240 results about "Glucose sensors" patented technology

The object of the present invention is to provide a flexible OECT non-enzymatic glucose sensor and a preparation method thereof, belonging to the technical field of glucose electrochemical sensors. The sensor uses a chemically modified laser-induced graphene (LIG) electrode as the gate, and gold nanoclusters (AuNC) are modified on the LIG through controllable in-situ electrochemical reduction; at the same time, by utilizing the pH-dependent conductivity of PEDOT:PSS, the self-calibration of the sensor of the present invention to the pH change of human sweat is realized, thereby reducing interference and improving the measurement accuracy. The flexible non-enzymatic glucose sensor designed by the present invention has the advantages of high detection sensitivity, low detection limit, excellent long-term stability, and being unaffected by pH value fluctuations, and can be widely applied to the field of wearable electronics.

The invention discloses a sweat uric acid and glucose sensor based on a carbon nanotube (CNT) enhanced electrochemical platform, and aims to solve the sensitivity challenge of low-concentration biomarker detection in sweat. The enzyme is covalently immobilized on the CNT through an EDC / NHS chemical method, so that the catalytic efficiency, the electron transfer speed and the sensor stability are remarkably improved, and the ultralow detection lower limit of uric acid and glucose is realized. According to the device, uric acid, glucose and pH sensing functions are integrated on a single wearable platform, efficient flowing and rapid updating of sweat are ensured through a radiation symmetry microfluid design optimized through finite element analysis, and real-time biomarker monitoring is supported. The material innovation (such as CNT-enzyme complex) and fluid dynamics optimization of the invention overcome the key problem in the field of wearable biosensing, and provide an extensible solution for the next generation of non-invasive health monitoring.

The invention discloses a preparation method and application of a glucose sensor based on an acupuncture needle, the sensor is prepared based on a specific structural design and a molecular recognition mechanism by taking the acupuncture needle as a substrate, and high-specificity and high-sensitivity detection of glucose concentration is realized through drain current change. According to the present invention, the biosensor has the ultra-wide dynamic detection range (0-40 mmol.L <-1 >), covers the clinical range from hypoglycemia to severe hyperglycemia, has the low detection limit of 54 mol.L <-1 >, has excellent grid regulation and control ability, shows the significant on-off ratio and the rapid response characteristic during the detection process, and meets the requirements of the biosensor on sensitivity and real-time performance; and the device has quick response capability to grid voltage change, so that the device has good stability and repeatability under repeated operation, and a direction and a basis can be provided for the development of a blood glucose monitoring technology with continuous, real-time and accurate characteristics.

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are provided. The data can be displayed on a hand-held display device having a display such as a key fob device including a user interface, such as an LCD and one or more buttons allows a user to view data, and a physical connector, such as USB port.

An analyte assessment system includes an analyte sensor, a remote device, and a software application. The remote device is configured to retrieve sensor data of a patient from the analyte sensor. The software application is configured to receive an order for analyte assessment associated with an electronic medical record (EMR) of the patient, generate or retrieve a unique identifier associated with the order, authenticate the unique identifier with the remote device, activate the analyte sensor based on the unique identifier, retrieve sensor data from the remote device, generate a report, and upload the report to the EMR of the patient. Advantageously the system can streamline requests and delivery of analyte reports for third parties, reduce in-person patient interactions and time delays, reduce third party effort, increase security and integrity of patient data, update an EMR of the patient, and operate in a blinded mode for unbiased patient analyte assessment.

The invention aims to provide a flexible OECT non-enzymatic glucose sensor and a preparation method thereof, and belongs to the technical field of glucose electrochemical sensors. According to the sensor, a chemically modified laser-induced graphene (LIG) electrode is used as a grid electrode, and gold nanoclusters (AuNC) are modified on LIG through controllable in-situ electrochemical reduction; meanwhile, the pH-dependent conductivity of PEDOT: PSS is utilized to realize the self-calibration of the sensor to the pH change of human sweat, so that the interference is reduced, and the measurement accuracy is improved. The flexible non-enzymatic glucose sensor designed by the invention has the advantages of high detection sensitivity, low detection limit, excellent long-term stability, no influence of pH value fluctuation and the like, and can be widely applied to the field of wearable electronics.

The invention relates to the technical field of glucose sensors, in particular to a direct electron transfer type sensor electrode mediated by a carbon nanomaterial, a preparation method of the direct electron transfer type sensor electrode and a glucose biosensor with the sensor electrode. The sensor electrode comprises: a base electrode having an electrode working area; the nanometer conducting layer is arranged on the electrode working area, and the nanometer conducting layer comprises a carbon nanometer material; and the analyte detection layer is arranged on the nano conductive layer, and the analyte detection layer comprises glucose dehydrogenase.

