34 results about "Normal blood glucose" patented technology

The invention provides nutritional supplements for an oral or enteral administration to humans, whether in satisfactory health, or having a medical condition. These supplements can provide humans with a complete, balanced nutrition in a bioavailable form, either as a food supplement or as a meal replacement, and preferably includes one or more slow-digesting carbohydrates that renders them effective in maintaining blood glucose levels at, or returning abnormal blood glucose levels to, normal blood glucose levels. Nutritional supplements within the invention can be employed with humans that are diabetic, borderline diabetic, pregnant and / or lactating, geriatric humans and humans that have, are at risk for, or develop other glucose intolerance or cardiovascular disease.

Embodiments of the present invention include the in vivo use of a family of heterocyclic compounds containing a quaternary ammonium group as exemplified by the thioxanthone and thioxanthene compounds [3-(3,4-dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl]trimethylammonium chloride, or CCcompound1, N,N,-diethyl-N-methyl-2-[9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide, or CCcompound3, and N,N,N-trimethyl-3-(9H-thioxanthen-9-ylidene)-propane-1-aminium iodide, or CCcompound19 to reduce higher than normal blood glucose level within or close to the normal range in subjects with insulin resistance, hyperglycemia, and diabetes thereby also reducing or preventing associated diseases, complications, and pathological states.

The invention provides a portable multifunctional intelligent insulin pump which has high degree of intensification and is based on the modern electronic technology, and a control module thereof, and the intelligent insulin pump is composed of an intelligent insulin pump body, a blood glucose detection sensor which is directly connected therewith and an infusion actuator. The change of the blood glucose is tracked by dynamic monitoring of the blood glucose level of a user, thus infusing the insulin for the treatment of diabetes. The insulin pump body is connected with a mobile phone by a communication protocol, and the user can control the infusion amount by the mobile phone. The errors of the monitoring of the blood glucose are calculated according to the characteristics of the self blood glucose and the basic amount of the normal blood glucose of the user, thus establishing the control model of the infusion pump. When the blood glucose content exceeds the allowable range, the controller emits a command, a drive mechanism allows the insulin in a liquid storage tank to pass a pipeline, and the insulin is infused to the body of the user by utilizing the infusion actuator. The invention is the complete and integrated novel insulin treatment instrument which has the effects of waterproof, corrosion resistance, vibration resistance and low power consumption and can not affect the normal life and be worked basically and normally.

The invention discloses an immortalized porcine pancreatic stem cell line and construction and differentiation methods thereof. In the immortalized porcine pancreatic stem cell line, porcine pancreatic stem cells are taken as host cells and are transfected with a pCI-neo-hTERT eukaryotic expression vector, and the human telomerase reverse transcriptase screened by G418 is expressed and has a transformant with multi-directional differentiation potentiality. The cell line also has higher activity after transferring for over 50 generations in vitro, keeps split proliferation, does not generate aging or apoptosis, and is an immortalized cell line. The cell line can be differentiated to form functional islet cell mass after induction, can reduce the blood glucose concentration after being transplanted into a mouse model suffering from diabetes and can maintain a normal blood glucose level within two weeks.

Disclosed are a composition for preventing or treating diabetes, diabesity or diabetic complications, containing an oxyntomodulin analog as an active ingredient and a method for treating diabetes, diabesity or diabetic complications, including administering a pharmaceutically effective amount of an oxyntomodulin analog to a subject. The oxyntomodulin analog shows a greater activity to activate a GLP-1 receptor and a glucagon receptor, than native oxyntomodulin. The oxyntomodulin analog induces an expansion of beta-cells and increases insulin secretion, thereby reducing blood glucose levels that were increased due to a high-calorie and high-fat diet. The oxyntomodulin analog induces decreases in a body weight and appetite to improve insulin sensitivity and is useful in maintaining normal blood glucose levels.

