164 results about "Phosphorylcholine" patented technology

The invention belongs to the field of nutrient substance research, and particularly relates to a nutritional composition beneficial to improvement of neural behaviors and cognition. The nutritional composition provided by the invention comprises necessary active ingredients shown in the following (i) and (ii): (i) lactose-N-neotetraose, (ii) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and (iii) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine. The nutritional composition comprises lactose-N-neotetraose and 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine is 1: (0.010-2.0). The lactose-N-neotetraose and the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine can achieve a synergistic effect to improve filial generation repeated engraving behaviors caused by maternal immune activation, decrease of social behavior ability and decrease of anxiety state and memory and recognition ability.

The invention discloses a high-strength self-degradable gel temporary plugging agent and a preparation method thereof, and relates to the technical field of oil-gas field development. The temporary plugging agent is prepared by the following steps: firstly, reacting a diprimary amine compound with unsaturated glycidyl to prepare a multi-arm cross-linking agent, then reacting an acrylamide monomer, an acidic monomer, a rigid monomer and a 2-methacryloyloxyethyl phosphorylcholine monomer under the action of the multi-arm cross-linking agent and an initiator, and after the reaction is finished, crushing, drying and granulating to obtain the temporary plugging agent. The high-strength self-degradation gel temporary plugging agent prepared by the invention not only has relatively high strength, but also can be self-degraded, and the permeability recovery rate of a reservoir after degradation is relatively high, so that the influence on the reservoir is relatively small.

The invention belongs to the technical field of bioengineering, and particularly relates to a phosphorylcholine cytidyltransferase mutant and application thereof. On the basis of phosphorylcholine cytidyltransferase MsCCT001, any one or more of N194D, K91E, G98S, S148A and C156V are mutated respectively, a series of phosphorylcholine cytidyltransferase mutants are obtained through screening, and the obtained mutants have the advantages that in the reaction of catalyzing phosphorylcholine and cytidine triphosphate to generate citicoline, the yield of the obtained mutants is increased, and the yield of the obtained mutants is increased. The catalytic efficiency of the compound is 1.90-2.41 times that of initial phosphorylcholine cytidyltransferase, and a biological enzyme preparation with higher catalytic capacity is provided for preparing citicoline by a biological conversion method.

To provide FVIII drugs with increased in vivo half-life while retaining sufficient biological activity, and prevention methods for hemophilia subjects.SOLUTION: The invention provides a conjugate comprising recombinant FVIII (rFVIII) and a zwitterionic polymer, where the polymer comprises one or more monomer units and where at least one monomer unit comprises a zwitterionic group. Optionally, the zwitterionic group comprises phosphorylcholine. In some conjugates, the polymer is covalently bonded to at least one of an amino group, a hydroxyl group, a sulfhydryl group and a carboxyl group of rFVIII.SELECTED DRAWING: Figure 2

The invention relates to the technical field of medical protection materials, and discloses an anti-allergy skin-friendly operating kit and a preparation technology, and the composite material of the operating kit comprises the following components by mass: 40-70 parts of cellulose-based non-woven fabric; 1 to 10 parts of polymethacryloyloxyethyl phosphorylcholine which is covalently grafted to the cellulose-based non-woven fabric; 20 to 50 parts of polylactic acid-quaternary ammonium salt copolymer; 5 to 15 parts of a polyurethane hot melt adhesive; the method comprises the following steps: grafting a PMPC molecular brush on the surface of a cellulose-based non-woven fabric to obtain a skin-friendly layer; carrying out coaxial electrostatic spinning and solvent treatment on the polylactic acid-quaternary ammonium salt copolymer to prepare a hollow nanofiber barrier layer; and finally hot-pressing and compounding the two layers through a polyurethane hot-melt adhesive. According to the invention, allergy is solved through surface grafting; the toxicity is avoided by using an intrinsic antibacterial polymer; the hollow fibers and the net film are compounded, so that the contradiction between water resistance and breathability is overcome, and the biological safety and comfort of the material are improved.

