186results about "Hydropoly/poly sulfide preparation" patented technology

The invention provides novel ionizable lipid as well as a preparation method and application thereof. The structural formula is shown as a formula (I). The ionizable lipid compound contains urea and a bioisostere structure thereof, the encapsulation effect of the ionizable lipid is improved through hydrogen bonds formed by squaramide, urea and thiourea structures and nucleic acid, and the immunogenicity of the ionizable lipid is reduced. The nanoparticles prepared from the ionizable lipid are high in encapsulation efficiency, low in PDI and wide and stable in process adaptability. # imgabs0 #

The invention discloses a Cu (I)-Cys nano material of a bionic plant ethylene receptor protein, an MXene / Cu (I)-Cys nano composite material obtained by compounding the Cu (I)-Cys nano material with MXene, and preparation and application of the MXene / Cu (I)-Cys nano composite material for a wearable sensor, and belongs to the technical field of ethylene sensors. The Cu (I)-Cys nano material provided by the invention is a copper ion-cysteine dimeric complex and is obtained by dimerization of L-cysteine through sulfydryl and chelating of copper ions, and a coordination compound (Cu (I)-Cys) of Cu < + > and L-cysteine can be obtained by regulating the molar ratio of the copper ions to cysteine to be 0.8: 4. The material provided by the invention simulates plant ethylene receptor protein, is low in cost, simple to prepare and high in biocompatibility, can be applied to ethylene room temperature detection, and realizes that the lowest detection concentration reaches 50ppb and the lowest detection limit is 0.043 ppm.

The present invention provides an amino lipid, and lipid nanoparticles (LNPs) and a use thereof, the amino lipid having a structure represented by general formula (I), or an isomer, pharmaceutically acceptable salt, prodrug or solvate of the amino lipid. The present invention further provides LNPs containing the amino lipid. According to the present invention, the amino lipid having a structure represented by general formula (I) is used as an ionizable lipid compound, and the LNPs are obtained by means of self-assembly of the ionizable lipid compound, a steroid, a neutral lipid, and a polymer-bonded lipid. The LNPs can further improve the translation expression level of a nucleic acid load in cells, improve the effect of a nucleic acid-LNP preparation, and enable the nucleic acid-LNP preparation to provide a theoretical basis for personalized treatment.

The invention discloses an unsaturated phenyl ether monomer, a holographic recording medium, a preparation method and a related device, the structural general formula of the monomer is as shown in G1 and G2, R1 represents any one of R2, A1 and A2 independently represent any one of hydrogen and phenyl, A3 represents hydrogen or methyl, A4 represents C1-C4 alkyl or phenyl, n is a positive integer and n = 1-5. The unsaturated phenyl ether monomer provided by the invention has high refractive index and is in a liquid state, and the holographic recording medium with high sensitivity, high diffraction efficiency and high refractive index modulation degree can be obtained by applying the unsaturated phenyl ether monomer to preparation of the photopolymer type holographic recording medium.

A method for producing a polythiol composition, the method including a reaction step of reacting a thiocarbamate resin with a quaternary ammonium salt comprising a quaternary ammonium cation and a counter anion to produce a polythiol composition.

The present disclosure pertains to: an ester compound that is a transesterification reactant between a polyol and a dicarboxylic acid ester having a disulfide bond and that has, in a molecule chain, a disulfide bond and has, at a terminal, a hydroxy group; a method for synthesizing said ester compound; and a resin composition containing said ester compound and a photo-radical generator.

The invention belongs to the technical field of production of rubber vulcanizing agents, and particularly relates to a production method of a rubber vulcanizing agent poly (p-tert-butylphenol disulfide). The production method comprises the following steps: putting p-tert-butylphenol and n-heptane into a reaction kettle, introducing nitrogen for replacement, and stirring and heating to 80-100 DEG C; then stopping introducing nitrogen, pumping disulfur dichloride into the reaction kettle through a feeding distributor, stirring and reacting for 2-3 hours at the temperature of 80-100 DEG C, and introducing nitrogen again for replacement after the reaction is finished; then stopping introducing the nitrogen and carrying out reduced pressure distillation; and finally, introducing nitrogen into the reaction kettle to recover normal pressure, and granulating under the condition of continuously introducing nitrogen to obtain the rubber vulcanizing agent poly (p-tert-butylphenol) disulfide. The production method is safe and efficient, the prepared rubber vulcanizing agent is high in sulfur content and yield, and the solvent loss rate in the production process is low.

