118 results about "Glucose sensors" patented technology

The invention relates to a continuous blood glucose monitoring circuit, which takes a 32-bit ARM (Advanced RISC Machines) processor of an STM32F407 singlechip as a main controller and an ADS131A04 high-precision synchronous sampling ADC (Analog to Digital Converter) chip as a core, comprises a main control circuit, a signal acquisition circuit, a constant potential circuit, a constant current circuit and a power supply circuit, is connected with a blood glucose sensor by adopting an FPC (Flexible Printed Circuit) connector, and is used for continuously monitoring blood glucose under the condition of constant current stimulation and constant voltage. The output signal of the sensor is collected in real time, and after the main control processes the data, the collected data is stored in the MicroSD card and is displayed on the screen at the same time. Intelligent control over the continuous blood glucose monitoring system is achieved by means of the high running speed and rich interface resources of the STM32F407; the multi-channel design can monitor relevant ion concentration parameters while collecting blood glucose signals, and can accurately monitor the blood glucose and the relevant ion concentration of a human body and correct the blood glucose signals in cooperation with a blood glucose sensor.

Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and / or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells.

The invention provides an energy complementation guidance method for endurance sports and related electronic equipment, and the energy complementation guidance method comprises the steps: receiving measured glucose data of a first time period from a glucose sensor, the measured glucose data reflecting the glucose level of an endurance athlete wearing the glucose sensor; receiving measured ketone body data from the ketone body sensor for a first period of time, the measured ketone body data reflecting a ketone body level of the endurance athlete wearing the ketone body sensor; predicting an energy result based on the measured glucose data and the measured ketone body data, the energy result representing whether the endurance athlete is energy depleted after a second time period after the first time period; and transmitting energy complementation information based on the energy result. Therefore, the accuracy of identifying the energy complementation opportunity can be improved.

The application discloses a kind of nickel-cobalt bimetallic enzyme-free glucose sensor materials and preparation method thereof, sensor;The nickel-cobalt bimetallic enzyme-free glucose sensor material is the composite material that nickel-cobalt bimetallic organic framework material is modified by nano silver particle;Wherein, the mole ratio of nickel-cobalt bimetallic organic framework material and nano silver particle substance in the composite material is 0.1-1.0:1;The sensor material is the composite material that nano silver particle is modified to nickel-cobalt bimetallic organic framework material, it not only has the advantage that bimetallic organic framework material specific surface area is big, more under the modification of silver particle, make nickel-cobalt bimetallic organic framework material have more excellent conductivity, so as to be used as enzyme-free glucose sensor material, sensor has higher sensitivity and reaction speed, so as to be more conducive to the large-scale application of enzyme-free glucose sensor.

This invention pertains to the field of glucose detection and discloses a copper-based MOF nanofiber membrane, its preparation method, and its application. The copper-based MOF nanofiber membrane is prepared by a method comprising the following steps: (1) adding a polyvinyl alcohol solution to a copper acetate solution to form a spinning solution; (2) electrospinning the spinning solution to obtain a copper-based nanofiber membrane; (3) calcining the copper-based nanofiber membrane in an air atmosphere to obtain a copper oxide fiber membrane; (4) mixing the copper oxide fiber membrane with an organic ligand, adding a solvent, and performing a hydrothermal reaction to obtain a copper-based MOF nanofiber membrane. The copper-based MOF nanofiber membrane prepared by this invention, as an electrode material for an enzyme-free glucose sensor, can improve conductivity, sensitivity, and anti-interference performance. Furthermore, the preparation method is simple and can be mass-produced.

A device for measuring and monitoring diabetes, consisting of a system-on-chip for real-time processing of sensor data, several sensors connected to the system-on-chip, including a blood glucose sensor, a heart rate sensor and a blood pressure sensor, a machine learning model implemented on the system-on-chip for analyzing the sensor data and generating a diabetes risk score, and a memory buffer within the system-on-chip for storing sensor data for trend analysis and improved prediction accuracy.

The invention belongs to the technical field of advanced materials and glucose detection, and relates to a 2D-MOF and MXene composite material, a printing type enzyme-free glucose sensor as well as a preparation method and application of the printing type enzyme-free glucose sensor. The preparation method of the composite material comprises the following steps: carrying out amination modification treatment on the MXene material; the MXene material subjected to amination modification treatment, nickel salt, BPY, TCPP and PVP are added into a mixed solvent of ethyl alcohol and DMF to be evenly mixed, and then a solvothermal reaction is conducted. The composite material has high catalytic activity, excellent conductivity and good dispersity, can be firmly attached to a flexible substrate, is high in stability, and can realize rapid and repetitive detection of glucose. The material can be prepared into conductive ink with good rheological property, is suitable for a printing process, can be used for preparing a wearable enzyme-free glucose sensor with high sensitivity and interference resistance, and has large-scale low-cost production potential.

