321 results about "Zwitterion" patented technology

The invention relates to the technical field of soil remediation, in particular to a biochar-humic acid-calcium alginic acid composite saline-alkali soil modifier and a preparation and application method thereof. The modifier adopts a multi-layer structure design: biochar is pre-adsorbed by calcium chloride, compounded with sodium humate, and then crosslinked with sodium alginate to form a gel to form a composite inner core; secondly, sulfobetaine methacrylate and vinyl phosphonic acid are introduced into a sodium alginate molecular chain through graft polymerization, and modified sodium alginate is obtained to serve as an outer layer coating material; and finally, dipping the composite inner core into the outer layer solution, and carrying out graded recalcification by calcium chloride and short-time treatment by sodium sulfate to obtain a final product. Through the synergistic effect of calcium ion slow release of the inner core and zwitterionic characteristics of the outer layer, efficient replacement and long-term stable regulation and control of soil sodium ions are achieved, the pH value, the conductivity and the alkalization degree of soil are remarkably reduced, the water holding capacity is effectively improved, and the soil conditioner is suitable for sustainable improvement of moderate and severe saline-alkali soil.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention discloses zwitterion co-doped CeO2 abrasive particles and a preparation method and application thereof.The preparation method includes the steps that a cerium source and a soluble carbonate precipitator are subjected to an aging reaction to obtain a cerium-based precursor, and the cerium-based precursor, fused salt, metal ions and a fluorinating agent are mixed and then roasted to obtain the zwitterion co-doped CeO2 abrasive particles; the synthesis method is simple, the size is controllable, the particle size distribution is uniform, and the spherical-like zwitterion co-doped CeO2 abrasive particles are obtained; the co-doped CeO2 abrasive particles have excellent photo-assisted chemical mechanical polishing performance; when the polishing solution prepared from the sphere-like co-doped CeO2 abrasive particles synthesized by the method is used for processing the surface of quartz glass, the material removal rate reaches 988.69 nm / min, and a high material removal rate is obtained due to the fact that the co-doped CeO2 abrasive particles synthesized by the two-step method shorten the forbidden bandwidth and have high chemical activity, so that the material removal rate is favorably improved.

The invention provides a high slump loss resistant aliphatic water reducer with a branched structure and a controllable polymerization preparation method of the high slump loss resistant aliphatic water reducer. The water reducing agent is prepared from the following components in parts by weight: 14 to 24 parts of acetone, 19 to 29 parts of formaldehyde, 7.5 to 11.5 parts of sodium hydrogen sulfite, 3.5 to 6.5 parts of four-arm star-shaped low-carbon hydrophobic core, 2.5 to 5.5 parts of amide-ester bifunctional slow-release monomer, 2.0 to 4.5 parts of zwitter-ion-phosphonic acid based clay inhibitor and 60 to 90 parts of deionized water. The obtained water reducing agent has good initial dispersibility, stable adsorbability, excellent slump loss resistance and relatively strong clay interference resistance.

The invention belongs to the technical field of electrochemical detection, and discloses an anti-pollution electrochemical saliva sensor based on fluorinated side chain polypeptide as well as a preparation method and application of the anti-pollution electrochemical saliva sensor. The fluorinated side chain polypeptide disclosed by the invention not only has excellent hydrophilicity, can form a dense hydration layer with water molecules to repel pollutants, but also has low surface energy, and the interaction between the pollutants and an interface is remarkably reduced. Through the synergistic effect, the fluorinated side chain polypeptide has better anti-pollution performance compared with traditional zwitterionic polypeptide. The anti-pollution electrochemical sensor constructed on the basis of the fluorinated side chain polypeptide can be used for directly detecting CA15-3 in saliva, the saliva does not need to be pretreated, and the detection accuracy can be comparable with that of a commercial ELISA (Enzyme-Linked Immunosorbent Assay) method.

