579 results about "Zwitterion" patented technology

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include a skin-penetrating microneedle array for use in measuring analyte, such as in a continuous manner. The microneedle array may include, for example, at least one microneedle comprising a working electrode comprising an analyte-sensing aptamer that selectively and reversibly binds to analyte. The working electrode comprises at least one thiol-based passivation molecule that provides protection of the working electrode from, by way of example, foulants and interferents. For example, a sensor may be configured to generate a signal that is indicative of a concentration of an analyte in a fluid, the sensor comprising a working electrode comprising an electrode material, a biorecognition layer disposed at least partially on the electrode material and comprising a biorecognition element that selectively and reversibly binds to an analyte, and an at least partially desiccated hydrogel disposed on the biorecognition layer. For example, a working electrode may be configured to generate a signal indicative of a concentration of an analyte in a fluid, the working electrode comprising an electrode material, a biorecognition element disposed on the electrode material that selectively binds to the analyte, wherein the biorecognition element is functionalized with a redox-active molecule and is configured to change conformation upon binding the analyte to move the redox-active molecule, closer to, or further from, the electrode material, and a passivation element comprising a zwitterionic peptide disposed on the electrode material.

The invention discloses a desalting membrane as well as a preparation method and application thereof, and relates to the technical field of membrane separation. The desalting membrane comprises a porous ultrafiltration base membrane and a functional layer formed on the surface of the porous ultrafiltration base membrane; the functional layer is formed by copolymerizing and cross-linking a polyamine monomer, a zwitterionic multi-element hydroxyl monomer and an acyl chloride monomer through an interfacial polymerization reaction. The preparation method comprises the following steps: providing the porous ultrafiltration base membrane; coating the surface of the porous ultrafiltration base membrane with an alkaline water-phase solution containing a polyamine monomer and a zwitterionic multi-hydroxyl monomer to form a water-phase solution layer; coating an oil-phase solution containing an acyl chloride monomer on the surface of the water-phase solution layer to form a functional layer; and performing heat treatment. The invention also provides application of the desalination membrane in any one of seawater desalination, brackish water desalination, wastewater treatment and material separation and concentration. According to the invention, zwitter-ion-based multi-hydroxyl monomers are introduced into water-phase monomers to participate in interfacial polymerization, and a super-hydrophilic nano-channel is constructed in a separation layer, so that the water flux and the desalination rate of the membrane are remarkably improved.

The invention is based, at least in part, on the discovery that replacement of a key bond in the near-infrared fluorophore with a carbon-carbon bond conjugation to a targeting ligand results in vastly increased stability as compared to NIR fluorophores without such a bond, while preserving ligand and zwitterionic properties. In at least one aspect, the invention provides an imaging agent dye comprising a charge-balanced imaging agent conjugated to a targeting vector, wherein the targeting vector is a PSMA binding vector, such as dPSMA-617 or KUE, a FAP binding vector, a bombesin receptor binding vector, or a somatostatin receptor binding vector, and the charge-balanced imaging agent is ZW-800-1, ZW-830-1, or ZW-700-1-Forte.

The invention discloses a temperature / CO2 dual-response zwitterionic hydrogel profile control agent, which is prepared by taking a monomer A, a monomer B and a monomer C as raw materials, adding a cross-linking agent and an initiator, and carrying out polymerization reaction in a water medium. The monomer A is selected from any one of acrylamide, acrylic acid and 1-vinyl-2-pyrrolidone; the monomer B is selected from any one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-((2-(methacryloyloxy) ethyl) dimethylamino) propionic acid inner salt; and the monomer C is selected from any one of 2-(dimethylamino) ethyl methacrylate, dimethylamino propyl methacrylamide and polyethyleneimine. The profile control agent has double swelling mechanisms, has outstanding temperature and salt resistance, resists 220000 mg / L of mineralization water, is suitable for high-salt reservoirs, and is good in long-term aging property.

