97 results about "Particle fraction" patented technology

The invention provides a formulation to be administered as dry powder for inhalation suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering of pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation freely flowable, which can be produced in a simple way, physically and chemically stable and able of delivering either accurate doses and high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable particle size and to also improve the storage stability of said formulations. To this end, magnesium stearate is used in said formulations. One of the features of the inventive dry powder is that a high fine particle dosage or fine particle fraction can be maintained also under relatively extreme temperature and humidity conditions.

The invention discloses a method for processing laterite-nickel ore. The method provided by the invention is characterized in that laterite-nickel ore undergoes an ore-washing treatment; noumeite and limonite-type laterite-nickel ore are separated; separated noumeite is melted by the pyrometallurgical process to generate ferronickel; and metallic nickel is extracted from the separated limonite-type laterite-nickel ore by the wet process. According to the method provided by the invention, based on the different mineral compositions of different laterite-nickel ore particle fractions, limonite-type laterite-nickel ore containing high content of iron and low content of magnesium is melted by the wet process to extract metallic nickel, thus leading to low acid consumption; noumeite containing low content of iron and high content of magnesium is melted by the pyrometallurgical process to extract ferronickel, thus leading to high quality of the produced ferronickel, high recovery rate of nickel, low energy consumption and simultaneous recovery of iron.

In a semi-permeable membrane system for separating magnetic particle fractions from a mixture contained in a first fluid, comprising a membrane with opposite membrane surfaces between which passages extend and which separates the first fluid from a second fluid each of which is in contact with one of the membrane surfaces, means are provided for generating a reversible pressure differential between the two fluids across the membrane and means for generating and eliminating a magnetic field in the membrane for alternately causing a fluid flow through the membrane in opposite directions wherein, during the fluid flow in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.

The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.

The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable particle size and to also improve the storage stability of said formulations. To this end, magnesium stearate is used in said formulations. On of the features of the inventive dry powder is that a high fine particle dosage or fine particle fraction can be maintained also under relatively extreme temperature and humidity conditions.

A delivery device for a medicament including: a housing, a receptacle holding a medicament in the form of a power; and a source of propellant, wherein the housing provides an inlet and an outlet for the receptacle, wherein the inlet is in fluid communication with the source of propellant and is directed against the medicament and the outlet is spaced from the medicament to allow aerosolization of the medicament; the device provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

A particulate feed comprising a first particle type and a second particle type is separated by providing a separation apparatus having a separation vessel having a top and a bottom, and wherein the separation vessel includes inwardly sloping side walls. A magnet structure has a first pole positioned exterior of and adjacent to each of the side walls of the separation vessel, and a second pole positioned above the separation vessel. A mixture of the particulate feed and a ferrofluid is introduced into the separation vessel, and the particulate feed is separated into a first particle fraction comprising a majority of the first particle type, which sinks in the separation vessel, and a second particle fraction comprising a majority of the second particle type which floats in the separation vessel.

A dry powder inhaler (DPI) device has a flow passage with a three-dimensional (3D) rod array. The rod array includes multiple rows each having multiple unidirectional rods. The rows are spaced apart along a primary direction of air flow and are staggered. A viewing window to the capsule chamber allows viewing of the capsule's position within the chamber which provides visual feedback of inhalation flow rate to the user during inhalation. The capsule chamber may orient the capsule parallel to a primary direction of air flow or perpendicular to a primary direction of air flow and provide capsule motion in a plane which is perpendicular to the primary direction of air flow.

The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the present invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition prepared by freeze-drying a composition liquid containing ingredients in a non-dissolved form, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.05 or more, and (iii) a property of becoming fine particles having a mean particle diameter (mass median aerodynamic diameter) of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising a member capable of applying said air impact to the freeze-dried composition in said vessel, and a member for discharging the powder-form freeze-dried composition that has been made into fine particles.

A sinter mixture granulating method comprises following steps: 1) a blending ore is applied as a granulating raw material; 2) the blending ore is segmented into two parts according to a particle fraction of 3.0-4.0 mm. The blending ore whose particle fraction is less than 3.0-4.0 mm is subjected to a primary and a secondary mixing granulation with other conventional ingredients of preparing a sinter mixture. 3) the particles obtained from the secondary mixing granulation are added into the blending ore having the particle fraction greater than 3.0-4.0 mm obtained by the segmentation before, and subjected to a tertiary mixing granulation. The method can improve granulating effects for the sinter mixture, improve permeability of a material layer in a sintering process, optimize a sintering state and reach an ideal producing technique index finally.

A coated glass product includes a glass substrate and a porous antireflection surface coating including SiO₂-based particles having a first particle fraction including a first characteristic particle size range and a second particle fraction having a second characteristic particle size range that is different from the first characteristic particle size range. In addition, a method for producing the coated glass product is provided.

Eddy current separation apparatus (1) for separating particles (20) from a particle stream (w), wherein the apparatus (1) comprises a separator drum (4) adapted to create a first particle fraction (21) and a second particle fraction (23), a feeding device (2) upstream of the separator drum (4) for supplying particles (20) to said separator drum (4), and a splitter element (14) provided downstream of the separator drum (4) for splitting the respective fractions (21,23), wherein the apparatus (1) further comprises a sensor device (11,111,211) arranged for detecting particles (20), at least a number and/or material properties thereof, from at least part of one of the particle fractions (21), wherein the separation apparatus (1) is configured to adjust, in use, a position and/or orientation of the splitter element (14) with respect to the separator drum (4) and/or a transporting velocity of the feeding device (2) in dependence of a signal from the sensor device (11,111,211) based on the number and/or material properties of the detected particles (20).

The invention discloses a construction method for a two-dimensional discrete element model of a mother rock and a particle material thereof. The construction method comprises three steps of grading curve correction, mother rock test discrete element modeling and particle material discrete element modeling. The step of grading curve correction comprises the sub-step of redistributing the mass of a smallest particle fraction to the remaining particle fractions according to the quality ratio of particles of particle fractions except the particle fraction of a finest stage in a grading curve to obtain a correction simulation curve in a computer operation simulation range and a particle diameter range of basic particle units. The particle material discrete element modeling comprises the sub-step of: firstly, randomly generating a rock area outline; secondly, forming a rock unit from the basic particle units; thirdly, assigning contact attributes in rocks; finally, assigning the contact attributes between the rocks. In rock aggregation generated according to the construction method, good randomness and diversity are available for the particle number and the form of composed rocks and the actual outline of the rocks; the rock size is generated according to a certain grading condition and satisfies the requirement of certain porosities.

A method and system for reducing the un-burned carbon content in coal combustion products are disclosed. A coal combustion product is separated into a coarse particle fraction and a fine particle fraction, and the coarse particles are comminuted by milling, grinding or the like. Additives may be added of the coarse particles prior to comminution. The comminuted particles are then co-combusted with coal to burn at least a portion of the un-burned carbon contained in the original coal combustion product.

An improved atomization system for aerosolizing liquids including a vortexing nozzle and a flat or protruding face on the nozzle exit orifice. The system can also include a diverging mouthpiece insert. The present invention can produce a high fine particle fraction and modest throat deposition in conjunction with reduced aerosol plume velocity and impact force.