The invention relates to a preparation method of a water electrolysis hydrogen production composite electrode based on a zwitterionic polymer binder. According to the method, a traditional ionic binder Nafion is replaced with a zwitterionic polymer polysulfobetaine methacrylate, an electrode-electrolyte interface is optimized through a unique electrically neutral hydration layer structure, the rapid desorption behavior of bubbles is enhanced, and efficient transmission of reaction ions is also promoted; and regulating and controlling the mass ratio of the PSBMA binder to the catalyst by using a spraying process. The invention aims to overcome the defects of high cost, insufficient mass transfer and poor interface stability of the existing Nafion binder, and provides the composite electrode taking PSBMA as the binder and the preparation method of the composite electrode, and the provided composite electrode is simple in preparation process and controllable in cost, and has good popularization and application prospects.

The invention relates to the technical field of membrane separation, in particular to a zwitter-ion modified MXene composite membrane as well as a preparation method and application thereof. The method comprises the following steps: S1, preparing a zwitterionic copolymer; s2, blending the zwitterionic copolymer and an MXene nanosheet, so as to obtain an MXene / zwitterionic copolymer dispersion liquid; and S3, preparing the zwitter-ion modified MXene composite membrane on the surface of a porous support layer by using the MXene / zwitter-ion copolymer dispersion liquid through a vacuum filtration method. The zwitter-ion modified MXene composite membrane and the preparation method thereof aim at solving the technical problems that an existing MXene membrane is prone to swelling in water and has defects, so that the separation performance and the pollution resistance are poor, and the obtained zwitter-ion modified MXene composite membrane can inhibit membrane swelling, improve hydrophilicity and pollution resistance and synergistically optimize water flux and selectivity.

The invention relates to the technical field of oil-displacing agents, in particular to a polyacrylamide-containing oil-displacing agent and a preparation method thereof.The polyacrylamide-containing oil-displacing agent is prepared from, by weight, 35-40% of functionalized polyacrylamide, 5-8% of loading filler, 2-3% of n-amyl alcohol, 5-7% of cyclohexane and the balance water; the polyacrylamide is subjected to functional modification, and the loading filler loaded with the zwitterionic surfactant is added, so that the oil-displacing agent can still keep a good synergistic effect in a complex high-temperature and high-salt environment, and a good oil-displacing characteristic is exerted.

The invention discloses a stationary phase of a novel zwitterionic monomer containing a multi-charge structure as well as a preparation method and application of the stationary phase, and belongs to the technical field of hydrophilic interaction chromatography (HILIC) stationary phases. According to the method, multi-charge zwitterions are used as hydrophilic monomers, the multi-charge structure of the multi-charge zwitterions endows the monomers with higher hydrophilic performance, and the multi-charge zwitterions are immobilized on the surface of a matrix by utilizing an active free radical polymerization method, so that a series of novel super-hydrophilic HILIC stationary phases are finally prepared. The multi-charge zwitterionic monomer adopted by the invention not only has better hydrophilic performance and higher charge density, but also can efficiently, simply and conveniently realize matrix surface grafting and modification. The developed stationary phase is suitable for HILIC column chromatography separation analysis, and the HILIC chromatographic performance can be greatly improved; the method can also be applied to the fields of biological sample pretreatment, material science, marker clinical diagnosis and the like, and has high economic and social values.

Surfactant compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous fluid in the presence of a hydroxide base and a neutral surfactant or a reaction product form thereof, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. One or more zwitterionic surfactants may be combined with the surfactant composition in a ratio sufficient to render the resulting combined surfactant composition brine-tolerant, even when both the reaction product and one or more of the zwitterionic surfactant(s) are brine-intolerant. The one or more zwitterionic surfactants may be further selected to render the combined surfactant composition non-emulsifying toward oleaginous fluids.

The application discloses an intrinsic antifouling coating composition based on furan dioxime antibacterial cross-linking agent and application. The intrinsic antifouling coating composition comprises an A component and a B component, the A component comprises a zwitterionic modified hydroxyl silicone oil, and the B component comprises a furan dioxime antibacterial cross-linking agent. After forming a coating, the organic silicon segment, the zwitterionic segment and the furan dioxime segment in the intrinsic antifouling coating composition can respectively endow the coating with dynamic antifouling performance, static antifouling performance and sterilization performance, meanwhile, the coating composition realizes intrinsic triple antifouling without any antifouling agent and related fillers, and is suitable for efficient antifouling of the surface of marine equipment.

