236results about "Phosphatide foodstuff compositions" patented technology

The invention provides a method for preparing high-purity phosphatidylserine by a batch enzyme catalysis method based on dynamic choline removal, and belongs to the technical field of enzymatic reaction. According to the method disclosed by the invention, in a reaction system for preparing phosphatidylserine, a byproduct choline is selectively adsorbed by adopting resin. Choline in a reaction system is removed in real time through the integrated adsorption separation module, the enzyme inhibition problem is solved, and meanwhile, the PC conversion rate is larger than or equal to 98% and the PS purity is larger than or equal to 96% in combination with the immobilized enzyme circulation technology; the enzyme can be reused for more than or equal to 20 times (activity retention is more than or equal to 90%); and the choline residual concentration is less than or equal to 0.5 mM (an inhibition threshold value or less).

The invention provides an antistatic agent for fuel oil and a preparation method thereof, and belongs to the technical field of petrochemical engineering, and the preparation method comprises the following steps: S1, adding soybean lecithin and chlorosulfonic acid into dichloroethane, uniformly mixing, under the protection of nitrogen, heating and stirring for reaction, neutralizing reaction liquid, and performing rotary evaporation to obtain sulfonated soybean lecithin; the preparation method comprises the following steps: adding sulfonated soybean lecithin and ethidene diamine into absolute ethyl alcohol, then adding p-toluenesulfonic acid, heating and stirring for reaction, and carrying out reduced pressure distillation to obtain modified soybean lecithin; s2, dispersing the SiO2 particles in absolute ethyl alcohol, adding KH-550, and performing ultrasonic treatment, centrifugation and drying to obtain pretreated SiO2 particles; and uniformly mixing the modified soybean lecithin and the pretreated SiO2 particles, adding the mixture into a supercritical fluid reactor, heating and pressurizing, ultrasonically dispersing, and drying to obtain the antistatic agent. The antistatic agent has the advantages of good dispersibility, strong stability and strong antistatic capability.

The invention discloses a preparation method of high-purity polyene phosphatidylcholine (PC) euphausia superba oil. Edible ethanol alcohol-soluble euphausia superba oil (the phospholipid content of the oil is 40-60%, the PC content of the phospholipid is about 80%, and the euphausia superba oil is a product obtained by carrying out preliminary impurity removal and fishy smell removal on a crude euphausia superba oil product obtained by carrying out crude extraction by using ethanol) is used as a raw material, an AO material (an adsorbent prepared by taking aluminum oxide as a main material and adding a small amount of silica gel) is used as an adsorbent, and absolute ethanol is used as a percolation eluting agent to prepare a phosphorus oil product of which the PC is greater than or equal to 97%. The method is characterized in that (1) alcohol-soluble krill oil in which most non-phospholipid impurities are removed is adopted as a raw material of an upper percolation column liquid, so that the purity of a subsequent product is ensured; (2) an AO material (mainly composed of alumina and added with a small amount of an adsorbent prepared from silica gel) is subjected to a high-temperature dehydration process, so that the separation capacity of a chromatographic agent is improved; and (3) single absolute ethyl alcohol is adopted as percolating liquid, so that the method is green and environment-friendly. And (4) the large-diameter percolation column is adopted, so that industrial-scale production can be realized. The method is simple in process, high in product purity and suitable for large-scale industrial preparation of the krill oil product of polyene phosphatidylcholine.

Disclosed are newly designed polymeric compounds (lipid-polymer conjugates) useful for forming lipid bilayers and liposomes comprising them, lipid bilayers and liposomes formed thereby, and uses thereof. Also disclosed is a method of preparing a new design of a polymeric compound (lipid-polymer conjugate).

The invention discloses an application of sea cucumber phospholipid in preparation of a preparation for improving sleep and / or treating sleep disorders. Researches find that the sea cucumber phospholipid can significantly prolong the sleep time of the zebrafish with sleep disorder induced by caffeine and improve abnormal changes of IL-6 and GABA levels in brains of the zebrafish. Meanwhile, the sea cucumber phospholipid can obviously prolong the sleep duration of the mice induced by pentobarbital sodium. After being prepared into a preparation, the sea cucumber phospholipid can be used for improving insomnia and treating sleep disorder related diseases, and has a wide application prospect in the field of sleep disorder.

The invention discloses simulated breast milk phospholipid added with enriched sphingomyelin and a preparation method and application thereof, and belongs to the technical field of phospholipid processing. In order to solve the technical problems that in the prior art, infant inflammation and anaphylaxis are caused by breast milk phospholipids, and fat utilization is insufficient, the simulated breast milk phospholipids added with enriched sphingomyelin are provided, a more accurate compounding proportion is obtained through a Python scoring method, and the simulated breast milk phospholipids more similar to healthy breast milk are obtained; the relative content of sphingomyelin in a yak ghee phospholipid enrichment product is improved through enrichment reaction, and the quality and nutritional value of simulated breast milk phospholipid are improved. The simulated breast milk phospholipid provided by the invention has relatively high milk fat globule membrane and phospholipid formation rate, and relatively high quality and safety; the composition can be used for preparing infant formula milk powder, reducing infant inflammation and anaphylaxis and improving the fat utilization rate.

