3125results about How to "Enhanced inhibitory effect" patented technology

The invention belongs to the technical field of medicines, and particularly relates to quinazoline stilbene derivatives as well as a preparation method, a composition and application thereof. The quinazoline stilbene derivative is synthesized by combining quinazoline with pharmacophores such as a styrene skeleton, and the quinazoline stilbene derivative structurally contains functional units such as a quinazoline functional unit and the pharmacophores such as the styrene skeleton, so that the compound is endowed with good anti-tumor activity. Researches show that the quinazoline stilbene derivative has a good anti-tumor effect including KRASG12C mutation non-small cell lung cancer, has the advantage of multi-target action, has an adjusting effect on Src kinase and related downstream signal channels of Statat, mTOR, Akt and PI3k, and is beneficial to reduction of tumor drug resistance. Compared with a complex structure modified compound, the quinazoline stilbene derivative disclosed by the invention is simple in structure and easy to prepare, and has a good application prospect.

The invention relates to the field of antitumor drugs, in particular to a pharmaceutical composition of a KRAS G12C inhibitor and camptothecin and application of the pharmaceutical composition. The camptothecin and the KRAS G12C inhibitor are combined to play a synergistic effect, a DNA damage repair pathway is inhibited, a better inhibition effect is generated on tumor cells containing KRAS G12C mutation, the dosage required for achieving the same anti-tumor effect is greatly reduced, and the medication safety is improved.

The invention relates to the field of medicinal chemistry, in particular to quinoline compounds or pharmaceutically acceptable salts, isomers, solvates, compositions and medical application thereof. Pharmacological tests prove that the quinoline compound disclosed by the invention has a relatively good affinity effect on KRASG12D-cRaf. When the concentration is 10 M, the compound C1, the compound C3, the compound C4, the compound C6, the compound C11, the compound C12, the compound C13, the compound C16, the compound C22 and the compound C23 have a certain inhibition effect on KRASG12D-cRaf. Particularly, the compound C1 and the compound C12 both show a strong inhibition effect on KRASG12D-cRaf.

The invention provides bacillus velezensis NJ157 and application thereof, and relates to the technical field of biological pesticides. The bacillus velezensis NJ157 can resist saline and alkaline, has a good inhibition effect on ralstonia solanacearum, rhizoctonia solanacearum, fusarium moniliforme and phytophthora capsici, and can effectively prevent and treat tomato bacterial wilt, root rot and fruit rot. The bacillus velezensis NJ157 disclosed by the invention also has relatively strong capability of producing protease, cellulase and IAA (Indoleacetic Acid), and has a relatively good growth promoting effect on tomatoes, and a fungicide prepared from the biocontrol bacterium does not cause pollution to the ecological environment in a use process, and is pollution-free. By using the biocontrol bacterium disclosed by the invention, the dosage of other chemical pesticides can be reduced, the prevention and control cost of tomato diseases is reduced, the tomato growth is promoted, and the biocontrol bacterium has a good popularization value.

The invention discloses a VSG-based energy storage converter three-parameter coordinated adaptive control method, which comprises the following steps of: acquiring three-phase voltage and current of a VSG output port and three-phase voltage data of a grid-connected point, and calculating an output power difference, an output power change rate and a power grid angular frequency difference of the VSG; the power instruction is corrected by combining the power instruction and the power grid angular frequency difference, and the adjustment process of the VSG is divided into six stages according to a power fluctuation curve; the rotational inertia, the virtual damping and the virtual inductance are adjusted according to the power difference and the power change rate in the six stages; the virtual inductor is finely adjusted by combining the VSG output power difference and the output power change rate, and smooth transition of the virtual inductor and smooth adjustment of the power are achieved; the value of the virtual inductance is compared with the initial value of the virtual inductance, and the virtual impedance is subjected to initial value regression operation, so that the power equalization and the system stability of the parallel VSG are not influenced. The method has obvious effects on power oscillation suppression and dynamic performance improvement of the energy storage converter system based on the VSG.

