556results about "Hydropoly/poly sulfide preparation" patented technology

The invention provides dihydric alcohol containing an acylhydrazone bond, dihydric alcohol containing an acylhydrazone bond and a disulfide bond, a self-repairing polyurethane elastomer and a preparation method thereof. The polyurethane elastomer is prepared from the dihydric alcohol containing the acylhydrazone bond or the dihydric alcohol containing the acylhydrazone bond and the disulfide bond and a polyurethane prepolymer. The dihydric alcohol containing the acylhydrazone bond is prepared from a dihydrazide monomer and hydroxy aldehyde. The dihydric alcohol containing the acylhydrazone bond and the disulfide bond is prepared from a dithio lipid monomer, hydrazine hydrate and hydroxy aldehyde. The polyurethane prepolymer is prepared from a polyester or polyether polyol monomer and diisocyanate. After the self-repairing polyurethane elastomer is mechanically damaged, the acylhydrazone bond or the disulfide bond on a crosslinked polymer molecular chain achieves material self-repairing through dynamic exchange reaction. The self-repairing crosslinked polyurethane elastomer material is simple in preparation, can achieve self repairing at room temperature, is high in repairing capability, short in repairing time and capable achieving many times of self repairing and has better mechanical properties.

The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

The invention relates to high base number (TBN400) vulcanized alkyl phenol calcium and a preparation method thereof. The vulcanized alkyl phenol calcium has a chemical structure as right. The preparation method is as follows: in a system containing solvent and diluent oil, alkyl phenol compound, shielded phenol compound, calcium oxide and / or calcium hydroxide and sulfur are subjected to sulfonation / neutralization reaction at a temperature of between 60 and 180 DEG C to generate phenolate intermediate; balanced calcium oxide and / or calcium hydroxide are added into the mixture, carbon dioxide is introduced, and the mixture is subjected to carbonation reaction; and alkyl polylol is added into the mixture at the sulfonation / neutralization reaction or respectively at the sulfonation / neutralization reaction and the carbonation reaction to participate in the reaction, long-chain carboxylic acid is added into the mixture at the sulfonation / neutralization reaction or respectively at the sulfonation / neutralization reaction and the carbonation reaction to participate in the reaction, and products are obtained through refining. The vulcanized alkyl phenol calcium has the characteristics of high base number, low viscosity, low precipitation number, good heat storage stability, and the like, and has excellent combination property, does not cause environmental protection problem during use, and belongs to an environment-friendly product, and adopts a one-stage process, has mild reaction conditions, and is easy to filter.

A process is provided for the manufacture of liquid polysulfide polymers. In particular, the process allows for making the liquid form of the polysulfide polymer directly and eliminates the need to first make a solid polysulfide polymer and then convert it to a liquid.

The invention relates to a Schiff base compound and a method for detecting an aniline compound thereof, belonging to the technical field of chemical sensor materials. The Schiff base compound is characterized by being prepared in such a way that an aromatic aldehyde compound with ortho-position hydroxyl reacts with monoamine or polyamine and has the structural formula shown as the figure, wherein n1 is an integer from 1 to 100, and n2 is an integer from 1 to 6; R is an aliphatic hydrocarbon substituted group, an aryl substituted group, heteroatom-substituted aliphatic alkyl or heteroatom-substituted aryl alkyl; and R1 and R2 are electron-withdrawing groups or electron-donating groups. The compound has stable solid fluorescence luminous performance, the fluorescence strength of the compound is changed by the aniline compound, the aniline compound can be detected according to the change of the fluorescence strength of the compound, and the compound is a novel fluorescence sensing material for detecting aniline.

The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.

The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic / inorganic molecules / materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2-1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention.

A process for producing methionine by (1) hydrolyzing 5-[2-(methylthio)ethyl]-2,9-imidazolinedione in the presence of a basic potassium compound; (2) precipitating methionine by introducing CO 2 into the reaction solution from the step (1) and separating the slurry into the precipitate and a mother liquid; (3) mixing the mother liquid from the step (2) with an alcohol, precipitating methionine and KHCO 3 by introducing CO 2 into the mixture, and separating the slurry into the precipitate and a mother liquid; and (4) concentrating the mother liquid from the step (3), precipitating methionine and KHCO 3 by introducing CO 2 into the concentrated solution, and separating the slurry into the precipitate and a mother liquid.

