28 results about "Dihydrochalcone" patented technology

The invention is applicable to the technical field of biological medicines, provides application of a natural compound of a targeted colon cancer drug resistance related protein, and particularly relates to application in preparation of drugs for preventing or treating colon cancer. According to the invention, a natural small molecule compound neohesperidin dihydrochalcone targeting the colon cancer drug resistance related protein TAGLN is screened out, and a new scheme is provided for reversing colon cancer drug resistance, so that the situation that no drug is available to the target spot is solved. Secondly, the invention also provides a scheme for combined use of neohesperidin dihydrochalcone and oxaliplatin, the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, and a new choice is provided for clinical treatment of colon cancer.

The present disclosure generally relates to dihydrochalcone compounds and their use for enhancing the perception of alcohol (ethanol) in food, beverages, and other comestible compositions. In certain aspects, the disclosure provides the use of such dihydrochalcone compounds to enhance an alcoholic (ethanolic) flavor of a beverage, for example, a low-alcohol or zero-alcohol beverage. In certain other aspects, the disclosure provides low-alcohol or zero-alcohol beverages containing such dihydrochalcone compounds.

The application belongs to the technical field of biological medicine, and provides application of a natural compound targeting colon cancer drug resistance related protein, in particular, application in preparation of a drug for preventing or treating colon cancer; the application screens out a natural small-molecule compound hesperetin dihydrochalcone targeting colon cancer drug resistance related protein TAGLN, and provides a new scheme for reversing colon cancer drug resistance, so as to solve the situation that no drug is available for the target point. In addition, the application further provides a scheme in which hesperetin dihydrochalcone is combined with oxaliplatin, and the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, thereby providing a new choice for clinical treatment of colon cancer.

The present invention relates to a confectionery containing psicose. Specifically disclosed is a sugar-free confectionery composition which is a jelly confectionery wherein the confectionery comprises: from 1% to 50% by weight of psicose; and from 1% to 50% of a polyol incremental sweetener in combination with a high-potency sweetener wherein the polyol incremental sweetener is selected from the group consisting of sorbitol, maltitol, isomaltitol, mannitol, xylitol, erythritol, and lactitol, and the high-potency sweetener is selected from the group consisting of kiwifruit protein, aspartame, acesulfame K, saccharin sodium, glycyrrhizin, Alisan, cyclohexylsulfamate, stevioside, dihydrochalcone, stevioside, stevioside, glycosylated stevioside, and Momordica grosvenori, and wherein the confectionery composition has a moisture content of from 15% to 20%, and wherein the sweetener is selected from the group consisting of ketoside, aspartame, acesulfame K, saccharin sodium, glycyrrhizin, Alisan, cyclohexylsulfamate, stevioside, dihydrochalcone, stevioside, glycosylated stevioside, and Momordica grosvenori; a method of making the sugar-free confectionery composition is also disclosed. The present invention provides a low calorie, low laxative confection comprising psicose with acceptable texture, stability, clarity, flavor delivery, and shelf life.

This invention discloses the application of plant extracts in the preparation of drugs that inhibit canine parvovirus, belonging to the field of biomedical technology. The plant extract is at least one selected from phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin. Through in-depth research on various plant extracts, this invention has found that phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin all exhibit significant inhibitory effects on canine parvovirus, with soy isoflavones showing particularly outstanding effects. This research provides a novel natural drug option for the prevention and treatment of canine parvovirus. This invention not only expands the application scope of natural plant extracts in the veterinary medicine field but also provides important technical support for the development of novel, highly effective, safe, and side-effect-free drug formulations for the prevention and treatment of canine parvovirus.

A flavor composition is provided. The composition includes a dihydrochalcone selected from the group consisting of hesperetin dihydrochalcone, hesperetin dihydrochalcone 4"-beta-D-glucoside, and combinations thereof, and an aromatic ingredient selected from the group consisting of 4-hydroxy-2H-furan-5-one, ethyl furanone, maltol, furfural, 5-methylfurfural, vanillin, benzaldehyde, and combinations thereof.

The purpose of the present invention is to improve the quality of sweetness in a food or beverage containing a sweetener. According to the present invention, in a food or beverage containing a sweetener, the food or beverage contains dihydrochalcones and minerals, and the content of dihydrochalcones and minerals is adjusted to a prescribed range.