The invention discloses a method for establishing a model for early prediction of gestational diabetes mellitus, comprising the following steps: 1, clinically retrospectively collecting a plurality ofpregnant women with normal blood glucose during pregnancy and gestational diabetes mellitus, taking the pregnant women as total collection cases, and collecting information data of each case; 2, randomly extracting a plurality of cases from the total collection cases in the step 1 to serve as a training set; compiling a LightGBM model in the form of 'yes-no' by using a Python language and spyderor jupyter notebook software; setting model parameters, then importing information data of each case of the training set and a result of finally judging whether the patient suffers from gestational diabetes mellitus or not, and constructing a LightGBM prediction model; and 3, inputting the information data of the pregnant woman to be predicted into the lightBGM prediction model constructed in thestep 2 to obtain a prediction risk value of the gestational diabetes mellitus risk in the future, and determining whether the pregnant woman will be sick or not according to the prediction risk value.The method has the advantages of simple and convenient implementation, high result accuracy and the like.

The invention provides a processing method of fresh scent stevia tea. The method comprises the processes of harvesting, sorting, spreading, rocking, fumigating, carrying out fixation, slightly rolling, spraying juice, baking, rapidly cooling, and the like; the processing method is simple in technology, low in requirements for equipment and high in operability, and can be popularized in the actual production. The fresh scent stevia tea prepared by the processing method does not contain a preservative, a stabilizer, a thickening agent, pigment and the like, thus being a pure natural plant tea; after being brewed for drinking for a long time, the fresh scent stevia tea has the health care effects of reducing cholesterol, preventing and treating diabetes mellitus, enhancing the immunity of a human body, losing weight and beautifying skin, nourishing yin and generating body fluid, helping digestion, harmonizing spleen and stomach as well as clearing away heat and toxic materials. Furthermore, after being brewed, the fresh scent stevia tea has the outstanding characteristics of being low in calories, enabling carbohydrates not to be absorbed by the human body and not influencing the normal blood glucose level, thus being especially suitable for obesity patients, hypertensives and diabetic patients to drink everyday; furthermore, the fresh scent stevia tea has remarkable health care effects and medicinal value.

The invention belongs to the technical field of blood glucose lowering drugs, and provides creeping liriope-figwort-milkvetch root soft capsules and a preparation method thereof, wherein a purpose of the present invention is to solve the problem of side effects of long-term administration high blood glucose patients. The creeping liriope-figwort-milkvetch root soft capsules are prepared from creeping liriope, figwort, common anemarrhena, common yam rhizome, milkvetch root, swordlike atractylodes rhizome, rehmannia dride rhizome, medlar, lobed kudzuvine root, salvia miltiorrhiza, cortex moutan, sea buckthorn seed oil, beeswax, gelatin, glycerol and water according to a certain ratio. According to the present invention, based on the traditional Chinese medicine theory whole view, both symptoms and root causes are treated; diabetes involving the upper warmer, diabetes involving the middle warmer and diabetes involving the lower warmer are concurrently treated; the disease can be prevented; the whole human body function can be regulated; various herbs are subjected to compatibility to provide effects of reinforcement, no greasiness, rigid-flexible supplement, qi supplementing and yin nourishing so as to treat the root causes, and provide effects of heat clearing and collateral dredging so as to treat the symptoms and prevent the change; and pharmacological toxicology clinical data prove that the creeping liriope-figwort-milkvetch root soft capsules have characteristics of no toxic-side effect, no influence on human body normal blood glucose, high blood glucose lowering effect, blood fat lowering, body health maintaining, endocrine improvement and regulation, and are the ideal blood glucose lowering product.

The invention provides a blood glucose control method and system, wearable equipment and a storage medium. The method comprises the following steps: determining the current control link level of a diabetic patient at the current moment according to the basic parameters of the diabetic patient at the current moment; calculating an association probability value of the control link level and the blood glucose test value through a Bayesian algorithm; and according to the association probability value, adjusting and updating the control link level to make the blood glucose test value obtained by re-testing after adjustment close to the corresponding normal blood glucose range value. According to the invention, the adjustment scheme including the blood glucose control link level is automaticallyupdated, so that the diabetic patient performs blood glucose control according to the adjustment scheme, the self-management compliance of the diabetic patient is improved, and the physical fitness of the diabetic patient is improved or enhanced.