A compound presented by the general formula (1), its racemic form, or their salt thereof (in general formula (1), X represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R1 represents R1a-Y-R1b (wherein R1a and R1b independently represent a saturated or unsaturated aliphatic hydrocarbon group, aromatic group, heterocyclic group, or a combination thereof, and Y represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom), R2 independently represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.).

The present invention belongs to the field of soybean by-product processing and discloses a method for preparing high-quality transparent soybean lecithin, comprising the following steps: (1) a dual solvent system 1: dissolving soybean lecithin in a non-polar solvent, then adding a certain amount of monohydric alcohol aqueous solution and stirring to obtain a mixed solution 1; (2) centrifuging the mixed solution 1 to remove impurities and collecting the upper non-polar solvent clear liquid; (3) a dual solvent system 2: adding a certain amount of polyol to the collected upper non-polar solvent clear liquid and stirring to obtain a mixed solution 2; (4) centrifuging the mixed solution 2 to remove impurities and water, collecting the upper non-polar solvent clear liquid, and recovering the non-polar solvent to obtain transparent soybean lecithin. The method disclosed in the present invention has the advantages of simple process, low equipment requirements, and solvent recyclability. The prepared soybean lecithin has extremely high transparency and good fluidity, and no substances such as proteins and polysaccharides that affect the transparency of the soybean lecithin are detected.

The invention belongs to the field of soybean by-product processing, and discloses a method for preparing high-purity soybean phospholipid, which comprises the following steps: completely dissolving soybean concentrated phospholipid with an extractant, continuously adding the extractant, stopping adding the extractant after 30-50 wt% of precipitates are separated out, separating to obtain the precipitates and a mixed solution, standing the mixed solution, collecting the clarified mixed solution and the bottom precipitates, combining the precipitates to obtain soybean phospholipid mixture A; recovering the extractant in the clarified mixed solution to obtain soybean phospholipid mixture B, adding an ethanol aqueous solution, stirring until it becomes paste-like, adding an alkane solvent, stopping stirring after mixture B is completely dissolved, recovering the alkane solvent, soybean phospholipid mixture B is divided into two layers, removing the upper layer to obtain soybean phospholipid mixture C, removing water, and mixing it with soybean phospholipid mixture A. The acetone-insoluble matter content in soybean phospholipid mixture A is >95%, and the acetone-insoluble matter content in soybean phospholipid mixture C is >90%.

The invention discloses a hydrogenated lecithin synthesis method based on a nickel catalysis continuous flow strategy, relates to the technical field of preparation of hydrogenated lecithin, and aims to solve the problem that the cost of preparing the hydrogenated lecithin is greatly increased due to the fact that the hydrogen pressure is relatively high and recycling of a catalyst is not considered in an existing method. The preparation method is technically characterized by comprising the following steps: (1) performing heat treatment on moso bamboo powder in a protective gas atmosphere to obtain a carbon carrier; dipping the carbon carrier in an alkali solution, and then carrying out a high-temperature activation reaction in a protective gas atmosphere; an activated carbon carrier is obtained; the preparation method comprises the following steps: loading a nickel source, an auxiliary agent and a structure stabilizer into an activated carbon carrier by dipping to obtain a catalyst precursor, and pyrolyzing the catalyst precursor in a protective gas atmosphere to obtain a Ni / C catalyst, and (2) preparation of hydrogenated lecithin: dissolving lecithin in a mixed solution of dichloromethane and methanol, taking a Ni / C catalyst, filling a catalytic pipeline with the Ni / C catalyst, and carrying out a hydrogenation reaction under hydrogen flow to obtain the hydrogenated lecithin.

The invention discloses a method for preparing 1-linoleoyl lysophosphatidylcholine from ganoderma lucidum, which takes ganoderma lucidum as a material, has the advantages of wide raw material source, simple preparation method and easy realization of industrial production, provides a new way for the development of 1-linoleoyl lysophosphatidylcholine, and also provides scientific guidance for the research and development of ganoderma lucidum functional health food.

The present invention provides a phospholipid that has charge reversible properties, does not show positive charge in the pH range of a body fluid (commonly a neutral range), and shows low cytotoxicity.　The present invention provides a phospholipid represented by general formula (1) (wherein m represents a natural number of 9 to 25; n represents a natural number of 10 to 15; X1, X2 and X3 are the same as or different from one another and independently represent H or OH; and R1 represents general formula (i) or (ii)) (wherein p represents 1 or 2; q represents 1 or 2; and r represents an integer of 1 to 4) (wherein s represents an integer of 1 to 3; and R2 represents a hydrogen atom or a hydrocarbon group).