The invention provides an enzyme protective agent for a continuous glucose sensor and the continuous glucose sensor, the enzyme protective agent comprises the following components: poloxamer and a zwitterionic polymer, and the mass percent concentration of the poloxamer is 0.1%-2%, and the mass percent concentration of the zwitterionic polymer is 0.5%-5%. By adopting the technical scheme provided by the invention, the poloxamer and the zwitterionic polymer are introduced, so that an enzyme layer coating process can be optimized, a coffee ring effect can be inhibited, and the consistency and monitoring accuracy of the sensor can be improved; and on the premise of keeping the signal transmission performance of the sensor unchanged, the activity and long-term stability of the biological enzyme preparation in the production, storage, transportation and use processes are remarkably improved.

The invention relates to a continuous blood glucose monitoring circuit, which takes a 32-bit ARM (Advanced RISC Machines) processor of an STM32F407 singlechip as a main controller and an ADS131A04 high-precision synchronous sampling ADC (Analog to Digital Converter) chip as a core, comprises a main control circuit, a signal acquisition circuit, a constant potential circuit, a constant current circuit and a power supply circuit, is connected with a blood glucose sensor by adopting an FPC (Flexible Printed Circuit) connector, and is used for continuously monitoring blood glucose under the condition of constant current stimulation and constant voltage. The output signal of the sensor is collected in real time, and after the main control processes the data, the collected data is stored in the MicroSD card and is displayed on the screen at the same time. Intelligent control over the continuous blood glucose monitoring system is achieved by means of the high running speed and rich interface resources of the STM32F407; the multi-channel design can monitor relevant ion concentration parameters while collecting blood glucose signals, and can accurately monitor the blood glucose and the relevant ion concentration of a human body and correct the blood glucose signals in cooperation with a blood glucose sensor.

A method may comprise (a) inserting an insulin delivery device subcutaneously into a body of a subject, which comprises an amperometric glucose sensor comprising an electrode layer comprising an indicating electrode and underlying a redox-catalytic layer comprising a redox mediator; (b) using said insulin delivery device to deliver an insulin formulation (e.g., comprising a phenol or cresol excipient) subcutaneously to said subject; and (c) using said amperometric glucose sensor to measure a subcutaneous glucose concentration, which comprises using said redox-catalytic layer to allow electron transfer from subcutaneous glucose to said indicating electrode sufficient to cause a response of said amperometric glucose sensor at an applied bias potential of no more than +250 millivolts, wherein (b) and (c) are performed at the same time for at least one hour, while maintaining a sensor sensitivity of at least 50% of an initial sensor sensitivity for up to one hour.

A mathematical model of type 1 diabetes (T1D) patient decision-making can be used to simulate, in silico, realistic glucose / insulin dynamics, for several days, in a variety of subjects who take therapeutic actions (e.g. insulin dosing) driven by either self-monitoring blood glucose (SMBG) or continuous glucose monitoring (CGM). The decision-making (DM) model can simulate real-life situations and everyday patient behaviors. Accurate submodels of SMBG and CGM measurement errors are incorporated in the comprehensive DM model. The DM model accounts for common errors the patients are used to doing in their diabetes management, such as miscalculations of meal carbohydrate content, early / delayed insulin administrations and missed insulin boluses. The DM model can be used to assess in silico if / when CGM can safely substitute SMBG in T1D management, to develop and test guidelines for CGM driven insulin dosing, to optimize and individualize off-line insulin therapies and to develop and test decision support systems.

The invention is applicable to the technical field of material preparation and electrochemical sensing, and discloses a graphdiyne oxide gold nanoparticle composite electrode, a preparation method and application of the graphdiyne oxide gold nanoparticle composite electrode in a non-enzymatic glucose electrochemical sensor. Preparing the prepared graphdiyne oxide into an aqueous dispersion, taking carbon cloth as a substrate electrode, soaking the carbon cloth in the graphdiyne oxide dispersion after ethanol soaking, drying and surface treatment, drying, then soaking the carbon cloth in the prepared gold nanoparticle solution, and heating and drying to obtain the graphdiyne oxide gold nanoparticle composite electrode; the graphdiyne oxide and the gold nanoparticles are uniformly distributed on the surface of the carbon cloth. Due to the fact that rich oxygen-containing groups on the graphdiyne oxide can cooperate with the gold nanoparticles to promote catalytic oxidation of glucose, the non-enzymatic glucose electrochemical sensor prepared based on the electrode material has high catalytic activity on glucose and shows high sensitivity, selectivity and stability.