The application discloses a kind of salt ion exchange membrane for electrodialysis and preparation method thereof, cation exchange membrane is immersed in the buffer containing tannic acid and zwitterion diamine monomer, reaction is carried out at 0~60 ℃ for 0.5~60 h, obtain salt ion exchange membrane for electrodialysis.The application is formed by the Michael addition or Schiff base reaction between tannic acid molecule and zwitterion diamine monomer under weak alkaline condition, uniform, stable tannic acid / diamine zwitterion ultrathin coating is formed on the surface of cation exchange membrane.The application significantly improves Li + / Mg 2+ Selectivity. Preparation process is simple, environmental protection, strong universality, the modified cation exchange membrane prepared by the application has excellent Li + / Mg 2+ Selectivity, and can improve the anti-pollution of membrane, can be used for high magnesium lithium ratio brine electrodialysis method lithium extraction.

Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.

The invention discloses a super-tensile strong-adhesion quasi-dual-network conductive hydrogel as well as a preparation method and application thereof. The super-tensile strong-adhesion quasi-dual-network conductive hydrogel is characterized in that a zwitterionic monomer and a hydrophilic monomer are polymerized to form a first phase domain, a conductive polymer is used as a second phase domain, the second phase domain is semi-interpenetrated in the first phase domain in a coil / micelle state, and meanwhile, a second ionic cross-linked network is formed; and the second ionic cross-linked network accounts for 3.3 to 33.3 wt% of the quasi-dual-network conductive hydrogel network. According to the quasi-dual-network conductive hydrogel provided by the invention, under the condition of no additional conductive filler or high salt, through an ion bridge-hydrogen bond synergetic quasi-dual-network structure, consideration of high water content, super-large stretching and stable electrical response is realized at the same time.

The application discloses a sensor with a bionic olfactory positioning function, comprising a gate electrode, a dielectric layer and an electrode; the dielectric layer is arranged between the gate electrode and the electrode; and the dielectric layer comprises a porous structure zwitterionic polymer film. Through the combination of the high sensitivity of the sensor to dimethyl carbonate (DMC) and the application method, accurate positioning of a DMC leakage position is realized, and meanwhile, the sensor has the characteristics of high sensitivity, durability and excellent intelligent bionic positioning, and overcomes the positioning function that traditional sensors do not have.

The invention discloses a near-infrared absorption zwitter-ion ethylene-linked covalent organic framework photocatalyst as well as a preparation method and application thereof, and the preparation method comprises the following steps: carrying out hydrothermal reaction on a mixture of an N-(3-sulfopropyl)-2, 4, 6-(trimethyl) pyridine monomer, an aldehyde monomer containing a thiophene unit, organic alkali and water to obtain the near-infrared absorption zwitter-ion ethylene-linked covalent organic framework photocatalyst. The zwitterionic ethylene-linked covalent organic framework photocatalyst ZVCOFs with near-infrared absorption is obtained. According to the method, a one-step green hydrothermal method is adopted, water is used as a solvent, pollution to the environment is reduced, traditional tedious freezing-pumping-unfreezing operation is omitted, high-yield COFs are obtained, and the method has the potential of industrial amplification. The ZVCOFs show excellent hydrophilicity due to rich zwitterionic groups and thiophene units, the light absorption range can be expanded to a near-infrared light region, the light absorption band edge reaches up to 852-1230 nm, and the ZVCOFs have excellent hydrogen evolution performance of photocatalytic water decomposition.

This invention discloses an amphoteric petroleum drilling additive and its preparation method. First, furfuryl acrylate, alkenyl sulfonic acid, alkenyl acid, acrylamide, and methacryloyloxyethyltrimethylammonium chloride are polymerized to obtain an amphoteric copolymer. Then, a bismaleimide derivative is added to crosslink with the furan rings on the polymer side chains to obtain the amphoteric polymer. The amphoteric polymer obtained by this invention simultaneously exhibits unique temperature-responsive rheological properties and an anti-polyelectrolyte effect. At low temperatures, it is beneficial for cutter carryover and wellbore purification; at high temperatures, the crosslinked network dissociates, the molecular chains extend, enhancing inhibition and plugging capabilities, and possessing reversible plugging ability, reducing the difficulty of subsequent drilling and unblocking.

