Method for preparing phloretin

Abstract

The invention provides a method for preparing phloretin. The method comprises the following steps of: heating, hydrolyzing and purifying to obtain the phloretin under the action of dilute acid by using naringin dihydrochalcone. The naringin dihydrochalcone is prepared by the following method: performing catalytic hydrogenation on naringin under the medium pressure, normal temperature or heating action by using hydrogen in the presence of alkali liquor and rare metal catalyst, and collecting the naringin dihydrochalcone from the reaction system. The method is easy to operate, low in cost and high in product quality, and large-scale application of phloretin on the medicine, food and cosmetics can be well met.

Description

technical field

[0001] The invention relates to a preparation method of phloretin. Background technique

[0002] Phloretin is a dihydrochalcone compound, which is a natural active substance present in apples, pears and other fruits and various vegetables. estrogen-like activity. Dihydrochalcones have unique biological activities. Foreign researchers have long begun to study their role in health care, food additives and functional cosmetics, and have developed them by studying the relationship between compound structure and curative effect. The development of new drugs and the study of their mechanism of action and metabolic process in vivo are also in progress.

[0003] Described in the patent of Setala Kai etc. that phloretin can activate cellular protein kinase, has curative effect to cell hyperplasia, is the antimutagenic factor in food, can be used for the treatment of skin cancer and other tumors (US4565806 Composition and method for rational treatment of cancer). Z...