88 results about "Naringin" patented technology

The application discloses application of a CsCOMT2 gene in breeding of new citrus varieties, belongs to the technical field of genetic engineering, and particularly relates to application of the CsCOMT2 gene in breeding of new citrus varieties, wherein the CDS sequence of the CsCOMT2 gene is shown as SEQ ID NO. 1. The application promotes the content of vitamin P-2, naringin, hesperidin and / or jaceosid in citrus peels by overexpressing the CsCOMT2 gene, and indicates that the CsCOMT2 gene can be used as a candidate gene for breeding of new citrus varieties with high content of vitamin P-2, naringin, hesperidin and / or jaceosid, and a functional new citrus variety is bred by using a genetic engineering method.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention belongs to the technical field of traditional Chinese medicines, and discloses an immature bitter orange-derived extracellular vesicle-like nanoparticle, which is characterized in that the immature bitter orange-derived extracellular vesicle-like nanoparticle is prepared by the steps of crushing immature bitter orange, filtering, centrifuging and resuspending, the average particle size is 60-120 nm, and the particle size of the immature bitter orange-derived extracellular vesicle-like nanoparticle is 20-30 nm. The extracellular vesicle-like nanoparticles are used for entrapment of at least one of naringin, neohesperidin, naringenin and hesperidin. The extracellular vesicle-like nanoparticles derived from immature bitter oranges are simple in preparation method, have liver targeting and good stability, and can be used for preparing medicines for preventing and / or treating liver injury, depression and breast cancer.

The invention discloses a composition for inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin. The composition comprises the following components in parts by weight: 1-5 parts of a sophora flavescens extract; 2-15 parts of a radix scutellariae extract; 5-10 parts of a white peony root extract; 0.2 to 5 parts of a grapefruit extract; and 1-5 parts of pomegranate extract. The composition prepared from the radix sophorae flavescentis extract, the radix scutellariae extract, the radix paeoniae alba extract, the grapefruit extract and the pomegranate extract takes sophocarpidine, baicalin, paeoniflorin, naringin and punicalagin as main functional components to play a synergistic effect, so that the composition has very remarkable effects of inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin.

A patch composition for targeting herpes virus comprising the following ingredients: a patch base, trisodium phosphate, malic acid, sorbitol, sodium benzoate, cellulose gum, peppermint, sodium saccharin, naringin, wind wheel grass extract, xanthan gum, polyethylene glycol-8, calcium carbonate, hydroxyethyl cellulose, hydroxypropyl guar gum, sodium nitrate, hydrated silica, sodium lauryl sulfate, strontium chloride hexahydrate, tranexamic acid, two-faced needle extract, sodium monofluorophosphate, sea salt, potassium nitrate, sodium chloride, and purified water q.s.

The present invention provides a sweetener composition with improved taste quality of a sweet substance. The present invention relates to a sweetener composition containing the following components (A), (B), and (C): (A) at least one γ-glutamyl peptide selected from the group consisting of a compound represented by the formula (I): γ-Glu-X-Gly (I) wherein X is an amino acid residue or an amino acid derivative residue, and a compound represented by the formula (II): γ-Glu-Y (II) wherein Y is an amino acid residue or an amino acid derivative residue, or a salt thereof, (B) at least one compound selected from the group consisting of naringenin, hesperetin, and pinocembrin, or a salt thereof, and (C) a sweet substance.

The invention discloses a citrus two-factor anti-allergy plant extract and a preparation method and application thereof. The citrus two-factor anti-allergy plant extract comprises poncirin and naringin in a mass ratio of (20-25): (6-10). The preparation method of the citrus double-factor anti-allergy plant extract comprises the following steps: carrying out heating reflux on crushed citrus fruits in a 50-80% ethanol solution for 5-8 hours to obtain an extracted crude product; slowly adding an extracted crude product to the column, and controlling the flow rate to be 1-2BV / h; and then eluting with 3-5BV distilled water to remove water-soluble impurities. And eluting with a 30-40% ethanol solution of 2-3BV, collecting the eluent, concentrating, and recrystallizing to obtain the naringin. And eluting with a 50-70% ethanol solution of 2-3BV, collecting the eluent, concentrating, and recrystallizing to obtain poncirin. When the plant extract is used in cosmetics, the cosmetics can have good moisturizing, soothing and other effects.

