735 results about "Zwitterion" patented technology

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include a skin-penetrating microneedle array for use in measuring analyte, such as in a continuous manner. The microneedle array may include, for example, at least one microneedle comprising a working electrode comprising an analyte-sensing aptamer that selectively and reversibly binds to analyte. The working electrode comprises at least one thiol-based passivation molecule that provides protection of the working electrode from, by way of example, foulants and interferents. For example, a sensor may be configured to generate a signal that is indicative of a concentration of an analyte in a fluid, the sensor comprising a working electrode comprising an electrode material, a biorecognition layer disposed at least partially on the electrode material and comprising a biorecognition element that selectively and reversibly binds to an analyte, and an at least partially desiccated hydrogel disposed on the biorecognition layer. For example, a working electrode may be configured to generate a signal indicative of a concentration of an analyte in a fluid, the working electrode comprising an electrode material, a biorecognition element disposed on the electrode material that selectively binds to the analyte, wherein the biorecognition element is functionalized with a redox-active molecule and is configured to change conformation upon binding the analyte to move the redox-active molecule, closer to, or further from, the electrode material, and a passivation element comprising a zwitterionic peptide disposed on the electrode material.

The invention discloses a desalting membrane as well as a preparation method and application thereof, and relates to the technical field of membrane separation. The desalting membrane comprises a porous ultrafiltration base membrane and a functional layer formed on the surface of the porous ultrafiltration base membrane; the functional layer is formed by copolymerizing and cross-linking a polyamine monomer, a zwitterionic multi-element hydroxyl monomer and an acyl chloride monomer through an interfacial polymerization reaction. The preparation method comprises the following steps: providing the porous ultrafiltration base membrane; coating the surface of the porous ultrafiltration base membrane with an alkaline water-phase solution containing a polyamine monomer and a zwitterionic multi-hydroxyl monomer to form a water-phase solution layer; coating an oil-phase solution containing an acyl chloride monomer on the surface of the water-phase solution layer to form a functional layer; and performing heat treatment. The invention also provides application of the desalination membrane in any one of seawater desalination, brackish water desalination, wastewater treatment and material separation and concentration. According to the invention, zwitter-ion-based multi-hydroxyl monomers are introduced into water-phase monomers to participate in interfacial polymerization, and a super-hydrophilic nano-channel is constructed in a separation layer, so that the water flux and the desalination rate of the membrane are remarkably improved.

The invention is based, at least in part, on the discovery that replacement of a key bond in the near-infrared fluorophore with a carbon-carbon bond conjugation to a targeting ligand results in vastly increased stability as compared to NIR fluorophores without such a bond, while preserving ligand and zwitterionic properties. In at least one aspect, the invention provides an imaging agent dye comprising a charge-balanced imaging agent conjugated to a targeting vector, wherein the targeting vector is a PSMA binding vector, such as dPSMA-617 or KUE, a FAP binding vector, a bombesin receptor binding vector, or a somatostatin receptor binding vector, and the charge-balanced imaging agent is ZW-800-1, ZW-830-1, or ZW-700-1-Forte.

The invention discloses a construction method and application of an electrochemical luminescence (ECL) antifouling sensor based on zwitter-ion hydrogel, and belongs to the technical fields of photoelectric sensing analysis, interface antifouling and environmental science. According to the invention, the hydrogel based on sulfobetaine methacrylate zwitterions and bovine serum albumin is used as the antifouling coating, so that the adsorption of biological proteins and bacteria is effectively hindered, and the service life of the sensor is prolonged. Meanwhile, the interior label Au (at) luminol is packaged in the antifouling hydrogel, so that the integration of interface antifouling and ratio detection is realized, the detection accuracy is improved, and the construction process of the ECL sensor is simplified. The constructed ECL anti-pollution sensor has high sensitivity to chloramphenicol detection, the detection limit is 0.39 pM, and the ECL anti-pollution sensor is suitable for trace detection of antibiotics in seawater.