The invention discloses a preparation method of an Elobixibat intermediate 2, 4-dibromo-5-methoxybenzene sulfonyl chloride (I), and belongs to the field of preparation of drug intermediates. The method comprises the following steps: oxidizing 3-methoxythiophenol serving as a raw material with hydrogen peroxide to generate a compound II, halogenating the compound II with bromine to generate a compound III, and finally oxidizing and chlorinating with zirconium chloride and hydrogen peroxide to generate the compound 2, 4-dibromo-5-methoxybenzenesulfonyl chloride (I). The preparation method of the intermediate compound III has the advantages of stable property, high yield, high purity, good product appearance, simple post-treatment, suitability for industrial production and the like.

The invention discloses an asymmetric disulfide reagent (R1O-SS-SO2R2) as shown in a formula (3) and a synthesis method thereof, R1O-SS-OR1 as shown in a formula (1) and hyposulfonic acid as shown in a formula (2) are taken as reaction raw materials, no catalyst additive is needed, and the asymmetric disulfide reagent (R1O-SS-SO2R2) compound is obtained through reaction. The method has the advantages of mild reaction conditions, cheap and easily available raw materials, simple reaction operation, high yield, no need of any catalyst additive in the reaction, economy, practicability and environmental friendliness; reaction substrates are easy to prepare; the reaction efficiency is high after reaction amplification. The asymmetric disulfide reagent (R1O-SS-SO2R2) provided by the invention can be used for preparing an asymmetric polysulfide compound. The invention also discloses an asymmetric polysulfide compound synthesized by using the asymmetric disulfide reagent (R1O-SS-SO2R2) as shown in the formula (3) and a synthesis method of the asymmetric polysulfide compound. The method has wide application prospect and practical value.

The present invention belongs to the field of pharmaceutical chemistry technology, and specifically relates to an ionizable lipid compound derived from triglycerides, a preparation method thereof, a drug delivery carrier and an application thereof. The chemical structural formula of the ionizable lipid compound derived from triglycerides is shown in formula (I): Formula (I). The ionizable lipid compound has the advantages of high degradability, high safety, and being conducive to the release of the carried nucleic acid drug. The drug delivery carrier containing the compound has excellent properties such as good in vivo targeting, high biological safety, and high mRNA expression efficiency. The target organs and tissues of the drug delivery carrier containing the compound include tumors, heart, liver, spleen, lungs, kidneys, etc.

The present disclosure relates to a method for oxidation of mercaptans, comprising the following steps: contacting mercaptan compounds with a catalyst for oxidation reaction in the presence of oxygen; the catalyst is a composite catalytic material, which comprises a full-silica molecular sieve and a metal element M dispersed in the intracrystalline of the full-silica molecular sieve; the metal M is selected from one or more of manganese, iron, cobalt, nickel, palladium, platinum, copper and gold. The present disclosure uses a metal-containing hierarchical porous molecular sieve for mercaptan oxidation and dehydrogenation reaction, without adding additional alkali, high conversion rate and disulfide selectivity can be obtained at a lower temperature, which has high industrial application value.

The invention discloses an amphiphilic disulfide and a preparation method and application thereof, and belongs to the technical field of emulsion polymerization, the disulfide has the following structural general formula (I), in the formula (I), R1 is C1-C6 straight chain or branched chain alkyl; r2 is C2-C6 straight chain or branched chain alkyl; M1 is alkali metal ion or NH4 < + >; and M2 is alkali metal ion. A redox system formed by the disulfide and an oxidizing agent is used for post-treatment of a polymerized emulsion, residual monomers and free radicals in the emulsion can be efficiently cleared in a targeted mode, excellent emulsion stability is kept, and formaldehyde is not released.

