785 results about "Benzoyl chloride" patented technology

The invention discloses a polyimide liquid crystal vertical alignment agent, a prepration method and a liquid crystal box prepared thereby. The liquid crystal vertical alignment agent is prepared by dissolving soluble polyimide which accounts for 2.5-5% of the weight of the alignment agent into an organic solvent, the soluble polyimide is prepared by leading 1-50 parts by weight of tetracarboxylic dianhydride, 1-50 parts by weight of diamine with a special structure, 1-50 parts by weight of diamine and 40-80 parts by weight of organic solvent to react under the protection of nitrogen and at the temperature of 160-180 DEG C for 5-12 hours, and the diamine with the special structure is prepared by leading HO-B-OH, a catalyst, the organic solvent, halogenated hydrocarbon X-R and dinitro-substituted benzoyl chloride to carry out three-step reaction. The polyimide of a liquid crystal vertical alignment film formed by using the liquid crystal vertical alignment agent disclosed by the invention is soluble, a pretitle angle of the liquid crystal box prepared by spin-coating the polyimide liquid crystal vertical alignment agent is close to 90 degrees, and a liquid crystal display prepared thereby has excellent performances of fast response, wide viewing angle, high contrast degree and the like.

The invention relates to a method for purifying cyclic solvent in producing TDI, particularly relates to the case that if the abnormal condition that group impurities containing -NCO such as TDI, CI-TDI, m-CBC and the like are carried by the cyclic solvent DEIP occurs in producing toluene diisocynate (TDI) by a heavy solvent phosgene method, the -NCO group impurities react with TDA and phosgene in a photochemical process to lower TDI yield and generate urea and acid amides residual substances to lead to the problem that production is stopped to clean away obstruction due to the blocking of pipelines and device. The invention uses a processing method of reacting PEG or C2H5OH with -NCO group impurities, adopts rectification to separate the generated heavy components from DEIP to obtain pure DEIP at the tower top to return to a storing bank of the cyclic solvent, and the tower bottom obtains the reacted NCO components and original heavy component residual removal system, thus ensuring smooth operation of the device.

The invention discloses a synthesis method of synthesizing florfenicol. The synthesis method comprises the following steps: L-threo-(p-(methylsylfonyl) phenyl) serine ethyl ester which is used as raw material is processed by the protection by a protecting group, configurational transition, hydrolyzation, acetylation, re-protection, deoxidation, fluorination, and pre-hydrolyzation, so that the florfenicol is obtained, wherein, the protecting group R is one of benzoyl chloride, phthalic anhydride, cyanophenyl, and allyl compounds; the configurational transition is performed when sodium alcoholate or sodium methoxide exists. The raw material which is used in the method is a byproduct which is generated during the process of preparing thiamphenicol, is easy to get in the market, and is inexpensive; the technological operation is simple, the cost is low, the yield rate is high, and the synthesis method has industrialized value.

The invention relates to a new process of supercritical CO2 dyeing of ramie fiber, using ramie fiber as raw material, swelling by NaOH solution and modifying by benzoyl chloride, and dyeing with dispersive dye in supercritical CO2 medium by supercritical fluid technique. And its advantages: it is a clean producing process; the dyed ramie fiber has characters of bright color, short dyeing flow, dyeing uniformity, good color intensity, low synthetic cost, and remarkable economic and environmental protection benefits. And it also reveals a process device implementing the dyeing method, suitable to spread and apply in spinning and weaving, and printing and dyeing enterprises.

A method for making platform molecules comprising: reacting 4-alkoxy benzoyl chloride with R²-hydroquinone under first conditions effective to produce bis 1,4[4-alkoxy-benzoyloxy]-R²-phenylene comprising bis terminal alkoxy groups wherein R² is a bulky organic group; and, subjecting the bis 1,4[4-alkoxy-benzoyloxy]-R²-phenylene to second conditions effective to selectively cleave the bis terminal alkoxy groups to produce a solution comprising complexes comprising diphenolic platform molecules comprising bis terminal hydroxyl groups, the second conditions also being effective to precipitate the complexes out of the solution.