The invention discloses zwitter-ion supramolecular hydrogel based on anion-pi as well as a preparation method and application of the zwitter-ion supramolecular hydrogel. The hydrogel is formed by self-assembly of a zwitterionic copolymer and a p-styrenesulfonic acid copolymer. According to the supramolecular hydrogel disclosed by the invention, the supramolecular hydrogel can be rapidly formed only by simply mechanically mixing the zwitterionic polymer copolymer and the p-styrene sulfonate copolymer solution, and the supramolecular hydrogel is endowed with excellent injectability and self-repairing performance due to the dynamic cross-linking characteristic. The hydrogel is composed of zwitterions with excellent immunocompatibility and poly (p-styrene sulfonate) with heparin-imitating performance, so that the hydrogel has excellent immunocompatibility, can play a role in various in-vivo application scenes, and in addition, the hydrogel can be used for preparing an anti-inflammatory drug. The dynamic cross-linked network based on anion-pi interaction and the heparin-like structure are very beneficial to protein preservation, and have wide application prospects in the fields of protein delivery and cell encapsulation.

The present invention provides a multifunctional silane coupling agent, which is prepared from commercially available 3-aminopropylsilane coupling agent, acryloxy polyetheramine, and one of an alkylating agent, polyether sulfonate, γ-propane sultone or γ-butyrolactone through Michael addition reaction and quaternization reaction. The multifunctional silane coupling agent is a new variety carrying zwitterions, quaternary ammonium cations and polyether chains, enriching the functions and application scope of silane coupling agents. It can endow some modified materials with surface hydrophilicity, conductivity, antibacterial, antifogging, antifouling, biocompatibility, anticoagulant and wet lubrication properties, etc. at the same time.

The invention relates to the technical field of soil remediation, in particular to a biochar-humic acid-calcium alginic acid composite saline-alkali soil modifier and a preparation and application method thereof. The modifier adopts a multi-layer structure design: biochar is pre-adsorbed by calcium chloride, compounded with sodium humate, and then crosslinked with sodium alginate to form a gel to form a composite inner core; secondly, sulfobetaine methacrylate and vinyl phosphonic acid are introduced into a sodium alginate molecular chain through graft polymerization, and modified sodium alginate is obtained to serve as an outer layer coating material; and finally, dipping the composite inner core into the outer layer solution, and carrying out graded recalcification by calcium chloride and short-time treatment by sodium sulfate to obtain a final product. Through the synergistic effect of calcium ion slow release of the inner core and zwitterionic characteristics of the outer layer, efficient replacement and long-term stable regulation and control of soil sodium ions are achieved, the pH value, the conductivity and the alkalization degree of soil are remarkably reduced, the water holding capacity is effectively improved, and the soil conditioner is suitable for sustainable improvement of moderate and severe saline-alkali soil.

The invention discloses a zwitterionic polymer, an electrochemical sensor and a preparation method and application of the zwitterionic polymer, the zwitterionic polymer is a sulfobetaine type zwitterionic polymer and has high hydrophilicity and electric neutrality, and a hydration layer can be formed on the surface of the zwitterionic polymer through the solvation effect, the hydrogen-bond effect and the like of charged functional groups. The surface of the hydration layer can effectively resist non-specific adsorption, has high anti-pollution performance, and has huge application potential in the field of anti-pollution electrochemical sensors. The invention further provides an electrochemical sensor, the anti-fouling layer formed by the zwitterionic polymer on the electrochemical sensor can effectively resist non-specific adsorption, has high anti-fouling performance, and can reduce and eliminate signal interference in actual sample detection, so that sample pretreatment work is reduced, and the detection accuracy is improved. The method has the characteristics of high anti-interference capability, good reproducibility and the like in chloramphenicol detection.

The invention relates to the technical field of reverse osmosis membranes, and particularly discloses an anti-pollution reverse osmosis membrane and a preparation method thereof.The preparation method comprises the steps that organic amine and organic acyl chloride are used for conducting interfacial polymerization reaction on a bottom membrane to prepare a polyamide layer; the photoinitiator containing amino or phenolic hydroxyl reacts with acyl chloride groups left on the polyamide layer after interfacial polymerization, and the photoinitiator is introduced into the surface of the film; pouring a zwitterionic solution on the surface of the membrane at a constant speed, and irradiating under ultraviolet to initiate a polymerization reaction; performing heat treatment on the membrane in a drying oven to obtain the anti-pollution reverse osmosis membrane. The zwitterionic polymer is efficiently grafted on the surface of the membrane by utilizing a photo-initiation free radical polymerization strategy, compared with a traditional grafting method, the operation process is simple, the grafting speed is high (within 5min), the use of an organic solvent is reduced, and the prepared reverse osmosis membrane has excellent anti-pollution performance and huge industrial application potential.