The invention provides a preparation method of fructus aurantii immaturus and paeonia lactiflora powder of a classic famous formula The invention also provides a method for detecting the quality of the fructus aurantii immaturus and paeonia lactiflora powder prepared by the preparation method of the classic famous prescription fructus aurantii immaturus and paeonia lactiflora powder. The invention establishes a preparation process of the immature bitter orange and Chinese herbaceous peony powder preparation, and particularly, a process route and key process parameters obtained through systematic research on immature bitter orange charcoal frying process parameters in the formula not only accord with description of the medicine in ancient books, but also can meet actual equipment conditions of modern large-scale production. Within the determined key process parameter range, the decrease amplitude of three heat-sensitive components, namely catechin, narirutin and naringin, which are easy to decompose after being heated in the immature bitter orange charcoal can be controlled within 10%, so that the effectiveness and the quality controllability of the product are ensured. The UPLC method established by the invention can more quickly realize simultaneous detection of eight components in the immature bitter orange and Chinese herbaceous peony powder, can be used as an evaluation method for the process research, and can also be used for controlling the product quality in the production of the immature bitter orange and Chinese herbaceous peony powder.

This invention relates to a highly active effective fraction of the Epiglottis-Clearing Decoction and its application in the preparation of antitussive drug compositions, belonging to the field of traditional Chinese medicine extract technology. The effective fraction contains hydroxysaffron yellow A, paeoniflorin, naringin, and neohesperidin, with the total content of these four components not less than 20% of the total mass of the effective fraction. The effective fraction of this invention is prepared by purification with macroporous resin. Compared with the freeze-dried powder of the traditional Epiglottis-Clearing Decoction, the total content of the four active ingredients is increased from 3.32% to 20.87%, achieving a more than 6-fold high-efficiency enrichment. Animal pharmacodynamic experiments show that the antitussive effect of a low dose (275.5 mg / kg) of this effective fraction is comparable to that of the freeze-dried powder of the original decoction (1928 mg / kg), reducing the dosage to about 1 / 7 of the original formula, demonstrating a significant "synergistic effect with reduced dosage" technical effect. The effective active ingredients provided by this invention have a clear content and stable quality, and can be made into modern preparations such as tablets, capsules or granules, solving the problems of large volume, inaccurate dosage and poor patient compliance of traditional decoctions.

The application provides a HPLC-based method for constructing a fingerprint spectrum of Tianyang Qianggu Yin and application thereof, and belongs to the technical field of traditional Chinese medicine detection.The method provided by the application comprises the steps of preparing a test sample solution, preparing a mixed control sample solution, HPLC determination, fingerprint spectrum construction and content determination.The application first establishes a HPLC fingerprint spectrum suitable for water-soluble extracts of Tianyang Qianggu Yin compound, and simultaneously realizes accurate content determination of six components, i.e., neotamanoxin, naringin, alpinumisine A, alpinumisine B, alpinumisine C and icariin.The application has strong specificity, high precision, good repeatability and excellent accuracy.The application provides scientific and controllable technical support for the production quality consistency and efficacy stability of Tianyang Qianggu Yin, and can be used for quality control and batch consistency evaluation of the compound preparation.

The invention relates to the technical field of medical preparations, in particular to oral nano-particles for promoting healing of diabetic wounds and a preparation method of the oral nano-particles. The oral nano-particles provided by the invention are prepared from zein, vitamin E polyethylene glycol succinate, naringin and octenyl succinic anhydride starch ester through an anti-solvent in combination with electrostatic adsorption. The oral nano-particles provided by the invention can effectively promote healing of diabetic wounds.