The invention discloses a preparation process of benzoyl chloride. The preparation process comprises the following steps of synthesis of benzotrichloride: carrying out temperature reaction on methylbenzene and chlorine under the catalytic action of a catalyst to synthetize a crude benzotrichloride product; synthesis of the benzoyl chloride: continuously stirring and heating the crude benzotrichloride product and benzoic acid to prepare a crude benzoyl chloride product after adding the catalyst; refining of the benzoyl chloride: carrying out reduced pressure distillation on the crude benzoyl chloride product to prepare a refined benzoyl chloride product; recovering benzoyl chloride raffinate, adding water to the benzoyl chloride raffinate which is subjected to the reduced pressure distillation, heating and stirring to transform the benzoyl chloride contained in the raffinate into the benzoic acid, cooling, then separating out benzoic acid. The preparation process disclosed by the invention is easy to safe to operate, effectively shortens the reaction time, achieves the purity of the prepared benzoyl chloride by 99.5%, reduces the environmental pollution by recycling residues, saves the resources, reduces the cost, meets the requirements of pharmaceutical chemicals and can carry out massive industrial production.

The invention belongs to the technical field of analysis chemistry and relates to a copper ion fluorescence probe and a synthetic method of the copper ion fluorescence probe. The copper ion fluorescence probe disclosed by the invention has a chemical name of 8-[di(2-picolyl)amine-3-benzyl]-4, 4-difluoro-1,3,5,7-tetramethyl-4-boron-3a, 4a-dipyrrole (called BODIPY-DPA for short). The synthetic method of the copper ion fluorescence probe comprises the steps of: mixing 2, 4-dimethylpyrrole with 3-chloromethyl benzoyl chloride, then adding CH2Cl2 into the mixture, then adding boron trifluoride for reaction, and then orderly adding di(2-picoly)amine and triethylamine for reaction, at last, obtaining the copper ion fluorescence probe. The BODIPY-DPA shows light yellow in the solution, has high fluorescence emission at 590 nm, can enter HepG-2 to show green fluorescence imaging, and has a lowest limit of detection of 2.78 muM on copper ions in water solution. The copper ion fluorescence probe prepared by the synthetic method is characterized in low toxicity and the inhibition rate of 100 muM of HepG-2 is smaller than 10%, so the copper ion fluorescence probe can be used for detection of living cell imaging and copper irons in the cell, and has a very good application prospect in environment monitoring and detection of copper irons in a biologic system.

The invention relates to a main drying unit of a slurry or powder continuous drying system, applying to evaporation and collection of phosphorus slurry and phosphorus contained in dregs, raffinate treatment of calcium oxide or calcium chloride and benzoyl chloride, drying of chemical products, comprehensive recovery treatment of three wastes and the like. The main drying unit comprises a spindle and multiple layers of circular chambers arranged from top to bottom. The circular chambers are movably hermetically fitted to the spindle through center through holes, and scraper plates distributed in the different circular chambers are fixed on the spindle. Each two adjacent circular chambers which are spaced by a gap are connected hermetically through a discharging passage. The circular chambers are arranged in a heat-conducting liquid container. A feed inlet and an exhaust outlet are arranged on the top circular chamber, and a discharge outlet is arranged at the bottom of the bottom circular chamber. The main drying unit is adaptable to continuous drying of slurry or powder, is efficient in production, environmental friendly, safe and energy saving. Since the slurry or powder is evaporated layer by layer, the volatilization area is wide, and both the evaporation efficiency of volatile matters and the recovery rate of the volatile matters are high.

Disclosed is an asymmetric total-synthesis method for chiral huperzine a. The method takes 1,4-dihydro-spiro (4,5) -8 -decanone as starting material to get benzoate through hydroxymethylation and the treatment of benzoyl chloride and K2CO3; the benzoate is reacted with hydrogen sulfate O-methyl iso urea to get quinazoline; after the ketal is eliminated, Mander reagent is used for methyl esterification reaction so as to obtain beta-keto ester. Chiral ammonia, such as cinchona alkaloid, is used to promote the tandem asymmetric Michael addition/aldol condensation reaction of beta-keto esters and methyl acrolein. The compound carboxylate of diastereoisomer is reacted with MsCl, triethylamine and DMAP to get transformed. Through TMSI and MeOH processing, the protective group is removed so as to obtain optically pure-chiral huperzine a.

The invention relates to a biosurfactant having the general structure shown in formula (I). The preparation method of the biosurfactant comprises following steps: taking a mass-produced protein which is one selected from soybean isolate protein, corn protein powder, wheat protein powder or fish scale collagen protein as a raw material; performing hydrochloric acid hydrolysis or enzyme catalytic hydrolysis so as to obtain polypeptides with different hydrolysis degrees; and then subjecting the polypeptides to acylation reaction with oleoyl chloride, lauroyl chloride, decanoyl chloride, or benzoyl chloride. The biosurfactant possesses excellent emulsifying property and surface and interfacial activity, can be used alone as an oil displacement agent, and can also be combined with other surfactants and then used in tertiary oil recovery.

