726 results about "Glucose detection" patented technology

Systems and methods for continuous measurement of a medicament in vivo are provided. In some embodiments, the system is configured to provide information associated with medicament titration and includes a continuous analyte sensor and a communication device. In some embodiments, the system is configured for continuous ambulatory drug testing, including an ambulatory host monitor having a continuous sensor, a location module, a processor module and a transmitter. In some embodiments, the system is configured for continuously monitoring a hormone level and includes a continuous hormone sensor and a communication device configured to output hormone information in real time. Yet another embodiment provides an analyte sensor for continuous monitoring of a host's nutritional status, and is configured for both continuous glucose detection and continuous albumin detection.

A sensor system including a holder with at least one semi-permeable layer that forms a chamber, at least one reactant that reacts with at least one analyte, the at least one reactant being contained within the chamber, and a detector disposed proximate the at least one semi-permeable layer and configured to detect and measure a concentration of a reaction product from reaction of the at least one reactant with the at least one analyte. The at least one semi-permeable layer allows passage of the analyte into the chamber and allows passage of the reaction product to the detector. In a preferred embodiment, the analyte includes glucose, and the reaction product detected includes carbon dioxide.

The apparatus for the non-invasive glucose detection comprises an electrical detection device (2) for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (4, 5), which allows to detect the pressure of the apparatus against the skin and / or quick movements. Further sensor modules, such as a temperature sensor (6) or alternative perfusion sensor (7), improve the accuracy of the measured result.

The invention discloses a physiological index detector. The physiological index detector comprises a microprocessor, a fingerprint identification sensor, a heart rate acquisition sensor, an arterial pressure sensor, a venous pressure sensor, a noninvasive blood glucose detection device, a temperature sensor, a wireless communication module, a GPRS short message communication device, a display screen and a warning device. The physiological index detector is a wristband-type structure fit to the wrist curve of the human body, components in the circuit portion are installed by using a flexible printed circuit (FPC), the FPC is mounted in the wristband-type physiological index detector in a circular arc shape, the display screen is an organic light emitting diode (OLED) which is arranged along the outer side of the wristband-type physiological index detector in an arc-shaped curve shape, and the wireless communication module transmits the acquired physiological index data of the human body to a cloud server for editing, preserving and processing. The physiological index detector is convenient to carry and measure and data are uploaded to the cloud, so that the physiological index data can be preserved for a long time, analyzed, tracked and warned.

The present invention relates to a preparation method for a copper oxide-graphene nano-complex modification glassy carbon electrode, and an application of the electrode as a glucose electrochemical sensor in rapid glucose detection, and belongs to the technical field of electrochemical analysis detection. According to the present invention, an electrochemical catalytic oxidation effect is adopted, and a current-time curve method is adopted to carry out sensitive quantitative analysis determination on the glucose, wherein the electrochemical catalytic oxidation effect is provided by the glucose sensor, and the copper oxide-graphene nano-composite material is adopted to modify the glassy carbon electrode to prepare the glucose sensor. The key point of the invention is: coating a naphthol suspension of the graphene on the surface of the treated glassy carbon electrode in a dropwise manner; carrying out open-air drying to form a layer of uniform modification layer; and adopting an electrodeposition method with a characteristic of simple operation to prepare a sensitive layer of the copper oxide-graphene nano-complex to achieve the stable catalysis of the glucose oxidation. The prepared glucose sensor of the present invention can be used clinically in detection analysis of blood glucose content in serum, and the determination process has characteristics of rapidness, sensitivity, accuracy, stability, low interference and the like.

An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto-conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized.

Networks of single-walled carbon nanotubes (SWCNTs) decorated with Au-coated Pd (Au / Pd) nanocubes are employed as electrochemical biosensors that exhibit excellent sensitivity (2.6 mA mM−1 cm−2) and a low estimated detection limit (2.3 nM) at a signal-to-noise ratio of 3 (S / N=3) in the amperometric sensing of hydrogen peroxide. Biofunctionalization of the Au / Pd nanocube-SWCNT biosensor is demonstrated with the selective immobilization of fluorescently labeled streptavidin on the nanocube surfaces via thiol linking. Similarly, glucose oxidase (GOx) is linked to the surface of the nanocubes for amperometric glucose sensing. The exhibited glucose detection limit of 1.3_M (S / N=3) and linear range spanning from 10 μM to 50 mM substantially surpass other CNT-based biosensors. These results, combined with the structure's compatibility with a wide range of biofunctionalization procedures, would make the nanocube-SWCNT biosensor exceptionally useful for glucose detection in diabetic patients and well suited for a wide range of amperometric detection schemes for biomarkers.

Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and / or non-functionalized nanowires are provided. Nanosensors are, used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.

The invention relates to a molecular imprinting photonic crystal for detecting glucose, which belongs to the technical field of applied chemistry and clinical analysis test. A method comprises the following steps: firstly, inserting a substrate subjected to hydrophilic treatment into PMMA colloidal pellet solution, and self-assembling pellets on the substrate to obtain a three-dimensional photonic crystal template; secondly, dripping molecular imprinting pre-polymerization solution on the edge of the three-dimensional photonic crystal template, and thermally polymerizing the template; and finally, cleaning the glucose imprinting template to obtain a glucose molecular imprinting photonic crystal template. The molecular imprinting photonic crystal has specific glucose adsorption performance, enables direct observation of the change, and fulfills the aim of real-time, quick and convenient detection.

The invention discloses a glucose detection sensor, and preparation and application methods thereof. The sensor comprises a three-electrode system, wherein a graphene / chitosan / glucose oxidase deposition modified glassy carbon electrode is used as a working electrode, a platinum sheet is used as a counter electrode, and a calomel electrode is used as a reference electrode. In the detection process, by using the graphene / chitosan / glucose oxidase deposition modified glassy carbon electrode as the working electrode, the platinum sheet as the counter electrode and the calomel electrode as the reference electrode, an electrochemical work station is utilized to determine the glucose content. Compared with the traditional method, the invention has the advantages of higher sensitivity and higher specificity, and the low detection limit is 4.0*10<-7> mol / L; and meanwhile, the glucose sensor has the advantages of simple preparation process, stable performance and short sample detection time, can be recycled, and is convenient to operate.

A body fluid sampling system for use on a tissue site includes a drive force generator and one or more microneedles operatively coupled to the drive force generator. Each of a microneedle has a height of 500 to 2000 μm and a variable tapering angle of 60 to 90°. A sample chamber is coupled to the one or more microneedles. A body fluid is created when the one or more microneedles pierces a tissue site flows to the sample chamber for glucose detection and analysis.

The invention discloses a TV (television) system based physiological index monitoring system and method. The system comprises a smart TV, a remote control unit, a cloud server, a proximity sensor, a fingerprint identification sensor, a heart rate sensor, a force sensor, a non-invasive blood glucose detection device, a temperature sensor, a GPRS (general packet radio service) short message communication device, a voice of internet phone, a heart rate abnormity warning device, a blood glucose abnormity warning device, a body temperature abnormity warning device and a grip strength abnormity warning device, wherein APP software is embedded in a smart TV chip. The system has the beneficial effects that the remote control unit and the APP software are connected with the cloud server to send the data acquired in real time to the cloud server to be stored, thus solving the problem that various physiological indexes can not be tracked for a long time; and the remote control unit serves as a carrier of a measuring instrument, so that the measuring instrument has various detection items and even detects the harmful substances such as formaldehyde in home environments, thus solving the technical problem of singleness of the detection items.

The invention provides a portable multifunctional intelligent insulin pump which has high degree of intensification and is based on the modern electronic technology, and a control module thereof, and the intelligent insulin pump is composed of an intelligent insulin pump body, a blood glucose detection sensor which is directly connected therewith and an infusion actuator. The change of the blood glucose is tracked by dynamic monitoring of the blood glucose level of a user, thus infusing the insulin for the treatment of diabetes. The insulin pump body is connected with a mobile phone by a communication protocol, and the user can control the infusion amount by the mobile phone. The errors of the monitoring of the blood glucose are calculated according to the characteristics of the self blood glucose and the basic amount of the normal blood glucose of the user, thus establishing the control model of the infusion pump. When the blood glucose content exceeds the allowable range, the controller emits a command, a drive mechanism allows the insulin in a liquid storage tank to pass a pipeline, and the insulin is infused to the body of the user by utilizing the infusion actuator. The invention is the complete and integrated novel insulin treatment instrument which has the effects of waterproof, corrosion resistance, vibration resistance and low power consumption and can not affect the normal life and be worked basically and normally.