The invention belongs to the technical field of medical gel, and particularly relates to gynecological antibacterial gel and a preparation method thereof. The gel comprises an antibacterial phase and a bacterium promoting phase, and broad-spectrum inhibition of common pathogenic bacteria is achieved through the synergistic proportion of naringin, nisin and ethyl lauroyl arginate hydrochloride; meanwhile, a lactobacillus rhamnosus metabolite, sodium hyaluronate and the like are introduced to construct a bacterium promoting phase, and probiotic colonization and vagina micro-ecological balance reconstruction are promoted. The pH value of the gel is stabilized at 4.0-4.5, and the gel has good rheological properties and retention performance. In the preparation method, all the components are added step by step, the system temperature and stirring conditions are controlled, and the component activity and the product stability are guaranteed. The traditional Chinese medicine composition can effectively relieve bacterial vaginitis, fungal infection and micro-ecological disorder, and has a synergistic, safe and mild comprehensive nursing effect.

This invention discloses a method for enhancing the high-temperature resistance of citrus through exogenous spraying of naringin, belonging to the field of agricultural technology. The method involves preparing naringin into a formulation and spraying it exogenously onto the leaves of citrus plants. Experiments show that after treatment with naringin, phenotypic damage such as wilting and curling of citrus seedling leaves under high-temperature stress is significantly alleviated; the maximum photochemical efficiency of photosystem II (Fv / Fm) is significantly increased; electrolyte leakage rate and malondialdehyde content are significantly reduced; and the accumulation of hydrogen peroxide and superoxide anions is effectively inhibited. This invention utilizes naturally sourced naringin to significantly enhance the tolerance of citrus to high-temperature stress through multiple mechanisms, including maintaining photosynthetic system function, protecting cell membrane integrity, inhibiting membrane lipid peroxidation, and scavenging reactive oxygen species. Furthermore, the method is simple to operate, environmentally friendly, and low-cost, making it suitable for stress-resistant citrus cultivation.

The application discloses a content determination method of Xintong oral liquid, which adopts UPLC method to determine the contents of puerarin, daidzin, 2,3,5,4 ’ tetrahydroxystilbene-2-O-beta-D-glucoside, naringin and icariin in the preparation. The quality detection method is stable and reliable, has strong specificity and good reproducibility, can comprehensively and effectively control the quality of the Xintong oral liquid, is favorable for stabilizing the product quality, ensures the safety and effectiveness of clinical medication, and thus better meets the needs of medical treatment and market.

The purpose of the present invention is to provide a novel means for improving the mouthfeel of a protein-containing ingredient and to provide a food / beverage product composition containing a protein-containing ingredient that has an excellent mouthfeel. Using glucosyl naringin makes it possible to improve the mouthfeel of a protein-containing ingredient.

The invention discloses a naringin carbon quantum dot-based bone-targeting nanocomposite as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, preparing naringin-derived carbon quantum dots (N-CQDs); 2, preparing hybrid silicon dioxide / hydroxyapatite nano particles MH; (3) preparing amino functionalized MH nano particles MH-NH2; 4, adding the activated N-CQDs solution into the MH-NH2 solution, and carrying out stirring reaction at room temperature to prepare MH-CQDs; and 5, dispersing the NHS-PEG-Mal into the MH-CQDs solution, slowly stirring, and dialyzing after the reaction is completed, so as to obtain the P-coated MH-CQDs. According to the nano-composite disclosed by the invention, a natural drug naringin with osteogenic activity is creatively converted into N-CQDs with a pharmacological function and a fluorescent tracing capability, and the N-CQDs are combined with a bionic silicon dioxide-hydroxyapatite substrate, so that the essential fusion of a'drug-probe 'function is realized.

