583 results about "Phosphorylcholine" patented technology

A packaging system for the storage of an ionic, hydrogel contact lens employs an aqueous packaging solution including a phosphorylcholine polymer. Preferably, the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 8 and is heat sterilized.

The invention discloses an imitation mussel attachment protein and cell membrane structure double-bionic copolymer shown by the structural formula (I), wherein m is an integer from 10 to 1,000, n is an integer from 0 to 500, and x is an integer from 5 to 500; in the m, n and x, the molar percentage of m is 30-90%, the molar percentage of n is 0-50%, and the molar percentage of x is 10-70%; R1, R2 and R3 are H or CH3; R4 is an alkyl with 4-18 carbon atoms; V is a catechol group with 2-300 carbon atoms in chain connection; W is a hydrophilic group with 2-8 carbon atoms in chain connection; and the hydrophilic group is a quaternary ammonium group, phosphorylcholine group, pyridinium, sulfonic acid group, phosphate group, carboxylic acid group or sulfuric acid group. According to the invention, the coating is in firm combination, the copolymer is almost suitable for an establishment method of a surface imitation cellulosa membrane structure of any material, and the surface hydrophilic performance and biocompatibility of artificial organ and related materials, medicine controlled-release systems, separation materials and other materials can be improved.

Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substituted or unsubstituted alkanoyl, (iv) substituted or unsubstituted alkenoyl wherein the double bond is cis, and (v) (ortho or para) carbonyl-substituted aryl; and wherein the subtituent is each an independent group or linked together thereby forming a ring; and wherein X is one or more substituted or unsubstituted group containing one or more O, N, or S atom and wherein the substituent is each an independent group or linked together thereby forming a ring; and wherein the therapeutic agent is an alcohol-containing water-insoluble steroids or another alcohol containing compounds and methods to prepare such compounds.

An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Contact lens wetting solutions for reducing friction between the contact lens and ocular tissues, and maintaining such effect for a long time, are disclosed. The wetting solution is composed only of a particular ratio of a lubricant composed of copolymer (A) obtained by polymerizing a monomer composition comprising 2-(meth)acryloyloxyethyl phosphorylcholine and alkyl(meth)acrylate, a buffer, an inorganic chloride, a preservative, a chelating agent, and water. The copolymer (A) has a weight average molecular weight of 100,000 to 1,000,000, and satisfies the formula 80≦N×R≦240, provided that 4≦N≦18 and 10%≦R≦60%, wherein N stands for the carbon number of the alkyl group in monomer Y constituting copolymer (A), and R stands for a molar fraction of the unit derived from monomer Y with respect to the sum of the units derived from monomers X and Y.

IgG and IgM autoantibody levels against phosphorylcholine in subjects with hypertension (diastolic pressure>95 mmHg) were determined at baseline in order to determine the importance of antibodies for the development of atherosclerosis. The results show that increases in intima-media thickness (IMT) at a follow-up four years after baseline were significantly less prevalent in subjects having high IgM autoantibodies to phosphorylcholine. The presence or absence of IgM autoantibodies against phosphorylcholine is thus related to an increased or decreased risk of developing ischemic cardiovascular diseases. A method to determine IgM antibodies toward phosphorylcholine is proposed in this invention to identify subjects at risk of developing ischemic cardiovascular diseases. Animal experiments show that medium to high levels of IgM antibodies can be detected in plasma after active immunization with a keyhole limpet hemocyanin (KLH)-phosphorylcholine conjugate. A pharmaceutical composition comprising a phosphorylcholine conjugate (active immunization) or a monoclonal antibody with specificity to a phosphorylcholine conjugate (passive immunization) is proposed and the use of these compositions as active or passive immunogens in the treatment or prevention of atherosclerosis.

The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Compressible and concentrated suspensions containing gas-filled microbubbles, uses thereof for delivering gas into a subject in need thereof, and systems for delivering the compressible suspensions. The gas-filled microbubbles each comprise a gas core surrounded by a lipid membrane, which includes (a) one or more lipids, such as 1,2-disteroyl-sn-glycero-3-phosphocholine (DSPC) or dipalmitoylphosphatidylcholine (DPPC), and (b) one or more stabilizing detergents, such as poloxamer 188, Pluronic F108, Pluronic F127, polyoxyethylene (100) stearyl ether, cholesterol, gelatin, polyvinylpyrrolidone (PVP), and sodium deoxycholate (NaDoc).

The invention discloses a method for forming a simulated cell outer layer membrane structure on the surface of cross-linked chitosan. The method comprises the following steps that: firstly, the chitosan is cross-linked by glutaraldehyde; and secondly, the surface of the cross-linked chitosan is grafted with phosphinylideyne choline groups to construct the simulated cell membrane structure, the reaction of the grafted phosphinylideyne choline groups is carried out in an anhydrous non-protonic solvent, the reaction temperature is between 40 and 80 DEG C, and the concentration of phosphorylcholine dichloride is between 0.1 and 20mg/ml. The test results show that for the surface modified by the simulated cell outer layer membrane structure, the capabilities of adsorbing protein and blood platelet are obviously reduced, and the blood compatibility is obviously improved. The modified material with the simulated cell outer layer membrane structure has wide application prospect in fields such as blood purification, body implantation materials, tissue engineering, slow release of medicines, biological sensors, and the like.

