24 results about "Glucose sensors" patented technology

The present application relates to the technical field of biosensor, especially to a glucose sensor based on composite film and a preparation method thereof, after fixing layered MoS2 semiconductor material on a substrate, the present application continues to prepare ion gel film on the substrate, then modifies glucose oxidase on the surface of the ion gel film, after incubation and fixation, modifies a layer of Nafion film on the surface of the ion gel film, because glucose oxidase oxidizes and decomposes glucose to generate protons, with the selective proton passing effect of the Nafion film, the protons pass through the Nafion film to the porous network structure formed by the ion gel film and the layered MoS2 semiconductor material, and cooperate with the cations in the ion gel film to attract more carriers, and form a double-layer structure on the surface of MoS2, cooperate with the current multiplication effect, improve the transmission efficiency of the carriers, and improve the sensitivity of the sensor.

An insertion device configured to implant a first medical device and a second medical device in a user. The first medical device may be a fluid delivery cannula configured to deliver a fluid (e.g., insulin) to the user. The second medical device may be an analyte sensor (e.g., a glucose sensor) configured to detect a physiological characteristic of the user (e.g., a glucose level). The insertion device may be configured to be worn by the user. The insertion device includes a first linkage assembly configured to extend and retract a first insertion needle to implant the first medical device and a second linkage assembly configured to extend and retract a second insertion needle to implant the second medical device. The insertion device includes a user input device configured to cause the insertion device to initiate the implantation when activated by the user.

Techniques disclose herein relate to determining glucose reference sample times. The techniques may involve determining a first glucose reference sample measurement for a patient. The techniques may further involve determining timing information for obtaining a second glucose reference sample measurement based at least in part on readings from a continuous glucose sensor.

Certain aspects of the present disclosure provide a therapy management system configured to monitor at least glucose concentration levels of a patient during a first time period using one or more glucose sensors to obtain glucose data, and determine a diabetic state classification of the patient based on the glucose data. The diabetic state classification indicates a diabetic state of the patient and comprises one of: a healthy classification, a pre-diabetic classification, a mild type 2 diabetes (T2D) classification, a severe T2D classification, or a gestational diabetes classification. The therapy management system is further configured to provide personalized feedback to the patient based on the determined diabetic state classification, wherein the personalized feedback comprises a recommendation for at least one of an exercise session, a dietary change, a lifestyle modification, a medication adjustment, or a continuous glucose monitoring wear schedule.

1. The name of the design product: continuous blood glucose monitor. 2. The use of the design product: a medical device that continuously tracks blood glucose levels through a subcutaneously implanted microsensor. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The application discloses an implantable blood glucose sensor outer membrane swelling calibration method based on ion concentration monitoring, which comprises the following steps: establishing a target ion concentration-functional outer membrane swelling kinetics relationship model, determining each parameter in the model through in-vitro simulation test; acquiring an initial electrochemical signal in subcutaneous tissue fluid by using a blood glucose sensing unit; acquiring the concentration of a target ion by using an ion concentration sensing unit; correcting the outer membrane swelling rate based on the target ion concentration-functional outer membrane swelling kinetics relationship model; and compensating and calibrating the initial electrochemical signal to obtain an electrochemical signal and a blood glucose concentration value after swelling correction. The application also discloses a system for executing the above method. The method effectively overcomes the problem of insufficient measurement accuracy caused by outer membrane swelling in the initial implantation stage, significantly improves the accuracy and reliability of the sensor in the key start-up stage, provides more timely and reliable blood glucose dynamic information for users, and has important application value.

This invention provides an electrochemical glucose sensor for continuous blood glucose monitoring, belonging to the field of biochemical sensing technology. The sensor includes a substrate and a three-electrode system, wherein the three-electrode system includes a working electrode, a reference electrode, and an auxiliary electrode. The working electrode comprises a conductive substrate, and an electrocatalytic enzyme composite layer and an outer membrane layer sequentially modified on the surface of the conductive substrate, with the outer membrane layer covering the outside of the electrocatalytic enzyme composite layer. The electrocatalytic enzyme composite layer is composed of glucose oxidase, an electron mediator, and a cross-linking agent. The glucose oxidase and the electron mediator are cross-linked and fixed to the surface of the conductive substrate by the cross-linking agent. This invention solves the technical problems of traditional electrochemical glucose sensors, such as long detection time, limited linear response range, low sensitivity and high detection limit, poor stability due to short-term signal drift, weak resistance to interference from sugar impurities and endogenous electroactive small molecules, and poor linearity and large detection error when directly detecting blood samples.

