552results about How to "Enhanced inhibitory effect" patented technology

The invention discloses an oligopeptide from undaria pinnatifida and application thereof. The amino acid sequence of the oligopeptide is YRKD, and the molecular weight is 580.63 g / mol. The polypeptide is identified from undaria pinnatifida through a high performance liquid chromatography technology for the first time, and an unreported oligopeptide capable of inhibiting tyrosinase and cooperating with vitamin C to synergistically inhibit tyrosinase is screened out. The oligopeptide derived from undaria pinnatifida is synthesized by a solid phase method, has the characteristics of safety, no toxicity, good water solubility and good stability, and is combined with vitamin C to generate a synergistic effect and synergistically increase the inhibition effect on tyrosinase, so that the oligopeptide can achieve a better tyrosinase inhibition effect at a lower and more stable concentration; the use concentration of the oligopeptide can be greatly reduced, the stability is enhanced, and the oligopeptide can be widely applied to preparation of cosmetics, medicines, health-care products or food additives, and has important economic value and social significance.

The invention discloses a Transform low-light image enhancement method based on dynamic four-priori, and the method comprises the steps: obtaining a low-light image data set, and dividing the low-light image data set into a training sample set, a verification sample set and a test sample set; a Transform low-light image enhancement model DQPGT based on the dynamic four priori is constructed; inputting the training sample set into a DQPGT model to train the model, and verifying the model through the verification sample set to complete training of the DQPGT model; inputting a test sample set into the trained model for image enhancement and then outputting the test sample set; according to the method, spatial and frequency domain feature representation is collaboratively optimized on the basis of dynamic four-priori estimation and a frequency domain channel attention mechanism, so that the problems of uneven exposure, noise amplification and color distortion of an existing method based on the Retinex theory under a complex real illumination condition are solved.

An intelligent control method, equipment and medium based on a flue gas desulfurization process belong to the technical field of dry and semi-dry desulfurization, solve the problem of how to improve the working condition adaptability of dry and semi-dry desulfurization processes, and comprise the following steps: a feedforward prediction step: based on historical operation data, predicting the theoretical addition amount of a desulfurizer through a feedforward prediction model; a feedback correction step: dynamically correcting the theoretical addition amount of the desulfurizing agent based on the real-time SO2 concentration deviation, obtaining the final addition amount of the final desulfurizing agent, executing the final addition amount, and performing secondary correction according to the execution result; a model iteration step: continuously optimizing the feedforward prediction model based on incremental data generated in a system operation process; according to the method, the deviation mode is analyzed by verifying the outlet SO2 concentration data in real time, secondary correction is executed, correction strategies are customized for various complex working conditions, the working condition adaptability of dry-method and semi-dry-method desulfurization processes is effectively improved, and accurate prediction and real-time control of the SO2 emission concentration are guaranteed.

The invention discloses a multi-target joint optimized antibiotic molecule design system and method applied to the field of biological medicine, and the method comprises the steps: obtaining FabI enzyme and AcrAB-TolC efflux pump structure data, extracting double-target space and physicochemical characteristics, and constructing a joint pharmacophore model containing a FabI inhibition domain and an efflux pump blocking domain; screening candidate molecules meeting a double-domain space matching threshold, screening high-affinity double-target molecules through conformation sampling and free energy calculation, and forming a lead compound library through multi-layer filtration of metabolic stability, membrane penetrability, quantum chemical properties and synthesis feasibility; carrying out electron effect, chain length or heteroatom fine tuning on dominant molecules through in-vitro bacteriostasis and efflux inhibition experiment feedback, and carrying out iterative optimization until MIClt is met; 2 [mu] g / mL and the efflux inhibition rate is gt; according to the present invention, the antibacterial effect and the drug resistance inhibition ability are significantly improved, the molecular synthesizability and the biological safety are ensured, and the engineering design new path is provided for the Gram-negative bacterium drug resistance crisis.

