32 results about "Powder Aerosol" patented technology

A single dose disposable powder aerosol device belongs to the field of medical devices. It is composed of a bottom cover, a suction nozzle and a sliding cover. The suction nozzle and the sliding cover are assembled on one side of the bottom cover. The suction nozzle is assembled on the front half of the bottom cover, and the sliding cover is assembled on the rear half of the bottom cover. An air inlet, a medicine pit, a medicine inlet channel and a vortex cavity are sequentially arranged on the bottom cover. At least one side air inlet is arranged on the side of the vortex cavity. An ascending air duct and a medicine outlet are sequentially arranged in the suction nozzle body. After the bottom cover, the suction nozzle and the sliding cover are assembled into one, the air inlet, the medicine pit, the medicine inlet channel, the vortex cavity, the ascending air duct and the medicine outlet form a complete flow channel cavity. The filling operation of the medicine powder in the medicine pit is realized through three steps of sliding the sliding cover, loading the medicine powder and closing the sliding cover. The sliding cover structure is adopted, which is convenient for the filling operation or supplement of the built-in medicine powder, and can be switched between disposable and reusable types. It can be widely used in the design and manufacture field of inhalation type drug delivery devices.

1. The name of the design product: powder aerosol dispenser (inhalation type). 2. The use of the design product: for oral inhalation of powder medicine. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view 1. 5. Design 1 is designated as the basic design.

The invention provides a detection light path for a solid powder dispersing device, and belongs to the technical field of solid powder dispersing devices.The detection light path for the solid powder dispersing device comprises a light emitting assembly, a light path transmission system, a light receiver, a light trap assembly and a detection pipe, and the detection pipe is arranged in an optical detection cavity of the solid powder dispersing device; the detection tube comprises a coaxial tube diluter and a sheath gas protection device, the coaxial tube diluter is used for diluting gas entering the detection tube, and the sheath gas protection device is used for forming annular sheath gas flow, restraining powder aerosol in the center of a light path and preventing powder particles from being deposited on the cavity wall of the detection tube; the invention provides a detection light path for a solid powder dispersing device, which can solve the problem that the accuracy of a detection structure is influenced due to the fact that the concentration of the existing detection gas is too high.

The utility model provides an anti-misoperation structure of a dry powder inhalation dosing device, which relates to the technical field of dry powder inhalation dosing devices, and comprises a main body mechanism, an anti-touch mechanism is arranged on one side of the main body mechanism, the main body mechanism comprises a hollow cavity I, an outer ring is arranged on the outer side of the hollow cavity I, a hollow cavity II is arranged at one end of the outer ring, and an anti-touch mechanism is arranged on the other side of the hollow cavity II. And an inner matching disc is arranged on the inner side of the outer ring. The inner matching disc is rotated, whether the first leading mark corresponds to the second leading mark or not is observed in the rotating process, the discharging port of the material box perpendicularly corresponds to the feeding port when the first leading mark corresponds to the second leading mark, and therefore objects in the material box can enter the second hollow cavity along the path, and the objects can enter the second hollow cavity through rotation of the inner matching disc again. The feeding port does not correspond to the discharging port any more, meanwhile, in the process, due to the fact that the scraping plate is installed at the bottom of the inner distribution disc, objects in the second hollow cavity can be scraped into the containing cavity, and therefore the dosage and the dosage position of the dry powder inhalation can be effectively controlled in the mode.

The invention relates to the technical field of traditional Chinese medicine preparations and atomization medicine delivery, in particular to a method for treating chronic bronchitis based on Tibetan medicine Bunjinjian San, which comprises the following steps: S1, drying Bunjinjian San raw medicine at low temperature, and carrying out superfine grinding to obtain raw medicine micro powder; s2, removing resin and grease impurities; s3, carrying out vacuum concentration on the obtained filtrate; s4, treating the concentrated extract through an ultrafiltration membrane; s5, preparing the clarified extracting solution into atomized liquid; s6, medicine aerosol is formed through ultrasonic oscillation; s7, guiding the chronic bronchitis patient to inhale the drug aerosol; s8, after all the inhalation treatment courses are completed, a treatment conclusion report is obtained. According to the present invention, the particle size controllable Bunjinjian aerosol is prepared through the continuous purification-clarification-sterilization-atomization process, such that the targeted lower respiratory tract drug delivery is achieved, the preparation quality and the equipment smoothness are ensured, the local treatment effect is improved, and the whole body side effect is reduced.

