47 results about "Organic reaction" patented technology

The invention relates to preparation of a crystalline allyl covalent organic framework material and application research of the crystalline allyl covalent organic framework material in benzamide cyclization green photocatalytic conversion. The SF-COF material is prepared by adopting a step-by-step synthesis method. The preparation method comprises the following steps: synthesizing a COF precursor by taking 1, 3-benzenetricarboxaldehyde and p-aminophenylacetonitrile as raw materials, and preparing the allylation covalent organic framework material with the electronic push-pull effect from the COF precursor and 5, 5 ', 5'-(benzene-1, 3, 5-triyl) tri (thiophene-2-formaldehyde) through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and benzamide cyclization and conversion of derivatives of benzamide are achieved under irradiation of a blue light LED. The prepared SF-COF has the advantages of efficient charge separation and electron conduction performance, good structural stability and chemical stability and the like. And a catalyzed organic reaction substrate has the advantages of wide universality range, good cycle stability and the like, and shows excellent photocatalytic conversion capability.

The invention provides a 1, 4-diaza-butanetriene compound as well as a synthesis method and application thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: carrying out a first reaction on a compound 1 and a compound 2 in a solvent A, removing the solvent A after the reaction is finished, extracting with benzene or toluene, filtering, mixing with 12-crown ether-4, and stirring to obtain a compound 3; the synthesis method of the compound 3 provided by the invention is high in yield, simple to operate, mild in reaction, simple in required reaction condition control and high in speed. The obtained compound 3 has excellent stability and can be used for key intermediates in various organic reactions, such as preparation of alpha-diimine ligands.

The present application belongs to the technical field of heat dissipation devices, and particularly relates to a double-sided heat-conducting gasket with different properties and a preparation method thereof. The present application does not use the existing silica cloth as a reinforcing material, but uses a glass cloth blank without additional material and without a coating process as a medium for supporting two kinds of silica gel. The concentration of organic reactants and the molecular weight of silica gel on both sides of the glass cloth are calculated and controlled, and then the silica gel is subjected to stepwise calendering and vulcanization, so as to form a double-sided heat-conducting gasket with different properties on both sides, one side having adhesion and no air holes, and the other side having high strength and less oil bleeding. The present application firstly reduces the oil bleeding rate on the surface of the gasket with the traditional silica cloth as the reinforcing material, and secondly effectively reduces the dense air holes on the surface of the high-heat-conducting gasket with the additional reinforcing material below 0.5 mm, thereby enhancing the stability of the gasket performance.

The disclosure discloses a cyclodextrin glycosyltransferase with enhanced solvent tolerance and preparation thereof, belonging to the technical fields of enzyme engineering and genetic engineering. The disclosure constructs four cyclodextrin glycosyltransferase mutants with enhanced organic solvent tolerance. Among them, the mutant with the optimal tolerance to DMSO and methanol is G539I / R146F / D147N, which is 1.6 times and 1.7 times higher than that of WT, respectively; the mutant with the optimal tolerance to ethanol is R146F, which is 1.4 times higher than that of WT; the mutant with the optimal tolerance to acetone is G539I / R146F, which is 1.5 times higher than that of WT. The disclosure helps to expand the application of glycosyltransferases in organic reaction systems, improves the enzymatic efficiency of CGTase on natural hydrophobic substrates, and has great application prospects.

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

This invention provides a class of general-purpose chiral catalysts containing a cinchona primary amine arylformamide skeleton, along with their preparation methods and applications, belonging to the field of catalytic materials technology. The chiral catalysts provided by this invention link cinchona primary amine with oxazole / thiazole / imidazolium formamide structural units capable of coordination. Through the coordination of the oxazole / thiazole / imidazolium and amide coordinating groups with the central metal, they act as chiral ligands to catalyze a wider range of asymmetric reactions. They can also be used alone as chiral small-molecule catalysts for cinchona-like tertiary amine (thiourea) and square amides to catalyze asymmetric organic reactions. Furthermore, they can achieve synergistic (co-catalytic) catalysis of small molecules and metals in the same reaction system through different combinations. These chiral catalysts can be widely used as Lewis bases, Lewis acids, or small-molecule chiral catalysts and chiral ligands, possessing potential scientific and applied value in chiral sciences such as asymmetric catalysis, chiral synthesis, and chiral resolution.