The invention relates to the field of control, in particular to a flight attitude control method and system for an unmanned aerial vehicle, and the method comprises the steps: obtaining an expected attitude angle instruction and actual attitude angle feedback of the unmanned aerial vehicle, calculating an attitude angle error, employing a tracking differentiator to calculate a transition process for the expected attitude angle instruction, and enabling a tracking rate factor to achieve the control of the flight attitude of the unmanned aerial vehicle when the instruction is subjected to step change. Based on initial attitude angle error setting, instruction smooth transition is ensured, based on a transition signal output by a tracking differentiator and an estimated value of an expansion state observer, a basic control quantity is generated through nonlinear state error feedback, and control gain is adjusted on line according to a lumped disturbance amplitude. And predicting the lumped disturbance historical sequence by using a grey prediction model, calculating a predicted value at a future moment, and carrying out algebraic summation on the basic control quantity, a compensation component of the lumped disturbance predicted value and a gyroscopic moment decoupling component to generate an attitude control moment signal so as to realize stable flight of the unmanned aerial vehicle.

The invention relates to the technical field of polypeptide biosynthesis, in particular to a method for biosynthesizing acetyl tetrapeptide-5, a composition containing the acetyl tetrapeptide-5 and application of the composition. According to the method, low-cost natural amino acid is used as a substrate, specific aminopeptidase or a mutant thereof is used as a biocatalyst, amino acid ligase and polyphosphatase are combined, and acetyl tetrapeptide-5 can be efficiently synthesized through a one-step enzymatic reaction. Compared with a traditional chemical synthesis method, the method has the advantages of low raw material cost, no use of an organic solvent, mild reaction conditions, high regioselectivity, environmental friendliness, low production cost and the like. The invention also provides a composition containing acetyl tetrapeptide-5 and dipeptide-15, the inhibition effect of the composition on grease secretion is obviously better than that of a single component, and the composition has a synergistic oil control effect under a specific ratio.

The invention discloses a wave pitching motion control method and system for an offshore floating type wind turbine generator, and belongs to the technical field of offshore wind power equipment control. The method comprises the following steps: signal acquisition: acquiring unit operation state, marine environment and pitching motion state parameters in real time; wave load prediction: predicting a future wave load based on the improved LSTM neural network model; evaluating a pitching motion state, pre-judging a motion trend through a kinetic model, and judging whether the motion trend exceeds a safety threshold value or not; cooperative control instruction generation: generating cooperative control instructions for fine tuning of a variable pitch angle, a generator torque and a cabin yaw angle based on an MPC algorithm; and control execution and feedback correction: driving an execution mechanism to act and dynamically correcting a control instruction. By accurately predicting the wave load, cooperatively adjusting multiple controllable components and dynamically correcting, efficient and accurate suppression of pitching motion is achieved, and the unit operation stability, the wind energy capturing efficiency and the equipment safety are improved.

The invention discloses a large-scale wind turbine generator power load cooperative fault-tolerant control method. The method comprises the following steps: establishing a unit load and rotating speed control model considering a variable pitch actuator fault; according to the load and rotating speed control model, a fault-tolerant independent variable-pitch controller composed of a centralized variable-pitch ring, an independent variable-pitch ring and a fault-tolerant compensation ring is constructed for the three-blade variable-pitch actuator; and the fault-tolerant independent variable pitch controller inputs variable pitch given instructions corresponding to the blades to the corresponding variable pitch actuators, and the variable pitch actuators implement fault-tolerant variable pitch with the variable pitch given instructions as reference, so that power and load cooperative control under the fault working condition is achieved. According to the method, the optimization effect and the application capability boundary of pneumatic unbalanced load suppression of the wind wheel of the unit can be improved under the combined action condition of multi-source disturbance and variable-pitch actuator faults, meanwhile, the high stability of power output is guaranteed, and high-performance power-load cooperative control is achieved.

The application relates to a thioether-containing pleuromutilin derivative, a preparation method and application thereof; the structural formula is shown in formula H; through antibacterial activity test on the thioether-containing pleuromutilin derivative, it is proved that the thioether-containing pleuromutilin derivative has good antibacterial activity on rice bacterial leaf blight, rice bacterial disease and citrus canker bacteria. The thioether-containing pleuromutilin derivative can be applied to preparation of a rice bacterial disease prevention and control agent, and the preparation method is simple, and the production cost is low.

