46 results about "Lipid structure" patented technology

Lipid nanoparticles comprising ionizable lipids, helper lipids, neutral lipids, structural PEG-lipids, and anchor PEG-lipids are provided herein, together with targeted lipid nanoparticle compositions, and uses thereof. Methods of administering targeted lipid nanoparticles and targeted lipid nanoparticle compositions for the delivery of biologically active agents, are also provided. Such compositions and methods can be used, for example, to deliver a cargo (e.g., a mRNA cargo), to a cell population of interest.

The invention discloses a liver-protecting beverage containing a composite plant exosome with optimized antioxidant capacity. The liver-protecting beverage comprises a plant exosome solution and a liver-protecting component, the plant exosome solution is a silybum marianum exosome solution and at least two of a Pingyin red rose exosome solution, a radix puerariae exosome solution, a turmeric exosome solution and a dandelion exosome solution; the liver protection component is at least one of silybum marianum micro-capsule powder, a radix puerariae extract, corn peptide, a dandelion extract and S-acetyl-L-glutathione. Hydroxyl and amido on small molecules are combined with lipid structures on the surfaces of multiple plant exosomes, small molecule active ingredients are combined through adsorption or reaction on the surfaces of the lipid structures of the exosomes, the oxidation resistance of the product can be improved, absorption of intestinal cells and probiotics is facilitated, cell metabolism is promoted, and then the fatigue feeling is reduced.

The present application relates to a kind of single fatty chain choline phospholipid and its preparation method and application, belong to the field of biomedical materials.The single fatty chain choline phospholipid of the present application, structural formula is as shown in formula (I) or formula (II).Single fatty chain choline phospholipid can be applied in preparation of the medicament for reducing the content of lysophospholipid in human body.The single fatty chain choline phospholipid of the present application can produce strong charge interaction with lysophospholipid, and then combine with lysophospholipid in vivo, so that lysophospholipid loses lysolabine toxicity, weaken the hemolysis harm caused to red blood cell due to high concentration of lysophospholipid in vivo, thereby reduce the harm of lysophospholipid to liver disease patient lacking lysophospholipase.

The invention discloses a compound having the following structure of formula (I) or a stereoisomer, salt or tautomer thereof, wherein R1, R2, R3, R4, R5, R6, G1, G2, x, y, n, z and w are as defined herein. Compositions comprising the compounds and their use in methods of treating disease are also described.

The invention relates to the technical field of cosmetics, in particular to a preservative-free cosmetic composition for barrier repair as well as a preparation method and application of the preservative-free cosmetic composition. The invention relates to a preservative-free cosmetic composition for barrier repair, which comprises the following components in percentage by weight: 4.0-6.0% of 1, 2-pentanediol; 0.5% to 1.0% of 1, 2-hexanediol; 0.1% to 0.5% of cerayl; 0.5%-1.0% of phytosterol; 4.0%-6.0% of stearic acid; 4.0%-7.0% of hydrogenated lecithin; 0 to 0.3 percent of caryophylline; 0-0.2% of a eucommia ulmoides bark extract; and the balance of water. The composition of 1, 2-pentanediol and 1, 2-hexanediol is adopted to replace a traditional chemical preservative, and on the premise that the preservative effect is achieved, the possibility of causing skin irritation and allergy risks is reduced; ceramide and phytosterol can participate in construction of a skin barrier and supplement and repair a lipid structure of the skin barrier; stearic acid and hydrogenated lecithin form a stable emulsification basis, so that the two long-term contradictory requirements of no chemical preservative stimulation and effective barrier repair are met, and the unification of product safety and efficacy is realized.

This invention relates to a moisturizing and skin-nourishing cosmetic and its preparation method, belonging to the field of cosmetic technology. The cosmetic comprises self-regulating phase change liposomes and cosmetically acceptable excipients. The functional oil-phase self-regulating phase change liposome has a unique wall structure, consisting of a first type of phospholipid, a second type of phospholipid, and a functional oil phase permeating a bilayer formed by the two; wherein the phase transition temperature of the first type of phospholipid is 32-35℃, the phase transition temperature of the second type of phospholipid is 25-28℃, and the weight ratio of the two is 60:30 to 70:40; the functional oil phase accounts for 10-25% of the total weight of the wall material. The liposome's internal aqueous phase encapsulates a multi-component moisturizing composition. The cosmetic of this invention can adjust the release rate of moisturizing ingredients according to the slight temperature difference caused by changes in skin humidity, achieving a dynamic moisturizing effect. Simultaneously, through a biomimetic lipid structure, it synergistically repairs the skin barrier, providing long-lasting moisturizing and skin-nourishing functions.