The invention discloses a special medicine box for diabetic patients. The special medicine box for diabetic patients comprises a base, an insulin storage unit and an oral medicine storage unit. The insulin storage unit and the oral medicine storage unit are arranged on the upper part of the base and are arranged in parallel, and the insulin storage unit comprises a box body, a box cover, a first storage tank, a second storage tank and a semiconductor refrigerating sheet. The special medicine box for diabetic patients can store an insulin pen, an insulin cartridge and an oral medicine simultaneously, so that the diabetic patients take two means of orally taking medicines and injecting insulin to reduce blood glucose so as to recover blood glucose level of the patients. The special medicinebox for diabetic patients also has a refrigerating function, and a condition that insulin in the insulin pen and the insulin cartridge goes bad as the temperature is high can be prevented, so that themedication safety of the patients is guaranteed. The special medicine box for diabetic patients has a function of reminding a doctor to adjust a medication scheme timely so as to make sure that the normal blood glucose value of the patients is restored.

An embodiment of the invention may include a method, computer program product and computer system for glucose management. The method, computer program product and computer system may include a computing device which may collect application data associated with a user and receive data from the user. The computing device may create a user profile from the received data and analyze the collected application data and the user profile to identify one or more user activities and associated blood glucose levels for the user for the one or more activities. The computing device may analyze the application data to determine a current status of the user or a future planned activity of the user is associated with an abnormal blood glucose level. The computing device may generate a recommendation for maintaining a normal blood glucose level for display to the user.

The present invention relates to a novel hypoglycemic / anti-hyperglycemic protein named ADMc1 purified from the seeds of Momordica charantia for control of hyperglycemia. The process for the purification of novel hypoglycemic / anti-hyperglycemic protein named ADMc1 is also disclosed. The invention also relates to process for preparation and purification of the recombinant novel hypoglycemic / anti-hyperglycemic protein of Momordica charantia, named rADMc1. Both ADMc1 and rADMc1 are highly effective and need to be administered only once a day to maintain normal blood glucose levels. The procedure involves purification of a novel hypoglycemic / anti-hyperglycemic protein of M. charantia, construction of cDNA library from M. charantia seeds, screening of cDNA library using oligonucleotide probe designed on the basis of amino acid sequence of the tryptic fragment of the protein, cloning of the cDNA in a eukaryotic expression system, expression and purification of the recombinant protein.

The invention discloses a processing method for cucumber juice with suspended fruit pulp granules. Cucumbers are used as main materials. The original fresh and delicious taste of the made cucumber juice is kept; the densities of different parts of cucumbers are different, the cucumber granules obtained through cutting have different densities and are suspended in sugar water, no suspension agent is adopted, the problems that the taste and dietary fiber of cucumber juice cannot be obtained at the same time in the prior art, and a suspension agent is added when fruit pulp granules are suspended are solved. Dietary fiber intake is improved, the nutritional ingredients of cucumbers are not lost, the high-quality taste is kept, the taste is improved, the weight losing effect is achieved, the digestion function and the heart function are enhanced, the level of harmful cholesterol is lowered, blood vessels can be softened, and angiosclerosis is delayed; the blood pressure is lowered to be kept normal, the normal blood glucose level is maintained, cancer cells are prevented from being produced, the skin is whitened, and the skin is kept smooth and moist; heavy metal in the body is eliminated, the tension fatigue is relieved, people can fall asleep easily, and practicability is high.

The invention belongs to the technical field of blood glucose lowering drugs, and provides creeping liriope-figwort-milkvetch root soft capsules and a preparation method thereof, wherein a purpose of the present invention is to solve the problem of side effects of long-term administration high blood glucose patients. The creeping liriope-figwort-milkvetch root soft capsules are prepared from creeping liriope, figwort, common anemarrhena, common yam rhizome, milkvetch root, swordlike atractylodes rhizome, rehmannia dride rhizome, medlar, lobed kudzuvine root, salvia miltiorrhiza, cortex moutan, sea buckthorn seed oil, beeswax, gelatin, glycerol and water according to a certain ratio. According to the present invention, based on the traditional Chinese medicine theory whole view, both symptoms and root causes are treated; diabetes involving the upper warmer, diabetes involving the middle warmer and diabetes involving the lower warmer are concurrently treated; the disease can be prevented; the whole human body function can be regulated; various herbs are subjected to compatibility to provide effects of reinforcement, no greasiness, rigid-flexible supplement, qi supplementing and yin nourishing so as to treat the root causes, and provide effects of heat clearing and collateral dredging so as to treat the symptoms and prevent the change; and pharmacological toxicology clinical data prove that the creeping liriope-figwort-milkvetch root soft capsules have characteristics of no toxic-side effect, no influence on human body normal blood glucose, high blood glucose lowering effect, blood fat lowering, body health maintaining, endocrine improvement and regulation, and are the ideal blood glucose lowering product.