Described herein is a zwitterionic polymer-based coating that, when applied to an electrochemical biosensor, is capable of reducing fouling without compromising the current signal while also facilitating probe attachment.

This invention discloses an amphoteric compound or its pharmaceutically acceptable salt, complex and its applications, wherein the amphoteric compound has a general structural formula as shown in formula (I); the amphoteric compound or its pharmaceutically acceptable salt of this invention can be used to prepare lipid nanoparticles for drug delivery, and the lipid nanoparticle delivery system has higher transfection efficiency, better delivery efficiency and better mRNA encapsulation rate compared with commercially available delivery systems.

The invention belongs to the technical field of electrochemistry, and particularly relates to zwitterionic gel electrolyte for a zinc ion battery system. The gel electrolyte is prepared from a precursor solution containing a specific zwitterionic monomer, a zinc salt, a cross-linking agent and an initiator through an in-situ polymerization reaction. The zwitterionic monomer contains a carbon-carbon double bond and a nitrogen-containing cation center, and the mass ratio of the zwitterionic monomer is 20 wt%-90 wt%. The nitrogen-containing cation center on a zwitterionic polymer chain and functional groups such as sulfonic acid group / carboxylic acid group are utilized to construct an ion transmission channel, and the functional groups are anchored on a polymer main chain, so that the activity of free water is effectively limited, and side reaction and dendritic crystal growth on the surface of a zinc negative electrode are remarkably reduced. The gel electrolyte has high ionic conductivity and excellent interface stability, the cycle life of the zinc ion battery is greatly prolonged, and the electrochemical performance of the zinc ion battery is greatly improved.

The present application relates to the field of water treatment membrane separation technology, in particular to a corrosion-resistant and anti-blocking nanofiltration membrane for coal mine wastewater reverse osmosis treatment and a preparation method thereof, which is used to solve the problem that the existing nanofiltration membrane is prone to chemical corrosion and physical blockage, affecting the service life and treatment efficiency of the membrane; polyether sulfone is used as the base material, which has excellent film-forming property, anti-pollution property, chemical stability and corrosion resistance; amino-MXene, manganese-nickel nanowire and ZIF-8 nanoparticles are added, the amino-MXene enhances the Donnan exclusion effect on heavy metal ions, the manganese-nickel nanowire provides a catalytic site for potassium persulfate, the ZIF-8 nanoparticles provide an additional fast transport channel for water molecules, and the permeability and heavy metal removal rate are improved; polyvinyl alcohol and piperazine form hydrogen bonds to form Turing structures, increase the effective membrane area, and improve the water permeability; the zwitterionic polymer is grafted on the surface of the membrane to form a hydration layer with water molecules, prevent the adsorption of pollutants and prevent blockage.

This invention discloses an enzyme- and pH-responsive nucleic acid loading and delivery material and its preparation method. The material can be used for efficient loading and delivery of nucleic acid molecules. The preparation method uses amphiphilic zwitterionic monomers to improve the reverse emulsion polymerization system, enhancing polymerization at the two-phase interface and avoiding the extrusion effect of polymerization in the aqueous core on nucleic acid molecules, thereby improving the loading efficiency of nucleic acid molecules. Further preparation of cross-linking agents MP-CL and CB-CL, which can cleave in response to matrix metalloproteinase II or cathepsin B, endows the nanogel with the ability to respond to charge reversal in the tumor matrix and to release nucleic acid molecules from tumor cells. The acid-sensitive blocks on the amphiphilic monomers give the nanogel lysosomal escape capability. The delivery material can efficiently deliver nucleic acid molecules into cells and exhibits excellent stability and biosafety.

The application belongs to the technical field of drilling, and particularly relates to a water-based drilling fluid fluid loss additive, a preparation method thereof and application. The water-based drilling fluid fluid loss additive comprises the following raw materials in parts by weight: acrylamide 5-25 parts, zwitterionic monomer 1-15 parts, 2-acrylamido-2-methylpropanesulfonic acid 5-25 parts, initiator 0.1-0.5 parts, and deionized water 60-200 parts. The disclosed fluid loss additive is safe and environmentally friendly, has excellent fluid loss reduction performance under high-temperature and high-salt conditions, and can meet the drilling requirements of high-mineralization and water-sensitive formations.