The invention discloses a multi-index content determination method of hovenia acerba and rhizoma atractylodis bowel-relaxing granules, and belongs to the technical field of traditional Chinese medicine detection. The invention establishes a high performance liquid chromatography method for simultaneously determining nine components including caffeic acid, chicoric acid, naringin, naringin, hesperidin, neohesperidin, chrysophanol, aurantio-obtusin and atractylenolide I in a preparation, and the content of the components is calculated through a relative correction factor by taking caffeic acid as an internal reference by adopting a quantitative analysis of multi-components by single marker. According to the method, effective detection of the immature bitter orange medicinal material and the immature bitter orange base source is realized, and the immature bitter orange and the sweet orange base source of the traditional Chinese medicine immature bitter orange can be accurately distinguished, so that more comprehensive and accurate quality control of the traditional Chinese medicine is realized, and the stability and consistency of clinical efficacy of the traditional Chinese medicine are guaranteed.

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof. Comprising the following raw materials in parts by weight: 25-35 parts of honey-fried astragalus membranaceus, 10-15 parts of roasted rhizoma atractylodis macrocephalae, 8-10 parts of ginseng, 5-8 parts of elecampane, 2-4 parts of fructus amomi, 12-18 parts of codonopsis pilosula, 12-18 parts of poria cocos, 8-10 parts of vinegar-processed curcuma zedoary, 2-4 parts of pseudo-ginseng, 8-12 parts of oldenlandia diffusa, 10-15 parts of medlar, 8-10 parts of pericarpium citri reticulatae, 5-7 parts of ginger processed pinellia, 0.08-0.12 part of naringin and 5-7 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention takes spleen invigorating and qi supplementing, qi regulating and blood activating, precise regulation and control and mucous membrane repairing as the core, specifically solves the pathogenesis of spleen deficiency and qi stagnation type CAG with deficiency in root and excess in excess, inhibits the progression of precancerous lesions, and improves the treatment effectiveness and safety.

The invention discloses an absorbable hernia patch with biological activity and a preparation method, the absorbable hernia patch comprises a patch, the thickness of the patch is 1mm, a coaxial electrostatic spinning technology is adopted to prepare fibers with a core-shell structure, the fibers are prepared by compounding poly (p-dioxanone) and poly (L-lactic acid), the core-shell structure comprises an outer layer material and an inner layer material, and the inner layer material is a porous material. Naringenin is loaded in the patch; controllable degradation and mechanical support are achieved, poly (p-dioxanone) and poly (L-lactic acid) are adopted as substrate materials, shell-core structure fibers are formed through coaxial electrostatic spinning, tissue repair is promoted through drug functionalization design, naringenin with biological activity is loaded in the patch, the effects of resisting inflammation and promoting angiogenesis and collagen deposition are achieved, and the anti-inflammatory effect is achieved. The patch is complete in fiber morphology, the tensile strength and the elongation at break both reach the level required by abdominal wall repair, the high quality residual rate is kept in the degradation process, and the naringenin can achieve slow release and continuously play a role.

The invention discloses a composition with effects of nourishing the lung, invigorating the spleen, tonifying the kidney and resisting fatigue, a preparation, a preparation method and application, and belongs to the technical field of compositions. The composition with the effects of nourishing the lung, invigorating the spleen, tonifying the kidney and resisting fatigue is prepared from exocarpium citri grandis, codonopsis pilosula, astragalus membranaceus, longan pulp, platycodon grandiflorum, asparagus cochinchinensis, rhizoma polygonati, rehmannia glutinosa, mulberries, liquorice, cistanche and naringin according to a proportion, and has the effects of nourishing the lung, invigorating the spleen, tonifying the kidney and resisting fatigue. Through scientific compatibility and reasonable preparation, the synergistic effect of all the components is fully exerted, the effects of regulating the internal environment of the organism, improving the immunity, resisting fatigue and improving the function and mental state of the human body on the whole are achieved, the effect of clearing the source is achieved, and good application prospects are achieved.