The present invention provides an organic phosphonic acid betaine and a preparation method thereof, specifically an ammonium phosphonic acid betaine containing a glycidyl group. The organic phosphonic acid betaine can be used as a functional monomer for free radical grafting modification of the surface of a polymer material such as polyolefin, or can be mixed with acrylate, acrylonitrile or other olefin monomers for copolymerization to prepare an amphoteric ionomer. The organic phosphonic acid betaine can also be used for ring-opening grafting modification of polymer materials such as starch, cellulose, polyurethane, and polyamide containing amino or hydroxyl groups in their structures. At the same time, the phosphonic acid betaine imparts functional effects such as zwitterionization, hydrophilicity, antibacterial properties, and antifouling properties to the obtained polymer material. The organic phosphonic acid betaine also has high chemical stability in acidic and alkaline water environments.

The invention discloses an antibacterial antifouling composite material, a multilayer structure and application thereof. The antibacterial antifouling composite material is prepared from the following raw materials: matrix resin, antifouling resin and additives which can be selectively used or not used, wherein the antifouling resin is mainly obtained by reacting zwitter-ion modified hydroxyl silicone oil with a furan dioxime antibacterial cross-linking agent. The antibacterial and antifouling composite material provided by the invention has excellent antibacterial and antifouling properties, is easy to prepare, and can be prepared only through melt extrusion; meanwhile, the antifouling resin has good compatibility with matrix resin, so that the influence on the mechanical property of the composite material under the condition of high addition amount is not obvious, the long-acting antifouling property of the composite material can be met, and the antifouling requirements of marine aquaculture facilities, cables, pipeline systems and the like can be well met.

The invention belongs to the field of graphene textile wastewater treatment, and particularly relates to a graphene oxide-based zwitterionic composite filtering film as well as preparation and application thereof. The SBMA is modified to the GO surface through graft polymerization to form a physical intercalation composite structure, so that the hydrophilicity, interlayer spacing and antifouling property of the membrane are remarkably improved. The retention rate of the composite membrane on methylene blue exceeds 99%, the salt separation factor reaches 180.75, and the flux recovery rate (FRR) is kept above 80% after circulation. The membrane preparation process is green and environment-friendly, is suitable for high-efficiency separation of dye and salt in textile wastewater, and has a wide application prospect.

The invention discloses a zwitter-ion modified acrylate dielectric elastomer film and a preparation method thereof. Zwitter-ions can be selected from sulfobetaine methacrylate (SBMA), carboxyl betaine methacrylate (CBMA), sulfobetaine acrylamide (SBAA) and the like. The acrylate monomer can be butyl acrylate (BA), dodecyl acrylate (LA), isoamyl acrylate (EHA) and the like. Zwitterions (special compounds which simultaneously carry equal positive and negative charges on the same molecule and are electrically neutral on the whole) are copolymerized into an acrylate dielectric elastomer through photo-initiated free radical polymerization reaction, zwitterionic clusters uniformly distributed in the dielectric elastomer can construct traps for capturing high-energy electrons, the leakage current of the material is reduced, and the dielectric property of the material is improved. And the intrinsic breakdown field strength of the material is improved. In addition, the mutual attraction effect between dipole ions with positive and negative charges in the structure provides driving force for intrinsic self-repairing. And after being electrically and mechanically damaged, the material can be self-recovered, so that the service life of the material is prolonged.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention discloses zwitterion co-doped CeO2 abrasive particles and a preparation method and application thereof.The preparation method includes the steps that a cerium source and a soluble carbonate precipitator are subjected to an aging reaction to obtain a cerium-based precursor, and the cerium-based precursor, fused salt, metal ions and a fluorinating agent are mixed and then roasted to obtain the zwitterion co-doped CeO2 abrasive particles; the synthesis method is simple, the size is controllable, the particle size distribution is uniform, and the spherical-like zwitterion co-doped CeO2 abrasive particles are obtained; the co-doped CeO2 abrasive particles have excellent photo-assisted chemical mechanical polishing performance; when the polishing solution prepared from the sphere-like co-doped CeO2 abrasive particles synthesized by the method is used for processing the surface of quartz glass, the material removal rate reaches 988.69 nm / min, and a high material removal rate is obtained due to the fact that the co-doped CeO2 abrasive particles synthesized by the two-step method shorten the forbidden bandwidth and have high chemical activity, so that the material removal rate is favorably improved.