The invention belongs to the technical field of CGM sensors, and particularly relates to a CGM electrode sensor and a preparation method thereof.The preparation method comprises the following steps that three sets of stainless steel microneedle arrays are prepared from a stainless steel substrate and serve as a counter electrode, a reference electrode and a working electrode respectively; mechanically polishing the stainless steel microneedle array, and performing composite pickling activation; after surface pretreatment, a sol-gel deposition aluminum oxide layer is adopted; preparing a gold plating solution, and plating gold on the stainless steel microneedle array deposited with the aluminum oxide layer by adopting two-stage pulse electroplating; the working electrode is prepared by PMMA coating, adhesion layer construction, glucose oxidase immobilization and limiting layer construction; the counter electrode, the reference electrode and the working electrode are respectively embedded into the substrate to form the microneedle array electrode sensor with a three-electrode system. Based on a nickel-free direct gold plating process, good uniformity, strong binding force and lower cost after gold plating can be realized, so that the stability of the continuous glucose sensor in use is improved.

The present disclosure presents glucose monitoring systems and methods. One such system comprises a glucose monitoring sensor having at least a counter electrode, a reference electrode, and a working electrode; and a silicon-carbide-silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane contacting the working electrode. The system further includes a glucose oxidase enzyme solution contacting the silicon-carbide-silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane, wherein a conductive polymer membrane assists in binding the glucose oxidase enzyme composition with the silicon-carbide-silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane. Other systems and methods are also provided.

Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and / or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells.

The invention provides an energy complementation guidance method for endurance sports and related electronic equipment, and the energy complementation guidance method comprises the steps: receiving measured glucose data of a first time period from a glucose sensor, the measured glucose data reflecting the glucose level of an endurance athlete wearing the glucose sensor; receiving measured ketone body data from the ketone body sensor for a first period of time, the measured ketone body data reflecting a ketone body level of the endurance athlete wearing the ketone body sensor; predicting an energy result based on the measured glucose data and the measured ketone body data, the energy result representing whether the endurance athlete is energy depleted after a second time period after the first time period; and transmitting energy complementation information based on the energy result. Therefore, the accuracy of identifying the energy complementation opportunity can be improved.

The utility model discloses a temperature self-correcting implantable blood glucose sensor. The sensor mainly comprises a bin body, a power supply, a main board, a blood glucose processing module, a temperature correcting module, a Bluetooth receiving and transmitting module and a sensor probe module. The sensor probe module comprises a temperature detection electrode and a blood glucose detection electrode. Wherein the temperature detection electrode is an integrated electrode based on a thermistor, is attached to the surface of the blood glucose detection electrode and is used for detecting and sensing the real-time temperature of an implantation part, and the temperature change is fed back to the blood glucose detection module for correction, so that the measurement accuracy is improved. The device has the advantages of simple structure, high measurement accuracy, no environmental influence and the like, and is suitable for improving the long-term working stability of implantable blood glucose measurement equipment and the like.

The application discloses a kind of nickel-cobalt bimetallic enzyme-free glucose sensor materials and preparation method thereof, sensor;The nickel-cobalt bimetallic enzyme-free glucose sensor material is the composite material that nickel-cobalt bimetallic organic framework material is modified by nano silver particle;Wherein, the mole ratio of nickel-cobalt bimetallic organic framework material and nano silver particle substance in the composite material is 0.1-1.0:1;The sensor material is the composite material that nano silver particle is modified to nickel-cobalt bimetallic organic framework material, it not only has the advantage that bimetallic organic framework material specific surface area is big, more under the modification of silver particle, make nickel-cobalt bimetallic organic framework material have more excellent conductivity, so as to be used as enzyme-free glucose sensor material, sensor has higher sensitivity and reaction speed, so as to be more conducive to the large-scale application of enzyme-free glucose sensor.

This invention pertains to the field of glucose detection and discloses a copper-based MOF nanofiber membrane, its preparation method, and its application. The copper-based MOF nanofiber membrane is prepared by a method comprising the following steps: (1) adding a polyvinyl alcohol solution to a copper acetate solution to form a spinning solution; (2) electrospinning the spinning solution to obtain a copper-based nanofiber membrane; (3) calcining the copper-based nanofiber membrane in an air atmosphere to obtain a copper oxide fiber membrane; (4) mixing the copper oxide fiber membrane with an organic ligand, adding a solvent, and performing a hydrothermal reaction to obtain a copper-based MOF nanofiber membrane. The copper-based MOF nanofiber membrane prepared by this invention, as an electrode material for an enzyme-free glucose sensor, can improve conductivity, sensitivity, and anti-interference performance. Furthermore, the preparation method is simple and can be mass-produced.

