91 results about "Phosphorylcholine" patented technology

The invention relates to the technical field of medical protection materials, and discloses an anti-allergy skin-friendly operating kit and a preparation technology, and the composite material of the operating kit comprises the following components by mass: 40-70 parts of cellulose-based non-woven fabric; 1 to 10 parts of polymethacryloyloxyethyl phosphorylcholine which is covalently grafted to the cellulose-based non-woven fabric; 20 to 50 parts of polylactic acid-quaternary ammonium salt copolymer; 5 to 15 parts of a polyurethane hot melt adhesive; the method comprises the following steps: grafting a PMPC molecular brush on the surface of a cellulose-based non-woven fabric to obtain a skin-friendly layer; carrying out coaxial electrostatic spinning and solvent treatment on the polylactic acid-quaternary ammonium salt copolymer to prepare a hollow nanofiber barrier layer; and finally hot-pressing and compounding the two layers through a polyurethane hot-melt adhesive. According to the invention, allergy is solved through surface grafting; the toxicity is avoided by using an intrinsic antibacterial polymer; the hollow fibers and the net film are compounded, so that the contradiction between water resistance and breathability is overcome, and the biological safety and comfort of the material are improved.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of N-palmitoyl-O-phosphorylcholine serine and a deuterated substance thereof. The N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof are obtained by taking L-serine methyl ester hydrochloride and palmitic acid as raw materials through amidation reaction, phosphate esterification reaction, quaternization reaction, oxidation reaction, reduction reaction and the like. The invention provides an approach for industrial production of the N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof, and is very important for standardization of the detection method of the N-palmitoyl-O-phosphorylcholine serine.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

The application belongs to the technical field of medical biomaterials, and particularly relates to an interpenetrating network polymer based on phosphorylcholine polymer and a preparation method and application thereof. The application provides a sequential interpenetrating network method, which comprises the following steps: preparing a monomer infiltration solution containing phosphorylcholine monomer, polyethylene glycol methacrylate, dimethylaminoethyl methacrylate, butyl methacrylate, hydroxyethyl methacrylate, ethylene glycol methacrylate, a crosslinking agent and an initiator; dipping a high-molecular polymer matrix into the monomer infiltration solution, and performing ultrasonic oscillation treatment to promote the infiltration of monomers into the interior of the matrix; and performing a polymerization reaction to obtain a final product after washing; the material prepared by the application has excellent thermal stability, excellent swelling performance, intelligent pH response drug release capacity and biocompatibility, and is suitable for the fields of biological medicine and cosmetics.

Provided are a difluoroalkylphosphorylcholine compound and an intermediate thereof. Specifically provided is a compound represented by formula I or a salt thereof. The compound represented by formula I or a salt thereof exhibits good surface activity, good solubility and good environmental friendliness and biofriendliness, is easy to store at a high concentration and convenient to transport, and has good application prospects.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The present invention provides therapeutic and / or prophylactic treatments against leishmaniasis in non-human mammals in need of such treatment, said treatments comprising administering oleyl phosphocholine to said non-human mammal. The invention also relates to veterinary (pharmaceutical) compositions adapted, suitable and / or intended for use in these treatments.

This invention relates to the field of building materials technology, and particularly to a viscosity-reducing polycarboxylate superplasticizer and its preparation method. The viscosity-reducing polycarboxylate superplasticizer uses polyethylene glycol dicyclopentenyl ether methacrylate as the macromonomer, combined with 2-methacryloyloxyethyl phosphocholine, 4-vinylphenylboronic acid, and polyethylene glycol phenyl ether methacrylate as small monomers, prepared via free radical polymerization. Finally, it undergoes freeze-drying and grinding to obtain the target powder product. When the prepared superplasticizer is added to concrete mixtures, it swells and unfolds into a comb-shaped polymer under mechanical stirring and alkaline conditions. Through PEG long side-chain lubrication and steric hindrance, the regulation of surface tension / interfacial energy by phosphocholine groups, and the selective adsorption of borate groups, the initial viscosity is significantly reduced, the viscosity increase over time is controlled, and segregation and bleeding are effectively suppressed, making it suitable for various cementitious systems.

The invention discloses a liquid composition for a contact lens and a contact lens product. The liquid composition comprises a first hydrophilic component, a second hydrophilic component, inorganic salts and liquid water. The content of the first hydrophilic component is not more than 1 wt%. The first hydrophilic component is a polymer having a phosphorylcholine group, and has a first weight average molecular weight of not less than 4,000 Da, and the second hydrophilic component is a polymer having a phosphorylcholine group. The content of the second hydrophilic component is not more than 1 wt%. The second hydrophilic component is hyaluronic acid or a salt thereof and has a second weight average molecular weight not greater than 10,000 Da.

