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208 results about "Naringin" patented technology

Naringin is a flavanone-7-O-glycoside between the flavanone naringenin and the disaccharide neohesperidose. The flavonoid naringin occurs naturally in citrus fruits, especially in grapefruit, where naringin is responsible for the fruit's bitter taste. In commercial grapefruit juice production, the enzyme naringinase can be used to remove the bitterness created by naringin. In humans naringin is metabolized to the aglycone naringenin (not bitter) by naringinase present in the gut.

Preparation method and application of high-activity hierarchical pore boric acid imprinted hydrogel microsphere adsorbent

The invention discloses a preparation method of a high-activity hierarchical pore boric acid imprinted hydrogel microsphere adsorbent and application of the adsorbent to selective adsorption of a flavonoid compound naringin NRG. According to the invention, dopamine is used for modifying COFs so as to enhance surface functionalization of COFs; preparing a sulfydryl functionalized covalent organic framework microsphere; synthesizing sulfydryl microspheres by utilizing an emulsion interfacial polymerization method; preparing a COFs boron affinity imprinting microsphere adsorbent based on boron affinity interaction; the adsorbent is applied to selective adsorption of NRG in agricultural wastewater. The prepared adsorbent has a remarkable multilayer adsorption effect, and the adsorption capacity is remarkably improved through the boron affinity effect. The multi-stage pore structure of the COFs microspheres provides abundant sites for adsorption, and the mass transfer rate is remarkably improved. In addition, the prepared adsorbent shows remarkable specificity in the aspects of adsorption and separation of NRG, and a promising adsorption material is provided for industrial separation of NRG.
Owner:JIANGSU UNIV +1

Nano-composite hydrogel based on Mg-MOFs as well as preparation method and application of nano-composite hydrogel

The invention provides nano-composite hydrogel based on Mg-MOFs (magnesium-metal organic frameworks), which is characterized in that hollow mesoporous silica nanoparticles (HMSNs) are used as a core of the nano-composite hydrogel, magnesium-gallic acid metal organic frameworks (Mg-MOFs) are used as a shell of the nano-composite hydrogel, and a core-shell nano-composite material HMMs is formed; carrying out amination treatment on the core-shell nano composite material HMMs, and loading naringin (Nar) to obtain a drug-loaded core-shell nano composite material (N-HMMs (at) Nar); and carrying out a cross-linking reaction on the drug-loaded core-shell nano composite material (N-HMMs (at) Nar), methacrylic acid gelatin and PEGDA (Polyethylene Glycol Diacrylate), so as to form the nano composite hydrogel. The N-HMMs (at) Nar (at) GP hydrogel prepared by the invention has great application potential in bone defect repair.
Owner:JUDIAN YUNZHI MEDICAL TECHNOLOGY (HANGZHOU) CO LTD

Application of narirutin in improving intestinal flora homeostasis of food allergy organism

The invention belongs to the technical field of food functional ingredient nutriology research, and discloses application of narirutin in improving the intestinal flora homeostasis of food allergy organisms. The narirutin can adjust the relative abundance value of certain intestinal flora by adjusting the diversity of the intestinal flora of a food allergy body, improve the relative abundance of beneficial bacteria and harmful bacteria, and can influence the metabolism of short-chain fatty acid of the intestinal flora of the food allergy body, so that the food allergy body is improved. Further, the application of the narirutin in improving the intestinal flora homeostasis of food allergy organisms is realized. The application of narirutin in the research fields of nutriology, biology and pharmacology is expanded.
Owner:JILIN UNIVERSITY

Application of dihydroflavonoid compound naringin in promoting proliferation and differentiation of porcine muscle stem cells

The invention provides an application of dihydroflavonoid compound naringin in promoting proliferation and differentiation of porcine muscle stem cells to form myotubes, which is characterized in that the naringin is added into a DMEM / F12 culture medium containing 15% of fetal calf serum and 1% of double antibodies and a DMEM differential culture medium containing 2% of horse serum and 1% of double antibodies until the final concentration is 70 mu M, and the porcine muscle stem cells are respectively treated in proliferation and differentiation stages, hoechst 33342 staining and immunofluorescence staining methods are used for respectively judging the number of cells in the proliferation stage and the fluorescence area, fluorescence intensity and nuclear fusion rate of Myosin in myotubes formed in the differentiation stage. The relative proliferation multiple of the muscle stem cells treated by adding naringin and the fluorescence area, the fluorescence intensity and the nuclear fusion rate of Myosin in myotubes are obviously higher than those of a blank control group. By adopting the method, proliferation and differentiation of the porcine muscle stem cells can be promoted, and a new thought is provided for maintaining cell dryness and large-scale production of cultured meat.
Owner:NANJING AGRICULTURAL UNIVERSITY