The invention relates to an endothelialization-promoting antifouling developing coating material as well as a preparation method and application thereof. The endothelialization-promoting antifouling developing coating material is obtained by reacting a siloxane-modified developing agent with a modified phosphorylcholine polymer; the modified phosphorylcholine polymer is obtained by copolymerization of a double-bond-containing monomer, and the double-bond-containing monomer comprises a combination of a double-bond-containing phosphorylcholine monomer, an endothelialization-promoting monomer and a siloxane monomer. According to the endothelialization-promoting antifouling developing coating material disclosed by the invention, a siloxane-modified developing agent is connected with a modified phosphorylcholine polymer. The siloxane-modified developing agent improves the developing function, and the modified phosphorylcholine polymer provides antifouling and endothelialization promoting functions, so that a composite coating with antifouling, developing and endothelialization promoting functions is formed.

Provided is a medical suture thread as a multifilament, which is formed easily bendable and ensuring favorable operability. The medical suture thread 100 includes a core thread 110 and an outer thread 120. The core thread 110 includes multiple twisted ultrafine threads 111, and is arranged at a center portion of the medical suture thread 100. In the ultrafine thread 111, an inner-filament cover layer 112 made of 2-methacryloyloxyethyl phosphorylcholine (MPC) is formed on an outer surface of a filament 111a. The outer thread 120 is formed to be braided with multiple ultrafine threads 121, and covers an outer surface of the core thread 110. In the ultrafine thread 121, an outer-filament cover layer 122 made of MPC is formed on an outer surface of a filament 121a.

The invention discloses an acute kidney injury nuclear magnetic resonance detection contrast agent as well as a preparation method and application thereof. The lipidosome comprises a first lipid component and a second lipid component, the first lipid component is any one of 1, 2-dipalmitoyl-sn-glycerol-3-phosphorylcholine, 1, 2-dioleoyl-sn-glycerol-3-phosphorylcholine and distearoyl phosphatidylcholine, and the second lipid component is a sterol derivative, and the first lipid component is any one of 1, 2-dipalmitoyl-sn-glycerol-3-phosphorylcholine, 1, 2-dioleoyl-sn-glycerol-3-phosphorylcholine and distearoyl phosphatidylcholine. The molar ratio of the first lipid component to the second lipid component is (1-3): 1. According to the invention, all organic free radicals are used for replacing gadolinium ions, so that renal toxicity and systemic fibrosis risks caused by metal accumulation are eliminated, and the method is especially suitable for imaging of patients with renal insufficiency. The material synthesis process is simple, and the cost is controllable. In addition, the system is seamlessly compatible with clinical 3.0 T MRI equipment, additional hardware transformation is not needed, and popularization and application of AKI bedside rapid imaging diagnosis can be directly promoted.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of N-palmitoyl-O-phosphorylcholine serine and a deuterated substance thereof. The N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof are obtained by taking L-serine methyl ester hydrochloride and palmitic acid as raw materials through amidation reaction, phosphate esterification reaction, quaternization reaction, oxidation reaction, reduction reaction and the like. The invention provides an approach for industrial production of the N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof, and is very important for standardization of the detection method of the N-palmitoyl-O-phosphorylcholine serine.

The invention provides 3D printing bio-ink as well as a preparation method and application thereof. The 3D printing bio-ink is prepared from the following components: methacrylic anhydride gelatin, oxidized hyaluronic acid, carboxymethyl chitosan and 2-methacryloyloxyethyl phosphorylcholine. By designing the specific composition of the 3D printing bio-ink, the 3D printing bio-ink which is good in printing performance, mechanical strength and electrical conductivity and high in cell survival rate after printing is prepared, and then a 3D printing stent with high cell-stent interaction is prepared and can be used for preparing a skin injury repair material.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

Provided herein are pharmaceutical compositions and formulations of a conjugate comprising a first protein, such as an anti-VEGF antibody, conjugated to a phosphorylcholine-containing polymer, and a second protein that is not conjugated to a phosphorylcholine-containing polymer. The second protein can be the same as the first protein, or can be different. In some embodiments, the pH of the formulation is different from the isoelectric point (pI) of the second protein so as to prevent or reduce turbidity of the formulation. Also provided are methods of preparing the formulations, methods of use thereof, and kits with pre-filled syringes containing the formulations.