Disclosed are copolymers, comprising a plurality of zwitterionic repeat units, and a plurality of hydrophobic repeat units, wherein the hydrophobic repeat units each independently comprises a cross-linkable moiety; the cross-linked copolymer network, comprising such copolymer; as well as thin film composite membrane comprising such cross-linked copolymer network.

The invention provides an anti-interference coagulant which comprises nano C-A-H seed crystal, lithium-aluminum layered double hydroxide, calcium aluminate powder, zwitterionic slow-release alkali, cyclic borate, hydroxyl carboxylic acid aluminum complex, redispersible latex powder and superfine quartz powder, and through a synergistic mechanism of seed crystal induction, buffer complexation, lithium slow release and carrier dispersion, the anti-interference coagulant is prepared. Under the low doping amount of 0.05-0.3 wt%, rapid condensation and early-stage high strength under the complex conditions of 5-35 DEG C, high humidity, high alkali, high sulfate radical and the like are achieved, and the high-temperature performance of the refractory material is not affected. The invention also provides a preparation method of the coagulant and an application of the coagulant in a calcium aluminate cement combined refractory material.

An object of the present invention is to provide an agent for promoting undifferentiation that dissolves a drug, as DMSO or the like does, but is capable of promoting undifferentiation without inducing cell differentiation when added to a medium. The agent for promoting undifferentiation of the present invention has an aprotic zwitterion represented by the following formula (1)wherein A is an anion selected from the group consisting of SO3−, —COO−, —OP═O(H)O−, —OP═O(CH3)O− and —OP═O(OR3)O−, R1 is an alkyl group having 1 to 8 carbon atoms and optionally containing one or two oxygen atoms in the molecular chain, R2 is an alkylene group having 3 to 5 carbon atoms, and R3 is hydrogen or an alkyl group optionally having a heteroatom in the molecular chain.

The application provides a synergistically enhanced desalination membrane and a preparation method and application thereof, and relates to the field of membrane separation technology. The desalination membrane comprises a porous ultrafiltration base membrane and a functional layer formed on the surface of the porous ultrafiltration base membrane. The functional layer is formed by blending fluorine-containing polyhydroxy monomers, zwitterionic polyhydroxy monomers and polyamine monomers into an aqueous monomer system, and then copolymerizing and cross-linking the aqueous monomer system with an oil phase system containing acyl chloride monomers at an interface. The fluorine-containing monomers construct low-energy nanochannels in the membrane, improving the water molecule transmission efficiency. The zwitterionic monomers form a super-hydrophilic layer, significantly improving the anti-fouling performance of the membrane. The polyamine monomers participate in the cross-linking reaction, enhancing the compactness of the separation layer and effectively reducing the pore size, so as to realize the balance between high flux and high salt rejection rate. The obtained membrane has high flux, high selectivity and excellent anti-fouling performance, and is suitable for seawater desalination, brackish water desalination, saline-alkali water desalination, wastewater treatment and material separation and concentration.

This invention belongs to the field of semi-permeable membrane preparation technology, specifically relating to a method for preparing a nanofiltration membrane. The preparation method includes the following steps: (1) cleaning the support layer for later use; mixing diamine, aminoβ-cyclodextrin derivative, inorganic hybrid agent, zwitterionic compound and water to obtain an aqueous phase for later use; mixing aromatic acyl chloride, co-solvent and organic solvent to obtain an oil phase for later use; (2) sequentially impregnating the support layer in the aqueous phase once, scraping the membrane, impregnating it in the oil phase a second time, and heating and curing it, and finally performing post-treatment to obtain the nanofiltration membrane. This invention introduces aminoβ-cyclodextrin derivative, inorganic hybrid agent and other components into polyamide to prepare a nanofiltration membrane, further improving the water flux and the ability to effectively separate ions of different valence states of the polyamide nanofiltration membrane.