The invention discloses a jewfish fish meal-free high efficiency safety mixed feed, which comprises the following components: 5-10 parts of chicken powder, 2-6 parts of pork powder, 5-15 parts of soy protein concentrate, 2-8 parts of fermented soybean meal, 2-7 parts of corn gluten meal, 12-25 parts of krill meal, 5-10 parts of cuttlefish powder, 1-5 parts of silkworm chrysalis powder, 3-6 parts of mussel housefly larvae enzymatic hydtolysis peptide powder , 3-5 parts of probiotics fermentation small peptide mixture, 1-3 parts of molasses extract yeast, 1-3 parts of seaweed meal, 12-18 parts of high gluten wheat flour, 1-4 parts of refine fish oil, 1-3 parts of refine soya-bean oil, 2-5 parts of soybean phosphatide oil, 0.1-0.4 parts of choline, 0.2-0.5 parts of composite vitamin, 1-3 parts of composite mineral matter, 1-3 parts of calcium dihydrogen phosphate, 1-2 parts of calcium lactate, 2 parts of traditional Chinese medicine compound preparation, 2 parts of premix and 2 parts of additive. The feed has the characteristics of no fish meal, fast growth, low bait coefficient, good stability in water, fast ingestion, low feeding cost, high efficiency and safety.