1. The name of the design product: powder aerosol administration device. 2. The use of the design product: for oral inhalation of powder medicine. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view 1. 5. Design 1 is designated as the basic design.

The application discloses an experimental system for analyzing combustion of aluminum powder with different concentrations, and belongs to the field of aluminum powder combustion experiments.The application comprises a multi-element diffusion flat flame burner, an aerosol generator and an optical diagnosis system.The multi-element diffusion flat flame burner and the aerosol generator are placed in a high-pressure bin, and gas paths are connected.The high-pressure bin is closed, combustion gas is introduced from the lower part of the burner, oxidizing gas is introduced from the upper part of the burner, mixing is carried out in a capillary, and the capillary mouth is reached.The multi-element diffusion flat flame burner simulates the high-temperature gas phase environment and component atmosphere in a real combustion device through gas distribution, carries out particle ignition and combustion characteristic test through central supply of aerosol, and has good optical visualization conditions.The aerosol generator is used to generate relatively uniform monodisperse aluminum powder aerosol from a powder generator without using a vibration device.The optical diagnosis system obtains temperature information of combustion through various means, carries out comparison, and increases accuracy of experimental data.

The application discloses a compound inhalation powder aerosol and a preparation method thereof. The compound inhalation powder aerosol comprises apremilast or a pharmaceutically acceptable salt thereof and an efficacy enhancing substance, wherein the efficacy enhancing substance is nintedanib or a pharmaceutically acceptable salt thereof; and the amount of the efficacy enhancing substance is 0.1-10 times the amount of the apremilast or the pharmaceutically acceptable salt thereof. In the compound inhalation powder aerosol, the drug exposure of apremilast is greatly improved under the action of nintedanib, and a significant enhancement effect is exhibited. Meanwhile, nintedanib further improves efficacy. The powder aerosol is used for pulmonary inhalation administration, and apremilast or the pharmaceutically acceptable salt thereof and nintedanib or the pharmaceutically acceptable salt thereof are used for treating lung diseases, so that the drugs can be directly delivered to effective sites, the administration dose can be further effectively reduced or the drug utilization rate can be improved, the deposition rate can be improved, and the treatment effect can be greatly improved.

Provided are a metformin inhalation powder aerosol for treating idiopathic pulmonary fibrosis and a preparation method thereof, including following steps: pretreating a metformin raw material to obtain fine powder, and passing the obtained fine powder through a screen with a mesh size of 100-1000 microns by an pendular granulator at a rotating speed of 200 revolutions per minute to obtain soft particle clusters; pre-spheronizing clusters at a vibration frequency of 100-300 hertz to obtain particle clusters, and then rolling the particle clusters on a granulating pan and spheronizing to obtain spherical particle clusters.

The invention relates to a multi-dose dry powder inhalation inhaler. The multi-dose dry powder inhalation inhaler comprises a suction nozzle; the storage bin comprises a plurality of bin chambers for storing powder; the auxiliary part comprises an air flow channel and a suction channel which are arranged separately, the suction channel is communicated with the suction nozzle, and the air flow channel and the suction channel are used for being communicated with the bin; when the auxiliary part and the bin are in a communicating state, the airflow channel is used for guiding air to enter the bin in the tangential direction, and the suction channel is used for powder in the bin to penetrate through so as to enter the suction nozzle. The storage bin and the auxiliary part move relatively, so that the auxiliary part is switched to be communicated with the next bin from the current bin. According to the multi-dose powder inhalation inhaler, on the basis of achieving multi-dose supply, the powder delivery efficiency can be improved, the overall structure can be simplified, and operation is more convenient and automatic.