The application belongs to the technical field of medical biomaterials, and particularly relates to an interpenetrating network polymer based on phosphorylcholine polymer and a preparation method and application thereof. The application provides a sequential interpenetrating network method, which comprises the following steps: preparing a monomer infiltration solution containing phosphorylcholine monomer, polyethylene glycol methacrylate, dimethylaminoethyl methacrylate, butyl methacrylate, hydroxyethyl methacrylate, ethylene glycol methacrylate, a crosslinking agent and an initiator; dipping a high-molecular polymer matrix into the monomer infiltration solution, and performing ultrasonic oscillation treatment to promote the infiltration of monomers into the interior of the matrix; and performing a polymerization reaction to obtain a final product after washing; the material prepared by the application has excellent thermal stability, excellent swelling performance, intelligent pH response drug release capacity and biocompatibility, and is suitable for the fields of biological medicine and cosmetics.

Provided are a difluoroalkylphosphorylcholine compound and an intermediate thereof. Specifically provided is a compound represented by formula I or a salt thereof. The compound represented by formula I or a salt thereof exhibits good surface activity, good solubility and good environmental friendliness and biofriendliness, is easy to store at a high concentration and convenient to transport, and has good application prospects.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The invention relates to a magnesium- aluminium layered double hydroxide (Mg-Al LDH) based filler product comprising boron and functionalised with phosphocholine chloride calcium salt tetrahydrate (PC), the synthesis method of this filler product, and obtaining a new material by preparing a composite material of this filler product, which has antibacterial activity, with a thermoplastic polymer or thermosetting polymer. In the production of the composite material that is the subject of the invention, as the polymer, preferably unsaturated polyester resin (DPes) is used. The composite material comprising the filler product of the invention has the feature of preventing bacterial adhesion / biofilm formation. Said material has the potential to be used for various applications, including medical devices, industrial processes, food production, storage and sales areas, food contact surfaces, areas requiring cleaning and hygiene, and different surface materials.

The present invention provides a single-stranded nucleic acid adsorption inhibitor containing one or more polymers selected from the group A: [group A] Polymer A1: a copolymer containing a structural unit (a) derived from 2-(meth) acryloyloxyethyl phosphorylcholine and a structural unit (b) derived from a C2-C6 alkyl (meth) acrylate having two or more hydroxyl groups as substituents; polymer A2: a copolymer containing the constituent unit (a) and a constituent unit (c) derived from a polyethylene glycol (meth) acrylate; and polymer A3: a copolymer containing the constituent unit (a) and a constituent unit (d) derived from a C1-C6 alkyl (meth) acrylate having a phenyl group or a phenoxy group as a substituent.

The invention relates to a ureteral stent with a zwitterionic coating and a preparation method thereof.The ureteral stent comprises a stent body and the zwitterionic coating covering the stent body, the zwitterionic coating is formed by a zwitterionic coating composition, and the zwitterionic coating composition comprises a homopolymer or copolymer of zwitterionic and a solvent; the photocuring layer is covalently bonded on the surface of the bracket in a photocuring manner; the zwitterion is selected from phosphorylcholine; the zwitterionic copolymer is at least formed by copolymerizing a phosphorylcholine monomer and a hydrophilic monomer; or the zwitterionic copolymer is at least formed by copolymerizing the phosphorylcholine monomer, the hydrophilic monomer and the photosensitive monomer. The copolymer / homopolymer of zwitter-ions is covalently fixed on the surface of a base material in a photo-initiation mode, the coating is firm and stable, the coating with hydrophilic lubrication and zwitter-ions simultaneously can be constructed on the surface, the high lubricity function and the high anti-crystallization function are both considered, and the efficient anti-crystallization effect is synergistically achieved.

The present invention provides therapeutic and / or prophylactic treatments against leishmaniasis in non-human mammals in need of such treatment, said treatments comprising administering oleyl phosphocholine to said non-human mammal. The invention also relates to veterinary (pharmaceutical) compositions adapted, suitable and / or intended for use in these treatments.

