564 results about "Betaine" patented technology

The invention relates to a betaine phosphate-containing feed additive for improving net energy level and a preparation method and application thereof, and belongs to the technical field of feed additives, the preparation method comprises the following steps: preparing composite betaine phosphate, preparing composite zinc methionine, and mixing; the preparation of the composite betaine phosphate comprises the following steps: preparing a betaine phosphate crude product, preparing a composite silicon dioxide carrier, and crystallizing; the preparation of the compound zinc methionine comprises the following steps: preparing an activated silicon dioxide carrier, adsorbing starch and adsorbing the zinc methionine; in the step of mixing, the compound betaine phosphate and the compound zinc methionine are mixed and then stirred at room temperature, and the betaine phosphate-containing feed additive capable of improving the net energy level is obtained. The feed additive prepared by the invention has a strong effect of improving the net energy level of broiler chickens, is not easy to have the problems of bonding and clustering, and is good in storage resistance.

The present invention provides an organic phosphonic acid betaine and a preparation method thereof, specifically an ammonium phosphonic acid betaine containing a glycidyl group. The organic phosphonic acid betaine can be used as a functional monomer for free radical grafting modification of the surface of a polymer material such as polyolefin, or can be mixed with acrylate, acrylonitrile or other olefin monomers for copolymerization to prepare an amphoteric ionomer. The organic phosphonic acid betaine can also be used for ring-opening grafting modification of polymer materials such as starch, cellulose, polyurethane, and polyamide containing amino or hydroxyl groups in their structures. At the same time, the phosphonic acid betaine imparts functional effects such as zwitterionization, hydrophilicity, antibacterial properties, and antifouling properties to the obtained polymer material. The organic phosphonic acid betaine also has high chemical stability in acidic and alkaline water environments.

The invention discloses a zwitter-ion modified acrylate dielectric elastomer film and a preparation method thereof. Zwitter-ions can be selected from sulfobetaine methacrylate (SBMA), carboxyl betaine methacrylate (CBMA), sulfobetaine acrylamide (SBAA) and the like. The acrylate monomer can be butyl acrylate (BA), dodecyl acrylate (LA), isoamyl acrylate (EHA) and the like. Zwitterions (special compounds which simultaneously carry equal positive and negative charges on the same molecule and are electrically neutral on the whole) are copolymerized into an acrylate dielectric elastomer through photo-initiated free radical polymerization reaction, zwitterionic clusters uniformly distributed in the dielectric elastomer can construct traps for capturing high-energy electrons, the leakage current of the material is reduced, and the dielectric property of the material is improved. And the intrinsic breakdown field strength of the material is improved. In addition, the mutual attraction effect between dipole ions with positive and negative charges in the structure provides driving force for intrinsic self-repairing. And after being electrically and mechanically damaged, the material can be self-recovered, so that the service life of the material is prolonged.

The invention provides a betaine succinate eutectic crystal as well as a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. The structural formula of the succinic acid betaine eutectic crystal is shown as a formula I, the molecular formula of the succinic acid betaine eutectic crystal is C28H56N4O16, in the succinic acid betaine eutectic crystal, the molar ratio of succinic acid to betaine is 1: 2, and the succinic acid betaine eutectic crystal has low irritation and excellent effects.

The invention discloses a fracturing imbibition system for refracturing a low-permeability tight oil reservoir and a preparation method of the fracturing imbibition system, and belongs to the technical field of fracturing fluids, the fracturing imbibition system comprises: an acid liquid base fluid: hydrochloric acid, hydrofluoric acid, EDTMPS and deionized water; an amphoteric betaine viscoelastic surfactant; biologically modifying the nanoparticles; a Gemini cationic surface active agent; a corrosion inhibitor; and an organic silicon defoaming agent and a fluorocarbon discharge aiding agent. According to the fracturing imbibition system, through the integrated design of the multifunctional surfactant, the problems that a traditional acid fracturing fluid is insufficient in silicate mineral dissolving capacity, high-temperature viscosity is attenuated, and corrosion inhibitor dependence is caused are solved.