The invention relates to bacillus, a biocontrol inoculant prepared from the bacillus and application of the biocontrol inoculant, and belongs to the technical field of biological inoculants. The bacillus provided by the invention is bacillus subtilis and is named as ZZ1, the preservation unit is China General Microbiological Culture Collection Center, the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, the preservation center is numbered as CGMCC No.31374, and the preservation time is July 19, 2024. The bacillus ZZ1 disclosed by the invention has a certain bacteriostatic effect on different pathogenic bacteria regardless of living bacteria, supernate or cell lysis solution. The bacillus ZZ1 is high in living ability and wide in application range of nutrient sources, temperature, humidity and pH value. The compound has no pathogenicity to fruits and vegetables, has good tolerance to broad-spectrum bactericides, and has a great application prospect.

The invention relates to multi-mode signal processing, and provides a signal processing method of a computer system. The method comprises the following steps: acquiring different modal signal data by using a plurality of sensors and performing timestamp synchronization; a depth time sequence alignment network and a multi-layer dynamic time warping algorithm are utilized to ensure signal time consistency; multi-modal signal features are extracted and fused through a multi-stream depth feature extraction network and a cross-modal attention mechanism; the system adopts a dynamic convolution kernel generation and meta-learning technology to carry out adaptive signal processing; noise suppression and signal optimization are carried out by using a multi-mode noise reduction auto-encoder and a generative adversarial network, and parameters are optimized and processed through closed-loop feedback control and reinforcement learning strategies. According to the method, synchronization, fusion, adaptive processing, noise suppression and real-time feedback control of multi-mode signals are realized, and the method has the advantages of high precision, high robustness and real-time performance.

The invention discloses lactobacillus kefiranofaciens IMAU12319 and application thereof, belongs to the technical field of microorganisms, and particularly relates to lactobacillus kefiranofaciens IMAU12319 which is preserved in China General Microbiological Culture Collection Center (CGMCC) on July 8, 2024, the preservation address is No. 3, No.1 yard, West Beichen Road, Chaoyang District, Beijing, and the number is CGMCC No.31224. The lactobacillus kefiranofaciens IMAU12319 has the advantages that the lactobacillus kefiranofaciens IMAU12319 can be used for preparing the lactobacillus kefiranofaciens IMAU12319, and the lactobacillus kefiranofaciens IMAU12319 can be used for preparing the lactobacillus kefiranofaciens IMAU12319; the invention also relates to an application of the lactobacillus kefiranofaciens IMAU12319 in preparation of a probiotic agent capable of resisting gastrointestinal digestion. The strain disclosed by the invention not only shows good gastrointestinal tract endurance capacity, but also shows relatively strong potential in the aspects of intestinal adhesion, oxidation resistance and bacteriostasis, and has a wide application prospect in leavening agent strains.

The invention relates to a composite metabiotic inoculant for promoting vaginal micro-ecological balance and application thereof. Strain in the composite metabiotic inoculant for promoting vaginal micro-ecological balance comprises an inactivated LA88 strain and an inactivated N13 strain. The invention develops a brand-new probiotic intervention strategy for promoting the micro-ecological balance of the vagina, namely, the inactivated lactobacillus acidophilus LA88 strain and the inactivated lactobacillus plantarum N13 strain are compounded to form a brand-new composite metabiotic bacterial agent, and the composite metabiotic bacterial agent has a relatively good proliferation effect on various beneficial bacteria of the vagina, and can be used for preparing the probiotics for promoting the micro-ecological balance of the vagina. The traditional Chinese medicine composition has a strong inhibition effect on various vaginal pathogenic bacteria, and can promote recovery of a healthy microbial community structure.

The invention discloses a method for analyzing mineral trace elements by utilizing a micro-Raman spectrum, which comprises the following steps of: fixing a mineral sample on a rotary sample table of a micro-Raman spectrometer, selecting an area to be detected by combining a micro-imaging technology, collecting a Raman background signal under the pre-illumination of low-power laser, and analyzing the trace elements in the area to be detected according to the Raman background signal. The laser focal length, the spot size and the incident angle are adjusted accordingly, the laser is focused on a target area, under the calibrated laser condition, through a multi-angle excitation micro-area, after an algorithm is applied to optimize signals, reduce impurity interference and integrate multi-angle Raman signals, the characteristic spectrum information of the microelements can be extracted, and the microelements can be accurately detected. High-resolution analysis of sample components is realized, and a three-dimensional distribution model of microelements in a microcell is constructed in combination with microscopic imaging data. The method has the characteristics of non-destructiveness, high resolution and rapid detection, and is suitable for mineral component analysis in the fields of geology, material science and the like.