The invention discloses a lecithin puffing device for extracting egg yolk and a process thereof, and relates to the technical field of lecithin processing equipment. A safety door is arranged on the front surface of the bulking device; an electric sliding rail is fixedly mounted on the back surface of the inner wall of the bulking device; a heater is arranged in the electric sliding rail; a bulking barrel is arranged on the back surface of the inner wall of the bulking device, a safety plug is arranged on the front surface of the bulking barrel, and two limiting plates are symmetrically arranged on the back surface of the safety plug. Through revolution of the heater and the shovel roller, egg yolk lecithin is prevented from being attached to the inner wall of the puffing barrel to be coked while uniform heating puffing of egg yolk lecithin is guaranteed, the situation that the coking degree of egg yolk lecithin is gradually increased along with prolonging of heating puffing time, and consequently overall nutritional ingredients of egg yolk lecithin are reduced is avoided, powder is extracted in time, and the quality of egg yolk lecithin is improved. The whole puffing effect of the egg yolk lecithin in the puffing barrel is effectively prevented from being influenced after the egg yolk lecithin is quickly coked.

Deuterated polyunsaturated fatty acid (“PUFA”) compounds, compositions, and uses of the compounds for reducing lipid autooxidation and the treatment of various diseases and conditions are provided.

The present invention belongs to the field of extraction of microbial phospholipids, and specifically discloses a method for efficiently purifying phospholipids from coenzyme Q10 fermentation powder, which comprises the following steps: 1) mother liquor culture, 2) seed tank culture, 3) fermenter culture, 4) centrifugation of fermentation broth, 5) high-pressure homogenization, 6) centrifugation of cell lysate, 7) vacuum freeze-drying, 8) subcritical extraction, 9) acetone extraction, 10) rotary evaporation; by adjusting the medium components and optimizing the culture process, the present invention can achieve high-density culture of Agrobacterium tumefaciens cells, obtain a large amount of cells, in the fermentation broth, the coenzyme Q10 content can reach 5.1 g / L of fermentation broth, and the phospholipid content can reach 13.5 g / L of fermentation broth. Moreover, the present method also discloses a separation and purification method for efficiently extracting high-purity phospholipids from coenzyme Q10 fermentation powder, turning waste into treasure, with good economic benefits, and the steps are simple and mild, with low requirements for equipment, and are environmentally friendly.

The invention discloses a compound having the following structure of formula (I) or a stereoisomer, salt or tautomer thereof, wherein R1, R2, R3, R4, R5, R6, G1, G2, x, y, n, z and w are as defined herein. Compositions comprising the compounds and their use in methods of treating disease are also described.

The invention discloses soybean phospholipids and an extraction method thereof, and belongs to the technical field of soybean phospholipids, the extraction method of soybean phospholipids comprises the following steps: selecting fresh soybean oil leftovers as an extraction raw material, carrying out centrifugation, acetone deoiling and ethanol extraction to obtain an ethanol extraction liquid, finally adding attapulgite composite cross-linked chitosan microspheres into the ethanol extraction liquid, and carrying out centrifugation, acetone deoiling and ethanol extraction to obtain the soybean phospholipids. And further removing impurity molecules to obtain the soybean phospholipid with high stability and high soybean lecithin content. According to the present invention, by using the multiple pore structures and the electrostatic interaction of the attapulgite composite cross-linked chitosan microspheres, the impurity macromolecules and the polar inositol phospholipid, cephalin and other compounds having competitive dissolution with the soybean lecithin are separated so as to increase the soybean lecithin content in the soybean lecithin; moreover, tea polyphenol is also grafted on the attapulgite composite cross-linked chitosan microspheres, so that free radicals can be cleared through a hydrogen supply mechanism, the phospholipid oxidation process is blocked, the dual functions of high stability and high antioxidant activity are realized, and the quality of the obtained soybean phospholipid is improved.

A compound having the following structure of Formula (I): (I) or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5, R6, G1, G2, x, y, n, z, and w are as defined herein. Compositions comprising the compounds, and their use in methods of treating diseases, are also described.

This invention provides methods for culturing animal cells and related technologies. [Solution] Animal cells are cultured in the presence of lecithin.

Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

The present invention relates to the field of plant extract processing, and particularly to a preparation method of silymarin phospholipid complex and a special stirring reactor therefor. In a preparation method of silymarin phospholipid complex of the present invention, by controlling the specification / addition ratio of phospholipids in the same process, after complexing with silymarin, water precipitation is carried out, and water-soluble impurities in the raw materials are separated and removed while preparing the silymarin phospholipid complex, further increasing the content of active ingredients. A special stirring reactor for preparing silymarin phospholipid complex of the present invention has three functions of successively completing the stirring and mixing treatment of two kinds of liquid materials, the filtration treatment of precipitation and solvent, and the drying and pulverizing treatment of precipitation, realizing that multiple treatment processes are completed by one machine, saving the time consumed by material transfer in each treatment step and the equipment operation cost, and greatly improving the production efficiency of silymarin phospholipid complex.

Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Nanolipoprotein particles having at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described. The membrane lipid component includes at least one or more membrane forming lipids, one or more polymerized lipids and / or one or more polymerizable lipids.

Hydrogel materials used in the manufacture of biocompatible medical devices, for example, hydrogel materials having desirable physical properties for use as a contact lens. A composition contains at least one vinyl containing monomer, a methacrylate(acrylate) monomer, methacrylate (acrylate) prepolymers, crosslinking agents and monomers having the structure as shown in Formula 1:where R1 is a vinyl functionality capable of radical polymerization with specific preference for N-vinyl lactam derivatives and R2 is a zwitterionic functionality. The materials utilize a two-phase polymerization strategy.

The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas:wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

The invention provides powdery phospholipid with good free-running property and rich phosphatidylcholine as well as a preparation method and application of the powdery phospholipid, and belongs to the technical field of deep processing of phospholipid. According to the method, the crude phospholipid is sequentially subjected to absolute ethyl alcohol purification and acetone refining, the refining frequency is controlled, it is guaranteed that the PC content is 40 wt% or above, meanwhile, the isomaltitol is added in the last time of refining, and the isomaltitol serves as sugar alcohol which is low in hygroscopicity and easy to crystallize, so that the purity of the product is greatly improved. At the moment, a special co-dispersion system which can form with phospholipid in an acetone medium is added, and in the subsequent drying process, the phospholipid particles can be accurately filled and an isolation layer is formed, so that the physical structure of the product is fundamentally changed, and particle adhesion is prevented from internal anti-caking and internal isomaltitol is used as a skeleton; an anti-caking agent is arranged outside to serve as a'ball 'to further reduce friction, and the dual-action mechanism ensures that the final product has extremely excellent flowability and long-term storage stability.

The application belongs to the technical field of phospholipid extraction, and particularly relates to chicken bone marrow phospholipid, a preparation method and application thereof. The method comprises the following steps: freezing and drying chicken bone marrow, mixing the chicken bone marrow in a mixed solution of dichloromethane and methanol, treating the mixture by a high-energy fluid mill, centrifuging, mixing the supernatant with water, stirring, standing, obtaining lower dichloromethane and upper mixed liquid, repeatedly extracting the upper mixed liquid to obtain a dichloromethane mixed liquid, combining the dichloromethane, reducing pressure and concentrating, drying, obtaining a mixed liposome, dissolving the mixed liposome in acetone, extracting, centrifuging, drying, and obtaining chicken bone marrow phospholipid. The antioxidant capacity of the chicken bone marrow phospholipid is further determined, which provides a theoretical basis for the application of the chicken bone marrow phospholipid in drugs for diseases caused by free radicals.

The present disclosure provides an improved composition of ionizable lipid nanoparticles for delivering therapeutic nucleic acids to cells. Anionic phospholipids, including phosphatidylserine and phosphatidylglycerol, are included in lipid nanoparticles to increase transfection efficiency within human dendritic cells. Further incorporation of monounsaturated alkyl chain analogs in ionizable lipids of dimethylaminopropyl-dioxolane or heterocyclic ketal in the formulation demonstrated high levels of transfection within human dendritic cells and good stability against oxidative damage compared to other ionizable lipids of the same family. Finally, the use of the ammonium salt of phosphatidylserine enables the effective generation of PS-targeted LNPs.

Hydrogel materials used in the manufacture of biocompatible medical devices, for example, hydrogel materials having desirable physical properties for use as a contact lens. A composition contains at least one vinyl containing monomer, a methacrylate(acrylate) monomer, methacrylate (acrylate) prepolymers, crosslinking agents and monomers having the structure as shown in Formula 1:where R1 is a vinyl functionality capable of radical polymerization with specific preference for N-vinyl lactam derivatives and R2 is a zwitterionic functionality. The materials utilize a two-phase polymerization strategy.

The development of new immunoregulatory small molecules represents a significant advance in immunotherapy. Provided herein are compounds, such as compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and compositions, methods, uses, and kits that may be used in immunotherapy. The compounds provided herein are responsible for immunomodulatory signaling through the TLR2 receptor and are therefore useful for the treatment and / or prevention of various diseases (e.g., metabolic diseases, inflammatory diseases, immune disorders, or proliferative diseases).