The invention discloses a high-reflection magnesium phosphate / aluminum phosphate radiation refrigeration material and a preparation method thereof, and relates to the technical field of radiation refrigeration materials. The preparation method of the high-reflection magnesium phosphate / aluminum phosphate radiation refrigeration material comprises the following steps: (1) mixing aluminum sec-butoxide and deionized water to prepare a solution A; mgCl2. 6H2O and deionized water are mixed to prepare a solution B; mixing the solution A and the solution B to obtain a solution C; (2) adding 3-sulfopropyl tetradecyl dimethyl betaine into the solution C to obtain a solution D; (3) stirring sodium pyrophosphate and deionized water into a solution E; mixing the solution E and the solution D to obtain a solution F; and (4) reacting the solution F at 150-180 DEG C, cooling, freeze-drying and grinding to obtain H, heating H to 300-400 DEG C at the rate of 3-4 DEG C / min, then heating H to 800-1300 DEG C at the rate of 7-10 DEG C / min, and keeping the temperature for 1-3 hours to obtain the product. The material prepared by the invention has excellent sunlight reflectivity and excellent mid-infrared emissivity, and shows excellent performance in the field of radiation refrigeration.

The present application provides the use of betaine in preventing the occurrence of autism spectrum disorder (ASD). Specifically, the present application provides the use of betaine or a pharmaceutically acceptable salt, stereoisomer, tautomer, nitroxide, solvate, metabolite or prodrug thereof in the preparation of a medicament for preventing the occurrence of ASD, optimizing fetal neural development or reducing the risk of fetal neural development disorder. By using betaine or a pharmaceutically acceptable salt, stereoisomer, tautomer, nitroxide, solvate, metabolite or prodrug thereof as an active ingredient, the occurrence of ASD can be effectively prevented, fetal neural development can be optimized, or the risk of fetal neural development disorder can be reduced.

The invention relates to the technical field of microbial fermentation, in particular to a fermentation medium for producing oxytetracycline. According to the fermentation culture medium, a corn starch-molasses-wheat hydrolyzed sugar composite carbon source, a soybean cake powder-corn steep liquor-yeast extract composite nitrogen source and a choline chloride-betaine-L-lysine precursor accelerant in a specific proportion are used as a core innovative system, and a form regulating agent, a defoaming agent and inorganic salt are cooperatively added. Through the synergistic effect of multiple components, the fermentation titer and yield of oxytetracycline are remarkably improved, the fermentation period is shortened, the generation of heteroacid is effectively inhibited, the mycelium form is optimized, and the oxytetracycline fermentation medium is suitable for industrial large-scale production of oxytetracycline.

The invention relates to the technical field of blood purification materials, in particular to a zirconium-titanium bimetal MOF hollow microsphere adsorbent and a preparation method and application thereof. The adsorbent is based on a Zr / Ti bimetallic node and a phosphonic acid-carboxylic acid mixed ligand, a composite MOF hollow microsphere structure with high stability and high specific surface area is constructed through a solvothermal and polymerization synergistic reaction in a water-in-oil suspension system, a phosphonic acid group and Zr are strongly coordinated to improve the stability of a framework, and the composite MOF hollow microsphere structure has a high specific surface area. The carboxylic acid group keeps the hydrophilicity of the pore channel; meanwhile, a cross-linked network of acrylamide and N, N '-methylene bisacrylamide penetrates through crystal gaps in the balling process, so that the material has excellent mechanical strength and fluid stability; and a sulphobetaine amphoteric polymer brush layer is constructed on the surface of the MOF through endogenous initiation point modification and surface in-situ controllable free radical polymerization technologies, so that protein adsorption and platelet adhesion are effectively inhibited, the blood compatibility is remarkably improved, and meanwhile, the channel accessibility is maintained to promote rapid diffusion and adsorption of bilirubin.

The application discloses a kind of marine reinforced concrete crack fast self-repairing agent and preparation method thereof, the self-repairing agent includes the following components by mass fraction: polyacrylic acid hydrogel 20-30%, microorganism 5-10%, betaine 20-30%, calcium salt 15-25%, aluminum salt 20-30%.Its preparation method is: acrylic acid monomer is mixed with crosslinking agent, initiator, auxiliary crosslinking agent;Aluminum salt, acrylic acid are mixed to obtain aluminum acrylate;The two are mixed with microorganism and betaine, stirring and heating, and microorganism-polyacrylic acid hydrogel is prepared;After drying, it is broken, and calcium salt powder is wrapped, then immersed in polymer emulsion, dried, and prepared.The application can quickly block cracks by forming organic-inorganic composite repair products, solidify harmful media, release beneficial ions, achieve the dual goal of crack self-repairing and reinforcement corrosion inhibition.