The invention provides an inertia optimization method for electric heat gas energy transport channel coordination, and relates to the technical field of energy transport channels, and the method comprises the steps: building a fluid flow state and vortex intensity mapping relation model, which is used for predicting the possible vortex conditions under different working conditions; and based on a prediction result, a genetic algorithm is adopted to optimize a sensor arrangement scheme, and the most comprehensive flow state information is obtained by using the least sensors. According to the method, pipeline vibration safety is considered, a vibration monitoring and valve adjustment limiting mechanism is set, in addition, a tradeoff model of energy loss and transportation efficiency is further constructed, an optimal adjustment strategy is solved by applying a multi-objective optimization algorithm, finally, an eddy current suppression effect evaluation model is established, quantitative evaluation and strategy optimization of a control effect are achieved, and the control effect is optimized. Through the comprehensive application of a series of innovative methods, the precise inhibition of the vortex in the fluid transportation process and the remarkable improvement of the transportation efficiency are realized, and meanwhile, the safe operation of a pipeline system is ensured.

The invention discloses a microbial agent for preventing and treating soil-borne diseases of food crops and a preparation method of the microbial agent, and belongs to the technical field of microorganisms. The microbial inoculum comprises three functional strains, namely pseudomonas guayensis, paenibacillus polymyxa and trichoderma koningiopsis, the three strains are mixed in equal proportion and cooperate with one another, so that the microbial inoculum has a remarkable disease-resistant effect, has an antagonistic effect on various diseases of wheat and corn, can be used for preventing and treating wheat root rot, take-all and banded sclerotial blight as well as corn stem rot and banded sclerotial blight, and has a wide application prospect. Particularly, the inhibition effect on the take-all disease of wheat is optimal. Meanwhile, the coating agent and the auxiliaries are used, so that the acting durability and stability of the microbial inoculum are improved. The microbial agent is matched with a conventional base fertilizer for use, use of chemical bactericides is reduced, growth of common pathogenic bacteria of food crops is effectively inhibited, and the yield of the food crops is increased.

The invention relates to the technical field of adaptive filtering, and discloses a deviation compensation constraint adaptive filtering method and system based on error nonlinearity, and the method comprises the steps: constructing an adaptive weight vector and a noise-containing input signal vector according to an adaptive weight and a noise-containing voice signal sampling value when the weight of an adaptive filter is subjected to linear constraint; after the inner product generates an output signal, an estimation error signal is generated, and an error square median is calculated; calculating an error signal variance estimated value and a self-adaptive weight vector power estimated value according to the error square median and the self-adaptive weight vector, and then calculating an input noise variance estimated value; calculating a deviation compensation item according to the adaptive weight vector and the input noise variance estimation value, and updating the adaptive weight vector with the noise-containing input signal vector and the estimation error signal; and calculating the inner product of the updated adaptive weight vector influenced by the low-efficiency input noise and the noise-containing input signal vector to obtain an output signal subjected to input noise deviation compensation.

The invention discloses an optimal control method and system for beer fermentation, and relates to the technical field of beer fermentation, and the method specifically comprises the following steps: obtaining the gas exchange information of each region at the top of a fermentation tank in real time, analyzing the information after obtaining, predicting the obstruction degree of a bubble layer formed in each region at the top of the fermentation tank to oxygen, and determining whether the oxygen is obstructed or not; dividing each area at the top of the fermentation tank into a high-barrier area, a medium-barrier area and a low-barrier area according to the prediction result; on the basis of the division result of each region, constructing a bubble suppression and oxygen regulation mechanism, and respectively carrying out different oxygen supply and bubble dissipation regulation on the high-barrier region, the medium-barrier region and the low-barrier region; and in the process of adjusting each region by a bubble suppression and oxygen adjustment mechanism, acquiring gas exchange feedback information of each region in real time, and analyzing the acquired gas exchange feedback information. The problem that a bubble layer hinders oxygen penetration is solved, the fermentation efficiency is improved, and the beer quality is guaranteed.

