10results about "Hydropoly/poly sulfide preparation" patented technology

The application discloses a kind of ultrafast metal-free and solvent-free preparation method for preparing symmetric and asymmetric disulfide, which comprises the following steps: at room temperature, raw material R-SH, R'-SH and oxidant and base are added to reaction bottle, shake rapidly for 10-30 seconds, and R-S-S-R' is prepared after the reaction product is purified;Wherein R in R-SH is aliphatic or aromatic group, R' in R'-SH is aliphatic or aromatic group;R in R-SH and R' in R'-SH are same or different;The aromatic group has substituent or no substituent, and the aliphatic is straight chain or has branch;The oxidant is chloroform, and the base is N, N-diisopropylethylamine (DIPEA).The method is simple in operation, high in yield (60-99%), ultrafast in reaction kinetics, greatly improves production efficiency, wide in applicability, avoids the use of organic reaction solvent, raw material is cheap and easy to obtain, and does not contain residual metal and other sticky contaminants from reagent and ligand, provides a safer and more effective method for the synthesis and production of symmetric and asymmetric disulfide-containing compounds.

This invention relates to a polymerizable disulfide, its preparation method, and its uses, belonging to the fields of polymer chemistry and photopolymerization. It is proposed based on the significant volume shrinkage inherent in LED free radical photopolymerization. The beneficial effects of this invention are that the disclosed polymerizable disulfide compound can reduce the volume shrinkage of 405nm LED light-induced free radical photopolymerization, while also possessing initiation and polymerization properties. Furthermore, this disulfide can improve the heat resistance of photocurable materials, showing great application potential in the field of LED photopolymerization.

The invention provides a methyl mercaptan oxidation catalyst and a preparation method thereof, and the method comprises the following steps: treating attapulgite powder with a strong alkali solution, and roasting to obtain purified attapulgite powder; preparing an active metal precursor solution, wherein active metal comprises alkaline earth metal, cerium and rare earth metal; dipping the purified attapulgite powder in an active metal precursor solution, and roasting to obtain catalyst powder; and mixing the catalyst powder with a binder, shaping, and carrying out secondary roasting to obtain the methyl mercaptan oxidation catalyst. The methyl mercaptan oxidation catalyst provided by the invention can effectively catalyze and oxidize methyl mercaptan to produce dimethyl disulfide, and is high in catalytic efficiency and high in product yield; meanwhile, the catalyst disclosed by the invention has certain water resistance, and can prevent moisture in feed gas from influencing the yield of dimethyl disulfide.

The application discloses a method for preparing a biomacromolecule drug delivery carrier based on a simple and efficient interface crosslinking system. The method comprises the following steps: preparing an amphiphilic polymer monomer containing an epoxy group by means of RAFT polymerization, so that the amphiphilic polymer monomer can exist on an oil-water interface; and preparing a three-arm crosslinking agent which is environment-sensitive and is terminated by an amino group; the amino group on the crosslinking agent and the epoxy group on the amphiphilic monomer are crosslinked on the oil-water interface to form a drug delivery carrier. The carrier can encapsulate biomacromolecules, accurately targets tumors through a high permeability and long retention effect, and the glutathione rich in a tumor microenvironment can break the disulfide bond in the carrier to release the encapsulated drugs, thereby achieving the purpose of treating tumors. Therefore, the application provides a drug delivery carrier which is simple and efficient in encapsulating biomacromolecules and high in stability, and the prepared carrier can be efficiently taken by tumor cells and further regulate tumor cell apoptosis, and is high in safety.

The present invention provides a novel naphthalene compound, a synthesis method for said naphthalene compound, and a composition containing said naphthalene compound. This composition can be employed in coating materials, inks, adhesives, pressure sensitive adhesives, gas barrier films, color filters, optical films, optical lenses, and touch panels. The present invention pertains to a naphthalene compound represented by chemical formula (I), a synthesis method therefor, and a composition containing said naphthalene compound. (In formula (I), the R1 groups (i) are the same or different and are each a group represented by formula (1), (ii) are the same and are each a group represented by formula (2), or (iii) are the same and are each a group represented by formula (3).) (In the formulas, Y1 is the same and represents a single bond or a C1-10 alkylene group.)

Provided is a polythiol composition containing a polythiol component (A) that is at least one selected from the group consisting of polythiol compounds represented by formula (A) and a thioamide component (B) that is at least one selected from the group consisting of thioamide compounds represented by formula (B). The peak area ratio [thioamide component (B) / polythiol component (A)] measured by high-performance liquid chromatography is 3 area% or less. In formula (A) and formula (B), R1 represents a C1-30 (m+n)-valent organic group, and n and m each independently represent an integer of 1-8.

The application provides a preparation method of a disulfide pre-sulfurizing agent and application of an amino acid in the method. The amino acid is used as a catalyst, and the disulfide pre-sulfurizing agent with a yield not less than 95% and controllable molecular size can be prepared under normal temperature in an oxygen or air atmosphere. The reaction condition is more moderate, the energy consumption is smaller, the physical hazard is weaker, the health and environmental hazards are lower, and the method is beneficial to the use safety of equipment and prolongs the service life of the equipment in the pre-sulfurization process of a hydrogen sulfide agent.

This invention discloses a heatstroke monitoring and early warning patch based on polyacetylene material. The patch includes a color-changing composite material layer, which is coated, impregnated or compounded with acetylene pigment monomers on the functional areas of a polymer substrate material. Under ultraviolet light, it undergoes in-situ topological chemical polymerization to form an irreversible thermochromic polyacetylene material. After being heated, the patch undergoes multi-step color changes at different temperature critical points, realizing full-process body temperature monitoring from normal body temperature to fever.

A polythiol composition that can improve the pot life of polymerizable compositions. [Solution] A polythiol composition comprising polythiol A2, which is at least one of the polythiols represented by formulas (6) to (8), as the main component, and containing 0.04 to 1.50% of compound (NA2) obtained by replacing at least one mercapto group in component A2 with formula (N1). JPEG2026090356000016.jpg70157

This invention provides aminolipids, lipid nanoparticles, and their uses. The aminolipids have a structure represented by general formula (I), or isomers thereof, pharmaceutically acceptable salts, prodrugs, or solvates. This invention further provides lipid nanoparticles containing these aminolipids. In this invention, an aminolipid having the structure represented by general formula (I) is used as an ionizable lipid compound and obtained LNP by self-assembling with a steroid, a neutral lipid, and a polymer-bound lipid. These LNPs improve the intracellular translational expression level of the supported nucleic acid, enhance the action of nucleic acid-LNP formulations, and provide a theoretical basis for personalized therapy with nucleic acid-LNP formulations. TIFF2026516582000075.tif28170