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Preparation method of di-bionic polymer

A technology of polymer and polymer solution, applied in the field of material surface science and biomedical polymer materials, can solve problems such as difficulty in separation and purification, and achieve the effects of broad application prospects, high grafting rate and simple preparation method

Inactive Publication Date: 2015-07-01
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a dual biomimetic polymer with high and controllable dopamine content was synthesized by the active ester monomer approach, the active ester monomer needs to be prepared in an anhydrous environment, and its separation and purification are extremely difficult

Method used

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  • Preparation method of di-bionic polymer
  • Preparation method of di-bionic polymer

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0028] This embodiment includes the following steps:

[0029] Step 1. Weigh 5mmol 2-methacryloyloxyethylphosphorylcholine and 5mmol glycidyl methacrylate, dissolve and mix them with a solvent to obtain a mixed solution of monomers, and mix 0.1mmol azobisisobutyronitrile Dissolved with tetrahydrofuran to obtain the initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 24 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing epoxy groups; the solvent is formed by mixing methanol and tetrahydrofuran at a volume ratio of 7:1; NMR test results show that the molar content of epoxy groups in the polymer is about 57.7%;

...

Embodiment 2

[0033] This embodiment includes the following steps:

[0034] Step 1. Weigh 7 mmol of acryloyloxyethyl phosphorylcholine and 3 mmol of glycidyl acrylate, dissolve and mix them with a solvent to obtain a mixed solution of monomers, and dissolve 0.1 mmol of azobisisobutyronitrile with tetrahydrofuran to obtain an initiator solution, in N 2 Protection, under the condition of stirring at 60°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution and continue the reaction for 24 hours. Dialyze the concentrated reaction solution in the bag; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing epoxy groups; the solvent is composed of methanol and tetrahydrofuran in a volume ratio of 6:1 It is mixed; NMR test results show that the molar content of epoxy groups in the polymer is about 39.2%;

[0035] Step 2, the phosphorylcholine polymer containing epoxy group described in 0.40m...

Embodiment 3

[0038] This embodiment includes the following steps:

[0039] Step 1. Weigh 6 mmol of 2-methacrylamide ethyl phosphorylcholine and 4 mmol of glycidyl acrylate, dissolve and mix them with a solvent to obtain a mixed solution of monomers, and dissolve 0.1 mmol of azobisisobutyronitrile in tetrahydrofuran to obtain Initiator solution, in N 2 Protection, under the condition of stirring at 80°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution and continue the reaction for 12 hours. Bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing epoxy groups; the solvent is formed by mixing methanol and tetrahydrofuran at a volume ratio of 8:1; NMR test results show that the molar content of epoxy groups in the polymer is about 48.1%;

[0040] Step 2, the phosphorylcholine polymer containing epoxy group described in 0.5mmol step 1 is dissolved in 20mL methanol to obta...

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Abstract

The invention discloses a preparation method of a di-bionic polymer. The preparation method comprises the following steps: I, preparing a phosphorylcholine polymer containing epoxy groups; and II, dissolving the phosphorylcholine polymer containing epoxy groups in a polar solvent to obtain a polymer solution; under protection of nitrogen, heating the polymer solution to 35-70 DEG C; then adding dopamine hydrochloride and an acid-binding agent into the polymer solution; carrying out grafting reaction under the insulating and stirring condition; after reaction, dialyzing the reaction product in a dialyzing bag by using an aqueous hydrochloric acid solution with the pH value of 3-4; and finally, freeze-drying the dialyzed reaction product to obtain the di-bionic polymer. The preparation method disclosed by the invention is simple in method, mild in condition and high in grafting rate of dopamine, the molar ratio of dopamine groups in the prepared di-bionic polymer is greater than 10%, and the di-bionic polymer is strong in adhesive force and hard to fall.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a preparation method of a double biomimetic polymer. Background technique [0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface interaction between the material and the organism, and determine whether the b...

Claims

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Application Information

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IPC IPC(8): C08F230/02C08F220/32C08F8/32
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH
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