336 results about "Glucose detection" patented technology

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.

The invention discloses a method for evaluating postprandial blood glucose response of a human body based on continuous blood glucose data and application. The method comprises the following steps: acquiring a continuous blood glucose detection value and meal starting time; matching a first blood glucose recording point after eating according to the dining time, intercepting blood glucose data of 2 hours after meal, and preprocessing the data; constructing four postprandial blood glucose response modes by applying the continuous blood glucose data of FPCA and based on a characteristic function of which the interpretation degree ranks top two obtained by the FPCA; through comparison of postprandial blood glucose response mean value curves of the four blood glucose response modes, the four response modes can evaluate postprandial blood glucose by integrating the blood glucose concentration range and whether the fasting homeostasis can be rapidly recovered or not.

The invention belongs to the technical field of medical health monitoring, and relates to a noninvasive blood glucose detection method based on reinforcement learning and multi-modal dynamic weight fusion, and the method comprises the following steps: carrying out adaptive dynamic weight distribution on the weight of an ECG signal and a PPG signal based on a reinforcement learning network, optimizing a signal processing parameter, and determining whether to trigger threshold adjustment; performing weighted feature fusion on the ECG signal and the PPG signal to obtain a fusion feature vector; the fusion feature vector is input into a prediction and early warning double-branch output structure, the prediction and early warning double-branch output structure comprises a regression branch and a classification branch, the regression branch is used for continuously predicting the blood glucose value, and finally a single blood glucose concentration value is output; and the classification branch is used for early warning level judgment, and finally outputting classification alarms for continuous prediction results so as to complete noninvasive blood glucose detection. The method has the beneficial effects that the fluctuation influence of user movement and temperature on noninvasive blood glucose data acquisition is reduced, and the individual difference suitability and long-term stability of noninvasive blood glucose detection are improved.

The invention relates to the field of nano-enzymes, in particular to a nano-enzyme, a preparation method and a method for detecting glucose by using the nano-enzyme. The nano-enzyme comprises a carrier and platinum nano-particles coated on the surface of the carrier, and the carrier is oxidized nano-diamond particles with the particle size of 20-30 nm. The core structure of the nano-enzyme, namely a composite system of the carrier and the platinum nano-particles, is defined, the platinum nano-particles serve as a metal nano-material with excellent catalytic performance and are a core component for simulating peroxidase activity, the size of the oxidized nano-diamond carrier is controlled to be 20-30 nm, the dispersity of the material is guaranteed, and the catalytic activity of peroxidase is improved. And the catalytic efficiency of the composite system can be further improved through a size effect. According to the structural design, the problems of insufficient catalytic activity and poor stability of a single nano material are solved through the synergistic effect of the carrier and the load component, and a material foundation is laid for subsequent efficient glucose detection.

The invention discloses a real-time adjusting method for insulin infusion volume, which adopts a closed-loop control method, and dynamically adjusts the infusion volume of an insulin pump based on a comparison result of a predicted blood glucose parameter and a preset blood glucose range through collected blood glucose data and predicted future blood glucose data, thereby realizing more accurate blood glucose control. The invention further discloses a closed-loop infusion system designed based on the real-time adjustment method. The closed-loop infusion system comprises a controller, a blood glucose detection system, an insulin pump and a continuous glucose monitoring system. Compared with open-loop control, the closed-loop control can monitor the blood glucose level of the patient in real time and automatically adjust the insulin infusion amount according to real-time data, and the high-automation system can more accurately maintain the blood glucose within the target range and reduce blood glucose fluctuation. Moreover, the closed-loop control system reduces the requirements of patients or medical staff for manually calculating and adjusting the insulin dosage, so that personal errors are reduced, automatic adjustment can better adapt to individual differences and dynamic changes of the patients, the burden of the patients on blood glucose monitoring and insulin dosage adjustment is reduced, and the safety and effectiveness of treatment are improved.

The invention provides a power management and power consumption control device and method of a continuous blood glucose detection circuit. Relates to the technical field of continuous blood glucose detection, solves the problems of power consumption control and switching in the prior art, and is characterized in that a power input end of a charge pump is connected with an anode of an external power supply; the control input end of the charge pump is connected with a mode control signal end; the power output end of the charge pump is connected with the first control end of the power switch device; the switching signal control end of the charge pump is connected with the second control end of the power switching device through the delayer; the output end of the power switch device is connected with the working voltage input end, and the working voltage output end is connected with the grounding capacitor; the power output end of the charge pump is connected with the input end of the power-on reset module, the power switch switching signal end of the power-on reset module is connected with the power switch switching signal end of the charge pump, and different working modes can be achieved, so that power consumption control is achieved.