The invention is applicable to the technical field of electrochemical sensing detection, and provides an electrochemical multi-target joint detection electrode and a preparation method thereof, the joint detection electrode comprises: a substrate, the substrate comprises a glass sheet, an electrode layer and an insulating film which are stacked in sequence; the four working electrodes, the reference electrode and the counter electrode are arranged on the electrode layer; the surface of the working electrode is covalently modified with a phosphorylcholine group and a carboxyl group, the working electrode is prepared into a multi-target electrode capable of joint detection, the detection rate of electrochemical sensing is greatly improved, and the application range of the multi-target electrode is expanded; the working electrode of the combined detection electrode has a large specific surface area, compared with an electrode with a smooth surface, the redox current can be increased, the accessibility of an analyte can be improved, the working electrode has the same surface area, and the consistency of applied working voltage during electrochemical combined detection is effectively guaranteed.

This invention relates to the field of building materials technology, and particularly to a viscosity-reducing polycarboxylate superplasticizer and its preparation method. The viscosity-reducing polycarboxylate superplasticizer uses polyethylene glycol dicyclopentenyl ether methacrylate as the macromonomer, combined with 2-methacryloyloxyethyl phosphocholine, 4-vinylphenylboronic acid, and polyethylene glycol phenyl ether methacrylate as small monomers, prepared via free radical polymerization. Finally, it undergoes freeze-drying and grinding to obtain the target powder product. When the prepared superplasticizer is added to concrete mixtures, it swells and unfolds into a comb-shaped polymer under mechanical stirring and alkaline conditions. Through PEG long side-chain lubrication and steric hindrance, the regulation of surface tension / interfacial energy by phosphocholine groups, and the selective adsorption of borate groups, the initial viscosity is significantly reduced, the viscosity increase over time is controlled, and segregation and bleeding are effectively suppressed, making it suitable for various cementitious systems.

The invention belongs to the technical field of biomedical engineering and optics, and particularly discloses a corneal contact lens antibacterial coating, a preparation method of the corneal contact lens antibacterial coating and a corneal contact lens. The antibacterial coating for the corneal contact lens is prepared from the following raw materials in parts by weight: 20 to 30 parts of phosphorylcholine, 15 to 25 parts of methacryloylethyl betaine, 5 to 8 parts of gallic acid, 3 to 5 parts of dimethylamino styrene, 10 to 15 parts of chitosan quaternary ammonium salt, 0.5 to 3 parts of cross-linking agent and 0.5 to 3 parts of initiator. The antibacterial coating for the corneal contact lens, prepared by the preparation method disclosed by the invention, has good biocompatibility and broad-spectrum antibacterial activity, and is excellent in antibacterial effect; core parameters such as the oxygen permeation amount and the contact angle of the corneal contact lens with the antibacterial coating can be guaranteed.

The invention discloses a liquid composition for a contact lens and a contact lens product. The liquid composition comprises a first hydrophilic component, a second hydrophilic component, inorganic salts and liquid water. The content of the first hydrophilic component is not more than 1 wt%. The first hydrophilic component is a polymer having a phosphorylcholine group, and has a first weight average molecular weight of not less than 4,000 Da, and the second hydrophilic component is a polymer having a phosphorylcholine group. The content of the second hydrophilic component is not more than 1 wt%. The second hydrophilic component is hyaluronic acid or a salt thereof and has a second weight average molecular weight not greater than 10,000 Da.

The invention discloses zwitter-ion-based hydrogel and a preparation method and application thereof.The preparation method includes the steps that zwitter-ion monomers are stirred and dissolved in water under the ice-water bath condition, and a zwitter-ion monomer solution is obtained; injecting the obtained zwitter-ion solution into a mold, and placing in a water bath kettle at 37-60 DEG C for 24-72 hours to obtain zwitter-ion-based hydrogel; wherein the zwitter-ions are selected from at least one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfonic acid propyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-[[2-(methacryloyloxy) ethyl] dimethyl ammonium] propionate. The zwitter-ion hydrogel material provided by the invention has a compression elastic modulus of 22.2-47.8 kPa, which is matched with the elastic modulus of breast tissues, and the hydrogel material has good self-repairing property, and it is found that the compression modulus after compression is equivalent to an initial state value; in addition, the hydrogel also has good tensile property and can bear the action of tensile force.