A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.

The present application relates to the technical field of biosensor, especially to a glucose sensor based on composite film and a preparation method thereof, after fixing layered MoS2 semiconductor material on a substrate, the present application continues to prepare ion gel film on the substrate, then modifies glucose oxidase on the surface of the ion gel film, after incubation and fixation, modifies a layer of Nafion film on the surface of the ion gel film, because glucose oxidase oxidizes and decomposes glucose to generate protons, with the selective proton passing effect of the Nafion film, the protons pass through the Nafion film to the porous network structure formed by the ion gel film and the layered MoS2 semiconductor material, and cooperate with the cations in the ion gel film to attract more carriers, and form a double-layer structure on the surface of MoS2, cooperate with the current multiplication effect, improve the transmission efficiency of the carriers, and improve the sensitivity of the sensor.

A method may comprise (a) inserting an insulin delivery device subcutaneously into a body of a subject, which comprises an amperometric glucose sensor comprising an electrode layer comprising an indicating electrode and underlying a redox-catalytic layer comprising a redox mediator; (b) using said insulin delivery device to deliver an insulin formulation (e.g., comprising a phenol or cresol excipient) subcutaneously to said subject; and (c) using said amperometric glucose sensor to measure a subcutaneous glucose concentration, which comprises using said redox-catalytic layer to allow electron transfer from subcutaneous glucose to said indicating electrode sufficient to cause a response of said amperometric glucose sensor at an applied bias potential of no more than +250 millivolts, wherein (b) and (c) are performed at the same time for at least one hour, while maintaining a sensor sensitivity of at least 50% of an initial sensor sensitivity for up to one hour.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

A method of determining an insulin bolus to be administered by an insulin delivering device is disclosed. According to the inventive method, glucose measurement data corresponding to glucose level measurement signals detected by a continuous glucose sensor are received. An insulin bolus to be administered by the insulin delivering device is determined based on a formula having expressions indicative of, for example, glucose level derived from the glucose measurement data, carbohydrate-to-insulin ratio (CIR) and an insulin sensitivity factor (ISF). The method can be carried out using a processor of a device such as insulin pen, an insulin pump, a remote control device configured to remotely control an insulin pump or an insulin pen, a continuous glucose meter, a controller of a continuous glucose meter, a blood glucose meter, and a portable electronic device such as a smart phone, smart watch or tablet.

The invention discloses a high-activity non-enzymatic glucose sensor catalyst and a preparation method thereof. The catalyst takes a carbon material as a carrier and CuO as a catalytic active component. The preparation method comprises the following specific preparation steps: uniformly loading the active component on the carbon substrate through a chemical reduction method, and then carrying out annealing treatment in a muffle furnace to obtain the catalyst. According to the preparation method of the non-enzymatic glucose sensor catalyst with the CuO active component loaded on the carbon material, the steps of chemical reduction and thermal annealing treatment are adopted, the operation is simple, and the preparation method is suitable for large-scale preparation. The obtained catalyst is uniform in active component distribution, shows excellent glucose electrocatalytic oxidation performance, and can be applied to a non-enzymatic glucose sensor for glucose detection.

The invention relates to a Na-doped nickel-based phosphate / graphene composite material, an enzyme-free glucose electrochemical sensor, a preparation method and application of the Na-doped nickel-based phosphate / graphene composite material and the enzyme-free glucose electrochemical sensor in glucose detection, and solves the technical problems that an existing enzyme-free glucose sensor prepared on the basis of Ni salt is low in detection sensitivity and slow in response speed. The preparation method comprises the following steps: firstly, sequentially adding nickel salt, sodium salt and phosphate into a graphene dispersion liquid to form a mixed solution, then carrying out hydrothermal reaction on the mixed solution, and then carrying out calcination post-treatment. The method can meet the requirements on rapid and accurate detection of glucose in the fields of clinical diabetes diagnosis, food detection and the like, and has a wide application prospect.