A preparation method and use of a novel pure inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material are disclosed. The surface hydroxyl-rich metasilicic acid is used as the raw material, and by using a sulfonating reagent and / or phosphoric acid, the sulfonic acid group and / or the phosphoric acid group are bonded to the inorganic silicon material by chemical bonding to obtain a pure inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material. The catalytic material can be widely used in many acid-catalyzed organic reactions such as isomerization, esterification, alkylation, hydroamination of olefins, condensation, nitration, etherification, multi-component reactions and oxidation reactions. The inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material of the present invention has the advantages of high acid amount, high activity, good hydrothermal stability, no swelling, simple preparation, low cost, no pollution, no corrosion, easy separation and reusability.

The application discloses a kind of ultrafast metal-free and solvent-free preparation method for preparing symmetric and asymmetric disulfide, which comprises the following steps: at room temperature, raw material R-SH, R'-SH and oxidant and base are added to reaction bottle, shake rapidly for 10-30 seconds, and R-S-S-R' is prepared after the reaction product is purified;Wherein R in R-SH is aliphatic or aromatic group, R' in R'-SH is aliphatic or aromatic group;R in R-SH and R' in R'-SH are same or different;The aromatic group has substituent or no substituent, and the aliphatic is straight chain or has branch;The oxidant is chloroform, and the base is N, N-diisopropylethylamine (DIPEA).The method is simple in operation, high in yield (60-99%), ultrafast in reaction kinetics, greatly improves production efficiency, wide in applicability, avoids the use of organic reaction solvent, raw material is cheap and easy to obtain, and does not contain residual metal and other sticky contaminants from reagent and ligand, provides a safer and more effective method for the synthesis and production of symmetric and asymmetric disulfide-containing compounds.

The invention belongs to the technical field of electrocatalytic materials, and particularly relates to an electrocatalyst with a saturated coordination zinc diatom structure, a preparation method and application. Based on the principle that the boiling point of zinc chloride is lower than that of cadmium chloride and the boiling point of elemental cadmium is lower than that of elemental zinc, ZIF-8 serves as a precursor and is heated together with cadmium chloride, Zn in ZIF-8 can be volatilized at high temperature, Zn in ZIF-8 is replaced by cadmium chloride in the high-temperature process, cadmium (II) is reduced into elemental cadmium (Cd) steam by carbon generated by pyrolysis, and the elemental cadmium (Cd) steam leaves a reaction system; and finally, the catalyst (Zn DACs / N-C) with an excellent ORR performance and a zinc diatom structure is synthesized, and is expected to become a catalyst in fuel cell cathode reaction, automobile exhaust removal and organic reaction.

The invention discloses a mitochondrial targeting pyridinium cyanine photosensitizer compound, a preparation method, a compound and application thereof, and the pyridinium cyanine photosensitizer compound is generated through organic reaction by taking N-methyl-N-hydroxyethyl naphthylamine as an electron donor, pyridinium cyanine as an electron acceptor and double bonds as pi bridge connection. After the pyridycyanine photosensitizer compound is self-assembled and combined with HSA, specific fluorescent staining of mitochondria is achieved, active oxygen is efficiently generated under white light irradiation and directly acts on the mitochondria, and the cancer cell killing efficiency is improved. The preparation method is simple and efficient, and the prepared photosensitizer compound has a good photodynamic therapy effect and biological safety and has a good application prospect.