The present application relates to a kind of fat powder for reducing weaning piglet dead rate and its preparation method and application, and the composite lipid in the preparation raw material of fat powder includes 1,3-di-oleic acid-2-palmitic acid triglyceride, 24 degrees palm oil, rice bran oil, coconut oil, linseed oil, caprylic triglyceride, capric acid triglyceride, alpha-lauric acid monoglyceride and tributyrin.The present application develops the fat acid composition close to pig milk fat structure, let piglet continue lactation period in weaning period to enable approach mainly with lipid, meet the compound energy demand of fast, medium and slow, avoid falling into energy potential difference;And the specific combination of medium and short chain fatty acids, both can improve the energy efficiency of weaning piglet, also have bacteriostatic disease characteristics, can improve the immunity of piglet, reduce the diarrhea rate.This composite lipid overcomes the problem such as piglet energy deficiency and indigestion caused by single raw material oil due to unsuitable lipid structure, can significantly reduce weaning stress, reduce the diarrhea rate and dead rate.

The invention provides a lipid nanoparticle based on taurochenodeoxycholic acid modification as well as a preparation method and application thereof. The lipid nanoparticle comprises nucleic acid and a lipid carrier encapsulating the nucleic acid, the lipid carrier is prepared from the following components in percentage by mole: 40 to 65 percent of ionized lipid, 5 to 20 percent of structural phospholipid, 20 to 50 percent of sterol component and 0.5 to 5 percent of PEG (Polyethylene Glycol)-lipid, wherein the sterol component comprises cholesterol and taurochenodeoxycholic acid. By replacing cholesterol with taurochenodeoxycholic acid, the membrane order degree and fluidity of the lipid carrier are effectively adjusted, and the targeted delivery and endosome release efficiency of LNP to liver cells is remarkably improved, so that an LNP delivery system can obtain a more remarkable and lasting Lp (a) reduction effect under the same or lower dosage; by optimizing the LNP formula, it is ensured that the LNP preparation has higher controllability and reliability in the production and storage process.

The invention relates to an organ selective regulation and control method of an ionizable lipid gene vector, which comprises the following steps: firstly, synthesizing uncoordinated ionizable lipid containing a ligand unit (such as cyclic amine), and forming ionizable lipid with different structural characteristics by selecting different tail chains, so that the ionizable lipid can directionally select liver or spleen; and metal ions are introduced into the non-coordinated ionizable lipid structure for coordination, so that the lung can be directionally selected. According to the method, nucleic acid molecules can be controllably and efficiently delivered to the liver, spleen or lung of a mouse, the method has the advantages of being simple, easy to implement and wide in universality, metal ion-ligand interaction is introduced into an uncoordinated ionizable lipid structure, charge distribution and apparent pKa of lipid nano particles are changed, and therefore the nucleic acid molecules can be efficiently and controllably delivered to the liver, spleen or lung of the mouse. The lipid nanoparticle organ is selectively converted from the liver or spleen to the lung, and ultrahigh nucleic acid molecule delivery efficiency is shown.

The invention discloses compound massage essential oil for relieving neck, shoulder, waist and leg pain and a preparation method of the compound massage essential oil, and belongs to the technical field of traditional Chinese medicine. 8 to 12% of sandalwood; 15 to 20% of frankincense; 5-8% of Chinese ilex; 12-18% of rhizoma curcumae longae; 5-8% of hypericum perforatum; 3-5% of arnica montana; 1.5% to 2.5% of Fe3O4 (at) SiO2 nano particles; 2.5%-3.5% of a photosensitive microcapsule; and 4-6% of a ceramide composite film. The Fe3O4-coated SiO2 nanoparticles are prepared by a nitrogen protection coprecipitation method, have a magnetic targeting function, and can be enriched at a pain part under the guidance of an external magnetic field; the photosensitive microcapsule realizes accurate release of active components triggered by ultraviolet light based on the photoresponse characteristic of azobenzene wrapped by gelatin-Arabic gum; the ceramide composite membrane reconstructs a stratum corneum lipid structure through cholesterol and free fatty acid synergistically, so that the macromolecular transdermal efficiency is improved, and the skin barrier is repaired; the neck, shoulder, waist and leg pain is remarkably relieved, and the device is suitable for sensitive skin and physical therapy combined scenes.