An object of the present invention is to provide a technique capable of reducing naringin-derived bitterness in a naringin-containing beverage and improving its good aftertaste.SOLUTION: The present invention provides a beverage comprising naringin and nerol and / or 6-methyl-5-hepten-2-one, wherein the content of nerol is 10 to 1000ppb, and the content of 6-methyl-5-hepten-2-one is 10 to 1000ppb.SELECTED DRAWING: None

The invention discloses a method for continuously extracting and separating naringin and pectin in shaddock peel. The method comprises the following steps: mixing shaddock peel powder with an alcohol amine-alcohol eutectic solvent, ultrasonically extracting naringin, and centrifugally separating to obtain a naringin extracting solution; deionized water is added into the extracting solution, CO gas is introduced, double aqueous phases are formed, and naringin is enriched in the lower phase; collecting a lower-phase solution to obtain a crude extract, heating and dissolving with ethanol, filtering, crystallizing and drying to obtain naringin; the method comprises the following steps: washing and drying residues after naringin extraction, extracting pectin by using a citric acid solution, filtering, precipitating with ethanol, centrifuging, purifying and drying to obtain the pectin. According to the method, the alcohol amine-alcohol eutectic solvent is applied to green extraction of the naringin for the first time, CO is utilized to trigger two aqueous phases to achieve efficient separation and purification of the naringin, meanwhile, multi-component high-value co-production of the naringin and pectin is achieved, the method has the advantages of being green, efficient, simple and convenient and the like, and a new way is provided for high-value utilization of shaddock peel waste.

The invention discloses an alpha-L-rhamnosidase mutant capable of efficiently converting naringin and application of the alpha-L-rhamnosidase mutant, and belongs to the technical field of gene engineering and enzyme engineering. The amino acid sequence of the alpha-L-rhamnosidase mutant is any one of SEQ ID NO.11 to SEQ ID NO.13. The invention further discloses a preparation method of the alpha-L-rhamnosidase. Compared with a wild type, the alpha-L-rhamnosidase mutant has the advantages that the specific enzyme activity is remarkably improved, the naringin hydrolysis efficiency is greatly improved, naringin can be efficiently and specifically catalyzed to be converted into Prunin with better solubility and biological activity, and the defect that an existing enzyme preparation is insufficient in catalytic performance in industrial application is overcome. The pH stability and thermal stability of the obtained mutant are improved while the optimum pH and temperature are maintained, high activity can be kept under the industrial catalysis condition, a catalyst with excellent performance is provided for green and efficient biological manufacturing of Prunin, and the mutant has important industrial application value.

The application discloses a kind of medicine food homologous sputum-removing and spleen-strengthening compositions and preparation method and application thereof, the composition includes: naringin 120-200 parts, hesperidin 80-100 parts, tuckahoe polysaccharide 150-250 parts, coix seed polysaccharide 80-120 parts, gingerol 10-20 parts, perillaldehyde 5-18 parts, glycyrrhizic acid 10-25 parts and glycyrrhizin flavone 8-24 parts by weight parts.The composition of the application can be prepared into medicine food homologous product, and it is not against disease, but against symptom, and has significant, stable and safe improvement effect on phlegm, throat discomfort, abdominal distension, thick and greasy tongue fur and other phlegm-related symptoms, without obvious toxic and side effects, and meets daily consumption requirements.

The invention discloses a naringin nano-silver compound which is prepared by taking silver nitrate as a silver precursor and naringin as a reducing agent through an ultrasonic reaction at the temperature of 0-80 DEG C, the molar ratio of the silver nitrate to the naringin is (4: 1)-(128: 1). According to the preparation method, a green synthesis technology is utilized, chemical reaction of plant extracts and silver nitrate is applied, and the composite nano-silver which is biologically friendly, economical and efficient is prepared.

This invention belongs to the technical field of medical gels, specifically relating to a gynecological antibacterial gel and its preparation method. The gel comprises an antibacterial phase and a probiotic phase. Through the synergistic ratio of naringin, nisin, and lauroyl arginine ethyl hydrochloride, broad-spectrum inhibition of common pathogenic bacteria is achieved. Simultaneously, the introduction of *Lactobacillus rhamnosus* metabolites and sodium hyaluronate constructs a probiotic phase, promoting probiotic colonization and the restoration of vaginal microecological balance. The gel maintains a stable pH of 4.0–4.5, exhibiting good rheological properties and retention performance. In the preparation method, each component is added stepwise, and the system temperature and stirring conditions are controlled to ensure component activity and product stability. This invention can effectively alleviate bacterial vaginosis, fungal infections, and microecological disorders, providing synergistic, safe, and gentle comprehensive care effects.