The present application relates to a visualization powder aerosol inhalation detection system, which relates to the technical field of dry powder inhalation; it includes a medicine box and a mouth suction tube. A medicine cavity is provided in the medicine box, and the mouth suction tube is inserted into the side wall of the medicine box and used to communicate with the medicine cavity; it further includes a concentration detection module, a control module and a visualization module. The concentration detection module and the visualization module are both communicatively connected to the control module. The concentration detection module is used to detect the concentration information of the powder aerosol in the mouth suction tube, and the control module is used to control the visualization module to feedback the powder aerosol concentration information to the user, so that the user can obtain the powder aerosol concentration information; the present application has the effect of facilitating the user to obtain the inhalation situation of the powder aerosol in real time and reducing the situation that the treatment effect is affected due to insufficient dose of the powder aerosol not fully inhaled by the user.

The present application relates to the technical field of pharmaceutical preparations, in particular to a powder aerosol intermediate composition and a preparation method thereof, a sodium ciprofloxacin inhalation powder aerosol and an application thereof. The raw and auxiliary materials of the intermediate composition include 1-7 wt% of sodium ciprofloxacin, 92-98 wt% of lactose and not more than 1% of magnesium stearate, in terms of mass percentage fraction; the D 50 of the sodium ciprofloxacin is 1-5 microns; the D 50 of the lactose is 100-150 microns. The intermediate composition can be used for preparing the sodium ciprofloxacin inhalation powder aerosol, and can realize efficient delivery of the sodium ciprofloxacin, improve the delivery efficiency of the sodium ciprofloxacin at a target site, and reduce systemic side effects. The sodium ciprofloxacin inhalation powder aerosol can be used for treating mild diseases such as cystic fibrosis, interstitial pneumonia and idiopathic pulmonary fibrosis, and thus expands the indications of the sodium ciprofloxacin.

The invention discloses a powder aerosol state continuous generation powder feeding device which comprises a conveying pipeline, an outlet in the lower portion of the conveying pipeline is connected into an outer cylinder, the lower end of the outer cylinder is provided with a discharging port contracting inwards, a circle of air inlet ring communicating with the interior of the outer cylinder is fixed to the side wall of the outer cylinder, and an air inlet pipe is arranged on the side wall of the air inlet ring; a plurality of vertical air guide plates are distributed on the circumference of the inner wall of the air inlet ring; a fixed cylinder is erected in the outer cylinder through a plurality of fixed plates, the upper part of the fixed cylinder is an upper cone, and a plurality of guide plates are circumferentially distributed between the fixed cylinder below the air inlet ring and the side wall of the outer cylinder; compared with the prior art, the device can continuously and stably convey highly dispersed and non-agglomerated fine ceramic powder aerosol flow.

The present invention discloses a composition for improving depression, its preparation method and application, belonging to the technical field of biomedicine. The composition is a liposome obtained by embedding palmitoyl tripeptide-8 and EUK-134 in a phospholipid bilayer; the mass ratio of palmitoyl tripeptide-8 to EUK-134 is (1-3):(1-3). Palmitoyl tripeptide-8 is added to the stirred phospholipid mixture and mixed evenly to obtain mixture A; EUK-134 is added to water and mixed evenly to obtain solution B; then solution B is slowly injected into mixture A under stirring, and after the injection is completed, stirring is continued, and then high-pressure homogenization treatment is carried out to obtain a liposome suspension, that is, the composition for improving depression. The liposome can be added with medical excipients to be made into nasal drops, sprays, gels, creams, powders or powder aerosols. After nasal absorption, it can effectively improve chronic depression.

A dual-reservoir powder inhaler device belongs to the field of drug delivery devices. A first and a second medicine storage barrel are provided; a first and a second medicine pit are respectively and correspondingly provided below the two medicine storage barrels; a first and a second delivery channel are provided; one ends of the first and second delivery channels respectively correspond to the first and second medicine pits, and the other ends are connected to a dispersion chamber; two drug prescriptions are separately stored in the two medicine storage cylinders, a "rotary disk" type dosing structure is adopted, and they are respectively delivered to the same dispersion chamber through separate medicine pits and separate delivery channels, and then are delivered to the outlet through a nozzle channel; the process of the drugs in the two medicine storage barrels being discharged from the medicine storage barrels, dispensing a single inhalation dose, and then being delivered to the dispersion chamber and then to the outlet is carried out simultaneously to ensure that the drugs of the two doses can be dispersed and delivered to the patient's body at the same time. It can ensure that the two prescription drugs do not interfere with each other during the storage and dosing processes. It can be widely used in the design and manufacturing fields of powder inhaler devices.