The invention relates to a blood glucose detection method based on slit waveguide, wherein an annular slit region between a straight waveguide and a microring waveguide is a detection channel for flow of a blood sample requiring detection, and a refractive index of the straight waveguide material is higher than a refractive index of the blood sample. The method comprises that: 1) a blood sample with normal blood glucose is adopted to carry out a calibration test, and passes through the annular slit region, and a resonance wavelength of the microring waveguide is a calibration wavelength after light is introduced into the high refractive index straight waveguide; and 2) a blood sample requiring detection passes through the annular slit region, the current resonance wavelength of the microring waveguide is detected after light is introduced into the high refractive index straight waveguide, it is determined that the blood glucose concentration of the blood sample requiring detection is normal if the current resonance wavelength is equal to the calibration wavelength, and it is determined that the blood glucose concentration of the blood sample requiring detection is abnormal if the current resonance wavelength is not equal to the calibration wavelength. According to the present invention, high detection efficiency and rapid response are met, the structure is simplified, the size is reduced, and the cost is reduced.

The invention discloses an immortalized porcine pancreatic stem cell line and construction and differentiation methods thereof. In the immortalized porcine pancreatic stem cell line, porcine pancreatic stem cells are taken as host cells and are transfected with a pCI-neo-hTERT eukaryotic expression vector, and the human telomerase reverse transcriptase screened by G418 is expressed and has a transformant with multi-directional differentiation potentiality. The cell line also has higher activity after transferring for over 50 generations in vitro, keeps split proliferation, does not generate aging or apoptosis, and is an immortalized cell line. The cell line can be differentiated to form functional islet cell mass after induction, can reduce the blood glucose concentration after being transplanted into a mouse model suffering from diabetes and can maintain a normal blood glucose level within two weeks.

The invention discloses a cucumber drink containing suspended pulp particles and prepared from cucumber serving as a main material. The original refreshing taste of cucumber juice is kept, diced cucumber has different densities and is suspended in sugar water due to different densities of different parts of the cucumber, no suspending agent is used, the problems that cucumber juice in prior art doesn't have good taste or doesn't contain much dietary fiber and a suspending agent is added when pulp particles are suspended are solved, ingestion of the dietary fiber is realized, nutritional ingredients of the cucumber are not lost, high-quality taste is kept, the flavor is improved, and the cucumber drink has the efficacy of reducing weight and improves the digestion function and the heart function; the level of harmful cholesterol is reduced; blood vessels can be softened, and angiosclerosis is delayed; the blood pressure is reduced (the normal blood pressure is maintained); the normal blood glucose level is maintained; generation of cancer cells is prevented; skin is whitened, and smoothness and moisturizing of the skin are kept; heavy metals in a body are eliminated; tonus fatigue feeling is relieved, and the cucumber drink can promote people to fall asleep easily and has high practicability.

The invention discloses a tea drink with effects of reducing blood glucose and proteinuria for sub-health population. The active ingredients of the tea drink are prepared from the following raw medicinal materials: corn stigma, hemp leaves, lophatherum gracile, lycium barbarum and liquorice. The tea drink disclosed by the invention has a certain effect of reducing blood glucose and proteinuria, but the reduction scale is not too large. Therefore, the tea drink is particularly applicable to the sub-health population having sustained fasting blood-glucose equivalent to a normal blood glucose value or slightly higher than the normal blood glucose value, and the blood glucose index of the sub-health population can be reduced from a high critical point to a normal range.

The invention relates to formulas of main materials, auxiliary materials and seasonings of a staple food grain prebiotic culture medium which is also called Tianfu TNB, edible fungi and fermentation equipment. The staple food grains comprise rice, corn and soybeans. The edible fungi are family-borne edible microbial flora (FEMF) and improved auxiliary bacteria thereof, the flora structure, the strain of the improved FEMF flora and the structure and proportion of the auxiliary flora are clarified, and the microbial agent presents a sour and sweet taste after being fermented. The fermentation technology has 1-5 grades, and the product technology comprises liquid state and solid state. In order to facilitate fermentation, simple fermentation equipment capable of rotating by 360 degrees is designed and manufactured. After eating the product for 17 days, young and middle-aged people have stable and normal blood glucose; a 83-year-old diabetic patient who is always dizzy and has cardiac pain is basically cured and the immunocompetence is improved after 3 months; and for a patient with long-term family inherited long-term type II diabetes mellitus, who is injected with insulin, takes western medicines and has blood glucose of 14.2 during empty stomach, blood glucose is normal after 28 days of adjuvant therapy, and gastritis and urinary system diseases are both improved.

