122results about "Phosphatide foodstuff compositions" patented technology

A compound presented by the general formula (1), its racemic form, or their salt thereof (in general formula (1), X represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R1 represents R1a-Y-R1b (wherein R1a and R1b independently represent a saturated or unsaturated aliphatic hydrocarbon group, aromatic group, heterocyclic group, or a combination thereof, and Y represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom), R2 independently represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.).

The invention discloses a hydrogenated lecithin synthesis method based on a nickel catalysis continuous flow strategy, relates to the technical field of preparation of hydrogenated lecithin, and aims to solve the problem that the cost of preparing the hydrogenated lecithin is greatly increased due to the fact that the hydrogen pressure is relatively high and recycling of a catalyst is not considered in an existing method. The preparation method is technically characterized by comprising the following steps: (1) performing heat treatment on moso bamboo powder in a protective gas atmosphere to obtain a carbon carrier; dipping the carbon carrier in an alkali solution, and then carrying out a high-temperature activation reaction in a protective gas atmosphere; an activated carbon carrier is obtained; the preparation method comprises the following steps: loading a nickel source, an auxiliary agent and a structure stabilizer into an activated carbon carrier by dipping to obtain a catalyst precursor, and pyrolyzing the catalyst precursor in a protective gas atmosphere to obtain a Ni / C catalyst, and (2) preparation of hydrogenated lecithin: dissolving lecithin in a mixed solution of dichloromethane and methanol, taking a Ni / C catalyst, filling a catalytic pipeline with the Ni / C catalyst, and carrying out a hydrogenation reaction under hydrogen flow to obtain the hydrogenated lecithin.

The invention discloses a compound having the following structure of formula (I) or a stereoisomer, salt or tautomer thereof, wherein R1, R2, R3, R4, R5, R6, G1, G2, x, y, n, z and w are as defined herein. Compositions comprising the compounds and their use in methods of treating disease are also described.

A compound having the following structure of Formula (I): (I) or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5, R6, G1, G2, x, y, n, z, and w are as defined herein. Compositions comprising the compounds, and their use in methods of treating diseases, are also described.

This invention provides methods for culturing animal cells and related technologies. [Solution] Animal cells are cultured in the presence of lecithin.

The invention provides powdery phospholipid with good free-running property and rich phosphatidylcholine as well as a preparation method and application of the powdery phospholipid, and belongs to the technical field of deep processing of phospholipid. According to the method, the crude phospholipid is sequentially subjected to absolute ethyl alcohol purification and acetone refining, the refining frequency is controlled, it is guaranteed that the PC content is 40 wt% or above, meanwhile, the isomaltitol is added in the last time of refining, and the isomaltitol serves as sugar alcohol which is low in hygroscopicity and easy to crystallize, so that the purity of the product is greatly improved. At the moment, a special co-dispersion system which can form with phospholipid in an acetone medium is added, and in the subsequent drying process, the phospholipid particles can be accurately filled and an isolation layer is formed, so that the physical structure of the product is fundamentally changed, and particle adhesion is prevented from internal anti-caking and internal isomaltitol is used as a skeleton; an anti-caking agent is arranged outside to serve as a'ball 'to further reduce friction, and the dual-action mechanism ensures that the final product has extremely excellent flowability and long-term storage stability.

The application belongs to the technical field of phospholipid extraction, and particularly relates to chicken bone marrow phospholipid, a preparation method and application thereof. The method comprises the following steps: freezing and drying chicken bone marrow, mixing the chicken bone marrow in a mixed solution of dichloromethane and methanol, treating the mixture by a high-energy fluid mill, centrifuging, mixing the supernatant with water, stirring, standing, obtaining lower dichloromethane and upper mixed liquid, repeatedly extracting the upper mixed liquid to obtain a dichloromethane mixed liquid, combining the dichloromethane, reducing pressure and concentrating, drying, obtaining a mixed liposome, dissolving the mixed liposome in acetone, extracting, centrifuging, drying, and obtaining chicken bone marrow phospholipid. The antioxidant capacity of the chicken bone marrow phospholipid is further determined, which provides a theoretical basis for the application of the chicken bone marrow phospholipid in drugs for diseases caused by free radicals.

