36 results about "Biological substances" patented technology

An aseptic containment chamber defines a containment volume for the handling and / or processing of chemical-pharmaceutical-biological substances and comprises a lighting system with adjustable colour temperature; the lighting system comprises a lighting body having at least one LED source configured to emit at least one beam of warm light and / or a beam of cool light of adjustable intensity and directed towards the inside of the containment volume and at least one unit for the adjustment and / or partialisation of the current in relation to the voltage and / or intensity for adjusting the emission of the beam of warm and / or cool light from the LED source.

Provided herein is a biological substance treatment method in which a flow cell is prepared, the flow cell including a chamber array device including a plurality of chambers and a cover body defining a flow path communicating with an opening of the plurality of chambers and provided in common for the plurality of chambers.

The capsule module for multi-collection of intestinal biological substances according to the present invention can collect intestinal samples in various places within the gastrointestinal tract by means of the administration of a single capsule without the aid of an external system and thus can improve the accessibility and convenience of intestinal microorganism research.

A compound having two or more phosphor parts having mutually equivalent light absorption characteristics, wherein adjacent phosphor parts are connected via a group including a structure represented by general formula (I), and a labeled biological substance using the compound. In the formula, X1 to X3 represent-O-,-S-, > NR1, or > CR2R3. And each of R1-R3 and R11 represents a hydrogen atom or a substituent. And R8 represents a hydrogen atom or a substituent. And n is an integer of 2 or more. And * represents a connecting bond.

A compound containing two or more phosphor moieties, in which each of the phosphor moieties adjacent to each other is linked by a linking group having a Molecular Flexibility of 0.510 or less and a cLogP of 6.0 or less, and a labeled biological substance using the compound.

The invention discloses a preparation method of a material for enriching hydrophilic biological substances, which is characterized in that peptide fragments are enriched through specific binding of chemically modified magnetic nanoparticles and glycosylated peptide fragments, so that the problems of high cost, complicated operation and limited identification flux are solved; and an efficient, stable and easy-to-operate technical process is provided for research on glycoproteomics. The surface of the magnetic bead is a combination of a mesoporous structure and a quaternary ammonium salt group, so that the selectivity on a glycosylated peptide fragment is remarkably improved, and non-specific adsorption is reduced. The number of N-glycopeptides can be averagely identified to 2733, and the number of O-glycopeptides can be averagely identified to 1777. The enrichment process is simplified by introducing the magnetic beads, and subsequent automatic experiments and large-scale application are facilitated. And the cost is reduced: the preparation and application cost of the material is reduced by simplifying the synthesis method and improving the stability of the material.

A medical centrifuge temperature calibration device relates to the technical field of medical instruments, and comprises a box body, a temperature detection assembly, a refrigeration system and a heating element, the temperature detection assembly is arranged in a working chamber to detect the temperature in the working chamber, the temperature is fed back to a control unit, and the control unit is used for controlling refrigeration to the refrigeration system to reduce the temperature. According to the centrifugal machine, the control unit sends the control instruction to the heating element to heat so as to increase the temperature in the working chamber, so that the temperature in the centrifugal machine is accurately corrected, the requirement for detecting the temperature is met, the centrifugal machine can provide a cultivation environment with the stable temperature, and the use requirement for separation of different biological substances is met.

The invention relates to the technical field of medical instrument recycling, in particular to an operating room nursing instrument recycling device capable of avoiding cross infection. Comprising a moving trolley, a waste liquid box, a liquid storage box, a controller, a storage box, sliding frames, connecting rods and the like, the waste liquid box is connected to the moving trolley, the liquid storage box is connected to the top of the waste liquid box, the controller is installed on the side face of the liquid storage box, the storage box is connected to the top of the waste liquid box and located on the front side of the liquid storage box, and the sliding frames are slidably connected into the storage box at intervals; round holes are symmetrically formed in the two sides of the sliding frame, and the connecting rod is connected to the inner wall of the sliding frame. By arranging the infusion mechanism and the U-shaped spray pipe, used surgical instruments can be automatically sprayed and washed immediately after an operation, blood and other biological substances on the surfaces of the instruments are removed in time through a cleaning agent, solidification of the substances is effectively prevented, the subsequent cleanliness of the surgical instruments can be ensured, and the cross infection risk is avoided.

There is provided a particle for the immunoagglutination assay that is a particle for immunoagglutination assay, which includes a diamond particle and a ligand that specifically binds to a biological substance. The ligand is immobilized to the diamond particle, and the particle for the immunoagglutination assay has a particle size of 50 nm or more and 1,000 nm or less.