According to the amido-modified polyanionic cellulose filtrate reducer and the preparation method thereof, amido functional groups are introduced into a molecular structure, and a final product is modified into a zwitterionic type product, so that the temperature resistance of the amido-modified polyanionic cellulose filtrate reducer can be improved, and the temperature resistance of the product can reach 160 DEG C. Besides, due to introduction of amido and a long alkylene oxide chain in the molecular structure, the adsorption capacity and the film-forming lubricating capacity of a modified product can be improved, the filtrate loss reduction performance of the product is remarkably improved, the filtrate loss reduction performance at the normal temperature is improved by at least 30% compared with that of conventional polyanionic cellulose, and the filtrate loss after aging at 160 DEG C is smaller than 13 mL. The amido modified polyanionic cellulose filtrate reducer provided by the invention is good in temperature resistance and obvious in filtrate reduction effect.

The invention discloses a temperature / CO2 dual-response zwitterionic hydrogel profile control agent, which is prepared by taking a monomer A, a monomer B and a monomer C as raw materials, adding a cross-linking agent and an initiator, and carrying out polymerization reaction in a water medium. The monomer A is selected from any one of acrylamide, acrylic acid and 1-vinyl-2-pyrrolidone; the monomer B is selected from any one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-((2-(methacryloyloxy) ethyl) dimethylamino) propionic acid inner salt; and the monomer C is selected from any one of 2-(dimethylamino) ethyl methacrylate, dimethylamino propyl methacrylamide and polyethyleneimine. The profile control agent has double swelling mechanisms, has outstanding temperature and salt resistance, resists 220000 mg / L of mineralization water, is suitable for high-salt reservoirs, and is good in long-term aging property.

The invention discloses zwitter-ion supramolecular hydrogel based on anion-pi as well as a preparation method and application of the zwitter-ion supramolecular hydrogel. The hydrogel is formed by self-assembly of a zwitterionic copolymer and a p-styrenesulfonic acid copolymer. According to the supramolecular hydrogel disclosed by the invention, the supramolecular hydrogel can be rapidly formed only by simply mechanically mixing the zwitterionic polymer copolymer and the p-styrene sulfonate copolymer solution, and the supramolecular hydrogel is endowed with excellent injectability and self-repairing performance due to the dynamic cross-linking characteristic. The hydrogel is composed of zwitterions with excellent immunocompatibility and poly (p-styrene sulfonate) with heparin-imitating performance, so that the hydrogel has excellent immunocompatibility, can play a role in various in-vivo application scenes, and in addition, the hydrogel can be used for preparing an anti-inflammatory drug. The dynamic cross-linked network based on anion-pi interaction and the heparin-like structure are very beneficial to protein preservation, and have wide application prospects in the fields of protein delivery and cell encapsulation.

The invention discloses a construction method and application of a zwitter-ion antifouling and dual-signal-ratio electrochemical biosensor, and belongs to the technical field of biochemical sensing analysis and life science. According to the invention, 3-aminopropyl dimethylamine oxide (APDMAO) zwitterions are prepared to be used as an antifouling interface. Specific positive and negative charges (N < + >-O-) of APDMAO promote hydrogen bond combination with water molecules, and a firm hydration barrier is formed. Meanwhile, the development of APDMAO overcomes the defect that zwitterions are difficult to synthesize and modify, and the application of APDMAO in biosensing analysis is expanded. A methylene blue (MB) internal standard modified alpha fetoprotein (AFP) aptamer is coupled with APDMAO under a controllable potential, so that the detection precision of the sensor is improved. The constructed ratio type electrochemical antifouling biosensor realizes sensitive and accurate detection of AFP, and the detection limit is as low as 3.41 fg / mL.