A blood coagulation time shortening agent for a blood specimen deficient in coagulation factor XII, in activated partial thromboplastin time measurement includes, as an active ingredient, a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit.

The invention belongs to the technical field of organic synthesis, and particularly relates to a polymeric organic base and application of the polymeric organic base in catalytic preparation of a phosphatidylcholine compound. The polymeric organic base disclosed by the invention is a diblock polymer formed by polymerizing a biimidazole guanidine organic tertiary phosphine chain segment and a functional phosphorylcholine chain segment; wherein the biimidazole guanidine organic tertiary phosphine chain segment has strong basicity and can efficiently catalyze the transesterification, and the functionalized phosphorylcholine chain segment is similar to L-alpha-choline alfoscerate in structure and can promote the solubility of organic base and increase the reaction activity at the initial stage of the reaction. The polymeric organic base disclosed by the invention can be used as an immobilized catalyst for preparing phosphatidylcholine compounds from fatty acid ester and L-alpha-choline alfoscerate through transesterification.

The invention discloses a novel serum metabolite composition based on dried blood spot detection and elaborates application of the serum metabolite composition as a marker in preparation of a congenital hypothyroidism diagnostic reagent or kit. The serum metabolite composition comprises thyroxine, 2-piperidone and phosphorylcholine PC (14: 0 / 20: 4). The serum metabolite composition can be used for screening and diagnosing patients with the congenital hypothyroidism, and has the characteristics of low detection cost, good repeatability and relatively high sensitivity and specificity.

The application discloses a high-strength self-degradation gel temporary plugging agent and a preparation method thereof, and relates to the technical field of oil and gas field development. The temporary plugging agent is prepared by the following steps: firstly, a multi-arm crosslinking agent is prepared by reacting a di-primary amine compound with unsaturated glycidol; then, acrylamide monomers, acid monomers, rigid monomers and 2-methacryloyloxyethyl phosphorylcholine monomers are reacted under the action of the multi-arm crosslinking agent and an initiator; and finally, the reaction product is crushed, dried and granulated. The high-strength self-degradation gel temporary plugging agent prepared by the application has high strength, can be self-degraded, and has a high permeability recovery rate of a reservoir after degradation, and has a small influence on the reservoir.

This invention relates to proliposomal powder dispersions of testosterone undecanoate (TU) and phospholipids, including dispersions of TU and palmitoylphosphatidylcholine (DPPC), wherein the weight / weight (w / w) ratio of TU:DPPC in the proliposomal powder dispersion is about 1:2; or TU and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), wherein the weight / weight (w / w) ratio of TU:DMPC in the proliposomal powder dispersion is about 1:3; or TU and a 1-myristoyl-2-palmitoyl-sn-glycero 3-phosphocholine (MPPC), wherein the weight / weight (w / w) ratio of TU:MPPC in the proliposomal powder dispersion is about 1:3.

Provided is a copolymer that can interact with a SiHyCL and mucin. This copolymer includes constituent units of a monomer (a) of formula (1a) or a salt thereof, a monomer (b) of formula (1b) or (2b), and a monomer (c) of formula (1c), the molar ratios thereof being na = 10-70, nb = 25-85, and nc = 5-50, and Mw of the polymer being 10,000-2,000,000. (R1 is H or CH3, X is O or NR2, R2 is H or a C1-4 alkyl group, and n = 1-4). (R3 is H or CH3, Y is O or NR4, R4 is H or a C1-4 alkyl group, and m is 1-6; there may be one or more hydroxyl groups in the carbon chain; A is a phosphorylcholine group or a hydroxyl group, and may be H if m = 1 or if there is a hydroxyl group in the carbon chain). (R5 is H or CH3, and R6 is an alkylene group forming a cyclic structure together with R5 or a C1-4 alkyl group). (R7 is H or CH3, Z is O or NR9, R 9 is H or a C1-4 alkyl group, and R8 is a C1-10 alkyl group).