The present disclosure provides a use of a compound of Formula (I), wherein: - one of A and B is H and the other is (II); - G is R2 and E is H, -CH2-E' or (III), or G and E' are both single carbon atoms, said carbon atoms being directly linked together by a single bond, G being substituted by (IV) and E' being substituted by R6; - Re is H or OR1; - Rf is H or OR8, wherein R8 is H or C1-C12 alkyl; - each of R1, R2, R3, and R4 is independently H or C1-C12 alkyl; and - each of R5, R6, and R10 is independently H, OH, C1-C12 alkyl, or C1-C12 alkoxy, or a salt, ester, or solvate thereof, for preventing or reducing Legionella growth. Also provided is a kit comprising the compound.

A flavor composition is provided. The composition includes a dihydrochalcone selected from the group consisting of hesperetin dihydrochalcone, hesperetin dihydrochalcone 4″-beta-D-glucoside, and combinations thereof, and an aroma ingredient selected from the group consisting of furonol, ethyl furanone, maltol, furfural, 5-methyl furfural, vanillin, benzaldehyde, and combinations thereof.

The application relates to the application of natural plant extracts in the field of oral health, and particularly discloses the application of an extract of Ilex hainanensis Merr in oral health care products. The Ilex hainanensis Merr dichloromethane extract is eluted by high-concentration ethanol through a macroporous resin, and is rich in dihydrochalcone active ingredients, has significant inhibitory activity on Porphyromonas gingivalis and Fusobacterium nucleatum, and has no inhibitory effect on Streptococcus mutans, can selectively inhibit periodontal pathogenic bacteria without destroying the oral microecological balance, and is suitable for preparing toothpaste, mouthwash, oral spray and other oral health care products.

A flavor composition is provided. The composition includes at least one triterpenoid compound selected from the group consisting of pterocaryoside B, pterocaryoside A, cyclocarioside K and combinations thereof; and at least one sweetness modifier selected from the group consisting of steviol glycosides, mogrosides, dihydrochalcones, sweet proteins and combinations thereof.

The invention discloses a leucaena leucocephala-sourced dihydrochalcone compound, a preparation method thereof and application of the dihydrochalcone compound as a tyrosinase inhibitor. According to the invention, the tyrosinase inhibitor dihydrochalcone compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxychalcone is extracted and separated from the leucaena leucocephala plant, the structural formula of the compound is as shown in the formula (I), the plant material is rich in source and is a renewable tissue part, and not only is the economic benefit good, but also the environment-friendly effect is achieved. Pharmacological experiments show that the tyrosinase inhibitory activity of the compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxycholone is stronger than that of kojic acid, and the compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxycholone) is expected to be further developed into a new whitening cosmetic synergist, a drug for treating pigmentation dermatosis, an insect control agent or a food preservative and the like, and has a good prospect.

Provided herein is a method of increasing production of a dihydrodiphenylpropanoid derivative compound (e.g., dihydrostilbenoid or dihydrochalcone compound) in a recombinant host cell. The method comprising: reducing or eliminating expression of a gene encoding a double-bond reductase polypeptide or activity of the double-bond reductase polypeptide encoded thereby; expressing a recombinant gene encoding a double-bond reductase selected from the group consisting of a first polypeptide, second polypeptide, third polypeptide, and combinations thereof. The first polypeptide comprises an amino acid sequence having at least 90% identity to the amino acid sequence as set forth in SEQ ID NO: 3, the second polypeptide comprises an amino acid sequence having at least 90% identity to the amino acid sequence as set forth in SEQ ID NO: 5, and the third polypeptide comprises an amino acid sequence having at least 90% identity to the amino acid sequence as set forth in SEQ ID NO: 7.

A flavor composition is provided. The composition includes a dihydrochalcone selected from the group consisting of hesperetin dihydrochalcone, hesperetin dihydrochalcone 4″-beta-D-glucoside, and combinations thereof, and an aroma ingredient selected from the group consisting of furonol, ethyl furanone, maltol, furfural, 5-methyl furfural, vanillin, benzaldehyde, and combinations thereof.

A perfume composition is provided. The present invention relates to a composition comprising rutin and a sweetness modifier selected from the group consisting of mogroside, dihydrochalcone, hesperidin 3-acetate, brazilin, thaumatin, and combinations thereof.