Provided is a biological sample analysis device that prevents a container containing a sample from being charged and can accurately measure only the intensity of light emitted from the sample. The biological sample analysis device (100) is used for rapid inspection of microorganisms by analyzing light generated by a substance originating from a biological body contained in the sample. The biological sample analysis device (100) comprises a plurality of containers (2) containing the sample, a light detector (4) fixed at a predetermined position, a support driving mechanism (5) that drives the support (3) and sequentially positions each container (2) held by the support (3) to a detection position by the light detector (4), and a static eliminator (NE) that removes static electricity from the container (2) held by the support (3).

A biological substance cumulative amount measurement device 1 for measuring a cumulative amount of a biological substance generated in a living body, said device including: a biofuel cell 20 for generating power using a specific biological substance 13 as a substrate; a power storage unit 40 for storing electric energy generated through power generation by the biofuel cell 20; and a communication unit 50 for outputting information on the electric energy stored in the power storage unit 40 in response to a trigger from the outside.

A membrane capsule for biological and chemical separations comprising a cassette comprising an upper surface and a lower surface adjoined by a cassette sidewall, an inlet and an outlet located on the upper and lower surfaces of the cassette, tubes fluidly connected to the inlet and the outlet, holes or slots in the tubes to facilitate separation, and a membrane wrapped, pleated, and / or spiral wound around each of the tubes. Methods of separation comprising flowing fluid flow through the inlet of the membrane capsule, allowing the fluid to permeate through the holes or slots of the tubes, separating biological and / or non-biological substances, collecting the fluid within a reservoir, and draining fluid from the reservoir.

This biological substance aspiration catheter 1 includes: a catheter body part 10 having an internal lumen 11; and a hollow tip part 20 provided at a tip portion of the catheter body part 10. The hollow tip part 20 includes: a tip-end opening 21 which communicates with the internal lumen 11; a tapered part 22 which is reduced in diameter toward the tip end; and a side port 23 which is provided in the tapered part 22 and communicates with the internal lumen 11. The side port 23 includes: a starting end 24 which is positioned nearer the rear end than the tip part of the tapered part 22 and the tip-end opening 21; and a terminal end 25 which is positioned on the rear end part side of the tapered part 22 or the hollow tip part 20. The side port 23 extends in the axis direction of the hollow tip part 20.

The excitation light source (1) emits excitation light that advances in the optical medium (3) toward the sample (5) placed on the sample placement surface. The probe light source (2) emits probe light advancing in the optical medium (3). The light position detector (4) detects the position of the emitted probe light emitted from the optical medium (3). The arithmetic unit (11) calculates the position of the probe light emitted by the light position detector (4) when the sample (5) is a reference substance that absorbs the excitation light and does not have a specific absorption peak within the excitation wavelength of the excitation light, and the position of the probe light emitted by the light position detector (4) when the sample (5) is a biological substance. The amount or concentration of the biological component in the biological substance is calculated.

The invention relates to the technical field of veterinary drugs, in particular to a composition for preventing and / or treating donkey mastitis and application thereof. The invention provides a composition for preventing and / or treating donkey mastitis. The composition comprises the following components: nisin, lysozyme, a honeysuckle extract, a dandelion extract, a lithospermum extract, an astragalus extract and a frankincense extract. The composition can effectively prevent and / or treat donkey mastitis, the active ingredients of the composition are natural or biogenic substances, the antibacterial mechanism of the composition is unique, bacteria are not easily induced to generate drug resistance, and the composition is safe and free of residues, meets the urgent needs of green, healthy and sustainable development of animal husbandry, and has remarkable clinical application value and wide market prospects.

The invention discloses a metabolite-disease association prediction method, and belongs to the technical field of bioinformatics. According to the method, a metabolite-disease-gene multi-source fusion heterogeneous network is constructed by using metabolite omics information, not only is the relationship among different biological substances considered, but also the problem of matrix sparsity is solved, and a local-global feature extraction model LGDFE is proposed, so that the method has the advantages of being high in robustness and high in robustness. The deep relationship in the multi-source fusion heterogeneous network is extracted from global and local angles, the problem that the deep relationship between metabolites and diseases is difficult to fully excavate in a traditional method is effectively solved, the deep learning algorithm CNN is used for predicting data, features of different levels can be automatically fused, the parameter complexity of a common classifier is reduced, and the classification efficiency is improved. The unknown correlation between the metabolite and the disease can be predicted, the prediction efficiency is improved, the correlation between the metabolite and the disease does not need to be obtained through a large number of experiments, and the experiment cost is remarkably reduced.