The present application provides the use of raltitrexed in the manufacture of a medicament for the treatment of diseases caused by adenovirus infection, including but not limited to respiratory tract infection, gastrointestinal infection and keratitis caused by adenovirus. When raltitrexed was tested for its anti-adenovirus activity at the cellular level, using a viral infection dose of 100 TCID50, the viral infectivity was determined on a human non-small cell lung cancer cell line (A549 cell) model, and the results showed that raltitrexed had a significant inhibitory effect on adenovirus, with an EC 50 = 8.98 nM, a CC 50 > 187.5 nM, and it was found that it had a significant inhibitory effect on the entry of the virus into the cell; and in the hDSG2 mouse model, a significant inhibitory effect of raltitrexed on viral replication was also observed. Therefore, raltitrexed can be used to treat diseases caused by adenovirus infection.

The application discloses application of a naphthalene nitrile derivative in preparation of an antitumor pharmaceutical composition, in particular, application of a 2-(imino)-naphthalene nitrile derivative in preparation of an antitumor pharmaceutical composition. The 2-(imino)-naphthalene nitrile derivative provided by the application has a significant inhibiting effect on colon cancer, liver cancer, lung cancer, prostate cancer, cervical cancer, neuroglioma and breast cancer, exhibits excellent antitumor characteristics, can be used as a leading drug molecule for resisting tumors, and has a good development and application prospect in development of antitumor drugs.

The application discloses a five-heterocycle compound, a preparation method and application thereof. Specifically disclosed are a compound as shown in formula I, a pharmaceutically acceptable salt or solvate thereof, a composition containing the compound, and a pharmaceutical use of the compound for preparing a drug for treating a disease or disorder related to the mechanism of action of KRAS G12C mutant protein. The five-heterocycle compound in the application has the activity of inhibiting the proliferation of Ba / F3 KRAS-G12C cells, NCI-H358 cells and MIA PaCa-2 cells expressing KRAS G12C mutant protein, and has a good inhibitory effect on the growth of a subcutaneous transplanted tumor of a NCI-H358 nude mouse.

The invention belongs to the technical field of power equipment state monitoring, and discloses a transformer discharge detection method and system with an anti-interference function, and the method comprises the steps: obtaining a multi-mode discharge original signal of a transformer, carrying out the synchronization of a coefficient through a channel, anchoring a synchronous interference signal, extracting initial multi-dimensional features, and carrying out the detection of the multi-mode discharge original signal. Performing weighted average fusion on the initial multi-dimensional features according to a channel synchronization coefficient to obtain an anti-interference feature vector; constructing a feature screening-interference immune lightweight neural network model, inputting anti-interference features, taking a channel synchronization coefficient as an interference immune factor, and outputting a discharge type identification result; and obtaining an evaluation index by combining the peak amplitude of the multi-mode discharge original signal of the transformer after the de-noising preprocessing, and obtaining a discharge risk level based on the evaluation index. According to the invention, accurate identification and risk grade evaluation of transformer discharge are realized, and the problems of poor anti-interference performance and the like are solved.

The invention discloses a biological agent for preventing and treating panax notoginseng root rot, and relates to the technical field of biological prevention and treatment, the biological agent is composed of four layers of functional florae: an A layer of sentinel-decoding flora is used for identifying a pathogen quorum sensing signal and is used as an event trigger source, a B layer of metabolic countering flora is used for decoupling conversion of disease-promoting saponin and controllable release of a metabolic false substrate, and a C layer of functional florae is used for controlling root rot of panax notoginseng. The C-layer self-healing conductive biological membrane construction flora forms a biological membrane with conductivity and self-healing capability on the root surface, and the D-layer electrically-enabled flora constructs stable biological micro-current at the rhizosphere by using ferric oxide particles as external electron acceptors. The layer A triggers to cause controlled release of the layer B, a conversion product of the layer B provides a carbon source and a structural unit for the layer C, and a conductive network of the layer C and the layer D form an electronic path. The biological agent is used for early recognition and continuous inhibition of pathogens in panax notoginseng planting soil, can start defense response in the early stage of quorum sensing signal occurrence, and keeps action stability under complex environmental conditions.

