40 results about "One pot reaction" patented technology

The present disclosure provides enzymes and methods of using those enzymes to transfer sugar moieties to the substrate steviol glycosides. The designed beta-1, 3-glycosyltransferase can be used for adding a glucose monomer connected with beta-1, 3 to steviol glycosides. In particular, the designed beta-1, 3-glycosyltransferase is used in a one-pot reaction together with a beta-1, 2-glycosyltransferase and a sucrose synthase to convert stevioside and / or Reb A to Reb M.

The application discloses a kind of S-delta-substituted caprolactam chemical / enzyme series preparation method, and the specific preparation method is: 1-substituted high allyl amine occurs dynamic kinetic resolution reaction with acrylic ester compound under the catalysis of alkaline protease (special treatment) and generates S-acryl (1-substituted high allyl) amine, then the product occurs intramolecular olefin metathesis under the catalysis of Grubbs reagent and finally generates S-delta-substituted caprolactam shown in formula (1), wherein, substituent R is phenyl, halogenated phenyl or C2-C12 alkyl.The application has mild reaction condition, is conducive to reducing the equipment requirement of preparation process, improves synthesis safety and economy;Secondly, the reaction course of the method is simple, and single configuration S-delta-substituted caprolactam can be obtained by one-pot reaction, with very high atom economy.

Disclosed herein are synthetic methods for increasing the solubility of metallocenes, such as metallocenes containing perfluorobenzyl (indene) groups. These methods can include alkylating a perfluoroaromatic ring of a metallocene precursor using a lithium alkylate reagent in a one-pot reaction. In addition, these processes may be employed without changing reaction equipment or conditions, without separating new intermediates, and at the same time, generally retaining the desired catalyst characteristics.

The invention discloses a multi-component preparation method of an N-sulfonyl fluoride compound, and relates to the field of organic synthesis. The preparation method comprises the following steps: reacting an amine compound with a chlorine source in a solvent to generate an intermediate, then continuously adding a sulfur dioxide source and a fluorine source for reaction, and purifying after one-pot reaction to obtain the N-sulfonyl fluoride compound, the structural general formula of the amine compound is shown in the specification, the structural general formula of the N-sulfonyl fluoride compound is shown in the specification. The reaction general formula is shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation, mild conditions, safety, environmental protection, short reaction time, good yield and wide substrate range, can be applied to various types of amine substrates, including primary (alkyl / aromatic) amine, secondary (alkyl / aromatic) amine, amide, nitrogen-containing heteroaromatic ring and the like, and has wide application prospects. Wide application prospects are realized in the fields of medicinal chemistry, synthetic chemistry, material science and the like.

The invention relates to the technical field of preparation of fluorine-containing intermediates, and discloses a synthesis method for preparing 4, 4 '-difluorobenzophenone through a one-pot domino reaction. The invention aims to solve the problems of expensive raw materials, complex process, serious pollution, low yield and purity and the like in the prior art. According to the method, 4-fluorobenzoic acid and fluorobenzene are taken as raw materials, any one or more of trifluoromethanesulfonic anhydride, phosphorus pentoxide, trifluoroacetic anhydride or paraformaldehyde is taken as an acid catalyst under a solvent-free condition, and a target product is directly prepared through a one-pot reaction. After the reaction is finished, excessive fluorobenzene is recovered, a high-purity product is obtained through extraction, alkali washing, drying and concentration, and unreacted 4-fluorobenzoic acid can be recovered by acidifying a water phase. The method has the advantages of simple process, easily available raw materials, mild conditions and environmental protection, realizes the excellent effects that the conversion rate of 4-fluorobenzoic acid is greater than 99%, the product yield is greater than 95% and the purity is greater than 99%, and is suitable for industrial production.