A non-invasive blood glucose detection method comprises the steps that a pulse wave signal is obtained, and blood glucose concentration information of a sample to be detected is borne by the pulse wave signal; the obtained pulse wave signal is detected through first detection to obtain an initial detection value of blood glucose concentration; the obtained pulse wave signal is detected through second detection to obtain a detection interval which the blood glucose concentration belongs to; whether the detection belongs to the detection interval or not is judged, and if yes, the initial detection value serves as the blood glucose concentration value borne by the pulse wave signal. Due to the fact that judgment is conducted on the interval which the initial detection value belongs to, interference to the blood glucose concentration caused by other components can be effectively reduced, and the precision and the accuracy of blood glucose concentration detection are improved. The invention further discloses a non-invasive blood glucose detection device and system.

The invention discloses a preparation method of magnetic microspheres with a visible glucose detection function. The preparation method comprises the following steps: by utilizing a photonic crystal microsphere as a template, preparing magnetic photonic crystal hydrogel microspheres with reverse opal structures through a template copy method of hydrogel. A detection method comprises the steps that: a glucose molecule identification unit is combined with the magnetic photonic crystal hydrogel microspheres, wherein the existence or number of the glucose molecules is expressed by the displacement or color of the reflection peak of the photonic crystal microsphere; a magnet is used for collecting the magnetic microspheres according to the property that the magnetic microspheres have magnetism to improve the naked eye observation accuracy of the color of the magnetic microspheres. The visible glucose detection method based on magnetic microspheres with visible glucose detection function has the advantages of high sensitivity, strong specificity, simple operation, low cost, accurate observation, and the like.

The invention discloses a colorimetric detection method for glucose. The colorimetric detection method for the glucose comprises the steps of pretreating a sample, adding a buffer solution to dilute the sample, mixing the sample with glucose oxidase, performing reaction to generate hydrogen peroxide, then adding a molybdenum disulfide solution, a developing agent and the buffer solution, and measuring the content of the glucose in the sample by a visual colorimetry method or through an ultraviolet-visible light spectrophotometer after mixing reaction is implemented. According to the colorimetric detection method, glucose oxidase is used for oxidizing the glucose to generate the hydrogen peroxide, and molybdenum disulfide serving as a catalyst is used for catalyzing the hydrogen peroxide to generate color development reaction with the developing agent; the glucose concentration is measured in a semi-quantified manner by the visual colorimetry method or is measured in a quantified manner through the ultraviolet-visible light spectrophotometer. According to the colorimetric detection method for the glucose, the problems of high operation requirement on glucose detection, complicated detection process, high detection cost, long detection time, high background interference and the like in the prior art are solved; the method disclosed by the invention is low in cost and easy to operate; the glucose content of the sample can be quickly detected in a visual manner.

The invention relates to a blood glucose detection method based on a glucose meter. The method comprises the following steps: 1) the glucose meter is provided, a control terminal comprises automatic insulin injection equipment, electrocardiogram detection equipment, blood glucose detection equipment and an AVR32 chip, wherein the electrocardiogram detection equipment and the blood glucose detection equipment are used for extracting electrocardiogram data and blood glucose data of a detected person respectively; the AVR32 chip is connected with the automatic insulin injection equipment, the electrocardiogram detection equipment and the blood glucose detection equipment respectively, determines whether to send electrocardiogram parameter alarm signals or not on the basis of the electrocardiogram data and determines a control strategy of the automatic insulin injection equipment on the basis of the blood glucose data; 2), the glucose meter is used. With adoption of the method, an automatic insulin injection mode is adopted to replace the original manual insulin injection mode while whether the electrocardiogram data of the detected person are abnormal or not can be detected automatically, and the medical effect on the detected person is improved.