Medicinal component detection method of traditional Chinese medicine composition UPLC-MS / MS

The invention provides a method for detecting medicinal components of a traditional Chinese medicine composition UPLC-MS / MS. The detection method can be used for identifying 14 medicinal components of the traditional Chinese medicine composition, namely saikoside A, saikoside D, naringin, paeoniflorin, hesperidin, chicoric acid, chlorogenic acid, salvianolic acid B, narcissoside, kaempferitrin, lobetyolin, amygdalin, hyperoside and rutin. And a reference is provided for evaluating the internal quality of the traditional Chinese medicine composition.
Owner:BAODING BUCHANG TIANHAO PHARMA

Culture system, culture method and application of gastrointestinal tumor organoid

The invention relates to the technical field of organoid culture, and relates to a culture system and a culture method for gastrointestinal tumor organoids for the first time, the culture system is formed by adding antioxidant active traditional Chinese medicine extracts such as naringin or polydatin on the basis of an existing culture system, when the culture system is used for culturing the gastrointestinal tumor organoid, the primary survival rate of the gastrointestinal tumor organoid and the proliferation rate after passage can be improved. Besides, the invention further provides application of the culture system of the gastrointestinal tumor organoid, the culture system and the cultured gastrointestinal tumor organoid are used for screening small-molecule targeted anti-tumor drugs, and a better in-vitro research model is provided for subsequent anti-tumor treatment.
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A

A preparation method and application of Huajuhong and Huajuhongtai for relieving cough, reducing phlegm, protecting lungs, enhancing efficacy and removing bitterness

The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a preparation method and application of Huajuhong and Huajuhong embryo for relieving cough, reducing phlegm, protecting lungs, enhancing efficacy and removing bitterness. The preparation method of the present invention is: take the raw materials (Huajuhong, Huajuhong embryo) and mix them with sodium bicarbonate aqueous solution or sodium carbonate aqueous solution, warm them at 50-90°C, and then dry them to obtain the prepared products. Experimental results show that the preparation method of Huajuhong and Huajuhong embryo of the present invention significantly changes the content of their ingredients, and the efficacy of the prepared prepared products is significantly improved, including a significant increase in the efficacy and activity of relieving cough, reducing phlegm and protecting lungs; moreover, the content of the main bitter substance naringin is significantly reduced after preparation, and the bitterness in the raw materials can be effectively removed, which is very beneficial for oral drinking by patients with cough, phlegm and lung damage.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE

HDPE (high-density polyethylene) resin composition for degradable packaging bottle and preparation method of HDPE resin composition

ActiveCN119371734ANaringinPolymer science
The invention belongs to the technical field of degradable materials, and particularly relates to an HDPE (high-density polyethylene) resin composition for a degradable packaging bottle and a preparation method of the HDPE resin composition. The degradable HDPE resin composition for the packaging bottle, provided by the invention, is prepared from 40 to 50 parts of modified HDPE, 20 to 30 parts of modified starch, 10 to 15 parts of a degradation aid, 5 to 8 parts of an antioxidant, 8 to 12 parts of nano silicon dioxide and 5 to 8 parts of oleamide. According to the invention, naringin and N-(2-aminoethyl)-3-aminopropyl methyl diethoxy silane are adopted to carry out composite modification on corn starch, so that the tensile strength and elongation at break of a starch film are effectively improved, and the modified starch is blended with glycerol, so that the technical problem of poor water resistance of starch-based biodegradable resin is effectively solved; high-temperature calcined oyster shell powder and a silane coupling agent are adopted to modify high-density polyethylene, so that the mechanical property of the high-density polyethylene material is effectively improved, meanwhile, microbial channels are provided for degradation of the high-density polyethylene material, and the degradation rate is increased.
Owner:YUYAO WEIHANG PLASTICS IND CO LTD

Traditional Chinese medicine skin cream for repairing skin and preparation method thereof