The invention discloses zwitter-ion-based hydrogel and a preparation method and application thereof.The preparation method includes the steps that zwitter-ion monomers are stirred and dissolved in water under the ice-water bath condition, and a zwitter-ion monomer solution is obtained; injecting the obtained zwitter-ion solution into a mold, and placing in a water bath kettle at 37-60 DEG C for 24-72 hours to obtain zwitter-ion-based hydrogel; wherein the zwitter-ions are selected from at least one of [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfonic acid propyl) ammonium hydroxide, 2-methacryloyloxyethyl phosphorylcholine and 3-[[2-(methacryloyloxy) ethyl] dimethyl ammonium] propionate. The zwitter-ion hydrogel material provided by the invention has a compression elastic modulus of 22.2-47.8 kPa, which is matched with the elastic modulus of breast tissues, and the hydrogel material has good self-repairing property, and it is found that the compression modulus after compression is equivalent to an initial state value; in addition, the hydrogel also has good tensile property and can bear the action of tensile force.

A blood coagulation time shortening agent for a blood specimen deficient in coagulation factor XII, in activated partial thromboplastin time measurement includes, as an active ingredient, a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit.

The invention belongs to the technical field of organic synthesis, and particularly relates to a polymeric organic base and application of the polymeric organic base in catalytic preparation of a phosphatidylcholine compound. The polymeric organic base disclosed by the invention is a diblock polymer formed by polymerizing a biimidazole guanidine organic tertiary phosphine chain segment and a functional phosphorylcholine chain segment; wherein the biimidazole guanidine organic tertiary phosphine chain segment has strong basicity and can efficiently catalyze the transesterification, and the functionalized phosphorylcholine chain segment is similar to L-alpha-choline alfoscerate in structure and can promote the solubility of organic base and increase the reaction activity at the initial stage of the reaction. The polymeric organic base disclosed by the invention can be used as an immobilized catalyst for preparing phosphatidylcholine compounds from fatty acid ester and L-alpha-choline alfoscerate through transesterification.

The invention discloses a novel serum metabolite composition based on dried blood spot detection and elaborates application of the serum metabolite composition as a marker in preparation of a congenital hypothyroidism diagnostic reagent or kit. The serum metabolite composition comprises thyroxine, 2-piperidone and phosphorylcholine PC (14: 0 / 20: 4). The serum metabolite composition can be used for screening and diagnosing patients with the congenital hypothyroidism, and has the characteristics of low detection cost, good repeatability and relatively high sensitivity and specificity.

This invention relates to proliposomal powder dispersions of testosterone undecanoate (TU) and phospholipids, including dispersions of TU and palmitoylphosphatidylcholine (DPPC), wherein the weight / weight (w / w) ratio of TU:DPPC in the proliposomal powder dispersion is about 1:2; or TU and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), wherein the weight / weight (w / w) ratio of TU:DMPC in the proliposomal powder dispersion is about 1:3; or TU and a 1-myristoyl-2-palmitoyl-sn-glycero 3-phosphocholine (MPPC), wherein the weight / weight (w / w) ratio of TU:MPPC in the proliposomal powder dispersion is about 1:3.

The invention discloses a rubber composite material with marine antifouling property as well as a preparation method and application thereof, and relates to the technical field of marine fouling organism decay protection materials. The rubber composite material with the marine antifouling property comprises the following components which are blended and vulcanized: rubber, a filler, an antifouling agent, a plasticizer, an activating agent, a scorch retarder, an anti-aging agent, an accelerant and a vulcanizing agent, the antifouling agent comprises a copolymer modified by zwitter-ions and at least one of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione optionally selected from the group consisting of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione. The invention solves the three core problems of poor compatibility of an antifouling agent and a rubber matrix, short antifouling period caused by easy loss of the antifouling agent, and difficulty in balancing the antifouling property and mechanical property in the existing marine antifouling rubber material.

The present invention relates to a silicone-oil-free prefilled syringe and a method for manufacturing same. The silicone-oil-free prefilled syringe of the present invention is in a form coated with an acrylate-based amphoteric material containing a phosphorylcholine group, which is a super-hydrophilic material having excellent biocompatibility, on a rubber gasket of a syringe plunger, and has the advantages of being simply manufactured and overcoming physical and biological problems of existing silicone-oil-coated prefilled syringes.