The utility model discloses a shirt capable of monitoring blood sugar, and belongs to the field of intelligent wearable equipment. The shirt comprises a shirt body, a blood glucose monitoring assembly is arranged on the shirt body, the blood glucose monitoring assembly comprises four blood glucose sensors, the four blood glucose sensors are arranged on the armpits and the back portion respectively, blood glucose signals can be accurately collected, and the blood glucose monitoring assembly is electrically connected with a microprocessor arranged on the lower hem of the back portion of the shirt and a storage battery arranged on the rear side of a collar through a flexible circuit. The flexible circuit is coated with a waterproof layer and a wear-resistant layer, the microprocessor and the storage battery are both subjected to sealing waterproof treatment, and the storage battery adopts a flexible thin film battery and is matched with a magnetic attraction contact charging mode. The waterproof flexible display screen is arranged on the cuff of the shirt, the monitoring result can be displayed in real time, the sealed waterproof NFC electronic tag is sewn at the chest portion of the inner side, and health data can be conveniently stored and read. The non-invasive, real-time and continuous blood glucose monitoring is achieved, the parts are reasonable in layout, wearing is comfortable, the protective design is durable, the functions of convenient display and data management are achieved, and powerful support is provided for health management.

The invention discloses a 3D nano microneedle electrode for improving glucose monitoring performance and a preparation method and application thereof, and relates to the technical field of biosensing. The 3D nanometer microneedle electrode for improving the glucose monitoring performance comprises a microneedle electrode base material and an electrode sensing material, the microneedle electrode base material is a stainless steel intradermal injection needle, the microneedle electrode base material is filled with a conductive filler, the conductive filler comprises carbon paste and silver paste, and the electrode sensing material comprises an inner layer structure and a surface layer structure. The inner-layer structure is a conductive nano-carrier, and the surface-layer structure is a compound enzyme layer. The invention also provides a preparation method of the 3D nano microneedle electrode for improving the glucose monitoring performance. The utilization rate and catalytic activity of Prussian blue are improved, electron transfer is accelerated, and the problems that a traditional glucose sensor is low in electron transfer efficiency, insufficient in stability and limited in detection range and accuracy are effectively solved.

The invention discloses a preparation method of a high-conductivity multivalent nanowire and application of the high-conductivity multivalent nanowire to a non-enzyme glucose sensor. The copper nanowire with a high length-diameter ratio is prepared, a certain amount of thiourea is directly added into an ethanol solution of the copper nanowire, and conversion from the copper nanowire to the high-conductivity multivalent nanowire can be achieved under the condition of a specific reaction temperature. In the conversion process, the surface of the nanowire is synchronously induced to form a coarse structure, non-single valence copper sulfide active sites are constructed, and the formed synergistic effect can remarkably increase the number of the active sites, reduce an electrocatalytic oxidation reaction energy barrier and strengthen the specific adsorption capacity of glucose molecules, so that the non-enzyme glucose sensor is manufactured. The sensor shows ultrahigh detection sensitivity, ultralow response speed and excellent anti-interference performance, the preparation process is extremely simple, the cost is low, and the sensor has remarkable technical advantages and wide application prospects in the field of quantitative detection of glucose.

An insertion device configured to implant a first medical device and a second medical device in a user. The first medical device may be a fluid delivery cannula configured to deliver a fluid (e.g., insulin) to the user. The second medical device may be an analyte sensor (e.g., a glucose sensor) configured to detect a physiological characteristic of the user (e.g., a glucose level). The insertion device may be configured to be worn by the user. The insertion device includes a first linkage assembly configured to extend and retract a first insertion needle to implant the first medical device and a second linkage assembly configured to extend and retract a second insertion needle to implant the second medical device. The insertion device includes a user input device configured to cause the insertion device to initiate the implantation when activated by the user.

Various examples are directed to a glucose sensor comprising a working electrode to support an oxidation reaction and a reference electrode to support a redox reaction. The reference electrode may comprise silver and silver chloride. The Glucose sensor may also comprise an anti-mineralization agent positioned at the reference electrode to reduce formation of calcium carbonate at the reference electrode.

An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver / hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and / or via wireless communication.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

The technologies discussed herein relate to a biometrics system comprising one or more processors, computer storage memory having computer-executable instructions, surgically implantable devices, and wearables (e.g., an apparel item configured for an upper torso, an apparel item configured for a lower torso, a sock, a headband, other types of wearables, or one or more combinations thereof) having one or more biometric sensors (e.g., a heart rate sensor, a sweat sensor, a glucose sensor, other types of biometric sensors, or one or more combinations thereof) and one or more sensation devices (e.g., a plurality of visible light sources, a haptic feedback device, other types of sensation devices, or one or more combinations thereof). The wearables may also include one or more environmental sensors. The wearables emulate, transmogrify, or enhance one or more human senses using the one or more sensation devices based on biometric data or environmental data received.