A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and / or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

The present invention belongs to the field of electrochemical biosensor technology, and discloses a non-enzyme glucose sensor electrode based on CuCo bimetallic organic framework material and its preparation and application. The electrode includes a foam copper substrate and a multi-walled carbon nanotube material (MWCNTs), a nanogold material and a CuCo bimetallic organic framework material sequentially loaded on the surface of the foam copper substrate. Its preparation method includes the steps of: mixing an aqueous solution of a divalent copper salt and a divalent cobalt salt and a dimethylformamide solution of trimesic acid, performing a hydrothermal reaction to prepare a CuCo bimetallic organic framework material (CuCo‑BTC), sequentially coating a multi-walled carbon nanotube (MWCNT) dispersion, a nanogold dispersion and a CuCo bimetallic organic framework material (CuCo‑BTC) dispersion on a foam copper (CF) surface to obtain a non-enzyme glucose sensor electrode (CuCo‑BTC / Au / MWCNT / CF). The non-enzyme glucose sensor prepared by the present invention has a wide detection range, high sensitivity, and has good anti-interference performance for uric acid, dopamine, ascorbic acid and cysteine.

A device for measuring and monitoring diabetes, consisting of a system-on-chip for real-time processing of sensor data, several sensors connected to the system-on-chip, including a blood glucose sensor, a heart rate sensor and a blood pressure sensor, a machine learning model implemented on the system-on-chip for analyzing the sensor data and generating a diabetes risk score, and a memory buffer within the system-on-chip for storing sensor data for trend analysis and improved prediction accuracy.

An insulin delivery device includes an insulin injection device in communication with a controller for controlling the insulin injection device. The controller is configured to receive a heart signal from one or more heart sensors, and a blood glucose signal from one or more blood glucose sensors. The controller is further configured to analyze changes in the heart rhythm of the subject based on the heart signal and determine, based on the changes in the heart rhythm and the blood glucose signal, whether the subject is and / or will be experiencing an adverse event. Upon determination that the subject is or will be experiencing an adverse event, the controller determines one or more parameters of delivery of insulin to be delivered to the subject. Finally, the controller is configured to control the injection device to deliver insulin to the subject in accordance with the determined one or more parameters of delivery.

The invention belongs to the technical field of advanced materials and glucose detection, and relates to a 2D-MOF and MXene composite material, a printing type enzyme-free glucose sensor as well as a preparation method and application of the printing type enzyme-free glucose sensor. The preparation method of the composite material comprises the following steps: carrying out amination modification treatment on the MXene material; the MXene material subjected to amination modification treatment, nickel salt, BPY, TCPP and PVP are added into a mixed solvent of ethyl alcohol and DMF to be evenly mixed, and then a solvothermal reaction is conducted. The composite material has high catalytic activity, excellent conductivity and good dispersity, can be firmly attached to a flexible substrate, is high in stability, and can realize rapid and repetitive detection of glucose. The material can be prepared into conductive ink with good rheological property, is suitable for a printing process, can be used for preparing a wearable enzyme-free glucose sensor with high sensitivity and interference resistance, and has large-scale low-cost production potential.

A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.

The present application relates to the technical field of biosensor, especially to a glucose sensor based on composite film and a preparation method thereof, after fixing layered MoS2 semiconductor material on a substrate, the present application continues to prepare ion gel film on the substrate, then modifies glucose oxidase on the surface of the ion gel film, after incubation and fixation, modifies a layer of Nafion film on the surface of the ion gel film, because glucose oxidase oxidizes and decomposes glucose to generate protons, with the selective proton passing effect of the Nafion film, the protons pass through the Nafion film to the porous network structure formed by the ion gel film and the layered MoS2 semiconductor material, and cooperate with the cations in the ion gel film to attract more carriers, and form a double-layer structure on the surface of MoS2, cooperate with the current multiplication effect, improve the transmission efficiency of the carriers, and improve the sensitivity of the sensor.

The present invention generally relates to implantable continuous blood glucose measurement technology. In particular, the present invention relates to an implantable continuous blood glucose measurement device for continuously measuring blood glucose in the body of a user, in which an oscillator for generating a variable frequency output signal corresponding to a voltage or current applied to both ends thereof is connected to a glucose fuel cell for generating electrical energy by glucose in the body, comprises an LED element, which is turned on or off by the output signal of the oscillator, or an antenna for wirelessly transmitting the output signal of the oscillator. The present invention has the advantage that blood glucose can be continuously measured in a state in which a blood glucose sensor is implanted in the body, without having to replace same.