The invention discloses a method for preparing a biomacromolecular drug delivery carrier based on a simple and efficient interface cross-linking system. An amphiphilic polymer monomer containing an epoxy group is prepared through RAFT polymerization so that the amphiphilic polymer monomer can exist on an oil-water interface, meanwhile, a three-arm cross-linking agent which has environmental sensitivity and is terminated by an amino group is prepared, and the amino group on the cross-linking agent and the epoxy group on the amphiphilic monomer are subjected to a cross-linking reaction on the oil-water interface; a drug delivery vehicle is formed. The carrier can entrap biomacromolecules and accurately target tumors through a high-permeability long-retention effect, and glutathione rich in a tumor microenvironment can break disulfide bonds in the carrier and release drugs entrapped in the carrier, so that the aim of treating the tumors is fulfilled. Therefore, the invention provides a drug delivery carrier which is simple, convenient, efficient in entrapment of biomacromolecules and high in stability, and the prepared carrier can be efficiently taken by tumor cells so as to regulate and control apoptosis of the tumor cells and is high in safety.

This invention discloses a method for synthesizing disulfide ether compounds using visible light-emitting two-dimensional olefin nanomaterials in synergistic catalysis. The method involves mixing a thiol-containing compound with a suitable solvent, and then, under mild light conditions in the presence of a catalytic amount of two-dimensional olefin nanomaterials, achieving efficient disulfide bond construction to obtain a series of disulfide ether compounds. This invention enables the efficient synthesis of disulfide ether compounds. The catalyst used is simple to synthesize, requires low dosage, and is inexpensive. It achieves efficient conversion under mild light conditions, reducing reaction costs and simplifying post-processing steps. The synthesis reaction in this invention can be carried out at room temperature and pressure without any additional additives, exhibiting mild conditions, rapid reaction, and high yield.

The invention discloses a method for synthesizing a dithio alkyl ketone compound by using diisopropylamine, which is characterized in that diisopropylamine is used as alkali, a cycloalkyl peroxy alcohol compound and a tetrasulfide compound are driven by illumination to generate a free radical coupling reaction, and the dithio alkyl ketone compound is successfully synthesized. The preparation method provided by the invention has the advantages of easily available raw materials and simple operation, has excellent functional group compatibility, can meet the synthesis requirements of target products with different structures, and has significant practical application value.

The present invention relates to a colloidal quantum dot material, which comprises colloidal quantum dots and a colloidal quantum dot ligand, and the colloidal quantum dots are encapsulated within the colloidal quantum dot ligand. The colloidal quantum dot ligand has the following structural formula (I). On the one hand, the colloidal quantum dot ligand with this structure can help the colloidal quantum dots disperse in solution, thereby realizing solution processing. On the other hand, after the colloidal quantum dot material forms a film, the colloidal quantum dot ligand can be decomposed into a short-chain structure through a simple annealing process, thus eliminating the traditional multiple ligand exchange and elution processes. The array of colloidal quantum dot photodetectors prepared based on the technical solution of the present invention has an ideal external quantum efficiency.

The present disclosure relates to a novel ionizable lipid containing a biodegradable disulfide bond. The ionizable lipid containing a disulfide bond, according to the present disclosure, stably delivers an anionic drug when prepared into lipid nanoparticles and exhibits an excellent effect, in particular, in delivering nucleic acids, and thus can be effectively used in related technical fields such as lipid nanoparticle-mediated gene therapy.

The invention relates to a compound as well as a synthesis method and application thereof. The invention provides a compound as shown in a formula 9 and a preparation method of a stereoisomer, a tautomer, a hydrate and a solvate of the compound, the structure of the compound has an electron-donating group, the hydrolysis of the compound can be inhibited, and the compound can be used for being combined with dNTP to form a reversible terminator and is used for nucleic acid sequencing. The synthesis method is high in atom economy, simple and convenient to operate, low in cost and easy to operate, greatly enriches the selection range of reaction substrates, can realize higher synthesis efficiency, and is beneficial to further modification and application of methyl-2-(1-(methyldisulfonyl) ethyl) benzoate derivatives. # imgabs0 #

The present invention provides a method for producing a compound (1), the method comprising the following step 1a:　step 1a for reacting a compound (3) and a compound (4) in a two-phase system containing an organic base, an inorganic base, water, and a water-insoluble organic solvent, thereby obtaining the compound (1). The definitions of the symbols in the formula are as described in the description.

