418 results about "Glucose sensors" patented technology

Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and / or fully automated.

The invention discloses a low-trigger-potential electrochemical luminescence enzyme biosensor for detecting glucose and a construction method and application thereof, the sensor comprises a three-electrode system formed by a working electrode, a reference electrode and a counter electrode, and a liquid to be detected contains luminol; the working electrode is a VMSF modified electrode of confined gold-palladium nanoparticles and is obtained by covalently immobilizing glucose oxidase. Luminol and glucose oxidase are respectively used as an electrochemical luminescence signal molecule and a specific recognition element; by combining the efficient and specific catalytic activity of natural enzyme, the efficient catalytic activity of gold-palladium nanoparticles on luminol electrochemical luminescence and the anti-pollution capacity of a vertical ordered mesoporous silica film, the low-trigger-potential electrochemical luminescence enzyme biosensor without an exogenous co-reactant is constructed; the method has the characteristics of high sensitivity, wide detection linear range and low detection limit, and has great application potential in constructing a portable glucose sensor for diagnosing and monitoring diabetes mellitus.

Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and / or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

In some examples, a system includes a glucose sensor configured to generate a signal indicative of a blood glucose level of a patient, a medical device configured to deliver insulin to the patient, a peritoneal dialysis (PD) device, and control circuitry. The control circuitry is configured to control the PD device to deliver PD therapy to a patient during a PD cycle, determine a blood glucose level of the patient during the PD cycle based on a signal from the glucose sensor, determine that the blood glucose level is greater than or equal to a predetermined blood glucose level threshold, and control the medical device to deliver insulin to the patient in response to determining the blood glucose level is greater than or equal to the predetermined blood glucose level threshold.

The object of the present invention is to provide a flexible OECT non-enzymatic glucose sensor and a preparation method thereof, belonging to the technical field of glucose electrochemical sensors. The sensor uses a chemically modified laser-induced graphene (LIG) electrode as the gate, and gold nanoclusters (AuNC) are modified on the LIG through controllable in-situ electrochemical reduction; at the same time, by utilizing the pH-dependent conductivity of PEDOT:PSS, the self-calibration of the sensor of the present invention to the pH change of human sweat is realized, thereby reducing interference and improving the measurement accuracy. The flexible non-enzymatic glucose sensor designed by the present invention has the advantages of high detection sensitivity, low detection limit, excellent long-term stability, and being unaffected by pH value fluctuations, and can be widely applied to the field of wearable electronics.

The invention discloses a sweat uric acid and glucose sensor based on a carbon nanotube (CNT) enhanced electrochemical platform, and aims to solve the sensitivity challenge of low-concentration biomarker detection in sweat. The enzyme is covalently immobilized on the CNT through an EDC / NHS chemical method, so that the catalytic efficiency, the electron transfer speed and the sensor stability are remarkably improved, and the ultralow detection lower limit of uric acid and glucose is realized. According to the device, uric acid, glucose and pH sensing functions are integrated on a single wearable platform, efficient flowing and rapid updating of sweat are ensured through a radiation symmetry microfluid design optimized through finite element analysis, and real-time biomarker monitoring is supported. The material innovation (such as CNT-enzyme complex) and fluid dynamics optimization of the invention overcome the key problem in the field of wearable biosensing, and provide an extensible solution for the next generation of non-invasive health monitoring.

The invention relates to the field of glucose sensors, in particular to a rock salt type high-entropy oxide for enzyme-free glucose sensor active substances. The high-entropy oxide is of a single-phase rock salt structure, the molecular formula is MO, and M in the formula is composed of five transition metal elements including Cu, Co, Ni and any two of Mn, Zn, Mg and Fe. According to the preparation method, Mg, Co, Ni, Cu and Zn are preferably selected, and the (MgCoNiCuZn) O high-entropy oxide is prepared through a sol-gel and roasting method. The high-entropy oxide is selected as an active substance to prepare the glucose sensor, and the glucose sensing performance of the glucose sensor is as follows: the sensitivity in a linear range of 5-400 [mu] M is 108.14 [mu] AmM <-1 > cm <-2 >, the sensitivity in a linear range of 400-1500 [mu] M is 41.84 [mu] AmM <-1 > cm <-2 >, and the lower detection limit is 0.3 [mu] M. The high-entropy oxide is applied to the enzyme-free glucose sensor, and the electrode material is simple to prepare, low in cost, high in sensitivity, wide in linear range and good in application prospect.