The invention provides a Ru / RuO2 nano foam enzyme as well as a preparation method and application thereof, and belongs to the technical field of nano enzymes. The preparation method of the Ru / RuO2 nano foam enzyme comprises the following steps: uniformly mixing graphene, a ruthenium precursor and a solvent, carrying out reflux reaction, and collecting a solid product A; and mixing the solid product A and the molten salt 1, grinding, adding into the molten salt 2 in a molten state, preserving heat, and cooling, washing and drying after the heat preservation is finished to obtain the Ru / RuO2 nano foam enzyme. The preparation method disclosed by the invention does not need a tight inert atmosphere and a complex calcining process, and is simple; the colorimetric sensing method for glucose detection based on the nano-enzyme has extremely low detection limit, shows high specificity and sensitivity, and is suitable for accurate glucose detection.

The invention provides a full-dynamic non-invasive blood glucose detection method based on a full-spectrum peak segment optimization algorithm. The method comprises the following steps: step S1, performing blood glucose testing on a nail bed part of a human little finger by matching an infrared dual-wavelength semiconductor laser with a spectrograph, and recording blood glucose Raman spectrum data obtained in each blood glucose testing; step S2, carrying out pretreatment on the obtained blood glucose Raman spectrum data; s3, dividing the preprocessed blood glucose Raman spectrum data into a training set and a prediction set, analyzing through a principal component analysis method and a partial least square regression analysis method, and establishing a model; s4, inputting the preprocessed blood glucose Raman spectrum data as an independent variable into the model in the step S3, analyzing the blood glucose concentration of the human body, and giving a reference value; according to the full-dynamic non-invasive blood glucose detection method based on the full-spectrum peak segment optimization algorithm, the accuracy of quantitative analysis of a high-fluorescence background sample through a Raman spectrum is achieved, complex treatment on the sample is not needed, and the accuracy of human body non-invasive blood glucose detection is improved.

The invention discloses a hydrogel microneedle patch for noninvasive blood glucose detection as well as a preparation method and application of the hydrogel microneedle patch. According to the invention, the microneedle patch is prepared by a turnover technology and is noninvasively applied to the skin surface, so that simple and rapid extraction of interstitial fluid in vivo and a new method for real-time, rapid and quantitative detection of blood glucose in vivo are realized. The hydrogel microneedle patch contains two hydrogel components: one hydrogel component is hydrogel which can be cured and formed by ultraviolet light, and the other hydrogel component is hydrogel which can be cured and formed by ultraviolet light; and the other hydrogel is functional hydrogel with pH responsiveness, and glucose oxidase is added, so that the hydrogel can sensitively react to in-vivo glucose. The double-response hydrogel is jointly mixed and prepared into a microneedle patch form, the microneedle patch is endowed with noninvasive / minimally invasive property when applied to the skin surface, the microneedle patch is very suitable for extraction of interstitial fluid in vivo, and then real-time, rapid and accurate detection of the blood glucose level in vivo is achieved.

According to the intelligent real-time blood detection system based on the intravascular indwelling sensors, through an intravascular indwelling multi-sensor integrated system (electrochemical / optical coaxial layered design), continuous monitoring of one-time puncture for more than or equal to 7 days is achieved, in a clinical test, puncture within 7 days can be reduced from 28 times to 3 times, an improved Kalman filtering algorithm eliminates signal crosstalk, and the detection accuracy is improved. The D-S evidence theory is combined to dynamically fuse multi-modal data, so that the blood glucose detection MARD is reduced to 4.1%, the blood potassium error is less than 0.08 mM, and the motion artifact residual error is 1t; and 0.5%. A real-time data transmission and intelligent alarm system significantly improves clinical response efficiency, self-adaptively calibrates individual differences, and realizes high-precision long-acting monitoring.