The invention relates to the technical field of skin care product preparation, in particular to traditional Chinese medicine skin care cream for repairing skin and a preparation method thereof. The preparation method comprises the following steps: preparing acylated alkyl glucoside; preparing a turpinia arguta extract; preparing a suspension of the naringin and the turpinia arguta extract; and preparing the traditional Chinese medicine skin cream for repairing the skin. According to the method, myristic acid and alkyl glycoside are used for preparing acylated alkyl glycoside, myristic acid and alkyl glycoside are subjected to acylation reaction through lipase Lipozyme435 enzyme, damage to a flavone structure in the microwave extraction process is avoided, after alkyl glycoside acylation, the lipophilicity is remarkably enhanced, and the lipophilicity of alkyl glycoside is remarkably reduced. Due to the enhanced lipophilicity, the alkyl glycoside can more effectively interact with fat-soluble flavonoid compounds, so that the solubility and dispersity of the alkyl glycoside in a fat phase are improved, the oxidation loss of flavonoid substances in the extraction process of the turpinia arguta leaves is reduced, and the content of the flavonoid substances in the turpinia arguta leaf extract is increased.
Owner:JIANGXI ACAD OF FORESTRY

Preparation method of high-content narirutin and hesperidin extract

The invention provides a preparation method of a high-content narirutin and hesperidin extract, which is characterized in that a microwave-assisted eutectic solvent optimization process is utilized to prepare narirutin and hesperidin in pericarpium citri reticulatae, and the extraction conditions of a microwave-assisted eutectic solvent are optimized through a single factor experiment and a BBD response surface experiment. The optimal extraction conditions are as follows: the molar ratio of choline chloride to ethylene glycol is 1: 6, the water content is 10%, the solid-liquid ratio is 10mg / mL, the microwave extraction temperature is 94 DEG C, the time is 41 minutes, and the power is 400W. According to the method, the eutectic solvent is adopted as the extraction solvent, and the microwave-assisted extraction technology which has relatively high energy transmission efficiency and is easy to apply on a large scale is combined, so that the efficiency is expected to be improved in industrial application in the future, the extraction process is more environment-friendly and sustainable, and a new thought is provided for deep processing and utilization of rutaceous plant resources.
Owner:JILIN UNIVERSITY

Making method of unsterilized pickled Chinese cabbages, pickled Chinese cabbage bag and seasoning bag

The invention relates to the technical field of food processing, and particularly discloses a preparation method of unsterilized pickled Chinese cabbages, a pickled Chinese cabbage bag and a seasoning bag. Comprising the following steps: S1, salting in a pond; s2, secondary jar soaking: washing the salted vegetable embryos, transferring the washed vegetable embryos into a jar, and adding saline water for fermentation; wherein Baijiu and brown sugar are added into the saline water; s3, pretreatment of pickled Chinese cabbages; s4, material water preparation: preparing a water solution with the content of a natural preservative being 0.3-0.8% o; the natural preservative comprises olive leaf extract, lemon juice, black pepper, aloe, liquorice and naringin; and S5, packaging the pickled Chinese cabbages: mixing the pickled Chinese cabbages and the aqueous solution, and bagging to prepare pickled Chinese cabbage bags. The natural preservative is used for inhibiting bacteria, pasteurization is not carried out, and the taste and color of the pickled Chinese cabbages are ensured while the bacterial colony content of the pickled Chinese cabbages is within an allowable range; by controlling the fermentation process, the content of acetic acid in the pickled Chinese cabbages can be greatly increased, so that the taste of the pickled Chinese cabbages is improved.
Owner:SICHUAN TIANWEI FOOD CO LTD

Composition and application thereof

The invention discloses a composition and application thereof, and the composition comprises synephrine or a pharmaceutically acceptable salt thereof, and further comprises naringin, neohesperidin and / or hesperidin. The composition prepared by compounding the synephrine or the pharmaceutically acceptable salt thereof with the naringin, the neohesperidin and / or the hesperidin has the effects of relieving, repairing, resisting wrinkles, easing pain, relieving itching or resisting allergy when being used as a functional component of a skin care product; when being used as a functional component of a scalp care product, the shampoo has the effects of removing dandruff, removing oil, relieving itching or preventing alopecia.
Owner:SHANGHAI JAKA BIOTECH CO LTD

Preparation method and application of high-activity multi-level pore boric acid imprinting hydrogel microsphere adsorbent