The invention relates to a preparation method and application of an inner-rigid outer-soft core-shell structure silicon dioxide blocking agent for marine drilling fluid, and belongs to the field of deepwater oil and gas drilling. N-vinyl-2-pyrrolidone, dimethyl diallyl ammonium chloride, acrylamide and 2-acrylamide-2-methylpropanesulfonic acid are polymerized and grafted on the surface of nano silicon dioxide to form the silicon dioxide blocking agent with a core-shell structure and a rigid inside and a soft outside; by means of rigid plugging of a nano material and deformation filling flexible plugging of a high-molecular polymer, shale micro-nano pores are efficiently plugged with rigid inside and flexible outside, so that the stability of a well wall is maintained, meanwhile, secondary generation of hydrates is effectively inhibited, and the safety and efficiency of deepwater drilling are improved; the plugging agent provided by the invention reduces the demand on a large number of thermodynamic inhibitors, not only saves the cost, but also has the characteristic of environmental protection.

The invention discloses a metal surface defect detection and classification method, system, equipment and medium, and the method comprises the steps: processing images of different defect types through gray normalization, adaptive histogram equalization, a Gabor filter, a maximum entropy algorithm, morphological processing and an improved local binary pattern; carrying out defect position and size calculation on the processed image, and carrying out GUI (Graphical User Interface) measurement page design; the system, the equipment and the medium are used for realizing the metal surface defect detection and classification method. According to the method, the image processing effect is remarkable, the image contrast is improved, the defect boundary identification is enhanced, the accurate segmentation of the image and the detailed optimization of the structure are realized, the image features are accurately extracted, and efficient classification training is supported; the method has the advantages of improving image quality, enhancing defect detection precision and optimizing feature extraction and analysis, and can be widely applied to the field of high-precision image analysis such as metal defect detection, industrial quality control and computer vision.

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention discloses a permanent magnet synchronous motor active disturbance rejection speed control method based on a double-error correction extended state observer, and the method comprises the steps: constructing a double-error correction extended state observer structure combining a speed estimation error and a position estimation error, and outputting a speed ring lumped disturbance observation value to a feedback control law. An optimized observer parameter setting strategy is designed based on the control structure, decoupling configuration of a zero point and a pole point in a disturbance suppression function is achieved, the position of the zero point in the disturbance suppression function is optimized by combining time domain and frequency domain analysis, and the disturbance suppression performance of the system is enhanced. Therefore, the method has the advantages that on the premise that pole assignment of an original closed-loop system is not affected, the dynamic response and steady-state performance of disturbance suppression are enhanced through the additional zero-point movement track, and the degree of freedom of performance adjustment of the linear expansion state observer and the upper limit of disturbance suppression performance are widened.

The invention relates to the technical field of biological control, in particular to bacillus velezensis JNJK-1, a microbial agent and application of the bacillus velezensis JNJK-1 and the microbial agent in edible fungus disease control, the bacillus velezensis JNJK-1 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CMCC No.31075. The novel bacillus velezensis JNJK-1 is screened out for the first time, and the bacillus velezensis can be applied to biological control of edible mushroom diseases and has a broad-spectrum inhibition effect on pathogenic bacteria of edible mushrooms. Meanwhile, the inventor also finds that the bacillus velezensis JNJK-1, curcumin and sodium alginate are compounded into the microbial agent, so that the inhibition effect on the pathogenic bacteria of the edible fungi can be improved, and the microbial activity can be maintained.

The invention provides a novel strain M2108 of a salt-tolerant bacillus, the preservation number of the salt-tolerant bacillus is CGMCC (China General Microbiological Culture Collection Center) No.28283, and the novel strain M2108 of the salt-tolerant bacillus has relatively good salt tolerance and can grow and proliferate in a high-salt environment; the strain can be rapidly and stably colonized in a plant, and is rapid in propagation speed and strong in multiplication capacity in the plant. The new strain M2108 of the salt-tolerant bacillus provided by the invention has a treatment effect and a high control effect on various plant diseases: the control effect on diseases such as tomato root rot, damping-off and damping-off caused by fusarium oxysporum, pythium aphanidermatum and rhizoctonia solani is high, and the average control effect is 91.2% or above. When being used for preventing and treating plant diseases, the salt-tolerant bacillus M2108 is not easy to generate drug resistance, has good drug effect durability, is safe to human and livestock, and does not cause environmental pollution; the salt-tolerant bacillus M2108 microbial agent and the biocontrol agent provided by the invention are simple in preparation method, low in cost and simple and convenient to use. The salt-tolerant bacillus M2108 has a good application prospect in the prevention and control of plant diseases, and lays a foundation for the development of efficient and broad-spectrum biocontrol preparations.