The invention relates to the field of organic synthesis, in particular to a post-treatment method for a catalytic hydrogenation reaction by using a copper-containing catalyst, which comprises the steps of adding an auxiliary agent and standing. According to the method, separation of the copper-containing catalyst and the organic reaction system is promoted in an efficient, economical, simple and convenient manner, on one hand, the purity and stability of catalytic hydrogenation products are improved, on the other hand, more copper-containing catalysts can be recycled, and generation of heavy metal waste is reduced.

Gold(I) complexes capable of absorbing light in the near-UV and / or visible region, and methods of making and using the same, are described. These gold(I) complexes have photochemical reactivity, such as strong absorption of near-UV and / or visible light, quenching rate constants of > 3.5 x 10 5 s ‑1 This enables them to catalyze photoredox reactions under near-UV and / or visible light, such as homocoupling of organic halides (e.g., alkyl halides and aryl halides), alkylation of 2-phenyl-1,2,3,4-tetrahydroisoquinolines, cyclization of indoles, reductive dehalogenation of aryl halides, and / or C-H bond cleavage, among others. The yields of products of photo-induced organic reactions catalyzed by the gold(I) complexes described herein can be higher than the yields of the same products formed from the same reactions under the same reaction conditions using [Au2(μ-dppm)2](Cl)2, [Ru(bpy)3](Cl)2, and / or [fac-Ir(ppy)3] at the same or higher loading than the loading of the one or more gold(I) complexes.

The invention discloses a liquid-phase organic reaction apparent dynamics modeling method based on a reaction calorimetry, and belongs to the technical field of chemical reaction engineering, and the method comprises the following steps: S10, obtaining a real-time reaction heat release rate in a reaction process, carrying out noise reduction processing on original heat flow data through a data smoothing algorithm, and obtaining concentration data of each component after each group of reaction is finished; s20, analyzing a reaction mechanism and a reaction path according to a reaction type, reaction conditions and reaction process characteristics; establishing a reaction kinetics ordinary differential equation set according to the target reaction formula; and S30, performing global search in the parameter space by taking the genetic algorithm as an optimization framework main body so as to search a parameter combination enabling the target function to be optimal, and obtaining a final optimization result. According to the method, accurate apparent kinetic parameters are obtained, and a model prediction result is highly matched with experimental data, so that a reliable theoretical basis is provided for reaction process optimization, amplification and safety control.

This invention provides a mononuclear manganese complex containing acetylacetone and β-ketoimine ligands, and a method for its preparation. This invention synthesizes a novel mononuclear divalent manganese complex Mn. II (acac)2(Hki)2. This compound is readily soluble in a variety of organic solvents, exhibits good stability, and is not easily deliquescent, making it an ideal source of divalent manganese. This invention employs a solution method to synthesize the aforementioned mononuclear divalent manganese complex, utilizing inexpensive and readily available raw materials; the reaction conditions are mild and can be carried out at room temperature; only water is used as the solvent, making it environmentally friendly; the reaction product is singular, easily purified, and yields the target compound in high quantities. This invention also synthesizes a novel mononuclear trivalent manganese complex, Mn. III (acac)2(ki), which differs from manganese acetylacetonate (III) in that one acetylacetonate anion is replaced by a ⁻-ketoimine anion. Mn III (acac)2(ki) is soluble in a variety of organic solvents and is an ideal trivalent manganese source reagent for anhydrous organic reactions.

The present invention relates to the field of organic synthesis and more specifically it concerns a process for purifying an organic reaction product from a crude product mixture.

This invention relates to a bis-Sydney ketone terminal compound, its preparation method, and its application, belonging to the field of organic synthesis technology. It solves the problems of existing synthetic methods involving multiple reaction steps, low reaction efficiency, low yield, and difficulty in efficiently and massively synthesizing bis-Sydney ketone terminal compounds. The preparation method synthesizes the bis-Sydney ketone terminal compound through a three-step organic reaction, including the following steps: Step 1: Dissolving a primary amino compound, a secondary amination reagent, and a base in a solvent to undergo a secondary amination reaction, followed by recrystallization to obtain a first intermediate; Step 2: Dissolving the first intermediate, adding a hydrolysis reagent to undergo a hydrolysis reaction, adjusting the solution to acidity, and filtering to obtain a second intermediate; Step 3: Dissolving the second intermediate, adding a nitrosating reagent to undergo a nitrosation reaction, adding a dehydrating agent to the reaction system to undergo an internal cyclization reaction, and post-treatment to obtain the bis-Sydney ketone terminal compound.