The invention discloses a room temperature phosphorescent compound and a preparation method, a single crystal culture method and application thereof in the field of anti-counterfeit. According to the invention, through acylation reaction with the participation of aluminum trichloride or sodium hydride, benzoyl chloride and derivatives thereof react with carbazole, benzoyl or derivatives thereof are connected with carbazole through N atoms, and by changing R groups connected with the benzoyl, three room temperature phosphorescent compounds CPM (R=H), CMPM (R=CH3) and CMOPM (R=OCH3) are obtained, and then the three compounds are cultured into single crystals through a solvent volatilization method by using two solvents with different solubility, boiling point and volatility. The obtained single crystals can be used in the field of anti-counterfeit, and can be matched with a material with better fluorescence-emission ability in use to complete two modes: color reliquid and time reliquid. Especially, the phosphorescence life of the obtained compound CPM at room temperature reaches 748ms, so that the compound CPM can be practically used in the field of anti-counterfeit.

The invention discloses a polyether hydrophilic modifier with a zwitter-ion group, which has a structural formula as described in the specification. The invention further discloses the preparation method of the polyether hydrophilic modifier with the zwitter-ion group. The preparation method comprises the following steps: (1), synthetizing polyether containing a tertiary amine group; (2), synthetizing the polyether with the zwitter-ion group. A water dispersible polyisocyanate composition is prepared through the following steps: enabling polyisocyanate and the polyether hydrophilic modifier with the zwitter-ion group to react under the effect of a catalyst for 2.5 to 3 hours, then adding benzoyl chloride, and stopping the reaction. According to the invention, a water dispersible polyisocyanate curing agent prepared by the zwitter-ion modifier is better in emulsibility, only less hydrophilic modifier is added to enable the polyisocyanate curing agent to have a better water dispersity. Influences from pH value to the emulsion stability of the curing agent can be reduced, and the working life of the polyisocyanate curing agent is improved.

The invention discloses a method for synthesizing 3,5-dichlorobenzoyl chloride. The method comprises the following steps: carrying out sulfonation on benzoyl chloride by sulfur trioxide to obtain 5-chloroformyl metaphenylene disulfonic acid; carrying out chlorination by catalyzed triphosgene to obtain 5-chloroformyl metaphenylene disulfuryl chloride; finally, carrying out removal of sulfur dioxide chlorination to obtain 3,5-dichlorobenzoyl chloride. Compared with an existing preparation method, the method disclosed by the invention has the characteristics of stable chlorinating agent, high production safety, small amount of three wastes, no requirement for recovering and treating a great amount of dangerous byproducts, no requirement for refining a coarse product, low production cost and the like and is suitable for industrial production.

The invention relates to a synthesis method for cationic bleaching activating agents with surface activity, belonging to the field of fine chemical engineering. According to the method, a series of cationic bleaching activating agents with different carbon chain-length quaternary ammonium salt groups are synthesized by adopting alkyl dimethyl tertiary amine, 4-(chloromethyl)benzoyl chloride and lactam as intermediates. The leaching activating agent has stronger affinity on the surface of a material with surface electronegativity in an aqueous solution, can react with hydrogen peroxide on the surface of the material to produce extremely active peroxy acid, can bleach the material at a low temperature so as to effectively remove the pigment impurities on the surface of the material. The cationic bleaching activating agent can be used for industrial bleaching and household washing of textiles.

The invention discloses a preparation method of amphipathic acrylic acid/maleic anhydride (AA/MA) grafted esterified hydroxypropyl cassava starch. The preparation method comprises the following steps of: taking cassava starch as a major raw material and anhydrous ethanol as a solvent, carrying out an etherification reaction with propylene epoxide in an alkaline medium to obtain hydroxypropyl cassava starch; synthesizing esterified hydroxypropyl starch by taking benzoyl chloride as an esterifying agent, and implementing graft copolymerization on esterified hydroxypropyl starch and a monomer solution obtained by the neutralization of acrylic acid and ethidene diamine so as to synthesize the amphipathic AA/MA grafted esterified hydroxypropyl cassava starch. For the amphipathic AA/MA grafted esterified hydroxypropyl cassava starch, the substitution ratio of hydroxypropyl is 0.18-0.36, the substitution ratio of esterification is 0.089-0.12, and the grafting efficiency and the conversion ratio of a monomer are respectively 44.0% and 63.4%. According to the preparation method disclosed by the invention, propylene epoxide and acrylic acid are adopted as hydrophilic groups to modify the cassava starch, and then benzoyl, methyl acrylate and other hydrophobic groups are bonded, so that the amphipathic AA/MA grafted esterified hydroxypropyl cassava starch simultaneously has negative ions and hydrophobic groups and can be widely applied to fields of environmental protection, ecological repair, water treatment, heavy metal absorption and the like by being taken as an environment material.