The application discloses a quantitative relationship model between lipid structure and its reversed-phase liquid chromatography retention and a retention time prediction system. The model takes the experimental retention time of a specific lipid compound as a dependent variable, takes screened specific structure characteristic parameters as independent variables, adopts an LM() function, and obtains a model as follows: Si represents the number of carbon atoms and carbon-carbon double bonds on a sphingosine skeleton, the number of carbon atoms and carbon-carbon double bonds on a sterol skeleton, and other skeletons, characteristic groups or residues; the quantitative relationship model between lipid structure and its reversed-phase liquid chromatography retention is constructed by taking screened multiple structure characteristic parameters as independent variables, and the independent variables are simplified, so that the retention time of more than ten thousand lipid compounds can be predicted R C The value of the medical health index data analysis ability can be effectively improved.

A compound having the following structure of formula (I): (I) or a stereoisomer, salt, or tautomer thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , G 1 , G 2 , x, y, n, z, and w are as defined herein. Compositions comprising these compounds and their use in methods of treating disease are also described. [Formula 1] JPEG2026502349000138.jpg31170

The application discloses a preparation method of a flaky magnetic material for enriching exosomes. The flaky Fe3O4 magnetic material with high specific surface area is taken as a starting point, and a surface of the flaky Fe3O4 magnetic material is coated with silicon dioxide to enhance dispersibility and chemical stability of the flaky Fe3O4 magnetic material, and to provide controllable silicon hydroxyl reaction sites for subsequent surface chemical modification. On this basis, amino active groups are introduced to the surface of the magnetic material through 3-aminopropyl triethoxysilane (APTES), and DSPE-SS-PEG2000-CHO containing a disulfide bond structure is further covalently connected to the surface of the magnetic material. Due to a membrane lipid insertion mechanism, non-antibody-dependent capture of a lipid bilayer exosome can be realized. The flaky magnetic material disclosed by the application shows universality and high affinity advantages, and can realize high affinity capture of a lipid structure of an exosome.

The invention relates to the technical field of biological medicine, and discloses a neutral lipid for mRNA delivery, a two-component lipid nanoparticle, a preparation method and application, and the preparation method comprises the following steps: the neutral lipid is obtained through a Ugi reaction of amine, carboxylic acid, aldehyde and isocyanide compounds; wherein the amine is polyethylene glycol-terminated amine, the carboxylic acid is a uracil carboxylic acid derivative, the aldehyde is one of C12, C18 and oleic acid chain aldehydes, and the isocyanide compound is one of C12, C18 and oleic acid chain isocyanide compounds; according to the neutral lipid structure prepared by the invention, a basic group complementary pairing delivery mechanism of uracil and polyA tail of mRNA is used for replacing a traditional model of combining electrostatic interaction of cationic lipid with mRNA, so that the problem of related inflammatory toxicity caused by cationic charges existing in ionized lipid is solved. Neutral lipid and cholesterol form novel two-component LNP, and efficient delivery of mRNA can be achieved.

The present application belongs to the technical field of dehydrating agent, and particularly relates to a dehydration reagent for biological tissue as well as a preparation method and application thereof. The dehydration reagent comprises a dehydrating agent and an infiltrating agent. The dehydrating agent comprises ethanol, and the infiltrating agent comprises glycerol. Through the synergistic dehydration effect of the ethanol-glycerol mixed solution, the short board of lipid loss caused by single ethanol dehydration is made up. The lipid structure such as cell membrane and cell organ membrane is effectively protected in the dehydration process and is no longer excessively extracted, so that the full form of the cell is maintained, and the volume of the whole brain parenchyma remains stable after dehydration, effectively reducing the volume shrinkage of the biological tissue and maintaining the morphological stability.