The invention relates to a modified cellulose additive for a coating and a preparation method thereof. The preparation method comprises the following steps: preparing titanium dioxide sol; reacting hydroxyethyl cellulose with anhydride to obtain a modified cellulose dispersion liquid; titanium dioxide sol and the modified cellulose dispersion liquid are mixed to obtain composite dispersion liquid, and fluorine-containing and silicon-containing reactive monomers and methyl methacrylate are used as monomer pre-emulsion to be polymerized in the composite dispersion liquid. The surface of cellulose is grafted with chlorinated betaine to provide antibacterial and anti-fouling properties, the prepared nano titanium dioxide sol improves the ultraviolet shielding property, and the chlorinated betaine and the nano titanium dioxide sol can realize uniform physical mixing and adsorption through intermolecular hydrogen bond acting force, hydrogen bond interaction and the like; a hydrophobic monomer prepolymer is polymerized on the surface of a compound to form a core-shell structure, so that the compactness of the composite material is further improved, a polymer chain on the surface contains rich siloxane and can be effectively compounded with resin in a coating after being added into the coating, and a water dispersion emulsion form can be compatible with various water-based resin systems and is not easy to agglomerate.

The invention discloses a pH-responsive alkaline clean fracturing fluid as well as a preparation method and application thereof, and belongs to the technical field of oil and gas field fracturing. The cleaning agent comprises the following components in parts by mass: 1-5 parts of an anionic surfactant, 1-5 parts of a zwitterionic surfactant, 0.2 part of a pH regulator and 100 parts of deionized water, wherein the anionic surfactant is sodium oleate or sodium stearate; the zwitterionic surfactant is erucyl amide propyl betaine or oleamide propyl betaine; and the surfactant is a surfactant. The pH regulator is any one of sodium hydroxide, potassium hydroxide and sodium bicarbonate. The fracturing fluid is a clean fracturing fluid system based on pH response type micelle dynamic reconstruction, and through the synergistic effect of a specific surfactant and a pH response mechanism, accurate and rapid regulation and control of viscosity, zero residue damage and construction process simplification are achieved; the technical problems that an existing surfactant fracturing fluid is complex in compounding process, cannot be recycled after gel breaking, is slow in gel breaking response and narrow in application range are solved.

The invention relates to a detergent capable of removing oil stains and pesticide residues and a preparation method of the detergent, and belongs to the technical field of daily chemical products. The detergent disclosed by the invention is prepared from the following raw materials in parts by weight: 0.4 to 1.7 parts of chelating agent, 250 to 450 parts of water, 70 to 150 parts of sodium alcohol ether sulphate, 20 to 60 parts of dodecyl glucoside, 10 to 40 parts of cocamidopropyl betaine, 10 to 55 parts of nonionic surfactant, 0.2 to 3.5 parts of plant essential oil, 0.2 to 5 parts of glycerol and 1 to 10 parts of sodium chloride. According to the present invention, the good oil stain removing and pesticide residue removing effects are achieved while the less components are utilized; due to the fact that the components are few, the residual risk of the detergent is lower, the risk of harms to human bodies is lower, and pollution to the environment is smaller; the invention provides a better choice for people who increasingly pursue safety and environmental protection, and better caters to the market demand and the national policy of environmental protection.

The invention discloses an acid and alkali resistant nanofiltration membrane and a preparation method thereof, and relates to the technical field of nanofiltration membranes. The nanofiltration membrane with better acid resistance and alkali resistance is prepared by combining a surfactant, click chemistry reaction and a metal organic framework; zirconium chloride is used as a metal node, 2-amino p-benzoic acid is used as an organic ligand, a Zr-MOF metal organic framework is constructed by adopting a solvothermal method, sulfydryl is introduced, pentaerythritol triacrylate and octyldithiol in a grafting solution are combined, free radical polymerization is carried out under UV illumination, and a high-crosslinking-degree network is formed; the charge repulsive effect of the sulphobetaine monomer realizes efficient screening of ions or molecules; a gradient ultraviolet polymerization process is adopted, and the ultraviolet intensity and density are dynamically adjusted, so that the surface flatness of the nanofiltration membrane and the uniformity of pore size distribution are improved; through chemical component design and process optimization, the mechanical property and chemical property stability of the nanofiltration membrane are synergistically improved.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for monitoring a baicalein-betaine eutectic process based on terahertz spectroscopy, and the method comprises the following steps: mixing and ball-milling baicalein and betaine to obtain powder samples, collecting the powder samples with different ball-milling times, drying, mixing with a dispersing agent, tabletting, and drying to obtain the baicalein-betaine eutectic crystal. The method comprises the following steps: measuring spectral data by using terahertz time-domain spectroscopy equipment, selecting a characteristic peak and tracking intensity change to obtain a curve, carrying out nonlinear fitting on the curve, obtaining a molecular vibration mode through a density functional theory, and analyzing the eutectic process by combining the two modes. The terahertz spectrum technology is combined with theoretical calculation, complete analysis of the baicalein-betaine eutectic process from macrodynamics monitoring to microcosmic molecular action mechanism analysis is achieved, and an effective means is provided for eutectic formation research and process optimization.