The application discloses a preparation method of a high-activity multi-level-pore boronic acid imprinting hydrogel microsphere adsorbent and application of the adsorbent to selective adsorption of a flavonoid compound naringin (NRG). The application enhances surface functionalization of COFs by dopamine modification, prepares thiol functionalized covalent organic framework microspheres, synthesizes thiol microspheres by using an emulsion interfacial polymerization method, prepares COFs boron affinity imprinting microsphere adsorbents based on boron affinity, and applies the adsorbents to selective adsorption of NRG in agricultural wastewater. The prepared adsorbent has a significant multi-layer adsorption effect, and the adsorption capacity is significantly improved by using boron affinity. The multi-level-pore structure of the COFs microspheres provides abundant sites for adsorption, and significantly improves the mass transfer rate. In addition, the prepared adsorbent has significant specificity in adsorption and separation of NRG, and provides a promising adsorption material for industrialized separation of NRG.
Owner:JIANGSU UNIV +1

A detection method for orange and bitter orange formula granules

The present invention relates to the technical field of detection of Chinese medicine formula granules, and discloses a detection method for orange and citrus aurantium formula granules. The method comprises first comparing the correspondence of characteristic peaks in the chromatograms of the test solution and the control medicinal material solution, and then further detecting the citrus aurantium formula granules according to the peak area ratio α1 of rutin naringin to naringin and the peak area ratio α2 of neohesperidin to hesperidin. The UPLC detection method has good accuracy, repeatability and separation, shortens the detection time, and is easy to operate. The present invention uses the simulated formula granule extraction solution as the evaluation benchmark, can accurately detect whether the formula granules are orange and citrus aurantium formula granules, makes up for the vacancy in the technical field of its origin identification, and the method can be used as an exclusive identification method for orange and citrus aurantium formula granules.
Owner:SHANDONG INST FOR FOOD & DRUG CONTROL

Application of CsCOMT2 gene in breeding of new citrus varieties

ActiveCN120905289BBiotechnologyNaringin
The application discloses application of a CsCOMT2 gene in breeding of new citrus varieties, belongs to the technical field of genetic engineering, and particularly relates to application of the CsCOMT2 gene in breeding of new citrus varieties, wherein the CDS sequence of the CsCOMT2 gene is shown as SEQ ID NO. 1. The application promotes the content of vitamin P-2, naringin, hesperidin and / or jaceosid in citrus peels by overexpressing the CsCOMT2 gene, and indicates that the CsCOMT2 gene can be used as a candidate gene for breeding of new citrus varieties with high content of vitamin P-2, naringin, hesperidin and / or jaceosid, and a functional new citrus variety is bred by using a genetic engineering method.
Owner:GERMPLASM INNOVATION GRAND SCIENCE CENTER OF WESTERN CHINA (CHONGQING) SCIENCE CITY +1

A method for simultaneously determining multiple index components in Wendan Tablets

The present invention provides a method for simultaneously determining multiple index components in Wendan Tablets. In this method, Wendan Tablets are used as test samples for high-performance liquid chromatography detection to simultaneously determine p-hydroxycinnamic acid, naringin, hesperidin, and glycyrrhizic acid in Wendan Tablets. The method of the present invention can also quantitatively determine the contents of the above four components in Wendan Tablets, and the quantitative determination methods include the external standard method and the multiple components by single marker method. The determination method of the present invention realizes the qualitative and quantitative determination of multiple components (p-hydroxycinnamic acid, naringin, hesperidin, and glycyrrhizic acid) in Wendan Tablets. Among them, the multiple components by single marker quantitative detection method not only ensures the quality, stability, and controllability of the preparation, but also reduces the detection cost of purchasing reference substances, achieving excellent technical effects and having broad application prospects.
Owner:ZHANGZHOU PIEN TZE HUANG PHARM

Bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and preparation method of bionic bone scaffold composite material

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.
Owner:SHANGHAI YUANDA NEW MATERIAL TECH CO LTD