The invention provides a high slump loss resistant aliphatic water reducer with a branched structure and a controllable polymerization preparation method of the high slump loss resistant aliphatic water reducer. The water reducing agent is prepared from the following components in parts by weight: 14 to 24 parts of acetone, 19 to 29 parts of formaldehyde, 7.5 to 11.5 parts of sodium hydrogen sulfite, 3.5 to 6.5 parts of four-arm star-shaped low-carbon hydrophobic core, 2.5 to 5.5 parts of amide-ester bifunctional slow-release monomer, 2.0 to 4.5 parts of zwitter-ion-phosphonic acid based clay inhibitor and 60 to 90 parts of deionized water. The obtained water reducing agent has good initial dispersibility, stable adsorbability, excellent slump loss resistance and relatively strong clay interference resistance.

The invention relates to the technical field of ultrafiltration membranes, and particularly discloses a preparation method of a surface decontamination ultrafiltration membrane. The preparation method of the surface decontamination ultrafiltration membrane comprises the following steps: preparing a sulfonated cross-linked base membrane; preparing a grafting solution; preparing a zwitterionic grafted membrane; preparing a prepolymer solution; and immersing the zwitter-ion grafted membrane into the prepolymer solution, carrying out vacuum impregnation, curing, purging with nitrogen, and carrying out vacuum drying to obtain the surface-decontaminating ultrafiltration membrane. According to the invention, balance among pollution resistance, durability and adaptability is realized through cooperation of molecular design and process. Specifically, the operation energy consumption is reduced by improving the hydrophilicity of a sulfonic group of the surface decontamination ultrafiltration membrane, the cleaning frequency is reduced by inhibiting pollutant adsorption through a zwitterionic layer, and the maintenance cost is reduced by the self-repairing characteristic of a dynamic network, so that a more economical and efficient solution is provided for a high-difficulty water treatment scene.

The invention discloses a medical ultrasonic coupling material and a preparation method and application thereof.The preparation method comprises the steps that clay is dissolved in water and stirred until the clay is dissolved, and a clay solution is prepared; adding sodium hyaluronate into the clay solution, and stirring until the sodium hyaluronate is dissolved to prepare a sodium hyaluronate-clay solution mixed solution; adding a zwitterionic monomer and acrylamide into the sodium hyaluronate-clay solution mixed solution, stirring until the zwitterionic monomer and acrylamide are dissolved, adding a photoinitiator and a cross-linking agent into the pre-polymerized solution, stirring until the photoinitiator and the cross-linking agent are dissolved to prepare the pre-polymerized solution, transferring the pre-polymerized solution into a mold, performing illumination to initiate cross-linking, taking out a sample from the mold, and putting the sample into water for balanced swelling to obtain the solid coupling material. After the medical ultrasonic coupling material is used, the medical ultrasonic coupling material has no residue on tissues, does not need to be wiped and removed, is convenient and sanitary, can accept certain tensile and compressive stress, does not collapse or deform, has good mechanical properties, meets clinical use requirements, can be clamped and fixed on an ultrasonic probe, and does not break.

The invention belongs to the technical field of electrochemical detection, and discloses an anti-pollution electrochemical saliva sensor based on fluorinated side chain polypeptide as well as a preparation method and application of the anti-pollution electrochemical saliva sensor. The fluorinated side chain polypeptide disclosed by the invention not only has excellent hydrophilicity, can form a dense hydration layer with water molecules to repel pollutants, but also has low surface energy, and the interaction between the pollutants and an interface is remarkably reduced. Through the synergistic effect, the fluorinated side chain polypeptide has better anti-pollution performance compared with traditional zwitterionic polypeptide. The anti-pollution electrochemical sensor constructed on the basis of the fluorinated side chain polypeptide can be used for directly detecting CA15-3 in saliva, the saliva does not need to be pretreated, and the detection accuracy can be comparable with that of a commercial ELISA (Enzyme-Linked Immunosorbent Assay) method.