The invention provides a dry powder inhalation composition for inhalation, a dry powder inhalation for inhalation, a preparation method of the dry powder inhalation and an inhalation dry powder inhalation, and belongs to the technical field of pharmaceutical preparations. The dry powder inhalation composition comprises a first component and a second component, the first component is corticoid or pharmaceutically acceptable salt or isomer thereof; the second component is a beta2 adrenergic receptor agonist or a pharmaceutically acceptable salt or an isomer of the beta2 adrenergic receptor agonist; the molar ratio of the first component to the second component is (0.1-25): 1. According to the dry powder inhalation composition provided by the invention, the delivery efficiency of the first component and the second component in the dry powder inhalation composition can be higher than the delivery efficiency of a single component of the first component and the delivery efficiency of a single component of the second component, so that the drug effects of corticoid and a beta2 adrenergic receptor stimulant in the dry powder inhalation composition can be fully exerted; the traditional Chinese medicine composition can help patients with lung diseases such as mild and moderate asthma, chronic obstructive pneumonia and the like to relieve respiratory obstruction and has the effect of treating inflammation at the same time.

The present invention relates to a method for producing a coated wall-flow filter. The wall-flow filter is coated with a powder aerosol.

1. The name of the design product: powder aerosol administration device. 2. The use of the design product: for oral inhalation of powder medicine. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The invention relates to a suction type dry powder inhalation administration device which comprises an administration tube, an administration tube and a suction tube, the administration tube comprises a tube body, a sliding plunger is arranged in the tube body, a blade is arranged on the side portion of the plunger, and the blade extends out of the tube body through an axial seam formed in the tube wall of the tube body; the dosing mechanism comprises a shell, a suction nozzle is arranged at the top end of the shell, a dosing tube space used for containing a dosing tube is arranged in the shell, a driving mechanism used for being matched with the blade is arranged on one side of the dosing tube space, and the driving mechanism can drive the plunger to move by a set distance each time through the blade; the driving mechanism is matched with an operation part elastically connected to the shell so as to drive the driving mechanism to act; the operation part is matched with the medicine feeding mechanism arranged in the suction nozzle and the medicine feeding pipe space, the operation part can drive the medicine feeding mechanism to act so as to achieve switching between the connection state and the disconnection state of the medicine feeding pipe space and the suction nozzle, and the medicine feeding device overcomes the defects of an existing powder aerosol medicine feeding device.

A flow channel applicable to a dual-reservoir powder inhaler device belongs to the field of drug delivery devices. It includes two medicine storage barrels, two independent medicine pits, two delivery channels, and a vortex dispersion chamber; each medicine storage barrel corresponds to one medicine pit; each medicine pit corresponds to one delivery channel; the two delivery channels and one vortex dispersion chamber form the flow channel of the dual-reservoir powder inhaler device; the said flow channel has two independent drug particle delivery channels, which can simultaneously deliver drugs from two independent medicine pits to the same vortex dispersion chamber; two different formulation prescriptions are separately filled in the two medicine storage barrels, making them correspond to different medicine pits and drug delivery channels, so that the powder inhaler particles of the two different prescriptions can be delivered from their respective independent medicine pits along their respective delivery channels to the common vortex dispersion chamber, and after being dispersed by the vortex dispersion chamber, they are delivered out of the powder inhaler device together, realizing the simultaneous administration of at least two different varieties of formulation prescriptions. It can be applicable to the design and manufacturing field of powder inhaler devices.

1. The name of the design product: medicinal powder aerosol inhaler (rotary type). 2. The use of the design product: for the delivery of medical drugs, such as asthma or chronic obstructive pulmonary disease, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: Design 1 perspective view 1. 5. Design 1 is designated as the basic design. 6. Other circumstances that need to be explained: The A part of the design product is made of translucent material.

