases to produce Reb M from stevioside and / or Reb A.

To provide a method for producing a compound suitable for use as a perfume and / or aroma having an aromatic note of musk.SOLUTION: A process for preparing a compound of formula (I) comprising the steps of: (A) etherifying a phenol derivative to obtain an allyl ether derivative; (B) Claisen rearrangement of the ether from step (A) followed by cyclisation; (C) acetylating or formylating the intermediate from step (B); wherein steps (A) and (B) are carried out in a one pot reaction. Wherein R1, R2, R3 and R4 represent hydrogen, methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, tert-butyl, iso-butyl, acetyl, formyl or SELECTED DRAWING: None

The application discloses a method for in-situ aqueous phase catalytic conversion of guaiacol and lignin into phenolic compounds, and belongs to the technical field of catalytic conversion for preparing phenolic compounds. The method adopts guaiacol or lignin to selectively generate phenol through HDO under the action of a Ni / MgO catalyst. In the absence of external hydrogen and under environmentally-friendly conditions, a one-pot reaction of the Ni / MgO catalyst can obtain a phenolic (phenol and methyl phenol) yield of up to 12.1 wt% from industrial lignin. The application opens up a non-noble metal catalytic strategy, realizes the conversion from renewable lignin resources to phenolic compounds in the absence of external hydrogen, and is consistent with the concept of green chemistry and sustainable development.

The invention relates to a process for preparing (hetero)aromatic compounds substituted with a hydroxyethylamino group (B) from aromatic compounds bearing an amino group (A) in the presence i) of (di)(alkyl)glycolaldehyde dimer and ii) in a reduction medium, it being understood that step i) and ii) are performed simultaneously or as a "one pot" reaction.

The application discloses a synthesis method of 2,2'-biphenyldicarboxylic acid compounds, which comprises the following steps: carrying out a reduction coupling reaction on a halogenated benzoic acid compound and a metal reducing agent under the action of an alkali and a nickel catalyst / bidentate ligand composite catalyst system to obtain the 2,2'-biphenyldicarboxylic acid compound. The method uses 2-halogenated benzoic acid compounds as raw materials, and can obtain the 2,2'-biphenyldicarboxylic acid compounds in a high yield through one-pot reaction catalyzed by a transition metal Ni. The method has the advantages of low cost, mild reaction condition, simple reaction operation, high ortho-regioselectivity, avoidance of unnecessary derivatization steps, fast and efficient coupling reaction and the like, and has high industrial production value.

The invention relates to a process for preparing (hetero)aromatic compounds substituted with a hydroxyethylamino group (B) from aromatic compounds bearing a nitro(so) group (A) in the presence i) of (di)(alkyl)glycolaldehyde dimer and ii) in a reduction medium, it being understood that step i) and ii) are performed simultaneously or as a "one pot" reaction.

Methods and systems, which use a reconstituted Type III-A CRISPR-Cas system, MORIARTY (Multipronged, One-pot, RNA Induced, Augmentable, Rapid, Test sYstem) for the detection of disease are provided herein. The methods and systems may be performed either without amplification or coupled to RNA transcription as one-pot reactions. The systems and methods herein may be highly sensitive and may be used to detect viruses, including SARS-CoV-2.

The invention provides a synthesis method of a polypeptide compound containing two pairs of disulfide bonds, and the two pairs of disulfide bonds are accurately constructed step by step in one pot by selecting different cysteine sulfydryl protecting groups and different deprotection and oxidation conditions. In the first step, hydrogen peroxide is adopted as an oxidizing agent to construct a first pair of disulfide bonds, efficient construction with pure water as a solvent is achieved, and the problem that in the prior art, hydrogen peroxide is adopted as an oxidizing agent to oxidize the disulfide bonds under the alkaline condition can be solved. The improvement of the step reaction not only reduces the addition of reagents, is more green and economic, but also reduces the introduction of impurities in the reaction, and is more beneficial to the proceeding of the second-step reaction of the one-pot method. A one-pot reaction strategy is adopted, the intermediate purification process is reduced, operation is simpler and more convenient, intermediate product loss caused by purification is reduced, and the total reaction yield is greatly increased. The method is relatively good in universality, is also applicable to different types of paired polypeptide compounds containing two pairs of disulfide bonds, and is relatively good in total yield.

The present disclosure relates to a polymer electrolyte having improved ionic conductivity and mechanical strength and a manufacturing method thereof, and in particular to an ionic gel having improved ionic conductivity and mechanical strength, a polymer electrolyte including the ionic gel, and a manufacturing method thereof. The manufacturing method of the ionic gel is capable of simply and effectively manufacturing a polymer matrix through a one-pot reaction, thus exhibiting a simple processing step, thereby exhibiting excellent processing efficiency and generating economic benefits. Furthermore, although the glass transition temperature (Tg) of a monomer included in the polymer matrix is low, the polymer electrolyte including the ionic gel can still exhibit excellent ionic conductivity and mechanical strength.