The invention belongs to the technical field of high polymer materials, and provides a slip ring grafted polyrotaxane multi-block topological copolymer as well as a preparation method and application thereof. The topological copolymer comprises a multi-block copolymerized main chain and a plurality of cyclic molecules grafted with polyester side chains, the cyclic molecules and the main chain form a mechanically interlocked polyrotaxane topological structure, and the cyclic molecules are limited by block steric hindrance outside the main chain and freely slide along blocks inside the main chain; and the main chain outer block and the slip ring grafted polyester side chain are incompatible chain segments with different polarity and / or crystallization thermodynamics. According to the preparation method, polyether, cyclodextrin or a derivative thereof and a polymeric monomer are used as raw materials, and the preparation method is completed through a one-pot reaction of assembling and step-by-step polymerization. The topological copolymer can respectively form physical interpenetration in two phases of a microphase separation system through an incompatible chain segment, and utilizes a slidable mechanical interlocking structure to buffer external force and dissipate energy, so that the bonding strength and stability of a phase interface are remarkably improved, and the topological copolymer can be used as a high-performance blending compatilizer and a strengthening and toughening additive.

The present invention relates to innovative process conditions for the preparation of formula (I) and in particular N-(diphenylmethylene)-2-(3-chloro-5-trifluoromethyl-2-pyridyl) glycinate via the contact of benzophenone glycine imine ethyl ester and substituted halogenated pyridines in the presence of novel solvent systems and bases. Furthermore, the present invention provides a one-pot reaction for the preparation of pyridyl benzamides using the preparation process of the compound of formula (I). (I)

The invention belongs to the technical field of chemical synthesis, and discloses a synthesis method of a 3, 4-disubstituted aminopyridine compound. Under the action of a secondary amine catalyst, alpha-amino aldehyde and 3-substituted acrolein are connected in series to form cyclization and directly react with hydroxylamine hydrochloride under the catalytic condition of acid without separation, and the 3, 4-disubstituted aminopyridine compound is prepared through one-pot reaction. Therefore, the preparation method provided by the invention has the characteristics of simplicity in operation, no need of metal catalysis, environment friendliness, short reaction time and the like, and provides a thought for efficient and rapid synthesis of the compounds. The method can be potentially used for drug research and development and efficient synthesis of fine chemicals containing 3, 4-disubstituted aminopyridine structural units.

The present disclosure provides enzymes and methods of using those enzymes to transfer sugar moieties to substrate steviol glycosides. Specifically, designed beta-1,2-glycosyltransferases and sucrose synthases are used in one-pot reactions to convert stevioside and Reb A to Reb E and Reb D. Additionally, designed beta-1,2-glycosyltransferases can be used in one-pot reactions with sucrose synthases and beta-1,3-glycosyltransferases to produce Reb M from stevioside and / or Reb A.

To provide a method for producing a compound suitable for use as a perfume and / or aroma having an aromatic note of musk.SOLUTION: A process for preparing a compound of formula (I) comprising the steps of: (A) etherifying a phenol derivative to obtain an allyl ether derivative; (B) Claisen rearrangement of the ether from step (A) followed by cyclisation; (C) acetylating or formylating the intermediate from step (B); wherein steps (A) and (B) are carried out in a one pot reaction. Wherein R1, R2, R3 and R4 represent hydrogen, methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, tert-butyl, iso-butyl, acetyl, formyl or SELECTED DRAWING: None

The application discloses a method for in-situ aqueous phase catalytic conversion of guaiacol and lignin into phenolic compounds, and belongs to the technical field of catalytic conversion for preparing phenolic compounds. The method adopts guaiacol or lignin to selectively generate phenol through HDO under the action of a Ni / MgO catalyst. In the absence of external hydrogen and under environmentally-friendly conditions, a one-pot reaction of the Ni / MgO catalyst can obtain a phenolic (phenol and methyl phenol) yield of up to 12.1 wt% from industrial lignin. The application opens up a non-noble metal catalytic strategy, realizes the conversion from renewable lignin resources to phenolic compounds in the absence of external hydrogen, and is consistent with the concept of green chemistry and sustainable development.

The present invention discloses (Z)-β-iodo-β-methylthio olefins and their synthesis method. In the disclosed compounds, iodine and methylthio are located on the same carbon atom of the carbon-carbon double bond, and they are formed by the double substitution reaction of olefins with iodine and sulfoxide on the terminal carbon atom. The reaction does not require other catalysts or additives, and only through a one-pot reaction under heating conditions, (Z)-β-iodo-β-alkylthio styrene can be selectively obtained; this method has mild reaction conditions, simple operation, no need for external catalysts or additives, good selectivity and high yield, which is conducive to industrial production.