Techniques disclose herein relate to determining glucose reference sample times. The techniques may involve determining a first glucose reference sample measurement for a patient. The techniques may further involve determining timing information for obtaining a second glucose reference sample measurement based at least in part on readings from a continuous glucose sensor.

The invention discloses a glucose sensor with an integrated flow channel sandwich structure, which comprises a first dielectric substrate, a liquid loading layer, a second dielectric substrate, an interdigital structure microstrip line and a ground lug, and is characterized in that the first dielectric substrate, the liquid loading layer, the second dielectric substrate and the ground lug are arranged from top to bottom according to a layered structure; the interdigital structure microstrip line is fixedly arranged on the top surface of the first dielectric substrate; a through hole is formed in the liquid loading layer, a liquid inlet is formed in one side face of the liquid loading layer, a liquid outlet is formed in the other side face of the liquid loading layer, the liquid inlet is communicated with the through hole through a first channel in the liquid loading layer, and the liquid outlet is communicated with the through hole through a second channel in the liquid loading layer. The glucose sensor provided by the invention can realize rapid and accurate glucose detection, the minimum detection concentration can reach 2mM, and the error degree is less than 0.005 dB.

An example method for initializing a glucose sensor includes executing an initialization sequence for the glucose sensor, wherein the initialization sequence is based on one or more of parameters related to manufacturing the glucose sensor or environmental conditions of the glucose sensor that are present in vivo, and reporting glucose levels in a patient after the initialization sequence.

The application discloses a kind of diabetic sarcopenia patient rehabilitation training device, including fixed module, training module, blood glucose monitoring module and controller.Fixed module is detachably installed at the tail of sickbed;Training module includes two side-by-side guiding carriages and the footrest slider sliding along it, the angle of guiding carriage is adjustable and is equipped with electromagnetic resistance adjusting mechanism, and the distance between two training modules is adjustable;Blood glucose monitoring module includes the abdominal belt wound on the abdomen of patient and the blood glucose sensor arranged on it;Controller is connected with each adjusting mechanism and blood glucose sensor respectively, and automatically adjusts the size of resistance according to blood glucose reading.The present application realizes the bedside lower limb rehabilitation training of bedridden patient, ensures the training safety through blood glucose-resistance intelligent linkage, and can adapt to the needs of patients of different body types and different rehabilitation stages.

Certain aspects of the present disclosure provide a therapy management system configured to monitor at least glucose concentration levels of a patient during a first time period using one or more glucose sensors to obtain glucose data, and determine a diabetic state classification of the patient based on the glucose data. The diabetic state classification indicates a diabetic state of the patient and comprises one of: a healthy classification, a pre-diabetic classification, a mild type 2 diabetes (T2D) classification, a severe T2D classification, or a gestational diabetes classification. The therapy management system is further configured to provide personalized feedback to the patient based on the determined diabetic state classification, wherein the personalized feedback comprises a recommendation for at least one of an exercise session, a dietary change, a lifestyle modification, a medication adjustment, or a continuous glucose monitoring wear schedule.

Arrangement for providing a glucose sensor, comprising: comprising a sensor control device: an electronics enclosure, comprising: a shell with an outer circumference and a first opening, and a holder which can be engaged with the outer circumference of the casing to define an interior of the electronics housing, wherein the holder has a second opening which is aligned with the first opening; a collar that is positioned in the electronics housing and can be engaged with the casing near the first opening, the collar having a central opening that is axially aligned with the first opening of the casing and the second opening of the holder; a printed circuit board that is arranged inside the electronics housing and comprises a variety of electronic modules; a glucose sensor comprising a proximal section and a distal section, wherein the proximal section is electrically coupled to the circuit board inside the electronics housing, and wherein the distal section extends from a bottom of the electronics housing and is configured to extend under the skin of a user to measure a glucose level in a body fluid; an adhesive patch that is attached to the underside of the electronics housing and configured to attach the sensor control device to a user's skin; a needle hub with a needle, wherein the needle hub is configured to engage with the collar, and wherein the needle has a distal section extending from the underside of the electronics housing; a sensor cap comprising a first section, a second section and an inner chamber, wherein the first section is detachably connected to the underside of the electronics housing, and wherein the inner chamber accommodates the distal section of the glucose sensor and the distal section of the needle.