The application belongs to the technical field of chemical synthesis, and discloses a microfluidic droplet-Raman combined two-phase reaction synthesis system screening chip system and method, which is composed of a microfluidic droplet two-phase reaction chip and a droplet bearing chip, and the microfluidic droplet two-phase reaction chip comprises four solution adding areas, two droplet generating areas, two droplet mixing areas, a droplet balancing area, a droplet fusion area and corresponding sample inlets and outlets; the droplet balancing area connects all parts in the chip, balances pressure, and enables the droplets to reach and fuse simultaneously; the fused droplets reciprocate in the mixing reaction area, the reagents in the droplets are mixed and two-phase interfacial reactions occur; the reaction droplets are guided out of the chip outlet, added dropwise to the droplet bearing chip, and further combined with external Raman spectrum detection. The droplet bearing chip comprises a droplet bearing micropit array, the overall size is adapted to the Raman spectrum carrier table, and a precise control and high-throughput screening method is provided for screening two-phase organic reaction paths.

The application relates to the technical field of lithium ion battery materials, and specifically discloses a modified lithium titanium aluminum phosphate material, a preparation method and application thereof. The material comprises a lithium titanium aluminum phosphate material with a chemical formula of Li 1+X Al X Ti 2‑X (PO4)3, wherein the x satisfies 0.3 <= x <= 0.5, the modified lithium titanium aluminum phosphate material is prepared by preparing a lithium titanium aluminum phosphate matrix from a mixture containing a lithium source, an aluminum source, a titanium source, a phosphorus source and an organic reaction medium, and then treating the lithium titanium aluminum phosphate matrix in a sulfur dioxide-containing atmosphere; and the organic reaction medium contains a salicylic acid derivative and a nitrogen-containing compound. The method combines the process of organic reaction medium-assisted gas phase transmission and controllable sintering in a sulfur dioxide atmosphere, effectively solves the problems of uneven element distribution and large grain boundary resistance, and the modified lithium titanium aluminum phosphate material can be used in lithium ion batteries to significantly improve the rate performance and cycle stability of the batteries.

The invention discloses a helicene bisphosphite ligand as shown in a formula 1, a preparation method of the helicene bisphosphite ligand, a nickel-based catalyst containing the helicene bisphosphite ligand and a preparation method of the nickel-based catalyst. The ligand compound can be used as a ligand of a homogeneous metal catalyst, and can be used in organic reactions such as hydrocyanation reactions of olefins. A catalyst prepared from the helicene bisphosphite ligand is used for preparing nitrile substances, not only is high in catalytic activity, high in yield and high in stability, but also is high in product position selectivity, so that a linear addition product of anti-Markov addition can be obtained more easily, and the helicene bisphosphite ligand has a wide industrial application prospect. Formula 1

The invention discloses nano silicon dioxide with acid catalysis performance, a preparation method of the nano silicon dioxide and application of the nano silicon dioxide in organic reaction, and belongs to the technical field of catalytic materials, allyldodecyl phosphoric acid grafted and modified nano silicon dioxide spheres are used as an emulsifier and an acid catalyst, and have efficient and recoverable catalysis performance. The nano silicon dioxide spheres are modified into the composite material with acidic groups, so that the composite material can show excellent catalytic effects in a plurality of organic reactions, including Knoevenagel condensation reaction, esterification reaction, acylation reaction and the like. The catalyst system can also catalyze in a solvent-free or green solvent system, has excellent stability and reusability, meets the requirements of green chemistry and environmental protection, and has wide industrial application prospects.