The utility model provides a capsule breaking mechanism of a dry powder inhalation administration device, and belongs to the technical field of medical instruments. The capsule breaking mechanism of the dry powder inhalation administration device comprises a shell, a clamping mechanism is arranged on one side of the shell, a puncturing mechanism is arranged on one side of the clamping mechanism, a dust isolation cover is movably installed on the top of the shell, a top cover is fixedly installed on the top of the shell, and a suction nozzle is fixedly installed on the top of the top cover. Compared with the prior art, the capsule puncture needle has the advantages that the worm is arranged, the knob is manually rotated to drive the third limiting rod and the puncture needle body to move towards the capsule between the positioning clamps at the same time, and then the capsule can be punctured; the third limiting rod and the puncture needle body only need to enter the capsule for a small distance to puncture the capsule, and the situation that the whole puncture needle completely enters the capsule, and consequently medicine powder in the capsule is brought out by the puncture needle is avoided.

The invention provides naringin dry powder inhalation as well as a preparation method and application thereof, belongs to the technical field of pharmaceutical preparations, and particularly provides the naringin dry powder inhalation which comprises the following components in parts by mass: 1-30 parts of micronized naringin and 40-100 parts of a diluent, and the particle size distribution D90 of the micronized naringin is 1-30 [mu] m. The naringin dry powder inhalation provided by the invention is an inhalation administration preparation, has the advantages of high drug absorption rate and quick response, and the naringin dry powder inhalation provided by the invention has extremely low bitter taste and good patient compliance, and can be used for preparing an anti-inflammatory drug inhalant and / or a lung disease treatment drug.

The utility model belongs to the technical field of medical instruments, and particularly relates to a puncture needle for a dry powder inhalation capsule, which comprises an inhaler body, a suction nozzle in threaded connection with the top end of the inhaler body, and a medicine placing groove arranged in the inhaler body right below the suction nozzle, so that when the dry powder inhalation capsule is used, the suction nozzle can be opened to place the dry powder inhalation capsule in the medicine placing groove; then the suction nozzle is closed, then the two pressing blocks are pressed close to each other, the puncture needle penetrates through aseptic cotton in the lantern ring to be disinfected and then pierces into the capsule in the medicine containing groove from the puncture opening, so that the capsule is punctured, stress points can be increased for the puncture needle through supporting of the lantern ring, and the situation that the capsule cannot be punctured accurately due to shaking in the moving process is avoided; after puncturing, the pressing block is loosened, so that the puncture needle is automatically retracted into the aseptic cotton for disinfection through the first compression spring, and the effects that the puncture needle has enough force to penetrate through the dry powder inhalation capsule and automatic disinfection can be achieved after puncturing each time are effectively achieved.

The invention discloses a vacuum cold spraying nano-ceramic powder aerosol powder feeder, and relates to the field of vacuum cold spraying technology. The powder feeder is used for vacuum cold spraying of nano-ceramic powder, and the powder feeder includes a powder barrel, a power source and a rotating shaft. A screen is provided at the bottom of the powder barrel, and the screen is used to separate the bottom space of the powder barrel into an air intake chamber and a powder storage space; the power source is installed on the powder barrel; the rotating shaft is connected to the power source, and the bottom of the rotating shaft located in the powder barrel is connected to an impeller, and the middle of the rotating shaft located in the powder barrel is connected to a crushing brush, and the impeller and the crushing brush rotate with the rotation of the rotating shaft. Driven by the power source, the rotating shaft rotates, and the impeller can form a suction force. The nano-ceramic powder rises to the crushing brush under the dual effects of the rising power and the rotating wind force of the impeller. The agglomerated nano-ceramic powder is crushed by the impact of the rapid rotation of the crushing brush to form a powder aerosol state, and finally stable powder feeding is achieved through the top of the powder barrel.

