97 results about "Particle fraction" patented technology

A new dry powder inhaler is developed as a pulmonary medicine delivery device for dispersing precise tiny dosages (10 μg-50 mg) of pure carrier-free ultra-fine powdered medicament (<5 μm aerodynamics particle size) into a patient's lung. The powder is drawn from the blister cell and dispersed through an outlet tube assisted by two air streams. The first air stream goes through a the blister cell from its upstream side, to significantly fluidize the medicament in the dose to flow upward. The second one extracts the fluidized powder from downstream of the blister cell for further deagglomeration and dispersion of the medicament powder by shear force. The rotating multi-dose blister can hold up to 60 doses, which are pre-metered with pure ultra-fine powdered medicament. So that it has higher drug loading capability in small volumes, compared to most current dry powder inhalers, which usually use some excipient. The inhaler efficiently disperse the aerosolized medicament in the air stream to the deep interior of patient's lung. The fine particle fraction (<4.7 μm) is reported to reach as high as 80% using this inhaler.

A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and / or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

The invention provides a method and tool to perform an analysis of CRUD on a nuclear fuel rod. The method recites providing a nuclear fuel rod with a layer of CRUD on an exterior of the fuel rod, scraping the CRUD from the fuel rod with a CRUD scraping tool and collecting CRUD flakes from the CRUD scraping tool. The method also provides for sorting the CRUD flakes into particle fractions, and analyzing the CRUD with a scanning electron microscope, wherein the scraping tool has a blade with a rigidity that is matched to an anticipated CRUD deposit shear strength.

Disclosed is a magnesia-carbon based sleeve brick for steelmaking converters, which is obtained by adding, to a refractory raw material mix containing 60 to 95 mass % of a magnesia raw material and 5 to 20 mass % of graphite, a metal powder of one or more selected from the group consisting of Al, Si, Mg, Ca, Cr and an alloy thereof, in an amount of greater than 3 to 6 mass %, and an organic binder, in addition to 100 mass % of the refractory raw material mix, and subjecting the resulting mixture to kneading, forming and heat treatment, wherein the sleeve brick is used under a condition that a thickness thereof is set at 70 mm or less. This makes it possible to prevent cracking which would otherwise occur in the sleeve brick itself, to allow the sleeve brick to have enhanced durability. One or more selected from the group consisting of B, B4C, MgB2, CaB6, and CrB may be further added in an amount of 0.1 to 3 mass %, in addition to 100 mass % of the refractory raw material mix, to enhance strength and oxidation resistance and further enhance the durability. The magnesia raw material may comprise a first particle fraction having a particle diameter of greater than 10 to 500 μm and occupying 20 to 50 mass % in the refractory raw material mix, and a second particle fraction having a particle diameter of 10 μm or less and occupying 5 mass % or less in the refractory raw material mix, to additionally enhance corrosion resistance and thermal shock resistance.

A particulate feed comprising a first particle type and a second particle type is separated by providing a separation apparatus having a separation vessel having a top and a bottom, and wherein the separation vessel includes inwardly sloping side walls. A magnet structure has a first pole positioned exterior of and adjacent to each of the side walls of the separation vessel, and a second pole positioned above the separation vessel. A mixture of the particulate feed and a ferrofluid is introduced into the separation vessel, and the particulate feed is separated into a first particle fraction comprising a majority of the first particle type, which sinks in the separation vessel, and a second particle fraction comprising a majority of the second particle type which floats in the separation vessel.