The present invention provides a multifunctional silane coupling agent, which is prepared from commercially available 3-aminopropylsilane coupling agent, acryloxy polyetheramine, and one of an alkylating agent, polyether sulfonate, γ-propane sultone or γ-butyrolactone through Michael addition reaction and quaternization reaction. The multifunctional silane coupling agent is a new variety carrying zwitterions, quaternary ammonium cations and polyether chains, enriching the functions and application scope of silane coupling agents. It can endow some modified materials with surface hydrophilicity, conductivity, antibacterial, antifogging, antifouling, biocompatibility, anticoagulant and wet lubrication properties, etc. at the same time.

The invention relates to the technical field of oil and gas field development, in particular to a double-network CO2 response type gel particle and application thereof.The first-layer network is formed by covalent bonds between acrylamide, zwitterions and CO2 response monomers (composed of vinylpyridine and DMAEMA) in the gel particle and a cross-linking agent, and the first-layer network is formed by covalent bonds between Ca < 2 + > in mineralized water, pyridine, SO3 <-> in the zwitterionic monomers and coordinated water; coordination bonds exist among Mg < 2 + >, pyridine, carboxyl (acylamino is partially hydrolyzed) and coordinated water, a second-layer network is formed under the synergistic effect of pi-pi bonds among aromatic rings, and the strength of the gel is enhanced through the toughness of the double-network structure. Due to the introduction of an aromatic ring sulphobetaine monomer and water molecules carried by coordinate bonds, the strength of the gel particles in mineralization water is increased, and meanwhile, the gel particles show higher water-retaining property. Due to the introduction of CO2 response monomers with different pKa values, the particles have good CO2 responsiveness, and still have the dual-network structure in mineralized water after response.

The invention discloses an amphoteric self-supporting single-ion polymer electrolyte diaphragm as well as a preparation method and application thereof. The diaphragm is prepared by physically doping a self-supporting single-ion polymer with an amphoteric ionic compound. The polymer electrolyte provided by the invention has a high-molecular polymer structure, negative ions of the polymer electrolyte are relatively fixed in an electrochemical reaction process, and single-ion conduction of lithium ions can be realized, so that uniform deposition of the lithium ions on the surface of a negative electrode is realized, and formation of lithium dendrites is inhibited. Meanwhile, the doped zwitter-ions can increase the dielectric constant of the electrolyte, so that the overall lithium ion conductivity of the electrolyte diaphragm is improved, all the components of the diaphragm are electrolyte components, an additional binder does not need to be added, and the self-supporting electrolyte diaphragm with qualified mechanical properties can be prepared.

The invention relates to the technical field of soil remediation, in particular to a biochar-humic acid-calcium alginic acid composite saline-alkali soil modifier and a preparation and application method thereof. The modifier adopts a multi-layer structure design: biochar is pre-adsorbed by calcium chloride, compounded with sodium humate, and then crosslinked with sodium alginate to form a gel to form a composite inner core; secondly, sulfobetaine methacrylate and vinyl phosphonic acid are introduced into a sodium alginate molecular chain through graft polymerization, and modified sodium alginate is obtained to serve as an outer layer coating material; and finally, dipping the composite inner core into the outer layer solution, and carrying out graded recalcification by calcium chloride and short-time treatment by sodium sulfate to obtain a final product. Through the synergistic effect of calcium ion slow release of the inner core and zwitterionic characteristics of the outer layer, efficient replacement and long-term stable regulation and control of soil sodium ions are achieved, the pH value, the conductivity and the alkalization degree of soil are remarkably reduced, the water holding capacity is effectively improved, and the soil conditioner is suitable for sustainable improvement of moderate and severe saline-alkali soil.