To solve ethical and sanitary problems in a simulated thrombus and to improve the elasticity of the simulated thrombus.SOLUTION: The simulated thrombus includes a gel-like blood portion containing simulated blood made of a non-biological substance as a main component, and graphite powder contained in the blood portion.SELECTED DRAWING: Figure 3

The invention discloses a biological substance separation device and a separation method thereof, and relates to the technical field of substance separation. The device comprises a supporting bottom frame, a separating mechanism is fixedly installed at the top end of one side of the supporting bottom frame, a pressure stabilizing mechanism used in cooperation with the separating mechanism is arranged at the top of an inner cavity of the separating mechanism, and a material moving mechanism used in cooperation with the separating mechanism is arranged on the other side of the top end of the supporting bottom frame. The separating mechanism is matched with the material moving mechanism for use, so that the two separating filter cartridges can be conveniently and stably clamped, the two separating filter cartridges can be driven to be subjected to up-down position adjustment and rotary displacement, and the two separating filter cartridges can be driven to be independently subjected to turnover adjustment, so that convenient disassembly and assembly and transfer transposition of the separating filter cartridges are realized; therefore, the cleaning operation of the used separation filter cartridge can be synchronously performed while the separation operation of the biological substance solid-liquid mixture is performed, and compared with a traditional integrated separation device, the separation operation does not need to be interrupted for cleaning, so that the separation efficiency is effectively improved.

The barrel 30 of a suction pump 14 of this medical suction device 1 comprises a first valve part 36 that allows inflow of air from a front space 33 in a first ventilation passage 35 to a rear space 34 when a piston 50 moves rearward, and suppresses outflow of air from the rear space 34 to the front space 33 when the piston 50 moves forward. The piston 50 is provided with a second valve part 52 that allows outflow of air from the rear space 34 in a second ventilation passage 51 to the outside when the piston 50 moves forward, and suppresses inflow of air from the outside to the rear space 34 when the piston 50 moves rearward. The suction pump 14 is capable of generating negative pressure for suctioning a biological substance when the piston 50 moves rearward.

A device for measuring electrical conductivity of target ("Target") comprising blood, a body fluid, a body tissue, a biological substance, a liquid or a solid material, comprising a hollow body having a closed end and an open end; a triboelectric nanogenerator (TENG) disposed within the hollow body; the TENG comprising first and second discs disposed within the hollow body, wherein the first disc is disposed adjacent to the closed end of the hollow body and the second disc is spaced apart from the first disc to define a target chamber within the hollow body; a third disc spaced apart from the second disc towards the open end to define a gap between the second and third discs; a first electrode comprising an electrically conductive material disposed on a side of the third disc opposite the gap; and a second electrode comprising a Target in the target chamber.

A device that allows for either fat graft preparation or cell fraction harvest is disclosed. The device includes a first centrifuge tube configured to receive and process a biological substance, the first centrifuge tube comprising an upper cylindrical portion and a lower conical portion, a sterile tissue inlet fitting, at least one sterile processing fluid inlet fitting, a sterile suction fitting, and at least one sterile extraction port connected to a first extraction tube. The first centrifuge tube further includes an internal space including a screen being positioned therein, the screen being configured to divide the internal space in half, and a filter positioned therein, the filter being positioned below the screen in the lower conical portion of the first centrifuge tube. The device may further include a second centrifuge tube configured to receive and further process the biological substance from the first centrifuge tube. The second centrifuge tube has at least one sterile fitting, wherein the second centrifuge tube is releasably connected via the at least one sterile fitting to one of the at least one sterile extraction ports of the first centrifuge tube.

The utility model discloses a monitoring device for an intake salt meter of a hypertensive patient, and relates to the technical field of biological substances such as blood and urine. The monitoring device comprises a display, the right side of the display is fixedly connected with a fixing block, the right side of the fixing block is provided with a storage groove, the left side of the storage groove penetrates through the fixing block, a supporting plate is installed in the storage groove, and the upper side and the lower side of the supporting plate are both semi-cylindrical surfaces. A storage groove is formed in the upper portion of the fixing block, a check block is connected into the storage groove, the left side of the check block is fixedly connected with the displayer, the check block is arranged at the position close to the lower side, the right side of the displayer is fixedly connected with a containing shell, and a control mechanism is arranged in the fixing block. And therefore, the display can be supported and fixed on different objects, and meanwhile, the stability after supporting can be ensured, so that the application range of the device is widened.