The application relates to the technical field of biosensors, and discloses a glucose sensor with a three-dimensional microcavity and a manufacturing method thereof, wherein the sensor comprises a substrate provided with at least one microcavity penetrating through the substrate; a conductive layer covering at least one side surface of the substrate and an inner wall of the microcavity, wherein the conductive layer located on the inner wall of the microcavity forms a three-dimensional microcavity sensing area; and a sensing film arranged in the three-dimensional microcavity sensing area and used for reacting with glucose to generate an electrochemical signal; the three-dimensional microcavity sensing area simultaneously provides an electrical connection path of the conductive layers on both sides of the substrate and a loading space of the sensing film. The sensor provided by the application has a high specific surface area feature, can improve the accuracy and long-term stability of the sensor, and is suitable for continuous monitoring of glucose and other physiological markers. Moreover, the manufacturing steps are highly standardized, batch production is easy to realize, and the consistency and stability of product performance are good.

The application belongs to the field of glucose detection, and particularly relates to an enzyme-free glucose sensor based on a hydrophobic substrate and a preparation method and application thereof. The application can realize glucose detection in various pH solution environments, reduces the dependence on high OH ‑ concentration of a solution; and the oxygen reduction reaction can be carried out at a lower reduction potential, which provides convenience for low-energy consumption use of the sensor.

An implantable glucose sensor includes: a housing, two injecting electrodes for injecting current into the tissue, two sensing electrodes for measuring impedance in the tissue, a coil within the housing for powering the sensor via a power source, a circuit board within the housing, the circuit board being electrically connected to the two sensing electrodes and the two injecting electrodes and the coil, and a communication unit for communicating data. The communication unit is connected to the circuit board. The two sensing electrodes and the two injecting electrodes are arranged on an outer surface of a first part of the housing. The outer surface of first part is of a convex shape. The two sensing electrodes and the two injecting electrodes are embedded in the convex shape so that they are flush with the outer surface of the convex shape.

This invention relates to the field of non-enzymatic glucose sensor technology, and particularly to a Ni-doped non-enzymatic glucose sensor, its preparation method, and its application. The method includes the following steps: cleaning and naturally drying a titanium wire, followed by constant-voltage deposition in a fluorine-containing electrolyte to obtain a Ti / TiO2 bilayer structure; annealing in air, followed by heating in an argon atmosphere, introducing a mixed atmosphere of hydrogen and a carbon source, holding at this temperature, stopping the gas introduction, and cooling to room temperature in an argon atmosphere to obtain a C / TiO2 / Ti multilayer structure; and finally, constant-voltage deposition in a nickel-containing mixed electrolyte to obtain the non-enzymatic glucose sensor. Using the above steps, the non-enzymatic glucose sensor obtained exhibits excellent catalytic activity for glucose oxidation in 0.1M NaOH solution, showing good linearity in the concentration range of 0.01–5.78 mM, with a sensitivity reaching 2624 μA·mM. ‑1 ·cm ‑2 The detection limit is approximately 0.5 μM, and the current response time is less than 2 s.

Abstract A monitoring feature, such as, for example, a pen cap, for an insulin delivery device may include at least one circuit adapted to detect at least one of a capping or decapping of the pen cap from an insulin pen and a processor for using information to the at least one of a capping or decapping of the pen cap. A monitoring feature for an insulin delivery device includes at least one circuit adapted to detect use of the insulin delivery device. USER Sensor Sensor Data Data GLUCOSE SENSOR SYSTEM 101 v SECOND FIRST ACCESSORY ACCESSORY MOBILE 103 102 APPLICATION g 104 MANUEL MANUEL DELIVERY DELIVERY DEVICE DEVICE 107 106 108 WEB x SERVICES 105 FIG. 1A 20 24 22 75 63 23 O ct 2 02 4 2 0 2 4 2 2 7 5 6 3 2 3 O c t 2 0 2 4 U S E R S e n s o r S e n s o r W O 2 0 1 9 / 1 1 8 5 3 1 D a t a G L U C O S E D a t a S E N S O R S Y S T E M 1 0 1 S U B S T I T U T E S H E E T ( R U L E 2 6 ) F I R S T S E C O N D A C C E S S O R Y A C C E S S O R Y M O B I L E 1 0 2 1 0 3 A P P L I C A T I O N 1 / 3 9 1 0 4 M A N U E L M A N U E L D E L I V E R Y D E L I V E R Y D E V I C E D E V I C E 1 0 6 1 0 7 1 0 8 W E B S E R V I C E S 1 0 5 P C T / U S 2 0 1 8 / 0 6 5 0 6 7 F I G . 1 A

A system for managing a patient's glucose level includes a glucose sensor to generate and store data signals for measurements of the patient's glucose level made by the glucose sensor; an insulin pump; and sensor electronics operatively coupled to the glucose sensor, the sensor electronics comprising a memory storing one or more predetermined characteristics associated with the sensor electronics; and a computing device in electronic communication with the sensor electronics. The computing device comprises a processor configured to operate the sensor electronics to (i) receive the generated data signals, (ii) obtain the one or more predetermined sensor characteristics from the memory and (iii) execute a closed-loop algorithm to provide insulin delivery instructions to an insulin pump by at least using the data signals and predetermined characteristics.