The invention relates to the technical field of plant extracts, and particularly discloses a preparation method of a cell pathway activation composition for tightening and lifting skin, which comprises the following steps: preparing a water-phase gel matrix and an oil phase, and then mixing to obtain massage cream with a lamellar liquid crystal gel structure. High-efficiency permeation is realized by virtue of certain similarity with a skin cuticle intercellular lipid structure; meanwhile, various plant extracts are adopted in the formula of the composition, the problem that nutrient substance transportation of facial skin is not smooth due to low cell pathway efficiency is solved by regulating and controlling the cell pathway, and the skin loosing and droop can be relieved in time; meanwhile, the skin elasticity is improved for a long time by stimulating fibroblast proliferation and promoting collagen synthesis; in addition, the composition adopts a protective agent integrating three functions of oxidation resistance of catechin, chelation of phytic acid and physical barrier of a polymer skeleton, so that the protectiveness of plant extracts is improved.

The disclosure provides a sub-micron particle comprising a first payload molecule, a lipid structure and a plurality of amphiphilic polymer chains surrounding the lipid structure. The first payload molecule is a macromolecule, optionally a nucleic acid. Additionally, the hydrophobicity of the amphiphilic polymer chains changes in response to an external stimulus.

The present invention relates to a cosmetic material composition for improving the skin barrier by reducing a packing distance in a lamellar lipid structure of the skin barrier, improves the structure of the skin barrier so that lipid layers are densely arranged, protects the skin from external irritation, and provides the effect of effectively retaining moisture.

The invention provides a cationic lipid, a liposome, a lipid nanoparticle and application. The cationic lipid has a structure as shown in a general formula (I). The novel cationic lipid structure provided by the invention contains a conjugated structure, so that good wrapping efficiency on messenger ribonucleic acid drugs and an excellent in-vivo delivery effect are realized.

This invention belongs to the field of veterinary drug technology. Specifically, it discloses a synergistic var. fluoraranil-moxicillin drop containing plant essential oils. The plant essential oils in the drop can disrupt the lipid structure of the parasite's epidermal wax layer, reduce the epidermal barrier function, increase epidermal permeability, and promote the rapid penetration of fluoraranil and moxicillin into the parasite, thereby increasing the drug concentration and shortening the onset time. At the same time, it also helps to enhance the effect of transdermal penetration enhancers. Fluoraranil acts on the parasite's GABA-gated chloride ion channels, moxicillin acts on the parasite's neuromuscular junction, and the plant essential oil exerts its insecticidal effect by disrupting the parasite's cell membrane integrity and inhibiting its metabolic enzyme activity. The three have different targets and no cross-resistance. They can synergistically block the key survival links of parasites, significantly improve the insecticidal rate, and delay the development of parasite resistance to single drugs.

The present invention relates to a lipid complex for the nasal delivery of nucleic acid molecules comprising ionized lipids, structural lipids, cholesterol, and lysoPC as active ingredients. The lipid complex of the present invention can be usefully utilized for the local and intensive delivery of therapeutic nucleic acid molecules specifically to nasal epithelial cells by efficiently being compatible with the microenvironment unique to nasal tissue, easily penetrating the mucus layer barrier, and effectively escaping endosomes. Furthermore, the lipid complex of the present invention can be applied as a combination administration platform that induces a synergistic therapeutic effect by two pharmacological components by loading additional drugs into internal compartments of the lipid complex, as well as improving dispersibility by loading the target nucleic acid molecule externally.

The application belongs to the field of biological medicine, and provides a biodegradable amino acid derivative ionizable lipid, a preparation method and application thereof. The lipid structure comprises an amine group head group, an amino acid core connecting part and a hydrophobic lipid tail chain. The prepared lipid nanoparticle formula comprises the above amino acid lipid, a phospholipid, a PEG lipid, an auxiliary lipid and a nucleic acid drug, can safely and efficiently transfect the nucleic acid into cells, and has a wide application prospect in the field of nanometer nucleic acid vaccines, nucleic acid drug preparations and other gene therapies.

The invention relates to the technical field of liquid perfumed soap, and discloses liquid perfumed soap and a preparation method thereof, and the liquid perfumed soap comprises the following components: 8-15% of a main surfactant; 10%-15% of milk; 15%-20% of oat milk; 0.6%-2.5% of a pH buffer agent; 4.5%-10% of an active ingredient composition; 0.05%-0.5% of a preservative and the balance of deionized water. The main surfactant is selected from one or more of sodium cocoyl methyl taurate, sodium lauroyl glutamate and sodium lauroyl sarcosinate. The perfumed soap is prepared by adopting a plant organic component formula, the technical formula that the main active component of the traditional liquid perfumed soap is a chemical surfactant and various auxiliaries are added is replaced, green and environment-friendly organic compounding is realized, and the defects that the conventional surfactant causes skin irritation and barrier damage, possibly damages a skin cuticle lipid structure and causes skin irritation and barrier damage are overcome. The problems of dryness, itching or sensitivity are caused.