The invention provides a blood glucose related index information processing method and device and electronic equipment, and the method comprises the steps: obtaining the blood glucose related index information of a user, and determining an index parameter corresponding to the blood glucose related index information; processing index parameters corresponding to the blood glucose related index information by utilizing a support vector machine (SVM) to obtain a deviation degree value of the blood glucose related index information and normal blood glucose related index information corresponding tothe blood glucose related index information; and when the deviation degree value of the blood glucose related index information relative to the normal blood glucose related index information corresponding to the blood glucose related index information is greater than a deviation degree threshold value of the normal blood glucose related index information corresponding to the blood glucose relatedindex information, suggesting a life style for the user. By means of the blood glucose related index information processing method and device and the electronic equipment, the health condition of theuser can be evaluated, life style suggestions can be given, and operation is easy and convenient.

The invention discloses a preparation method of a sweet orange fruit vinegar. The preparation method comprises the following steps of S1, sorting the sweet orange fruit, removing the rooted and deteriorated sweet orange fruit, and cleaning the high-quality fruit for 5 to 10min by a cleaning machine; S2, sending the cleaned fruit into a crushing machine, crushing, pressing to obtain juice, filtering, immediately heating the pressed fruit juice, and deactivating enzyme in a heat way; S3, adding rocky sugar and yeast into the juice in step 2; S4, adding acetic acid bacteria into the juice in step3, fermenting by acetic acid, and aging; S5, filtering the juice in step 4 by a filter cloth with size of 120 meshes; S6, adding honey and sucrose into the juice in step 5 to adjust, and uniformly stirring; S7, filling the juice in step 6, heating and sterilizing for 15 to 20min at the temperature of 75 to 90 DEG C, and cooling, so as to obtain the sweet orange fruit vinegar. The sweet orange fruit vinegar has the advantages that the utilization rate of sweet orange fruit is improved, the absorption utilization rate of a human body is improved, the digestion function is enhanced, the heart iswell protected, the normal blood glucose level is maintained, and the mouth feel is better when the sweet orange fruit vinegar is drunk.

Disclosed are a composition for preventing or treating diabetes, disbesity or diabetic complications, containing an oxyntomodulin analog as an active ingredient and a method for treating diabetes, diabesity or diabetic complications, including administering a pharmaceutically effective amount of an oxyntomodulin analog to a subject. The oxyntomodulin analog shows a greater activity to activate a GLP-1 receptor and a glucagon receptor, than native oxyntomodulin. The oxyntomodulin analog induces an expansion of beta-cells and increases insulin secretion, thereby reducing blood glucose levels that were increased due to a high-calorie and high-fat diet. The oxyntomodulin analog induces decreases in a body weight and appetite to improve insulin sensitivity and is useful in maintaining normal blood glucose levels.

The present invention relates to a novel hypoglycemic / anti-hyperglycemic protein named ADMc1 purified from the seeds of Momordica charantia for control of hyperglycemia. The process for the purification of novel hypoglycemic / anti-hyperglycemic protein named ADMc1 is also disclosed. The invention also relates to process for preparation and purification of the recombinant novel hypoglycemic / anti-hyperglycemic protein of Momordica charantia, named rADMc1. Both ADMc1 and rADMc1 are highly effective and need to be administered only once a day to maintain normal blood glucose levels. The procedure involves purification of a novel hypoglycemic / anti-hyperglycemic protein of M. charantia, construction of cDNA library from M. charantia seeds, screening of cDNA library using oligonucleotide probe designed on the basis of amino acid sequence of the tryptic fragment of the protein, cloning of the cDNA in a eukaryotic expression system, expression and purification of the recombinant protein.