Nanoparticle compositions for delivery of nucleic acids to subjects including aminoalkyl branched lipid-like molecules as carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the nanoparticle containing are described. Also provided are methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects.

The utility model belongs to the field of phosphatidylserine production technology especially for a kind of efficient catalytic reaction kettle of preparation phosphatidylserine, including kettle body, the kettle body is by outer tube, and the inner tube of fixed connection on the inner wall of outer tube is composed, kettle body is located in the center of inner tube and is provided with stand, and stand is inserted with equidistant distribution's stirring catalytic mechanism, the stand includes the column body rotationally connected in the center of kettle body, and the outer wall of column body is along the length direction of column body and is provided with the T-shaped groove of array distribution.This utility model is through setting outer tube and inner tube, when using, the circulation of solution can be realized by circulating pipeline, conduit, liquid inlet pipe, water pump, liquid injection mechanism, so that solution reciprocating contact with enzyme catalysis board frame, avoid existing dead angle, and the mode can make that solution is heated evenly, in turn guarantee the preparation effect of phosphatidylserine, solved the device efficiency low, the problem of poor processing effect of present stage.

Nanoparticle compositions for delivery of nucleic acids to subjects including aminoalkyl branched lipid-like molecules as carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the nanoparticle containing are described. Also provided are methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects.

To provide: an edible microextruded product with compressive and tensile Young's moduli resembling the mechanical properties of meat; and a process of manufacturing the same.SOLUTION: An edible microextruded product includes one or more viscoelastic microextruded elements. The microextruded element include protein, an edible pseudoplastic polymer, and an edible solvent. The percentage by weight of the protein in relation with the total weight of the microextruded element is from 19% to 49%. The percentage by weight of the edible pseudoplastic polymer in relation with the total weight of the microextruded element is from 0.2% to 40%. The percentage by weight of the edible solvent in relation with the total weight of the microextruded element is at least 45%, the edible solvent balancing up to 100 wt.% of the microextruded element. The one or more microextruded elements have a cross-sectional width of from 10 μm to 1000 μm.SELECTED DRAWING: Figure 1A

Provided herein is ionizable phospholipid and its related compositions and methods.In some embodiments, provided herein is ionizable phospholipid can be formulated into the composition that contains nucleic acid and one or more helper excipients.In some embodiments, these compositions can also be used to treat disease or disorder with therapeutic nucleic acid.

The invention provides lipid rich in sphingomyelin, a preparation method and a phospholipid ingredient for infant formula milk powder, and relates to the technical field of dairy product processing.The lipid rich in sphingomyelin and the preparation method thereof have the advantages that primary separation is carried out by the aid of supercritical carbon dioxide extraction technologies, secondary extraction is carried out by the aid of follow-up ethyl alcohol serving as entrainer, non-polar lipid can be effectively removed, and the lipid rich in sphingomyelin can be obtained; and phospholipids with high polarity, especially sphingomyelin, are retained. The ethanol concentration is controlled to be 20% (v / v), so that the solubility and the selective extraction efficiency of lipid rich in sphingomyelin are improved, and a higher sphingomyelin enrichment degree is realized in a final product. Meanwhile, ethanol extraction can be directly combined with a freezing crystallization method, other organic solvents are not introduced into the method, the method is green and safe, complex equipment support is not needed, the technological process is short, operation is easy and convenient, cost is low, and the method is suitable for rapid preparation.

A compound is represented by Formula (I),in which each carbon atom of a glycerol backbone optionally has one or more substituents, and R1 isoptionally having one or more substituents, in which * is an oxygen atom bound to R1.

The invention relates to the non-therapeutical use of phosphatidylcholine and / or lyso- phosphatidylcholine for increasing the nutrient retention of at least one Long-Chain Fatty Acid (LCFA) in an animal or a human, or to a use of phosphatidylcholine and / or lyso- phosphatidylcholine for increasing the thermal stability of at least one Long-Chain 5 Unsaturated Fatty Acid (LC-UFA). The invention further relates to an ingestible composition, and a method of preparation of such a composition.

The present invention addresses the problem of imparting a mellow feeling to a plant-based oil-in-water emulsion. A plant-based oil-in-water emulsion which is characterized by satisfying all of the following conditions (a) to (c). (a) comprises a lipid. And (b) as a plant raw material, a plant raw material containing phospholipids treated with phospholipase. And (c) the content of the phospholipid derived from the plant raw material is 0.003% by weight or more in the oil-in-water emulsion.

Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula:or a salt thereof. R1 includes a chelating agent that is chelated to a gadolinium atom; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl; R2 is —N+H3, —N+H2Z, —N+HZ2, or —N+Z3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection / imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.

The present invention relates to an improved method for the synthesis of (S) or (R)- edelfosine ((S) or (R)-CP201).

A process for producing a triglyceride-phospholipid concentrate is provided, the process comprising: providing an egg yolk lecithin solution from the extraction of an egg yolk material with a liquid extractant, mixing the egg yolk lecithin solution with an OPO triglyceride carrier comprising 1,3-dioleoyl-2-palmitoylglycerol and having a ratio of palmitic acid in the 2-position of the triglycerides relative to the total palmitic acid in the triglycerides (SN2-C16:0) of at least 50%, and a C52 triglyceride content of at least 42 wt.%, and separating the liquid extractant from the mixture to produce a triglyceride- phospholipid concentrate comprising the OPO triglyceride carrier and egg lecithin.

The utility model discloses purification equipment for soybean phospholipid production, and relates to the field of purification equipment. The sealing device comprises a supporting adjusting box and a sealing assembly. The supporting adjusting box comprises a supporting base, a supporting barrel is arranged at the top of the supporting base, a discharging piece is arranged at the bottom of the supporting base, a supporting seat is arranged in the supporting barrel in a sliding mode, a conveying head is arranged at the top of the supporting seat, and a processing barrel is arranged at the top of the conveying head; and the sealing assembly comprises a cover plate and a side block, the cover plate is arranged at the top of the treatment barrel, and a moving plate is arranged in the side block. By adopting the design of the detachable cover plate, an operator can access the inner cavity of the tank body more easily, raw materials can be conveniently added, residues can be conveniently cleaned, or internal components can be conveniently checked and maintained, complicated tools or procedures are not needed, and the cover plate convenient to detach allows quick adjustment and configuration according to different production process requirements.

An water-in-oil emulsion composition that enables imparting binding properties and juiciness to a meat substitute processed product comprising plant raw material. The water-in-oil emulsion composition for use in a meat substitute processed product comprising plant raw material includes an emulsifier A, and an emulsifier B and / or an emulsifier C. The emulsifier A is selected from the group consisting of a polyglycerin-condensed ricinoleic acid ester, a glycerin fatty acid ester, a sucrose fatty acid ester, and a lecithin, and has an HLB of 9.0 or less. The emulsifier B is a fatty acid ester and has saturated a fatty acid as a constituent fatty acid. The emulsifier C is a fatty acid ester and has only an unsaturated fatty acid as constituent a fatty acid.

The preparation method comprises the following steps: dissolving phosphatidylserine powder prepared by enzyme reaction in vegetable oil, adding pure water, stirring until the system is in a reverse micelle gel state, vacuumizing, filling nitrogen, carrying out oil bath, rapidly stirring and heating until the system is boiled to obtain upper-layer clear and transparent oil, and filtering to obtain the phosphatidylserine oil. And cooling to room temperature, and performing centrifugal separation to obtain the transparent phosphatidylserine oiling agent. According to the invention, phosphatidylserine is dissolved in grease in a path of dissociating reverse micelles by a gasification method, so that the phosphatidylserine is in a clear and transparent state, the colloidal influence of related polar substances such as sterol glycoside is eliminated, the transparent phosphatidylserine oil agent is prepared, the use of toxic solvents is avoided, and the subsequent continuous purification and preparation application are facilitated.

This invention relates to the field of biological protein extraction technology, specifically disclosing an extraction process for marine biological proteins used for skin whitening in sensitive skin, comprising the following steps: S1, pretreatment; S2, acidic extraction; S3, enzymatic hydrolysis; S4, ultrafiltration and centrifugation. In the acidic extraction process, tannic acid, phytic acid, sulfonated soybean lecithin, and pepsin are added; in the enzymatic hydrolysis process, anthocyanins and magnesium gluconate are added. Through the synergistic effect of these processes, the purity and extraction rate of the marine biological protein are improved.

A yolk phospholipid composition having a lysophosphatidyl ethanolamine content of 1% by mass or less and an amino acid content of 50 mg / 100 g or more and 500 mg / 100 g or less.