A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

The cathodized gold nanoparticle graphite pencil electrode is a sensitive enzymeless electrochemical glucose sensor based on the cathodization of AuNP-GPE. Cyclic voltammetry shows that advantageously, the cathodized AuNP-GPE is able to oxidize glucose partially at low potential (around −0.27 V). Fructose and sucrose cannot be oxidized at <0.1 V, thus the glucose oxidation peak at around −0.27 V is suitable enough for selective detection of glucose in the presence of fructose and sucrose. However, the glucose oxidation peak current at around −0.27 V is much lower which should be enhanced to obtain low detection limit. The AuNP-GPE cathodization increases the oxidation peak current of glucose at around −0.27 V. The dynamic range of the sensor is in the range between 0.05 to 5.0 mM of glucose with good linearity (R2=0.999). Almost no interference effect was observed for sensing of glucose in the presence of fructose, sucrose and NaCl.

The invention provides a glucose detection method. The glucose detection method comprises the following steps: (1) preparing: preparing an in-vitro biological synthetic system; (2) adding: adding a sample into the synthetic system in step (1); (3) synthesizing: starting the in-vitro biological synthetic reaction of a target object; (4) detecting: detecting a signal intensity of the synthesized target object in the synthetic system; and (5) calculating: calculating a glucose concentration or content of a to-be-detected sample according to a signal intensity-glucose concentration relation curve.The invention also provides a glucose detection kit adopting the detection method stated in a first aspect and an application of the glucose detection kit in detecting blood glucose and urine glucose. Compared with a glucose oxidase electrode method in the prior art, the glucose detection method has the advantages of high specificity, high sensitivity, less external interference, ease in high-flux and big data measurement and the like.

The invention discloses a preparation method and an application of a layered nickel-cobalt hydroxide. ZIF-67 and Ni salt are mixed into an organic solvent at certain proportion and concentration, are heated and refluxed under the condition of magnetic stirring, and are centrifuged and separated, washed, and dried in vacuum to obtain a final product. The preparation method is simple and quick, the material is used to detect glucose, the detection sensitivity is very high, the detection scope is relatively wide, and the material has a great application prospect in the field of blood sugar monitoring.

The invention discloses a non-invasive blood glucose detection sensor integrator which is improved from a non-invasive blood glucose detection sensor probe and is a second-generation non-invasive blood glucose detection sensor probe. The detection voltage of the probe is 5v. The probe comprises a pedestal (1), a finger surface blood flow velocity detection zone(2), a human body local(finger) metabolic rate detection zone(3), a finger tip blood oxygen infrared detection zone(4), a circuit connection zone(5), and a signal input and output zone(6). The sensor probe is capable of non-invasively, quickly and accurately detecting the relevant parameters for calculating blood glucose time after time, and is simple to use, suitable for families, simple in fabrication technique and method and suitable for mass production.

The invention provides a multi-parameter intelligent physiological detection glove which comprises a glove body, an electromechanical box, a blood glucose detection sensor, a blood oxygen detection sensor and a blood pressure detector. The blood glucose detection sensor acquires blood glucose data, the blood oxygen detection sensor acquires blood oxygen data, the blood pressure detector acquires blood pressure data, the electromechanical box processes and then displays the acquired blood glucose data, the acquired blood oxygen data and the acquired blood pressure data and is positioned at the back of the glove body, the blood glucose detection sensor and the blood oxygen detection sensor are positioned at finger tips inside the glove body respectively, and an inflatable wrist strap of the blood pressure detector is positioned on a wrist portion of the glove body. By the aid of the multi-parameter intelligent physiological detection glove, a user can timely and accurately know various physiological parameters, preparation is made in advance, and human body discomfort and even life threat caused by cardiovascular problems are effectively prevented.

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood in a sample. Disclosed techniques include (1) using a standard deviation operation in conjunction with the logarithm function, (2) using a normalization factor, (3) using a ratio factor, (4) accounting for the effect of temperature on various system components such as resistors, and (5) accounting for dark current in a light detector by performing a calibration.

The invention provides test paper and a detection method for glucose determination. According to the test paper, glucose oxidase and peroxidase are embedded in a cavity of a polymer, namely hollow nanofibers, in an in-situ manner by using a coaxial co-spinning electrospinning technique, and a color developing agent, namely o-dianisidine, is uniformly distributed on shell layer walls of the hollow nanofibers, and thus the glucose detection test paper with a macroscopic non-woven membrane morphology is obtained. When glucose liquid is dripped on the test paper, glucose is oxidized by the glucose oxidase, hydrogen peroxide is produced, and the colorless o-dianisidine is oxidized to a colored product under the catalysis of the peroxidase, so that the test paper can be subjected to color development, and the quantitative detection on the glucose is carried out through determining the color change of the test paper. A glucose detection reagent based on the hollow nanofibers has the outstanding advantages of simplicity in preparation, small enzyme consumption amount, simplicity and convenient in detection operation, and high storage stability and has an application prospect in the quick and accurate determination of the glucose.