The invention discloses a functional polymer containing phosphorylcholine and PEG and a method for forming a biological pollution resistant interface. The polymer is a functional polymer that contains multiple function groups on a side chain and has a controllable proportion; a PEG flexible chain with larger steric hindrance and outer cell membrane phosphorylcholine hydrophilic group interact to achieve good anti-pollution effect; the polymer contains less than 10% of catechol group, and can be strongly combined with surfaces of various polydopamine-mediated base materials to form a stable hydrophilic monomolecular coating, so that the functional modification of material surfaces is implemented. The method for forming coatings is simple; the coatings can exist on the surface of any base material, so that the ability of resisting adhesion and pollution of multiple biological ingredients of the material surface is improved.

The invention discloses a preparation method of a phosphorylcholine bionic coating. The preparation method comprises the following steps of 1, performing free radical polymerization on ethylene monomers containing phosphorylcholine groups and ethylene monomers containing amino groups under the effect of initiators to obtain phosphorylcholine polymers containing amino groups; 2, dissolving the phosphorylcholine polymers containing amino groups into a polar solvent to obtain a polymer solution; then, adding a glutaraldehyde water solution; uniformly mixing the materials to obtain a mixed solution; 3, coating the mixed solution onto the surface of a material to be modified; after drying, putting the material to be modified into distilled water; soaking the materials for 6h to 12h under the condition of the temperature being 40 DEG C to 80 DEG C; after the materials are taken out, obtaining the phosphorylcholine bionic coating on the surface of the material to be modified. The preparation method has the advantages that the method is simple; the conditions are mild; the method is hopeful to become a novel path for regulating and controlling the action of biological materials with biological activity substances such as protein and platelet; important academic significance is realized.

The present disclosure in a broad aspect provides for diazeniumdiolated phosphorylcholine polymers and associated methods for achieving nitric oxide release. The present polymers have superior biocompatibility and are useful for coating or fabricating medical devices such as a vascular stent.

This invention provides the periodic copolymer PCL-PEO-R which was polymerized with poly-epsilon-caprolactone and polyethylene glycol. The polymerization degree of PCL segment is between 10 and 1000, and the corresponding molecular weight is between 1000 and 100000; the polymerization degree of PEO segment is between 10 and 100, and the corresponding molecular weight is between 400 and 5000; the interval group between tertiary amine N and PEO is the alkyl made up of 2-10 carbon atoms, and the selective preference number of carbon atom is 2-4. The other two alkyls on the atom of tertiary amine N may be the same either the different methyl or ethyl. The alkyls which were used to composite phosphorylcholine were made up of the liner chain or the branched chain, and the saturated or the unsaturated alkyls with 1-20 carbon atoms. This invention also provides the preparation of the interpolymer, as well as its application in the preparation of biology medical material.

The invention relates to a monodisperse nano-polymer carrier with biological compatibility and a method for preparation and carrying drug thereof. Firstly, a reversible addition fragmentation chain transfer (RAFT) polymerization method is used for preparing amphiphilic block copolymers with smaller polydispersity index, wherein the hydrophilic segment is methylacryoyloxyethyl phosphorylcholine (MPC) and the hydrophobic segment is n-butyl methacrylate (BMA). Then through the method of solvent evaporation, the amphiphilic block copolymers are used for preparing nano-polymer micelle, drugs are encapsulated in the micelle through physical action, thus obtaining the monodisperse nano-polymer carrier system with good biological compatibility.

Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula:

where L is a linker group and Z is a non-fouling group including, but not limited to, polyethylene glycol (PEG); oligoethylene glycol (OEG); zwitterionic group, such as phosphorycholine, carboxybetaine, and sulfobetaine; groups that are hydrogen bond acceptors but not hydrogen bond donors. The non-fouling amino acids can be incorporated into a bioactive peptide as single amino acid residues, multiples amino acid residues, or as blocks of amino acids. The non-fouling amino acids, or peptides containing one or more non-fouling amino acids, can be applied to surfaces in order to improve biocompatibility, reduce thrombogenesis, and/or reduce fouling by proteins or bacteria present in solution.

The present invention is process of preparing citicoline sodium. The preparation process includes the biotransformation of material including 5'-cytidylate, phosphorylcholine, potassium hydroxide and glucose with yeast as the biocatalyst; extraction and separation with active carbon as the adsorbing carrier, Cl- type ion exchange resin as the separating carrier and re-compounded water-alcohol mixture as the analyzing reagent; and product purification with alcohol solvent as the crystallizing solvent. Compared with available technology, the present invention has the advantages of high product yield and high product purity.

A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II):

wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR²— and —CH₂O— where R² is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

The invention discloses a preparation method of a di-bionic polymer. The preparation method comprises the following steps: I, preparing a phosphorylcholine polymer containing epoxy groups; and II, dissolving the phosphorylcholine polymer containing epoxy groups in a polar solvent to obtain a polymer solution; under protection of nitrogen, heating the polymer solution to 35-70 DEG C; then adding dopamine hydrochloride and an acid-binding agent into the polymer solution; carrying out grafting reaction under the insulating and stirring condition; after reaction, dialyzing the reaction product in a dialyzing bag by using an aqueous hydrochloric acid solution with the pH value of 3-4; and finally, freeze-drying the dialyzed reaction product to obtain the di-bionic polymer. The preparation method disclosed by the invention is simple in method, mild in condition and high in grafting rate of dopamine, the molar ratio of dopamine groups in the prepared di-bionic polymer is greater than 10%, and the di-bionic polymer is strong in adhesive force and hard to fall.