A phospholipid-enriched milk fraction for use in preventing viral infection with respiratory syncytial virus (RSV) and / or preventing the further progression of viral infection with respiratory syncytial virus (RSV).

The present invention provides a method for producing a high-purity polyalkylene oxide-modified phospholipid. The present invention specifically provides a method for producing a specific polyalkylene oxide-modified phospholipid, the method being characterized by sequentially performing the step (A), the step (B), the step (C) and the step (D) described below. Step (A): a step in which a specific polyalkylene oxide compound and a specific phospholipid are reacted with each other in an organic solvent in the presence of an alkali metal salt, thereby obtaining a reaction product. Step (B): a step in which an inorganic adsorbent that contains at least one of elemental aluminum and elemental magnesium is added to a solution of the reaction product obtained in the step (A) and the resulting solution is stirred, thereby obtaining a polyalkylene oxide-modified phospholipid. Step (C): a step in which an organic solvent is added to the polyalkylene oxide-modified phospholipid obtained in the step (B), an aqueous solution of a polycarboxylic acid is subsequently added thereto, and the resulting solution is stirred, thereby obtaining a polyalkylene oxide-modified phospholipid solution. Step (D): a step in which an alkaline aqueous solution of a sodium metal salt is added to the polyalkylene oxide-modified phospholipid solution obtained in the step (C), and the resulting solution is stirred.

The invention relates to the field of synthetic phospholipids, and discloses a method for preparing phosphatidyl ethanolamine synthetic phospholipids under catalysis of phospholipase D. The method comprises the following steps: A, completely dissolving PC in an organic solvent to obtain a PC solution; b, adding ethanolamine into the buffer solution, and adjusting the pH value in an ice bath; c, mixing a metal salt solution with phospholipase D to obtain a fermentation enzyme solution, pouring a buffer solution containing ethanolamine, and uniformly mixing to obtain a water phase; d, mixing the PC solution with a water phase to uniformly disperse PC, and carrying out hydrolysis reaction to obtain a PE crude product reaction solution; e, standing for layering to obtain a water layer, extracting the water layer, and concentrating the obtained organic layer to obtain a PE crude product concentrate; f, refining to obtain a PE crude product I; g, performing column chromatography separation and vacuum concentration to obtain a PE crude product II with the purity not lower than 98%; f, drying to obtain a PE finished product. The method is simple in process, good in enzyme specificity, mild in reaction condition, environment-friendly, high in yield and beneficial to large-scale production of enterprises.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a synthesis method of 1, 2-difatty acyl-sn-glycerol-3-phosphatidic acid. According to the synthesis method of the liposome precursor compound 1, 2-double fatty acyl group-sn-glycerol-3-phosphatidic acid, 1, 2-double fatty acyl group-sn-glycerol-3-phosphatidic acid and phosphorus oxychloride are used as raw materials to carry out phosphorylation reaction, then hydrolysis reaction is carried out to obtain the required 1, 2-double fatty acyl group-sn-glycerol-3-phosphatidic acid, and the required 1, 2-double fatty acyl group-sn-glycerol-3-phosphatidic acid is subjected to hydrolysis reaction to obtain the 1, 2-double fatty acyl group-sn-glycerol-3-phosphatidic acid. The two-step phosphorylation-hydrolysis reaction in the whole process can be carried out under the bifunctional catalyst system, the high-efficiency catalytic reaction can be realized without replacing the catalyst, and the product conversion rate is high.

A compound having the following structure of formula (I): (I) or a stereoisomer, salt, or tautomer thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , G 1 , G 2 , x, y, n, z, and w are as defined herein. Compositions comprising these compounds and their use in methods of treating disease are also described. [Formula 1] JPEG2026502349000138.jpg31170

This disclosure relates to synthetic methods of making bioactive in vivo precursors to plasmalogen compounds and salts thereof and to making plasmalogens and their derivatives and salts thereof. This disclosure also relates to chemical precursors to bioactive compounds and salts thereof. This disclosure further relates to compositions comprising one or more compounds of this disclosure and the use of such compositions in preparing compounds useful in methods of treating diseases and conditions that are beneficially treated by administering plasmalogens or their derivatives or precursors that are transformed in vivo to plasmalogens.