The invention discloses a biological hydrogen production method, which relates to the technical field of biological energy, and comprises the following steps: S1, under the condition of no illumination, anaerobic bacteria and an organic reaction solution are subjected to a reaction to prepare hydrogen and dark fermentation tail liquid; s2, the dark fermentation tail liquid enters a photoreactor, photosynthetic bacteria are added, and hydrogen is prepared; wherein the photosynthetic bacteria are loaded on the composite carrier, and the specific loading method comprises the following steps: pretreating vermiculite, then soaking the vermiculite in a bacteria solution containing the photosynthetic bacteria for continuous culture, and taking out the vermiculite after the culture is finished. The photosynthetic bacteria are loaded on the composite carrier through a dark-light combined biological hydrogen production process, so that on one hand, strains can be concentrated to realize immobilization and the treatment efficiency of the strains can be improved, and on the other hand, the light absorption rate of the photosynthetic bacteria can be further improved by adding the light guide particles on the composite carrier, so that the photosynthetic bacteria can be effectively degraded. The strain treatment efficiency is further improved.

This disclosure relates to a process for producing alkyllithium compounds for use as anionic polymerization initiators, as well as in various organic reactions. More particularly, it relates to a process for producing an alkyllithium solution by reacting lithium metal having a specific surface area of from 1 to 100 cm2 / g with an alkyl halide in an organic solvent medium under conditions of high turbulence, wherein the molar ratio of lithium metal to alkyl halide is from 2.5:1 to 5.5:1. The technical result achieved by the present disclosure includes in achieving a high yield of alkyllithium using lithium metal having a low specific surface area under conditions of high turbulence and at a molar ratio of lithium metal to alkyl halide of from 2.5:1 to 5.5:1, which is comparable to the alkyllithium yield achieved using finely dispersed lithium metal particles having a high specific surface area.

The application discloses a liquid-core waveguide light reactor and a liquid-core waveguide light irradiation method. The light transmission satisfies the total reflection condition by setting the included angle between the light and the channel wall, and the light is transmitted by multiple total reflections in the medium in the channel as the light guide medium, so that the light guide method similar to the optical fiber is realized. The liquid-core waveguide light irradiation method repeatedly passes the light in the longitudinal direction through the inner channel multiple times, can keep strong and uniform light irradiation in the flow light reactor with a length of several centimeters, and improves the effective light irradiation length of the photocatalytic organic reaction sample in the channel. The liquid-core waveguide light irradiation method is favorable for shortening the time consumption of the photocatalytic organic reaction, efficiently and quickly completing the reaction, reducing the loss of the light caused by refraction, scattering and absorption, significantly improving the light utilization rate, and meeting the development demand of green chemistry.

The invention provides a multi-chiral-center non-biaryl organosilicone atropisomer and a preparation method and application thereof, and the structural formula of the multi-chiral-center non-biaryl organosilicone atropisomer is as shown in formula (I), the synthesis method of the multi-chiral-center non-biaryl organosilicone atropisomer specifically comprises the following steps: in the presence of a phosphine ligand, a nickel catalyst and a reaction medium, carrying out silicon-carbon bond activation on non-biaryl aldehyde and benzo silacyclobutane to carry out ring expansion reaction. According to the present invention, the reaction condition is mild, the operation is simple, the substrate universality is strong, the crude product is subjected to rapid column chromatography impurity removal, vacuum concentration is performed to obtain the pure product, the post-treatment is convenient, the finally obtained product has high stereoselectivity, and the non-biaryl organosilicon atropisomer contains a plurality of functional groups and a plurality of chiral centers, has potential biological activity, and can be used for the preparation of the non-biaryl organosilicon atropisomer. The compound can be used as a fine chemical intermediate to be widely applied to various organic reactions and drug synthesis, and has considerable application value.