The utility model provides blood glucose detection test paper and a blood glucose detection test paper storage box, and relates to the technical field of blood glucose detection consumables, the blood glucose detection test paper comprises a substrate, an electrode layer is laid on the substrate, and a mistake-proof slot is formed in the lower part of the substrate; an insulating layer is arranged above the electrode layer, a sampling window is formed in the insulating layer, an enzyme layer and a hydrophilic layer are arranged in the sampling window, the enzyme layer is attached to the upper surface of the electrode layer, and the hydrophilic layer is arranged above the electrode layer; a release film is laid on the insulating layer, the release film is divided into a sampling end, a main body and an electrode end through an easy-to-tear line, and the divided release film covers the sampling window, the insulating layer main body and the electrode end respectively. The sealing structure has the advantages of good sealing performance and capability of avoiding wrong insertion of front and back surfaces of electrode ends.

The invention discloses a preparation method and application of an iron-based covalent organic framework enzyme-loaded biological cascade catalytic material, and belongs to the field of materials. An iron-based covalent organic framework material is prepared by adopting a one-pot method, and glucose oxidase is further loaded, so that the biological cascade catalytic material for glucose detection is prepared. The biological cascade catalytic material obtained by the preparation method disclosed by the invention combines the advantages of nano enzyme and natural enzyme, and has excellent catalytic efficiency and long catalytic life; the Fe-COFs prepared by the method disclosed by the invention is strong in peroxidase-like activity and high in enzyme loading capacity, can adapt to a cascade system loaded by various enzymes, and widens the application prospect of constructing a biological cascade catalytic system based on COFs loaded natural enzymes.

The invention discloses a glucometer high-precision detection method based on a dynamic calibration algorithm and a glucometer, and relates to the field of blood glucose detection.The method comprises the steps that modal decomposition is conducted on a blood glucose current signal, the blood glucose current signal is decomposed into a plurality of frequency components, and an effective physiological component and an interference component are separated from the frequency components; performing time sequence feature extraction on the effective physiological component to obtain feature parameters at multiple moments, and performing correlation analysis on the feature parameters at the multiple moments, the environment temperature and the tissue impedance parameter to obtain a fusion feature vector; inputting the fusion feature vector into a parameter calibration model, and outputting a preliminary blood glucose value; a temperature correction coefficient is calculated according to the deviation between the environment temperature and the preset reference temperature, the initial blood glucose value is dynamically adjusted according to the temperature correction coefficient, and a final blood glucose detection value is obtained. By implementing the method, the detection accuracy of the glucometer can be improved.

The invention discloses a personalized adoptive non-invasive blood glucose monitoring method, system and device and a medium, and the method comprises the steps: obtaining a blood glucose sample and a physiological parameter sample of a target individual, and calibrating a trained universal artificial intelligence prediction model according to the blood glucose sample and the physiological parameter sample of the target individual, a personalized artificial intelligence prediction model is obtained; the universality artificial intelligence prediction model is obtained by training according to a blood glucose sample and a physiological parameter sample of a group; acquiring physiological parameters of the target individual, and monitoring blood glucose of the target individual according to the physiological parameters of the target individual and the personalized artificial intelligence prediction model; the physiological parameters are obtained through non-creative measurement. The embodiment of the invention can noninvasively, accurately and continuously monitor the blood glucose of the target individual, and can be widely applied to the technical field of blood glucose detection.

The invention relates to the technical field of glucose detection, in particular to a high-sensitivity glucose detection material and a preparation method thereof. The preparation raw materials of the high-sensitivity glucose detection material comprise the following components in parts by weight: 1-2 parts of modified glucose oxidase, 6-10 parts of modified porous microspheres, 1-1.5 parts of chloroplatinic acid and 0.6-1 part of palladium acetate. The prepared detection material is high in detection sensitivity and good in repeatability and stability.

The invention relates to the technical field of sensors, in particular to a CIOD-based noninvasive blood glucose detection sensor and method.The sensor comprises a multi-layer structure and comprises a first flexible polyimide substrate tightly attached to the skin, a temperature control assembly, a second flexible polyimide substrate and a glucose detection patch; the temperature control assembly comprises a temperature sensor and a heating wire and is used for thermally activating the skin; the glucose detection patch comprises three electrode areas filled with perfluorinated sulfonic acid resin, wherein the first electrode area comprises a first sodium ion working electrode, a shared electrode and a detection working electrode; the second electrode region contains a sodium ion reference electrode; the third electrode area comprises a second sodium ion working electrode and an auxiliary electrode; the electrodes are connected through insulating coating wires; the shared electrode and the auxiliary electrode form an interstitial fluid extraction electrode pair, and the detection working electrode and the shared electrode form a glucose detector to detect a hydrogen peroxide signal generated by glucose oxidation; the first sodium ion working electrode, the second sodium ion working electrode and the sodium ion reference electrode form a sodium ion differential detector to calibrate a glucose signal. According to the novel noninvasive blood glucose detection sensor provided by the invention, efficient, noninvasive and portable blood glucose monitoring can be realized by combining thermal activation and differential self-calibration.