The invention belongs to the technical field of biomedical engineering, and discloses a blood glucose equipment control method, system and device, a storage medium and a program. According to the method, intelligent real-time administration hyperglycemia control equipment is connected; a normal blood glucose concentration range is set to be 3.1 mmol / L to 6.9 mmol / L; a client constantly receives equipment detection data and compares the equipment detection data with a standard blood glucose concentration stored in the client for reference; if the blood glucose concentration exceeds the blood glucose concentration range, a command is sent to control the release of a hypoglycemic agent, and otherwise, no response is made; if the equipment releases the hypoglycemic agent to continuously adjustthe blood sugar, related detection data are received again, if the blood sugar value is normal, a command is sent out, and the intelligent real-time administration hyperglycemia control equipment controls to stop the release of the hypoglycemic agent. According to the invention, through real-time on-line monitoring, the dosage can be intelligently, scientifically and reasonably controlled, so that the dosage of a patient can be controlled at a reasonable level according to individual differences; and timely on-line feedback is realized, so that tedious manual administration is avoided, and the purpose of effectively controlling diabetes mellitus is achieved.

The invention discloses a composition with effects of decreasing blood sugar and protecting liver. The composition at least comprises the following components in parts by weight: 20-80 parts of rehmannia glutinosa oligosaccharides and 20-80 parts of manno-oligosaccharides. According to the composition disclosed by the invention, the rehmannia glutinosa oligosaccharides and manno-oligosaccharides are simultaneously used, and due to the anatomical structures and functions of the intestinal tract and liver as well as intestinal microecological balance, the gut-liver axes are mutually influenced under multiple mechanisms so as to form strong balanced synergistic effects. Therefore, the composition has the advantages that the effects of decreasing blood sugar, maintaining the normal blood glucose level and protecting the liver are obviously improved when being compared with those of any of the rehmannia glutinosa oligosaccharides or manno-oligosaccharides.

The present invention belongs to the technical field of biomedicine, and particularly relates to a lisinopril compound preparation and a preparation method thereof. In the prior art, the blood pressure lowering effect is not good in the application of the existing lisinopril tablet in the diabetes patient with hypertension. Based on the problem in the prior art, the invention provides a lisinopril compound preparation, which comprises, 10-20 parts of lisinopril, 10-20 parts of gliquidone, and 100-500 parts of an auxiliary material. The preparation method comprises: preparing a soft material A from lisinopril and materials, preparing a soft material B from gliquidone and an auxiliary material, taking the same doses of the soft material A and the soft material B, uniformly tableting to form a tablet, placing into a lactose solution with a concentration of 80-90%, soaking for 3-5 h, and drying to obtain the lisinopril compound preparation. According to the present invention, the prepared lisinopril compound preparation can lower the blood glucose concentration, and can provide the good blood pressure lowering effect in the case of the normal blood glucose, and the preparation method is simple, and is suitable for promotion use.

The invention discloses a composition with effects of decreasing blood sugar and protecting liver. The composition at least comprises the following components in parts by weight: 20-80 parts of rehmannia glutinosa oligosaccharides and 20-80 parts of manno-oligosaccharides. According to the composition disclosed by the invention, the rehmannia glutinosa oligosaccharides and manno-oligosaccharides are simultaneously used, and due to the anatomical structures and functions of the intestinal tract and liver as well as intestinal microecological balance, the gut-liver axes are mutually influenced under multiple mechanisms so as to form strong balanced synergistic effects. Therefore, the composition has the advantages that the effects of decreasing blood sugar, maintaining the normal blood glucose level and protecting the liver are obviously improved when being compared with those of any of the rehmannia glutinosa oligosaccharides or manno-oligosaccharides.

The invention relates to an intelligent responsive sustained-release microsphere and a preparation method thereof. A novel microsphere preparation is characterized in that the microsphere contains a microsphere with small particle size, the outer microsphere takes polylactic acid-glycolic acid copolymer (PLGA) as a carrier material, the microsphere with small particle size takes polyketal or derivatives thereof as a skeleton, a model medicine is embedded in the skeleton, and a glucose oxidase trigger and a catalase trigger are dispersed on the outer part of the microsphere with small particlesize. According to the preparation method, an intelligent responsive novel microsphere is prepared, the serious situation of sudden release of an ordinary microsphere preparation for treating diabetesis solved, especially hypoglycemia caused by continuous medicine release under normal blood glucose concentration, and important clinical application value is achieved.