The invention relates to a preparation method of 2-(p-amino phenyl) benzimidazole-5-amic, including the following steps: (A) p-Nitro o-phenylendiamine and p-Nitro benzoyl chloride are adopted as materials which are processed through condensation, cyclization and dehydration one-pot method for synthesizing the benzimidazole compound shown as the formula (II); and (B) the compound of the formula (II) is subjected to catalytic hydrogenation to obtain the final product. The preparation method is characterized in that the manufacturing efficiency is high; and the synthesizing cycle is short and the reducing technique is environment-friendly. As a green synthesizing technique, the method overcomes the contamination problem troubling people for years.

The invention relates to a preparation method of high-purity imatinib, which comprises the following steps: taking 4-[(4-methyl-1-piperazine) methyl] benzoyl chloride dihydrochloride and N-(5-amino-2-methyl phenyl)-4-(3-pyridine)-2-pyrilamine as raw materials, taking acetonitrile or pyridine as a solvent, and adding triethylamine as an acid-binding agent when the acetonitrile is taken as the solvent to react at the reaction temperature of -5-50 DEG C; removing the solvent in the reaction liquid to recycle the solvent; adding water into the residues; extracting impurities by ethyl acetate; separating the organic phase from the water phase; then neutralizing the water phase by ammonia water until the PH is 9-10; and adding saturated fatty alcohol to precipitate imatinib crystals. Because the purity of the product obtained by the preparation method of the invention is higher than 99.5%, the single impurity is less than 0.10%, and the solvent has low dosage and can be recycled, the production cost can be greatly reduced, and the pollution on the environment can be reduced. Moreover, the method has simple operation processes and mild reaction conditions, thus the method is suitable for industrialized production.

The invention relates to a method for preparing a rubber auxiliary agent, and particularly discloses a method for preparing rubber peptizer 2,2-dibenzoylamino diphenyl disulphide (DBD). The method for preparing the rubber peptizer DBD is characterized by comprising the following steps of: performing ring opening reaction on benzothiazole to obtain a ring opening product; oxidizing the ring opening product to prepare diphenylamine disulphide; and performing acylation reaction on the diphenylamine disulphide and benzoyl chloride to generate the DBD. According to the method for preparing the rubber peptizer DBD, compared with the conventional process, the product cost is remarkably reduced; the method is favorable for popularization and application of the environmentally-friendly peptizer DBD, and simultaneously breaks through the situation that the product depends on import for a long term; the organic solvent is used as a reaction medium and can be recycled, so little three-waste is discharged; and the production flow is simple and easily controlled, high-temperature and high-pressure reaction does not exist in the method, the equipment investment is low, and the method is easy for production and operation.

The invention relates to a method for synthesizing flavone compounds, in particular to a method for synthesizing 5,7-dihydroxyflavone. The method comprises the following steps: in the presence of a condensing agent, reacting an active methylene compound (ethyl acetoacetate) with an acylating agent (benzoyl chloride), and importing benzoyl into the active methylene; selectively hydrolyzing the obtained product by utilizing ammonium chloride solution so as to remove acetyl, thus obtaining ethyl benzoylacetate; mixing the obtained intermediate with phloroglucinol to dissolve the obtained intermediate, then warming, vacuumizing and reacting to obtain a crude product; and refining the crude product by utilizing DMF (dimethylformamide) and ethanol so as to obtain the 5,7-dihydroxyflavone. The method provided by the invention has the advantages of rich sources of feed, low cost and short reaction step, and is simple in operation; and meanwhile, through the optimization of reaction conditions, the method also has the advantages of short reaction step, high yield, low cost, less environmental pollution and the like. The products prepared by the method can be used for preparing medicaments and the like.