The invention discloses a preparation method and application of a betaine-induced branch structure CoFe-based catalyst, and relates to a preparation method and application of a CoFe-based catalyst. The technical problem that an existing CoFe-based catalyst is poor in activity and stability is solved. The preparation method of the betaine-induced branched structure CoFe-based catalyst comprises the following steps: immersing clean foamed nickel into an isopropanol-water heterogeneous solution containing Co < 2 + > and Fe < 2 + > for in-situ growth, then introducing betaine to induce to form a branched structure, and anchoring an acidic group on the surface of a CoFe matrix to enhance the structural stability; the alkaline group faces an electrolyte interface under the action of an electric field, regulates interface charge distribution, selectively adsorbs part of Cl <-> and repels the other part of Cl <-> at the interface, so that chlorine evolution side reaction is inhibited. When the industrial-grade current density is 500 mA cm <-2 > during seawater hydrogen production, only 280 mV overpotential is needed, and stable operation can be carried out for more than 1000 h. The method can be used in the seawater hydrogen production field.

The present invention provides a dispersant for carbon nanotubes that can effectively disperse carbon nanotubes in a solvent. [Solution] The dispersant for carbon nanotubes contains polysaccharides and betaines.

The invention discloses a cement-based material for immobilizing anionic pollutants and a preparation method thereof, and the preparation method comprises the following steps: dissolving biochar obtained by biomass pyrolysis in deionized water, adding a betaine solution, stirring to obtain a mixed solution, washing, filtering and drying the mixed solution to obtain modified biochar, and drying the modified biochar to obtain the cement-based material for immobilizing anionic pollutants. And adding the modified charcoal into a cement material to obtain the modified charcoal cement-based material. Therefore, by introducing the modified biochar containing quaternary ammonium functional groups on the surface into a traditional cement-based system, the modified biochar can generate electrostatic adsorption with anionic pollutants in the cement-based material, so that the anion adsorption efficiency is effectively improved, and the immobilization ability of the curing material on various anionic heavy metals is remarkably enhanced; and the migration and leaching risks of the compound in the environment are reduced.

This application discloses a composite oil displacement system and its preparation method, belonging to the field of oilfield development technology. The composite oil displacement system provided in this application includes rhamnolipin and betaine surfactant, wherein the rhamnolipin is a biosurfactant obtained by culturing *Pseudomonas aeruginosa*. Both the rhamnolipin biosurfactant and the betaine surfactant are heat- and salt-resistant; therefore, the composite oil displacement system prepared using the rhamnolipin biosurfactant and the betaine surfactant has good compatibility with high-temperature, high-salinity reservoirs, meaning it is suitable for such reservoirs. Therefore, it can significantly improve the oil displacement effect in high-temperature, high-salinity reservoirs.

The invention relates to the technical field of biological medicines, and particularly discloses application of betaine in preparation of a medicine for preventing or treating sepsis myocardial injury. Betaine (BET) provided by the invention can be used for effectively relieving cytokine storm caused by sepsis injury and inhibiting reduction of core body temperature of a mouse; the abnormal blood routine and blood biochemical indexes are improved. In addition, betaine can reduce generation of active oxygen in myocardial cells of the HL-1 mouse and improve mitochondrial membrane potential imbalance of the myocardial cells of the HL-1 mouse. The chemical structural formula of the betaine is shown in the specification.

The present application relates to the field of frother, in particular to a kind of copper flotation collector frother and preparation method thereof, by weight parts, including the following raw materials: N,N-dibutyl dithiocarbamic acid propyl cyanurate 100-120 parts, O-butyl-N-isobutyl thiopropyl carbamate 12-18 parts, xanthate 12-18 parts, phosphate ester polypropylene glycol ether 15-20 parts, modified betaine 5-8 parts, alcohol ether 3-5 parts, slime inhibitor 1-3 parts, alcohol ether carboxylate 2-5 parts, sorbitan monooleate 0.8-1.2 parts. Through the synergies of each raw material, the collector capacity, selectivity in copper flotation process can be effectively improved, and the reagent stability is good.