The invention discloses a method for preparing organic carboxylic ester through olefin hydroesterification, and belongs to the technical field of organic carboxylic ester preparation. According to the technical scheme, terminal olefin, CO and alcohol serve as reactants, organic carboxylic ester with one more carbon is generated under the action of an acid auxiliary with zwitterionic liquid serving as a solvent, a phosphine ligand and a catalyst of a Pd compound, the structure of the zwitterionic liquid simultaneously contains an imidazole group and a sulfonate group, and the structural formula of the zwitterionic liquid is shown in the description. The concentration of the zwitterionic liquid in the reaction system is the solvent amount; the molar ratio of the Pd compound to the ionic liquid is (0.1-1): (1000-10000), the molar ratio of the phosphine ligand to the ionic liquid is (0.1-1): (10-100), and the molar ratio of the acid to the ionic liquid is (0.1-1): (2-50). The method has the advantages of mild reaction conditions, wide raw material application range, high reaction activity, good stability and the like, and is a reaction system with a very good industrial application prospect.

The invention discloses a zwitterionic polymer, an electrochemical sensor and a preparation method and application of the zwitterionic polymer, the zwitterionic polymer is a sulfobetaine type zwitterionic polymer and has high hydrophilicity and electric neutrality, and a hydration layer can be formed on the surface of the zwitterionic polymer through the solvation effect, the hydrogen-bond effect and the like of charged functional groups. The surface of the hydration layer can effectively resist non-specific adsorption, has high anti-pollution performance, and has huge application potential in the field of anti-pollution electrochemical sensors. The invention further provides an electrochemical sensor, the anti-fouling layer formed by the zwitterionic polymer on the electrochemical sensor can effectively resist non-specific adsorption, has high anti-fouling performance, and can reduce and eliminate signal interference in actual sample detection, so that sample pretreatment work is reduced, and the detection accuracy is improved. The method has the characteristics of high anti-interference capability, good reproducibility and the like in chloramphenicol detection.

The invention relates to the technical field of reverse osmosis membranes, and particularly discloses an anti-pollution reverse osmosis membrane and a preparation method thereof.The preparation method comprises the steps that organic amine and organic acyl chloride are used for conducting interfacial polymerization reaction on a bottom membrane to prepare a polyamide layer; the photoinitiator containing amino or phenolic hydroxyl reacts with acyl chloride groups left on the polyamide layer after interfacial polymerization, and the photoinitiator is introduced into the surface of the film; pouring a zwitterionic solution on the surface of the membrane at a constant speed, and irradiating under ultraviolet to initiate a polymerization reaction; performing heat treatment on the membrane in a drying oven to obtain the anti-pollution reverse osmosis membrane. The zwitterionic polymer is efficiently grafted on the surface of the membrane by utilizing a photo-initiation free radical polymerization strategy, compared with a traditional grafting method, the operation process is simple, the grafting speed is high (within 5min), the use of an organic solvent is reduced, and the prepared reverse osmosis membrane has excellent anti-pollution performance and huge industrial application potential.

The invention relates to the field of hydrogel preparation, and discloses anti-scale zwitter-ion hydrogel as well as a preparation method and application thereof. The method comprises the following steps: firstly, initiating an oxazine derivative monomer to polymerize through a double-end initiator to generate dihydroxyl polyoxazine; and then, removing a side chain of the polymer to obtain the dihydroxy polypropylene imine. Then, dihydroxy polypropylene imine is selected for further reaction to generate a zwitter-ion precursor polymer, and the zwitter-ion precursor polymer is hydrolyzed to obtain the polypropylene imine zwitter-ion derivative. And finally, converting hydroxyl groups at two ends, synthesizing a zwitterionic macromolecular cross-linking agent, and carrying out polymerization cross-linking in an aqueous solution to prepare the anti-scale zwitterionic hydrogel. The hydrogel is simple in formula, is completely composed of the zwitterionic cross-linking agent, has excellent anti-scaling performance such as protein adsorption resistance, bacterial adsorption resistance and cell adsorption resistance, and is suitable for biological materials, medical devices, implant materials and cell delivery materials.