The invention discloses a method for synthesizing 1,2-disubstituted olefins by reacting terminal olefins with sulfoxides. The method comprises the following steps: the terminal olefins and sulfoxides are reacted in one pot in the presence of an iron salt and hydrogen peroxide to generate the 1,2-disubstituted olefins. In the method, the sulfoxide serves as both a hydrocarbylating agent and a solvent for the olefins. The reaction product is a 1,2-disubstituted olefin in which a terminal carbon atom in the terminal olefin is coupled to a sulfoxide hydrocarbyl group, thereby lengthening the olefin carbon chain. The method has mild reaction conditions, good selectivity, and high yield, and is conducive to industrial production.

The invention relates to a process for preparing (hetero)aromatic compounds substituted with a hydroxyethylamino group (B) from aromatic compounds bearing an amino group (A) in the presence i) of (di)(alkyl)glycolaldehyde dimer and ii) in a reduction medium, it being understood that step i) and ii) are performed simultaneously or as a "one pot" reaction.

The application discloses a synthesis method of 2,2'-biphenyldicarboxylic acid compounds, which comprises the following steps: carrying out a reduction coupling reaction on a halogenated benzoic acid compound and a metal reducing agent under the action of an alkali and a nickel catalyst / bidentate ligand composite catalyst system to obtain the 2,2'-biphenyldicarboxylic acid compound. The method uses 2-halogenated benzoic acid compounds as raw materials, and can obtain the 2,2'-biphenyldicarboxylic acid compounds in a high yield through one-pot reaction catalyzed by a transition metal Ni. The method has the advantages of low cost, mild reaction condition, simple reaction operation, high ortho-regioselectivity, avoidance of unnecessary derivatization steps, fast and efficient coupling reaction and the like, and has high industrial production value.

The invention relates to a process for preparing (hetero)aromatic compounds substituted with a hydroxyethylamino group (B) from aromatic compounds bearing a nitro(so) group (A) in the presence i) of (di)(alkyl)glycolaldehyde dimer and ii) in a reduction medium, it being understood that step i) and ii) are performed simultaneously or as a "one pot" reaction.

The invention belongs to the technical field of organic matter synthesis, and relates to a preparation method of 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide, and the 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide is synthesized by dissolving N-(2, 2, 2-trifluoroethyl)-2-haloacetamide, nitrite ester, hydrazine, alkali and a catalyst in an alcohol solvent and carrying out one-pot reaction in the presence of hydrogen. The invention provides a new method for preparing the 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide, provides a new scheme with good yield for the preparation of the 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide, and has important practical significance and practical value.

A method for preparing 1-cyano-2-acyl-1,2,3,4-tetrahydroisoquinoline compounds, which are shown by formula III. In the presence of light, a photosensitizer and a desiccant, the compound shown by the general formula of structure I first undergoes a photoredox reaction, and then the compound shown by the general formula of structure II is added in situ, and then a Reissert-type reaction is carried out to obtain the 1-cyano-2-acyl-1,2,3,4-tetrahydroisoquinoline compound shown by the general formula of structure III. The present invention uses simple and readily available 1,2,3,4-tetrahydroisoquinoline compounds and acyl nitriles as raw materials; the acyl nitrile serves as both an acyl source and a cyano source, on the one hand avoiding highly toxic cyano sources, and on the other hand having high atom economy; under blue light irradiation, air can be used as an oxidant, with high environmental friendliness; the 1-cyano-2-acyl-1,2,3,4-tetrahydroisoquinoline compound is constructed through a "one-pot" reaction cascade of photoredox and Reissert-type reactions, with mild reaction conditions, simple operation, high step economy, and good application prospects.

In one aspect, the disclosure relates to a one-pot nucleic acid detection platform that is designed to optimize nucleic acid diagnostics while ensuring quick and dependable results. The platform uniquely incorporates the thermostable Cas12b enzyme, enabling direct nucleic acid detection from untreated samples. The disclosure also relates to positively- and negatively-charged designed variants of Cas12a and their use for detection of nucleic acids. In one aspect, the pH and thermal conditions disclosed herein that allow the one pot reaction without extraction would work with any enzyme that is functional under these conditions.