The invention relates to a preparation method of a water electrolysis hydrogen production composite electrode based on a zwitterionic polymer binder. According to the method, a traditional ionic binder Nafion is replaced with a zwitterionic polymer polysulfobetaine methacrylate, an electrode-electrolyte interface is optimized through a unique electrically neutral hydration layer structure, the rapid desorption behavior of bubbles is enhanced, and efficient transmission of reaction ions is also promoted; and regulating and controlling the mass ratio of the PSBMA binder to the catalyst by using a spraying process. The invention aims to overcome the defects of high cost, insufficient mass transfer and poor interface stability of the existing Nafion binder, and provides the composite electrode taking PSBMA as the binder and the preparation method of the composite electrode, and the provided composite electrode is simple in preparation process and controllable in cost, and has good popularization and application prospects.

Systems and methods are provided for multiplexed extraction of target minerals from a variety of separate or combined desalination brines and / or wastewater sources. The use of multiple pretreatment, extraction, and posttreatment apparatuses with intelligent, directed flow control can allow for a single system to extract multiple target minerals. Improved extraction methods including zwitterionic simulated moving bed chromatography with target-specific zwitterions can allow for improved extraction efficiency and recovery rates with a dramatically reduced environmental footprint compared to existing methods.

The invention relates to the technical field of membrane separation, in particular to a zwitter-ion modified MXene composite membrane as well as a preparation method and application thereof. The method comprises the following steps: S1, preparing a zwitterionic copolymer; s2, blending the zwitterionic copolymer and an MXene nanosheet, so as to obtain an MXene / zwitterionic copolymer dispersion liquid; and S3, preparing the zwitter-ion modified MXene composite membrane on the surface of a porous support layer by using the MXene / zwitter-ion copolymer dispersion liquid through a vacuum filtration method. The zwitter-ion modified MXene composite membrane and the preparation method thereof aim at solving the technical problems that an existing MXene membrane is prone to swelling in water and has defects, so that the separation performance and the pollution resistance are poor, and the obtained zwitter-ion modified MXene composite membrane can inhibit membrane swelling, improve hydrophilicity and pollution resistance and synergistically optimize water flux and selectivity.

Systems and methods are provided for multiplexed extraction of target minerals from a variety of separate or combined desalination brines and / or wastewater sources. The use of multiple pretreatment, extraction, and posttreatment apparatuses with intelligent, directed flow control can allow for a single system to extract multiple target minerals. Improved extraction methods including zwitterionic simulated moving bed chromatography with target-specific zwitterions can allow for improved extraction efficiency and recovery rates with a dramatically reduced environmental footprint compared to existing methods.

The invention belongs to the technical field of biomedical materials, and particularly relates to a poly-4-methyl-1-pentene (PMP) gas-blood exchange membrane for an extracorporeal membrane oxygenation (ECMO) system, which realizes a long-acting antithrombotic function through a bionic interface construction technology. The invention aims to provide a bionic antithrombotic PMP gas-blood exchange membrane based on zwitter-ion gradient grafting, and through material and process innovation, the following problems existing in a traditional ECMO gas-blood exchange membrane: an antithrombotic coating is easy to fall off, and the long-term effect is insufficient; the risk of blood injury caused by dependence on heparin or anticoagulants; and the surface modification process destroys the membrane pore structure and air permeability.

The present teachings relate to a polymer system including a coacervate or precipitate formed through dipole-charge interactions or dipole-dipole interactions such as between a polyelectrolyte and a polyzwitterion, which form a polyzwitterionic complex. The polymer system can be used to deliver an encapsulated cargo, for example, a therapeutic drug product, which is released when the ambient pH increases.

The invention discloses a zwitter-ion cross-linked graphene oxide nanofiltration membrane and a preparation method thereof. The nanofiltration membrane is prepared by synthesizing a zwitter-ion cross-linking agent, mixing the zwitter-ion cross-linking agent and a graphene oxide nanosheet dispersion liquid, and carrying out ultrasonic treatment, suction filtration and thermal cross-linking. The invention also discloses a preparation method and application of the nanofiltration membrane. The preparation method comprises the following steps: taking a macroporous polymer membrane as a supporting layer, loading a zwitterionic cross-linking agent and graphene oxide on the supporting layer in a vacuum suction filtration manner, and carrying out thermal cross-linking to obtain the zwitterionic cross-linked graphene oxide nanofiltration membrane. The method is simple to operate and ingenious in design, and the obtained membrane has excellent separation performance. Through crosslinking of the zwitterionic cross-linking agent and the graphene oxide nanosheets, the interlayer spacing of the nanofiltration membrane is stabilized, and quaternary amine groups are introduced between the layers, so that the selectivity to monovalent / divalent anions is improved. Due to the hydrophilicity of zwitterions, the permeability of the cross-linked graphene oxide nanofiltration membrane is improved.