The invention belongs to the technical field of AC motor transmission control, and relates to a permanent magnet synchronous motor dead zone compensation method based on a nonlinear flux observer. Measuring a motor induction current under a natural coordinate system, and obtaining an alpha-beta axis current through conversion; a non-linear flux observer in an alpha-beta coordinate system is used as a position observation model to obtain an actual rotor position estimation value, a rotating speed ring is formed, and sensorless control of the permanent magnet synchronous motor is achieved; constructing a q-axis voltage disturbance observer by measuring the phase voltage output by the inverter; taking the output of the q-axis disturbance observer as the input of a dead time calculation module to obtain a dead time estimation value; and according to the estimated value, calculating and obtaining a dead-zone compensation voltage, and compensating the output phase voltage of the inverter to realize dead-zone compensation. On the basis of a non-linear flux observer, a position-free control closed-loop structure is constructed, and instruction voltage is corrected, so that the influence of inverter dead time on the permanent magnet synchronous motor is reduced, and the position-free control performance is improved.

The invention discloses a milk-derived broad-spectrum antibacterial peptide and application thereof, and relates to the technical field of biology. The amino acid sequence of the antibacterial peptide is as shown in any one of SEQ ID NO.2-6. Five novel antibacterial peptides are obtained by carrying out symmetrical structure design and amino acid mutation on the basis of a template peptide, and tests find that the five novel antibacterial peptides have broad-spectrum antibacterial activity which is obviously higher than that of the template peptide, and basically have no cytotoxicity. Wherein the geometric mean (GM) of the minimum inhibitory concentration can reach 3.60, and the therapeutic index (TI) can reach 71.11. The antibacterial peptide prepared by the invention still keeps good antibacterial activity in physiological salt concentration and protease environment, has certain serum stability, and has higher application value; in addition, the antibacterial peptide has a good inhibition effect on the formation of a bacterial biofilm, and has a synergistic effect with traditional antibiotics.

The invention discloses a serum-free culture system and culture method of NK cells. The invention firstly discloses a serum-free culture system of the NK cells, wherein the serum-free culture system comprises a coating solution, an amplification culture medium, an activation culture medium and autologous plasma; the invention further discloses a culture method for NK cells by using the serum-free culture system. The method for culturing the NK cells by using the serum-free culture system disclosed by the invention reduces the culture cost of the NK cells, can simply, quickly, efficiently and safely obtain a large number of NK cells with high activity, high purity and strong killing ability in vitro, provides a better cell source for clinical application of the NK cells, and promotes further development of an NK cell treatment technology.

The invention belongs to the field of microbial secondary metabolites, and particularly relates to bacillus velezensis as well as metabolites and application thereof. The bacillus velezensis is classified and named as Bacillus velezensis Z-1, and is preserved in the Guangdong Microbial Culture Collection Center, the preservation number is GDMCC 64975, and the preservation date is August 12, 2024. The bacillus velezensis Z-1 provided by the invention has a relatively strong inhibition effect on mango colletotrichum gloeosporioides in vitro, and the bacteriostasis rate of fermentation liquor can reach 73.33%. The prepared Z-1 bacterial liquid is used for soaking mango fruits, the bacterial liquid can effectively prolong the shelf life of the picked mangoes, the storage period can reach 24 days, in addition, the softening rate of the mangoes is obviously reduced, the fruit skin is full, the mangoes are fresh and turquoise, and the sense organ and the storage quality are maintained at a relatively high level. The method provides a certain new theoretical basis for disease control, storage and fresh-keeping of the harvested mangoes.