A method for evaluating the debittering effect of citrus juice resin adsorption

The present invention belongs to the field of food testing technology and provides a method for evaluating the debittering effect of citrus juice by resin adsorption. The method comprises the following steps: adding a sucrose ester emulsifier solution to a naringin solution, measuring the initial and final interfacial tension values, and obtaining the interfacial tension difference; adding the sucrose ester emulsifier solution during the citrus juice preparation process, and then debittering the citrus juice by resin adsorption to obtain the debittered citrus juice; and using the interfacial tension difference of the naringin solution containing the sucrose ester emulsifier as an indicator to determine the debittering effect of the citrus juice by resin adsorption. The present invention evaluates the debittering effect of citrus juice by resin adsorption by measuring the interfacial tension difference of the naringin solution containing the sucrose ester emulsifier. This evaluation method has the advantages of strong anti-interference ability, avoids interference from components such as pectin and pigments, excellent data reproducibility, and low reagent consumption.
Owner:JIANGXI AGRICULTURAL UNIVERSITY +1

Processing technology of rhizoma drynariae

The invention discloses a processing technology of rhizoma drynariae, and belongs to the technical field of processing. The processing technology comprises the following steps: step 1, removing leaves and silt from fresh rhizoma drynariae, washing, slicing, and drying in the sun; step 2, processing the highland barley wine: taking the dried slices, adding the highland barley wine, uniformly stirring, thoroughly covering, frying with slow fire, and cooling to obtain the highland barley wine prepared decoction pieces; and step 3, adding the highland barley rice water into the wine-prepared highland barley decoction pieces, uniformly stirring, thoroughly covering, frying with the highland barley rice hull bran, and frying until the highland barley rice hull bran is dry to obtain the wine-prepared highland barley decoction pieces. According to the preparation method, the traditional processing method of sand blanching and salting is abandoned, the highland barley wine is firstly adopted for processing, then the highland barley rice water is adopted for moistening and the highland barley rice husk bran is adopted for frying, the effect of highland barley in broken bone supplementing processing is fully utilized, the spleen tonifying effect can be further enhanced by means of the highland barley rice, and the spleen tonifying and stomach invigorating effects of the decoction piece are improved. Meanwhile, the content of naringin in the decoction pieces can be remarkably increased through the processes of processing with highland barley wine, moistening with water and frying with bran of highland barley husks.
Owner:SHIJIAZHUANG ZANGNUO BIOTECH

Immature bitter orange extracellular vesicle-like particle as well as preparation method and application thereof

The invention belongs to the technical field of traditional Chinese medicines, and discloses an immature bitter orange-derived extracellular vesicle-like nanoparticle, which is characterized in that the immature bitter orange-derived extracellular vesicle-like nanoparticle is prepared by the steps of crushing immature bitter orange, filtering, centrifuging and resuspending, the average particle size is 60-120 nm, and the particle size of the immature bitter orange-derived extracellular vesicle-like nanoparticle is 20-30 nm. The extracellular vesicle-like nanoparticles are used for entrapment of at least one of naringin, neohesperidin, naringenin and hesperidin. The extracellular vesicle-like nanoparticles derived from immature bitter oranges are simple in preparation method, have liver targeting and good stability, and can be used for preparing medicines for preventing and / or treating liver injury, depression and breast cancer.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Composition for inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin

The invention discloses a composition for inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin. The composition comprises the following components in parts by weight: 1-5 parts of a sophora flavescens extract; 2-15 parts of a radix scutellariae extract; 5-10 parts of a white peony root extract; 0.2 to 5 parts of a grapefruit extract; and 1-5 parts of pomegranate extract. The composition prepared from the radix sophorae flavescentis extract, the radix scutellariae extract, the radix paeoniae alba extract, the grapefruit extract and the pomegranate extract takes sophocarpidine, baicalin, paeoniflorin, naringin and punicalagin as main functional components to play a synergistic effect, so that the composition has very remarkable effects of inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin.
Owner:RENHE GLOBAL (SHANGHAI) GRAND HEALTH RESEARCH INSTITUTE CO LTD

Quality control method for stir-fried rhizoma atractylodis macrocephalae with fructus aurantii