The invention relates to a bi-functional polyethylene glycol derivative and a preparation method thereof. The preparation method of the difunctional polyethylene glycol derivative comprises following steps: conducting esterification, hydrazinolysis and Curtius rearrangement in dibasic acid with disulfide bond at first to generate diisocyanate containing disulfide bond, then conducting a reaction of the diisocyanate and the polyethylene glycol to generate isocyanat-terminated polyethylene glycol and obtaining the bi-functional polyethylene glycol derivative through hydrolysis reaction of the resultant. In the invention, the preparation method has the advantages that raw materials can be gotten easily, reaction conditions are gentle, yield and product purity are high and the method is beneficial to mass production. Meanwhile, the bi-functional polyethylene glycol derivative is beneficial to both consequent reactions and controlled release of drugs and transfer of the drugs from endosome to cytoplasm. Application prospects of the bi-functional polyethylene glycol derivative are wide in surface finish of a nano-drug carrier, preparation of pro-drug and control of drug release speed etc.

Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H+ / K+-ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures.

The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic / inorganic molecules / materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2–1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention.

The present invention discloses a method for producing dimethyl disulfide by using a methyl mercaptan oxidation method. According to the method, methyl mercaptan, nitrogen dioxide, sulfur trioxide, nitric acid, hydrogen peroxide, oxygen, sulfur, and other oxidizing agents are adopted as raw materials, measures of cooling, stirring, separation, rectification, and the like are performed to obtain the reaction product dimethyl disulfide. According to the present invention, a new approach is provided for the raw materials for preparing the target product, and substantial social benefits and economic effects are provided for reduction of product cost, comprehensive utilization of resources, and reduction of environmental pollution.

A sulfur species-containing feed gas is processed in a treatment plant in which COS is hydrolyzed, and in which so produced hydrogen sulfide and other sulfur species are absorbed in a lean hydrocarbon liquid. The sulfur species in the so formed rich hydrocarbon liquid are then subjected to catalytic conversion into disulfides, which are subsequently removed from the rich solvent. Most preferably, sulfur free lean solvent is regenerated in a distillation column and / or refinery unit, and light components are recycled from the rich hydrocarbon liquid to the absorber.

The invention discloses a synthesis method of aryl-aryl, aryl-alkyl and alkyl-alkyl asymmetric persulfides as shown in a formula (II) or a formula (IV). According to the synthesis method, with sulfinic acid sodium salt, and halogenated hydrocarbon and Na2S2O3 as reaction materials or Bunte salt as a reaction material instead of the halogenated hydrocarbon and Na2S2O3, the aryl-aryl, aryl-alkyl and alkyl-alkyl asymmetric persulfides are obtained by reaction in the absence of transition metal. The synthesis method has the advantages that the reaction is efficient; the yield is high; a vulcanizing reagent is cheap, easily available, stable, and free of pungent smell; no strong acid or alkali or extra oxidizing or reducing agent is added in reaction; the condition is relatively mild; and no transition metal is used as a catalyst in the reaction, and therefore the method is economical, practical and friendly to the environment; a reaction substrate is easy to prepare; the reaction efficiency is high after the reaction is amplified, and therefore, the synthesis method has a wide application prospect and practical value.

The invention provides a preparation method of dicyclohexyl disulphide without harm for environment. Sodium disulfide and chlorocyclohexane react by hydrosolvent to obtain dicyclohexyl disulphide, insoluble is exhausted from the mixture, and separates oil layer and leaves a part of or whole of water layer for the reaction of sodium disulfide and chlorocyclohexane.

The invention discloses a cystamine diisocyanate monomer, cystamine diisocyanate monomer based polymers as well as a preparation method and an application of the cystamine diisocyanate monomer. The cystamine diisocyanate monomer contains a reductive breakable disulfide bond, and the chemical structural formula is shown in the specification; the cystamine diisocyanate monomer can produce linear reductive degradable polyurethane or polyuria through polycondensation with a dihydroxyl compound or a diamino compound, can also produce a reticulated reductive degradable polyurethane through polycondensation with a trihydroxyl compound and can be taken as a coupling agent to connect two polymers with different structures for preparation of a reductive sensitive block polymer. The reductive degradable polymers synthesized from cystamine diisocyanate and containing the disulfide bond can be applied to drug-delivery carriers.