The invention discloses a saponin liposome immunologic adjuvant and a preparation method thereof, and belongs to the technical field of vaccine adjuvants. The preparation method comprises the following steps: firstly, preparing a blank liposome from 1, 2-dioleoyl-sn-glycerol-3-phosphorylcholine, cholesterol and DSPE-PEG-NHS, and then carrying out surface modification on the liposome by introducing a polyvinyl alcohol-protein graft polymer to form a stable core-shell structure; and finally, encapsulating the QS-21 in the liposome through active drug loading, and freeze-drying to obtain a final product. Through the synergistic effect of the DSPE-PEG-NHS and the polyvinyl alcohol-protein graft polymer, the structural integrity of the liposome in the freeze-drying and storage process is remarkably enhanced, hydrolysis and rearrangement of QS-21 are effectively inhibited, and the problem of chemical instability of QS-21 is solved. The obtained saponin liposome immunologic adjuvant has the advantages of high stability and strong immunogenicity.

Provided herein are pharmaceutical compositions and formulations of a conjugate comprising a first protein, such as an anti-VEGF antibody, conjugated to a phosphorylcholine-containing polymer, and a second protein not conjugated to the phosphorylcholine-containing polymer. The second protein may be the same as the first protein or may be different from the first protein. In some embodiments, the pH of the formulation is different from the isoelectric point (pI) of the second protein to prevent or reduce the turbidity of the formulation. Also provided are methods of making the formulations, methods of use thereof, and kits having pre-filled syringes containing the formulations.

The application discloses a kind of phase change microcapsule-MXene-modified polyacrylate fabric coating and its preparation method and application, belong to fabric coating technical field, including the following steps: MXene dispersion liquid and phosphocholine modified polyacrylate emulsion are mixed, then octadecane polystyrene-polyaniline microcapsule dispersion liquid is added, mixed uniformly, to obtain composite coating slurry;Composite coating slurry is deposited on the surface of fabric using vacuum filtration process, and is dried to obtain phase change microcapsule-MXene-modified polyacrylate fabric coating.The fabric coating preparation method provided by the application is simple and efficient, and the coated fabric is applied in the field of intelligent wearable devices, which can simultaneously realize the multiple responses of conductivity, humidity and thermal management function, and has wide application value.

The invention discloses an anticoagulant polymer-ZIF nano drug delivery system composite material and application, and particularly relates to the technical field of coating materials, the composite material is prepared by fixing an anticoagulant polymer and a ZIF nano drug delivery system through coordination; the anticoagulant polymer is at least one of hydroheparin, thiolated polyethylene glycol, a methacrylic acid phosphorylcholine-based polymer, a methacrylic acid sulphobetaine-based polymer and a methacrylic acid carboxyl betaine-based polymer; and the ZIF nano drug loading system is a ZIF nano carrier modified by a drug. According to the composite material, an organic-inorganic hybrid ZIF loaded medicine which is low in cost and stable in performance is utilized to construct a nano medicine carrying system, so that after the surface of an implanted instrument is coated with the composite material, endothelial cell proliferation can be promoted, active oxygen can be removed, and then the endothelial function is accelerated to be repaired.

The present disclosure provides a Lipid-Phosphocholine-Carboxylic Acid Agent being a compound comprising one or more groups, wherein each group is independently selected from Lipid Moiety (LM), Phosphocholine Moiety (PCM), Carboxylic Acid Moiety, Amide Moiety, and Attachment Moiety (AM), and wherein each group is covalently attached, directly or indirectly, to a multivalent linker (i.e., Composition Linker Moiety (CLM)), or pharmaceutically acceptable salts thereof, and related conjugates. The present disclosure also relates to uses of the Lipid-Phosphocholine-Carboxylic Acid Agents and conjugates, e.g., in delivering nucleic acid and / or treating or preventing diseases.

The application belongs to the technical field of chemical analysis, and particularly relates to a detection method for D-glycophosphocholine content in L-alpha-glycophosphocholine and application. The detection method selects a silica gel surface polysaccharide covalent bonding cellulose type or silica gel surface polysaccharide coating cellulose type normal phase chromatographic column and an evaporative light scattering detector (ELSD), detects through an HPLC-ELSD method, has the advantages of simple operation, high sensitivity, good method specificity and reproducibility, is a high-efficiency liquid phase analysis method convenient for standardized operation, can completely separate L-alpha-glycophosphocholine from low-limit D-glycophosphocholine isomer impurities, and can accurately quantify.

This invention provides a method for synthesizing zwitterionic copolymers, comprising the following steps: a betaine-based zwitterionic monomer and a 2-methacryloyloxyethyl phosphocholine (MPC) monomer are subjected to a free radical copolymerization reaction in a solvent to obtain the zwitterionic copolymer; wherein the betaine-based zwitterionic monomer is selected from carboxybetaine methacrylate (CBMA) monomer or sulfobetaine methacrylate (SBMA) monomer; the free radical copolymerization reaction is selected from reversible addition-fragmentation chain transfer (RAFT) polymerization or free radical polymerization (FRP); when the free radical copolymerization reaction is RAFT polymerization, the copolymerization reaction is carried out in the presence of both an initiator and a chain transfer agent (CTA); when the free radical copolymerization reaction is FRP, the copolymerization reaction is carried out in the presence of an initiator without the addition of a chain transfer agent. This invention can be widely applied in fields such as in vitro diagnostic sealing agents, and is a new generation of fully synthetic biomaterial solutions to replace animal-derived sealing agents and traditional PEG coatings.