PendingCN120369876AComponent separationNaringinAtractylenolide II
The invention belongs to the technical field of quality detection of traditional Chinese medicines, and discloses a quality detection method of rhizoma atractylodis macrocephalae fried with fructus aurantii, which is characterized by comprising the following steps: performing qualitative analysis on rhizoma atractylodis macrocephalae fried with fructus aurantii by respectively adopting a thin-layer chromatography and an HPLC (High Performance Liquid Chromatography) characteristic chromatogram; a high performance liquid phase external standard curve method is adopted to carry out quantitative analysis on atractylenolide I, atractylenolide II, atractylenolide III, naringin and neohesperidin in the fructus aurantii fried bighead atractylodes rhizome. The invention establishes a thin-layer identification method for rhizoma atractylodis macrocephalae and fructus aurantii in a fructus aurantii fried rhizoma atractylodis macrocephalae processed product; according to the method for establishing the fingerprint spectrum, the similarity of 10 batches of rhizoma atractylodis macrocephalae fried with fructus aurantii ranges from 0.991 to 1.000; the method for determining the content of atractylenolide I, atractylenolide II, atractylenolide III, naringin and neohesperidin is established, scientific support is provided for formulating the quality standard of the characteristic processing decoction pieces of the temporary prescription, and effective guarantee is provided for clinical application of the decoction pieces.
Owner:CHANGZHOU FOOD DRUG & FIBER QUALITY SUPERVISION & INSPECTION CENT (CHANGZHOU GRAIN & OIL QUALITY SUPERVISION & INSPECTION STATION CHANGZHOU FIBER INSPECTION INST)

Sweetener composition and taste-improving agent

PendingUS20260182611A1NaringinNaringenin
The present invention provides a sweetener composition with improved taste quality of a sweet substance. The present invention relates to a sweetener composition containing the following components (A), (B), and (C): (A) at least one γ-glutamyl peptide selected from the group consisting of a compound represented by the formula (I): γ-Glu-X-Gly (I) wherein X is an amino acid residue or an amino acid derivative residue, and a compound represented by the formula (II): γ-Glu-Y (II) wherein Y is an amino acid residue or an amino acid derivative residue, or a salt thereof, (B) at least one compound selected from the group consisting of naringenin, hesperetin, and pinocembrin, or a salt thereof, and (C) a sweet substance.
Owner:AJINOMOTO CO INC

Citrus double-factor anti-allergy plant extract as well as preparation method and application thereof

The invention discloses a citrus two-factor anti-allergy plant extract and a preparation method and application thereof. The citrus two-factor anti-allergy plant extract comprises poncirin and naringin in a mass ratio of (20-25): (6-10). The preparation method of the citrus double-factor anti-allergy plant extract comprises the following steps: carrying out heating reflux on crushed citrus fruits in a 50-80% ethanol solution for 5-8 hours to obtain an extracted crude product; slowly adding an extracted crude product to the column, and controlling the flow rate to be 1-2BV / h; and then eluting with 3-5BV distilled water to remove water-soluble impurities. And eluting with a 30-40% ethanol solution of 2-3BV, collecting the eluent, concentrating, and recrystallizing to obtain the naringin. And eluting with a 50-70% ethanol solution of 2-3BV, collecting the eluent, concentrating, and recrystallizing to obtain poncirin. When the plant extract is used in cosmetics, the cosmetics can have good moisturizing, soothing and other effects.
Owner:JIANGSU BIOEDEN BIOTECHNOLIGY CO LTD

Preparation method and quality detection method of classic famous prescription immature bitter orange and Chinese herbaceous peony powder

The invention provides a preparation method of fructus aurantii immaturus and paeonia lactiflora powder of a classic famous formula The invention also provides a method for detecting the quality of the fructus aurantii immaturus and paeonia lactiflora powder prepared by the preparation method of the classic famous prescription fructus aurantii immaturus and paeonia lactiflora powder. The invention establishes a preparation process of the immature bitter orange and Chinese herbaceous peony powder preparation, and particularly, a process route and key process parameters obtained through systematic research on immature bitter orange charcoal frying process parameters in the formula not only accord with description of the medicine in ancient books, but also can meet actual equipment conditions of modern large-scale production. Within the determined key process parameter range, the decrease amplitude of three heat-sensitive components, namely catechin, narirutin and naringin, which are easy to decompose after being heated in the immature bitter orange charcoal can be controlled within 10%, so that the effectiveness and the quality controllability of the product are ensured. The UPLC method established by the invention can more quickly realize simultaneous detection of eight components in the immature bitter orange and Chinese herbaceous peony powder, can be used as an evaluation method for the process research, and can also be used for controlling the product quality in the production of the immature bitter orange and Chinese herbaceous peony powder.
Owner:SICHUAN NEO GREEN PHARMA TECH DEV

