Polycaprolactone-polyethylene glycol block copolymer, and its preparing method and use

Abstract

This invention provides the periodic copolymer PCL-PEO-R which was polymerized with poly-epsilon-caprolactone and polyethylene glycol. The polymerization degree of PCL segment is between 10 and 1000, and the corresponding molecular weight is between 1000 and 100000; the polymerization degree of PEO segment is between 10 and 100, and the corresponding molecular weight is between 400 and 5000; the interval group between tertiary amine N and PEO is the alkyl made up of 2-10 carbon atoms, and the selective preference number of carbon atom is 2-4. The other two alkyls on the atom of tertiary amine N may be the same either the different methyl or ethyl. The alkyls which were used to composite phosphorylcholine were made up of the liner chain or the branched chain, and the saturated or the unsaturated alkyls with 1-20 carbon atoms. This invention also provides the preparation of the interpolymer, as well as its application in the preparation of biology medical material.

Description

1. Technical field [0001] The invention relates to a polycaprolactone-polyethylene glycol block copolymer with a phosphorylcholine end group, a preparation method of the copolymer and its application in the biocompatibility modification of the surface of a polymer material The application belongs to the field of biomedical materials. 2. Background technology [0002] With the rapid development of biomedical engineering technology, a large number of artificial organs and medical devices made of polymer materials have begun to be valued and some have been used clinically, especially in the fields related to the blood circulation system, such as artificial blood vessels and artificial valves. And endovascular stents etc. have gradually been studied and applied in depth, but their effects are often not very satisfactory due to the formation of thrombus. Therefore, finding a material that not only has good mechanical and mechanical properties, processing properties, aging resist...

AI Technical Summary

Problems solved by technology

[0007] Ultimately, at least three steps of chemical reactions are required to chemically graft the surface of polymer materials, and, due to the specificity of each material, the required steps are even more and more tedious.

[0008] Comparing the two methods of modifying the surface of materials, surface coating and chemical grafting, the surface coating method has the advantages of simplicity and speed, but the durability of the material surface modification is insufficient; while the chemical grafting method can achieve durable material surface Modification, but the process is cumbersome and poor in applicability, and almost every material to be modified requires a series of specific chemical reactions to achieve

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