The invention discloses a preparation method and application of a glucose sensor based on an acupuncture needle, the sensor is prepared based on a specific structural design and a molecular recognition mechanism by taking the acupuncture needle as a substrate, and high-specificity and high-sensitivity detection of glucose concentration is realized through drain current change. According to the present invention, the biosensor has the ultra-wide dynamic detection range (0-40 mmol.L <-1 >), covers the clinical range from hypoglycemia to severe hyperglycemia, has the low detection limit of 54 mol.L <-1 >, has excellent grid regulation and control ability, shows the significant on-off ratio and the rapid response characteristic during the detection process, and meets the requirements of the biosensor on sensitivity and real-time performance; and the device has quick response capability to grid voltage change, so that the device has good stability and repeatability under repeated operation, and a direction and a basis can be provided for the development of a blood glucose monitoring technology with continuous, real-time and accurate characteristics.

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are provided. The data can be displayed on a hand-held display device having a display such as a key fob device including a user interface, such as an LCD and one or more buttons allows a user to view data, and a physical connector, such as USB port.

The invention provides a non-invasive high-precision blood glucose sensor and a preparation method thereof. The blood glucose sensor comprises two symmetrical sensing areas prepared on a flexible substrate layer, each sensing area comprises a glucose sensor working electrode, a glucose sensor auxiliary electrode / reference electrode, a sodium ion sensor working electrode, a pH sensor working electrode and a sodium ion / pH sensor common reference electrode; the electrodes are distributed in an axial symmetry mode along the central axis of the sensor plane and are prepared through silk-screen printing. Due to the symmetrical structural design of the blood glucose sensor, the electrode polarity of the extraction electrode can be exchanged during two adjacent times of extraction so as to reduce electrode consumption and skin stimulation, the change of the extraction amount of intercellular fluid can be corrected by the integrated sodium ion and pH sensor, and therefore high-precision blood glucose monitoring is achieved.

An analyte assessment system includes an analyte sensor, a remote device, and a software application. The remote device is configured to retrieve sensor data of a patient from the analyte sensor. The software application is configured to receive an order for analyte assessment associated with an electronic medical record (EMR) of the patient, generate or retrieve a unique identifier associated with the order, authenticate the unique identifier with the remote device, activate the analyte sensor based on the unique identifier, retrieve sensor data from the remote device, generate a report, and upload the report to the EMR of the patient. Advantageously the system can streamline requests and delivery of analyte reports for third parties, reduce in-person patient interactions and time delays, reduce third party effort, increase security and integrity of patient data, update an EMR of the patient, and operate in a blinded mode for unbiased patient analyte assessment.

The invention aims to provide a flexible OECT non-enzymatic glucose sensor and a preparation method thereof, and belongs to the technical field of glucose electrochemical sensors. According to the sensor, a chemically modified laser-induced graphene (LIG) electrode is used as a grid electrode, and gold nanoclusters (AuNC) are modified on LIG through controllable in-situ electrochemical reduction; meanwhile, the pH-dependent conductivity of PEDOT: PSS is utilized to realize the self-calibration of the sensor to the pH change of human sweat, so that the interference is reduced, and the measurement accuracy is improved. The flexible non-enzymatic glucose sensor designed by the invention has the advantages of high detection sensitivity, low detection limit, excellent long-term stability, no influence of pH value fluctuation and the like, and can be widely applied to the field of wearable electronics.

Embodiments relate to a non-enzymatic glucose sensor. The non-enzymatic glucose sensor comprises one or more electrodes, a microfluidic channel, and at least one inlet, wherein the at least one inlet is configured to deliver a fluid to a microfluidic channel and wherein the microfluidic channel is configured to transport the fluid to the one or more electrodes. At least one of the one or more electrodes is a laser-induced graphene electrode, wherein the laser-induced graphene electrode comprises one or more uniform coatings of metal.

The invention discloses a substrate integrated waveguide microwave sensor for glucose detection, and aims to solve the problem of low sensitivity of an existing non-invasive glucose sensor. The substrate integrated waveguide microwave sensor for glucose detection comprises an input feeder line, an integrated waveguide and a split ring resonator, the integrated waveguide is a fan-shaped microstrip line, the split ring resonator is arranged in the middle of the fan-shaped microstrip line, the input feeder line is located on the central axis of the integrated waveguide, and the split ring resonator is located in the middle of the integrated waveguide. One end of the input feeder line is located on the outer side of the arc of the integrated waveguide, the other end of the input feeder line extends into the integrated waveguide, and a metalized through hole array is arranged in the circumferential direction of the arc of the integrated waveguide. The SIW structure and the SRR structure are combined to be used for glucose detection, efficient space utilization and excellent electromagnetic characteristics are achieved, the performance and sensitivity of the sensor are remarkably improved, and the sensor shows excellent sensitivity and linear response in the glucose concentration range of 0-1000 mg / dL.