The invention discloses insect lysozyme capable of preventing and treating rice virus diseases and application of the insect lysozyme. According to the invention, three pieces of lysozyme (RdLYZI1, RdLYZC1 and RdLYZC2) with remarkable inhibitory activity on various rice viruses are innovatively excavated from the body of a natural transmission vector insect of the viruses, and the amino acid sequences of the lysozyme are shown as SEQ ID NO.13, SEQ ID NO.14 and SEQ ID NO.15. The invention further discloses a preparation method of the lysozyme. Experimental verification shows that the lysozyme RdLYZI1, the lysozyme RdLYZC1 and the lysozyme RdLYZC2 can effectively inhibit replication and accumulation of various rice viruses in plants and vector insects, have a remarkable prevention and treatment effect on related virus diseases and relieve plant growth obstacles caused by the viruses. The invention provides a novel biological prevention and control strategy which is environment-friendly and high in targeting property for green prevention and control of rice virus diseases, and has an important application prospect.

The invention discloses a lactobacillus brevis with broad-spectrum bacteriostatic activity and a separation method and application thereof, and belongs to the technical field of microorganisms, in particular to a lactobacillus brevis AW04 with broad-spectrum bacteriostatic activity, which is characterized in that the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, and the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection. The address is Wuhan University Campus, Wuchang District, Wuhan City, Hubei Province; the postcode is 430072; the preservation number of the strain is CCTCC M 20241970; the preservation date is September 13, 2024. The strain provides a novel, safe and efficient strain resource for developing microecological preparations, feed additives or veterinary drugs for preventing and treating bacterial diarrhea of animals such as calves and the like, and has important value for reducing the use of antibiotics in the breeding industry and coping with bacterial drug resistance crisis. The strain can be produced on a large scale by using the existing fermentation technology and is convenient to apply.

The waterproof elastic bandage with the good breathability comprises a hydrophobic layer, a breathable layer and a deformation layer, and the breathable layer is of a corrugated structure; the deformation layer is made of a skin-friendly elastic material; the breathable layer is made of a polytetrafluoroethylene material; the lower surface of the hydrophobic layer is fixedly attached to the upper surface of the breathable layer, and the lower surface of the breathable layer is fixedly attached to the upper surface of the deformation layer. Compared with the prior art, the waterproof elastic bandage with the good air permeability has the advantages that the corrugated polytetrafluoroethylene breathable layer is arranged, so that the bandage is waterproof, and meanwhile, the bandage with the same area has better air permeability.

The present application relates to the preparation method and application of the tri-substituted anisoles containing N-propyl alcohol group indole structure, and the compounds have the structural formula shown in general formula (I). The present application relates to the compounds of general formula (I) having the effect of strongly inhibiting L858R / T790M / C797S and Del19 / T790M / C797S drug-resistant mutant EGFR kinase, and further relates to the use of the compounds and pharmaceutically acceptable salts thereof in the preparation of drugs for treating and / or preventing diseases caused by drug-resistant mutations of EGFR kinase, especially in the preparation of drugs for treating and / or preventing cancer. The present application also provides the preparation method of the compounds, and the pharmaceutical compositions and uses containing them. Especially for preparing drugs for treating and / or preventing lung cancer, having good application prospect of anti-tumor drug development. (I)

The invention belongs to the technical field of chemical prevention and control of agricultural diseases and insect pests, and provides an antiviral heterocyclic compound. The heterocyclic compound has a relatively good inhibition effect on plant viruses, has passivation, protection and treatment effects after being applied to plants, is superior to a commercial medicament virazole, has good biological activity and has a commercial prospect; the invention also provides a composition containing the heterocyclic compound. When the composition contains ningnanmycin, the two components have a remarkable synergistic effect in a certain proportion range, and the resistance risk of a single agent can be reduced. The invention provides a new medicament for preventing and treating plant viruses, and has important practical application value.