A glucose detection or monitoring system that includes a VCSEL laser with one or more active regions having quantum wells and barrier. The active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure, and one or more tunnel junctions (TJ). One or more apertures are provided with the selected shape structure, one or more buried tunnel junctions (BTJ) or oxide confine apertured, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process with a VCSEL output determined in response to a monitoring application of the VCSEL, the VCSEL having an HCG grating and a bottom DBR. A housing of a smartwatch interior houses the VCSEL laser. The smartwatch includes one or more of a display, an optical sensor, one or more electrodes, SIM card slot, speaker, microphone, charging pins, and a band.

The invention discloses a rapid detection device for diabetic nephropathy patients, and belongs to the technical field of diabetic nephropathy patient detection.The rapid detection device comprises a blood glucose detection assembly, a self-adaptive adjusting mechanism, an extrusion force adjusting structure and an automatic blood taking mechanism, and the self-adaptive adjusting mechanism is arranged on the blood glucose detection assembly; the extrusion force adjusting structure is arranged in the blood glucose detection assembly, the extrusion force adjusting structure is connected with the self-adaptive adjusting mechanism, the extrusion force adjusting structure comprises an adjusting assembly and a reciprocating displacement assembly, and the automatic blood taking mechanism is arranged on the blood glucose detection assembly. By arranging the self-adaptive adjusting mechanism, the extrusion force adjusting structure and the automatic blood taking structure, the extrusion force for assisting the blood taking structure of the person to be detected is self-adaptively adjusted according to different thicknesses of the hands of the person to be detected, and it is ensured that the device can take out sufficient blood for detection; and tissue fluid groups which influence a detection result can be prevented from existing in blood, so that the detection precision of the device is improved.

The invention discloses an electrochemical sensor and a wearable glucometer, and relates to the technical field of sensors, the electrochemical sensor comprises a working electrode, a counter electrode and a substrate, the working electrode and the counter electrode are both arranged on the substrate, and the projection area of the working electrode on the substrate is smaller than the projection area of the counter electrode on the substrate. The invention aims to improve the current signal stability of the electrochemical sensor so as to realize the sensitivity and reliability of detecting glucose in the body fluid of a diabetic patient.

The invention belongs to the field of blood glucose test strip storage boxes, and provides a sealed pressing type blood glucose test strip cross contamination prevention storage box which comprises a sealing box, a paper outlet groove is formed in the upper side of the sealing box, a paper storage box is slidably arranged in the sealing box, a test strip body is arranged on the inner bottom wall of the paper storage box, and a fixing box is fixedly installed on the side wall of the sealing box. A top plate is rotationally arranged in the sealing box, one end of the top plate is in contact with the lower surface of the paper storage box, the other end of the top plate extends into the fixing box, a button is fixedly mounted on the upper surface of the top plate, and a channel is formed in the side wall, connected with the storage box, of the fixing box; non-contact taking of blood glucose test paper is achieved through the pressing type paper outlet mechanism, and cross contamination caused by the fact that fingers make direct contact with a test paper detection area is effectively avoided; by adopting inclined block guiding, extrusion wheel limiting and elastic resetting structures, the test paper is ensured to be uniformly stressed and stably sent out in the taking process, the test paper is prevented from being damaged due to friction or extrusion, and the accuracy and reliability of blood glucose detection are remarkably improved.

The invention discloses a chiral precious metal nanocage induced and synthesized by penicillamine and a preparation method and application thereof, precious metals in the chiral precious metal nanocage are palladium, platinum and gold, the molar ratio of palladium to platinum to gold is (16-18): (24-28): (56-59), and the chiral precious metal nanocage has three-dimensional chiral morphology characteristics induced by penicillamine chiral molecules. And the edge length is in a nanometer size. Chiral deposition growth of gold atoms in two palladium-platinum nanometer hollow frame structures (cubes and icosahedrons) is induced through chiral penicillamine molecules (D- / L-penicillamine), and a chiral precious metal palladium-platinum-gold three-element hollow nanometer cage structure is constructed. The structure shows excellent catalytic activity on selective catalytic oxidation of D-configuration glucose molecules. The invention provides an efficient, low-cost and high-reliability biomimetic catalytic material solution for glucose detection, and promotes the upgrading of diabetes management, biosensing and food quality control technologies.

