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Integrated active flux microfluidic devices and methods

InactiveUS6767706B2Rapid and complete exposureQuick and accurate and inexpensive analysisBioreactor/fermenter combinationsFlow mixersAntigenHybridization probe
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.
Owner:CALIFORNIA INST OF TECH

System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology

The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.
Owner:NATERA

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.
Owner:CALIFORNIA INST OF TECH

Method and apparatus for selective engagement of shelf divider structures within a shelf management system

Apparatus and method for selectively engaging and securing an array of shelf dividers to a mounting device which is securable to a display shelf. In the first form a divider is characterized by a divider structure having an elongated vertical wall and elongated horizontal base that operates to divide, organize and support the displayed merchandise. A resilient latch located on the underside of the base of the divider structure selectively engages and secures the divider structure onto a mounting device comprising a receiving member running longitudinally along the length of the surface of the mounting device which is securable along the front edge of a display shelf. The latch and the receiving member each comprise reciprocating (i.e. complementary) protrusions to allow the cooperative engagement of the divider structure and mounting device, thus locking the divider member to and unlocking the divider member from the mounting device to permit the repositioning of the display as desired without necessitating removal of the merchandise from the display. In addition when the divider structure and mounting device are fully engaged, a second protrusion on the underside of the divider member cooperates with a flange or lip on the mounting device to prevent lateral movement of the divider structure and maintain the position of the divider perpendicular to the mounting device and the front edge of the shelf. In a second embodiment, the divider structure comprises a pusher track and a spring urged pusher assembly to automatically push merchandise to the front of the shelf. Another embodiment comprises a divider base without a vertical divider wall, and with or without a pusher track and spring urged pusher assembly, thus pushers and dividers can be used in various convenient combinations within a shelf management system.
Owner:MERIT JO A & WILLIAM
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