The invention discloses a Pickering emulsion with pH responsiveness as well as a preparation method and interface catalysis application of the Pickering emulsion, and belongs to the technical field of functional nano materials and interface catalysis. The preparation method comprises the following steps: synthesizing nickel-doped carbon dot (Ni-CDs) nanoparticles in one step through a solvothermal method; carrying out amino functional modification on the nickel-doped carbon dots to prepare an amphiphilic carbon dot emulsifier with a pH response characteristic; the emulsifier is added into an oil-water two-phase system, so that a stable Pickering emulsion is formed. The Pickering emulsion can construct a stable catalytic microenvironment on an oil-water interface, is used for an interface catalysis process of an organic reaction, and remarkably improves the reactant mass transfer efficiency and the catalytic reaction efficiency; after the reaction is finished, controllable demulsification of the emulsion and catalyst recovery can be realized by adjusting the pH value of the system, and cyclic utilization of the catalyst is realized. The preparation method disclosed by the invention is simple, green and environment-friendly, and the obtained emulsion has good interface catalytic performance and recoverability and has good application and popularization values.

The present invention addresses the problem of providing: a solid acid catalyst having improved reaction efficiency and liquid permeability; and an organic reaction method using the solid acid catalyst. In order to solve the problem, the present invention provides a solid acid catalyst comprising a sulfo group-modified porous body that contains a porous body having a bicontinuous structure formed by macropores (2) and a ceramic framework (1) including mesopores (3), and a sulfo group that modifies the surface of the ceramic framework (1). The mode pore diameter of the macropores of the sulfo group-modified porous body is 200.0-5000.0 nm.

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

The invention relates to the field of food preservatives, and discloses a food preservative as well as a preparation method and application thereof. The main component of the food preservative is (+)-catechin-3-O-myristate, and the (+)-catechin-3-O-myristate is obtained by carrying out organic reaction on (+)-catechin and myristic acid and esterifying myristic acid and (+)-catechin C ring No.3 hydroxyl. The (+)-catechin-3-O-myristate overcomes the problem that natural (+)-catechin has a poor inhibition effect on gram-negative bacteria, plays an excellent effect in food preservation, and can significantly inhibit the reproduction of microorganisms in food storage and slow down the process of food spoilage.

The application discloses a synthesis method of deuterium-substituted olefin by using D2O as a deuterium source and a palladium membrane for catalysis, and belongs to the technical field of synthesis of deuterium-substituted olefin blocks. The application uses a three-chamber electrolytic cell separated by a palladium membrane and an ion exchange membrane as a reactor, uses the palladium membrane as a working electrode, uses a deuterium water solution as an electrolyte, electrolyzes the deuterium water by using a constant potential electrolysis method, transmits active deuterium formed to an organic reaction side using anhydrous ethanol or cyclohexane as an organic solvent, and then synthesizes deuterium-substituted olefin compounds by using a palladium membrane modified by sodium benzene thiol for catalyzing reduction and deuterization of acetylene compounds with high selectivity, so as to further synthesize corresponding deuterium-substituted drugs. The application provides a green, efficient, high-universality and low-cost amplification synthesis method for synthesizing deuterium-substituted olefin blocks containing easily-reduced and easily-hydrolyzed functional groups, and has a wide application prospect.

The application belongs to the field of catalytic chemistry, and particularly relates to a 1,10-phenanthroline ligand derivative, and preparation and application thereof. The application provides a derivative of a 1,10-phenanthroline ligand as shown in formula (I) with an amide group introduced at positions 2 and 9. The 1,10-phenanthroline ligand derivative with an amide group introduced at positions 2 and 9 can enhance metal coordination ability, optimize chelation stability with metals, and can be used as a high-efficiency metal catalyst ligand to catalyze organic reactions. The 1,10-phenanthroline ligand derivative can form stable metal coordination with transition metals such as iron, cobalt and nickel, and can efficiently catalyze trifluoromethylation reaction, Ullmann type etherification reaction and polymeric ester polymerization in cooperation with copper and zirconium alkoxide.