The invention relates to a preparation process of ajoene, comprising the steps of: converting natural alliin or synthesized alliin into allicin in a water solution by utilizing alliinase in garlic, adding a water-soluble organic solvent, such as alcohol, ketone, ether and the like, to remove partial impurities so as to prepare an allicin solution, then adding a dehydrating agent for moderate dehydration, converting 90% of allicin into the ajoene at moderate temperature, and evaporating the solvent to obtain an ajoene product with the purity of 90%. The process is easy to operate and is suitable to scale preparation of the ajoene products.

The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.

Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure:and pharmaceutically acceptable salts, solvates and prodrugs thereof, whereineach R and R′ pair are independently selected from (i) or (ii);(i) R and R′ are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or(ii) R and R′ together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure;X is hydrogen, or an alkyl; and Y is O or S.

The invention discloses a method for hydrolyzing feather to extract amino acid through microwave heating at high temperature and high pressure, which belongs to the amino acid manufacture field; According to the invention, feather and ultrapure water are taken as raw materials, no catalyst is used, a microwave high pressure ceramic reaction vessel is taken as a device, the reaction is carried out at the condition that the temperature is 160-200 DEG C, the pressure is 0.3-1.7MPa and the reaction time is 1 / 6-1 hour, and a mixed liquor of arginine, glycine, proline, aspartic acid, cystine and the like can be obtained after reacting. The production method has the advantages that no soda acid is used, the cost is greatly reduced, no pollution is generated, the reaction time is short; the destroy rate of amino acid in a filtrate is reduced, the process of filtrate post-treatment is simple, the output rate is increased; the production technology is simple, the reaction condition is mild, and the production method has the characteristics of high efficiency and environmental protection.

The invention discloses a trifluoromethylthio reagent as well as a synthetic method and application thereof and provides a compound I and a preparation method of the compound I. The preparation method comprises the step: reacting a compound 1a with trifluoromethylthio silver, so as to obtain the compound 1, wherein the reaction is as shown in the specification. The invention further provides application of the compound 1 as the trifluoromethylthio reagent. The compound 1 can react with amine compounds, thiol or phenolic compounds to generate the compound containing trifluoromethylthio. The trifluoromethylthio reagent 1 has the beneficial effects of high efficiency, conversion rate and yield, mild reaction conditions, low production cost and wide applicable range and is applicable to industrial production.

The invention discloses a method for continuously producing dimethyl disulfide. The method is characterized in that after being molten, a material sulfur is fed into a dimethyl trisulfide reactor by virtue of a feeding pump so as to react with recycled dimethyl disulfide to generate dimethyl trisulfide; dimethyl trisulfide and methyl mercaptan are feed into a dimethyl disulfide reactor so as to react to generate dimethyl disulfide; a dimethyl disulfide crude product is fed into a separating tank, so that most of hydrogen sulfide is separated out, a liquid-phase product is fed into a rectifying tower, a dimethyl disulfide product is condensed and recycled at a tower top, hydrogen sulfide is exhausted as a non-condensable gas, and the dimethyl disulfide and dimethyl trisulfide in a tower kettle are returned and recycled. A method of enabling dimethyl trisulfide to be excessive is adopted, so that methyl mercaptan is completely converted, separating requirements are lowered and a separating process is simplified, and therefore, not only can the dimethyl disulfide yield be improved to 90%, but also the product purity is up to 99wt%.

The invention relates to a method for preparing dibenzyl disulfide. The innovation points of the invention are that: water is taken as a reaction solvent; Na2S2, benzyl chloride and a catalyst are mixed and then react; the reaction temperature is between 30 and 50 DEG; the reaction time is between 10 and 40 minutes; the temperature of a reaction liquid is cooled to 20 DEG C after the reaction is finished; the pH value is adjusted to 7; and a separated organic phase is washed, dried and purified to obtain the dibenzyl disulfide. The method uses trioctylmethylammonium chloride as the catalyst to perform a catalytic reaction on the mixed Na2S2 and benzyl chloride, and has high yield of finished products which is improved by 15 to 20 percent compared with the prior synthetic method; and the method greatly reduces reaction time and reaction temperature, is easy to control reaction process, has few byproducts, and reduces the consumption of energy sources.