The invention relates to a method for preparing a rubber peptizing agent, namely a 2,2'-dibenzamido diphenyl disulfide compound. The method comprises the following steps of: putting diphenyl disulfide, a deacid reagent, namely triethylamine, and a solvent in a reactor, stirring at room temperature, and slowly dropping benzoyl chloride, wherein the reaction time is 15-30 min; and obtaining the product by filtering, washing and drying after reacting. The mol ratio of the diphenyl disulfide to the deacid reagent to the benzoyl chloride to diethyl ether is (1.0-1.2):(2.0-2.2):(2.0-2.4):(50-70). According to the method disclosed by the invention, the nitrochlorobenzene is used as a raw material; the diphenyl disulfide is synthesized; the reaction speed is rapid; the reaction process is simple;and the purity of the obtained product is high.

The invention provides a synthetic process of poly-alpha-pyrrolidone based on anion open loop polymerization, which is characterized in that the mass ratio of butyrolactam, potassium tert-butoxide andbenzoyl chloride applied in the synthetic process is 15-20: 0.9-0.14: 0.7-3-0.99. The synthetic process includes processing of a reaction container, nitrogen filling, activation, polymerization, andpreparation of a finished production; the molecular weight of the prepared poly-alpha-pyrrolidone is 15000-20000, the product yield is 60-90%.

The invention discloses a preparation method for a photoinitiator bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide. The preparation method comprises the synthesis steps: under the protection of inert gas, carrying out a reaction of aluminium trichloride or tin tetrachloride and trimethylsilane in the temperature range of 0-100 DEG C to obtain aluminium dichloride ions, and rapidly acting with dichlorophenyl phosphine in the reaction system, to obtain a bis(aluminium trichloride or tin tetrachloride)phosphine salt intermediate; then carrying out a reaction of the intermediate and 2,4,6-trimethyl benzoyl chloride, to obtain bis(2,4,6-trimethylbenzoyl)phenyl phosphine; and under the condition of the temperature of 20-50 DEG C, oxidizing by nitrogen dioxide, to obtain the target product. The method avoids use of a dangerous active metal potassium or sodium, and adopts aluminium trichloride or tin tetrachloride with relatively low price and trimethylsilane for on-site generation of the active intermediate to achieve the reaction. The method has the characteristics of low preparation cost, simple and safe operation process, easy control of the reaction process, high product yield, good purity, easy realization of mass production and the like.

The synthesis process of benzoyl chloride is characterized by that it uses the benzoyl chloride as solvent, under the action of the iron trichloride catalyst the benzene carbonic acid and trichlorotoluene are co-heated so as to obtain the high-purity benzoyl chloride. Besides, said invention also provides its concrete steps for synthesizing high-purity benzoyl chloride. Its product yield is 95%, and its purity is 99.5%.

The invention relates to a betaine type salt-resistant polymer and a preparation method thereof. The functional monomer acrylamide propyl betaine of the polymer is synthesized by the following steps: reacting benzoyl chloride with acrylic acid in a molar ratio of 1:0.8, and distilling at reduced pressure to obtain acryloyl chloride; reacting N,N-dimethyl-1,3-propane diamine with sodium chloroacetate in an aqueous solution in an equal molar to obtain propane diamide quaternary ammonium salt; reacting acryloyl chloride with propane diamide quaternary ammonium salt in a saturated sodium carbonate aqueous solution in a molar ratio of 1.1:1; and extracting and drying to obtain the functional monomer. The functional monomer is copolymerized with acrylamide and N-alkyl acrylamide to obtain the betaine type salt-resistant polymer. The betaine type salt-resistant polymer has obvious tackifying property and anti-electrolyte effect, the viscosity of the polymer increases along with the increase of the salt concentration, and the polymer has excellent salt-resistant property especially divalent calcium and magnesium ions resisting property; and the synthesis method of the betaine type salt-resistant polymer is mild in reaction condition and simple and easy to operate, and is hopeful to be used in the aspects of salt-resistant work liquid in an oil field, daily chemical products, dyes, medicines, novel materials and the like.

The invention relates to a method for continuously synthesizing N,N-diethyl-m-methylbenzamide, belonging to the technical field of organic synthesis processes. The method is a technology characterizedby taking m-methyl benzoyl chloride and diethylamine as raw materials, taking alkali compounds of metals such as sodium and potassium as acid-binding agents, taking water as a solvent, and preparingthe N,N-diethyl-m-methylbenzamide in a continuous flow microchannel reactor. The method provided by the invention has the advantages of mild conditions, short reaction time, high raw material utilization rate, continuous operation and high production efficiency, can realize effective control in a reaction process, and is safe and stable.