The application relates to a preparation method and application of a tumor microenvironment-based sequence response covalent nanomaterial. The preparation method comprises the following steps: S1, synthesizing a lipid structure dodecyl succinic anhydride-phosphotyr P-Ty; and S2, preparing the tumor microenvironment-based sequence response covalent nanomaterial TP NPs. The new nanometer preparation with sequence response alkaline phosphatase and hydrogen peroxide can potentially overcome non-specific aggregation of the nanometer preparation, improve enrichment of the nanometer preparation in a tumor lesion, enhance the killing property of the nanometer preparation on tumor cells by constructing ultra-small platinum clusters, and can be used for overcoming drug resistance of the tumor cells.

The application provides eight new ionizable lipid compounds, and belongs to the field of biological medicines. Compared with existing ionizable lipid structures, the ionizable lipid compounds provided by the application all have primary amine groups, and the ionizable lipid compounds can be prepared into lipid nanoparticles to deliver nucleic acids or other drugs. Compared with traditional lipid nanoparticles, the nucleic acid encapsulation rate and delivery efficiency of the lipid nanoparticles provided by the application are higher, and the transfection cell specificity of one kind of the lipid nanoparticles is higher, and seven kinds of the lipid nanoparticles can effectively transfect various cells and have a certain broad spectrum. In summary, the eight ionizable lipid compounds provided by the application can be applied to the fields of nucleic acid drug delivery and vaccines as new carrier functional reagents.

This application provides an antimicrobial peptide or peptide derivative, substitute, and compositions thereof, preparation methods, and applications thereof, comprising at least one of the following amino acid sequences I and II: Amino acid sequence I: X a1 B a1 U1Z1B a2 X a2 B a3 Z a2 B a4 X a3 Amino acid sequence II: where X a1 B a1 U1, Z a1 B a2 X a2 B a3 Z a2 B a4 X a3 X b1 B b1 C a1 Z b1 B b2 X b2 B b3 Z b2 B b4 X b3 C a2 Each peptide is independently selected from natural amino acids and / or non-natural amino acids. Among them, the antimicrobial peptides or peptide derivatives provided in this application can bind to the lipid structure of cell walls / membranes, damage their physicochemical properties, destroy microbial walls, and thus kill microorganisms and tumor cells. In addition, they also have the effects of external wound disinfection and anti-infection.

The invention provides an oil-soluble polypeptide composition containing camellia polypeptide and having a cellular-grade anti-aging effect as well as a preparation method and application of the oil-soluble polypeptide composition, and particularly relates to the technical field of cosmetic intermediates. The outside of the oil-soluble polypeptide composition is coated with a phospholipid membrane, and a polypeptide-supramolecular complex is embedded into the phospholipid membrane; the polypeptide-supramolecular complex is obtained by coating a supramolecular solution of polypeptide with first phospholipid and then freeze-drying. The oil-soluble polypeptide composition realizes efficient solubilization and stable loading of polypeptide in a pure oil system. Polypeptide is dissolved by a supramolecular solvent and freeze-dried to form a polypeptide-supramolecular complex, so that exposure of hydrophilic groups of the polypeptide-supramolecular complex is remarkably reduced, and fat solubility is improved; the outer phospholipid membrane not only forms a compact hydrophobic protective barrier, effectively isolates a water-phase environment, inhibits degradation reactions such as hydrolysis and oxidation of polypeptide and improves chemical stability and shelf life, but also serves as a lipid material with excellent biocompatibility, enhances affinity of the composition and a skin cuticle lipid structure and synergistically promotes transdermal permeation of polypeptide.

The present invention relates to the field of biomedicine, and specifically relates to an ionizable lipid and the use thereof. The ionizable lipid has the structure as represented by formula (I). Lipid nanoparticles constructed by using the ionizable lipid of the present invention can realize the safe and efficient delivery of nucleic acid drugs, small molecule drugs, peptide drugs and protein drugs.