The invention discloses a Yangtze river system eriocheir sinensis compound feed, which is prepared from the following materials: fish meal, bean pulp, cottonseed meal, rapeseed meal, peanut meal, corn germ meal, cuttlefish paste, shrimp meal, soybean phosphatide powder, soya-bean oil, fish oil, lard oil, monocalcium phosphate, high protein flour, shell pigment, trace elements for crab, complex vitamins for crab, choline chloride, a binder, zeolite powder, bacillus licheniformis premix, and astragalus polysaccharide premix. The preparation method of the Yangtze river system eriocheir sinensis compound feed comprises the steps of: mixing materials twice, evenly mixing, pelletizing, keeping warm, cooling, sieving, packaging and the like. The Yangtze river system eriocheir sinensis compound feed can enhance the disease resistance of the eriocheir sinensis, quickens the growth speed of the eriocheir sinensis, enriches crab roe and crab cream, improves the nutritive value of the eriocheir sinensis, increases production and improves productivity for a farmer. The digestion and absorption efficiency of the eriocheir sinensis on the materials can be effectively strengthened, and the stability of particles in water is strong.