The present invention provides an organic phosphonic acid betaine and a preparation method thereof, specifically an ammonium phosphonic acid betaine containing a glycidyl group. The organic phosphonic acid betaine can be used as a functional monomer for free radical grafting modification of the surface of a polymer material such as polyolefin, or can be mixed with acrylate, acrylonitrile or other olefin monomers for copolymerization to prepare an amphoteric ionomer. The organic phosphonic acid betaine can also be used for ring-opening grafting modification of polymer materials such as starch, cellulose, polyurethane, and polyamide containing amino or hydroxyl groups in their structures. At the same time, the phosphonic acid betaine imparts functional effects such as zwitterionization, hydrophilicity, antibacterial properties, and antifouling properties to the obtained polymer material. The organic phosphonic acid betaine also has high chemical stability in acidic and alkaline water environments.

The invention discloses an antibacterial antifouling composite material, a multilayer structure and application thereof. The antibacterial antifouling composite material is prepared from the following raw materials: matrix resin, antifouling resin and additives which can be selectively used or not used, wherein the antifouling resin is mainly obtained by reacting zwitter-ion modified hydroxyl silicone oil with a furan dioxime antibacterial cross-linking agent. The antibacterial and antifouling composite material provided by the invention has excellent antibacterial and antifouling properties, is easy to prepare, and can be prepared only through melt extrusion; meanwhile, the antifouling resin has good compatibility with matrix resin, so that the influence on the mechanical property of the composite material under the condition of high addition amount is not obvious, the long-acting antifouling property of the composite material can be met, and the antifouling requirements of marine aquaculture facilities, cables, pipeline systems and the like can be well met.

The invention provides a zwitterionic cross-linking agent, a copolymer flow pattern regulator and a preparation method and application of the zwitterionic cross-linking agent and the copolymer flow pattern regulator. The preparation method comprises the following steps: preparing a polycarboxyl zwitterionic cross-linking agent, and carrying out polymerization reaction on an acrylamide monomer, a sulfonic monomer, alkyl methacrylate and the zwitterionic cross-linking agent to obtain the copolymer flow pattern regulator. The copolymer flow pattern conditioning agent provided by the invention is a hydrophobic cross-linked high-temperature-resistant flow pattern conditioning agent, the temperature resistance can reach 240 DEG C, the NaCl salt resistant concentration is up to 15%, the viscosity retention rate is 80% or above, and the copolymer flow pattern conditioning agent has excellent rheological property after high-temperature aging and has wide application prospects in the field of high-temperature-resistant water-based drilling fluids.

The invention belongs to the field of graphene textile wastewater treatment, and particularly relates to a graphene oxide-based zwitterionic composite filtering film as well as preparation and application thereof. The SBMA is modified to the GO surface through graft polymerization to form a physical intercalation composite structure, so that the hydrophilicity, interlayer spacing and antifouling property of the membrane are remarkably improved. The retention rate of the composite membrane on methylene blue exceeds 99%, the salt separation factor reaches 180.75, and the flux recovery rate (FRR) is kept above 80% after circulation. The membrane preparation process is green and environment-friendly, is suitable for high-efficiency separation of dye and salt in textile wastewater, and has a wide application prospect.