The invention relates to the technical field of glucose sensors, in particular to a direct electron transfer type sensor electrode mediated by a carbon nanomaterial, a preparation method of the direct electron transfer type sensor electrode and a glucose biosensor with the sensor electrode. The sensor electrode comprises: a base electrode having an electrode working area; the nanometer conducting layer is arranged on the electrode working area, and the nanometer conducting layer comprises a carbon nanometer material; and the analyte detection layer is arranged on the nano conductive layer, and the analyte detection layer comprises glucose dehydrogenase.

The invention provides an enzyme protective agent for a continuous glucose sensor and the continuous glucose sensor, the enzyme protective agent comprises the following components: poloxamer and a zwitterionic polymer, and the mass percent concentration of the poloxamer is 0.1%-2%, and the mass percent concentration of the zwitterionic polymer is 0.5%-5%. By adopting the technical scheme provided by the invention, the poloxamer and the zwitterionic polymer are introduced, so that an enzyme layer coating process can be optimized, a coffee ring effect can be inhibited, and the consistency and monitoring accuracy of the sensor can be improved; and on the premise of keeping the signal transmission performance of the sensor unchanged, the activity and long-term stability of the biological enzyme preparation in the production, storage, transportation and use processes are remarkably improved.

The invention relates to a continuous blood glucose monitoring circuit, which takes a 32-bit ARM (Advanced RISC Machines) processor of an STM32F407 singlechip as a main controller and an ADS131A04 high-precision synchronous sampling ADC (Analog to Digital Converter) chip as a core, comprises a main control circuit, a signal acquisition circuit, a constant potential circuit, a constant current circuit and a power supply circuit, is connected with a blood glucose sensor by adopting an FPC (Flexible Printed Circuit) connector, and is used for continuously monitoring blood glucose under the condition of constant current stimulation and constant voltage. The output signal of the sensor is collected in real time, and after the main control processes the data, the collected data is stored in the MicroSD card and is displayed on the screen at the same time. Intelligent control over the continuous blood glucose monitoring system is achieved by means of the high running speed and rich interface resources of the STM32F407; the multi-channel design can monitor relevant ion concentration parameters while collecting blood glucose signals, and can accurately monitor the blood glucose and the relevant ion concentration of a human body and correct the blood glucose signals in cooperation with a blood glucose sensor.

An example medical device includes an optical sensor, processing circuitry, an antenna, and a power source. The optical sensor includes a light source; a reference optical beacon having a first fluorophore that emits a first fluorescence proportional to a first concentration of a substance proximate the beacon; a test optical beacon having a reagent substrate that reacts with an analyte to produce the substance and a second fluorophore that emits a second fluorescence proportional to a second concentration of the substance proximate the test beacon; and a photodetector to detect the first and second fluorescence. The processing circuitry determines a difference between the first and second fluorescence, which is indicative of the concentration of the analyte. The antenna and power source enable the medical device to operate completely within a biological system for continuous analyte monitoring.

A method may comprise (a) inserting an insulin delivery device subcutaneously into a body of a subject, which comprises an amperometric glucose sensor comprising an electrode layer comprising an indicating electrode and underlying a redox-catalytic layer comprising a redox mediator; (b) using said insulin delivery device to deliver an insulin formulation (e.g., comprising a phenol or cresol excipient) subcutaneously to said subject; and (c) using said amperometric glucose sensor to measure a subcutaneous glucose concentration, which comprises using said redox-catalytic layer to allow electron transfer from subcutaneous glucose to said indicating electrode sufficient to cause a response of said amperometric glucose sensor at an applied bias potential of no more than +250 millivolts, wherein (b) and (c) are performed at the same time for at least one hour, while maintaining a sensor sensitivity of at least 50% of an initial sensor sensitivity for up to one hour.

A mathematical model of type 1 diabetes (T1D) patient decision-making can be used to simulate, in silico, realistic glucose / insulin dynamics, for several days, in a variety of subjects who take therapeutic actions (e.g. insulin dosing) driven by either self-monitoring blood glucose (SMBG) or continuous glucose monitoring (CGM). The decision-making (DM) model can simulate real-life situations and everyday patient behaviors. Accurate submodels of SMBG and CGM measurement errors are incorporated in the comprehensive DM model. The DM model accounts for common errors the patients are used to doing in their diabetes management, such as miscalculations of meal carbohydrate content, early / delayed insulin administrations and missed insulin boluses. The DM model can be used to assess in silico if / when CGM can safely substitute SMBG in T1D management, to develop and test guidelines for CGM driven insulin dosing, to optimize and individualize off-line insulin therapies and to develop and test decision support systems.