The invention relates to a method for the co-production of alkyl mercaptan and dialkyl disulfide, comprising the following successive steps:a) reacting a C1-C4 alcohol in the presence of hydrogen sulfide (H2S) to form a stream (M) comprising an alkyl mercaptan, water, and possibly unreacted hydrogen sulfide, b) purifying the stream (M) to obtain a stream (N) enriched in alkyl mercaptan, c) recovering a first portion of the stream (N) comprising alkyl mercaptan purified in step b), d) sulfur oxidation of the second portion of the stream (N) of alkyl mercaptan in order to form a stream (O) comprising a dialkyl disulfide, hydrogen sulfide, and possibly unreacted alkyl mercaptan, e) purifying the stream (O) to separate, on the one hand, the enriched dialkyl disulfide and on the other hand the hydrogen sulfide and the alkyl mercaptan possibly having not reacted in step d), f) recycling the hydrogen sulfide and possibly the alkyl mercaptan isolated in step e) to the stream (M) obtained in step a), g) recovering the dialkyl disulfide isolated in step e).

A method for producing a polythiol composition, said method comprising: a preparation step for preparing a crude polythiol composition, which is a polythiol composition before purification; and a purification step for obtaining a polythiol composition by purifying the crude polythiol composition with a solvent X containing an alkylene glycol.

This invention relates to the field of sulfurizing agent preparation technology, and discloses an organic sulfurizing agent and its stepwise preparation method and application. The method includes: dissolving a first sulfur in a solvent to obtain a mixed sulfurized oil; contacting the mixed sulfurized oil with a second sulfur, olefin oil, and a solid catalyst under primary heating and reflux; then contacting the resulting mixture I with an optional additive under secondary heating and reflux, wherein the temperature of the primary heating and reflux is lower than the temperature of the secondary heating and reflux; distilling the resulting mixture II; and then separating the solid-liquid mixture to obtain the liquid phase as the organic sulfurizing agent; or, after separating the solid-liquid mixture II, distilling the resulting liquid mixture to obtain the heavy fraction as the organic sulfurizing agent. This method eliminates the need for hydrogen sulfide, and the resulting organic sulfurizing agent has a higher sulfur content, up to 65% by weight. Preferably, no hydrogen sulfide is released during the preparation process, making it more environmentally friendly.

The application discloses a hydrogenation catalyst vulcanizing agent and a preparation method and application thereof. The hydrogenation catalyst vulcanizing agent is an organic polysulfide, the organic polysulfide is calcined at 100 DEG C-280 DEG C under a hydrogen atmosphere, and the weight loss of the hydrogenation catalyst vulcanizing agent is as follows: 25-40% at 100 DEG C-180 DEG C, 20-35% at greater than 180 DEG C to less than 215 DEG C, and 20-30% at 215 DEG C-270 DEG C, with the total weight of the hydrogenation catalyst vulcanizing agent as the basis. The preparation method of the hydrogenation catalyst vulcanizing agent mainly comprises the following steps: reacting elemental sulfur and unsaturated hydrocarbons in the presence of alkaline substances and C8 or above aliphatic hydrocarbons, and obtaining the hydrogenation catalyst vulcanizing agent through separation after the reaction is completed. The hydrogenation catalyst vulcanizing agent not only has a simple preparation method and is easy to control, but also can slowly decompose and release hydrogen sulfide in a hydrogen atmosphere.

The present application pertains to a method of making carbon disulfide. The method comprises reacting methane and sulfur under conditions sufficient to produce carbon disulfide, hydrogen disulfide, and heat. At least a portion of the produced hydrogen disulfide is reacted with methane under conditions sufficient to produce a mixture comprising carbon disulfide and hydrogen. Advantageously, at least a portion of the heat from reacting methane and sulfur is employed in the reacting of at least a portion of the produced hydrogen disulfide with methane.