This invention provides an automated assembly method and apparatus for blood glucose sensor probes, relating to the field of automated blood glucose sensor assembly. The method includes: acquiring the identification information of an electrode strip; based on the identification information, acquiring a single-needle-level quality judgment result corresponding to the electrode strip, the single-needle-level quality judgment result including the qualification or non-qualification of multiple probes on the electrode strip; according to the single-needle-level quality judgment result, controlling an actuator to perform a discriminative assembly operation based on the single-needle-level quality judgment result; wherein, for probes judged as unqualified, the actuator is controlled to skip them; for probes judged as qualified, the actuator is controlled to perform a removal operation and insert the removed qualified probes into the sensor housing; and bending the qualified probes inserted into the sensor housing. This invention provides an automated assembly scheme for blood glucose sensor probes that can integrate front-end quality data, possess single-needle-level intelligent decision-making capabilities, and achieve a closed-loop data flow throughout the entire process.

A device for delivery of an insulin or insulin analog formulation and measurement of subcutaneous glucose concentration may comprise a hollow tube, and an amperometric glucose sensor located proximal to a distal end of the hollow tube. The amperometric glucose sensor may comprise a redox mediator and an enzyme comprising glucose oxidase or glucose dehydrogenase. An applied bias potential may allow an electrode layer of the amperometric glucose sensor to undergo substantially no electropolymerization of an excipient of the insulin or insulin analog formulation during continuous operation of amperometric glucose sensor. A sensitivity of the amperometric glucose sensor to the subcutaneous glucose concentration may be maintained in presence of the insulin or insulin analog formulation.

This document provides systems and methods for providing sensitive and specific alarms indicating blood glucose status. In one embodiment, the method for transitioning between states related to a subject's blood glucose status includes: evaluating sensor data from a continuous glucose sensor and activating an alarm state based on sensor data that meets activation transition criteria associated with a hypoglycemic or hyperglycemic state; providing an output associated with the activated alarm state, indicating a hypoglycemic or hyperglycemic state; transitioning from an activated state to a confirmed state over a period of time in response to at least one of the user-confirmed alarm state or data indicating that the subject's glucose is trending towards normal; actively monitoring data related to the subject's hypoglycemic or hyperglycemic state over a period of time in the confirmed state; and transitioning from the confirmed state to at least one of an inactive state or an activated state in response to data that meets predetermined criteria related to the subject's hypoglycemic or hyperglycemic state.

This invention discloses a flexible, enzyme-free sweat glucose sensor based on a nickel-cobalt sulfide composite film and its preparation method, belonging to the field of flexible electronics and biosensing technology. The sensor uses a flexible insulating film as a substrate and integrates a screen-printed carbon electrode system. It adopts a short-time electrodeposition-intermediate treatment cycle process: after applying a 5V voltage to the carbon working electrode for 30 seconds, the electrode is removed, residual droplets in the non-working area are wiped off, and the electrode is air-dried at room temperature. This process is repeated 3 to 4 times, thereby growing a uniform, dense, and strongly adherent nickel-cobalt sulfide nanocatalytic film in situ on the electrode surface. This process effectively avoids the swelling of the flexible porous carbon electrode and the cracking of the catalytic film by controlling the single reaction time and the forced interruption treatment, realizing the stable integration of high-performance materials. The sensor has excellent flexibility, mechanical stability, and high sensitivity and high selectivity electrochemical response to glucose.

The application discloses a preparation method of a biocompatible film for a biosensor and a glucose sensor; wherein the preparation method is specifically a preparation of the biocompatible film through a main chain monomer polymerization reaction, a side chain modification reaction, a side chain coenzyme modification reaction and coating film forming in sequence; the biocompatible film prepared by the preparation method can be applied to the biosensor, can not only realize accurate regulation and control of chemical substance permeation, expand the linear range of the biosensor for chemical substance detection, but also can provide a cofactor for the biosensor, and further increase the stability and durability of the biosensor.