The application discloses a chemical synthesis method of 5-phenyl-5-aroyl-1,3-dioxane compound. The method is one-pot reaction of alkyne compound and paraformaldehyde under catalysis of boron trifluoride ether, to generate 5-phenyl-5-aroyl-1,3-dioxane compound. The method has the advantages of mild reaction condition, simple operation, easy-to-obtain raw material, excellent compatibility of substrate functional groups, high reaction yield, low reaction cost and the like, and has high application value.

The invention belongs to the field of chemical synthesis, and particularly relates to a dicarbazolyl substituted triaryl methanol compound and a synthesis method thereof. The compound is structurally characterized in that two identical carbazole ring skeletons, a benzene ring and a hydroxyl group are connected to the same quaternary carbon. The synthesis method comprises the following steps: sequentially adding carbazole or a derivative thereof, alpha-ketonic acid, a catalyst, trifluoroacetic acid and a solvent into a reactor, sealing and stirring the obtained mixture at a heating temperature until the reaction is finished, and carrying out post-treatment, separation and purification to obtain the dicarbazolyl substituted triaryl methanol compound. The method is a brand new synthesis method, quaternary carbon containing two large-steric-hindrance carbazole rings, a benzene ring and a hydroxyl group can be constructed through a one-pot reaction, and the reaction is very efficient. The synthesis method can be used for efficiently synthesizing a series of brand new dicarbazolyl substituted triaryl methanol compounds, and has important application prospects in the fields of medicines and functional materials.

The application discloses a preparation method of N-terminal alkenyl azaheteroarene, which comprises the following steps: carrying out one-pot reaction of aromatic aldehyde and azaheteroarene under the action of alkali in an atmospheric atmosphere and dimethyl sulfoxide solvent, and obtaining N-terminal alkenyl azaheteroarene compound. The alkenyl of the N-terminal alkenyl azaheteroarene compound obtained by the method is derived from the raw material aldehyde, but one double bond carbon atom is added compared with the original aldehyde raw material. In the reaction process, the carbon-oxygen double bond of the raw material aromatic aldehyde is converted into carbon-carbon double bond, and the hydrogen atom on the carbonyl carbon of the aromatic aldehyde is replaced by the nitrogen atom in the azaheteroarene molecule. The method has the advantages of wide and easy raw material source, green environmental protection, low price and simple operation, and is favorable for industrialized production.

The invention discloses a method for synthesizing benzotriazole-benzenesulfonamide derivatives by electro-catalysis isonitrile bifunctionalization, and belongs to the technical field of organic electrosynthesizing.The method comprises the steps that benzotriazole, isonitrile, sulfonamide, electrolyte and alkali are added into a three-necked bottle, a solvent is added for dissolution, a carbon rod is used as an anode, a platinum sheet is used as a cathode, and the mixture is subjected to electro-catalysis reaction for 2-4 hours; carrying out stirring reaction under the conditions of constant current and room temperature, and monitoring the reaction process by TLC (Thin Layer Chromatography); and after the reaction is completed, performing vacuum concentration, and purifying residues through column chromatography to obtain a target product. According to the method for synthesizing the benzotriazole-benzenesulfonamide derivative through electro-catalysis isonitrile bifunctionalization, under the mild electrochemical condition, benzotriazole, benzenesulfonamide and isonitrile serve as raw materials, and a series of benzotriazole-benzenesulfonamide derivatives are efficiently constructed through a three-component one-pot reaction; and the method has the remarkable characteristics of high atom economy, no need of an exogenous oxidant, excellent functional group compatibility and the like.

The present application mainly relates to the efficient synthesis of a kind of tri-substituted hydroxylamine compound by transition metal Pd catalytic C-O bond coupling.The present application realizes the one-pot reaction of tertiary chloroalkane or secondary chloroalkane and O-acyl hydroxylamine compound under the action of catalyst, ligand and base in argon atmosphere, realizes C-O bond coupling in the case of keeping the fragile N-O bond unbroken, and obtains a kind of big steric hindrance N,N,O-trialkyl substituted hydroxylamine derivative with high chemical selectivity.The present application has the characteristics of excellent chemical selectivity to construct C-O bond, simple experimental operation, wide source of raw materials, high yield, wide substrate application range and excellent functional group tolerance, and the synthesized product is suitable for being contained in drug small molecule screening library for the discovery of lead drug.