The invention discloses inhalation type quercetin dry powder inhalation and a preparation method thereof, and belongs to the technical field of inhalation administration. Aiming at the problems of low oral bioavailability, poor targeting property and the like of quercetin, the dry powder inhalation is prepared from the following components in percentage by weight: 10 to 100 percent of quercetin, 0 to 85 percent of diluent and 0 to 5 percent of taste indicator, and the particle size of quercetin particles is D90lt; 20 [mu] m. The preparation method comprises the following steps: crushing the quercetin and the diluent, mixing with the taste indicator, sieving, spheroidizing in a spheroidizing disc to prepare spherical particles, and finally filling into an inhaler. The dry powder aerosol realizes lung targeted delivery through inhalation administration, has good fluidity and lung deposition effect, is mainly used for treating lung nodules, and provides an efficient and safe treatment scheme for lung diseases.

The present invention discloses active and passive flame-retardant, intumescent and water-repellent coating systems for fire protection, the passive system modality comprising a novel composition of a flame-retardant, intumescent and water-repellent coating with preventive passive fire protection properties and technology that are not offered by similar products available today. Said composition is water-based and is manufactured and designed to provide fire protection to the steel metal bearing structures in mixed-use buildings, walls, floors, and between floors by means of thin rigid layers of the composition which provide excellent strength and thermal protection, generating a thermal insulating barrier against the ignition source and, once combustion has started, providing robust protection when exposed to high temperatures and extreme turbulent forces of any type of fire generated either due to cellulosic fire or hydrocarbon fire. In the active system modality, the composition is in powder, aerosol or silicone form.

The invention relates to the production of hydrophobic or superhydrophobic sliding and protective coatings for the running surface of a winter sports device that comes into contact with ice or snow. The coating of the running surface is characterized in that the coating material consists of a ceramic or of a ceramic and one or more other materials, wherein the coating is applied using the powder aerosol deposition method.

The invention belongs to the technical field of powder aerosol deposition, and provides an aerosol dispersing device based on microwave induction heating and coating deposition equipment, and the aerosol dispersing device comprises a tank body and a microwave generating device. The tank body is provided with a heating cavity, the tank body is provided with a feed port and a discharge port which are communicated with the heating cavity, the tank body is further provided with a microwave feed-in port, the output end of the microwave generating device is located in the microwave feed-in port, the microwave generating device emits microwaves into the heating cavity through the microwave feed-in port, and the feed port and the discharge port are symmetrically arranged. The microwave generating device emits microwaves into the heating cavity, local heating is conducted through the microwaves, dynamic depolymerization of particles in aerosol is achieved, and secondary agglomeration of the particles is avoided, so that the particles in the aerosol are dispersed more evenly, and the tamping effect when the particles impact a substrate is improved; therefore, the porosity of the formed coating is reduced, and the bonding strength of the particles and the substrate is improved.

The invention discloses a heat-seal welding quality testing device and method for a dry powder inhalation powder aerosol aluminum foil bubble cap strip. The heat-seal welding quality testing device comprises an upper clamping unit and a lower clamping head. The lower chuck is fixedly arranged, is provided with a knob, and is used for clamping the front end of an aluminum foil bubble cap strip cover foil when the stripping force is tested or clamping the tail end of a bubble cap aluminum foil strip when the strength of an aluminum foil ring is tested; the upper clamping unit comprises a connector, an upper clamping head detachably mounted on the connector and an aluminum foil ring hook, the upper clamping head is used for clamping the front end of a base foil of the aluminum foil bubble cap strip when the stripping force is tested, and the aluminum foil ring hook is used for hooking an aluminum foil ring at the front end of a cover foil of the aluminum foil bubble cap strip when the strength of the aluminum foil ring is tested; a force value sensor is connected above the upper clamping unit; the lower portion of the force value sensor is fixedly connected with the connector of the upper clamping unit into a whole. The test equipment and the test method provided by the invention can be used for measuring the stripping force between the cover foil and the base foil of the aluminum foil bubble cap strip and the breaking strength of the aluminum foil ring so as to evaluate whether the heat sealing of the aluminum foil bubble cap strip and the heat sealing of the aluminum foil ring meet the quality standard or not.