The invention discloses a long-fragment PCR (Polymerase Chain Reaction) amplification reaction solution and application thereof. The PCR amplification reaction solution is composed of a 2XPCR buffer solution, dNTP, LA Taq enzyme, betaine and distilled water. In the PCR amplification reaction liquid, the volumes of the 2XPCR buffer solution, the dNTP, the LA Taq enzyme, the betaine and the distilled water in the total volume of 25l are respectively 12.5 l, 5.0 l, 0.25 l, 4.0 l and 0.45 l. According to the present invention, the PCR amplification reaction liquid can effectively amplify the long fragment PCR product, the product amplification with the longest detection reaching 12 kb can be used for the detection of the hemophilia A intron 22 inversion, the effective amplification reagent is provided for the long fragment PCR amplification, and the problem of difficult long fragment amplification is solved.

The present application relates to a kind of methane catalytic combustion catalyst and its preparation method, comprising (1) TiO2 is ultrasonically dispersed in anhydrous ethanol, hydroxyl sulfopropyl betaine is added, and mixture is prepared;(2) the mixture of step (1) and active metal salt solution are mixed and reacted;(3) after reaction, the precipitate is separated, and TiO2@ABO3 core-shell catalyst is obtained after drying and calcination.The perovskite core-shell catalyst provided by the present application is used for the catalytic combustion of methane, T 90 ≤500 ℃, with the advantages of low-temperature catalytic activity, good stability, low cost and the like.

The present application belongs to the field of agricultural technology, and particularly relates to a composition for improving salt tolerance of plants and application thereof. The present application applies auxin (in the form of aqueous solution or powder), an aqueous solution of auxin and proline, an aqueous solution of auxin and betaine, an aqueous solution of auxin-proline-betaine ternary complex to plants by foliar spraying or root irrigation. Experiments have proved that auxin can quickly promote the sodium ion efflux of plants, reduce the sodium ion content in plants, and significantly improve the salt tolerance; the above-mentioned complex treatment can produce a synergistic effect, and further improve the growth of plants in a high-salt environment. The composition provided by the present application can be used as a plant salt tolerance promoter in field production, has a remarkable effect on enhancing the adaptability and stress resistance of plants to salt-affected land, has strong practicability, and has good popularization and application value.

The invention discloses a blue copper peptide composition for repairing scars and a preparation method of the blue copper peptide composition, and belongs to the technical field of preparation of biological medicine preparations. The composition is prepared from freeze-dried powder of copper blue peptide, polyquaternium-73, asiaticoside, nicotinamide, polydimethylsiloxane, betaine-propylene glycol ionic liquid and a gel matrix. According to the invention, the blue copper peptide is coated in a permeation enhancing system constructed by the betaine-propylene glycol ionic liquid and the HEPES, so that the enzymolysis loss of the blue copper peptide is reduced, and the biological activity of the blue copper peptide is maintained; a temperature-sensitive gel matrix is constructed by carboxyl esterified modified sodium alginate and poloxamer, the carboxyl esterified modified sodium alginate is prepared by grafting n-butyl alcohol to a hydrophilic main chain of sodium alginate through a Fischer esterification method, the gel matrix is in a liquid state at normal temperature, after the gel matrix is smeared on a scar part, the gel matrix is converted into semi-solid gel under the influence of body temperature, and slow and continuous release of blue copper peptide can be achieved. The traditional Chinese medicine composition has the effect of repairing scars and is suitable for chronic scars needing long-term nursing.

The invention discloses self-adhesion anti-water-loss gelatin ionic gel with high ionic conductivity as well as a preparation method and application of the self-adhesion anti-water-loss gelatin ionic gel, and belongs to the technical field of polymer ionic gel. The self-adhesion anti-water-loss gelatin ionic gel with high ionic conductivity is prepared from gelatin and a non-aqueous solvent, wherein the non-aqueous solvent is a choline chloride-sodium pyrrolidone carboxylate non-aqueous solvent or a betaine-sodium pyrrolidone carboxylate non-aqueous solvent. In the preparation process, water is not added as a solvent, water loss is not likely to happen in the use process, and the stability of mechanical performance and electrical performance is easy to maintain; the gelatin ionic gel prepared by the invention has the characteristics of water loss resistance, self-adhesion, reusability, ionic conductivity, in-situ polymerization, patterning and the like, can conformally form gel on the surface of skin through an in-situ polymerization method, and has the advantages of high skin adaptability, good stretchability, high sensitivity, capability of being directly written by ink for patterning and the like.