The present invention belongs to the technical field of chemical synthesis and discloses a 14 The aminoacetylation of sodium C acetate is applied to a solvent by adding sodium C acetate, amine, and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / EDCI in a one-pot method to obtain the desired acetamide; wherein, based on the molar mass ratio of the sodium C acetate: amine: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / EDCI = 1:0.5-3:0.5-5; the solvent is acetonitrile and water in a volume ratio of 1:0.5-5.

The application discloses a kind of ultrafast metal-free and solvent-free preparation method for preparing symmetric and asymmetric disulfide, which comprises the following steps: at room temperature, raw material R-SH, R'-SH and oxidant and base are added to reaction bottle, shake rapidly for 10-30 seconds, and R-S-S-R' is prepared after the reaction product is purified;Wherein R in R-SH is aliphatic or aromatic group, R' in R'-SH is aliphatic or aromatic group;R in R-SH and R' in R'-SH are same or different;The aromatic group has substituent or no substituent, and the aliphatic is straight chain or has branch;The oxidant is chloroform, and the base is N, N-diisopropylethylamine (DIPEA).The method is simple in operation, high in yield (60-99%), ultrafast in reaction kinetics, greatly improves production efficiency, wide in applicability, avoids the use of organic reaction solvent, raw material is cheap and easy to obtain, and does not contain residual metal and other sticky contaminants from reagent and ligand, provides a safer and more effective method for the synthesis and production of symmetric and asymmetric disulfide-containing compounds.

The invention discloses a method for catalytically synthesizing sulfurized isobutylene, which is used for preparing high-yield and high-purity sulfurized isobutylene in a mild synthesis mode under the combined action of ultrasound and a catalyst. The method comprises the following steps: mixing tert-butyl mercaptan and sulfur, and carrying out ultrasonic dispersion treatment to obtain a dispersion system; under the ultrasonic action, adding a catalyst into the dispersion system for reaction; the catalyst is aluminum oxide modified by ZnO and ZrO2; and after the reaction is finished, filtering the reaction system, separating out the catalyst, and carrying out reduced pressure distillation to obtain sulfurized isobutylene.

The present invention belongs to the field of preparation methods of aliphatic disulfides, and particularly relates to a method for catalytic synthesis of symmetrical dialkyl disulfides, which is implemented according to the following steps: (1) Place a magnetic stirrer bar, measured thiol, sulfur, and an organic superbase catalyst into a reaction flask; (2) Place the reaction flask in an oil bath of a magnetic heating stirrer, install a condenser, and connect the condenser to a drainage bottle through a silicone rubber tube. A saturated aqueous solution of H<subgt;2< / subgt;S is pre-added to the drainage bottle; (3) Start heating and begin stirring the reaction, start timing, and determine the amount of H<subgt;2< / subgt;S released and the reaction termination time by the drainage method to obtain the target product. The reaction conditions of the present invention are mild, the reaction rate is fast, the atomic utilization rate and the yield are high, and the by-product H<subgt;2< / subgt;S gas is easily separated and utilized.

The invention belongs to the technical field of chemical synthesis, and discloses an asymmetric disulfide compound containing a sulfoxide group as well as a preparation method and application thereof, and the asymmetric disulfide compound containing the sulfoxide group has a structure as shown in a structural general formula (I). By improving the structure of the compound and the preparation method thereof, the obtained compound as shown in the structural general formula (I) is novel in structure and stable in property; the preparation method has the advantages of cheap and easily available raw materials, simple operation, high reaction yield, convenient separation and purification of intermediates and products, suitableness for industrial production, and high preparation efficiency. Moreover, the compound as shown in the structural general formula (I) can be particularly used as an activating reagent to be applied to glycosylation reaction, is simple and convenient to operate and high in reaction activity when being used for glycosylation reaction, and can be widely applied to activation of thioglycoside and selenoglycoside to construct various substrates such as oxygen glycoside, phenolic glycoside, ester glycoside, nucleoside and carbon glycoside.

A method for producing a polythiol composition including a reaction step of reacting a thiourethane resin and a nitrogen-containing compound that is at least one selected from the group consisting of a quaternary ammonium salt and an amine compound in the presence of water to generate a polythiol composition.