Techniques disclosed herein relate to glucose level measurement and / or management. In some embodiments, the techniques involve obtaining in vivo characteristics of a glucose sensor predicted using fabrication process measurement data associated with the glucose sensor, the in vivo characteristics including an in vivo sensitivity, an in vivo intercept, or a combination thereof; receiving sensor measurement data measured by the glucose sensor, the sensor measurement data including sensor current (Isig), counter voltage (Vcntr), electrochemical impedance spectroscopy (EIS) data, an age of the glucose sensor, or a combination thereof; and estimating a sensor glucose (SG) value using an SG model, wherein input parameters of the SG model include the in vivo characteristics of the glucose sensor and the sensor measurement data, and the SG value is an output of the SG model.

The present invention provides a wearable real-time sweat detection device and a detection method thereof. Using PDMS as a flexible substrate material, a microfluidic sweat collection channel is designed, and a wedge-shaped structure and a layered capillary pump are added to accelerate the collection efficiency of sweat. At the same time, PANI is used as a substrate, and a Cu-MOF glucose sensor is constructed on it. The detection performance of the sensor is greatly improved, and it has good selectivity and long-term stability. At the same time, combined with sodium and potassium ion selective electrodes, instant detection of sodium, potassium and glucose in sweat can be achieved. Data transmission is carried out through Bluetooth, which can be used for real-time monitoring of physical health information of pilots during long-term missions.

Continuous glucose monitoring systems can externally calibrate sensor glucose measurements using external source information relevant to the user's physiological state and surrounding environment. Factory calibration information from external sources can be utilized, generated by comparing metrics obtained from data used to produce the sensor's glucose detection algorithm with similar data from each subsequent batch of sensors used in that algorithm. The output glucose value of the glucose sensor can also be estimated by analyzing and optimizing the input sensor signal to accurately correct for variations in sensitivity, break-in time, glucose current drop, and other variable sensor wear effects. The foregoing can be implemented using correction factors, fusion algorithms, EIS, and advanced ASICs, thereby achieving the goal of improving accuracy and reliability without requiring blood glucose calibration, and providing calibration-free or near-calibration-free sensors.

An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver / hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and / or via wireless communication.

The invention is applicable to the technical field of material preparation and electrochemical sensing, and discloses a graphdiyne oxide gold nanoparticle composite electrode, a preparation method and application of the graphdiyne oxide gold nanoparticle composite electrode in a non-enzymatic glucose electrochemical sensor. Preparing the prepared graphdiyne oxide into an aqueous dispersion, taking carbon cloth as a substrate electrode, soaking the carbon cloth in the graphdiyne oxide dispersion after ethanol soaking, drying and surface treatment, drying, then soaking the carbon cloth in the prepared gold nanoparticle solution, and heating and drying to obtain the graphdiyne oxide gold nanoparticle composite electrode; the graphdiyne oxide and the gold nanoparticles are uniformly distributed on the surface of the carbon cloth. Due to the fact that rich oxygen-containing groups on the graphdiyne oxide can cooperate with the gold nanoparticles to promote catalytic oxidation of glucose, the non-enzymatic glucose electrochemical sensor prepared based on the electrode material has high catalytic activity on glucose and shows high sensitivity, selectivity and stability.

The invention belongs to the technical field of CGM sensors, and particularly relates to a CGM electrode sensor and a preparation method thereof.The preparation method comprises the following steps that three sets of stainless steel microneedle arrays are prepared from a stainless steel substrate and serve as a counter electrode, a reference electrode and a working electrode respectively; mechanically polishing the stainless steel microneedle array, and performing composite pickling activation; after surface pretreatment, a sol-gel deposition aluminum oxide layer is adopted; preparing a gold plating solution, and plating gold on the stainless steel microneedle array deposited with the aluminum oxide layer by adopting two-stage pulse electroplating; the working electrode is prepared by PMMA coating, adhesion layer construction, glucose oxidase immobilization and limiting layer construction; the counter electrode, the reference electrode and the working electrode are respectively embedded into the substrate to form the microneedle array electrode sensor with a three-electrode system. Based on a nickel-free direct gold plating process, good uniformity, strong binding force and lower cost after gold plating can be realized, so that the stability of the continuous glucose sensor in use is improved.

A voltage measurement type glucose sensor comprises a microneedle array including a flat part and a plurality of microneedles located on one surface of the flat part; an enzyme layer located on a surface of the plurality of microneedles and including glucose oxidase; a supercapacitor located on the other side of the flat part; and a wireless communication module electrically connected to the supercapacitor, and a glucose measurement method using the same. The glucose sensor is self-driving without the need to apply separate external power, improving the lifespan of the device and enabling close monitoring of accurate glucose levels in real time,