The present invention discloses a method for constructing iodoalkenyl sulfide from olefins, iodine and dimethyl sulfoxide. This method uses olefins, iodine and sulfoxide as raw materials. Under heating conditions, iodine and sulfoxide simultaneously undergo substitution reactions on the same carbon atom of the olefin. Without adding other catalysts or additives, through a one-pot reaction, an α-iodoalkenyl sulfide product is selectively obtained. This method has mild reaction conditions, simple operation, does not require external catalysts or additives, has good selectivity and high yield, and is conducive to industrial production.

The invention provides a method for preparing formate through co-conversion of polyester plastic and CO2, which comprises the following steps: capturing CO2 by using an inorganic alkali aqueous solution to obtain a carbonate-containing aqueous solution; the inorganic alkali aqueous solution is selected from at least one of a sodium hydroxide aqueous solution and a potassium hydroxide aqueous solution; the method comprises the following steps: adding polyester plastic and a catalyst into a carbonate-containing aqueous solution at 200-350 DEG C, adding or not adding inorganic alkali, hydrolyzing and depolymerizing the polyester plastic to obtain a to-be-reacted monomer, and enabling the to-be-reacted monomer and water to be subjected to a reforming reaction by the catalyst in a reaction solution to obtain hydrogen and CO2; meanwhile, CO2 reacts with carbonate to generate bicarbonate; the temperature is reduced to 50-170 DEG C, the pressure is increased to 7.5-10 MPa, bicarbonate is subjected to a hydrogenation reaction under the catalytic action of a catalyst, and a formate solution is obtained; the catalyst is selected from at least one of palladium carbon, platinum carbon and ruthenium carbon, and the mass percentage of metal in the catalyst is 0.1-10%. The method is mild in reaction condition, and a single product formate can be obtained with high yield through one-pot reaction.

The present invention provides a catalyst for preparing dialkyl carbonates through the coupling reaction of a monohydric alcohol and CO2, a preparation method and application thereof, and a preparation method for symmetrical dialkyl carbonates, and relates to the technical field of organic synthesis. The catalyst of the present invention comprises an active component and a carrier; the active component is an oxide of an active metal; the active metal comprises cobalt, as well as gallium and / or indium; and the carrier comprises γ-Al2O3 or SiO2. The multiple components of the catalyst of the present invention interact with each other, which can effectively adjust the acidity and alkalinity of the catalyst. It is used for the "one-pot" reaction of a monohydric alcohol, carbon dioxide, and propargyl alcohol to prepare symmetrical dialkyl carbonates, and has high activity and high selectivity. The results of the examples show that the catalyst of the present invention has a conversion rate of 80 to 93% for monohydric alcohols and a selectivity for symmetrical dialkyl carbonates of 95 to 99%; the catalyst has good thermal stability and a long catalytic life, and its activity does not decrease significantly after continuous use for more than 360 hours.

The invention discloses a catalytic asymmetric synthesis method of a beta-substituted gamma-butyrolactone compound, which comprises the following steps: under the action of palladium acetate, a chiral ligand, an acidic additive, an oxidant and a pro-oxidant, reacting an allyl alcohol compound with an alkenyl ether compound in an organic solvent to obtain the beta-substituted gamma-butyrolactone compound, the invention also provides podophyllotoxin, a homologue thereof and a synthesis method of a chiral intermediate compound in a synthesis process of the podophyllotoxin. According to the method, one-pot reaction / oxidation reaction is adopted, so that catalytic asymmetric synthesis of the beta-substituted-gamma-butyrolactone compound is economically and efficiently realized; the reaction substrates are two chemical raw materials and are good in universality, reaction conditions are mild, the process is simple and safe, and operation is easy and convenient.

Methods and systems, which use a reconstituted Type III-A CRISPR-Cas system, MORIARTY (Multipronged, One-pot, RNA Induced, Augmentable, Rapid, Test sYstem) for the detection of disease are provided herein. The methods and systems may be performed either without amplification or coupled to RNA transcription as one-pot reactions. The systems and methods herein may be highly sensitive and may be used to detect viruses, including SARS-CoV-2.