The invention discloses a method for extracting and preparing naringin from fresh pomelo fruits, and belongs to the field of natural product extraction. The method comprises the steps of compound enzymolysis, mixed resin purification, filtration, crystallization and drying, and specifically comprises the following steps: adding water into fresh pomelos, crushing the fresh pomelos into pomelo pulp, adding compound enzymes (cellulase, pectinase and xylanase), carrying out enzymolysis on the pomelo pulp and diatomite, adding chitosan after enzymolysis, carrying out flocculation and centrifugation to obtain clear liquid, and carrying out enzyme deactivation and juicing to obtain filtrate; introducing the filtrate into a mixed resin column (modified AB-8 resin and XAD-7HP resin), eluting with deionized water, ethanol with the volume fraction of 32-38% and ethanol with the volume fraction of 42-48% in sequence, and collecting ethanol eluent with the volume fraction of 42-48%; and carrying out micro-filtration and nano-filtration (the molecular weight cut-off is 280-320 Da) on the eluent, concentrating, crystallizing, and centrifugally drying to obtain a finished product. The method can effectively break a pectin colloidal network and separate polar impurities, the purity of a finished product is high, and pharmaceutical-grade requirements are met.

The invention discloses a whole-process quality transmission quality control method of a mixture capable of tonifying qi, soothing nerves and eliminating diseases. The method comprises the following steps: respectively preparing a test sample in four process stages of decoction, concentration, centrifugation and sterilization, measuring seven physical parameters including pH, refractive index, dynamic viscosity, conductivity, total amount of soluble solids, solid content and density, and constructing a physical fingerprint spectrum; the method comprises the following steps: determining the contents of nine index components including salidroside, caffeic acid, ferulic acid, specnuezhenide, naringin, hesperidin, rosmarinic acid, formononin and nobiletin by adopting an HPLC (High Performance Liquid Chromatography) method, establishing a chemical fingerprint spectrum, and calculating the transfer rate of each component in each process stage; the correlation between the physical parameters and the component transfer rate is analyzed through the matrix hotspot map, and common peaks are identified to calculate the similarity. A multi-index evaluation mode of physical fingerprint, chemical fingerprint and multi-component content determination is established, the influence of the preparation process on the overall quality of the traditional Chinese medicine can be systematically evaluated, and a scientific basis is provided for quality control in the traditional Chinese medicine production process.

The invention belongs to the technical field of biological medicines, and particularly relates to application of naringin in preparation of a medicine for preventing and / or treating ejection fraction retention type heart failure (HFpEF). A double-strike HFpEF mouse model induced by HFD (High Fat Diet) combined with L-NAME (N omega-nitro-L-arginine methyl ester) is constructed to prove that the naringin can obviously improve metabolic disorder, cardiovascular dysfunction and inflammatory injury of the HFpEF mouse and relieve myocardial hypertrophy and myocardial fibrosis of the mouse; therefore, the effect of preventing and / or treating the ejection fraction retention type heart failure can be achieved, and the naringin can be used as an active ingredient for preparing the medicine for preventing and / or treating the ejection fraction retention type heart failure.

The invention relates to the field of food, in particular to a tea product composition, a sweetening agent and application of the sweetening agent. The composition provided by the invention is obtained by performing glycosylation reaction on naringin and a tea extract, the concentration of the naringin is 1-20% (w / w); the concentration of the tea extract is 1-50% (w / w). Through naringin-polyphenol double-substrate synergistic glycosylation, a traditional bitter agent naringin is converted into a sweet taste mellow enhancing factor for the first time, and on the premise that the sweetness is not reduced and exogenous sugar is not introduced, the sensory defects that a high-power sweetening agent is thin in sweetness and poor in aftertaste are overcome; the product has the outstanding advantages of easily available raw materials, simple process, friendly label, remarkable sense improvement and the like.