The invention discloses a preparation method of an SERS (Surface Enhanced Raman Scattering) sensing microneedle patch and application of the SERS sensing microneedle patch in detection of trace blood sugar, and belongs to the technical field of material synthesis and biosensing. According to the preparation method of the SERS sensing microneedle patch disclosed by the invention, a surface enhanced Raman spectroscopy technology and a microneedle patch technology are integrated, a designed SERS probe takes urchin-shaped gold nanoparticles as a core, and a typical core-shell structure is formed through layer-by-layer self-assembly of polydopamine and gradual re-reduction of the gold nanoparticles; the Raman scattering signal is obviously enhanced. The upper layer of the double-layer structure microneedle is hyaluronic acid wrapping glucose oxidase, and the lower layer of the double-layer structure microneedle is methacryloyl hyaluronic acid wrapping an SERS probe. After glucose of interstitial fluid is collected by the microneedle, Raman spectrum characteristic fingerprint change of the SERS probe is caused through catalysis of glucose oxidase, non-invasive, rapid and high-sensitivity blood glucose detection is achieved, and the method is a more comfortable and convenient self-monitoring method.

The invention relates to the technical field of medical detection equipment, and particularly provides a wearable sweat glucose detection system which comprises a sweat collecting and conveying unit which is provided with a sweat inlet and a sweat flow channel which are communicated with each other and is used for collecting and conveying sweat secreted by skin; the electric signal acquisition unit is arranged on the sweat flow channel, comprises a counter electrode, a working electrode and a reference electrode which are sequentially arranged along the flowing direction of sweat in the sweat flow channel, and is used for acquiring a real-time electric signal related to the glucose concentration; the working electrode comprises a porous alloy structure layer composed of platinum and nickel and a glucose oxidase layer located on the surface of the porous alloy structure layer; the signal processing unit is used for acquiring the real-time glucose concentration according to the real-time electric signal and a preset change curve of the electric signal about the glucose concentration; the system can effectively improve the sensitivity of glucose concentration detection and reduce the dosage of precious metal.

The embodiment of the invention discloses a noninvasive blood glucose detection system. The system comprises an optical transceiver assembly; the filtering unit is electrically connected with the optical transceiver assembly; the micro-processing unit is electrically connected with the filtering unit; wherein the optical transceiver assembly comprises at least two light sources, a first detector and at least two second detectors, the at least two light sources are used for emitting laser detection signals, and the first detector and the at least two second detectors are used for detecting returned laser signals; the at least two light sources are arranged around the first detector; the at least two second detectors are arranged around the light source; the light detection surface of the first detector, the light detection surfaces of the at least two second detectors and the light emitting surfaces of the at least two light sources face the same direction. According to the application, the short-optical-path optical signal and the long-optical-path optical signal are used for data analysis and processing to obtain the optical concentration difference between the deep part and the superficial part of the skin, so that the influence of melanin and the skin is reduced, and the detection precision of noninvasive blood glucose is improved.

The application discloses a kind of glucose oxidase sensors based on modified multi-walled carbon nanotube modification, it is related to glucose oxidase sensor technical field, including the following steps: (1) modified multi-walled carbon nanotube preparation;(2) glassy carbon electrode is carried out surface polishing treatment;(3) obtain modified multi-walled carbon nanotube dispersion;(4) obtain glucose oxidase liquid;(5) glucose glucose oxidase liquid impregnation electrode;(6) using Nafion solution covers electrode;The sensor obtained after the electrode is modified by introducing modified multi-walled carbon nanotube in the application, not only has higher glucose detection sensitivity, but also has excellent stability.

This invention discloses an Au / CeO2-BTC nanozyme based on strong metal-support interactions and its application in electrochemical glucose detection. The nanozyme uses a Ce-BTC metal-organic framework as a precursor, which is calcined to obtain a porous CeO2-BTC support rich in oxygen vacancies. Gold nanoparticles are then loaded onto the support via in-situ deposition. The product forms Au-O-Ce interfacial active sites and exhibits significant strong metal-support interactions, enabling electronic regulation and enhancing CeO2-support electrochemical detection. 3+ The content is increased and the charge transfer rate is accelerated. The electrode modified with this Au / CeO2-BTC nanozyme exhibits excellent catalytic performance for glucose oxidation, with a sensitivity of 41.3 μA·cm. ‑2 ·mM ‑1 The detection limit is as low as 4.75 μM, and it exhibits good reproducibility, stability, and selectivity.