The invention discloses a surface acoustic wave device, which comprises a substrate, a first dielectric layer, a piezoelectric layer, an interdigital transducer and a second dielectric layer, the first dielectric layer is arranged on the substrate; the piezoelectric layer is arranged on the first dielectric layer; the interdigital transducer is arranged on the surface of the piezoelectric layer, an overlapping area is formed between the two bus bars in the extending direction of the electrode fingers, a gap area is formed between the overlapping area and the bus bars, and the gap area is adjacent to the ends, close to the overlapping area, of the bus bars; the second dielectric layer is located in at least one gap region and covers the piezoelectric layer and the electrode fingers located in the gap region; wherein the propagation speed of the sound waves in the first dielectric layer and the propagation speed of the sound waves in the second dielectric layer are larger than the propagation speed of the sound waves in the piezoelectric layer, and the thickness of the first dielectric layer and the thickness of the second dielectric layer meet the condition that h2 is smaller than or equal to 0.3 h1. The surface acoustic wave device solves the problem that the Q value of the surface acoustic wave device cannot be improved and the high-frequency impure-mode suppression effect near the anti-resonance point cannot be improved in the prior art.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a series of substituted oxadiazole compounds as well as a preparation method and application thereof. Pharmacological tests show that the series of compounds have strong selectivity and inhibition effect on SphK2, and have anti-proliferation effect on cervical cancer cells, prostate cancer cells and colon cancer cells.

The invention discloses a laser-strengthened wear-resistant powder metallurgy valve seat, which relates to the technical field of powder metallurgy, and comprises a middle concave platform, a collecting hopper is arranged at the top of the middle concave platform, a mold charging barrel is arranged in the collecting hopper, and a plurality of round rods are fixedly connected between the inner wall of the collecting hopper and the outer wall of the mold charging barrel; and a detachable collecting frame is arranged at the bottom of the collecting hopper. Through the arranged die pressing mechanism and the pressing vibration mechanism, when the detachable upper die presses raw material powder in the die charging barrel, the die charging barrel can be synchronously driven to vibrate, so that the raw material powder in the die charging barrel is dispersed, and the uniformity and sufficiency of pressing are guaranteed; and meanwhile, under the vibration effect, overflowing raw materials can conveniently and rapidly fall into the collecting hopper from the edge of the top end of the mold charging barrel, and collection of overflowing raw material powder is accelerated.

The invention relates to the field of microorganisms, in particular to penicillium fox CK152 and application thereof. The invention provides a strain of Penicillium faecium CK152, and the preservation number of the Penicillium faecium CK152 is CGMCC (China General Microbiological Culture Collection Center) NO.41452. The Penicillium faecium CK152 can be used for preparing a strain of Penicillium faecium CK152. Experimental verification shows that a liquid culture of the penicillium fox CK152 strain provided by the invention has a remarkable inhibition effect on magnaporthe oryzae, the bacteriostasis rate of the liquid culture can reach 90%, and the inhibition rate of the liquid culture on magnaporthe oryzae spore germination is 100%. Therefore, the invention provides a new strain which has an excellent control effect on the pathogenic fungi, and the new strain has important significance on the control of the pathogenic fungi.

The utility model discloses a radio frequency power amplifier module mounting device based on elastic limit, which comprises a radio frequency module circuit board, the lower end of the radio frequency module circuit board is provided with a supporting bottom plate, the side surface of the supporting bottom plate is provided with a connecting female port, the inner wall of a groove of the connecting female port is provided with a wire harness interface, and the surface of the wire harness interface is provided with a groove. The radio frequency power amplifier module mounting device based on elastic limiting is provided with a positioning clamping block and a supporting air bag, so that when the device works, a wiring harness interface is inserted into a connecting female port, the positioning clamping block is clamped into an opening of the connecting female port for locking, and the stability is improved; during unlocking, a piston column and a limiting sliding block are pushed to conveniently drive a positioning clamping block to loosen the connecting female opening, unlocking convenience is improved, the positioning clamping block pushes the piston column when the connecting female opening and the wire harness connector are installed, air enters a supporting air bag, the supporting air bag can conveniently support and seal the wire harness connector, and therefore sealing performance and stability are improved.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a gentiopicroside amide derivative, a synthesis method and application. A series of gentiopicroside amide derivatives are synthesized by taking gentiopicroside as a research object, carrying out structural modification on 6 '-site hydroxyl of gentiopicroside and introducing a benzoyl chloride group into a gentiopicroside structure. The synthetic method has the beneficial effects that on one hand, the synthetic method of the gentiopicroside amide derivative, which is mild in reaction condition and environment-friendly, is established; on the other hand, the 20 synthesized gentiopicroside amide derivatives have a remarkable inhibition effect on expression of LPS-induced THP-1 macrophage IL-6 and STAT3 protein content, the anti-inflammatory activity is remarkable, the action effect is superior to that of parent compound gentiopicroside, and a new thought is provided for preparation of STAT3 small-molecule inhibitors and anti-inflammatory drugs.