This patent designs and synthesizes a metal-organic framework material—Co-TBTT—based on the dithienyloctacarboxylic acid ligand, and uses it as a non-enzymatic glucose electrochemical sensing material for glucose detection. Its potential in glucose sensing was evaluated through electrochemical performance testing. Experimental results show that the Co-TBTT-modified electrode exhibits excellent electrochemical response to glucose under enzyme-free conditions, with a linear detection range of 13.5 μM to 3 mM and a detection limit as low as 0.20 μM, outperforming most currently reported enzyme-free glucose sensors. The Co-TBTT electrode in the presence of Na... + K + Even in mixed solutions containing coexisting ions and interfering substances such as uric acid (UA), ascorbic acid (AA), and dopamine (DA), it maintains good anti-interference ability and exhibits strong selectivity. These excellent properties can be attributed to the porous structure and abundant metal active sites of the Co-TBTT material, providing a novel functional material for the electrochemical sensor detection of glucose.

This invention relates to the field of glucose electrochemical sensor technology, specifically to a vertically structured OECT flexible glucose sensor and its fabrication method. The sensor employs a vertical structure design, arranging the drain, source, and channel vertically, which improves the sensor's integration and reduces its size. Simultaneously, PVA doping enhances the electrochemical and mechanical properties of the PEDOT:PSS material, improving the electrochemical performance of the channel layer. Due to the vertical structure, the PEDOT:PSS-PVA composite material can be used to form a nanoscale flexible channel layer via high-speed spin coating, effectively shortening the electron path between the drain and source, significantly accelerating the device's response speed, greatly improving the channel current modulation efficiency, effectively increasing the transconductance of the channel layer, and also enhancing its flexibility. This allows the sensor to maintain good transconductance retention even under high periodic stress, enabling its application in wearable devices and other scenarios.

1. Name of the product in this design: Blood glucose sensor. 2. Purpose of this design: To detect blood glucose and collect user blood glucose information. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other situations requiring explanation: In the usage state reference diagram, part A is made of transparent material.

This application relates to a vital signs monitor and a vital signs detection system. The vital signs monitor includes: an implantable component configured to be implanted into the subcutaneous region of a human body; the implantable component includes: a circuit board on which a blood glucose sensor is disposed; the blood glucose sensor includes at least one first light-emitting element, a photosensitive element, and at least one first light-receiving element, wherein the first light-emitting element is used to emit a light signal of a first wavelength; the photosensitive element is used to contact glucose molecules in human tissue fluid and form a fluorescent group, the fluorescent group being used to receive the light signal of the first wavelength and excite a light signal of a second wavelength, the first wavelength being different from the second wavelength; the first light-receiving element is used to receive the light signal of the second wavelength, the second wavelength being used to determine the blood glucose information of the human body. The above-mentioned vital signs monitor enables long-term and accurate monitoring of vital signs information such as blood glucose.

The application provides an organic photoelectric transistor fluorescent dual-mode glucose sensor and a preparation method and application thereof, and the sensor is prepared by the following steps: dispersing inorganic nano powder in a conductive polymer solution to obtain a first mixed solution; immersing a first flexible fiber base material in the first mixed solution to obtain a first conductive fiber; mixing an inorganic quantum dot solution, a rare earth metal salt and an organic ligand to obtain a second mixed solution; placing a second flexible fiber base material in the second mixed solution and performing a hydrothermal reaction to obtain a second conductive fiber; coating conductive silver paste on two ends of the first conductive fiber to serve as a source electrode and a drain electrode; taking the second conductive fiber as a gate electrode; assembling the source electrode, the drain electrode and the gate electrode with a gel electrolyte to obtain an organic photoelectric transistor; and modifying glucose oxidase on a surface of the gate electrode of the organic photoelectric transistor to obtain the organic photoelectric transistor fluorescent dual-mode glucose sensor. The application has fast fluorescence and electrochemical response to glucose, high sensitivity and a good application prospect.

The present disclosure describes a preparation method of a working electrode of a glucose sensor suitable for mass production, the preparation method comprising the steps of: preparing a substrate layer having insulation; forming a conductive layer on the substrate layer, the conductive layer entirely covering the substrate layer as a whole, forming a plurality of limiting grooves with uniform size and shape on the conductive layer; and respectively dropping a predetermined amount of glucose sensitive reagent into the plurality of limiting grooves in a manner such that the glucose sensitive reagent is retained within the plurality of limiting grooves, and curing the glucose sensitive reagent to form a plurality of sensing parts. According to the present disclosure, the area and the uniformity of the morphology of the droplets of the glucose sensor can be controlled simply and conveniently, and the preparation method of the working electrode of the glucose sensor.