The application relates to the technical field of biological medicine, in particular to a medicine for combined treatment of tumors by using a recombinant oncolytic virus and a small-molecule anticancer drug. The method comprises the following steps: combined treatment of tumors by using a recombinant oncolytic virus and a small-molecule anticancer drug; the small-molecule anticancer drug is a small-molecule anticancer drug targeting Parp; the recombinant oncolytic virus comprises M protein, G protein, N protein, P protein and L protein after site-directed mutagenesis. The application can kill tumor cells by using a recombinant oncolytic virus and a small-molecule anticancer drug, and the curative effect is 1+1>2.

This invention belongs to the field of biological agents for aquaculture, and discloses a compound biological pond-cleaning agent containing tea saponin and its preparation method. The compound biological pond-cleaning agent of this invention comprises the following components by weight: 3-10 parts tea saponin, 60-70 parts roe beetle root powder, 10-20 parts Buddleja officinalis, 5-10 parts compound microbial powder, 3-8 parts adjuvants, and 10-20 parts carrier; the adjuvant is a mixture of sodium lignin sulfonate and sodium dodecylbenzene sulfonate; the compound microbial powder is a mixture of Bacillus subtilis and photosynthetic bacteria; and the carrier is diatomaceous earth. This invention combines three natural active ingredients—tea saponin, roe beetle root powder, and Buddleja officinalis—with suitable adjuvants and a carrier, which can expand the pond-cleaning range and has good killing or inhibitory effects on harmful organisms such as wild fish, shrimp, crabs, and snails, as well as various pathogens. The pond-cleaning is thorough, and the raw materials are easily degradable, leaving no residue. It is environmentally friendly and has a long-lasting effect, which is of great significance for promoting the green and sustainable development of aquaculture.

This application discloses a purino[1,2-a]carbazolin derivative, its preparation method, and its application. Specifically, it discloses a compound having the structure shown in Formula I, or its stereoisomers, solvates, metabolites, pharmaceutically acceptable salts, cocrystals, or prodrugs: ; wherein R1 and R2 are each independently selected from hydrogen, hydroxyl, carboxyl, substituted or unsubstituted C1-C6 alkyl, -CONH-R3, and -COO-R4; wherein R3 is a substituted or unsubstituted C1-C5 alkyl, and the substituent can be any of cyano, halogen, alkylC1-C5 alkoxy, C1-C5 alkylsulfonyl, di(C1-C5 alkyl)amino, nitrogen-containing heterocyclic, aryl, and C1-C5 heteroaryl; R4 is selected from any of substituted or unsubstituted aryl C1-C5 alkyl and nitrogen-containing saturated heterocyclic C1-C5 alkyl. This compound can be used as a TDP1 inhibitor for antitumor therapy.

The embodiment of the application provides a false alarm suppression method, device and medium for ground-based telescope observation, through research on the constructed false alarm data set, various false alarm characteristics can be fully obtained for different false alarm categories, based on trajectory quality characteristics, sky light identification coefficient, target identification coefficient, hot pixel identification coefficient, space-time geometric consistency, gray consistency, speed size consistency, long axis and speed size consistency, long axis and speed direction consistency, the uncertainty of the traditional experience threshold discrimination method can be got rid of, not only various scene false alarms can be effectively identified, but also false suppression of real targets can be prevented to cause missed alarms, and the false alarm suppression method is suitable for target detection after false alarm suppression in different observation environments, and the false alarm suppression effect is good.

This invention discloses a nanoRNA delivery system and its application in the control of Sclerotinia sclerotinia disease, relating to the field of biotechnology. The preparation method of the nanoRNA delivery system includes the following steps: mixing chitosan, sucrose, and aspartic acid uniformly and then subjecting them to a hydrothermal reaction to obtain a quantum dot-chitosan degradation product complex; mixing the quantum dot-chitosan degradation product complex with double-stranded RNA to obtain the nanoRNA delivery system; the double-stranded RNA is used to silence Sclerotinia sclerotinia virulence-related transcription factor genes. The nanoRNA delivery system provided by this invention can effectively protect RNA and exhibits a very high inhibitory effect on Sclerotinia sclerotinia in plants, providing a novel technical solution for the green and precise control of Sclerotinia sclerotinia disease.