The invention discloses an Au NPs-CeO2@PANI nanocomposite, a preparation method thereof and a glucose biological sensor manufactured by utilizing the nanocomposite. Firstly, the Au NPs-CeO2@PANI nanocomposite is composited by utilizing cerium dioxide (CeO2) nano particles, aniline (An) monomers and aurum (Au) nano particles; and the Au NPs-CeO2@PANI nanocomposite is fixed with glucose oxidase, soas to manufacture the glucose biological sensor. The nanocomposite prepared in the invention has a good compatibility and is favourable for fixing bioenzyme; the cost of the preparation method is low, and the preparation method is simple and fast. The biological sensor manufactured in the invention has the advantages of high sensitivity, good stability and wide linear range, and has a certain capacity for resisting interference, therefore the biological sensor can be widely used in the fields of diabetes diagnosis and food process monitoring. The linear range for detecting diabetes is 6.2*10<-6> to 2.8*10<-3>M, and the detection limit is 1.0*10<-6>M.

The invention discloses a preparation method of a rare-earth coordination polymer fluorescence probe and an application of the rare-earth coordination polymer fluorescence probe in H2O2 and glucose detection and belongs to the technical field of optical sensing. The preparation method comprises steps as follows: triphosadenine is mixed with a Tris-HCl buffer solution containing Ce<3+>, and the rare-earth coordination polymer fluorescence probe ATP-Ce-Tris is prepared; when H2O2 is present in the solution, Ce<3+> in the ATP-Ce-Tris is oxidized into Ce<4+> by H2O2 to result in fluorescence quenching of the ATP-Ce-Tris, and accordingly, detection of H2O2 is realized; simple and sensitive detection of glucose is further realized through fluorescence quenching of the ATP-Ce-Tris due to H2O2 which is produced through catalytic oxidation of glucose by glucose oxidases.

The invention relates to a preparation method of a glucose sensor, and in particular to a preparation method of a non-enzyme electrochemical glucose sensor, aiming at solving the problem that the existing glucose sensor cannot carry out non-enzyme electrochemical glucose detection under the neutral and partial neutral conditions. The method comprises the steps of 1, grinding and cleaning an electrode; 2, detecting the performance of the electrode; 3, synthesizing: dissolving Co(NO3)2 6H2O in methyl alcohol, and stirring for dissolving to obtain a solution A; dissolving dimethyl imidazole in the methyl alcohol, and stirring for dissolving to obtain a solution B; then, mixing the solution A with the solution B, and standing; 4. cleaning and drying to obtain a metal-organic framework material ZIF-67; 5, carrying out heat treatment; 6, adding black powder into a solvent to obtain suspension liquid, carrying out ultrasonic treatment on the suspension liquid, adding the treated suspension liquid onto the surface of the glassy carbon electrode drop by drop, and drying to obtain the non-enzyme electrochemical glucose sensor. The non-enzyme electrochemical glucose sensor can carry out non-enzyme electrochemical glucose detection under the neutral and partial neutral conditions, and is simple and practicable as well as low in cost. The non-enzyme electrochemical glucose sensor is used for detecting glucose.

The invention discloses a two-dimensional nickel and cobalt MOFs (metal organic frameworks) nano-sheet and an application of the nano-sheet to glucose detection. The two-dimensional nickel and cobalt MOFs nano-sheet is synthesized on substrates such as nano-porous gold needles, carbon paper and gold sheets by a one-step hydrothermal method from bottom to top, serves as an electrode and is applied to a non-enzyme electrochemical glucose sensor. A two-dimensional nickel and cobalt MOFs nano-sheet material has the advantages that more active sites are exposed, nickel and cobalt are cooperated, charge transfer capacity is high and the like relative to a traditional spherical polyhedral MOFs material, so that glucose sensing properties of the nano-sheet material is effectively improved.