The invention relates to a multifunctional scale inhibition and dispersion agent applied to a reverse osmosis system and a preparation method of the multifunctional scale inhibition and dispersion agent. The multifunctional scale inhibition and dispersion agent comprises the following components in parts by mass: 6-9 parts of CS-GLU, 1.5-2.5 parts of ascorbic acid, 3-4.5 parts of polyaspartic acid, 1-2 parts of sodium gluconate, 2-4 parts of polyethylene glycol, 0.005-0.03 part of nano SiO2, 1-3.5 parts of triammonium citrate, 3-6 parts of acetic acid, 0.2-0.5 part of urea, 1-2.5 parts of EDTA-2Na and 65.47-81.295 parts of deionized water. A traditional scale inhibitor only depends on chemical chelation and has no repair and oxidation resistance. According to the product, chemical scale inhibition and physical repair (film formation and nano filling) are cooperated, and the limitation of a single function is broken through; an anti-oxidation system (ascorbic acid + EDTA) is arranged in the product to replace a dangerous reducing agent, so that the service life of the membrane is prolonged; a traditional scale inhibitor is sensitive to high-valence ions such as Fe < 3 + > and Al < 3 + > and is narrow in applicable water quality range. The charge of the product is adapted to zwitterionic characteristics, and deposition pollution of a traditional anionic scale inhibitor is avoided.

The invention relates to the technical field of oil-displacing agents, in particular to a polyacrylamide-containing oil-displacing agent and a preparation method thereof.The polyacrylamide-containing oil-displacing agent is prepared from, by weight, 35-40% of functionalized polyacrylamide, 5-8% of loading filler, 2-3% of n-amyl alcohol, 5-7% of cyclohexane and the balance water; the polyacrylamide is subjected to functional modification, and the loading filler loaded with the zwitterionic surfactant is added, so that the oil-displacing agent can still keep a good synergistic effect in a complex high-temperature and high-salt environment, and a good oil-displacing characteristic is exerted.

The invention discloses a preparation method of a zwitterionic copolymer ultrafiltration membrane. The preparation method of the zwitterionic copolymer ultrafiltration membrane comprises the following steps: preparing a zwitterionic piperidine monomer; preparing a zwitterionic copolymer; and preparing the zwitterionic ultrafiltration membrane. The zwitterionic copolymer is synthesized by carrying out Friedel-Crafts copolycondensation on terphenyl, a piperidine monomer and a zwitterionic piperidine monomer in a specific proportion. The copolymer has high hydrophilicity and can be directly processed into an ultrafiltration membrane. The ultra-filtration membrane prepared by the preparation method disclosed by the invention is of a compact and interconnected spongy porous structure; the amphoteric ion copolymer membrane prepared by the preparation method can efficiently separate pollutants, shows excellent antifouling performance, can be repeatedly used, solves the problems of poor antifouling capability, low filtering efficiency, short service life and the like of the traditional ultrafiltration membrane, paves a way for directly manufacturing the amphoteric ion copolymer membrane, and provides an effective way for promoting the practical application of the high-performance anti-pollution membrane in a water treatment system.

The invention discloses a stationary phase of a novel zwitterionic monomer containing a multi-charge structure as well as a preparation method and application of the stationary phase, and belongs to the technical field of hydrophilic interaction chromatography (HILIC) stationary phases. According to the method, multi-charge zwitterions are used as hydrophilic monomers, the multi-charge structure of the multi-charge zwitterions endows the monomers with higher hydrophilic performance, and the multi-charge zwitterions are immobilized on the surface of a matrix by utilizing an active free radical polymerization method, so that a series of novel super-hydrophilic HILIC stationary phases are finally prepared. The multi-charge zwitterionic monomer adopted by the invention not only has better hydrophilic performance and higher charge density, but also can efficiently, simply and conveniently realize matrix surface grafting and modification. The developed stationary phase is suitable for HILIC column chromatography separation analysis, and the HILIC chromatographic performance can be greatly improved; the method can also be applied to the fields of biological sample pretreatment, material science, marker clinical diagnosis and the like, and has high economic and social values.