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a method for detecting the content of effective components of pseudo-ginseng and dragon's blood capsules. The invention provides a method for detecting the content of effective components in a pseudo-ginseng and dragon's blood capsule, which comprises the following steps: a, preparing a test solution: weighing pseudo-ginseng and dragon's blood capsule powder, adding methanol, performing ultrasonic treatment, and filtering to obtain the test solution; b, preparation of a reference substance solution: precisely weighing a ginsenoside Re reference substance, and adding methanol to dissolve the ginsenoside Re reference substance; the preparation method comprises the following steps: precisely weighing a proper amount of reference substances such as resveratrol, 4, 4-dihydroxy-2, 6-dimethoxy dihydrochalcone, loureirin A, loureirin B, loureirin C and loureirin D, and adding methanol for dissolving, thereby obtaining the resveratrol, 4, 4-dihydroxy-2, 6-dimethoxy dihydrochalcone and loureirin A; c, preparation of a reference substance solution: weighing the panax notoginseng total saponin reference extract, and adding methanol to dissolve the panax notoginseng total saponin reference extract to obtain the reference substance solution; and d, measuring and calculating the content. The method disclosed by the invention is high in accuracy, good in linearity, high in precision, good in separation degree and relatively good in repeatability.

This invention discloses a dihydrochalcone-based oral spray and its preparation method, belonging to the field of oral pharmaceutical formulations. The spray uses 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-1-propanone and 2',6'-dihydroxy-3',4'-dimethoxydihydrochalcone, isolated and purified from *Sarcandra glabra*, as active ingredients. It is solubilized using a medium-chain triglyceride / polyoxyethylene hydrogenated castor oil / propylene glycol self-microemulsification delivery system, and hydroxypropyl methylcellulose is introduced to enhance mucosal adhesion. This spray can spontaneously form nanoemulsion droplets in oral saliva, selectively inhibiting *Porphyromonas gingivalis* and *Fusobacterium nucleatum*, and is suitable for adjunctive treatment of gingivitis and periodontitis.

The application discloses a 3'-geranyl-4,2',4',6'-tetrahydroxy dihydrochalcone against gram-positive bacteria, and a chemical structural formula of the dihydrochalcone is shown as formula (I). The application further provides a preparation method and application of the dihydrochalcone derivative. The 3'-geranyl-4,2',4',6'-tetrahydroxy dihydrochalcone has significant antibacterial activity against gram-positive bacteria, MRSA retention bacteria activity, and can significantly inhibit the formation of gram-positive bacterial biofilm.

The present invention discloses an aromatic composition comprising: (a) hesperidin dihydrochalcone or a salt thereof; and (b) a high-fructose corn syrup (HFCS) that provides high sweetness but low calorie intake.

The invention discloses a dihydrochalcone compound Invoucrasin H as well as a preparation method and application of the dihydrochalcone compound Invoucrasin H. The Invoucrasin H is obtained by being separated from a leguminosae seguinea plant ephedra cochinchinensis. Researches on an in-vivo lipopolysaccharide-induced acute lung injury mouse model and an in-vitro human bronchial epithelial cell inflammation model show that the compound can significantly reduce the levels of inflammatory factors IL-6, IL-1beta and TNF-alpha, and alleviate lung tissue inflammatory response and pathological injury. The invention also provides an application of the Invoucrasin H in preparation of medicines for preventing and treating acute lung injury and related inflammatory lung diseases. The invention provides a new natural small molecule candidate drug for treating acute lung injury.

A flavor composition is provided. The composition includes advantame; and at least one taste modifier selected from the group consisting of i) a sweetness modifier comprising a dihydrochalcone, ii) a positive allosteric modulator of the human sweet taste receptor, and iii) combinations thereof.

The application discloses a preparation method of a new hesperidine dihydrochalcone-propylene aldehyde adduct, which comprises the following steps: adding new hesperidine dihydrochalcone into methanol to obtain mother liquor A; adding propylene aldehyde into methanol to obtain mother liquor B; mixing the mother liquor A and the mother liquor B, adding phosphate buffer solution, adjusting pH, heating and reacting, and filtering to obtain the new hesperidine dihydrochalcone-propylene aldehyde adduct. The new hesperidine dihydrochalcone-propylene aldehyde adduct prepared by the application can be used as a standard product of a propylene aldehyde reaction product in food detection, and the reaction system can generate the adduct within 5 min, and the clearance rate can reach 95.99% within 40 min. The new hesperidine dihydrochalcone-propylene aldehyde adduct can also be applied to qualitative determination of the propylene aldehyde adduct in rapid food detection. The preparation is simple, low in cost, efficient, free of consumption of a chromogenic agent, high in sample recovery rate, can effectively capture propylene aldehyde, and can control and effectively reduce the content of propylene aldehyde in food.

Methods of isolating dihydrochalcone compounds of Formula (I) from Balanophora harlandii are provided herein. Compositions and consumables comprising at least one sweetener and at least one dihydrochalcone compound described herein are also provided. Methods of enhancing the sweetness of a consumable, methods of making a consumable taste more like a sucrose-sweetened consumable and methods of preparing consumables are also detailed herein.