Construction method of fingerprint spectrum of Shenxiong Tongmai capsule

The invention relates to a construction method of a fingerprint spectrum of Shenxiong Tongmai capsule, which comprises the following steps: dissolving a ferulic acid standard substance, a hesperidin standard substance, a ginsenoside Re standard substance, a neohesperidin standard substance and a naringin standard substance in methanol to prepare a mixed reference substance solution; the method comprises the following steps: respectively dissolving contents of Shenxiong Tongmai capsules in a plurality of batches in a methanol aqueous solution to prepare a plurality of test solutions; respectively carrying out high performance liquid chromatography detection on the mixed reference substance solution and the plurality of test sample solutions to obtain a high performance liquid chromatogram of the mixed reference substance solution and high performance liquid chromatograms of the plurality of test sample solutions; determining characteristic peaks and identifying chemical components of the characteristic peaks, and calculating relative retention time of other characteristic peaks by taking the characteristic peak corresponding to hesperidin as a reference peak to obtain the fingerprint spectrum. The fingerprint spectrum obtained by the construction method disclosed by the invention can well reflect information of a plurality of index components of the Shenxiong Tongmai capsule.
Owner:NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE

A highly active epiglottis-removing decoction and its application in the preparation of antitussive drug compositions

PendingCN122075510Aachieve enrichmentSignificant antitussive activityOrganic active ingredientsGranular deliveryNaringinAntitussive drugs
This invention relates to a highly active effective fraction of the Epiglottis-Clearing Decoction and its application in the preparation of antitussive drug compositions, belonging to the field of traditional Chinese medicine extract technology. The effective fraction contains hydroxysaffron yellow A, paeoniflorin, naringin, and neohesperidin, with the total content of these four components not less than 20% of the total mass of the effective fraction. The effective fraction of this invention is prepared by purification with macroporous resin. Compared with the freeze-dried powder of the traditional Epiglottis-Clearing Decoction, the total content of the four active ingredients is increased from 3.32% to 20.87%, achieving a more than 6-fold high-efficiency enrichment. Animal pharmacodynamic experiments show that the antitussive effect of a low dose (275.5 mg / kg) of this effective fraction is comparable to that of the freeze-dried powder of the original decoction (1928 mg / kg), reducing the dosage to about 1 / 7 of the original formula, demonstrating a significant "synergistic effect with reduced dosage" technical effect. The effective active ingredients provided by this invention have a clear content and stable quality, and can be made into modern preparations such as tablets, capsules or granules, solving the problems of large volume, inaccurate dosage and poor patient compliance of traditional decoctions.
Owner:BINZHOU MEDICAL COLLEGE +1

Oral composition and method for ameliorating harsh taste

An object of this invention is to suppress the harsh taste particular to an extract of a plant of the genus Salacia. An oral composition comprises an extract of a plant of the genus Salacia and naringin, the naringin being present in an amount of 0.001 to 6 parts by weight per part by weight of the extract of a plant of the genus Salacia, on a dry weight basis. A method for ameliorating the harsh taste of an extract of a plant of the genus Salacia comprises combining 0.001 to 6 parts by weight of naringin with 1 part by weight of the extract of a plant of the genus Salacia, on a dry weight basis.
Owner:KOBAYASHI PHARMA CO LTD

Heart-protecting granule identification and quality control method based on thin layer chromatography

The invention discloses a heart-protecting granule identification and quality control method based on thin layer chromatography, and belongs to the technical field of medicine detection. The thin-layer chromatography identification method comprises the following steps: identifying astragalus membranaceus by taking astragaloside as a reference substance, identifying wine-treated rhubarb by taking chrysophanol and emodin as reference substances, identifying leech by taking a leech medicinal material as a reference substance, identifying liquorice by taking liquiritin and a liquorice medicinal material as reference substances, and identifying radix rehmanniae by taking catalpol as a reference substance. And identifying salvia miltiorrhiza by taking salvianolic acid B and salvia miltiorrhiza medicinal materials as reference substances, and identifying fructus aurantii by taking naringin and neohesperidin as reference substances. By establishing the thin-layer chromatography identification method of the heart-protecting granules, an exclusive developing solvent and a developing mode are adopted, accurate identification is achieved according to the characteristics of spot colors, fluorescence characteristics and the like of corresponding positions of a test substance chromatography, a reference substance and a reference medicinal material chromatography, and the method is easy and convenient to operate, low in detection cost and high in repeatability and specificity; and quality control can be effectively carried out in the production process of the heart-protecting granules.
Owner:ZHUHAI TIANDA RES & DEV CO LTD