The invention discloses a zwitter-ion modified acrylate dielectric elastomer film and a preparation method thereof. Zwitter-ions can be selected from sulfobetaine methacrylate (SBMA), carboxyl betaine methacrylate (CBMA), sulfobetaine acrylamide (SBAA) and the like. The acrylate monomer can be butyl acrylate (BA), dodecyl acrylate (LA), isoamyl acrylate (EHA) and the like. Zwitterions (special compounds which simultaneously carry equal positive and negative charges on the same molecule and are electrically neutral on the whole) are copolymerized into an acrylate dielectric elastomer through photo-initiated free radical polymerization reaction, zwitterionic clusters uniformly distributed in the dielectric elastomer can construct traps for capturing high-energy electrons, the leakage current of the material is reduced, and the dielectric property of the material is improved. And the intrinsic breakdown field strength of the material is improved. In addition, the mutual attraction effect between dipole ions with positive and negative charges in the structure provides driving force for intrinsic self-repairing. And after being electrically and mechanically damaged, the material can be self-recovered, so that the service life of the material is prolonged.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention belongs to the technical field of olefin hydroesterification reaction and catalysts thereof, and particularly relates to a B-L double-acid ionic liquid and a preparation method thereof, and a method for preparing carboxylic ester by adopting the B-L double-acid ionic liquid as an auxiliary agent and a solvent at the same time. The preparation method of the B-L double-acid type ionic liquid comprises the following steps: mixing a zwitterionic precursor A and a zwitterionic precursor B, and after the reaction is completed, carrying out suction filtration, washing and drying to obtain zwitterionic solid powder; dissolving the zwitterionic solid powder in methanol, dropwise adding acid, and reacting to obtain a B acid type ionic liquid; dropwise adding L acid into the B acid type ionic liquid, stirring for reaction, washing and drying to obtain the B-L double-acid type ionic liquid. The B-L double-acid type ionic liquid provided by the invention is also used as an auxiliary agent and a solvent in the preparation of organic carboxylic ester, the dosage is small, the corrosion to equipment is small, the product is easy to separate, and the B-L double-acid type ionic liquid can be reused and has good catalytic activity.

The invention discloses zwitterion co-doped CeO2 abrasive particles and a preparation method and application thereof.The preparation method includes the steps that a cerium source and a soluble carbonate precipitator are subjected to an aging reaction to obtain a cerium-based precursor, and the cerium-based precursor, fused salt, metal ions and a fluorinating agent are mixed and then roasted to obtain the zwitterion co-doped CeO2 abrasive particles; the synthesis method is simple, the size is controllable, the particle size distribution is uniform, and the spherical-like zwitterion co-doped CeO2 abrasive particles are obtained; the co-doped CeO2 abrasive particles have excellent photo-assisted chemical mechanical polishing performance; when the polishing solution prepared from the sphere-like co-doped CeO2 abrasive particles synthesized by the method is used for processing the surface of quartz glass, the material removal rate reaches 988.69 nm / min, and a high material removal rate is obtained due to the fact that the co-doped CeO2 abrasive particles synthesized by the two-step method shorten the forbidden bandwidth and have high chemical activity, so that the material removal rate is favorably improved.

The invention provides a bionic zwitterionic polymer which comprises a porous polymer base membrane, the surface of the porous polymer base membrane is loaded with polydopamine and a bionic zwitterionic polymer. According to the bionic zwitterionic polymer modified membrane disclosed by the invention, a dopamine monomer and a zwitterionic polymer containing dopamine and amine oxide structural units are utilized to carry out hydrophilic modification on a substrate; wherein the amine oxide zwitterions can form a hydration layer on the surface of the film through hydrogen bonds and electrostatic interaction to serve as a barrier, so that oil molecules are not easily adsorbed on the surface of the film, and the super-hydrophilic and underwater super-oil-transportation net film is prepared; in addition, zwitter-ions are firmly fixed on the surface of a substrate due to super-strong adhesiveness generated by oxidative auto-polymerization of catechol groups in the polydopamine particles and the zwitter-ion copolymer, and the coating prepared by co-deposition is more stable than a coating prepared by single dopamine, has good chemical stability, structural stability and recyclability, and can be applied to the field of chemical engineering. And the service life is longer.

The invention provides a high slump loss resistant aliphatic water reducer with a branched structure and a controllable polymerization preparation method of the high slump loss resistant aliphatic water reducer. The water reducing agent is prepared from the following components in parts by weight: 14 to 24 parts of acetone, 19 to 29 parts of formaldehyde, 7.5 to 11.5 parts of sodium hydrogen sulfite, 3.5 to 6.5 parts of four-arm star-shaped low-carbon hydrophobic core, 2.5 to 5.5 parts of amide-ester bifunctional slow-release monomer, 2.0 to 4.5 parts of zwitter-ion-phosphonic acid based clay inhibitor and 60 to 90 parts of deionized water. The obtained water reducing agent has good initial dispersibility, stable adsorbability, excellent slump loss resistance and relatively strong clay interference resistance.