The application of 2-[(7-hydroxy-8-methyl-2-oxochrome-4-yl)methylthiosulfase]-4,6-dimethylpyridine-3-carbamate in the treatment of Ebola virus belongs to the field of pharmaceutical technology. This invention addresses the technical problem of the lack of effective anti-Ebola virus drugs in the prior art by providing 2-[(7-hydroxy-8-methyl-2-oxochrome-4-yl)methylthiosulfase]-4,6-dimethylpyridine-3-carbamate, which can effectively inhibit Ebola virus replication within a non-toxic range. The compound exhibits good anti-infective effects against SUDV, BDBV, and TAFV viruses and can be used to prepare safe and effective broad-spectrum anti-Ebola virus drugs.

This invention discloses a Tibetan bath composition compound and its preparation method, relating to the field of daily chemical products technology. The Tibetan bath composition compound consists of a ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder, Bacillus subtilis, Tibetan medicine composition, starch, anhydrous citric acid, sodium bicarbonate, calcium citrate, crospovidone, and magnesium stearate. Bacillus subtilis is used to ferment the ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder to obtain a fermentation-modified porous carrier, which is then loaded with the Tibetan medicine composition to form a Tibetan medicine inclusion powder. This not only achieves efficient drug delivery through a triple mechanism of biomodification, metabolite synergy, and structural optimization, but also forms a quaternary system with Terminalia chebula. The effervescent effect also enhances the penetration of Tibetan medicine components, which is beneficial for better exerting the antibacterial and anti-inflammatory effects of active substances, and significantly improving fungal infections and eczema-related skin problems.

The present application relates to the chemical medicine field, specifically, it relates to a kind of anti-tumor calophyllol derivative, preparation method and application, the calophyllol derivative has good inhibitory effect on thioredoxin reductase activity, and it is found that the molecule inhibits the activity of thioredoxin reductase by inhibiting the selenium cysteine of thioredoxin reductase carbon end, and then kills tumor cell, and then obtain the anti-tumor candidate drug with higher activity and better pharmacokinetic characteristics.

The application discloses a signal strength and sidelobe suppression combined optimization elastic Doppler complementary waveform design method, first proposes a Pareto effective framework for Golay complementary waveform design, and the framework jointly optimizes a Doppler elastic transceiving sequence pair. The framework considers a constrained optimization problem in terms of SMR and SNR, constructs a loss function of a Pareto multi-objective optimization problem by using an epsilon-constraint method, and obtains all possible Pareto optimal solutions. Secondly, in order to solve the optimization problem, a model-driven machine learning algorithm is innovatively designed to process the multi-objective optimization problem. The application effectively reduces the interference of sidelobes on weak target detection, improves the accuracy and reliability of target detection of a radar system, can more clearly detect and distinguish multiple targets, and enhances the overall performance of the radar system.

The application discloses application of pyrroloquinoline quinone in inhibition of iron imbalance and preparation of an iron imbalance inhibition drug, the pyrroloquinoline quinone can be used as an iron homeostasis regulator or an iron imbalance inhibitor, can significantly maintain iron homeostasis in cells and / or tissue organs, inhibits iron imbalance in cells and / or tissue organs, and provides a new choice for research and development of safe and efficient iron homeostasis regulator and / or iron imbalance inhibitor related drugs.

The invention provides a harmonic current control method, a controller and an inverter, and is applied to the technical field of inverters, and the method comprises the steps: taking a half switching period of the inverter as a sampling period, carrying out the sampling of the output current of the inverter, obtaining a first sampling result corresponding to the current sampling period and a second sampling result corresponding to the last sampling period, the current sampling period is adjacent to the previous sampling period, and the determination of the target sampling current multiplexes the sampling result of the previous sampling period, so that the harmonic control signal is generated based on the target sampling current. Therefore, the sampling result in the complete switching period duration is obtained in the half switching period, the duration for determining the target sampling current is effectively shortened, the delay duration for generating the harmonic control signal is further shortened, the timeliness of the harmonic control process is ensured, and the stability of the harmonic control process and the harmonic current suppression effect are improved.