The utility model relates to the technical field of video optical transceivers, in particular to a video optical transceiver with a waterproof bottom, which comprises a transceiver body, a connector fixedly connected to the surface of the transceiver body, a mounting plate fixedly connected to the surface of the transceiver body, and a waterproof mechanism arranged on the surface of the transceiver body and comprising a rotating seat. And the rotating seat is fixedly connected to the surface of the machine body, a rotating plate is rotationally connected to the surface of the rotating seat, and a first limiting plate is fixedly connected to the surface of the rotating plate. The surface of the connector is sleeved with the waterproof cylinder, the waterproof cylinder extrudes the sealing ring on the connector, the sealing ring seals the waterproof cylinder and the connector, water is prevented from entering the connector through the waterproof cylinder, bacteria and other biological substances are prevented from being deposited on the unused connector, the sanitary use condition of the connector is guaranteed, and the service life of the connector is prolonged. And joint faults are prevented.

The present invention provides an integrated system built on a microfluidics with multiple layers including a cell culture surface and different chambers configured to allow multiple cultivations of a biological agent, formation of three-dimensional multicellular culture model or biofilm, colonization and re-colonization of the biological agent responsive to a stimuli introduced to the integrated system. Such stimuli include physical, chemical and / or biological substance that may affect proliferation, differentiation, and / or function of the biological agent. The biological agent includes a biofilm-forming microbe such as a ubiquitous biofilm-forming bacterial species or biological cells or tissues of a different origin or species such as eukaryotic cells / tissues. The present integrated system can be used in drug screening, establishment of disease model in vitro or in vivo, evaluation of an anti-microbial efficacy, and studying cell-cell interaction.

The invention discloses a method for detecting false positive by inhibiting antigen-antibody reaction and application thereof. The method comprises the following steps: carrying out treponema pallidum gel agglutination test detection on a to-be-detected sample, screening out a positive sample, mixing the positive sample with a reducing agent, standing, carrying out treponema pallidum gel agglutination test detection again after standing, and calculating an affinity index to judge whether the result is false positive. The invention provides a method for treating a sample by using beta-mercaptoethanol as a reducing agent, which can inhibit antigen-antibody reaction to detect false positive, effectively eliminate false positive results caused by non-specific biological substances and improve the detection accuracy.

The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC™) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.

A compound having two or more phosphor parts, wherein adjacent phosphor parts are linked by a linking group having a molecular flexibility of 0.510 or less and a cLogP of 6.0 or less, and a labeled biological substance using the compound.

To provide a reaction device capable of maintaining the same dispensing amount accuracy of a chemical liquid between a plurality of array plates.SOLUTION: A reaction device for producing a reaction product of a living body-derived material contained in a spot on an array plate and a target material in a sample liquid includes a container placement section on which a reaction container including the array plate is placed, a chemical solution placement section on which a chemical solution container containing a chemical solution is placed, a pipetter to which a pipette tip is attached and which the chemical solution from the chemical solution container and dispenses the chemical solution into the reaction container, and a control section that changes a dispensing operation of the pipetter according to at least any of a type of the chemical solution, a state of the chemical solution, an operation history of the pipetter, and a state of the pipette tip.SELECTED DRAWING: Figure 1

The object of the invention is to provide an improved device for delaying the biological degradation processes of organic materials arranged in a container and a corresponding method. The device according to the invention is designed in such a way that it acts on the interior of a container which serves to hold the organic materials. The device according to the invention comprises at least two of the following components: - a unit for creating a vacuum in the container - a UV radiation emitting unit, - a dewatering unit and / or a drying unit, - a cooling unit,- a fumigation unit for fumigation with germ-inhibiting gases, such as in particular CO2 and / or nitrogen, - a feed unit for adding germ-inhibiting biological substances..

This container structure is mounted on an array plate having an upper surface on which a spot array including a biological substance is formed, and the container structure is configured so as to form a container that has the array plate as the bottom plate thereof and that is capable of storing liquid, wherein the container structure includes: an embankment portion that forms a side wall of the container when mounted on the array plate; and a retroreflective light attenuating portion that is disposed facing to the array plate to reduce retroreflective incidence of light that has passed through the spot array onto the spot array. This reduces the impact of retroreflective light that has passed through the spot and is scattered forward becoming background light noise.