The invention discloses glabrous sarcandra herb compound antibacterial gel as well as a preparation method and application thereof, and belongs to the technical field of oral medicine preparations, the gel is prepared from the following components in parts by weight: 2-8 parts of 90% ethanol eluate of glabrous sarcandra herb, 0.5-2 parts of eugenol, 0.3-1 part of gallic acid, 1-2 parts of carbomer 940, triethanolamine for adjusting the pH value to 6.5-7.0, 15-25 parts of glycerol and the balance of purified water. The 90% ethanol eluate of sarcandra glabra is rich in dihydrochalcone compounds and has remarkable inhibitory activity on porphyromonas gingivalis and fusobacterium nucleatum, the three components are compounded to generate a synergistic antibacterial effect, the 90% ethanol eluate of sarcandra glabra has no obvious inhibition on streptococcus mutans, and the selective effect on periodontal pathogenic bacteria is achieved.

The application discloses a dihydrochalcone glycoside compound in traditional Chinese medicine bryonia and a preparation method and application thereof. The preparation method is as follows: taking cup-stem bryonia as initial raw material, taking the aboveground part, crushing, extracting at room temperature with 95% ethanol, concentrating the extract to obtain an extract; dispersing the extract in water, sequentially extracting with petroleum ether, ethyl acetate and n-butanol, recovering the solvents to obtain a petroleum ether part, an ethyl acetate part and an n-butanol part; dissolving the ethyl acetate part extract with 10% ethanol, separating by polyamide column chromatography to obtain three parts A, B and C; and separating the B part by polyamide column chromatography with (ethyl acetate: ethanol: glacial acetic acid: water = 10:5:1:1) to obtain compounds 1, 2 and 3, i.e. dihydrochalcone glycoside compounds. The preparation process is simple, the extraction rate is high, and the development and utilization of the traditional Chinese medicine bryonia are facilitated; the compounds have antioxidant, antitumor and antibacterial activities, and can be applied to antioxidant and inhibition of proliferation of hepatoma cells.

The present disclosure relates generally to certain flavanone compounds and the use of such compounds to modify the flavor or taste of ingestible compositions. These flavanone compounds include 8-methylnaringenin (5, 7, 4 '-trihydroxy-8-methylflavanone), 5, 3'-dihydroxy-7, 4 '-dimethoxyflavanone, 5-hydroxy-7, 3', 4 '-trimethoxyflavanone, 5, 4'-dihydroxy-7, 3 '-dimethoxyflavanone, or any combination thereof. In some embodiments, the use of these flavanone compounds includes use to enhance sweetness, use to reduce off-taste of high intensity sweeteners, use to enhance salty taste, use to enhance umami or rich taste, or any combination thereof. In certain embodiments, these compounds are used in combination with other natural taste modifiers (e.g., flavonoids or dihydrochalcones). In certain forms, the present disclosure provides ingestible compositions comprising such flavanone compounds. In some related forms, the ingestible composition is a variety of flavored products or is included in a variety of flavored products, such as a food product, a beverage product, a pharmaceutical product, an oral care product, or an animal feed product.

The present invention concerns a flavouring composition comprising hesperetin and hesperetin dihydrochalcone for improving the taste profile in a preparation. Furthermore, the present invention relates to preparations having a balanced taste profile as well as a method for improving the taste profile of a preparation.

The invention discloses an edible compound enzyme as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing fresh leaves of moringa oleifera and fresh leaves of lithocarpus litseifolius, and then carrying out composite enzymolysis pretreatment; then adding malt extract as a fermentation accelerant, and sequentially carrying out high-frequency sound wave fermentation and low-frequency sound wave auxiliary fermentation; and finally, carrying out sterilization and low-temperature concentration on the fermentation liquor to obtain the edible compound enzyme. According to the method, through cooperation of enzymolysis, a specific fermentation accelerant and two-stage variable-frequency sound wave auxiliary fermentation, characteristic active ingredients such as moringa oleifera flavone and Lithocarpus litseifolius fresh leaf dihydrochalcone (such as phlorizin) can be efficiently enriched, and the fermentation activity of an enzyme product is remarkably improved. The enzyme fermentation stock solution prepared by the method can be directly diluted with warm water for drinking, is harmonious in taste and rich in nutrition, and meets the requirements of ready-to-eat enzyme products; meanwhile, the compound can also be used as a functional fermentation raw material to be applied to baking food.