The invention relates to a high base number (TBN300) sulfuration alkylphenol calcium and a preparation method thereof; the chemical structural formula of the sulfuration alkylphenol calcium is shown at right, and alkyl phenolic compound, shielding phenolic compound, calcium oxide and / or calcium hydroxide and sulfur are put into a system containing solvent and diluent oil to have sulfuration / neutralization reaction to generate phenate intermediate; carbon dioxide is pumped into the system to have carbonatation reaction; alkyl polylol is added to take part in the reaction when the sulfuration / neutralization reaction is carried out, or the alkyl polylol is respectively added to take part in the reactions when the sulfuration / neutralization reaction and the carbonatation reaction are carried out; long chain carboxylic acid is added to take part in the reaction when the sulfuration / neutralization reaction or the carbonatation reaction is carried out, or the long chain carboxylic acid is respectively added to take part in the reactions when the sulfuration / neutralization reaction and the carbonatation reaction are carried out; the products are refined to prepare the finished goods. The sulfuration alkylphenol calcium is characterized by high base number, low viscosity and precipitation number, good heat storage stability, and the like; as having excellent cleanliness, hydrolysis invariability, alkali retentivity and good inoxidability, the sulfuration alkylphenol calcium causes no environmental protection problem when in use, and belongs to environment-friendly products; as one-step technique is adopted, the reactions are moderate, and filtration is easy.

The invention relates to a method for preparing a rubber auxiliary agent, and particularly discloses a method for preparing rubber peptizer 2,2-dibenzoylamino diphenyl disulphide (DBD). The method for preparing the rubber peptizer DBD is characterized by comprising the following steps of: performing ring opening reaction on benzothiazole to obtain a ring opening product; oxidizing the ring opening product to prepare diphenylamine disulphide; and performing acylation reaction on the diphenylamine disulphide and benzoyl chloride to generate the DBD. According to the method for preparing the rubber peptizer DBD, compared with the conventional process, the product cost is remarkably reduced; the method is favorable for popularization and application of the environmentally-friendly peptizer DBD, and simultaneously breaks through the situation that the product depends on import for a long term; the organic solvent is used as a reaction medium and can be recycled, so little three-waste is discharged; and the production flow is simple and easily controlled, high-temperature and high-pressure reaction does not exist in the method, the equipment investment is low, and the method is easy for production and operation.

One exemplary embodiment can be a process for oxidizing one or more thiol compounds from an alkaline stream. The process may include passing a mixed stream having the alkaline stream to an oxidation vessel having a body and a neck. Often, the body contains one or more packing elements and the neck contains a packing, a distributor, and a mesh. The process can further include passing an oxidized alkaline stream to a separation vessel containing a first chamber and a second chamber. Usually, the first chamber contains a coated mesh.

The invention relates to a method for preparing a rubber peptizing agent, namely a 2,2'-dibenzamido diphenyl disulfide compound. The method comprises the following steps of: putting diphenyl disulfide, a deacid reagent, namely triethylamine, and a solvent in a reactor, stirring at room temperature, and slowly dropping benzoyl chloride, wherein the reaction time is 15-30 min; and obtaining the product by filtering, washing and drying after reacting. The mol ratio of the diphenyl disulfide to the deacid reagent to the benzoyl chloride to diethyl ether is (1.0-1.2):(2.0-2.2):(2.0-2.4):(50-70). According to the method disclosed by the invention, the nitrochlorobenzene is used as a raw material; the diphenyl disulfide is synthesized; the reaction speed is rapid; the reaction process is simple;and the purity of the obtained product is high.

The invention relates to preparation and application of polymerizable disulfide capable of reducing volume shrinkage. The synthesis comprises the following steps: adding aliphatic sulfhydrate with reactive hydrogen and sodium iodide into a reactor, adding hydrogen peroxide dropwise under the condition of magnetic stirring and reacting to obtain a product A; and putting the product A and organic alkali into a reaction bottle and adding an acyl chloride compound dropwise under the action of magnetic stirring to obtain the polymerizable disulfide. The preparation and the application of the polymerizable disulfide capable of reducing volume shrinkage have the following beneficial effects: (1) the polymerizable disulfide can obviously reduce the volume shrinkage in the photopolymerization process and provides a new method for reducing volume shrinkage; and (2) the polymerizable disulfide can take part in photopolymerization and also can initiate photopolymerization.