The present application belongs to the technical field of fluorescent probe, and particularly relates to a new method for constructing a meso-aryl-substituted heptamethine cyanine dye. The present application uses cyanine ketone as a raw material, aryl lithium as a reaction reagent, and a meso-aryl-substituted heptamethine cyanine (ArCy7) dye is obtained through a one-pot reaction with a high yield. The ArCy7 dye prepared by the method of the present application effectively improves the water solubility, chemical / photo stability and anti-aggregation ability of the Cy7 dye, thereby promoting the application of the dye in constructing a fluorescent probe, protein labeling or tumor diagnosis and treatment.

The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl esterIn accordance with the present invention, a pharmaceutical grade Compound (I) can be efficiently prepared by a one-pot reactions preparation step that includes the esterification of the 15-OH bimatoprost by coupling bimatoprost phenyl-boronate with 6-(nitrooxy) hexanoic acid and the removal of the boronate ester protecting group, followed by an efficient purification step.The invention refers also to high purity Compound (I) substantially free of the impurity 15-(6-chlorohexanoyl) ester of bimatoprost and to ophthalmic pharmaceutical formulations containing the high purity compound.

The invention provides a synthesis method of a polypeptide compound containing two pairs of disulfide bonds, and the two pairs of disulfide bonds are accurately constructed step by step in one pot by selecting different cysteine sulfydryl protecting groups and different deprotection and oxidation conditions. In the first step, hydrogen peroxide is adopted as an oxidizing agent to construct a first pair of disulfide bonds, efficient construction with pure water as a solvent is achieved, and the problem that in the prior art, hydrogen peroxide is adopted as an oxidizing agent to oxidize the disulfide bonds under the alkaline condition can be solved. The improvement of the step reaction not only reduces the addition of reagents, is more green and economic, but also reduces the introduction of impurities in the reaction, and is more beneficial to the proceeding of the second-step reaction of the one-pot method. A one-pot reaction strategy is adopted, the intermediate purification process is reduced, operation is simpler and more convenient, intermediate product loss caused by purification is reduced, and the total reaction yield is greatly increased. The method is relatively good in universality, is also applicable to different types of paired polypeptide compounds containing two pairs of disulfide bonds, and is relatively good in total yield.

The present disclosure relates to a polymer electrolyte having improved ionic conductivity and mechanical strength and a manufacturing method thereof, and in particular to an ionic gel having improved ionic conductivity and mechanical strength, a polymer electrolyte including the ionic gel, and a manufacturing method thereof. The manufacturing method of the ionic gel is capable of simply and effectively manufacturing a polymer matrix through a one-pot reaction, thus exhibiting a simple processing step, thereby exhibiting excellent processing efficiency and generating economic benefits. Furthermore, although the glass transition temperature (Tg) of a monomer included in the polymer matrix is low, the polymer electrolyte including the ionic gel can still exhibit excellent ionic conductivity and mechanical strength.

The invention discloses a preparation method of high-purity N-methyl halogenated benzamide, which comprises the following steps: by taking halogenated benzoic acid as a raw material, in a high-pressure reaction kettle, only adding methanol and ammonia gas, and realizing amidation and N-methylation of the halogenated benzoic acid by utilizing a one-pot reaction to prepare the N-methyl halogenated benzamide, it can be purified by a basic hydrolysis reaction. According to the invention, methanol is successfully used as a methyl source to realize N-methylation of amide, the use of an acyl halide reagent in the traditional preparation process of N-methyl halogenated benzamide is avoided, the N-methyl halogenated benzamide product is directly prepared through a one-pot reaction under the condition of no additional catalyst, and the purity of the N-methyl halogenated benzamide product is enabled to be gt through simple purification; the method can be used for recycling byproducts and unreacted halogenated benzoic acid, and the byproduct and unreacted halogenated benzoic acid can be recycled. Compared with the traditional process, the method has the advantages that the raw materials are cheap and easy to obtain, the reaction system is green and environment-friendly, the operation steps are simple, and the method is a novel method for effectively producing the N-methyl halogenated benzamide.

The application discloses a chemical synthesis method of 5-phenyl-5-aroyl-1,3-dioxane compound. The method is one-pot reaction of alkyne compound and paraformaldehyde under catalysis of boron trifluoride ether, to generate 5-phenyl-5-aroyl-1,3-dioxane compound. The method has the advantages of mild reaction condition, simple operation, easy-to-obtain raw material, excellent compatibility of substrate functional groups, high reaction yield, low reaction cost and the like, and has high application value.