The utility model discloses a fixing adhesive tape for dynamic blood glucose detection, which comprises a non-woven fabric adhesive tape, two pieces of release paper which are respectively first release paper and second release paper, and a protective film which is adhered to the non-adhesive surface of the non-woven fabric adhesive tape, and the protective film is adhered to the non-adhesive surface of the non-woven fabric adhesive tape. The first release paper and the second release paper are folded along the center lines of the first release paper and the second release paper, one half of the first release paper is attached to one half of the glued surface in the non-woven fabric adhesive tape, and one half of the second release paper is attached to the other half of the glued surface in the non-woven fabric adhesive tape; one half of the first release paper is in butt joint with one half of the second release paper and completely covers the gluing face in the non-woven fabric adhesive tape, and the other half of the first release paper is in butt joint with the other half of the second release paper in an attached mode, protrudes out of the non-woven fabric adhesive tape and is not connected with the non-woven fabric adhesive tape. The first release paper and the second release paper can be torn off more easily, the non-woven fabric adhesive tape cannot be wrinkled, the quality of the non-woven fabric adhesive tape is guaranteed, and it can be guaranteed that detection equipment is stably located on the skin of the human body.

The utility model discloses a temperature self-correcting implantable blood glucose sensor. The sensor mainly comprises a bin body, a power supply, a main board, a blood glucose processing module, a temperature correcting module, a Bluetooth receiving and transmitting module and a sensor probe module. The sensor probe module comprises a temperature detection electrode and a blood glucose detection electrode. Wherein the temperature detection electrode is an integrated electrode based on a thermistor, is attached to the surface of the blood glucose detection electrode and is used for detecting and sensing the real-time temperature of an implantation part, and the temperature change is fed back to the blood glucose detection module for correction, so that the measurement accuracy is improved. The device has the advantages of simple structure, high measurement accuracy, no environmental influence and the like, and is suitable for improving the long-term working stability of implantable blood glucose measurement equipment and the like.

The embodiment of the invention provides a manufacturing method of a test paper connector, the test paper connector and a glucometer, and relates to the field of blood glucose detection. The manufacturing method of the test paper connector comprises the following steps: adjusting the height h of the pin of the test paper seat plug-in device to be lower than the height H of the positioning column; mounting a test paper holder plug-in device and a bottom surface component on the PCB; performing reflow soldering on the test paper holder plug-in device and the bottom surface component; and mounting a top surface component on the top surface of the PCB. According to the manufacturing method disclosed by the embodiment of the invention, the sizes of the positioning columns and the pins of the test paper seat plug-in device are adjusted, the pins are prevented from scraping a steel mesh, the test paper seat plug-in device is mounted in the jacks when the components on the bottom surface of the PCB are mounted, and then reflow soldering is performed together, so that the test paper seat plug-in device does not need to be manually post-welded, the operation step of manual welding is omitted, and the production efficiency is improved. One mounting operation procedure is reduced, the production efficiency can be improved, and the production cost is reduced. The embodiment of the invention also provides a test paper connector and a glucometer.

The invention discloses a self-adaptive indwelling type blood glucose prober, and relates to the technical field of blood glucose detection, the self-adaptive indwelling type blood glucose prober comprises a lower frame, the top of the lower frame is movably provided with an upper frame through a hinge, the top of the upper frame is provided with a controller component, and the top of the upper frame is provided with a blood glucose meter component in a penetrating manner; a first lifting plate component is installed at the output end of the first electric telescopic rod component, a limiting mechanism is arranged on the inner side of the first lifting plate component, a plurality of second electric telescopic rod components are symmetrically installed on the back face of the upper frame, and limiting plate components are installed at the output ends of the second electric telescopic rod components. An indwelling needle is inserted into a blood vessel at the top of a hand, a cotton ball is pressed on the indwelling needle through a medical easily-torn adhesive tape, the cotton ball and the indwelling needle are fixed through the easily-torn adhesive tape, and the bottoms of the hands of patients with different thicknesses can be extruded and fixed by moving the first lifting plate component and the telescopic plate upwards; the side faces of the patients with different widths can be extruded and fixed by moving the limiting plate component forwards.