The invention discloses zwitterionic polymer hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving THMA in water, stirring and dispersing to form THMA suspension; adding AM, SBMA, an initiator and a cross-linking agent into the THMA suspension, and uniformly stirring to prepare a precursor liquid; according to the method, the process is simple, the design is reasonable, the polymer hydrogel with both mechanical performance and conductivity is obtained, the double-attack promotion effect of the hydrogel on promoting wound healing and synchronously monitoring the wound healing condition in real time is achieved, and the application prospect is wide. Wide application prospects are realized.

The invention relates to the technical field of ultrafiltration membranes, and particularly discloses a preparation method of a surface decontamination ultrafiltration membrane. The preparation method of the surface decontamination ultrafiltration membrane comprises the following steps: preparing a sulfonated cross-linked base membrane; preparing a grafting solution; preparing a zwitterionic grafted membrane; preparing a prepolymer solution; and immersing the zwitter-ion grafted membrane into the prepolymer solution, carrying out vacuum impregnation, curing, purging with nitrogen, and carrying out vacuum drying to obtain the surface-decontaminating ultrafiltration membrane. According to the invention, balance among pollution resistance, durability and adaptability is realized through cooperation of molecular design and process. Specifically, the operation energy consumption is reduced by improving the hydrophilicity of a sulfonic group of the surface decontamination ultrafiltration membrane, the cleaning frequency is reduced by inhibiting pollutant adsorption through a zwitterionic layer, and the maintenance cost is reduced by the self-repairing characteristic of a dynamic network, so that a more economical and efficient solution is provided for a high-difficulty water treatment scene.

The invention discloses a medical ultrasonic coupling material and a preparation method and application thereof.The preparation method comprises the steps that clay is dissolved in water and stirred until the clay is dissolved, and a clay solution is prepared; adding sodium hyaluronate into the clay solution, and stirring until the sodium hyaluronate is dissolved to prepare a sodium hyaluronate-clay solution mixed solution; adding a zwitterionic monomer and acrylamide into the sodium hyaluronate-clay solution mixed solution, stirring until the zwitterionic monomer and acrylamide are dissolved, adding a photoinitiator and a cross-linking agent into the pre-polymerized solution, stirring until the photoinitiator and the cross-linking agent are dissolved to prepare the pre-polymerized solution, transferring the pre-polymerized solution into a mold, performing illumination to initiate cross-linking, taking out a sample from the mold, and putting the sample into water for balanced swelling to obtain the solid coupling material. After the medical ultrasonic coupling material is used, the medical ultrasonic coupling material has no residue on tissues, does not need to be wiped and removed, is convenient and sanitary, can accept certain tensile and compressive stress, does not collapse or deform, has good mechanical properties, meets clinical use requirements, can be clamped and fixed on an ultrasonic probe, and does not break.

The invention belongs to the technical field of electrochemical detection, and discloses an anti-pollution electrochemical saliva sensor based on fluorinated side chain polypeptide as well as a preparation method and application of the anti-pollution electrochemical saliva sensor. The fluorinated side chain polypeptide disclosed by the invention not only has excellent hydrophilicity, can form a dense hydration layer with water molecules to repel pollutants, but also has low surface energy, and the interaction between the pollutants and an interface is remarkably reduced. Through the synergistic effect, the fluorinated side chain polypeptide has better anti-pollution performance compared with traditional zwitterionic polypeptide. The anti-pollution electrochemical sensor constructed on the basis of the fluorinated side chain polypeptide can be used for directly detecting CA15-3 in saliva, the saliva does not need to be pretreated, and the detection accuracy can be comparable with that of a commercial ELISA (Enzyme-Linked Immunosorbent Assay) method.