The invention provides a nutrition regulator based on bioactive substances and a preparation method of the nutrition regulator based on the bioactive substances. Comprising the following raw materials in parts by weight: 10-20 parts of zymosan, 15-25 parts of fulvic acid, 20-30 parts of a high-activity carbon source, 5-10 parts of compound biological enzyme, 8-15 parts of algae auxin, 8-12 parts of compound probiotics, 3-8 parts of betaine, 15-25 parts of compound mineral elements and 5-10 parts of compound trace elements. According to the nutrient regulator, the algae auxin is formed by compounding the undaria pinnatifida fermentation product, the pomegranate peel fermentation product and the enteromorpha fermentation product, the undaria pinnatifida fermentation product promotes diatom growth, the enteromorpha fermentation product promotes green algae growth, the pomegranate peel fermentation product can inhibit growth of harmful algae such as blue-green algae, and the nutrient regulator has a synergistic effect on the algae auxin. Therefore, the proportion of beneficial algae such as diatom is increased and maintained for a long time, stable, efficient and high-quality water color beneficial to culture is formed, and the productivity structure of the pond is fundamentally optimized.

The invention relates to the technical field of concrete crack repair, in particular to an electro-deposition repair assistant and an electro-deposition repair method for concrete cracks, and the electro-deposition repair assistant is composed of a solid component A and a solid component B which are independently packaged; the solid component A is prepared from the following raw materials: beta-cyclodextrin and boric acid; the solid component B is prepared from the following raw materials: lauryl sodium sulfate and sulphobetaine; the mass ratio of the solid component A to the solid component B is 1: 1. According to the invention, the deposition uniformity of zinc ions in concrete cracks is remarkably improved through the electro-deposition repairing auxiliary agent, so that a uniform and compact deposition layer is formed at the repaired cracks, the integrity and stability of a concrete structure are effectively enhanced, meanwhile, the formation of zinc dendrites is inhibited, the defects of the repairing layer and the structural damage caused by the growth of the zinc dendrites are reduced, and the service life of the concrete is prolonged. And the repairing quality and durability are improved.

The invention discloses a chloroacetic acid modified epoxy resin precursor. The structure of the chloroacetic acid modified epoxy resin precursor is shown as a formula (I) or a formula (II). The invention also discloses a marine antifouling coating, the marine antifouling coating is obtained by carrying out gradient curing reaction on the chloroacetic acid modified epoxy resin precursor and E51 epoxy resin under the action of a curing agent, and the prepared marine antifouling coating structurally contains betaine ester groups and pyrrolidone structures. The marine antifouling paint with the pyrrolidone structure can be subjected to ring opening in a seawater (pH = 8.2) environment, and hydrolysis of ester bonds is promoted by improving hydrophilicity and influencing near ester bond electron cloud density, so that the marine antifouling paint has seawater degradability. In addition, ester bonds in betaine ester groups can also be hydrolyzed in seawater. Secondly, the betaine ester group has the non-specific bactericidal activity of quaternary ammonium salt. The formula (I) and the formula (II) are shown in the description.

The invention discloses a corneal contact lens with a self-healing function and a preparation method of the corneal contact lens, and belongs to the technical field of macromolecules. The preparation method comprises the following steps: dissolving a zwitterionic compound into water or a buffer solution, immersing a corneal contact lens into the solution, adding a cross-linking agent and an initiator, uniformly mixing, standing to enable molecules of the zwitterionic compound, the cross-linking agent and the initiator to be fully distributed in a spatial network of the orthokeratology lens, and polymerizing under ultraviolet irradiation to obtain the orthokeratology lens. After unreacted monomers are removed, the corneal contact lens with the self-healing function is obtained; the zwitterionic compound is one or a combination of more than two of N-(2-amino-2-oxoethyl) acrylamide, acrylamide carboxyl betaine and acrylic ester carboxyl betaine. The corneal contact lens prepared by the invention can realize self-repairing of scratches, solves the problems of bacterial hiding, corneal friction injury, frequent replacement and the like caused by surface injury of a traditional corneal contact lens, and greatly reduces the economic burden while ensuring the eye health of a wearer.