The invention provides a quick response type nutrient composition for a cognitive load scene. The quick response type nutrient composition is prepared from the following raw materials in parts by weight: 400 to 600 parts of L-alpha-choline alfoscerate, 0.1 to 0.4 part of pyrroloquinoline quinone disodium salt, 4 to 6 parts of blueberry anthocyanin, 4 to 6 parts of gamma-aminobutyric acid, 4 to 6 parts of L-lysine and 4 to 6 parts of L-arginine. The invention further provides a preparation method and application of the quick response type nutrient composition for the cognitive load scene. Through the synergistic effect of the six components, a nerve cell energy metabolism-neurotransmitter balance-oxidation protection three-channel synergistic mechanism is formed, through the multi-target-point synergistic effect, the prepared nutrient composition has the multiple effects of improving the cognitive decline symptom, rapidly relieving cognitive fatigue, improving the thinking agility and reducing the error rate; the method is especially suitable for a high-intensity cognitive load scene. The invention belongs to the technical field of food processing.

The present disclosure provides a Lipid-Phosphocholine-Carboxylic Acid Agent being a compound comprising one or more groups, wherein each group is independently selected from Lipid Moiety (LM), Phosphocholine Moiety (PCM), Carboxylic Acid Moiety, Amide Moiety, and Attachment Moiety (AM), and wherein each group is covalently attached, directly or indirectly, to a multivalent linker (i.e., Composition Linker Moiety (CLM)), or pharmaceutically acceptable salts thereof, and related conjugates. The present disclosure also relates to uses of the Lipid-Phosphocholine-Carboxylic Acid Agents and conjugates, e.g., in delivering nucleic acid and / or treating or preventing diseases.

This disclosure provides polypeptides that specifically bind to phosphocholine (PC). Also provided are pharmaceutical compositions comprising these polypeptides, nucleic acids encoding these polypeptides, expression vectors and host cells for producing these polypeptides, and methods for treating a target using these polypeptides.

The invention discloses a double-fluorine-chain phosphorylcholine compound and an intermediate thereof. The invention provides a compound as shown in a formula I or a salt thereof. The compound as shown in the formula I or the salt thereof provided by the invention has excellent surface activity, good solubility, good environmental and biological friendliness, easiness in storage at high concentration, convenience in transportation and good application prospect.

The invention discloses a preparation method of a hollow fiber membrane, which comprises the following steps of: reacting a monomer C with neopentyl of which the quaternary carbon atom is connected with carboxyl and the primary carbon atom is connected with hydroxyl with a monomer A with a phosphorylcholine branched chain and a monomer B with methylacryloyl in the hollow fiber membrane; the prepared hollow fiber membrane has alkali-resistant and heat-resistant characteristics after being applied to an ultrafiltration device, and can meet the requirement of frequent disinfection of the ultrafiltration device.

The application belongs to the technical field of bioengineering and particularly relates to a phosphocholine cytidylyltransferase mutant and application thereof. On the basis of phosphocholine cytidylyltransferase MsCCT001, any one or several of N194D, K91E, G98S, S148A and C156V are mutated, and a series of phosphocholine cytidylyltransferase mutants are screened. The catalytic efficiency of the obtained mutant in catalyzing the reaction of generating cytidine diphosphate choline from phosphocholine and cytidine triphosphate is 1.90-2.41 times that of the initial phosphocholine cytidylyltransferase, and the mutant provides a biological enzyme preparation with stronger catalytic capacity for preparing cytidine diphosphate choline by biological conversion.

The invention relates to the technical field of medical materials, and particularly discloses a non-absorbable suture with excellent biocompatibility and a preparation method of the non-absorbable suture. The non-absorbent suture provided by the invention comprises a core layer, a transition layer and a surface functional layer, the core layer and the transition layer are interwoven and fixed through electrostatic spinning, and the surface functional layer is fixed on the surface of the transition layer through vapor deposition polymerization; the diameter of the core layer is 20-50 microns, and the porosity of the core layer is less than 5%; the transition layer is made of polyether-ether-ketone of which the mesh aperture is 10-15 microns and the thickness is 5-10 microns; the surface functional layer is a zwitterionic polymer covalently grafted with phosphorylcholine, and the thickness of the zwitterionic polymer is 0.5-1.2 [mu] m; the invention further provides a preparation method of the non-absorbent suture. The non-absorbable suture has the advantages of being good in biocompatibility, good in long-term mechanical stability and the like, and is suitable for medical suture scenes needing lasting support.